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Barrett and diagnostic

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https://www.readbyqxmd.com/read/29752721/can-endoscopic-resection-for-barrett-s-dysplasia-and-early-cancer-be-curative
#1
REVIEW
Shai Friedland, George Triadafilopoulos
Effective endoscopic treatments for dysplasia and early (intramucosal) cancer, together with expanded and rigorous screening programs to detect Barrett's esophagus, could help reverse the increase in the incidence of esophageal cancer and reduce esophageal cancer-related mortality. In this review, we discuss the long-term outcomes for mucosal resection for dysplasia and early cancer and compares them to esophagectomy as the standard of care choice. Eendoscopic resection for Barrett's dysplasia and early cancer can be curative but only when the lesion can be classified as: Paris type I (polypoid); Paris IIa (slightly elevated); Paris IIb (flat); Paris IIc (slightly depressed); histological grades G1 and G2; high-grade dysplasia...
May 11, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29752303/typical-features-of-parkinson-disease-and-diagnostic-challenges-with-microdeletion-22q11-2
#2
Erik Boot, Nancy J Butcher, Sean Udow, Connie Marras, Kin Y Mok, Satoshi Kaneko, Matthew J Barrett, Paolo Prontera, Brian D Berman, Mario Masellis, Boris Dufournet, Karine Nguyen, Perrine Charles, Eugénie Mutez, Teodor Danaila, Aurélia Jacquette, Olivier Colin, Sophie Drapier, Michel Borg, Ania M Fiksinski, Elfi Vergaelen, Ann Swillen, Annick Vogels, Annika Plate, Claudia Perandones, Thomas Gasser, Kristien Clerinx, Frédéric Bourdain, Kelly Mills, Nigel M Williams, Nicholas W Wood, Jan Booij, Anthony E Lang, Anne S Bassett
OBJECTIVE: To delineate the natural history, diagnosis, and treatment response of Parkinson disease (PD) in individuals with 22q11.2 deletion syndrome (22q11.2DS), and to determine if these patients differ from those with idiopathic PD. METHODS: In this international observational study, we characterized the clinical and neuroimaging features of 45 individuals with 22q11.2DS and PD (mean follow-up 7.5 ± 4.1 years). RESULTS: 22q11.2DS PD had a typical male excess (32 male, 71...
May 11, 2018: Neurology
https://www.readbyqxmd.com/read/29707844/additional-palmaroproximal-palmarodistal-oblique-radiographic-projections-improve-accuracy-of-detection-and-characterization-of-equine-flexor-cortical-lysis
#3
Sherry A Johnson, Myra F Barrett, David D Frisbie
Radiographic flexor cortical lysis indicates advanced degenerative change and its earlier recognition may improve case outcome. Aims of this prospective, diagnostic accuracy study were to determine effects of radiographic beam angle and observer on accuracy of lesion detection. The sample included 36 limbs from 31 horses. Palmaroproximal-palmarodistal oblique (skyline) radiographs were acquired at standard (n = 38) and more shallow (alternate) angles (n = 58). Images were independently reviewed by four experience levels of five observers each (n = 20) for the presence and severity of flexor cortical lysis...
April 29, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29699001/national-implementation-of-multi-parametric-mri-for-prostate-cancer-detection-recommendations-from-a-uk-consensus-meeting
#4
REVIEW
Mrishta Brizmohun Appayya, Jim Adshead, Hashim U Ahmed, Clare Allen, Alan Bainbridge, Tristan Barrett, Francesco Giganti, John Graham, Phil Haslam, Edward W Johnston, Christof Kastner, Alexander P S Kirkham, Alexandra Lipton, Alan McNeill, Larissa Moniz, Caroline M Moore, Ghulam Nabi, Anwar R Padhani, Chris Parker, Amit Patel, Jacqueline Pursey, Jonathan Richenberg, John Staffurth, Jan van der Meulen, Darren Walls, Shonit Punwani
OBJECTIVES: To identify areas of agreement and disagreement in the implementation of multi-parametric MRI (mpMRI) of the prostate in the diagnostic pathway. MATERIALS AND METHODS: Fifteen UK experts in prostate mpMRI and/or prostate cancer management across the UK (involving 9 NHS centres to provide for geographical spread) participated in a consensus meeting following the UCLA-RAND Appropriateness Method, and were moderated by an independent chair. The experts considered 354 items pertaining to who can request an mpMRI, prostate mpMRI protocol, reporting guidelines, training, quality assurance (QA) and patient management based on mpMRI levels of suspicion for cancer...
April 26, 2018: BJU International
https://www.readbyqxmd.com/read/29685538/role-of-propeller-dwi-of-the-prostate-in-reducing-distortion-and-artefact-from-total-hip-replacement-metalwork
#5
Marcin Czarniecki, Iztok Caglic, James T Grist, Andrew B Gill, Kamil Lorenc, Rhys A Slough, Andrew N Priest, Tristan Barrett
OBJECTIVE: To compare image quality, artefact, and distortion in standard echo-planar imaging (EPI) with periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) for prostate magnetic resonance imaging (MRI) diffusion-weighted imaging (DWI) in patients with previous total hip replacement (THR). METHODS: 21 male subjects with a clinical suspicion for, or known prostate cancer and previous THR were scanned at 1.5 T using a phased-array body coil...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29684625/nanomechanics-and-ultrastructure-of-the-internal-mammary-artery-adventitia-in-patients-with-low-and-high-pulse-wave-velocity
#6
Zhuo Chang, Paolo Paoletti, Steve D Barrett, Ya Hua Chim, Eva Caamaño-Gutiérrez, Maria Lyck Hansen, Hans Christian Beck, Lars Melholt Rasmussen, Riaz Akhtar
The collagen-rich adventitia is the outermost arterial layer and plays an important biomechanical and physiological role in normal vessel function. While there has been a lot of effort to understand the role of the medial layer on arterial biomechanics, the adventitia has received less attention. In this study, we hypothesized that different ultrastructural and nanomechanical properties would be exhibited in the adventitia of the internal mammary artery (IMA) in patients with a low degree of arterial stiffening as compared to those with a high degree of arterial stiffening...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29678750/specific-igg-4-antibodies-to-cow-s-milk-proteins-in-pediatric-eosinophilic-esophagitis
#7
Alexander J Schuyler, Jeffrey M Wilson, Anubha Tripathi, Scott P Commins, Princess U Ogbogu, Patrice G Kruzsewski, Barrett H Barnes, Emily C McGowan, Lisa J Workman, Jonas Lidholm, Sheryl L Rifas-Shiman, Emily Oken, Diane R Gold, Thomas A E Platts-Mills, Elizabeth A Erwin
BACKGROUND: Allergen-specific IgG4 antibodies are often associated with tolerance, but specific IgG4 antibodies (sIgG4 ) to causally relevant foods have recently been reported in adult eosinophilic esophagitis (EoE). Prevalence and levels of food-sIgG4 are not well established in the general pediatric population. OBJECTIVE: We sought to investigate serum food-sIgG4 with component diagnostics in children with EoE and children from an unselected birth cohort and to explore the effects of sex, age and milk consumption on sIgG4 levels METHODS: Sera from 71 cases of pediatric EoE and 210 early-adolescent children from an unselected birth cohort (Project Viva) were assayed for sIgG4 and specific IgE (sIgE) to major cow's milk (CM) proteins (α-lactalbumin, β-lactoglobulin, caseins) and to wheat, soy, egg, and peanut proteins...
April 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29671159/clinical-guidelines-update-on-the-diagnosis-and-management-of-barrett-s-esophagus
#8
REVIEW
Michelle Clermont, Gary W Falk
Barrett's esophagus is a condition in which metaplastic columnar epithelium replaces stratified squamous epithelium in the distal esophagus. This condition occurs due to chronic gastroesophageal reflux disease and is a risk factor for the development of esophageal adenocarcinoma. Multiple clinical guidelines have been published around the world in recent years to assist gastroenterologists in the management of these patients and have evolved as new data have become available. While some information such as surveillance technique has not drastically changed, there has been an evolution over the years in diagnostic criteria, screening and endoscopic therapy with a variety of subtle differences among the different guidelines...
April 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29652490/immunoassay-multiplexing-on-a-cmos-photodiode-array
#9
Bence Nagy, Mohammed Al-Rawhani, Boon Chong Cheah, Michael P Barrett, David R S Cumming
Scalable immunoassay multiplexing offers a route to creating rapid point-of-care (POC) diagnostics. We present a method for multiplexing immunoassays on the surface of a complementary metal-oxide-semiconductor (CMOS) sensor array integrated circuit (IC) without the use of physical separators such as wells or channels. Major advantages of using a CMOS sensor array include low mass-manufacturing costs, the possibility to multiplex multiple assays on a single IC and improved signal when averaging multiple sensors, along with providing a platform where wash steps can be incor-porated to maximize selectivity and sensitivity compared to paper based lateral flow immunoassay...
April 13, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29651981/lamotrigine-for-people-with-borderline-personality-disorder-a-rct
#10
Mike J Crawford, Rahil Sanatinia, Barbara Barrett, Gillian Cunningham, Oliver Dale, Poushali Ganguli, Geoff Lawrence-Smith, Verity C Leeson, Fenella Lemonsky, Georgia Lykomitrou-Matthews, Alan Montgomery, Richard Morriss, Jasna Munjiza, Carol Paton, Iwona Skorodzien, Vineet Singh, Wei Tan, Peter Tyrer, Joseph G Reilly
BACKGROUND: No drug treatments are currently licensed for the treatment of borderline personality disorder (BPD). Despite this, people with this condition are frequently prescribed psychotropic medications and often with considerable polypharmacy. Preliminary studies have indicated that mood stabilisers may be of benefit to people with BPD. OBJECTIVE: To examine the clinical effectiveness and cost-effectiveness of lamotrigine for people with BPD. DESIGN: A two-arm, double-blind, placebo-controlled individually randomised trial of lamotrigine versus placebo...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29651763/computer-aided-diagnosis-prior-to-conventional-interpretation-of-prostate-mpmri-an-international-multi-reader-study
#11
Matthew D Greer, Nathan Lay, Joanna H Shih, Tristan Barrett, Leonardo Kayat Bittencourt, Samuel Borofsky, Ismail Kabakus, Yan Mee Law, Jamie Marko, Haytham Shebel, Francesca V Mertan, Maria J Merino, Bradford J Wood, Peter A Pinto, Ronald M Summers, Peter L Choyke, Baris Turkbey
OBJECTIVES: To evaluate if computer-aided diagnosis (CAD) prior to prostate multi-parametric MRI (mpMRI) can improve sensitivity and agreement between radiologists. METHODS: Nine radiologists (three each high, intermediate, low experience) from eight institutions participated. A total of 163 patients with 3-T mpMRI from 4/2012 to 6/2015 were included: 110 cancer patients with prostatectomy after mpMRI, 53 patients with no lesions on mpMRI and negative TRUS-guided biopsy...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29650469/expanding-the-traditional-role-of-optometry-current-practice-patterns-and-attitudes-to-enhanced-glaucoma-services-in-ireland
#12
Catriona Barrett, James Loughman
PURPOSE: To investigate current diagnostic equipment availability and usage for glaucoma case-finding within community optometric practice, and to explore optometrists' attitudes towards an enhanced scope of clinical practice. METHODS: An anonymous survey was developed, validated, and distributed to all optometrists in Ireland. RESULTS: 199 optometrists (27% of registrants) responded to the survey. 87% had access to the traditional triad of tests necessary to conduct adequate glaucoma case finding...
April 9, 2018: Journal of Optometry
https://www.readbyqxmd.com/read/29621901/the-clinical-effectiveness-and-cost-effectiveness-of-lamotrigine-in-borderline-personality-disorder-a-randomized-placebo-controlled-trial
#13
Mike J Crawford, Rahil Sanatinia, Barbara Barrett, Gillian Cunningham, Oliver Dale, Poushali Ganguli, Geoff Lawrence-Smith, Verity Leeson, Fenella Lemonsky, Georgia Lykomitrou, Alan A Montgomery, Richard Morriss, Jasna Munjiza, Carol Paton, Iwona Skorodzien, Vineet Singh, Wei Tan, Peter Tyrer, Joseph G Reilly
OBJECTIVE: The authors examined whether lamotrigine is a clinically effective and cost-effective treatment for people with borderline personality disorder. METHOD: This was a multicenter, double-blind, placebo-controlled randomized trial. Between July 2013 and November 2016, the authors recruited 276 people age 18 or over who met diagnostic criteria for borderline personality disorder. Individuals with coexisting bipolar affective disorder or psychosis, those already taking a mood stabilizer, and women at risk of pregnancy were excluded...
April 6, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29571635/lack-of-correlation-between-gastroesophageal-reflux-disease-symptoms-and-esophageal-lesions-after-sleeve-gastrectomy
#14
Emanuele Soricelli, Giovanni Casella, Giovanni Baglio, Roberta Maselli, Ilaria Ernesti, Alfredo Genco
BACKGROUND: The postoperative development or worsening of gastroesophageal reflux disease (GERD) represents the major drawback of laparoscopic sleeve gastrectomy (SG). A GERD diagnosis is often based only on symptoms and proton pump inhibitors (PPI) intake, while objective tests like esophagogastroduodenoscopy and pH measurements are performed less frequently. OBJECTIVES: To evaluate the association between reflux symptoms and GERD-related esophageal lesions. SETTINGS: University hospital, Rome, Italy...
February 13, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29562236/de-novo-mutations-in-regulatory-elements-in-neurodevelopmental-disorders
#15
Patrick J Short, Jeremy F McRae, Giuseppe Gallone, Alejandro Sifrim, Hyejung Won, Daniel H Geschwind, Caroline F Wright, Helen V Firth, David R FitzPatrick, Jeffrey C Barrett, Matthew E Hurles
We previously estimated that 42% of patients with severe developmental disorders carry pathogenic de novo mutations in coding sequences. The role of de novo mutations in regulatory elements affecting genes associated with developmental disorders, or other genes, has been essentially unexplored. We identified de novo mutations in three classes of putative regulatory elements in almost 8,000 patients with developmental disorders. Here we show that de novo mutations in highly evolutionarily conserved fetal brain-active elements are significantly and specifically enriched in neurodevelopmental disorders...
March 29, 2018: Nature
https://www.readbyqxmd.com/read/29519608/the-impact-of-preoperative-investigations-on-the-management-of-bariatric-patients-results-of-a-cohort-of-more-than-1200-cases
#16
Romano Schneider, Ioannis Lazaridis, Marko Kraljević, Christoph Beglinger, Bettina Wölnerhanssen, Ralph Peterli
BACKGROUND: Despite the increasing use of bariatric surgery as the most effective treatment of morbid obesity, there is still no consensus on its preoperative diagnostic workup. The aim of this study was to identify the pathologies of the endoscopic and radiologic investigations before performing bariatric surgery and to evaluate their impact on the patient management. METHODS: Retrospective analysis of prospectively collected data of 1225 consecutive patients who underwent laparoscopic Roux-en-Y gastric bypass (n = 834) or sleeve gastrectomy (n = 391) at our institution...
May 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29511059/association-of-serious-fall-injuries-among-united-states-end-stage-kidney-disease-patients-with-access-to-kidney-transplantation
#17
Laura C Plantinga, Raymond J Lynch, Rachel E Patzer, Stephen O Pastan, C Barrett Bowling
BACKGROUND AND OBJECTIVES: Serious fall injuries in the setting of ESKD may be associated with poor access to kidney transplant. We explored the burden of serious fall injuries among patients on dialysis and patients on the deceased donor waitlist and the associations of these fall injuries with waitlisting and transplantation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our analytic cohorts for the outcomes of ( 1 ) waitlisting and ( 2 ) transplantation included United States adults ages 18-80 years old who ( 1 ) initiated dialysis ( n =183,047) and ( 2 ) were waitlisted for the first time ( n =37,752) in 2010-2013...
April 6, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29487725/microrna-involvement-in-the-onset-and-progression-of-barrett-s-esophagus-a-systematic-review
#18
REVIEW
Reilly J Clark, Michael P Craig, Sangeeta Agrawal, Madhavi Kadakia
Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy that develops from Barrett's esophagus (BE), an intestinal metaplasia of the distal esophagus. microRNAs (miRNAs), short non-coding regulatory RNAs, are frequently dysregulated in BE and are thought to play key roles in the onset of BE and its progression to EAC. miRNAs thus have potential diagnostic and prognostic value and are increasingly being used as cancer biomarkers. This review summarizes the current literature related to miRNAs that are dysregulated in BE within the context of Hedgehog, Notch, MAPK, NF kappa-B, Wnt and epithelial-mesenchymal transition (EMT) signaling which are thought to drive BE onset and progression...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29484934/routine-blood-group-and-antibody-screening-prior-to-emergency-laparoscopy
#19
J Barrett-Lee, J Vatish, M Vazirian-Zadeh, P Waterland
Introduction Studies show that rates of blood transfusion associated with general surgical laparoscopy are low. Currently, there are no national guidelines in the UK regarding blood group and antibody screening (G&S) for patients undergoing emergency laparoscopy. The aim of this study was to assess whether using G&S before emergency laparoscopic general surgery routinely is worthwhile by identifying rates of perioperative transfusion. Methods Data were collected retrospectively on all emergency laparoscopic procedures at a single district general hospital between January 2014 and 31 December 2016...
April 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29440928/early-diagnostic-potential-of-apc-hypermethylation-in-esophageal-cancer
#20
Bujiang Wang, Haojun Song, Haizhong Jiang, Yangbo Fu, Xiaoyun Ding, Chongchang Zhou
Background: The hypermethylation of APC gene is observed in various cancers, including esophageal cancer (EC). However, the association between APC methylation and the initiation and progression of EC is poorly understood. Purpose and methods: The current study systematically reviewed studies on abnormal methylation of APC in EC and quantitatively synthesized 18 studies by meta-analysis involving 1008 ECs, 570 Barrett's esophagus (BE), and 782 controls. Results: Our results showed higher methylation of APC in EC (OR = 23...
2018: Cancer Management and Research
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