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Knee joint loading in knee osteoarthritis

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https://www.readbyqxmd.com/read/28072630/bracing-of-the-reconstructed-and-osteoarthritic-knee-during-high-dynamic-load-tasks
#1
Harvi F Hart, Kay M Crossley, Natalie J Collins, David C Ackland
PURPOSE: Lateral compartment osteoarthritis accompanied by abnormal knee biomechanics are frequently reported in individuals with knee osteoarthritis after anterior cruciate ligament reconstruction (ACLR). The aim of this study was to evaluate changes in knee biomechanics produced by an adjusted and unadjusted varus knee brace during high dynamic loading activities in individuals with lateral knee osteoarthritis after ACLR and valgus malalignment. METHODS: Nineteen participants who had undergone ACLR 5 to 20 years previously and had symptomatic and radiographic lateral knee osteoarthritis with valgus malalignment were assessed...
January 9, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28068837/immediate-effects-of-acupuncture-treatment-on-intra-and-inter-limb-contributions-to-body-support-during-gait-in-patients-with-bilateral-medial-knee-osteoarthritis
#2
Yen-Hung Liu, I-Pin Wei, Ting-Ming Wang, Tung-Wu Lu, Jaung-Geng Lin
Knee osteoarthritis (OA) often leads to altered balance control, joint motion and loading patterns during gait. Acupuncture has been proven to be effective in pain relief but its effects on inter-joint load-sharing for body balance have not been reported. The current study bridged the gap by quantifying the immediate effects of acupuncture on the inter-joint and inter-limb load-sharing in patients with knee OA during level walking in terms of the total support moment (Ms) and the contribution of individual joints to the total support moment...
January 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27989826/development-and-optimization-of-self-assembling-nanosystem-for-intra-articular-delivery-of-indomethacin
#3
Rabab Kamel, Alaa H Salama, Azza A Mahmoud
Osteoarthritis is a propagated debilitating condition affecting patients' quality of life. Intra-articular injection approach was investigated as a localized treatment strategy providing: site-specific delivery, decreased side effects and, increased patient compliance. A 3(2) full factorial experimental design was employed to prepare the indomethacin-loaded self-assembling nanosystems (SANS). The surfactant (Poloxamer 407/Tetronic 90R4) ratio and the poly(lactic-co-glycolic acid) (PLGA) concentration significantly affected encapsulation efficiency and drug release (p<0...
October 28, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27973762/intra-articular-injections-of-hyadd4-g-in-male-professional-soccer-players-with-traumatic-or-degenerative-knee-chondropathy-a-pilot-prospective-study
#4
Pasquale Tamburrino, Enrico Castellacci
BACKGROUND: Knee injuries are very common in some sports and particularly in soccer due to the highly repetitive loading of the mechanical stress involved in this practice. Knee-joint injuries account for 40% of all different kinds of lesions. Traumatic or degenerative patellofemoral or tibialfemoral chondropaties of knee cause disabling symptoms, joint pain and/or dysfunctions. The aim of the study was to evaluate the effects of HYADD4-G, a hydrogel based on a hyaluronic acid derivative, in professional soccer players affected by traumatic or degenerative knee chondropathy...
December 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27936066/the-influence-of-articular-cartilage-thickness-reduction-on-meniscus-biomechanics
#5
Piotr Łuczkiewicz, Karol Daszkiewicz, Jacek Chróścielewski, Wojciech Witkowski, Pawel J Winklewski
OBJECTIVE: Evaluation of the biomechanical interaction between meniscus and cartilage in medial compartment knee osteoarthritis. METHODS: The finite element method was used to simulate knee joint contact mechanics. Three knee models were created on the basis of knee geometry from the Open Knee project. We reduced the thickness of medial cartilages in the intact knee model by approximately 50% to obtain a medial knee osteoarthritis (OA) model. Two variants of medial knee OA model with congruent and incongruent contact surfaces were analysed to investigate the influence of congruency...
2016: PloS One
https://www.readbyqxmd.com/read/27916560/thinning-of-articular-cartilage-after-joint-unloading-or-immobilization-an-experimental-investigation-of-the-pathogenesis-in-mice
#6
M Nomura, N Sakitani, H Iwasawa, Y Kohara, S Takano, Y Wakimoto, H Kuroki, H Moriyama
OBJECTIVE: Moderate mechanical stress generated by normal joint loading and movement is essential for the maintenance of healthy articular cartilage. However, the effects of reduced loading caused by the absence of weight bearing or joint motion on articular cartilage and subchondral bone is still poorly understood. We aimed to characterize morphological and metabolic responses of articular cartilage and subchondral bone to decreased mechanical stress in vivo. METHODS: Mice were subjected to periods of hindlimb unloading by tail suspension or external fixation of the knee joints...
December 1, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27897156/quantitative-evaluation-of-the-mechanical-risks-caused-by-focal-cartilage-defects-in-the-knee
#7
Mikko S Venäläinen, Mika E Mononen, Jari Salo, Lasse P Räsänen, Jukka S Jurvelin, Juha Töyräs, Tuomas Virén, Rami K Korhonen
Focal cartilage lesions can proceed to severe osteoarthritis or remain unaltered even for years. A method to identify high risk defects would be of utmost importance to guide clinical decision making and to identify the patients that are at the highest risk for the onset and progression of osteoarthritis. Based on cone beam computed tomography arthrography, we present a novel computational model for evaluating changes in local mechanical responses around cartilage defects. Our model, based on data obtained from a human knee in vivo, demonstrated that the most substantial alterations around the defect, as compared to the intact tissue, were observed in minimum principal (compressive) strains and shear strains...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27842586/hyaline-cartilage-calcification-of-the-first-metatarsophalangeal-joint-is-associated-with-osteoarthritis-but-independent-of-age-and-bmi
#8
Jan Hubert, Thelonius Hawellek, Sandra Hischke, Jessica Bertrand, Matthias Krause, Klaus Püschel, Wolfgang Rüther, Andreas Niemeier
BACKGROUND: Hyaline cartilage calcification (CC) is associated with osteoarthritis (OA) in hip and knee joints. The first metatarsophalangeal joint (1(st)MTPJ) is frequently affected by OA, but it is unclear if CC occurs in the 1(st)MTPJ. The aim of the present study was to analyze the prevalence of CC of the 1(st)MTPJ in the general population by high-resolution digital contact radiography (DCR) and to determine its association with histological OA severity, age and body mass index (BMI)...
November 15, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27836707/celecoxib-loaded-pea-microspheres-as-an-auto-regulatory-drug-delivery-system-after-intra-articular-injection
#9
Maarten Janssen, Ufuk Tan Timur, Nina Woike, Tim J M Welting, Guy Draaisma, Marion Gijbels, Lodewijk W van Rhijn, George Mihov, Jens Thies, Pieter J Emans
In this study, we investigated the potential of celecoxib-loaded polyester amide (PEA) microspheres as an auto-regulating drug delivery system for the treatment of pain associated with knee osteoarthritis (OA). Celecoxib release from PEA microspheres and inflammation responsive release of a small molecule from PEA was investigated in vitro. Inflammation responsive release of a small molecule from PEA was observed when PEA was exposed to cell lysates obtained from a neutrophil-like Hl-60 cell line. Following a short initial burst release of ~15% of the total drug load in the first days, celecoxib was slowly released throughout a period of >80days...
December 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27836677/the-effect-of-instruction-in-analgesic-use-compared-with-neuromuscular-exercise-on-knee-joint-load-in-patients-with-knee-osteoarthritis-a-randomized-single-blind-controlled-trial
#10
A Holsgaard-Larsen, B Clausen, J Søndergaard, R Christensen, T P Andriacchi, E M Roos
OBJECTIVE: To investigate the effect of a neuro-muscular exercise (NEMEX) therapy program compared with instructions in optimized analgesics and anti-inflammatory drug use (PHARMA), on measures of knee-joint load in people with mild to moderate knee osteoarthritis (OA). We hypothesized that knee joint loading during walking would be reduced by NEMEX and potentially increased by PHARMA. DESIGN: Single-blind, RCT comparing NEMEX therapy twice a week with PHARMA. Participants with mild-to-moderate medial tibiofemoral knee OA were randomly allocated (1:1) to one of two 8-week treatments...
November 9, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27825602/comparison-of-different-material-models-of-articular-cartilage-in-3d-computational-modeling-of-the-knee-data-from-the-osteoarthritis-initiative-oai
#11
Olesya Klets, Mika E Mononen, Petri Tanska, Miika T Nieminen, Rami K Korhonen, Simo Saarakkala
The intricate properties of articular cartilage and the complexity of the loading environment are some of the key challenges in developing models for biomechanical analysis of the knee joint. Fibril-reinforced poroelastic (FRPE) material models have been reported to accurately capture characteristic responses of cartilage during dynamic and static loadings. However, high computational and time costs associated with such advanced models limit applicability of FRPE models when multiple subjects need to be analyzed...
December 8, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27820852/osteoarthritis-in-the-knee-joints-of-g%C3%A3-ttingen-minipigs-after-resection-of-the-anterior-cruciate-ligament-missing-correlation-of-mri-gene-and-protein-expression-with-histological-scoring
#12
Gregor Reisig, Michael Kreinest, Wiltrud Richter, Mechthild Wagner-Ecker, Dietmar Dinter, Ulrike Attenberger, Barbara Schneider-Wald, Stefan Fickert, Markus L Schwarz
INTRODUCTION: The Göttingen Minipig (GM) is used as large animal model in articular cartilage research. The aim of the study was to introduce osteoarthritis (OA) in the GM by resecting the anterior cruciate ligament (ACLR) according to Pond and Nuki, verified by histological and magnetic resonance imaging (MRI) scoring as well as analysis of gene and protein expression. MATERIALS AND METHODS: The eight included skeletally mature female GM were assessed after ACLR in the left and a sham operation in the right knee, which served as control...
2016: PloS One
https://www.readbyqxmd.com/read/27809923/functional-electrical-stimulation-of-gluteus-medius-reduces-the-medial-joint-reaction-force-of-the-knee-during-level-walking
#13
Lance Rane, Anthony Michael James Bull
BACKGROUND: By altering muscular activation patterns, internal forces acting on the human body during dynamic activity may be manipulated. The magnitude of one of these forces, the medial knee joint reaction force (JRF), is associated with disease progression in patients with early osteoarthritis (OA), suggesting utility in its targeted reduction. Increased activation of gluteus medius has been suggested as a means to achieve this. METHODS: Motion capture equipment and force plate transducers were used to obtain kinematic and kinetic data for 15 healthy subjects during level walking, with and without the application of functional electrical stimulation (FES) to gluteus medius...
November 3, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27803343/knee-pain-predicts-subsequent-shoulder-pain-and-the-association-is-mediated-by-leg-weakness-longitudinal-observational-data-from-the-osteoarthritis-initiative
#14
Laura L Laslett, Petr Otahal, Elizabeth M A Hensor, Sarah R Kingsbury, Philip G Conaghan
OBJECTIVE: To assess whether the "spread" of joint pain is related to pain-associated muscle loss in 1 joint leading to increased loading and subsequent pain in other joints. METHODS: Associations between persistent knee pain (pain in 1 or 2 knees over 0-3 years vs no persistent pain) and incident shoulder pain at Year 4 were examined in participants from the longitudinal National Institutes of Health Osteoarthritis Initiative. Associations were assessed using log multinomial modeling, adjusted for age, sex, body mass index, depression score, other lower limb pain, and baseline leg weakness (difficulty standing from a sitting position)...
November 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27775183/asymptomatic-and-symptomatic-individuals-with-the-same-radiographic-evidence-of-knee-osteoarthritis-walk-with-different-knee-moments-and-muscle-activity
#15
Janie L Astephen Wilson, William D Stanish, Cheryl L Hubley-Kozey
There is an established discordance between the structural joint damage and clinical symptoms of knee osteoarthritis; however, there has been little investigation into the differences in joint level biomechanics and muscle activation patterns during gait between symptomatic and asymptomatic individuals with the same radiographic evidence of osteoarthritis. The objective of this study was to examine three-dimensional knee joint biomechanics and muscle activation differences during gait between asymptomatic and symptomatic individuals with radiographic knee osteoarthritis...
October 24, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27761624/comparison-of-the-efficiency-of-an-extra-articular-absorber-system-and-high-tibial-osteotomy-for-unloading-the-medial-knee-compartment-an-in-vitro-study
#16
Gerrit Bode, Ferdinand Kloos, Matthias J Feucht, Benjamin Fleischer, Norbert Südkamp, Philipp Niemeyer, Christoph Becher
PURPOSE: The unloading effect of an extra-articular absorber system on the knee joint medial compartment was compared with high tibial osteotomy (HTO) under physiological conditions in vitro. METHODS: Seven fresh-frozen cadaveric knees were used to test isokinetic flexion-extension motions under physiological loading using a biomechanical knee simulator. Tibiofemoral area contact and peak contact pressures were measured using pressure-sensitive film in the untreated medial compartment...
October 19, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27747918/predictors-of-knee-joint-loading-after-anterior-cruciate-ligament-reconstruction
#17
Elizabeth Wellsandt, Ashutosh Khandha, Kurt Manal, Michael J Axe, Thomas S Buchanan, Lynn Snyder-Mackler
Anterior cruciate ligament (ACL) injury results in altered knee joint mechanics which frequently continue even after ACL reconstruction. The persistence of altered mechanical loading of the knee is of concern due to its likely role in the development of post-traumatic osteoarthritis (OA). Joint contact forces are associated with post-traumatic OA development, but evaluation of factors influencing the magnitude of contact forces after ACL injury is needed to advance current strategies aimed at preventing post-traumatic OA...
October 17, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27729289/association-of-baseline-knee-sagittal-dynamic-joint-stiffness-during-gait-and-2-year-patellofemoral-cartilage-damage-worsening-in-knee-osteoarthritis
#18
Alison H Chang, Joan S Chmiel, Orit Almagor, Ali Guermazi, Pottumarthi V Prasad, Kirsten C Moisio, Laura Belisle, Yunhui Zhang, Karen Hayes, Leena Sharma
OBJECTIVE: Knee sagittal dynamic joint stiffness (DJS) describes the biomechanical interaction between change in external knee flexion moment and flexion angular excursion during gait. In theory, greater DJS may particularly stress the patellofemoral (PF) compartment and thereby contribute to PF osteoarthritis (OA) worsening. We hypothesized that greater baseline knee sagittal DJS is associated with PF cartilage damage worsening 2 years later. METHODS: Participants all had OA in at least one knee...
October 8, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27725941/exercise-alters-gait-pattern-but-not-knee-load-in-patients-with-knee-osteoarthritis
#19
Ssu-Yu Chang, Yi-Jia Lin, Wei-Chun Hsu, Lin-Fen Hsieh, Yuan-Hsiang Lin, Chao-Chin Chang, You-Cai Chou, Li-Fei Chen
Six female patients with bilateral medial knee OA and 6 healthy controls were recruited. Patients with knee OA received a 6-week physiotherapist-supervised and home-based exercise program. Outcome measures, including the Western Ontario and McMaster Universities Arthritis Index and Short Form-36 Health Survey as well as objective biomechanical indices were obtained at baseline and follow-up. After treatment, no significant difference was observed in the knee abductor moment (KAM), lever arm, and ground reaction force...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27693959/long-term-effects-of-lateral-wedge-orthotics-on-hip-and-ankle-joint-space-widths
#20
Mehmet E Tezcan, Berna Goker, Roy Lidtke, Joel A Block
BACKGROUND: Lateral wedge insoles have been used for the treatment of medial knee osteoarthritis (OA) and have been shown to reduce loading of the medial compartment of the knee. However, as the entire lower extremity acts as a single kinetic chain, altering the biomechanics of the knee may also have significant effects at the ankles or hips. We aimed to evaluate the effects of lateral wedge orthotics on ankle and hip joints, compared to neutral orthotics, by assessing the changes in joint space width (JSW) during 36 months of continuous use...
January 2017: Gait & Posture
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