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Knee joint loading in knee osteoarthritis

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https://www.readbyqxmd.com/read/28229430/differences-in-biomarkers-of-cartilage-matrix-turnover-and-their-changes-over-2%C3%A2-years-in-adolescent-and-adult-volleyball-athletes
#1
Heide Boeth, Aoife MacMahon, A Robin Poole, Frank Buttgereit, Patrik Önnerfjord, Pilar Lorenzo, Cecilia Klint, Anna Pramhed, Georg N Duda
BACKGROUND: This study aimed the feasibility to assess longitudinal changes in biomarkers of cartilage turnover and to determine their relationship with patient-rated outcomes over 2 years in volleyball athletes. METHODS: Thirty-seven athletes were studied: 18 adolescents (age 15.9 ± 0.64 years) in a 2-year intensive volleyball training program and 19 adult recreational volleyball players (age 46.5 ± 4.9 years). Blood and serum samples were taken at baseline (BL) and 2-year follow-up (FU)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28227239/a-smart-cane-with-vibrotactile-biofeedback-improves-cane-loading-for-people-with-knee-osteoarthritis
#2
Rebecca L Routson, Marcus Bailey, Isabelle Pumford, Joseph M Czerniecki, Patrick M Aubin, Rebecca L Routson, Marcus Bailey, Isabelle Pumford, Joseph M Czerniecki, Patrick M Aubin, Patrick M Aubin, Joseph M Czerniecki, Rebecca L Routson, Marcus Bailey, Isabelle Pumford
Nine million adults have symptomatic knee osteoarthritis (OA) in the U.S. and almost half of those people have a walking aid such as a cane. Proper cane loading (e.g. 15% body weight [BW]) can reduce knee loading and may slow OA progression. The purpose of this study was to investigate the efficacy of a novel smart cane with vibrotactile biofeedback that aims to facilitate increased cane loading. Ten subjects with knee OA performed a 50 m hallway walk test under four conditions: 1) naïve, 2) conventional cane with verbal instruction, 3) smart cane, and 4) conventional cane post smart cane...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226296/the-relationship-between-external-knee-moments-and-muscle-co-activation-in-subjects-with-medial-knee-osteoarthritis
#3
Luiz Fernando Approbato Selistre, Stela Márcia Mattiello, Theresa Helissa Nakagawa, Glaucia Helena Gonçalves, Marina Petrella, Richard Keith Jones
PURPOSE: External knee moments are reliable to measure knee load but it does not take into account muscle activity. Considering that muscle co-activation increases compressive forces at the knee joint, identifying relationships between muscle co-activations and knee joint load would complement the investigation of the knee loading in subjects with knee osteoarthritis. The purpose of this study was to identify relationships between muscle co-activation and external knee moments during walking in subjects with medial knee osteoarthritis...
January 18, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28222057/effects-of-toe-in-and-wider-step-width-in-stair-ascent-with-different-knee-alignments
#4
Hunter J Bennett, Songning Zhang, Guangping Shen, Joshua T Weinhandl, Max R Paquette, Jeffrey Reinbolt, Dawn P Coe
PURPOSE: Toe-in (TI) and toe-in with wider step width (TIW) gait modifications have successfully reduced the internal peak knee adduction moment (KAM) during level walking and stair ascent tasks, respectively, for healthy and knee osteoarthritis populations. However, the concurrent effects of these modifications have not previously been combined to reduce both the first and the second peak KAM during stair ascent or tested among the different knee alignment groups. Therefore, the purpose of this study was to examine effects of TI and TIW gait modifications on knee biomechanics during stair ascent in individuals with varus, neutral, and valgus knee alignments...
March 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28214426/reduced-step-length-reduces-knee-joint-contact-forces-during-running-following-anterior-cruciate-ligament-reconstruction-but-does-not-alter-inter-limb-asymmetry
#5
Collin D Bowersock, Richard W Willy, Paul DeVita, John D Willson
BACKGROUND: Anterior cruciate ligament reconstruction is associated with early onset knee osteoarthritis. Running is a typical activity following this surgery, but elevated knee joint contact forces are thought to contribute to osteoarthritis degenerative processes. It is therefore clinically relevant to identify interventions to reduce contact forces during running among individuals after anterior cruciate ligament reconstruction. The primary purpose of this study was to evaluate the effect of reducing step length during running on patellofemoral and tibiofemoral joint contact forces among people with a history of anterior cruciate ligament reconstruction...
February 10, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28213953/the-effects-of-acl-graft-placement-on-in-vivo-knee-function-and-cartilage-thickness-distributions
#6
REVIEW
Louis E DeFrate
Injuries to the anterior cruciate ligament (ACL) frequently lead to early-onset osteoarthritis. Despite advancement in surgical techniques, ACL reconstruction has a limited ability to prevent these degenerative changes. While previous studies have investigated knee function after ACL reconstruction, in vivo investigations of the effects of graft placement on in vivo joint function and cartilage health are limited. This review presents a series of studies that used novel imaging and 3D modeling techniques to determine the in vivo placement of the ACL graft on the femur using two different ACL reconstruction techniques...
February 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28189095/effects-of-toe-out-and-toe-in-gait-with-varying-walking-speeds-on-knee-joint-mechanics-and-lower-limb-energetics
#7
Soobia Saad Khan, Saad Jawaid Khan, Juliana Usman
Toe-out/-in gait has been prescribed in reducing knee joint load to medial knee osteoarthritis patients. This study focused on the effects of toe-out/-in at different walking speeds on first peak knee adduction moment (fKAM), second peak KAM (sKAM), knee adduction angular impulse (KAAI), net mechanical work by lower limb as well as joint-level contribution to the total limb work during level walking. Gait analysis of 20 healthy young adults was done walking at pre-defined normal (1.18m/s), slow (0.85m/s) and fast (1...
January 27, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28168120/medial-knee-joint-contact-force-in-the-intact-limb-during-walking-in-recently-ambulatory-service-members-with-unilateral-limb-loss-a-cross-sectional-study
#8
Ross H Miller, Rebecca L Krupenevich, Alison L Pruziner, Erik J Wolf, Barri L Schnall
BACKGROUND: Individuals with unilateral lower limb amputation have a high risk of developing knee osteoarthritis (OA) in their intact limb as they age. This risk may be related to joint loading experienced earlier in life. We hypothesized that loading during walking would be greater in the intact limb of young US military service members with limb loss than in controls with no limb loss. METHODS: Cross-sectional instrumented gait analysis at self-selected walking speeds with a limb loss group (N = 10, age 27 ± 5 years, 170 ± 36 days since last surgery) including five service members with transtibial limb loss and five with transfemoral limb loss, all walking independently with their first prosthesis for approximately two months...
2017: PeerJ
https://www.readbyqxmd.com/read/28155677/finite-element-analysis-of-the-valgus-knee-joint-of-an-obese-child
#9
Jun Sun, Songhua Yan, Yan Jiang, Duo Wai-Chi Wong, Ming Zhang, Jizhou Zeng, Kuan Zhang
BACKGROUND: Knee valgus and varus morbidity is at the second top place in children lower limb deformity diseases. It may cause abnormal stress distribution. The magnitude and location of contact forces on tibia plateau during gait cycle have been indicated as markers for risk of osteoarthritis. So far, few studies reported the contact stress and force distribution on tibial plateau of valgus knee of children. METHODS: To estimate the contact stresses and forces on tibial plateau of an 8-year old obese boy with valgus knee and a 7-year old healthy boy, three-dimensional (3D) finite element (FE) models of their left knee joints were developed...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28145908/joint-loading-in-runners-does-not-initiate-knee-osteoarthritis
#10
Ross H Miller
Runners do not have a greater prevalence of knee osteoarthritis (OA) than non-runners. The hypothesis that joint loads in running do not cause OA is forwarded. Two mechanisms are proposed: 1) cumulative load, which is surprisingly low in running, is more important for OA risk than peak load, and 2) running conditions cartilage to withstand the mechanical stresses of running.
January 31, 2017: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/28126693/differences-in-knee-adduction-moment-between-healthy-subjects-and-patients-with-osteoarthritis-depend-on-the-knee-axis-definition
#11
S Meireles, F De Groote, S Van Rossom, S Verschueren, I Jonkers
OBJECTIVE: This study, firstly, investigates the effect of using an anatomical versus a functional axis of rotation (FAR) on knee adduction moment (KAM) in healthy subjects and patients with knee osteoarthritis (KOA). Secondly, this study reports KAM for models with FAR calculated using weight-bearing and non-weight-bearing motion. DESIGN: Three musculoskeletal models were created using OpenSim with different knee axis of rotation (AR): transepicondylar axis (TEA); FAR calculated based on SARA algorithm using a weight-bearing motion (wFAR) and a non-weight-bearing motion (nwFAR)...
January 19, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28121190/the-biology-of-meniscal-pathology-in-osteoarthritis-and-its-contribution-to-joint-disease-beyond-simple-mechanics
#12
James Melrose, Emily S Fuller, Christopher B Little
The meniscal cartilages in the knee function to improve congruity of the medial and lateral femoro-tibial joints, and play critical roles in load distribution and joint stability. Meniscal tears of various configurations are one of the most common conditions of the knee, and are associated with an increased risk of developing osteoarthritis (OA). While this risk has been largely attributed to loss of the biomechanical functions of the menisci, there is accumulating evidence suggesting that other aspects of meniscal biology may play a role in determining the long-term consequences of meniscal damage for joint health...
January 25, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28120496/effects-of-active-feedback-gait-retraining-to-produce-a-medial-weight-transfer-at-the-foot-in-subjects-with-symptomatic-medial-knee-osteoarthritis
#13
Jennifer C Erhart-Hledik, Jessica L Asay, Caitlin Clancy, Constance R Chu, Thomas P Andriacchi
This study aimed to determine if active feedback gait retraining to produce a medial weight transfer at the foot significantly reduces the knee adduction moment in subjects with medial compartment knee osteoarthritis. Secondarily, changes in peak knee flexion moment, frontal plane knee and ankle kinematics, and center of pressure were investigated. Ten individuals with medial compartment knee osteoarthritis (9 males; age: 65.3 ± 9.8 years; BMI: 27.8 ± 3.0 kg/m(2) ) were tested at self-selected normal and fast speeds in two conditions: Intervention, with an active feedback device attached to the shoe of their more affected leg, and control, with the device de-activated...
January 24, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28093922/toll-like-receptors-and-their-soluble-forms-differ-in-the-knee-and-thumb-basal-osteoarthritic-joints
#14
Goncalo Barreto, Jerker Sandelin, Abdelhakim Salem, Dan C Nordström, Eero Waris
Background and purpose - Although the pathogenesis of osteoarthritis (OA) is not well understood, chondrocyte-mediated inflammatory responses (triggered by the activation of innate immune receptors by damage-associated molecules) are thought to be involved. We examined the relationship between Toll-like receptors (TLRs) and OA in cartilage from 2 joints differing in size and mechanical loading: the first carpometacarpal (CMC-I) and the knee. Patients and methods - Samples of human cartilage obtained from OA CMC-I and knee joints were immunostained for TLRs (1-9) and analyzed using histomorphometry and principal component analysis (PCA)...
January 17, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28072630/bracing-of-the-reconstructed-and-osteoarthritic-knee-during-high-dynamic-load-tasks
#15
Harvi F Hart, Kay M Crossley, Natalie J Collins, David C Ackland
PURPOSE: Lateral compartment osteoarthritis accompanied by abnormal knee biomechanics are frequently reported in individuals with knee osteoarthritis after anterior cruciate ligament reconstruction (ACLR). The aim of this study was to evaluate changes in knee biomechanics produced by an adjusted and unadjusted varus knee brace during high dynamic loading activities in individuals with lateral knee osteoarthritis after ACLR and valgus malalignment. METHODS: Nineteen participants who had undergone ACLR 5 to 20 years previously and had symptomatic and radiographic lateral knee osteoarthritis with valgus malalignment were assessed...
January 9, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28068837/immediate-effects-of-acupuncture-treatment-on-intra-and-inter-limb-contributions-to-body-support-during-gait-in-patients-with-bilateral-medial-knee-osteoarthritis
#16
Yen-Hung Liu, I-Pin Wei, Ting-Ming Wang, Tung-Wu Lu, Jaung-Geng Lin
Knee osteoarthritis (OA) often leads to altered balance control, joint motion and loading patterns during gait. Acupuncture has been proven to be effective in pain relief but its effects on inter-joint load-sharing for body balance have not been reported. The current study bridged the gap by quantifying the immediate effects of acupuncture on the inter-joint and inter-limb load-sharing in patients with knee OA during level walking in terms of the total support moment (Ms) and the contribution of individual joints to the total support moment...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27989826/development-and-optimization-of-self-assembling-nanosystem-for-intra-articular-delivery-of-indomethacin
#17
Rabab Kamel, Alaa H Salama, Azza A Mahmoud
Osteoarthritis is a propagated debilitating condition affecting patients' quality of life. Intra-articular injection approach was investigated as a localized treatment strategy providing: site-specific delivery, decreased side effects and, increased patient compliance. A 3(2) full factorial experimental design was employed to prepare the indomethacin-loaded self-assembling nanosystems (SANS). The surfactant (Poloxamer 407/Tetronic 90R4) ratio and the poly(lactic-co-glycolic acid) (PLGA) concentration significantly affected encapsulation efficiency and drug release (p<0...
October 28, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27973762/intra-articular-injections-of-hyadd4-g-in-male-professional-soccer-players-with-traumatic-or-degenerative-knee-chondropathy-a-pilot-prospective-study
#18
Pasquale Tamburrino, Enrico Castellacci
BACKGROUND: Knee injuries are very common in some sports and particularly in soccer due to the highly repetitive loading of the mechanical stress involved in this practice. Knee-joint injuries account for 40% of all different kinds of lesions. Traumatic or degenerative patellofemoral or tibialfemoral chondropaties of knee cause disabling symptoms, joint pain and/or dysfunctions. The aim of the study was to evaluate the effects of HYADD4-G, a hydrogel based on a hyaluronic acid derivative, in professional soccer players affected by traumatic or degenerative knee chondropathy...
December 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27936066/the-influence-of-articular-cartilage-thickness-reduction-on-meniscus-biomechanics
#19
Piotr Łuczkiewicz, Karol Daszkiewicz, Jacek Chróścielewski, Wojciech Witkowski, Pawel J Winklewski
OBJECTIVE: Evaluation of the biomechanical interaction between meniscus and cartilage in medial compartment knee osteoarthritis. METHODS: The finite element method was used to simulate knee joint contact mechanics. Three knee models were created on the basis of knee geometry from the Open Knee project. We reduced the thickness of medial cartilages in the intact knee model by approximately 50% to obtain a medial knee osteoarthritis (OA) model. Two variants of medial knee OA model with congruent and incongruent contact surfaces were analysed to investigate the influence of congruency...
2016: PloS One
https://www.readbyqxmd.com/read/27916560/thinning-of-articular-cartilage-after-joint-unloading-or-immobilization-an-experimental-investigation-of-the-pathogenesis-in-mice
#20
M Nomura, N Sakitani, H Iwasawa, Y Kohara, S Takano, Y Wakimoto, H Kuroki, H Moriyama
OBJECTIVE: Moderate mechanical stress generated by normal joint loading and movement is essential for the maintenance of healthy articular cartilage. However, the effects of reduced loading caused by the absence of weight bearing or joint motion on articular cartilage and subchondral bone is still poorly understood. We aimed to characterize morphological and metabolic responses of articular cartilage and subchondral bone to decreased mechanical stress in vivo. METHODS: Mice were subjected to periods of hindlimb unloading by tail suspension or external fixation of the knee joints...
December 1, 2016: Osteoarthritis and Cartilage
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