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Knee joint loading in knee osteoarthritis

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https://www.readbyqxmd.com/read/28437567/people-with-patellofemoral-oa-walk-with-different-pelvic-and-hip-kinematics-compared-to-healthy-aged-matched-controls
#1
Kay M Crossley, Anthony G Schache, Hannah Ozturk, Jonathan Lentzos, Melissa Munanto, Marcus G Pandy
Objective, Patellofemoral joint (PFJ) osteoarthritis (OA) is common, yet little is known about how this condition influences lower-limb biomechanical function. This study compared pelvis and lower-limb kinematics in people with and without PFJOA., Methods, Sixty-nine participants (64% women, mean age 56±10 years) with anterior knee pain aggravated by PFJ loaded activities (stair ambulation, rising from sitting, squatting) and radiographic lateral PFJOA on skyline radiographs were compared with 18 controls (78% women, mean age 53±7 years) with no lower-limb pain or radiographic OA...
April 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28436878/biofeedback-for-gait-retraining-based-on-real-time-estimation-of-tibiofemoral-joint-contact-forces
#2
Claudio Pizzolato, Monica Reggiani, David J Saxby, Elena Ceseracciu, Luca Modenese, David G Lloyd
Biofeedback assisted rehabilitation and intervention technologies have the potential to modify clinically relevant biomechanics. Gait retraining has been used to reduce the knee adduction moment, a surrogate of medial tibiofemoral joint loading often used in knee osteoarthritis research. In this study we present an electromyogram-driven neuromusculoskeletal model of the lower-limb to estimate, in real-time, the tibiofemoral joint loads. The model included 34 musculotendon units spanning the hip, knee, and ankle joints...
April 18, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28406954/therapeutic-efficacy-of-intra-articular-hyaluronan-derivative-and-platelet-rich-plasma-in-mice-following-axial-tibial-loading
#3
Xin Duan, Linda J Sandell, Nobuaki Chinzei, Nilsson Holguin, Matthew J Silva, Antonella Schiavinato, Muhammad Farooq Rai
OBJECTIVE: To investigate the therapeutic potential of intra-articular hyaluronan-derivative HYADD® 4-G and/or platelet-rich plasma (PRP) in a mouse model of non-invasive joint injury. METHODS: Non-invasive axial tibial loading was used to induce joint injury in 10-week-old C57BL/6J mice (n = 86). Mice underwent a single loading of either 6 Newton (N) or 9N axial tibial compression. HYADD® 4-G was injected intra-articularly at 8 mg/mL or 15 mg/mL either before or after loading with or without PRP...
2017: PloS One
https://www.readbyqxmd.com/read/28396901/-%C3%A2-biomechanics-of-new-implants-for-hto
#4
D Pape, A Diffo Kaze, A Hoffmann, S Maas
Biomechanical characteristics of 5 tibial osteotomy plates for the treatment of medial knee joint osteoarthritis were examined. Fourth-generation tibial bone composites underwent a medial open-wedge high tibial osteotomy, using TomoFix™ standard, PEEKPower®, ContourLock®, TomoFix™ small stature plates, and iBalance® implants. Static compression load to failure and load-controlled cyclic fatigue failure tests were performed. All plates had sufficient stability up to 2400 N in the static compression load to failure tests...
April 10, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28366841/digital-image-correlation-aided-mechanical-characterization-of-the-anteromedial-and-posterolateral-bundles-of-the-anterior-cruciate-ligament
#5
Kaitlyn Mallett, Ellen M Arruda
The anterior cruciate ligament (ACL) is one of the most commonly injured soft tissue structures in the articular knee joint, often requiring invasive surgery for patients to restore pre-injury knee kinematics. There is a pressing need to understand the role of the ACL in knee function, in order to select proper replacements. Digital image correlation (DIC), a non-contact full field displacement measurement technique, is an established tool for evaluating non-biological materials. The application of DIC to soft tissues has been in the nascent stages, largely due to patterning challenges of such materials...
March 30, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28355681/a-biomechanical-study-of-two-distinct-methods-of-anterior-cruciate-ligament-rupture-and-a-novel-surgical-reconstruction-technique-in-a-small-animal-model-of-posttraumatic-osteoarthritis
#6
Austin J Ramme, Matin S Lendhey, Eric J Strauss, Oran D Kennedy
Small animal models are critical for studies of sports-related knee injury and disease such as posttraumatic osteoarthritis (PTOA) following anterior cruciate ligament (ACL) rupture. In such models, ACL damage can be achieved by surgical transection or, using a more recent innovation, by noninvasive biomechanical means. Whether these approaches differentially alter normal mechanics is unknown. Furthermore, while surgical reconstruction of ruptured ACL can greatly improve joint stability, its effect on PTOA development is also unclear...
March 29, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28345597/post-traumatic-osteoarthritis-in-mice-following-mechanical-injury-to-the-synovial-joint
#7
Muhammad Farooq Rai, Xin Duan, James D Quirk, Nilsson Holguin, Eric J Schmidt, Nobuaki Chinzei, Matthew J Silva, Linda J Sandell
We investigated the spectrum of lesions characteristic of post-traumatic osteoarthritis (PTOA) across the knee joint in response to mechanical injury. We hypothesized that alteration in knee joint stability in mice reproduces molecular and structural features of PTOA that would suggest potential therapeutic targets in humans. The right knees of eight-week old male mice from two recombinant inbred lines (LGXSM-6 and LGXSM-33) were subjected to axial tibial compression. Three separate loading magnitudes were applied: 6N, 9N, and 12N...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345407/knee-menisci
#8
James Kevin Bryceland, Andrew John Powell, Thomas Nunn
The menisci of the knees are semicircular fibrocartilaginous structures consisting of a hydrophilic extracellular matrix containing a network of collagen fibers, glycoproteins, and proteoglycans maintained by a cellular component. The menisci are responsible for more than 50% of load transmission across the knee and increase joint congruity thereby also aiding in fluid film lubrication of the joint. In the United Kingdom, meniscal tears are the most common form of intra-articular knee injury and one of the commonest indications for orthopedic intervention...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28326927/glial-activation-in-the-collagenase-model-of-nociception-associated-with-osteoarthritis
#9
Sara Adães, Lígia Almeida, Catarina S Potes, Ana Rita Ferreira, José M Castro-Lopes, Joana Ferreira-Gomes, Fani L Neto
Background Experimental osteoarthritis entails neuropathic-like changes in dorsal root ganglia (DRG) neurons. Since glial activation has emerged as a key player in nociception, being reported in numerous models of neuropathic pain, we aimed at evaluating if glial cell activation may also occur in the DRG and spinal cord of rats with osteoarthritis induced by intra-articular injection of collagenase. Methods Osteoarthritis was induced by two injections, separated by three days, of 500 U of type II collagenase into the knee joint of rats...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28323351/baseline-knee-adduction-moment-interacts-with-body-mass-index-to-predict-loss-of-medial-tibial-cartilage-volume-over-2-5-years-in-knee-osteoarthritis
#10
Nicholas M Brisson, Emily G Wiebenga, Paul W Stratford, Karen A Beattie, Saara Totterman, José G Tamez-Peña, Jack P Callaghan, Jonathan D Adachi, Monica R Maly
This study aimed to determine the extent to which changes over 2.5 years in medial knee cartilage thickness and volume were predicted by: (1) Peak values of the knee adduction (KAM) and flexion moments; and (2) KAM impulse and loading frequency, representing cumulative load, after controlling for age, sex and body mass index (BMI). Adults with clinical knee osteoarthritis participated. At baseline and approximately 2.5 years follow-up, cartilage thickness and volume of the medial tibia and femur were segmented from magnetic resonance imaging scans...
March 21, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28302318/regional-differences-of-tibial-and-femoral-cartilage-in-the-chondrocyte-gene-expression-immunhistochemistry-and-composite-in-different-stages-of-osteoarthritis
#11
A Lahm, D Dabravolski, H Spank, H Merk, J Esser, R Kasch
The function of articular cartilage as an avascular tissue is mainly served by collagen type II and proteoglycan molecules. Within this matrix homeostasis between production and breakdown of the matrix is exceptionally sensitive. The current study was conducted to identify regional differences in specific alterations in cartilage composition during the osteoarthritic process of the human knee joint. Therefor the changes in the expression of the key molecules of the extracellular matrix were measured in dependence of the anatomical side (femoral vs tibial) and associated with immunohistochemistry and quantitative measurement...
April 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28301825/combined-versus-individual-effects-of-a-valgus-knee-brace-and-lateral-wedge-foot-orthotic-during-stair-use-in-patients-with-knee-osteoarthritis
#12
Rebecca Moyer, Trevor Birmingham, Colin Dombroski, Robert Walsh, J Robert Giffin
The aim of this study was to investigate the combined and individual biomechanical effects of a valgus knee brace and a lateral wedge foot orthotic during stair ascent and descent in patients with knee osteoarthritis (OA). Thirty-five patients with varus alignment and medial knee OA were prescribed a custom valgus knee brace and lateral wedge foot orthotic. Knee angles and moments in the frontal and sagittal planes were determined from 3D gait analysis completed under four randomized conditions: (1) control (no knee brace or foot orthotic), (2) knee brace, (3) foot orthotic, and (4) combined knee brace and foot orthotic...
March 1, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28274742/a-hyaluronic-acid-based-hydrogel-enabling-cd44-mediated-chondrocyte-binding-and-gapmer-oligonucleotide-release-for-modulation-of-gene-expression-in-osteoarthritis
#13
Yunpeng Cai, Elena López-Ruiz, Jesper Wengel, Laura B Creemers, Kenneth A Howard
Hyaluronic acid (HA) is an attractive biomaterial for osteoarthritis (OA) treatment due to inherent functional and compatibility properties as an endogenous knee joint component. In this work, we describe a HA-based hydrogel with the dual functionality of increased CD44-dependent chondrocyte binding and controlled release of gapmer antisense oligonucleotides for unassisted cellular entry and subsequent gene silencing activity. A Schiff base-mediated gelation method was used to produce a panel of hydrogels varying in the aldehyde-modified HA (900kDa) to chitosan ratios (3:7, 5:5 and 7:3) for identifying designs displaying optimal engagement of OA patient-derived CD44-expressing chondrocytes...
March 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28269026/a-smart-cane-with-vibrotactile-biofeedback-improves-cane-loading-for-people-with-knee-osteoarthritis
#14
Rebecca L Routson, Marcus Bailey, Isabelle Pumford, Joseph M Czerniecki, Patrick M Aubin
Nine million adults have symptomatic knee osteoarthritis (OA) in the U.S. and almost half of those people have a walking aid such as a cane. Proper cane loading (e.g. 15% body weight [BW]) can reduce knee loading and may slow OA progression. The purpose of this study was to investigate the efficacy of a novel smart cane with vibrotactile biofeedback that aims to facilitate increased cane loading. Ten subjects with knee OA performed a 50 m hallway walk test under four conditions: 1) naïve, 2) conventional cane with verbal instruction, 3) smart cane, and 4) conventional cane post smart cane...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267190/changes-in-joint-contact-mechanics-in-a-large-quadrupedal-animal-model-after-partial-meniscectomy-and-a-focal-cartilage-injury
#15
David J Heckelsmiller, M James Rudert, Thomas E Baer, Douglas R Pedersen, Douglas C Fredericks, Jessica E Goetz
Acute mechanical damage and the resulting joint contact abnormalities are central to the initiation and progression of post-traumatic osteoarthritis (PTOA). Study of PTOA is typically performed in vivo with replicate animals using artificially induced injury features. The goal of this work was to measure changes in a joint contact stress in the knee of a large quadruped after creation of a clinically realistic overload injury and a focal cartilage defect. Whole-joint overload was achieved by excising a 5-mm wedge of the anterior medial meniscus...
May 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28258176/the-patellofemoral-pain-and-osteoarthritis-subscale-of-the-koos-koos-pf-development-and-validation-using-the-cosmin-checklist
#16
Kay M Crossley, Erin M Macri, Sallie M Cowan, Natalie J Collins, Ewa M Roos
BACKGROUND: Patellofemoral pain and osteoarthritis are prevalent and associated with substantial pain and functional impairments. Patient-reported outcome measures (PROMs) are recommended for research and clinical use, but no PROMs are specific for patellofemoral osteoarthritis, and existing PROMs for patellofemoral pain have methodological limitations. This study aimed to develop a new subscale of the Knee injury and Osteoarthritis Outcome Score for patellofemoral pain and osteoarthritis (KOOS-PF), and evaluate its measurement properties...
March 3, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28237185/relationship-between-t1rho-magnetic-resonance-imaging-synovial-fluid-biomarkers-and-the-biochemical-and-biomechanical-properties-of-cartilage
#17
Courtney C Hatcher, Amber T Collins, Sophia Y Kim, Lindsey C Michel, William C Mostertz, Sophia N Ziemian, Charles E Spritzer, Farshid Guilak, Louis E DeFrate, Amy L McNulty
Non-invasive techniques for quantifying early biochemical and biomechanical changes in articular cartilage may provide a means of more precisely assessing osteoarthritis (OA) progression. The goals of this study were to determine the relationship between T1rho magnetic resonance (MR) imaging relaxation times and changes in cartilage composition, cartilage mechanical properties, and synovial fluid biomarker levels and to demonstrate the application of T1rho imaging to evaluate cartilage composition in human subjects in vivo...
April 11, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28229430/differences-in-biomarkers-of-cartilage-matrix-turnover-and-their-changes-over-2%C3%A2-years-in-adolescent-and-adult-volleyball-athletes
#18
Heide Boeth, Aoife MacMahon, A Robin Poole, Frank Buttgereit, Patrik Önnerfjord, Pilar Lorenzo, Cecilia Klint, Anna Pramhed, Georg N Duda
BACKGROUND: This study aimed the feasibility to assess longitudinal changes in biomarkers of cartilage turnover and to determine their relationship with patient-rated outcomes over 2 years in volleyball athletes. METHODS: Thirty-seven athletes were studied: 18 adolescents (age 15.9 ± 0.64 years) in a 2-year intensive volleyball training program and 19 adult recreational volleyball players (age 46.5 ± 4.9 years). Blood and serum samples were taken at baseline (BL) and 2-year follow-up (FU)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28227239/a-smart-cane-with-vibrotactile-biofeedback-improves-cane-loading-for-people-with-knee-osteoarthritis
#19
Rebecca L Routson, Marcus Bailey, Isabelle Pumford, Joseph M Czerniecki, Patrick M Aubin, Rebecca L Routson, Marcus Bailey, Isabelle Pumford, Joseph M Czerniecki, Patrick M Aubin, Patrick M Aubin, Joseph M Czerniecki, Rebecca L Routson, Marcus Bailey, Isabelle Pumford
Nine million adults have symptomatic knee osteoarthritis (OA) in the U.S. and almost half of those people have a walking aid such as a cane. Proper cane loading (e.g. 15% body weight [BW]) can reduce knee loading and may slow OA progression. The purpose of this study was to investigate the efficacy of a novel smart cane with vibrotactile biofeedback that aims to facilitate increased cane loading. Ten subjects with knee OA performed a 50 m hallway walk test under four conditions: 1) naïve, 2) conventional cane with verbal instruction, 3) smart cane, and 4) conventional cane post smart cane...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226296/the-relationship-between-external-knee-moments-and-muscle-co-activation-in-subjects-with-medial-knee-osteoarthritis
#20
Luiz Fernando Approbato Selistre, Stela Márcia Mattiello, Theresa Helissa Nakagawa, Glaucia Helena Gonçalves, Marina Petrella, Richard Keith Jones
PURPOSE: External knee moments are reliable to measure knee load but it does not take into account muscle activity. Considering that muscle co-activation increases compressive forces at the knee joint, identifying relationships between muscle co-activations and knee joint load would complement the investigation of the knee loading in subjects with knee osteoarthritis. The purpose of this study was to identify relationships between muscle co-activation and external knee moments during walking in subjects with medial knee osteoarthritis...
January 18, 2017: Journal of Electromyography and Kinesiology
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