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Knee joint loading in knee osteoarthritis

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https://www.readbyqxmd.com/read/29683374/finite-element-analysis-of-the-effect-of-high-tibial-osteotomy-correction-angle-on-articular-cartilage-loading
#1
Zahra Trad, Abdelwahed Barkaoui, Moez Chafra, João Manuel Rs Tavares
Osteoarthritis is a globally common disease that imposes a considerable ongoing health and economic burden on the socioeconomic system. As more and more biomechanical factors have been explored, malalignment of the lower limb has been found to influence the load distribution across the articular surface of the knee joint substantially. In this work, a three-dimensional finite element analysis was carried out to investigate the effect of varying the high tibial osteotomy correction angle on the stress distribution in both compartments of the human knee joint...
April 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29673934/foot-structure-and-knee-joint-kinetics-during-walking-with-and-without-wedged-footwear-insoles
#2
Ryan T Lewinson, Ryan Madden, Anthony Killick, John W Wannop, J Preston Wiley, Victor M Y Lun, Chirag Patel, Jeremy M LaMothe, Darren J Stefanyshyn
The relationship between static foot structure characteristics and knee joint biomechanics during walking, or the biomechanical response to wedged insoles are currently unknown. In this study, 3D foot scanning, dual X-ray absorptiometry and gait analysis methods were used to determine structural parameters of the foot and assess their relation to knee joint loading and biomechanical response to wedged insoles in 30 patients with knee osteoarthritis. In multiple linear regression models, foot fat content, height of the medial longitudinal arch and static hind foot angle were not associated with the magnitude of the knee adduction moment (R2  = 0...
April 12, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29651151/the-effect-of-ageing-and-osteoarthritis-on-the-mechanical-properties-of-cartilage-and-bone-in-the-human-knee-joint
#3
Abby E Peters, Riaz Akhtar, Eithne J Comerford, Karl T Bates
Osteoarthritis is traditionally associated with cartilage degeneration although is now widely accepted as a whole-joint disease affecting the entire osteochondral unit; however site-specific cartilage and bone material properties during healthy ageing and disease are absent limiting our understanding. Cadaveric specimens (n = 12; 31-88 years) with grades 0-4 osteoarthritis, were dissected and spatially correlated cartilage, subchondral and trabecular bone samples (n = 8 per cadaver) were harvested from femoral and tibial localities...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29611879/changes-in-the-total-knee-joint-moment-in-patients-with-medial-compartment-knee-osteoarthritis-over-five-years
#4
Jessica L Asay, Jennifer C Erhart-Hledik, Thomas P Andriacchi
Progression of medial compartment knee osteoarthritis (OA) has been associated with repetitive mechanical loading during walking, often characterized by the peak knee adduction (KAM) and knee flexion moments (KFM). However, the relative contributions of these components to the knee total joint moment (TJM) can change as the disease progresses since KAM and KFM are influenced by different factors that change over time. This study tested the hypothesis that the relative contributions of KAM, KFM, and the rotational moment (KRM) to the TJM change over time in subjects with medial compartment knee OA...
April 3, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29610999/quantifying-the-effects-of-different-treadmill-training-speeds-and-durations-on-the-health-of-rat-knee-joints
#5
Jaqueline Lourdes Rios, Kevin Rudi Boldt, James William Mather, Ruth Anne Seerattan, David Arthur Hart, Walter Herzog
BACKGROUND: Walking and running provide cyclical loading to the knee which is thought essential for joint health within a physiological window. However, exercising outside the physiological window, e.g. excessive cyclical loading, may produce loading conditions that could be detrimental to joint health and lead to injury and, ultimately, osteoarthritis. The purpose of this study was to assess the effects of a stepwise increase in speed and duration of treadmill training on knee joint integrity and to identify the potential threshold for joint damage...
April 2, 2018: Sports Medicine—Open
https://www.readbyqxmd.com/read/29595285/-nutraceuticals-in-therapy-of-knee-osteoarthritis-orthopaedic-view
#6
Jiří Gallo
Knee osteoarthritis is one of the most frequent diagnoses of load-carrying joints encountered in orthopaedic surgeons offices. Depending on the clinical stage, the therapy starts with conservative treatment. Corrective osteotomy is indicated in younger patients without an extensive and serious impairment. Implantation of TKR (total knee replacement) is usually indicated in more advanced stages. One of the pillars of conservative therapy is analgesics and non-steroidal antirheumatic drugs. A specific group consists of perorally administered drugs for suppression of symptoms or even deceleration of knee osteoarthrosis...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29575090/gait-mechanics-and-tibiofemoral-loading-in-men-of-the-acl-sports-randomized-control-trial
#7
Jacob J Capin, Ashutosh Khandha, Ryan Zarzycki, Amelia J H Arundale, Melissa L Ziegler, Kurt Manal, Thomas S Buchanan, Lynn Snyder-Mackler
The risk for post-traumatic osteoarthritis is elevated after anterior cruciate ligament reconstruction (ACLR), and may be especially high among individuals with aberrant walking mechanics, such as medial tibiofemoral joint underloading 6 months postoperatively. Rehabilitation training programs have been proposed as one strategy to address aberrant gait mechanics. We developed the anterior cruciate ligament specialized post-operative return-to-sports (ACL-SPORTS) randomized control trial to test the effect of 10 post-operative training sessions consisting of strength, agility, plyometric, and secondary prevention exercises (SAPP) or SAPP plus perturbation (SAPP + PERT) training on gait mechanics after ACLR...
March 25, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29572481/tibial-osteotomy-as-a-mechanical-model-of-primary-osteoarthritis-in-rats
#8
David Britzman, Ibidumo Igah, Theofano Eftaxiopoulou, Warren Macdonald, Anthony M J Bull
This study has presented the first purely biomechanical surgical model of osteoarthritis (OA) in rats, which could be more representative of the human primary disease than intra-articular techniques published previously. A surgical tibial osteotomy (TO) was used to induce degenerative cartilage changes in the medial knee of Sprague-Dawley rats. The presence of osteoarthritic changes in the medial knee compartment of the operated animals was evaluated histologically and through analysis of serum carboxy-terminal telepeptides of type II collagen (CTX-II)...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29564448/intra-articular-tsg-6-delivery-from-heparin-based-microparticles-reduces-cartilage-damage-in-a-rat-model-of-osteoarthritis
#9
Liane E Tellier, Elda A Treviño, Alexandra L Brimeyer, David S Reece, Nick J Willett, Robert E Guldberg, Johnna S Temenoff
As a potential treatment for osteoarthritis (OA), we have developed injectable and hydrolytically degradable heparin-based biomaterials with tunable sulfation for the intra-articular delivery of tumor necrosis factor-alpha stimulated gene-6 (TSG-6), a protein known to inhibit plasmin which may degrade extracellular matrix within OA joints. We first assessed the effect of heparin sulfation on TSG-6 anti-plasmin activity and found that while fully sulfated (Hep) and heparin desulfated at only the N position (Hep-N) significantly enhanced TSG-6 bioactivity in vitro, fully desulfated heparin (Hep-) had no effect, indicating that heparin sulfation plays a significant role in modulating TSG-6 bioactivity...
March 22, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29548817/baseline-varus-deformity-is-associated-with-increased-joint-loading-and-pain-of-non-operated-knee-two-years-after-unilateral-total-knee-arthroplasty
#10
Du Hyun Ro, Hyuk-Soo Han, Seong Hwan Kim, Yoon-Ho Kwak, Jae-Young Park, Myung Chul Lee
BACKGROUND: The goals of this study were (1) to document the gait pattern of patients with unilateral knee osteoarthritis (OA), (2) to determine the knee adduction moment (KAM) changes in the non-operated knee, and (3) to identify the predictors of change in KAM in the non-operated knee. METHODS: The study recruited 23 patients with advanced unilateral knee OA. The preoperative Kellgren-Lawrence (KL) grade of the non-operated knee was one or two; non-operated knee pain, rated using a numeric rating scale (NRS), was less than three out of 10 points...
March 2018: Knee
https://www.readbyqxmd.com/read/29536559/abnormal-loading-of-the-hip-and-knee-joints-in-unilateral-hip-osteoarthritis-persists-two-years-after-total-hip-replacement
#11
Felix Stief, André Schmidt, Stefan van Drongelen, Katharina Lenarz, Dara Froemel, Timur Tarhan, Frederick Lutz, Andrea Meurer
A total hip replacement (THR) is a common and routine procedure to reduce pain and restore normal activity. Gait analysis can provide insights into functional characteristics and dynamic joint loading situation not identifiable by clinical examination or static radiographic measures. The present prospective longitudinal study tested whether 2 years after surgery a THR would restore dynamic loading of the knee and hip joints in the frontal plane to normal. Instrumented gait analysis was performed shortly before surgery and approximately 2 years after THR on 15 unilateral hip osteoarthritis (OA) patients...
March 14, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29473665/lower-limb-muscle-function-during-gait-in-varus-mal-aligned-osteoarthritis-patients
#12
Prasanna Sritharan, Yi-Chung Lin, Sara E Richardson, Kay M Crossley, Trevor B Birmingham, Marcus G Pandy
This study quantified the contributions by muscular, gravitational and inertial forces to the ground reaction force (GRF) and external knee adduction moment (EKAM) for knee osteoarthritis (OA) patients and controls walking at similar speeds. Gait data for 39 varus mal-aligned medial knee OA patients and 15 controls were input into musculoskeletal models to calculate the contributions of individual muscles and gravity to the fore-aft (progression), vertical (support), and mediolateral (balance) GRF, and the EKAM...
February 23, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29464336/current-concepts-in-joint-pain-in-knee-osteoarthritis
#13
REVIEW
K Mills, M Hübscher, H O'Leary, N Moloney
Joint pain attributable to osteoarthritis (OA) is complex and influenced by a myriad of factors beyond local joint pathology. Current practice continues to predominantly adopt a biomedical approach to OA despite emerging evidence of the importance of a more holistic approach. This paper will summarise evidence for the presence of multidimensional pain profiles in knee joint pain and the presence of subgroups characterized by systemic features such as psychological distress, high comorbidity load or sensitisation of the nervous system...
February 20, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29457429/-stiletto-needle-and-needle-knife-for-influence-of-gravity-index-in-treating-knee-osteoarthritis
#14
Li-Jun Gu, Bin Zhang, Wen-Hua Li, Yan Tang, Fu-Hui Dong
OBJECTIVE: To explore stiletto needle and needle-knife for influence of double sufficient weight in treating knee osteoarthritis patients. METHODS: One hundred and thirteen early and medium term knee osteoarthritis patients were randomly divided into three groups, including stiletto needle group(38 cases), needle-knife group (38 cases) and voltaren group (37 cases). In stiletto needle group, there were 13 males and 25 females with an average of(55.87±7.72) years old, treated by stiletto needle once a week, and 2 weeks were a course; there were 11 males and 27 females in needle-knife group with an average of(57...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29453795/inflammatory-and-degenerative-phases-resulting-from-anterior-cruciate-rupture-in-a-non-invasive-murine-model-of-post-traumatic-osteoarthritis
#15
Sophie Jane Gilbert, Cleo Selina Bonnet, Paulina Stadnik, Victor Colin Duance, Deborah JaneMason, Emma Jane Blain
Joint injury is the predominant risk factor for post-traumatic osteoarthritis development (PTOA). Several non-invasive mouse models mimicking human PTOA investigate molecular mechanisms of disease development; none have characterised the inflammatory response to this acute traumatic injury. Our aim was to characterise the early inflammatory phase and later degenerative component in our in vivo non-invasive murine model of PTOA induced by anterior cruciate ligament (ACL) rupture. Right knees of 12-week-old C57Bl6 mice were placed in flexion at a 30° offset position and subjected to a single compressive load (12N, 1...
February 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29428675/a-human-osteoarthritis-osteochondral-organ-culture-model-for-cartilage-tissue-engineering
#16
P Yeung, W Zhang, X N Wang, C H Yan, B P Chan
RATIONALE: In vitro human osteoarthritis (OA)-mimicking models enabling pathophysiological studies and evaluation of emerging therapies such as cartilage tissue engineering are of great importance. OBJECTIVE: We describe the development and characterization of a human OA osteochondral organ culture. We also apply this model for evaluation of the phenotype maintenance of a human MSC derived engineered cartilage, as an example of emerging therapeutics, under long term exposure to the OA-mimicking environment...
February 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29421838/knee-pain-and-the-use-of-various-types-of-footwear-a-review
#17
Morad Chugthai, Jared M Newman, Samuel Akil, Anton Khlopas, Assem A Sultan, Nipun Sodhi, Anil Bhave, Steven F Harwin, Michael A Mont
Knee pain is a highly prevalent condition in the United States with multiple etiologies, with two of the most common sources being osteoarthritis (OA) and patellofemoral pain (PFP). These conditions can lead to reduced physical function and a poor quality of life. Various modalities have been used to decrease the amount of knee pain that individuals' experience; however, they are not always successful and can be expensive. Several studies have reported on specialized footwear for symptomatic alleviation of conditions that affect the knee, this is because it has been theorized that certain footwear can alter the forces placed by muscles on lower-extremity joints, and can potentially alleviate pain by reducing the load placed on the joint...
February 8, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29421350/long-term-evaluation-of-osteoarthritis-sheep-knee-treated-with-tgf-%C3%AE-3-and-bmp-6-induced-multipotent-stem-cells
#18
C C Ude, B S Shamsul, M H Ng, H C Chen, Htwe Ohnmar, S N Amaramalar, A R Rizal, A Johan, M Y Norhamdan, M Azizi, B S Aminuddin, B H I Ruszymah
BACKGROUND: Hyaline articular cartilage, which protects the bones of diarthrodial joints from forces associated with load bearing, frictions, and impacts has very limited capacities for self-repair. Over the years, the trend of treatments has shifted to regenerations and researchers have been on the quest for a lasting regeneration. We evaluated the treatment of osteoarthritis by chondrogenically induced ADSCs and BMSCs for a long time functional recovery. METHODS: Osteoarthritis was induced at the right knee of sheep by complete resection of ACL and medial meniscus...
January 29, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29392383/intramedullary-nailing-in-opening-wedge-high-tibial-osteotomy-in-vitro-test-for-validation-of-a-method-of-fixation
#19
Rene Burchard, Denise Katerla, Marina Hammer, Anke Pahlkötter, Christian Soost, Gerhard Dietrich, Arne Ohrndorf, Wolfgang Richter, Markus Lengsfeld, Hans-Jürgen Christ, Jan Adriaan Graw, Claus-Peter Fritzen
PURPOSE: Opening wedge high tibial osteotomy (HTO) as a treatment in unicompartimental osteoarthritis of the knee can significantly relieve pain and prevent or at least delay an early joint replacement. The fixation of the osteotomy has undergone development and refinements during the last years. The angle-stable plate fixator is currently one of the most commonly used plates in HTOs. The angular stable fixation between screws and the plate offers a high primary stability to retain the correction with early weight-bearing protocols...
February 1, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29382604/relationships-between-in-vivo-dynamic-knee-joint-loading-static-alignment-and-tibial-subchondral-bone-microarchitecture-in-end-stage-knee-osteoarthritis
#20
Bryant C Roberts, Lucian B Solomon, Graham Mercer, Karen J Reynolds, Dominic Thewlis, Egon Perilli
OBJECTIVE: To study, in end-stage knee osteoarthritis (OA) patients, relationships between indices of in vivo dynamic knee joint loads obtained pre-operatively using gait analysis, static knee alignment, and the subchondral trabecular bone (STB) microarchitecture of their excised tibial plateau quantified with 3D micro-CT. DESIGN: Twenty-five knee OA patients scheduled for total knee arthroplasty underwent pre-operative gait analysis. Mechanical axis deviation (MAD) was determined radiographically...
January 27, 2018: Osteoarthritis and Cartilage
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