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Knee joint loading in knee osteoarthritis

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https://www.readbyqxmd.com/read/29222607/static-and-fatigue-strength-of-a-novel-anatomically-contoured-implant-compared-to-five-current-open-wedge-high-tibial-osteotomy-plates
#1
Arnaud Diffo Kaze, Stefan Maas, James Belsey, Alexander Hoffmann, Dietrich Pape
BACKGROUND: The purpose of the present study was to compare the mechanical static and fatigue strength of the size 2 osteotomy plate "Activmotion" with the following five other common implants for the treatment of medial knee joint osteoarthritis: the TomoFix small stature, the TomoFix standard, the Contour Lock, the iBalance and the second generation PEEKPower. METHODS: Six fourth-generation tibial bone composites underwent a medial open-wedge high tibial osteotomy (HTO), according to standard techniques, using size 2 Activmotion osteotomy plates...
December 8, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29221427/validity-of-the-dutch-modified-paindetect-questionnaire-for-patients-with-hip-or-knee-osteoarthritis
#2
Wietske Rienstra, Tim Blikman, Baukje Dijkstra, Jos van Raay, Geranda Slager, Sjoerd Bulstra, Martin Stevens, Inge van den Akker-Scheek
BACKGROUND: The modified painDETECT questionnaire (PDQ) is a self-reported questionnaire to discriminate between nociceptive and neuropathic-like pain in patients with knee/hip osteoarthritis (OA). This study aims to assess the structural and construct validity of this questionnaire. METHODS: Confirmatory factor analysis and hypothesis-testing was used. For 168 patients, predefined hypotheses were formulated on the correlation between the modified painDETECT and several other questionnaires, and in a subsample of 46 with pain pressure thresholds (PPTs)...
December 8, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29198047/medial-meniscus-grafting-restores-normal-tibiofemoral-contact-pressures
#3
John Nyland, Kirk Campbell, Alaa Kalloub, Eric J Strauss, Katrina Kuban, David N M Caborn
BACKGROUND: Tissue excision in the setting of a meniscal tear has been shown to dramatically increase peak contact stresses in the affected tibiofemoral joint compartment, leading to the development of degenerative changes and osteoarthritis. PURPOSE/HYPOTHESIS: The current in vitro study utilized a porcine model to evaluate the effectiveness of segmental medial meniscal grafting following partial meniscectomy. The study hypothesis was that the procedure would normalize medial tibofemoral joint compartment pressure magnitudes, areas, and locations relative to an intact meniscus...
December 2, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29194431/characteristics-of-plantar-loads-during-walking-in-patients-with-knee-osteoarthritis
#4
Zhiwang Zhang, Lin Wang, Kaijun Hu, Yu Liu
BACKGROUND Knee osteoarthritis (KOA) is a common disease that can change the load on lower limbs during walking. Plantar loads in patients with KOA may provide a basis for clinical decisions regarding footwear and foot orthoses. This study aimed to compare plantar loads in females with and without KOA during gait. MATERIAL AND METHODS Plantar pressure during walking was recorded in 23 females with KOA and 23 females without KOA. Maximum force (MF), contact area (CA), and peak pressure (PP) were measured at 7 different regions underneath the foot, named heel (M1), midfoot (M2), first metatarsophalangeal joint (MPJ) (M3), second MPJ (M4), third to fifth MPJ (M5), hallux (M6), and lesser toes (M7)...
December 1, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29192542/the-effects-of-a-simulated-occupational-kneeling-exposure-on-squat-mechanics-and-knee-joint-load-during-gait
#5
Liana Michele Tennant, Helen Christina Chong, Stacey Marie Acker
Occupational kneeling is associated with an increased risk for tibiofemoral knee osteoarthritis. Forces on the knee in the kneeling posture, as well as the greater incidence of meniscus tears among workers likely contribute to the increased risk. We hypothesize that an additional mechanism may contribute - altered neuromuscular control due to prolonged high knee flexion. Forty participants (20 male, 20 female) completed an evaluation of gait and squatting before, immediately following, and 30 minutes following a 30-minute simulated occupational kneeling exposure...
December 1, 2017: Ergonomics
https://www.readbyqxmd.com/read/29191221/increased-synovial-lipodystrophy-induced-by-high-fat-diet-aggravates-synovitis-in-experimental-osteoarthritis
#6
Ane Larrañaga-Vera, Ana Lamuedra, Sandra Pérez-Baos, Ivan Prieto-Potin, Leticia Peña, Gabriel Herrero-Beaumont, Raquel Largo
BACKGROUND: Metabolic syndrome (MetS) may be associated with knee osteoarthritis (OA), but the association between the individual components and OA are not well-understood. We aimed to study the effect of hypercholesterolemia on synovial inflammation in knee OA. METHODS: OA was surgically induced in rabbits fed with standard diet (OA group, n = 10) or in rabbits fed with high fat diet (OA-HFD, n = 10). Healthy rabbits receiving standard diet (Control, n = 10) or fed with HFD (HFD, n = 6) were also monitored...
December 1, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29185004/poor-knee-function-after-acl-reconstruction-is-associated-with-attenuated-landing-force-and-knee-flexion-moment-during-running
#7
Luke G Perraton, Michelle Hall, Ross A Clark, Kay M Crossley, Yong-Hao Pua, Tim S Whitehead, Hayden G Morris, Adam G Culvenor, Adam L Bryant
PURPOSE: Poor knee function after anterior cruciate ligament reconstruction (ACLR) may increase the risk of future knee symptoms and knee osteoarthritis via abnormal knee joint loading patterns, particularly during high-impact activity. This study aimed to assess the relationship between poor self-reported or clinically measured knee function and knee moments/vertical ground reaction force (vGRF) in individuals following ACLR. METHODS: 61 participants (mean 16.5 ± 3 months following ACLR, 23 women) completed a patient-reported knee function questionnaire and three hop tests (% of uninvolved limb)...
November 28, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29174844/neuromuscular-adaptations-in-older-males-and-females-with-knee-osteoarthritis-during-weight-bearing-force-control
#8
Heather J Bigham, Teresa E Flaxman, Andrew J J Smith, Daniel L Benoit
BACKGROUND: Females exhibit significantly greater incidence, prevalence, and severity of osteoarthritis (OA) compared to males. Despite known biological, morphological, and functional differences between males and females, there has been little sex-related investigation into sex-specific biomechanical and neuromuscular responses to OA. OBJECTIVE: To identify sex-related differences in OA-affected adults and within-sex differences between healthy and OA-affected adults' muscular activation patterns during lower limb loading...
November 22, 2017: Knee
https://www.readbyqxmd.com/read/29154178/the-effect-of-wedge-and-tibial-slope-angles-on-knee-contact-pressure-and-kinematics-following-medial-opening-wedge-high-tibial-osteotomy
#9
Marianne S Black, Agnes G d'Entremont, Robert G McCormack, Gregory Hansen, Derek Carr, David R Wilson
BACKGROUND: High tibial osteotomy is a surgical procedure to treat medial compartment osteoarthritis in varus knees. The reported success rates of the procedure are inconsistent, which may be due to sagittal plane alignment of the osteotomy. The objective of this study was to determine the effect of changing tibial slope, for a range of tibial wedge angles in high tibial osteotomy, on knee joint contact pressure location and kinematics during continuous loaded flexion/extension. METHODS: Seven cadaveric knee specimens were cycled through flexion and extension in an Oxford knee-loading rig...
November 2, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29150953/new-algorithm-for-simulation-of-proteoglycan-loss-and-collagen-degeneration-in-the-knee-joint-data-from-the-osteoarthritis-initiative
#10
Mika E Mononen, Petri Tanska, Hanna Isaksson, Rami K Korhonen
Osteoarthritis is a harmful joint disease but prediction of disease progression is problematic. Currently, there is only one modeling framework which can be applied to predict the progression of knee osteoarthritis but it only considers degenerative changes in the collagen fibril network. Here, we have developed the framework further by considering all of the major tissue changes (proteoglycan content, fluid flow and collagen fibril network) occurring in osteoarthritis. While excessive levels of tissue stresses controlled degeneration of the collagen fibril network, excessive levels of tissue strains controlled the decrease in proteoglycan content and the increase in permeability...
November 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29129608/no-exacerbation-of-knee-joint-pain-and-effusion-following-preoperative-progressive-resistance-training-in-patients-scheduled-for-total-knee-arthroplasty-secondary-analyses-from-a-randomized-controlled-trial
#11
Birgit Skoffer, Ulrik Dalgas, Thomas Maribo, Kjeld Søballe, Inger Mechlenburg
BACKGROUND: Preoperative progressive resistance training (PRT) is controversial in patients scheduled for total knee arthroplasty (TKA), because of the concern that it may exacerbate knee joint pain and effusion. OBJECTIVE: To examine if preoperative PRT initiated 5 weeks prior to TKA would 1) exacerbate pain and knee effusion, 2) allow a progressively increased training load throughout the training period that would subsequently increase muscle strength. DESIGN: Secondary analyses from a randomized controlled trial...
November 9, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29128508/relative-and-absolute-test-retest-reliabilities-of-biomechanical-risk-factors-for-knee-osteoarthritis-progression-benchmarks-for-meaningful-change
#12
N M Brisson, P W Stratford, M R Maly
OBJECTIVE: Biomechanical factors are important treatment targets in knee osteoarthritis. The knee adduction (KAM) and flexion (KFM) moments, quadriceps strength and power, load frequency, and body mass index (BMI) all have the potential to affect knee articular cartilage integrity by modulating forces across the joint. To identify clinically meaningful change, however, these measurements must be reliable and sensitive to change. This study estimated relative and absolute test-retest reliabilities over long periods of biomechanical risk factors for knee osteoarthritis progression...
November 9, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29127754/-osteoarthritis-as-part-of-metabolic-syndrome
#13
Karel Pavelka
Osteoarthritis (OA) is the most frequent joint disease, whereas etiopathogenesis of OA is not entirely clarified. It is a heterogeneous disorder and genetic as well as biomechanical, endocrine and inflammatory effects may be involved in its origin. The author examines the problems concerning relationships between the metabolic syndrome and OA, and states that the prevalence of metabolic syndrome in patients with OA is higher than in those without OA (59 % vs 23 %). It remains problematic that one of the main components of metabolic syndrome is obesity which in itself is a risk factor for arthrosis development in the weight-bearing joints, not for OA in the hands...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29117248/medial-knee-loading-is-altered-in-subjects-with-early-osteoarthritis-during-gait-but-not-during-step-up-and-over-task
#14
Susana Meireles, Mariska Wesseling, Colin R Smith, Darryl G Thelen, Sabine Verschueren, Ilse Jonkers
This study evaluates knee joint loading during gait and step-up-and-over tasks in control subjects, subjects with early knee OA and those with established knee OA. Thirty-seven subjects with varying degrees of medial compartment knee OA severity (eighteen with early OA and sixteen with established OA), and nineteen healthy controls performed gait and step-up-and-over tasks. Knee joint moments, contact forces (KCF), the magnitude of contact pressures and center of pressure (CoP) location were analyzed for the three groups for both activities using a multi-body knee model with articular cartilage contact, 14 ligaments, and six degrees of freedom tibiofemoral and patellofemoral joints...
2017: PloS One
https://www.readbyqxmd.com/read/29060194/effects-of-counteracting-external-valgus-moment-on-lateral-tibial-cartilage-contact-conditions-and-tibial-rotation
#15
Duraisamy Shriram, Rizuwana Parween, Yee Han Dave Lee, Karupppasamy Subburaj
Knee osteoarthritis that prevalently occurs at the medial compartment is a progressive chronic disorder affecting the articular cartilage of the knee joint, and lead to loss of joint functionality. Valgus braces have been used as a treatment procedure to unload the medial compartment for patients with medial osteoarthritis. Valgus braces through the application of counteracting external valgus moment shift the load from medial compartment towards the lateral compartment. Previous biomechanical studies focused only on the changes in varus moments before and after wearing the brace...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29028621/combining-valgus-knee-brace-and-lateral-foot-wedges-reduces-external-forces-and-moments-in-osteoarthritis-patients
#16
Amir Ali Jafarnezhadgero, Anderson S Oliveira, Seyed Hamed Mousavi, Morteza Madadi-Shad
Osteoarthritis progression can be related to the external knee adduction and flexion moments during walking. Lateral foot wedges and knee braces have been used as treatment for osteoarthritis, but little is known about their influence on knee joint moments generated in the sagittal and frontal planes. Therefore, the aim of the present study was determine the effects of the isolated and combined use of valgus knee brace and lateral wedge foot orthotic on peak forces and moments during gait in knee osteoarthritis patients...
October 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29024567/subchondral-bone-plate-sclerosis-during-late-osteoarthritis-is-caused-by-loading-induced-reduction-in-sclerostin
#17
Haoruo Jia, Xiaoyuan Ma, Yulong Wei, Wei Tong, Robert J Tower, Abhishek Chandra, Luqiang Wang, Zeyang Sun, Zhaochun Yang, Farid Badar, Kairui Zhang, Wei-Ju Tseng, Ina Kramer, Michaela Kneissel, Yang Xia, X Sherry Liu, James H-C Wang, Lin Han, Motomi Enomoto-Iwamoto, Ling Qin
OBJECTIVE: To establish an unbiased 3D approach that quantifies subchondral bone plate (SBP) changes in mouse joints and to investigate the mechanism that mediates SBP sclerosis at a late stage of osteoarthritis (OA). DESIGN: A new microCT protocol was developed to characterize the entire SBP thickness in the distal femur of a mouse knee. Four mouse models with severe joint OA were generated: cartilage-specific Egfr knockout (CKO) mice at 2 months after surgical destabilization of the medial meniscus (DMM), aged Egfr CKO mice, wild-type (WT) mice at 10 months after DMM, and WT mice after DMM plus hemisectomy of the meniscus (DMMH) surgery...
October 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28989290/feasibility-of-the-atlas-unicompartmental-knee-system-load-absorber-in-improving-pain-relief-and-function-in-patients-needing-unloading-of-the-medial-compartment-of-the-knee-1-year-follow-up-of-a-prospective-multicenter-single-arm-pilot-study-phantom-high-flex
#18
Konrad Slynarski, Jacek Walawski, Robert Smigielski, Willem van der Merwe
In young patients with medial knee osteoarthritis (OA), surgical intervention may not be desirable due to preferences to avoid bone cutting procedures, return to high activity levels, and prolong implant survival. The Atlas Knee System was designed to fill the gap between ineffective conservative treatments and invasive surgery. This single-arm study included 26 patients, aged 25 to 65 years, who completed 12 months of follow-up. All dimensions of the Knee injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Knee Society Score significantly improved from baseline to 12 months...
2017: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28957738/standard-versus-physiologic-bone-preparation-in-total-knee-arthroplasty-and-the-effect-on-joint-space-opening
#19
Timothy A Burkhart, Benjamin V Herman, Kevin Perry, Pieter-Jan Vandekerckhove, James Howard, Brent Lanting
BACKGROUND: Total knee arthroplasty is an effective treatment for osteoarthritis. Restoration of physiologic varus alignment may restore the native soft tissue tension and improve outcomes. METHODS: Six paired fresh-frozen knee specimens were used to perform total knee arthroplastys. The left and right sides of were randomly assigned to have either a physiologic alignment cut or a standard of care neutral alignment bony cut prior to the implantation. Loads of 100 and 200N were applied at 0, 30, 60, and 90° of flexion and the magnitude of the medial and lateral compartment distraction was measured...
September 18, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28926635/a-comparison-of-running-kinetics-in-children-with-and-without-genu-varus-a-cross-sectional-study
#20
Amir Ali Jafarnezhadgero, Morteza Madadi Shad, Mahdi Majlesi, Urs Granacher
INTRODUCTION: Varus knee alignment has been identified as a risk factor for the progression of medial knee osteoarthritis. However, the underlying mechanisms have not been elucidated yet in children. Thus, the aims of the present study were to examine differences in ground reaction forces, loading rate, impulses, and free moment values during running in children with and without genu varus. METHODS: Thirty-six boys aged 9-14 volunteered to participate in this study...
2017: PloS One
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