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Knee joint loading in knee osteoarthritis

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https://www.readbyqxmd.com/read/29028621/combining-valgus-knee-brace-and-lateral-foot-wedges-reduces-external-forces-and-moments-in-osteoarthritis-patients
#1
Amir Ali Jafarnezhadgero, Anderson S Oliveira, Seyed Hamed Mousavi, Morteza Madadi-Shad
Osteoarthritis progression can be related to the external knee adduction and flexion moments during walking. Lateral foot wedges and knee braces have been used as treatment for osteoarthritis, but little is known about their influence on knee joint moments generated in the sagittal and frontal planes. Therefore, the aim of the present study was determine the effects of the isolated and combined use of valgus knee brace and lateral wedge foot orthotic on peak forces and moments during gait in knee osteoarthritis patients...
October 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29024567/subchondral-bone-plate-sclerosis-during-late-osteoarthritis-is-caused-by-loading-induced-reduction-in-sclerostin
#2
Haoruo Jia, Xiaoyuan Ma, Yulong Wei, Wei Tong, Robert J Tower, Abhishek Chandra, Luqiang Wang, Zeyang Sun, Zhaochun Yang, Farid Badar, Kairui Zhang, Wei-Ju Tseng, Ina Kramer, Michaela Kneissel, Yang Xia, X Sherry Liu, James H-C Wang, Lin Han, Motomi Enomoto-Iwamoto, Ling Qin
OBJECTIVE: To establish an unbiased 3D approach that quantifies subchondral bone plate (SBP) changes in mouse joints and to investigate the mechanism that mediates SBP sclerosis at a late stage of osteoarthritis (OA). DESIGN: A new microCT protocol was developed to characterize the entire SBP thickness in the distal femur of a mouse knee. Four mouse models with severe joint OA were generated: cartilage-specific Egfr knockout (CKO) mice at 2 months after surgical destabilization of the medial meniscus (DMM), aged Egfr CKO mice, wild-type (WT) mice at 10 months after DMM, and WT mice after DMM plus hemisectomy of the meniscus (DMMH) surgery...
October 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28989290/feasibility-of-the-atlas-unicompartmental-knee-system-load-absorber-in-improving-pain-relief-and-function-in-patients-needing-unloading-of-the-medial-compartment-of-the-knee-1-year-follow-up-of-a-prospective-multicenter-single-arm-pilot-study-phantom-high-flex
#3
Konrad Slynarski, Jacek Walawski, Robert Smigielski, Willem van der Merwe
In young patients with medial knee osteoarthritis (OA), surgical intervention may not be desirable due to preferences to avoid bone cutting procedures, return to high activity levels, and prolong implant survival. The Atlas Knee System was designed to fill the gap between ineffective conservative treatments and invasive surgery. This single-arm study included 26 patients, aged 25 to 65 years, who completed 12 months of follow-up. All dimensions of the Knee injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Knee Society Score significantly improved from baseline to 12 months...
2017: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28957738/standard-versus-physiologic-bone-preparation-in-total-knee-arthroplasty-and-the-effect-on-joint-space-opening
#4
Timothy A Burkhart, Benjamin V Herman, Kevin Perry, Pieter-Jan Vandekerckhove, James Howard, Brent Lanting
BACKGROUND: Total knee arthroplasty is an effective treatment for osteoarthritis. Restoration of physiologic varus alignment may restore the native soft tissue tension and improve outcomes. METHODS: Six paired fresh-frozen knee specimens were used to perform total knee arthroplastys. The left and right sides of were randomly assigned to have either a physiologic alignment cut or a standard of care neutral alignment bony cut prior to the implantation. Loads of 100 and 200N were applied at 0, 30, 60, and 90° of flexion and the magnitude of the medial and lateral compartment distraction was measured...
September 18, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28926635/a-comparison-of-running-kinetics-in-children-with-and-without-genu-varus-a-cross-sectional-study
#5
Amir Ali Jafarnezhadgero, Morteza Madadi Shad, Mahdi Majlesi, Urs Granacher
INTRODUCTION: Varus knee alignment has been identified as a risk factor for the progression of medial knee osteoarthritis. However, the underlying mechanisms have not been elucidated yet in children. Thus, the aims of the present study were to examine differences in ground reaction forces, loading rate, impulses, and free moment values during running in children with and without genu varus. METHODS: Thirty-six boys aged 9-14 volunteered to participate in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28903010/effect-of-loading-on-in-vivo-tibiofemoral-and-patellofemoral-kinematics-of-healthy-and-acl-reconstructed-knees
#6
Jarred M Kaiser, Michael F Vignos, Richard Kijowski, Geoffrey Baer, Darryl G Thelen
BACKGROUND: Although knees that have undergone anterior cruciate ligament reconstruction (ACLR) often exhibit normal laxity on clinical examination, abnormal kinematic patterns have been observed when the joint is dynamically loaded during whole body activity. This study investigated whether abnormal knee kinematics arise with loading under isolated dynamic movements. HYPOTHESIS: Tibiofemoral and patellofemoral kinematics of ACLR knees will be similar to those of the contralateral uninjured control knee during passive flexion-extension, with bilateral differences emerging when an inertial load is applied...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28888109/biomechanical-compensations-of-the-trunk-and-lower-extremities-during-stepping-tasks-after-unilateral-transtibial-amputation
#7
Amanda M Murray, Brecca M Gaffney, Bradley S Davidson, Cory L Christiansen
BACKGROUND: Lower extremity movement compensations following transtibial amputation are well-documented and are likely influenced by trunk posture and movement. However, the biomechanical compensations of the trunk and lower extremities, especially during high-demand tasks such as step ascent and descent, remain unclear. METHODS: Kinematic and kinetic data were collected during step ascent and descent tasks for three groups of individuals: diabetic/transtibial amputation, diabetic, and healthy...
August 30, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28875154/structural-and-anatomic-restoration-of-the-anterior-cruciate-ligament-is-associated-with-less-cartilage-damage-1-year-after-surgery-healing-ligament-properties-affect-cartilage-damage
#8
Ata M Kiapour, Braden C Fleming, Martha M Murray
BACKGROUND: Abnormal joint motion has been linked to joint arthrosis after anterior cruciate ligament (ACL) reconstruction. However, the relationships between the graft properties (ie, structural and anatomic) and extent of posttraumatic osteoarthritis are not well defined. HYPOTHESES: (1) The structural (tensile) and anatomic (area and alignment) properties of the reconstructed graft or repaired ACL correlate with the total cartilage lesion area 1 year after ACL surgery, and (2) side-to-side differences in anterior-posterior (AP) knee laxity correlate with the total cartilage lesion area 1 year postoperatively...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28865300/technical-feasibility-of-personalized-articulating-knee-joint-distraction-for-treatment-of-tibiofemoral-osteoarthritis
#9
T Struik, J E N Jaspers, N J Besselink, P M van Roermund, S Plomp, M J Rudert, F P J G Lafeber, S C Mastbergen
BACKGROUND: Knee osteoarthritis is a highly prevalent degenerative joint disorder characterized by joint tissue damage and pain. Knee joint distraction has been introduced as a joint preserving surgical procedure to postpone knee arthroplasty. An often used standard externally fixation device for distraction poses a burden to patients due to the absence of joint flexion during the 6weeks treatment. Therefore, a personalized articulating distraction device was developed. The aim of this study was to test technical feasibility of this device...
August 12, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28835342/loss-of-acl-function-leads-to-alterations-in-tibial-plateau-common-dynamic-contact-stress-profiles
#10
Tony Chen, Hongsheng Wang, Russell Warren, Suzanne Maher
It has been suggested that the repetitive nature of altered joint tissue loading which occurs after anterior cruciate ligament (ACL) rupture can contribute to the development of osteoarthritis (OA). However, changes in dynamic knee joint contact stresses after ACL rupture have not been quantified for activities of daily living. Our objective was to characterize changes in dynamic contact stress profiles that occur across the tibial plateau immediately after ACL transection. By subjecting sensor-augmented cadaveric knees to simulated gait, and analyzing the resulting contact stress profiles using a normalized cross-correlation algorithm, we tested the hypothesis that common changes in dynamic contact stress profiles exist after ACL injury...
August 16, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28822943/sound-side-joint-contact-forces-in-below-knee-amputee-gait-with-an-esar-prosthetic-foot
#11
Mohammad Taghi Karimi, Firooz Salami, Amir Esrafilian, Daniel W W Heitzmann, Merkur Alimusaj, Cornelia Putz, Sebastian I Wolf
The incidence of knee and hip joint osteoarthritis in subjects with below knee amputation (BK) appears significantly higher compared to unimpaired subjects, especially in the intact side. However, it is controversial if constant higher loads on the sound side are one of the major factors for an increased osteoarthritis (OA) incidence in subjects with BK, beside other risk factors, e.g. with respect to metabolism. The aim wasto investigate joint contact forces (JCF) calculated by a musculoskeletal model in the intact side and to compare it with those of unimpaired subjects and to further elucidate in how far increased knee JCF are associated with increased frontal plane knee moments...
August 8, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28811046/effect-of-real-time-biofeedback-on-peak-knee-adduction-moment-in-patients-with-medial-knee-osteoarthritis-is-direct-feedback-effective
#12
Rosie E Richards, Josien C van den Noort, Martin van der Esch, Marjolein J Booij, Jaap Harlaar
BACKGROUND: Gait modifications can reduce the knee adduction moment, a representation of knee loading. Reduced loading may help to slow progression of medial knee osteoarthritis. We aimed to investigate the response of patients with medial knee osteoarthritis to direct feedback on the knee adduction moment as a method for modifying the gait pattern, before and after training with specific gait modifications. METHODS: Forty patients with medial knee osteoarthritis underwent 3D gait analysis on an instrumented-treadmill, while receiving real-time feedback on the peak knee adduction moment...
July 13, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28799491/exercise-programmes-for-osteoarthritis-with-different-localization
#13
Sevdalina Lambova
Therapeutic exercises in osteoarthritis (OA) are therapeutic approach with proven efficacy. On the other hand, the different disease form, the lack of established consensus and system for patient education limit the widespread use of therapeutic exercises in clinical practice. The mechanisms of action of therapeutic exercise in OA include the following components e. g., neuromuscular (improvement of proprioception, muscle strength and joint stability), intra-articular (prevention of cartilage degeneration, antiinflammatory effect, improvement of the quality of the joint fluid), periarticular, general health with reduction of cardiovascular risk and psychological components...
August 10, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28768432/effects-of-surgical-factors-on-cartilage-can-be-detected-using-quantitative-magnetic-resonance-imaging-after-anterior-cruciate-ligament-reconstruction
#14
Keiko Amano, Alan K Li, Valentina Pedoia, Matthew F Koff, Aaron J Krych, Thomas M Link, Hollis Potter, Scott Rodeo, Xiaojuan Li, C Benjamin Ma, Sharmila Majumdar
BACKGROUND: Quantitative magnetic resonance (qMR) can be used to measure macromolecules in tissues and is a potential method of observing early cartilage changes in the development of posttraumatic osteoarthritis. Hypothesis/Purpose: We hypothesized that specific patient and surgical factors affecting cartilage matrix composition after anterior cruciate ligament (ACL) reconstruction (ACLR) can be detected using T1ρ and T2 relaxation times. Our purpose was to demonstrate this ability in a multicenter feasibility study...
April 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28763623/the-effects-of-anterolateral-tenodesis-on-tibiofemoral-contact-pressures-and-kinematics
#15
Eivind Inderhaug, Joanna M Stephen, Hadi El-Daou, Andy Williams, Andrew A Amis
BACKGROUND: Anterolateral tenodeses are increasingly popular in combination with intra-articular anterior cruciate ligament reconstructions. Despite the perception of risk of overconstraint and lateral osteoarthritis, evidence is lacking regarding the effect of graft tensioning on knee kinematics and intra-articular compartmental joint pressures. PURPOSE: To investigate tibiofemoral joint contact pressures and kinematics related to an anterolateral lesion and the effectiveness of a MacIntosh tenodesis in restoring these when varying (1) graft tension and (2) tibial rotation during graft fixation...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28755495/identification-of-good-candidates-for-valgus-bracing-as-a-treatment-for-medial-knee-osteoarthritis
#16
Allison L Clouthier, Elizabeth A Hassan, Scott C E Brandon, Aaron Campbell, Michael J Rainbow, Kevin J Deluzio
Valgus unloader braces are a conservative treatment option for medial compartment knee osteoarthritis that aim to unload the damaged medial compartment through application of an external abduction moment. Patient response to bracing is highly variable, however. While some experience improvements in pain, function, and joint loading, others receive little to no benefit. The objective of this work was to analyze clinical measures and biomechanical characteristics of unbraced walking to identify variables that are associated with the mechanical effectiveness of valgus unloader bracing...
July 29, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28742277/immediate-and-short-term-effects-of-real-time-knee-adduction-moment-feedback-on-the-peak-and-cumulative-knee-load-during-walking
#17
Brennan Jackson, Keith E Gordon, Alison H Chang
The peak external knee adduction moment (pKAM), KAM impulse, and peak knee flexion moment (pKFM) during gait are important loading variables in medial tibiofemoral osteoarthritis. We evaluated the effects of gait modification, using real-time pKAM visual feedback, on pKAM, KAM impulse, and pKFM; and whether participants could maintain the KAM-reducing gait after feedback removal. Eleven healthy individuals performed a series of walking trials on a split-belt instrumented treadmill under four conditions of Baseline, Feedback, No Feedback Early, and No Feedback Late...
July 25, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28658860/muscle-activation-profiles-and-co-activation-of-quadriceps-and-hamstring-muscles-around-knee-joint-in-indian-primary-osteoarthritis-knee-patients
#18
Sanjeev Kumar Sharma, Shiv Lal Yadav, U Singh, Sanjay Wadhwa
INTRODUCTION: Osteoarthritis (OA) of knee is a common joint disease. It is associated with reduced knee joint stability due to impaired quadriceps strength, pain, and an altered joint structure. There is altered muscle activation in knee OA patients, which interferes with normal load distribution around the knee and facilitates disease progression. AIM: Our primary aim was to determine activation patterns of the muscles i.e., quadriceps and hamstrings in knee OA patients during walking...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28642979/-medial-opening-wedge-high-tibial-osteotomy
#19
REVIEW
P Niemeyer, A Stöhr, M Köhne, A Hochrein
OBJECTIVE: Reduction of the load to the medial compartment in patients with medial knee osteoarthritis and varus malalignment. Unloading of the posterolateral complex in varus deformity with complex ligamentous laxity. INDICATIONS: Medial knee osteoarthritis and varus malalignment with largely intact lateral and patellofemoral joint aspect. Complex ligament insufficiency combined with varus deformity. CONTRAINDICATIONS: Substantially impaired range of motion...
August 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28642164/joint-loading-and-proximal-tibia-subchondral-trabecular-bone-microarchitecture-differ-with-walking-gait-patterns-in-end-stage-knee-osteoarthritis
#20
B C Roberts, L B Solomon, G Mercer, K J Reynolds, D Thewlis, E Perilli
OBJECTIVES: To (1) stratify patient subgroups according to their distinct walking gait patterns in end-stage knee osteoarthritis (OA); (2) compare measures of joint loading and proximal tibia subchondral trabecular bone (STB) microarchitecture among these gait subgroups. DESIGN: Twenty-five knee OA patients undergoing total knee arthroplasty (TKA) had pre-operative gait analysis. Following surgery, excised tibial plateaus were micro-CT-scanned and STB microarchitecture analysed in four tibial condylar regions of interest...
June 20, 2017: Osteoarthritis and Cartilage
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