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Knee joint loading in knee osteoarthritis

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https://www.readbyqxmd.com/read/27897156/quantitative-evaluation-of-the-mechanical-risks-caused-by-focal-cartilage-defects-in-the-knee
#1
Mikko S Venäläinen, Mika E Mononen, Jari Salo, Lasse P Räsänen, Jukka S Jurvelin, Juha Töyräs, Tuomas Virén, Rami K Korhonen
Focal cartilage lesions can proceed to severe osteoarthritis or remain unaltered even for years. A method to identify high risk defects would be of utmost importance to guide clinical decision making and to identify the patients that are at the highest risk for the onset and progression of osteoarthritis. Based on cone beam computed tomography arthrography, we present a novel computational model for evaluating changes in local mechanical responses around cartilage defects. Our model, based on data obtained from a human knee in vivo, demonstrated that the most substantial alterations around the defect, as compared to the intact tissue, were observed in minimum principal (compressive) strains and shear strains...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27842586/hyaline-cartilage-calcification-of-the-first-metatarsophalangeal-joint-is-associated-with-osteoarthritis-but-independent-of-age-and-bmi
#2
Jan Hubert, Thelonius Hawellek, Sandra Hischke, Jessica Bertrand, Matthias Krause, Klaus Püschel, Wolfgang Rüther, Andreas Niemeier
BACKGROUND: Hyaline cartilage calcification (CC) is associated with osteoarthritis (OA) in hip and knee joints. The first metatarsophalangeal joint (1(st)MTPJ) is frequently affected by OA, but it is unclear if CC occurs in the 1(st)MTPJ. The aim of the present study was to analyze the prevalence of CC of the 1(st)MTPJ in the general population by high-resolution digital contact radiography (DCR) and to determine its association with histological OA severity, age and body mass index (BMI)...
November 15, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27836707/celecoxib-loaded-pea-microspheres-as-an-auto-regulatory-drug-delivery-system-after-intra-articular-injection
#3
Maarten Janssen, Ufuk Tan Timur, Nina Woike, Tim J M Welting, Guy Draaisma, Marion Gijbels, Lodewijk W van Rhijn, George Mihov, Jens Thies, Pieter J Emans
In this study, we investigated the potential of celecoxib-loaded polyester amide (PEA) microspheres as an auto-regulating drug delivery system for the treatment of pain associated with knee osteoarthritis (OA). Celecoxib release from PEA microspheres and inflammation responsive release of a small molecule from PEA was investigated in vitro. Inflammation responsive release of a small molecule from PEA was observed when PEA was exposed to cell lysates obtained from a neutrophil-like Hl-60 cell line. Following a short initial burst release of ~15% of the total drug load in the first days, celecoxib was slowly released throughout a period of >80days...
November 8, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27836677/the-effect-of-instruction-in-analgesic-use-compared-with-neuromuscular-exercise-on-knee-joint-load-in-patients-with-knee-osteoarthritis-a-randomized-single-blind-controlled-trial
#4
A Holsgaard-Larsen, B Clausen, J Søndergaard, R Christensen, T P Andriacchi, E M Roos
OBJECTIVE: To investigate the effect of a neuro-muscular exercise (NEMEX) therapy program compared with instructions in optimized analgesics and anti-inflammatory drug use (PHARMA), on measures of knee-joint load in people with mild to moderate knee osteoarthritis (OA). We hypothesized that knee joint loading during walking would be reduced by NEMEX and potentially increased by PHARMA. DESIGN: Single-blind, RCT comparing NEMEX therapy twice a week with PHARMA. Participants with mild-to-moderate medial tibiofemoral knee OA were randomly allocated (1:1) to one of two 8-week treatments...
November 9, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27825602/comparison-of-different-material-models-of-articular-cartilage-in-3d-computational-modeling-of-the-knee-data-from-the-osteoarthritis-initiative-oai
#5
Olesya Klets, Mika E Mononen, Petri Tanska, Miika T Nieminen, Rami K Korhonen, Simo Saarakkala
The intricate properties of articular cartilage and the complexity of the loading environment are some of the key challenges in developing models for biomechanical analysis of the knee joint. Fibril-reinforced poroelastic (FRPE) material models have been reported to accurately capture characteristic responses of cartilage during dynamic and static loadings. However, high computational and time costs associated with such advanced models limit applicability of FRPE models when multiple subjects need to be analyzed...
October 25, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27820852/osteoarthritis-in-the-knee-joints-of-g%C3%A3-ttingen-minipigs-after-resection-of-the-anterior-cruciate-ligament-missing-correlation-of-mri-gene-and-protein-expression-with-histological-scoring
#6
Gregor Reisig, Michael Kreinest, Wiltrud Richter, Mechthild Wagner-Ecker, Dietmar Dinter, Ulrike Attenberger, Barbara Schneider-Wald, Stefan Fickert, Markus L Schwarz
INTRODUCTION: The Göttingen Minipig (GM) is used as large animal model in articular cartilage research. The aim of the study was to introduce osteoarthritis (OA) in the GM by resecting the anterior cruciate ligament (ACLR) according to Pond and Nuki, verified by histological and magnetic resonance imaging (MRI) scoring as well as analysis of gene and protein expression. MATERIALS AND METHODS: The eight included skeletally mature female GM were assessed after ACLR in the left and a sham operation in the right knee, which served as control...
2016: PloS One
https://www.readbyqxmd.com/read/27809923/functional-electrical-stimulation-of-gluteus-medius-reduces-the-medial-joint-reaction-force-of-the-knee-during-level-walking
#7
Lance Rane, Anthony Michael James Bull
BACKGROUND: By altering muscular activation patterns, internal forces acting on the human body during dynamic activity may be manipulated. The magnitude of one of these forces, the medial knee joint reaction force (JRF), is associated with disease progression in patients with early osteoarthritis (OA), suggesting utility in its targeted reduction. Increased activation of gluteus medius has been suggested as a means to achieve this. METHODS: Motion capture equipment and force plate transducers were used to obtain kinematic and kinetic data for 15 healthy subjects during level walking, with and without the application of functional electrical stimulation (FES) to gluteus medius...
November 3, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27803343/knee-pain-predicts-subsequent-shoulder-pain-and-the-association-is-mediated-by-leg-weakness-longitudinal-observational-data-from-the-osteoarthritis-initiative
#8
Laura L Laslett, Petr Otahal, Elizabeth M A Hensor, Sarah R Kingsbury, Philip G Conaghan
OBJECTIVE: To assess whether the "spread" of joint pain is related to pain-associated muscle loss in 1 joint leading to increased loading and subsequent pain in other joints. METHODS: Associations between persistent knee pain (pain in 1 or 2 knees over 0-3 years vs no persistent pain) and incident shoulder pain at Year 4 were examined in participants from the longitudinal National Institutes of Health Osteoarthritis Initiative. Associations were assessed using log multinomial modeling, adjusted for age, sex, body mass index, depression score, other lower limb pain, and baseline leg weakness (difficulty standing from a sitting position)...
November 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27775183/asymptomatic-and-symptomatic-individuals-with-the-same-radiographic-evidence-of-knee-osteoarthritis-walk-with-different-knee-moments-and-muscle-activity
#9
Janie L Astephen Wilson, William D Stanish, Cheryl L Hubley-Kozey
There is an established discordance between the structural joint damage and clinical symptoms of knee osteoarthritis; however, there has been little investigation into the differences in joint level biomechanics and muscle activation patterns during gait between symptomatic and asymptomatic individuals with the same radiographic evidence of osteoarthritis. The objective of this study was to examine three-dimensional knee joint biomechanics and muscle activation differences during gait between asymptomatic and symptomatic individuals with radiographic knee osteoarthritis...
October 24, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27761624/comparison-of-the-efficiency-of-an-extra-articular-absorber-system-and-high-tibial-osteotomy-for-unloading-the-medial-knee-compartment-an-in-vitro-study
#10
Gerrit Bode, Ferdinand Kloos, Matthias J Feucht, Benjamin Fleischer, Norbert Südkamp, Philipp Niemeyer, Christoph Becher
PURPOSE: The unloading effect of an extra-articular absorber system on the knee joint medial compartment was compared with high tibial osteotomy (HTO) under physiological conditions in vitro. METHODS: Seven fresh-frozen cadaveric knees were used to test isokinetic flexion-extension motions under physiological loading using a biomechanical knee simulator. Tibiofemoral area contact and peak contact pressures were measured using pressure-sensitive film in the untreated medial compartment...
October 19, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27747918/predictors-of-knee-joint-loading-after-anterior-cruciate-ligament-reconstruction
#11
Elizabeth Wellsandt, Ashutosh Khandha, Kurt Manal, Michael J Axe, Thomas S Buchanan, Lynn Snyder-Mackler
Anterior cruciate ligament (ACL) injury results in altered knee joint mechanics which frequently continue even after ACL reconstruction. The persistence of altered mechanical loading of the knee is of concern due to its likely role in the development of post-traumatic osteoarthritis (OA). Joint contact forces are associated with post-traumatic OA development, but evaluation of factors influencing the magnitude of contact forces after ACL injury is needed to advance current strategies aimed at preventing post-traumatic OA...
October 17, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27729289/association-of-baseline-knee-sagittal-dynamic-joint-stiffness-during-gait-and-2-year-patellofemoral-cartilage-damage-worsening-in-knee-osteoarthritis
#12
Alison H Chang, Joan S Chmiel, Orit Almagor, Ali Guermazi, Pottumarthi V Prasad, Kirsten C Moisio, Laura Belisle, Yunhui Zhang, Karen Hayes, Leena Sharma
OBJECTIVE: Knee sagittal dynamic joint stiffness (DJS) describes the biomechanical interaction between change in external knee flexion moment and flexion angular excursion during gait. In theory, greater DJS may particularly stress the patellofemoral (PF) compartment and thereby contribute to PF osteoarthritis (OA) worsening. We hypothesized that greater baseline knee sagittal DJS is associated with PF cartilage damage worsening 2 years later. METHODS: Participants all had OA in at least one knee...
October 8, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27725941/exercise-alters-gait-pattern-but-not-knee-load-in-patients-with-knee-osteoarthritis
#13
Ssu-Yu Chang, Yi-Jia Lin, Wei-Chun Hsu, Lin-Fen Hsieh, Yuan-Hsiang Lin, Chao-Chin Chang, You-Cai Chou, Li-Fei Chen
Six female patients with bilateral medial knee OA and 6 healthy controls were recruited. Patients with knee OA received a 6-week physiotherapist-supervised and home-based exercise program. Outcome measures, including the Western Ontario and McMaster Universities Arthritis Index and Short Form-36 Health Survey as well as objective biomechanical indices were obtained at baseline and follow-up. After treatment, no significant difference was observed in the knee abductor moment (KAM), lever arm, and ground reaction force...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27693959/long-term-effects-of-lateral-wedge-orthotics-on-hip-and-ankle-joint-space-widths
#14
Mehmet E Tezcan, Berna Goker, Roy Lidtke, Joel A Block
BACKGROUND: Lateral wedge insoles have been used for the treatment of medial knee osteoarthritis (OA) and have been shown to reduce loading of the medial compartment of the knee. However, as the entire lower extremity acts as a single kinetic chain, altering the biomechanics of the knee may also have significant effects at the ankles or hips. We aimed to evaluate the effects of lateral wedge orthotics on ankle and hip joints, compared to neutral orthotics, by assessing the changes in joint space width (JSW) during 36 months of continuous use...
September 21, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27690057/a-mechatronic-loading-device-to-stimulate-bone-growth-via-a-human-knee
#15
Sai Krishna Prabhala, Stanley Chien, Hiroki Yokota, Sohel Anwar
This paper presents the design of an innovative device that applies dynamic mechanical load to human knee joints. Dynamic loading is employed by applying cyclic and periodic force on a target area. The repeated force loading was considered to be an effective modality for repair and rehabilitation of long bones that are subject to ailments like fractures, osteoporosis, osteoarthritis, etc. The proposed device design builds on the knowledge gained in previous animal and mechanical studies. It employs a modified slider-crank linkage mechanism actuated by a brushless Direct Current (DC) motor and provides uniform and cyclic force...
2016: Sensors
https://www.readbyqxmd.com/read/27680888/tibiofemoral-osteoarthritis-and-varus-valgus-laxity
#16
Gregory M Freisinger, Laura C Schmitt, Andrea B Wanamaker, Robert A Siston, Ajit M W Chaudhari
The purpose of this study was to systematically review and synthesize the literature measuring varus-valgus laxity in individuals with tibiofemoral osteoarthritis (OA). Specifically, we aimed to identify varus-valgus laxity differences between persons with OA and controls, by radiographic disease severity, by frontal plane knee alignment, and by sex. We also aimed to identify if there was a relationship between varus-valgus laxity and clinical performance and self-reported function. We systematically searched for peer-reviewed original research articles in PubMed, Scopus, and CINAHL to identify all existing literature regarding knee OA and objective measurement of varus-valgus laxity in vivo...
September 28, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27676899/patient-dependent-knee-modeling-at-several-flexion-angles-a-study-on-soft-tissues-loadings
#17
Boris Dousteyssier, Jérôme Molimard, Chafiaa Hamitouche, Woo Suck Han, Eric Stindel
OBJECTIVE: With cartilage physiopathology, knee stability and therefore the subsequent loadings on ligaments have a strong impact in the development of knee osteoarthritis. To understand this phenomenon, authors are proposing different knee models. Most of them are without any flexion, some have been introduced by controlling actively muscular groups. In this case, the forces used to achieve the flexion may not be physiological, and the pressure on the articulation can be questioned. We propose a mixed approach, both using medical imaging (MRI, EOS X-ray system) and force platform in conjunction with a finite element model...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27669448/knee-joint-loading-during-single-leg-forward-hopping
#18
Rebecca L Krupenevich, Alison L Pruziner, Ross H Miller
: Increased or abnormal loading on the intact limb is thought to contribute to the relatively high risk of knee osteoarthritis (OA) in this limb for individuals with unilateral lower limb loss. This theory has been assessed previously by studying walking, but knee joint loading during walking is often similar between individuals with limb loss and individuals without limb loss, prompting assessment of other movements that may place unusual loads on the knee. One such movement, hopping, is a form of locomotion that individuals with unilateral lower limb loss may situationally use instead of walking, but the mechanical effects of hopping on the intact limb are unknown...
September 16, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27664397/unilateral-hip-osteoarthritis-the-effect-of-compensation-strategies-and-anatomic-measurements-on-frontal-plane-joint-loading
#19
André Schmidt, Andrea Meurer, Katharina Lenarz, Lutz Vogt, Dara Froemel, Frederick Lutz, John Barker, Felix Stief
In order to reduce pain caused by the affected hip joint, unilateral hip osteoarthritis patients (HOAP) adopt characteristic gait patterns. However, it is unknown if the knee and hip joint loading in the non-affected (limbnon-affected ) and the affected (limbaffected ) limb differ from healthy controls (HC) and which gait parameters correlate with potential abnormal joint loading. Instrumented 3D-gait analysis was performed on 18 HOAP and 18 sex, age, and height matched HC. The limbnon-affected showed greater first and second peak external hip adduction moments (first HAM: +15%, p = 0...
September 24, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27648746/does-anterior-cruciate-ligament-innervation-matter-for-joint-function-and-development-of-osteoarthritis
#20
Christopher V Nagelli, James L Cook, Kei Kuroki, Chantelle Bozynski, Richard Ma, Timothy E Hewett
Complications following anterior cruciate ligament (ACL) injury and reconstruction that include chronic dysfunction, second ACL injury, and posttraumatic osteoarthritis (OA) may be interrelated and stem from the inability to fully restore native ACL integrity and function. The loss of ACL sensory input following injury may significantly contribute to joint dysfunction. We developed a novel preclinical animal model to assess the contributions of ACL sensory afferents to knee joint function and health. We hypothesized that ACL sensory denervation would manifest in knee joint dysfunction and development of early OA...
September 20, 2016: Journal of Knee Surgery
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