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https://www.readbyqxmd.com/read/29691371/helicobacter-pylori-induced-il-33-modulates-mast-cell-responses-benefits-bacterial-growth-and-contributes-to-gastritis
#1
Yi-Pin Lv, Yong-Sheng Teng, Fang-Yuan Mao, Liu-Sheng Peng, Jin-Yu Zhang, Ping Cheng, Yu-Gang Liu, Hui Kong, Ting-Ting Wang, Xiao-Long Wu, Chuan-Jie Hao, Weisan Chen, Shi-Ming Yang, Yong-Liang Zhao, Bin Han, Qiang Ma, Quan-Ming Zou, Yuan Zhuang
Interleukin (IL)-induced inflammatory responses are critical for the pathogenesis of Helicobacter pylori (H. pylori)-induced gastritis. IL-33 represents a recently discovered proinflammatory cytokine involved in inflammatory diseases, but its relevance to H. pylori-induced gastritis is unknown. Here, we found that gastric IL-33 mRNA and protein expression were elevated in gastric mucosa of both patients and mice infected with H. pylori, which is positively correlated with bacterial load and the degree of gastritis...
April 25, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29686281/gauging-force-by-tapping-tendons
#2
Jack A Martin, Scott C E Brandon, Emily M Keuler, James R Hermus, Alexander C Ehlers, Daniel J Segalman, Matthew S Allen, Darryl G Thelen
Muscles are the actuators that drive human movement. However, despite many decades of work, we still cannot readily assess the forces that muscles transmit during human movement. Direct measurements of muscle-tendon loads are invasive and modeling approaches require many assumptions. Here, we introduce a non-invasive approach to assess tendon loads by tracking vibrational behavior. We first show that the speed of shear wave propagation in tendon increases with the square root of axial stress. We then introduce a remarkably simple shear wave tensiometer that uses micron-scale taps and skin-mounted accelerometers to track tendon wave speeds in vivo...
April 23, 2018: Nature Communications
https://www.readbyqxmd.com/read/29685524/medial-meniscal-extrusion-detection-evaluation-and-clinical-implications
#3
REVIEW
Nayanatara Swamy, Vibhor Wadhwa, Gitanjali Bajaj, Avneesh Chhabra, Tarun Pandey
The menisci play an important role in knee kinematics. Their unique anatomy allows them to channel forces generated during knee movements through the larger tibio-femoral condylar surfaces while simultaneously resisting deleterious hoop stresses. Although physiologic meniscal extrusion occurs with every knee joint movement, pathologic meniscal extrusion subjects the knee to persistent and excessive load transmission. This renders the knee structures susceptible to injury or exacerbates worsening of existing knee joint internal derangement...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29685388/the-contribution-of-the-posterolateral-capsule-to-elbow-joint-stability-a-cadaveric-biomechanical-investigation
#4
Dafydd S Edwards, Mohammed S Arshad, Toni Luokkala, Angela E Kedgley, Adam C Watts
BACKGROUND: Elbow posterolateral rotatory instability occurs after an injury to the lateral collateral ligament complex (LCLC) in isolation or in association with an osteochondral fracture of the posterolateral margin of the capitellum (Osborne-Cotterill lesion [OCL]). The contribution to elbow stability of the posterolateral capsule, attached to this lesion, is unknown. This study quantified the displacement of the radial head on simulated posterior draw with sectioning of the posterior capsule (a simulated OCL) or LCLC...
April 20, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29684979/the-degree-of-arm-elevation-impacts-the-endurance-and-cardiopulmonary-adaptations-of-copd-patients-performing-upper-limb-exercise-a-cross-over-study
#5
Mara Paneroni, Carla Simonelli, Pierantonio Laveneziana, Massimiliano Gobbo, Manuela Saleri, Luca Bianchi, Michele Vitacca
BACKGROUND: In Chronic Obstructive Pulmonary Disease (COPD), upper limb exercise is widely recommended. However, how the degree of shoulder flexion may influence the exercise response is unknown. AIM: We compared metabolic, ventilatory and symptomatic responses during constant-load supported and unsupported exercise performed at 80° and 120° arm elevation. DESIGN: Randomized cross-over study. SETTING: Pulmonary Pathophysiology Service in an Italian Respiratory Rehabilitative Division, in-patients were enrolled...
April 20, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29684886/the-effects-of-three-quarter-and-full-length-foot-orthoses-on-knee-mechanics-in-healthy-subjects-and-patellofemoral-pain-patients-when-walking-and-descending-stairs
#6
J Burston, J Richards, J Selfe
BACKGROUND: An increased load of the patellofemoral joint is often attributed to foot function in patients with patellofemoral pain. Foot orthoses are commonly prescribed for this condition; however the mechanisms by which they work are poorly understood. The aim of this study was to investigate the kinematics and kinetics of the knee between patellofemoral pain patients and a group of healthy subjects when using a standardised foot orthosis prescription during walking and step descent...
April 17, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29683374/finite-element-analysis-of-the-effect-of-high-tibial-osteotomy-correction-angle-on-articular-cartilage-loading
#7
Zahra Trad, Abdelwahed Barkaoui, Moez Chafra, João Manuel Rs Tavares
Osteoarthritis is a globally common disease that imposes a considerable ongoing health and economic burden on the socioeconomic system. As more and more biomechanical factors have been explored, malalignment of the lower limb has been found to influence the load distribution across the articular surface of the knee joint substantially. In this work, a three-dimensional finite element analysis was carried out to investigate the effect of varying the high tibial osteotomy correction angle on the stress distribution in both compartments of the human knee joint...
April 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29682285/effects-of-interfacial-micromotions-on-vitality-and-differentiation-of-human-osteoblasts
#8
J Ziebart, S Fan, C Schulze, P W Kämmerer, R Bader, A Jonitz-Heincke
Objectives: Enhanced micromotions between the implant and surrounding bone can impair osseointegration, resulting in fibrous encapsulation and aseptic loosening of the implant. Since the effect of micromotions on human bone cells is sparsely investigated, an in vitro system, which allows application of micromotions on bone cells and subsequent investigation of bone cell activity, was developed. Methods: Micromotions ranging from 25 µm to 100 µm were applied as sine or triangle signal with 1 Hz frequency to human osteoblasts seeded on collagen scaffolds...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29682282/a-pilot-hole-does-not-reduce-the-strains-or-risk-of-fracture-to-the-lateral-cortex-during-and-following-a-medial-opening-wedge-high-tibial-osteotomy-in-cadaveric-specimens
#9
K Bujnowski, A Getgood, K Leitch, J Farr, C Dunning, T A Burkhart
Aim: It has been suggested that the use of a pilot-hole may reduce the risk of fracture to the lateral cortex. Therefore the purpose of this study was to determine the effect of a pilot hole on the strains and occurrence of fractures at the lateral cortex during the opening of a high tibial osteotomy (HTO) and post-surgery loading. Materials and Methods: A total of 14 cadaveric tibias were randomized to either a pilot hole (n = 7) or a no-hole (n = 7) condition...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29681405/perturbation-velocity-affects-linearly-estimated-neuromechanical-wrist-joint-properties
#10
Asbjørn Klomp, Erwin de Vlugt, Jurriaan H de Groot, Carel G M Meskers, J Hans Arendzen, Frans C T van der Helm
The dynamic behavior of the wrist joint is governed by nonlinear properties, yet applied mathematical models, used to describe the measured input-output (perturbation-response) relationship, are commonly linear. Consequently, the linearly estimated model parameters will depend on properties of the applied perturbation properties (such perturbation amplitude and velocity). We aimed to systematically address the effects of perturbation velocity on linearly estimated neuromechanical parameters. Using a single axis manipulator ramp and hold perturbations were applied to the wrist joint...
April 12, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29680494/femur-loading-in-feet-first-fall-experiments-using-an-anthropomorphic-test-device
#11
Angela Thompson, Gina Bertocci, Craig Smalley
BACKGROUND: Femur fractures are a common orthopedic injury in young children. Falls account for a large portion of accidental femur fractures in young children, but there is also a high prevalence of femur fractures in child abuse, with falls often provided as false histories. Objective information regarding fracture potential in short distance fall scenarios may aid in assessing whether a child's injuries are the result of abuse or an accidental fall. Knowledge of femur loading is the first step towards understanding likelihood of fracture in a fall...
March 31, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29680325/effects-of-severe-hallux-valgus-on-metatarsal-stress-and-the-metatarsophalangeal-loading-during-balanced-standing-a-finite-element-analysis
#12
Yan Zhang, Jan Awrejcewicz, Olga Szymanowska, Siqin Shen, Xiaoxue Zhao, Julien S Baker, Yaodong Gu
The internal stress of the human foot enables efficient parametric evaluation of structural and functional impairments associated with foot deformities, such as hallux valgus (HV). However, the status of the internal stress of such a deformed foot remains insufficiently addressed due to the difficulties and limitations of experimental approaches. This study, using finite element (FE) methodology, investigated the influence of severe HV deformity on the metatarsal stress and the metatarsophalangeal (MTP) joint loading during balanced standing...
April 16, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29679945/occurrence-elimination-enantiomeric-distribution-and-intra-day-variations-of-chiral-pharmaceuticals-in-major-wastewater-treatment-plants-in-beijing-china
#13
Lei Duan, Yizhe Zhang, Bin Wang, Shubo Deng, Jun Huang, Yujue Wang, Gang Yu
The occurrence, eliminations, enantiomeric distribution and intra-day variations of five chiral pharmaceuticals (three beta-blockers and two antidepressants) were investigated in eight major WWTPs in Beijing, China. The results revealed that metoprolol (MTP) and venlafaxine (VFX) were of the highest concentrations among the five determined pharmaceuticals with mean concentrations of 803 ng L-1 and 408 ng L-1 , respectively in influents, and 354 ng L-1 and 165 ng L-1 in effluents, respectively...
April 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29679400/the-development-of-hoof-balance-and-landing-preference-in-the-postnatal-period
#14
B M C Gorissen, F M Serra Bragança, C F Wolschrijn, W Back, P R van Weeren
BACKGROUND: Foals can follow the herd within hours of birth, but it has been shown that kinetic gait parameters and static balance still have to mature. However, development of dynamic balance has not been investigated. OBJECTIVES: To objectively quantify landing and pressure pattern dynamics under the hoof during the first half year of life. STUDY DESIGN: Prospective, cohort study performed at a single stud farm. METHODS: Pressure plate measurements at walk and trot from ten Dutch warmblood foals during the first 24 weeks of life were used to quantify toe-heel and medial-lateral hoof balance asymmetry indexes and to determine preferred landing strategy...
April 20, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29679256/biomechanical-features-of-six-design-of-the-delta-external-fixator-for-treating-pilon-fracture-a-finite-element-study
#15
Muhammad Hanif Ramlee, Mohd Ayub Sulong, Evelyn Garcia-Nieto, Daniel Angure Penaranda, Antonio Ros Felip, Mohammed Rafiq Abdul Kadir
Pilon fractures can be caused by high-energy vertical forces which may result in long-term patient immobilization. Many experts in orthopedic surgery recommend the use of a Delta external fixator for type III Pilon fracture treatment. This device can promote immediate healing of fractured bone, minimizing the rate of complications as well as allowing early mobilization. The characteristics of different types of the Delta frame have not been demonstrated yet. By using the finite element method, this study was conducted to determine the biomechanical characteristics of six different configurations (Model 1 until Model 6)...
April 21, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29676169/thirty-minutes-of-running-exercise-decreases-t2-signal-intensity-but-not-thickness-of-the-knee-joint-cartilage-a-3-0-t-magnetic-resonance-imaging-study
#16
Yiğitcan Karanfil, Naila Babayeva, Gürhan Dönmez, H Barış Diren, Muzaffer Eryılmaz, Mahmut Nedim Doral, Feza Korkusuz
Objective Recent studies showed a potential of magnetic resonance imaging (MRI), which can be used as an additional tool for diagnosing cartilage degeneration in the early stage. We designed a cross-sectional study in order to evaluate knee joint cartilage adaptation to running, using 3.0-T MRI equipped with the 3-dimensional turbo spin echo (VISTA = Volume ISotropic Turbo spin echo Acquisition) software. By this thickness (mm) and signal intensity (mean pixel value) can be quantified, which could be closely related to the fluid content of the knee joint cartilage, before and after running...
April 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29673934/foot-structure-and-knee-joint-kinetics-during-walking-with-and-without-wedged-footwear-insoles
#17
Ryan T Lewinson, Ryan Madden, Anthony Killick, John W Wannop, J Preston Wiley, Victor M Y Lun, Chirag Patel, Jeremy M LaMothe, Darren J Stefanyshyn
The relationship between static foot structure characteristics and knee joint biomechanics during walking, or the biomechanical response to wedged insoles are currently unknown. In this study, 3D foot scanning, dual X-ray absorptiometry and gait analysis methods were used to determine structural parameters of the foot and assess their relation to knee joint loading and biomechanical response to wedged insoles in 30 patients with knee osteoarthritis. In multiple linear regression models, foot fat content, height of the medial longitudinal arch and static hind foot angle were not associated with the magnitude of the knee adduction moment (R2  = 0...
April 12, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29672352/association-of-activities-of-daily-living-with-the-load-during-step-ascent-motion-in-nursing-home-residing-elderly-individuals
#18
Mitsuhiro Masaki, Tome Ikezoe, Midori Kamiya, Kojiro Araki, Ryo Isono, Takehiro Kato, Ken Kusano, Masayo Tanaka, Syunsuke Sato, Tetsuya Hirono, Kiyoshi Kita, Tadao Tsuboyama, Noriaki Ichihashi
OBJECTIVE: This study aimed to examine the association of independence in ADL with the loads during step ascent motion and other motor functions in 32 nursing home-residing elderly individuals. DESIGN: Independence in ADL was assessed by using the functional independence measure (FIM). The loads at the upper (i.e., pulling up) and lower (i.e., pushing up) levels during step ascent task was measured on a step ascent platform. Hip extensor, knee extensor, plantar flexor muscle, and quadriceps setting strengths; lower extremity agility using the stepping test; and hip and knee joint pain severities were measured...
April 19, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29671348/four-strand-versus-2-strand-suture-button-constructs-in-first-carpometacarpal-arthroplasty-a-biomechanical-study
#19
Beatrice L Grasu, Andrew J Trontis, Brent G Parks, Raymond A Wittstadt
BACKGROUND: Suture-button fixation is an alternative to no fixation, first metacarpal distraction techniques, or Kirschner wire fixation after trapeziectomy in treatment of first carpometacarpal (CMC) arthritis. A 4-strand suture-button construct requires a 2.7-mm tunnel, whereas a 2-strand construct requires a 1.1-mm tunnel, potentially decreasing the risk of metacarpal fracture. We compared stability and failure criteria of 4-strand versus 2-strand construct in a biomechanical model of first CMC joint arthroplasty...
April 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29671152/predictive-simulations-of-neuromuscular-coordination-and-joint-contact-loading-in-human-gait
#20
Yi-Chung Lin, Jonathan P Walter, Marcus G Pandy
We implemented direct collocation on a full-body neuromusculoskeletal model to calculate muscle forces, ground reaction forces and knee contact loading simultaneously for one cycle of human gait. A data-tracking collocation problem was solved for walking at the normal speed to establish the practicality of incorporating a 3D model of articular contact and a model of foot-ground interaction explicitly in a dynamic optimization simulation. The data-tracking solution then was used as an initial guess to solve predictive collocation problems, where novel patterns of movement were generated for walking at slow and fast speeds, independent of experimental data...
April 18, 2018: Annals of Biomedical Engineering
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