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https://www.readbyqxmd.com/read/29232392/experimental-and-numerical-study-of-the-failure-process-and-energy-mechanisms-of-rock-like-materials-containing-cross-un-persistent-joints-under-uniaxial-compression
#1
Rihong Cao, Ping Cao, Hang Lin, Xiang Fan
Joints and fissures in natural rocks have a significant influence on the stability of the rock mass, and it is often necessary to evaluate strength failure and crack evolution behavior. In this paper, based on experimental tests and numerical simulation (PFC2D), the macro-mechanical behavior and energy mechanism of jointed rock-like specimens with cross non-persistent joints under uniaxial loading were investigated. The focus was to study the effect of joint dip angle α and intersection angle γ on the characteristic stress, the coalescence modes and the energy release of jointed rock-like specimens...
2017: PloS One
https://www.readbyqxmd.com/read/29230427/biomechanical-comparison-of-single-versus-double-row-capsulolabral-repair-for-shoulder-instability-a-review
#2
REVIEW
Matthew John Yousif, James Bicos
Background: The glenohumeral joint is the most commonly dislocated joint in the body. Failure rates of capsulolabral repair have been reported to be approximately 8%. Recent focus has been on restoration of the capsulolabral complex by a double-row capsulolabral repair technique in an effort to decrease redislocation rates after arthroscopic capsulolabral repair. Purpose: To present a review of the biomechanical literature comparing single- versus double-row capsulolabral repairs and discuss the previous case series of double-row fixation...
December 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29230389/cyclic-tensile-strain-can-play-a-role-in-directing-both-intramembranous-and-endochondral-ossification-of-mesenchymal-stem-cells
#3
Simon F Carroll, Conor T Buckley, Daniel J Kelly
Successfully regenerating damaged or diseased bone and other joint tissues will require a detailed understanding of how joint specific environmental cues regulate the fate of progenitor cells that are recruited or delivered to the site of injury. The goal of this study was to explore the role of cyclic tensile strain (CTS) in regulating the initiation of mesenchymal stem cell/multipotent stromal cell (MSC) differentiation, and specifically their progression along the endochondral pathway. To this end, we first explored the influence of CTS on the differentiation of MSCs in the absence of any specific growth factor, and secondly, we examined the influence of the long-term application of this mechanical stimulus on markers of endochondral ossification in MSCs maintained in chondrogenic culture conditions...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29227919/a-subject-specific-biomechanical-control-model-for-the-prediction-of-cervical-spine-muscle-forces
#4
Maxim Van den Abbeele, Fan Li, Vincent Pomero, Dominique Bonneau, Baptiste Sandoz, Sébastien Laporte, Wafa Skalli
BACKGROUND: The aim of the present study is to propose a subject-specific biomechanical control model for the estimation of active cervical spine muscle forces. METHODS: The proprioception-based regulation model developed by Pomero et al. (2004) for the lumbar spine was adapted to the cervical spine. The model assumption is that the control strategy drives muscular activation to maintain the spinal joint load below the physiological threshold, thus avoiding excessive intervertebral displacements...
December 6, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29222607/static-and-fatigue-strength-of-a-novel-anatomically-contoured-implant-compared-to-five-current-open-wedge-high-tibial-osteotomy-plates
#5
Arnaud Diffo Kaze, Stefan Maas, James Belsey, Alexander Hoffmann, Dietrich Pape
BACKGROUND: The purpose of the present study was to compare the mechanical static and fatigue strength of the size 2 osteotomy plate "Activmotion" with the following five other common implants for the treatment of medial knee joint osteoarthritis: the TomoFix small stature, the TomoFix standard, the Contour Lock, the iBalance and the second generation PEEKPower. METHODS: Six fourth-generation tibial bone composites underwent a medial open-wedge high tibial osteotomy (HTO), according to standard techniques, using size 2 Activmotion osteotomy plates...
December 8, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29221903/discrete-element-analysis-is-a-valid-method-for-computing-joint-contact-stress-in-the-hip-before-and-after-acetabular-fracture
#6
Kevin C Townsend, Holly D Thomas-Aitken, M James Rudert, Andrew M Kern, Michael C Willey, Donald D Anderson, Jessica E Goetz
Evaluation of abnormalities in joint contact stress that develop after inaccurate reduction of an acetabular fracture may provide a potential means for predicting the risk of developing post-traumatic osteoarthritis. Discrete element analysis (DEA) is a computational technique for calculating intra-articular contact stress distributions in a fraction of the time required to obtain the same information using the more commonly employed finite element analysis technique. The goal of this work was to validate the accuracy of DEA-computed contact stress against physical measurements of contact stress made in cadaveric hips using Tekscan sensors...
November 16, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29221427/validity-of-the-dutch-modified-paindetect-questionnaire-for-patients-with-hip-or-knee-osteoarthritis
#7
Wietske Rienstra, Tim Blikman, Baukje Dijkstra, Jos van Raay, Geranda Slager, Sjoerd Bulstra, Martin Stevens, Inge van den Akker-Scheek
BACKGROUND: The modified painDETECT questionnaire (PDQ) is a self-reported questionnaire to discriminate between nociceptive and neuropathic-like pain in patients with knee/hip osteoarthritis (OA). This study aims to assess the structural and construct validity of this questionnaire. METHODS: Confirmatory factor analysis and hypothesis-testing was used. For 168 patients, predefined hypotheses were formulated on the correlation between the modified painDETECT and several other questionnaires, and in a subsample of 46 with pain pressure thresholds (PPTs)...
December 8, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29220677/a-powerful-approach-to-estimating-annotation-stratified-genetic-covariance-via-gwas-summary-statistics
#8
Qiongshi Lu, Boyang Li, Derek Ou, Margret Erlendsdottir, Ryan L Powles, Tony Jiang, Yiming Hu, David Chang, Chentian Jin, Wei Dai, Qidu He, Zefeng Liu, Shubhabrata Mukherjee, Paul K Crane, Hongyu Zhao
Despite the success of large-scale genome-wide association studies (GWASs) on complex traits, our understanding of their genetic architecture is far from complete. Jointly modeling multiple traits' genetic profiles has provided insights into the shared genetic basis of many complex traits. However, large-scale inference sets a high bar for both statistical power and biological interpretability. Here we introduce a principled framework to estimate annotation-stratified genetic covariance between traits using GWAS summary statistics...
December 7, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29216405/the-human-immunodeficiency-virus-care-continuum-in-china-1985-2015
#9
Ye Ma, Zhihui Dou, Wei Guo, Yurong Mao, Fujie Zhang, Jennifer M McGoogan, Yan Zhao, Decai Zhao, Yasong Wu, Zhongfu Liu, Zunyou Wu
Background: Human immunodeficiency virus (HIV) care continuum attrition is a major global public health challenge. Few studies have examined this problem in resource-limited settings. We aimed to assess cumulative, current, and historical achievement along China's HIV continuum of care. Methods: A nationwide, serial cross-sectional study of all individuals with HIV infection diagnosed in China between 1 January 1985 and 31 December 2015 was conducted using data from China's HIV/AIDS information systems...
December 5, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29212516/a-finite-element-model-of-the-lower-limb-during-stance-phase-of-gait-cycle-including-the-muscle-forces
#10
Arnaud Diffo Kaze, Stefan Maas, Pierre-Jean Arnoux, Claude Wolf, Dietrich Pape
BACKGROUND: Results of finite element (FE) analyses can give insight into musculoskeletal diseases if physiological boundary conditions, which include the muscle forces during specific activities of daily life, are considered in the FE modelling. So far, many simplifications of the boundary conditions are currently made. This study presents an approach for FE modelling of the lower limb for which muscle forces were included. METHODS: The stance phase of normal gait was simulated...
December 7, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29210020/effects-of-visual-and-cognitive-interference-on-joint-contributions-in-perturbed-standing-a-temporal-and-spectral-analysis
#11
Mohammed N Ashtiani, Mahmood-Reza Azghani
Postural balance requires using joint strategies which may be changed from normal conditions by interfering with the sensory information. The goal of the present study was to quantitatively evaluate the role of the joint mechanisms during perturbed stance. Visual and cognitive interference was imposed to sixteen healthy young males under rotational toes-down or up perturbations. Power spectral analysis was employed to distinguish the joint contribution and their in- or out-phase co-works. Results showed that addition of cognitive loads reduce the stability by increasing the center of mass (CoM) power to three times greater...
December 5, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29208903/a-novel-bioreactor-system-for-biaxial-mechanical-loading-enhances-the-properties-of-tissue-engineered-human-cartilage
#12
Christoph Meinert, Karsten Schrobback, Dietmar W Hutmacher, Travis J Klein
The ex vivo engineering of autologous cartilage tissues has the potential to revolutionize the clinical management of joint disorders. Yet, high manufacturing costs and variable outcomes associated with tissue-engineered implants are still limiting their application. To improve clinical outcomes and facilitate a wider use of engineered tissues, automated bioreactor systems capable of enhancing and monitoring neotissues are required. Here, we developed an innovative system capable of applying precise uni- or biaxial mechanical stimulation to developing cartilage neotissues in a tightly controlled and automated fashion...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29205214/biomechanics-of-the-shoulder-girdle-a-case-study-on-the-effects-of-union-rugby-tackles
#13
Luís Faria, Bárbara Campos, Renato Natal Jorge
PURPOSE: The shoulder girdle is a complex system, comprised by a kinematic chain and stabilizers. Due to the delicate equilibrium and synchronism between mobility and stability, high external loads may compromise its physiology, increasing the risk of injuries. Thus, this study intends to fully characterize the effects of a rugby tackle on the shoulder's anatomy and physiology. METHODS: For the experimental procedures, a matrix of pressure sensors was used, based on the Teckscan® pressure in-soles, force plates, an isokinetic dynamometer and sEMG (surface electromyography)...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29204861/kinematically-aligned-total-knee-arthroplasty-reduces-knee-adduction-moment-more-than-mechanically-aligned-total-knee-arthroplasty
#14
Yasuo Niki, Takeo Nagura, Katsuya Nagai, Shu Kobayashi, Kengo Harato
PURPOSE: Knee adduction moment (KAM) has been recognized as a good clinical surrogate for medial tibiofemoral joint loading and is associated with implant durability after total knee arthroplasty (TKA). This study aimed to examine the effects of joint line obliquity in kinematically aligned TKA (KA-TKA) on KAM during gait. METHODS: The study enrolled 21 knees from 18 patients who underwent cylindrical axis reference KA-TKA and a matched group of 21 knees from 18 patients who underwent mechanically aligned (MA)-TKA as controls...
December 4, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29203949/simultaneous-wireless-power-transfer-and-data-communication-using-synchronous-pulse-controlled-load-modulation
#15
Shitong Mao, Hao Wang, Chunbo Zhu, Zhi-Hong Mao, Mingui Sun
Wireless Power Transfer (WPT) and wireless data communication are both important problems of research with various applications, especially in medicine. However, these two problems are usually studied separately. In this work, we present a joint study of both problems. Most medical electronic devices, such as smart implants, must have both a power supply to allow continuous operation and a communication link to pass information. Traditionally, separate wireless channels for power transfer and communication are utilized, which complicate the system structure, increase power consumption and make device miniaturization difficult...
October 2017: Measurement: Journal of the International Measurement Confederation
https://www.readbyqxmd.com/read/29202986/arthrodesis-of-the-first-metatarsophalangeal-joint-a-biomechanical-comparison-of-four-fixation-techniques
#16
Ella Harris, Paul Moroney, Yves Tourné
BACKGROUND: Arthrodesis of the first metatarsophalangeal joint is a commonly performed orthopaedic procedure. The optimum method of fixation and joint surface preparation has yet to be determined. METHODS: This study compared four fixation techniques: Biomechanical grade sawbones were used. The dorsal plate used was a titanium, anatomically contoured locked plate. Testing was performed using an Instron machine applying force from the plantar aspect of the fused joint...
December 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29202983/influence-of-tibialis-posterior-muscle-activation-on-foot-anatomy-under-axial-loading-a-biomechanical-ct-human-cadaveric-study
#17
Koen Dullaert, Jennifer E Hagen, Paul Simons, Florian Gras, Boyko Gueorguiev, R Geoff Richards, Kajetan Klos
BACKGROUND: Collapse of the medial longitudinal arch and subluxation of the subtalar joint are common occurrences in adult flatfoot deformity. Controversy exists about the role of the tibialis posterior (TP) tendon as first and/or essential lesion. Subtle changes in the foot configuration can occur under weight bearing. PURPOSE: This human cadaveric study is designed to investigate the effect that isolated actuation of the TP tendon has on the medial longitudinal arch and the hindfoot configuration under simulated weight bearing...
December 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29202874/sensitive-detection-of-hiv-1-resistance-to-zidovudine-and-impact-on-treatment-outcomes-in-low-to-middle-income-countries
#18
Richard M Gibson, Gabrielle Nickel, Michael Crawford, Fred Kyeyune, Colin Venner, Immaculate Nankya, Eva Nabulime, Emmanuel Ndashimye, Art F Y Poon, Robert A Salata, Cissy Kityo, Peter Mugyenyi, Miguel E Quiñones-Mateu, Eric J Arts
BACKGROUND: Thymidine analogs, namely AZT (Zidovudine or Retrovir™) and d4T (Stavudine or Zerit™) are antiretroviral drugs still employed in over 75% of first line combination antiretroviral therapy (cART) in Kampala, Uganda despite aversion to prescribing these drugs for cART in high income countries due in part to adverse events. For this study, we explored how the continued use of these thymidine analogs in cART could impact emergence of drug resistance and impact on future treatment success in Uganda, a low-income country...
December 4, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29201301/effects-of-different-angles-of-the-traction-table-on-lumbar-spine-ligaments-a-finite-element-study
#19
Hekmat Farajpour, Nima Jamshidi
Background: The traction bed is a noninvasive device for treating lower back pain caused by herniated intervertebral discs. In this study, we investigated the impact of the traction bed on the lower back as a means of increasing the disc height and creating a gap between facet joints. Methods: Computed tomography (CT) images were obtained from a female volunteer and a three-dimensional (3D) model was created using software package MIMICs 17.0. Afterwards, the 3D model was analyzed in an analytical software (Abaqus 6...
December 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/29199191/an-animal-model-of-reconstruction-of-single-femoral-tunnel-with-single-bone-bi-quadruple-acl-and-internal-fixation
#20
T Gong, X-T Su, Q Xia, J-G Wang
We introduced several variables in an animal model of anterior cruciate ligament (ACL) reconstruction to determine the best parameters for surgery in humans. We divided 130 LYD pigs into two groups depending on whether the femoral tunnel goes through the medial tibial tunnel or through the medial fossa of the knee joint. Each subgroup was further divided. Four weeks after surgery the knee specimens were examined for passive flexion and extension test. No group showed a creep effect. In the biomechanical tests, we recorded maximal strength, maximum load, and stiffness parameters...
December 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
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