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https://www.readbyqxmd.com/read/28102559/effect-of-bone-like-hydroxyapatite-poly-amino-acid-loaded-with-rifapentine-microspheres-on-bone-and-joint-tuberculosis-in-vitro
#1
Yuwu Liu, Dianming Jiang
Rifapentine-loaded poly(lactic-co-glycolic acid) microspheres (RPMs)-loaded bone-like hydroxyapatite/poly amino acid (BHA/PAA) is effective in curing S. aureus-induced chronic osteomyelitis. This study continues to investigate the effect of RPM-loaded BHA/PAA on the bacterial growth of Mycobacterium tuberculosis (MTB), cell proliferation and differentiation in MTB H37Rv-infected MG63 cells. Furthermore, whether Wnt/β-catenin signaling pathway was activated by RPM-loaded BHA/PAA was explored. We found the bactec growth index of H37Rv was significantly inhibited by RPM-loaded BHA/PAA...
January 19, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28101732/the-analysis-of-knee-joint-loading-during-drop-landing-from-different-heights-and-under-different-instruction-sets-in-healthy-males
#2
Dmitry Verniba, Jason D Vescovi, David A Hood, William H Gage
BACKGROUND: Mechanical loading during exercise has been shown to promote tissue remodeling. Safe and accessible exercise may be beneficial to populations at risk of diminished bone and joint health. We examined the effect of drop height and instruction on knee loading during a drop-landing task and proposed a task that makes use of drop heights that may be appropriate for rehabilitation purposes and functional in daily life to examine transient knee joint loads. METHODS: Twenty males (22...
December 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28101590/-minimally-invasive-treatment-of-intra-articular-calcaneal-fractures-with-the-2%C3%A2-point-distractor
#3
G Mattiassich, W Litzlbauer, M Ponschab, R Ortmaier, C Rodemund
OBJECTIVE: Open treatment of calcaneus fractures often has an increased risk of wound healing. Minimally invasive treatment with small incisions reduces complications. INDICATIONS: Calcaneal fractures with malalignment/comminution >1-2 mm; broadening, varus alignment of the calcaneal length axis or shortening; emergency surgery for open fractures or compartment syndrome. CONTRAINDICATIONS: Local or general contraindications. SURGICAL TECHNIQUE: Standardised positioning; restoration of length/axis with 2‑point distractor under fluoroscopic control...
January 18, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28101145/impact-of-physical-activity-and-mechanical-loading-on-biomarkers-typically-used-in-osteoarthritis-assessment-current-concepts-and-knowledge-gaps
#4
REVIEW
Nicole M Cattano, Jeffrey B Driban, Kenneth L Cameron, Michael R Sitler
There is an ongoing need to develop prognostic and diagnostic biomarkers for osteoarthritis (OA). Understanding how biomarkers change in response to physical activity may be vital for understanding if a patient has a joint that is failing to adapt to a given loading stimulus. The purpose of this review is to describe how biomarker changes after joint loading may help detect early OA and determine prognosis. This may help to inform and more specifically target interventions and clinical trials. We conducted a critical review of the relevant literature that was published to January 2016...
January 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28097087/identification-of-the-vascular-endothelial-growth-factor-signalling-pathway-by-quantitative-proteomic-analysis-of-rat-condylar-cartilage
#5
Liting Jiang, Yinyin Xie, Li Wei, Qi Zhou, Xing Shen, Xinquan Jiang, Yiming Gao
Angiogenesis mediated by vascular endothelial growth factor (VEGF) is known to play an important role in regulating cartilage remodelling and endochondral ossification. However, the details of how VEGF signalling mechanisms affect condyle remodelling in response to alterations in functional loading remains unclear. To explore this, eighty 16-day-old male SD rats were divided into two equal groups which were fed either a soft/powdery diet or a hard diet for 4 weeks; the stiffness of the diet results in alteration of mastication force and hence temporomandibular joint (TMJ) development...
January 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28097064/phalangeal-joints-kinematics-during-ostrich-struthio-camelus-locomotion
#6
Rui Zhang, Qiaoli Ji, Gang Luo, Shuliang Xue, Songsong Ma, Jianqiao Li, Lei Ren
The ostrich is a highly cursorial bipedal land animal with a permanently elevated metatarsophalangeal joint supported by only two toes. Although locomotor kinematics in walking and running ostriches have been examined, these studies have been largely limited to above the metatarsophalangeal joint. In this study, kinematic data of all major toe joints were collected from gaits with double support (slow walking) to running during stance period in a semi-natural setup with two selected cooperative ostriches. Statistical analyses were conducted to investigate the effect of locomotor gait on toe joint kinematics...
2017: PeerJ
https://www.readbyqxmd.com/read/28095108/the-relationship-between-2d-knee-valgus-angle-during-single-leg-squat-single-leg-land-and-drop-jump-screening-tests
#7
Allan Munro, Lee Herrington, Paul Comfort
CONTEXT: Anterior Cruciate Ligament (ACL) and Patellofemoral Joint (PFJ) injuries are a significant problem among female athletes. A number of screening tasks have been used in the literature to identify those at greatest risk of injury. To date, no study has examined the relationship in two-dimensional (2D) knee valgus between common screening tasks to determine whether individuals exhibit similar movement patterns across tasks. OBJECTIVE: to establish whether frontal plane projection angle (FPPA) during the single leg squat (SLS), single leg land (SLL) and drop jump (DJ) are related...
January 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28095094/female-age-related-differences-in-biomechanics-and-muscle-activity-during-descents-on-the-outstretched-arms
#8
Lauren Jane Lattimer, Joel Lanovaz, Jon Farthing, Stéphanie Madill, Soo Kim, Stephen Robinovitch, Cathy Arnold
The purposes of this study were to examine female age differences in: 1) upper extremity (UE) and trunk muscle activity, elbow joint moment, loading force and UE energy absorption during a controlled forward body descent and 2) UE muscle strength. Twenty young (mean 24.8±3.4 yrs.) and 20 older (68.4±5.7 yrs.) women were assessed via dynamometry for isometric, concentric and eccentric UE strength and performed forward descents on force plates at three body lean angles (60, 45, and 30° from horizontal). Significant differences (p < ...
January 17, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28094763/measuring-the-effect-of-femoral-malrotation-on-knee-joint-biomechanics-for-total-knee-arthroplasty-using-computational-simulation
#9
K-T Kang, Y-G Koh, J Son, O-R Kwon, C Baek, S H Jung, K K Park
OBJECTIVES: Malrotation of the femoral component can result in post-operative complications in total knee arthroplasty (TKA), including patellar maltracking. Therefore, we used computational simulation to investigate the influence of femoral malrotation on contact stresses on the polyethylene (PE) insert and on the patellar button as well as on the forces on the collateral ligaments. MATERIALS AND METHODS: Validated finite element (FE) models, for internal and external malrotations from 0° to 10° with regard to the neutral position, were developed to evaluate the effect of malrotation on the femoral component in TKA...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/28094418/comparative-anatomy-and-biomechanical-properties-of-atlantoaxial-ligaments-in-equine-bovine-and-canine-cadaveric-specimens
#10
Franck Forterre, Michael H Stoffel, Christoph Koch, Christina Precht, Maja Waschk, Alexander Bürki
OBJECTIVES: Atlantoaxial instability has been reported in humans, dogs, equids and ruminants. The functional role of the atlantoaxial ligaments has only been described rudimentarily in equids and ruminants. The goal of the present cadaveric study was to compare the anatomy between the different species and to comparatively assess the role of the stabilizing ligaments of the atlantoaxial joint under sagittal shear loading in canine, equine, and bovine cervical spines. METHODS: Three equine, bovine, and canine cadaveric specimens were investigated...
January 17, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28094241/gelatin-freeze-casting-of-biomimetic-titanium-alloy-with-anisotropic-and-gradient-pore-structure
#11
Lei Zhang, Ronan Le Coz-Botrel, Charlotte Beddoes, Terje Sjöström, Bo Su
Titanium is a material commonly used for dental and orthopaedic implants. However, due to large differences in properties between the titanium metal and the natural bone, stress shielding has been observed in the surrounding area, resulting in bone atrophy, and thus has raised concerns of the use of this material. Ideally implant materials should possess similar properties to the surrounding tissues in order to distribute the load as the joint would naturally, while also possessing a similar porous structure to the bone to enable interaction with the surrounding material...
January 17, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28093922/toll-like-receptors-and-their-soluble-forms-differ-in-the-knee-and-thumb-basal-osteoarthritic-joints
#12
Goncalo Barreto, Jerker Sandelin, Abdelhakim Salem, Dan C Nordström, Eero Waris
Background and purpose - Although the pathogenesis of osteoarthritis (OA) is not well understood, chondrocyte-mediated inflammatory responses (triggered by the activation of innate immune receptors by damage-associated molecules) are thought to be involved. We examined the relationship between Toll-like receptors (TLRs) and OA in cartilage from 2 joints differing in size and mechanical loading: the first carpometacarpal (CMC-I) and the knee. Patients and methods - Samples of human cartilage obtained from OA CMC-I and knee joints were immunostained for TLRs (1-9) and analyzed using histomorphometry and principal component analysis (PCA)...
January 17, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28093261/experimental-evaluation-of-a-new-morphological-approximation-of-the-articular-surfaces-of-the-ankle-joint
#13
Claudio Belvedere, Sorin Siegler, Andrea Ensini, Jason Toy, Paolo Caravaggi, Ramya Namani, Giulia Giannini, Stefano Durante, Alberto Leardini
The mechanical characteristics of the ankle such as its kinematics and load transfer properties are influenced by the geometry of the articulating surfaces. A recent, image-based study found that these surfaces can be approximated by a saddle-shaped, skewed, truncated cone with its apex oriented laterally. The goal of this study was to establish a reliable experimental technique to study the relationship between the geometry of the articular surfaces of the ankle and its mobility and stability characteristics and to use this technique to determine if morphological approximations of the ankle surfaces based on recent discoveries, produce close to normal behavior...
January 7, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28089359/transient-and-long-time-kinetic-responses-of-the-cadaveric-leg-during-internal-and-external-foot-rotation
#14
Alexander R Mait, Adwait Mane, Jason L Forman, John Paul Donlon, Bingbing Nie, Richard W Kent
The purpose of this study was to determine the long-time and transient characteristics of the moment generated by external (ER) and internal (IR) rotation of the calcaneus with respect to the tibia. Two human cadaver legs were disarticulated at the knee joint while maintaining the connective tissue between the tibia and fibula. An axial rotation of 21° was applied to the proximal tibia to generate either ER or IR while the fibula was unconstrained and the calcaneus was permitted to translate in the transverse plane...
January 7, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28079507/do-micrornas-have-a-key-epigenetic-role-in-osteoarthritis-and-in-mechanotransduction
#15
REVIEW
Anna De Palma, Sara Cheleschi, Nicola Antonio Pascarelli, Sara Tenti, Mauro Galeazzi, Antonella Fioravanti
Osteoarthritis (OA) is the most common degenerative disease affecting joint tissues. The pathogenesis of OA is complex and poorly understood, as well as the multiple factors contributing to its development and progression. Accumulating evidence has suggested that microRNAs (miRNAs) play an important role as regulators of cartilage biology and in the pathogenesis of OA. It has been demonstrated that mechanical loading, important for the regulation of cartilage metabolism, affects miRNAs expression. Furthermore, miRNAs present in human plasma and in synovial fluid could represent promising biological markers for OA...
January 4, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28078394/kinematics-of-a-bicruciate-retaining-total-knee-arthroplasty
#16
Thomas J Heyse, Joshua Slane, Geert Peersman, Margo Dirckx, Arne van de Vyver, Philipp Dworschak, Susanne Fuchs-Winkelmann, Lennart Scheys
PURPOSE: The recently reintroduced bicruciate-retaining Total Knee Arthroplasty (BCR TKA) is an interesting approach in the quest for close replication of knee joint biomechanics and kinematics closer to the native knee. Therefore, this study aimed at providing a detailed biomechanical view on the functional resemblance of BCR TKA to the native knee joint. METHODS: Seven fresh-frozen full leg cadaver specimens (76 ± 10 year) were mounted in a 6 degrees-of-freedom kinematic rig that applied a dynamic squatting motion knee flexion...
January 11, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28077395/the-effects-of-posterior-cruciate-ligament-deficiency-on-posterolateral-corner-structures-under-gait-and-squat-loading-conditions-a-computational-knee-model
#17
K-T Kang, Y-G Koh, M Jung, J-H Nam, J Son, Y H Lee, S-J Kim, S-H Kim
OBJECTIVES: The aim of the current study was to analyse the effects of posterior cruciate ligament (PCL) deficiency on forces of the posterolateral corner structure and on tibiofemoral (TF) and patellofemoral (PF) contact force under dynamic-loading conditions. METHODS: A subject-specific knee model was validated using a passive flexion experiment, electromyography data, muscle activation, and previous experimental studies. The simulation was performed on the musculoskeletal models with and without PCL deficiency using a novel force-dependent kinematics method under gait- and squat-loading conditions, followed by probabilistic analysis for material uncertain to be considered...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28077394/metal-backed-versus-all-polyethylene-unicompartmental-knee-arthroplasty-proximal-tibial-strain-in-an-experimentally-validated-finite-element-model
#18
C E H Scott, M J Eaton, R W Nutton, F A Wade, S L Evans, P Pankaj
OBJECTIVES: Up to 40% of unicompartmental knee arthroplasty (UKA) revisions are performed for unexplained pain which may be caused by elevated proximal tibial bone strain. This study investigates the effect of tibial component metal backing and polyethylene thickness on bone strain in a cemented fixed-bearing medial UKA using a finite element model (FEM) validated experimentally by digital image correlation (DIC) and acoustic emission (AE). MATERIALS AND METHODS: A total of ten composite tibias implanted with all-polyethylene (AP) and metal-backed (MB) tibial components were loaded to 2500 N...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28076431/knee-cartilage-thickness-t1%C3%AF-and-t2-relaxation-time-are-related-to-articular-cartilage-loading-in-healthy-adults
#19
Sam Van Rossom, Colin Robert Smith, Lianne Zevenbergen, Darryl Gerard Thelen, Benedicte Vanwanseele, Dieter Van Assche, Ilse Jonkers
Cartilage is responsive to the loading imposed during cyclic routine activities. However, the local relation between cartilage in terms of thickness distribution and biochemical composition and the local contact pressure during walking has not been established. The objective of this study was to evaluate the relation between cartilage thickness, proteoglycan and collagen concentration in the knee joint and knee loading in terms of contact forces and pressure during walking. 3D gait analysis and MRI (3D-FSE, T1ρ relaxation time and T2 relaxation time sequence) of fifteen healthy subjects were acquired...
2017: PloS One
https://www.readbyqxmd.com/read/28075493/joint-stability-after-canine-cranial-cruciate-ligament-graft-reconstruction-varies-among-femoral-fixation-sites
#20
Louisa K Ho-Eckart, Masahiro Seki, Lindsey M Luizza, Michael T Kearney, Mandi J Lopez
OBJECTIVE: To quantify stability in cranial cruciate ligament (CrCL) deficient canine stifles with hamstring grafts affixed at 3 femoral locations. STUDY DESIGN: Canine stifle motion study using a multi-cohort, repeated measures design. SAMPLE POPULATION: 27 canine cadaver stifles. METHODS: Hamstring grafts (HG) were affixed at the gracilis-semitendinosus insertion and on the lateral femur (1) proximal trochlear ridge (TR), (2) craniodistal to fabella (F), or (3) condyle center (CC)...
January 11, 2017: Veterinary Surgery: VS
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