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Feline hypersensitivity

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https://www.readbyqxmd.com/read/27592502/a-pilot-trial-of-doxorubicin-containing-phosphatidyldiglycerol-based-thermosensitive-liposomes-in-spontaneous-feline-soft-tissue-sarcoma
#1
Katja Zimmermann, Martin Hossann, Johannes Hirschberger, Karin Troedson, Michael Peller, Moritz Schneider, Andreas Brühschwein, Andrea Meyer-Lindenberg, Gerhard Wess, Melanie Wergin, René Dörfelt, Thomas Knösel, Markus Schwaiger, Christine Baumgartner, Johanna Brandl, Sabine Schwamberger, Lars H Lindner
PURPOSE: Doxorubicin (DOX)-loaded phosphatidyldiglycerol-based thermosensitive liposomes (DPPG2-TSL-DOX) combined with local hyperthermia (HT) were evaluated in cats with locally advanced spontaneous fibrosarcomas (soft tissue sarcoma, STS). The study was designed to evaluate the safety and pharmacokinetic profile of the drug. Results from four dose-levels are reported. METHODS: Eleven client-owned cats with advanced STS were enrolled. Five cats received escalating doses of 0...
September 4, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27553477/characterization-of-the-cutaneous-mycobiota-in-healthy-and-allergic-cats-using-next-generation-sequencing
#2
Courtney Meason-Smith, Alison Diesel, Adam P Patterson, Caitlin E Older, Timothy J Johnson, Joanne M Mansell, Jan S Suchodolski, Aline Rodrigues Hoffmann
BACKGROUND: Next generation sequencing (NGS) studies have demonstrated a diverse skin-associated microbiota and microbial dysbiosis associated with atopic dermatitis in people and in dogs. The skin of cats has yet to be investigated using NGS techniques. HYPOTHESIS/OBJECTIVES: We hypothesized that the fungal microbiota of healthy feline skin would be similar to that of dogs, with a predominance of environmental fungi, and that fungal dysbiosis would be present on the skin of allergic cats...
August 23, 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/26965676/confirmatory-field-study-for-the-evaluation-of-ciclosporin-at-a-target-dose-of-7-0-mg-kg-3-2-mg-lb-in-the-control-of-feline-hypersensitivity-dermatitides
#3
Elizabeth S Roberts, Cindy Speranza, Cecilia Friberg, Craig Griffin, Jean Steffan, Linda Roycroft, Stephen King
OBJECTIVES: This study was designed to confirm the efficacy and tolerability of a daily dose of 7.0 mg/kg (3.2 mg/lb) ciclosporin in the treatment of feline hypersensitivity dermatitides (HD), as these are some of the most frequently suspected skin diseases in cats and recent publications have reported the successful use of ciclosporin in the treatment of feline HD. METHODS: In total, 217 cats with feline HD were treated q24h for 42 days with a target dose of 7 mg/kg ciclosporin (n = 144) or a placebo control (n = 73) administered either in the food or directly in the mouth following feeding...
March 10, 2016: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/26586215/an-update-on-the-treatment-of-canine-atopic-dermatitis
#4
REVIEW
Manolis N Saridomichelakis, Thierry Olivry
Canine atopic dermatitis is a common skin disease seen in veterinary clinical practice. Several factors appear to contribute to the cutaneous inflammation and pruritus. The therapeutic strategy should focus on control of those factors that can be identified and for which interventional measures are feasible; these include ectoparasites, bacterial/fungal infection and dietary hypersensitivity. Ectoparasites, particularly fleas, are not the cause of atopic dermatitis, but they are a confounding factor, which can exacerbate pruritus, and preventative measures are therefore indicated...
January 2016: Veterinary Journal
https://www.readbyqxmd.com/read/25940959/oclacitinib-in-feline-nonflea-nonfood-induced-hypersensitivity-dermatitis-results-of-a-small-prospective-pilot-study-of-client-owned-cats
#5
Christian Ortalda, Chiara Noli, Silvia Colombo, Stefano Borio
BACKGROUND: Oclacitinib is a Janus kinase inhibitor that decreases pruritus and lesions in allergic dogs. In cats, it is able to inhibit interleukin-31-induced pruritus; no information is available on its clinical effectiveness. HYPOTHESIS/OBJECTIVES: To evaluate the efficacy, ease of administration and tolerability of oclacitinib in feline nonflea-, nonfood-induced hypersensitivity dermatitis. METHODS: Cats >12 months of age and >3 kg body weight with a diagnosis of nonflea-, nonfood-induced hypersensitivity dermatitis were treated with oclacitinib, 0...
August 2015: Veterinary Dermatology
https://www.readbyqxmd.com/read/25820324/relationship-between-age-at-gonadectomy-and-health-problems-in-kittens-adopted-from-shelters
#6
RANDOMIZED CONTROLLED TRIAL
N Porters, I Polis, C P H Moons, I Van de Maele, R Ducatelle, K Goethals, L Duchateau, H de Rooster
Prepubertal gonadectomy (PPG) is promoted as a way of managing overpopulation in cats, but concerns about PPG and potential health issues still exist. The objective of the present study was to evaluate short-term and long-term health problems in cats subjected to PPG in comparison to gonadectomy at traditional age (TAG). In a prospective clinical trial, 800 shelter kittens aged between approximately 8 weeks and 12 weeks were recruited before adoption and randomly assigned to either the PPG group (gonadectomy performed immediately) or the TAG group (gonadectomy delayed until six months to eight months of age)...
May 30, 2015: Veterinary Record
https://www.readbyqxmd.com/read/25085922/endogenous-retrovirus-insertion-in-the-kit-oncogene-determines-white-and-white-spotting-in-domestic-cats
#7
Victor A David, Marilyn Menotti-Raymond, Andrea Coots Wallace, Melody Roelke, James Kehler, Robert Leighty, Eduardo Eizirik, Steven S Hannah, George Nelson, Alejandro A Schäffer, Catherine J Connelly, Stephen J O'Brien, David K Ryugo
The Dominant White locus (W) in the domestic cat demonstrates pleiotropic effects exhibiting complete penetrance for absence of coat pigmentation and incomplete penetrance for deafness and iris hypopigmentation. We performed linkage analysis using a pedigree segregating White to identify KIT (Chr. B1) as the feline W locus. Segregation and sequence analysis of the KIT gene in two pedigrees (P1 and P2) revealed the remarkable retrotransposition and evolution of a feline endogenous retrovirus (FERV1) as responsible for two distinct phenotypes of the W locus, Dominant White, and white spotting...
October 2014: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/24973320/-clinical-symptomps-diagnosis-and-therapy-of-feline-allergic-dermatitis
#8
REVIEW
C Favrot, A Rostaher, N Fischer
Allergies are often suspected in cats and they are mainly hypersensitivity reactions against insect bites, food- or environmental allergens. Cats, with non flea induced atopic dermatitis, normally present with one oft he following reaction patterns: miliary dermatitis, eosinophilic dermatitis, selfinduced alopecia or head and neck excoriations. None of these reaction patterns is nevertheless pathognomonic for allergic dermatitis, therefore the diagnosis is based on the one hand on the exclusion of similar diseases on the other hand on the successful response on a certain therapy...
July 2014: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/24829219/corticotropin-releasing-factor-family-peptide-signaling-in-feline-bladder-urothelial-cells
#9
COMPARATIVE STUDY
Ann T Hanna-Mitchell, Amanda Wolf-Johnston, James R Roppolo, Tony C A Buffington, Lori A Birder
Corticotropin-releasing factor (CRF) plays a central role in the orchestration of behavioral and neuroendocrine responses to stress. The family of CRF-related peptides (CRF and paralogs: urocortin (Ucn)-I, -II, and -III) and associated receptors (CRFR1 and CRFR2) are also expressed in peripheral tissues such as the skin and gastrointestinal tract. Local signaling may exert multiple effects of stress-induced exacerbation of many complex syndromes, including psoriasis and visceral hypersensitivity. Interstitial cystitis/painful bladder syndrome (IC/PBS), a chronic visceral pain syndrome characterized by urinary frequency, urgency, and pelvic pain, is reported to be exacerbated by stress...
July 2014: Journal of Endocrinology
https://www.readbyqxmd.com/read/24820998/effect-of-high-dose-ciclosporin-on-the-immune-response-to-primary-and-booster-vaccination-in-immunocompetent-cats
#10
Elizabeth S Roberts, Karen A VanLare, Linda M Roycroft, Stephen King
Ciclosporin (Atopica oral solution for cats 100 mg/ml; Novartis Animal Health) was recently approved for use in cats with feline hypersensitivity dermatitis. The immunosuppressant effect of ciclosporin on the ability of cats to mount an immune response following vaccination was determined. Thirty-two healthy, immunocompetent adult cats (16 cats/group) were treated with either ciclosporin for 56 days at a dose of 24 mg/kg once daily or sham dosed. Prior to treatment, cats had an adequate antibody response to primary vaccination against feline calicivirus (FCV), feline herpesvirus-1 (FHV-1), feline panleukopenia virus (FPV), feline leukemia virus (FeLV) and rabies...
February 2015: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/24820996/exploration-of-paclitaxel-taxol-as-a-treatment-for-malignant-tumors-in-cats-a-descriptive-case-series
#11
Jennifer Kim, Mary Doerr, Barbara E Kitchell
Paclitaxel, an effective chemotherapeutic agent in human oncology, has received little evaluation in feline patients. The diluent used to solubilize paclitaxel, polyoxyethylated castor oil (Cremophor EL), causes anaphylactoid reactions in human and dogs, which limits enthusiasm for use of this agent in veterinary oncology. Nine feline patients with measurable malignant tumors were treated with paclitaxel at a dosage of 80 mg/m(2) intravenously every 21 days for up to two doses. Adverse effects, including evidence of toxicity and anaphylactoid reactions, were assessed...
February 2015: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/24597491/feline-atopic-dermatitis-a-retrospective-study-of-45-cases-2001-2012
#12
Philippa A Ravens, Bei J Xu, Linda J Vogelnest
BACKGROUND: Atopic dermatitis (AD) is recognized as a common cause of pruritus in cats, but it remains incompletely characterized. HYPOTHESIS/OBJECTIVES: The aim of the study was to evaluate cases of confirmed feline AD. ANIMALS: Fourty-five cats from a dermatology referral practice (2001-2012). METHODS: A retrospective case record review was carried out using strict diagnostic criteria, including exclusion of flea-bite hypersensitivity and adverse food reaction...
April 2014: Veterinary Dermatology
https://www.readbyqxmd.com/read/24255992/carbimazole-associated-hypersensitivity-vasculitis-in-a-cat
#13
K Bowlt, I Cattin, J Stewart
Feline hyperthyroidism can be treated medically, surgically or with radioactive iodine. Carbimazole inhibits both triiodothyronine and thyroxine synthesis in the thyroid gland and reported side effects include mild eosinophilia, leucopenia and lymphocytosis, thrombocytopenia, elevated liver enzyme activities, gastrointestinal signs and skin abnormalities. This case report describes a cat with carbimazole-associated apparent hypersensitivity vasculitis causing digital and tail necrosis, with multiple renal infarcts...
December 2014: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/24147775/measurement-of-il-12-p40-p35-il-23p19-and-ifn-%C3%AE-mrna-in-duodenal-biopsies-of-cats-with-inflammatory-enteropathy
#14
N E Waly, I R Peters, M J Day, C R Stokes, M Bailey, T J Gruffydd-Jones
BACKGROUND: Dietary hypersensitivity and inflammatory bowel disease (IBD) are important causes of chronic vomiting and diarrhea in cats. IL-23 has been recently found to be a key factor in the immunopathogenesis of IBD in humans but the involvement in IBD has not been investigated in cats. HYPOTHESIS/OBJECTIVES: Expression of genes encoding Il-12p35 and p40, IL-23p19, and IFN-γ may be up-regulated in duodenal biopsy specimens taken from cats with histologic evidence of inflammation...
January 2014: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/24134659/safety-tolerability-and-pharmacokinetics-of-6-month-daily-dosing-of-an-oral-formulation-of-cyclosporine-atopica-for-cats%C3%A2-in-cats
#15
RANDOMIZED CONTROLLED TRIAL
E S Roberts, K A Vanlare, G Strehlau, M Peyrou, L M Roycroft, S King
Cyclosporine was proven efficacious in the treatment of feline hypersensitivity dermatitis. This target animal study was conducted to evaluate the safety, tolerability, and pharmacokinetics of ATOPICA for Cats® (cyclosporine oral solution, USP) MODIFIED following 6-month daily dosing in cats. Forty healthy cats (four cats/sex/group) received 0, 8 (1×), 16 (2×), 24 (3×), or 40 (5×) mg/kg cyclosporine once daily for 6 months (183 days). Body weight, food consumption, ophthalmoscopic, physical examinations including neurological assessments, blood pressure, electrocardiography, clinical pathology (hematology, coagulation, clinical chemistry, urinalysis), organ weights, and macroscopic and microscopic examinations were performed and assessed...
April 2014: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/23966004/feline-non-flea-induced-hypersensitivity-dermatitis-clinical-features-diagnosis-and-treatment
#16
Claude Favrot
PRACTICAL RELEVANCE: Hypersensitivity dermatitis (HD) is often suspected in cats and is mostly caused by insect bites, food or environmental allergens. Cats with non-flea induced HD are reported to present frequently with one or more of the following cutaneous reaction patterns: miliary dermatitis, eosinophilic dermatitis, self-induced symmetrical alopecia or head and neck excoriations/pruritus. CLINICAL CHALLENGES: None of the above patterns are, however, pathognomonic for non-flea induced HD and the diagnosis of this condition is based on exclusion of diseases presenting similarly and an adequate response to treatment...
September 2013: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/23530522/dose-tapering-for-ciclosporin-in-cats-with-nonflea-induced-hypersensitivity-dermatitis
#17
Jean Steffan, Elizabeth Roberts, Andrea Cannon, Pascal Prélaud, Peter Forsythe, Jacques Fontaine, Stephen King, Wolfgang Seewald
BACKGROUND: Little information is available on the ciclosporin dose-tapering regimen and clinical response in the treatment of feline hypersensitivity dermatitis. HYPOTHESIS/OBJECTIVES: To test a dose-tapering regimen and assess efficacy and clinical safety for up to 18 weeks. ANIMALS: Eighty-eight client-owned cats with feline hypersensitivity dermatitis. METHODS: Cats that received either a placebo or ciclosporin at 2...
June 2013: Veterinary Dermatology
https://www.readbyqxmd.com/read/23186638/feline-dermatology-at-cornell-university-1407-cases-1988-2003
#18
Danny W Scott, William H Miller, Hollis N Erb
Medical records of 1407 cats with dermatologic diagnoses made at Cornell University teaching hospital from 1988 to 2003 were tabulated. We expressed the diagnoses as counts, percentages of the cats with dermatologic disease (1407) and percentages of all cats seen at the university hospital (22,135) during the same period. A total of 1887 diagnoses were made in the 1407 cats. We compared the age, sex and breed group of our cases with all those 22,135 cats in ('1-by-c') χ(2) tests in which the hospital population was considered a standard (rather than a 'sample')...
April 2013: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/23135497/targeted-vaccines-against-feline-dander-could-be-the-cat-s-meow
#19
Megan Scudellari
No abstract text is available yet for this article.
November 2012: Nature Medicine
https://www.readbyqxmd.com/read/22900753/feline-superficial-pyoderma-a-retrospective-study-of-52-cases-2001-2011
#20
Hui W Yu, Linda J Vogelnest
BACKGROUND: Superficial pyoderma is traditionally considered rare in cats but may be more prevalent than previously reported. OBJECTIVES: To better characterize superficial pyoderma in cats. ANIMALS: Fifty-two cats from a dermatology referral population over a 10 year period. METHODS: This study was retrospective. Cases were included if neutrophils and intracellular bacteria were reported from surface cytology of skin lesions...
October 2012: Veterinary Dermatology
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