keyword
MENU ▼
Read by QxMD icon Read
search

statin veterans

keyword
https://www.readbyqxmd.com/read/28069650/evidence-to-support-continuation-of-statin-therapy-in-patients-with-staphylococcus-aureus-bacteremia
#1
Aisling R Caffrey, Tristan T Timbrook, Eunsun Noh, George Sakoulas, Steven M Opal, Victor Nizet, Kerry L LaPlante
In addition to cholesterol lowering capabilities, statins possess antiinflammatory and immunomodulatory effects. We sought to quantify the real-world impact of different statin exposure patterns on clinical outcomes in Staphylococcus aureus bacteremia. We conducted a retrospective cohort study among hospitalized patients with positive S. aureus blood cultures receiving appropriate antibiotics within 48 hours of culture collection (Veterans Affairs hospitals, 2002-2013). Three statin exposure groups were compared to non-users: pretreated statin users initiating therapy in the 30 days prior to culture and either (1) continuing statin therapy after culture, or (2) not continuing after culture, and (3) de novo users initiating at culture...
January 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27992624/association-of-perioperative-statin-use-with-mortality-and-morbidity-after-major-noncardiac-surgery
#2
Martin J London, Gregory G Schwartz, Kwan Hur, William G Henderson
Importance: The efficacy of statins in reducing perioperative cardiovascular and other organ system complications in patients undergoing noncardiac surgery remains controversial. Owing to a paucity of randomized clinical trials, analyses of large databases may facilitate informed hypothesis generation and more efficient trial design. Objective: To evaluate associations of early perioperative statin use with outcomes in a national cohort of veterans undergoing noncardiac surgery...
December 19, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27939239/reduced-cardiovascular-disease-incidence-with-a-national-lifestyle-change-program
#3
Sandra L Jackson, Sandra Safo, Lisa R Staimez, Qi Long, Mary K Rhee, Solveig A Cunningham, Darin E Olson, Anne M Tomolo, Usha Ramakrishnan, K M Venkat Narayan, Lawrence S Phillips
INTRODUCTION: Lifestyle change programs implemented within healthcare systems could reach many Americans, but their impact on cardiovascular disease (CVD) remains unclear. The MOVE! program is the largest lifestyle change program implemented in a healthcare setting in the U.S. This study aimed to determine whether MOVE! participation was associated with reduced CVD incidence. METHODS: This retrospective cohort study, analyzed in 2013-2015, used national Veterans Health Administration databases to identify MOVE! participants and eligible non-participants for comparison (2005-2012)...
December 6, 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27914506/use-of-high-intensity-statins-for-patients-with-atherosclerotic-cardiovascular-disease-in-the-veterans-affairs-health-system-practice-impact-of-the-new-cholesterol-guidelines
#4
Fatima Rodriguez, Shoutzu Lin, David J Maron, Joshua W Knowles, Salim S Virani, Paul A Heidenreich
BACKGROUND: The November 2013 American College of Cardiology/American Heart Association cholesterol guidelines recommend the use of high-intensity statins for patients with atherosclerotic cardiovascular disease (ASCVD). We sought to determine how these guidelines are being adopted at the Veterans Affairs (VA) Health System and identify treatment gaps. METHODS: We examined administrative data from the VA 12 months prior to the index dates of April 1, 2013, and after April 1, 2014, to identify patients ≤75 years of age with ≥2 codes for ASCVD...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27864237/effect-of-selected-clinical-trial-publication-on-adjunctive-nonstatin-medication-prescribing-in-the-veterans-health-administration-system
#5
Krystal S Titus-Rains, Matthew A Cantrell, Jason A Egge, Bruce Alexander, Robert F Shaw, Tami R Argo
PURPOSE: The question of whether publication of selected clinical trials is temporally followed by changes in prescribing of adjunctive lipid-lowering medications was evaluated. METHODS: In this retrospective preanalysis and postanalysis, Veterans Health Administration (VHA) patients 18 years or older who received a new or renewed order for any lipid-lowering medication between April 2, 2004, and September 2, 2014, were included. This period was chosen based on the publication dates of three trials investigating the efficacy of nonstatin medications: Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia (ENHANCE, April 3, 2008), Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus (ACCORD Lipid, March 14, 2010), and Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy (AIM-HIGH, December 15, 2011)...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27862587/are-non-allergic-drug-reactions-commonly-documented-as-medication-allergies-a-national-cohort-of-veterans-admissions-from-2000-to-2014
#6
Kevin W McConeghy, Aisling R Caffrey, Haley J Morrill, Amal N Trivedi, Kerry L LaPlante
PURPOSE: Adverse drug reactions (ADRs) including medication allergies are not well-described among large national cohorts. This study described the most common documented medication allergies and their reactions among a national cohort of Veterans Affairs (VA) inpatients. METHODS: We evaluated inpatient admissions in any VA Medical Center from 1 January 2000 to 31 December 2014. Each admission was linked with allergy history preceding or upon admission. Individual drugs were aggregated into drug class category including: penicillins, sulfonamides, angiotensin converting enzyme (ACE) inhibitors, opiates, HMG-CoA reductase inhibitors ("statins") and non-steroidal anti-inflammatory inhibitors (NSAID)...
November 13, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27829091/association-between-intensity-of-statin-therapy-and-mortality-in-patients-with-atherosclerotic-cardiovascular-disease
#7
Fatima Rodriguez, David J Maron, Joshua W Knowles, Salim S Virani, Shoutzu Lin, Paul A Heidenreich
Importance: High-intensity statin therapy is recommended for the secondary prevention of atherosclerotic cardiovascular disease (ASCVD). Nevertheless, statin therapy in general, and high-intensity statin therapy in particular, is underused in patients with established ASCVD. Objective: To determine the association between all-cause mortality and intensity of statin therapy in the Veterans Affairs health care system. Design, Setting, and Participants: A retrospective cohort analysis was conducted of patients aged 21 to 84 years with ASCVD treated in the Veterans Affairs health care system from April 1, 2013, to April 1, 2014...
January 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/27823696/comparative-effectiveness-of-outpatient-cardiovascular-disease-and-diabetes-care-delivery-between-advanced-practice-providers-and-physician-providers-in-primary-care-implications-for-care-under-the-affordable-care-act
#8
Salim S Virani, Julia M Akeroyd, David J Ramsey, Winston J Chan, Lorraine Frazier, Khurram Nasir, Suja S Rajan, Christie M Ballantyne, Laura A Petersen
BACKGROUND: The objective was to compare quality of diabetes and cardiovascular disease (CVD) care between advanced practice providers (APPs) and physicians in a primary care setting. METHODS: We identified diabetes (n=1,022,588) and CVD (n=1,187,035) patients receiving primary care between October 2013 and September 2014 in 130 Veterans Affairs facilities. We compared glycemic control (hemoglobin A1c <7%) in diabetic patients, blood pressure (BP) <140/90 mmHg in diabetic or CVD patients, cholesterol control (low-density lipoprotein cholesterol<100 mg/dL, receiving a statin) in diabetic or CVD patients, and those receiving a β-blocker (with history of myocardial infarction in the last 2 years) among patients receiving care from physicians and APPs...
November 2016: American Heart Journal
https://www.readbyqxmd.com/read/27798247/rechallenging-statin-therapy-in-veterans-with-statin-induced-myopathy-post-vitamin-d-replenishment
#9
Jenny H Kang, Quynh-Nhu Nguyen, Juleann Mutka, Quang A Le
BACKGROUND: Statins are the primary class of medications used to lower cholesterol and reduce risks for coronary heart disease. However, statin muscular adverse effects are one of the main reasons for statin nonadherence and a barrier to cardiovascular risk reduction. OBJECTIVES: The primary objective of our study was to examine the effect of replenishing vitamin D on statin-induced myopathy in veteran patients who failed to maintain statin therapy in a pharmacist-run ambulatory care setting...
October 24, 2016: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27753678/statin-drugs-decrease-progression-to-cirrhosis-in-hiv-hepatitis-c-virus-coinfected-individuals
#10
Nora T Oliver, Christine M Hartman, Jennifer R Kramer, Elizabeth Y Chiao
INTRODUCTION: Chronic HIV/hepatitis C virus (HCV) coinfection carries increased risk of cirrhosis, hepatocellular carcinoma, and death. Due to anti-inflammatory properties, 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) inhibitors (statins) may be useful adjunctive therapy to reduce liver disease progression. METHODS: Clinical information was extracted from the Veterans Affairs HIV and HCV Clinical Case Registries (1999-2010). HIV-related variables included combination antiretroviral therapy era of diagnosis, CD4 cell count, and percentage time with undetectable HIV viral load...
October 23, 2016: AIDS
https://www.readbyqxmd.com/read/27733953/predictors-of-calf-arterial-compliance-in-male-veterans-with-psychiatric-diagnoses
#11
Maju Mathew Koola, John D Sorkin, Molly Fargotstein, W Virgil Brown, Bruce Cuthbert, Jeffrey Hollis, Jeffrey K Raines, Erica J Duncan
BACKGROUND: Peripheral arterial compliance (PAC) is a measure of the ability of the vascular tree to dilate in response to a pressure wave. Reduced PAC is seen in patients with psychiatric diagnoses and has been associated with increased risk for stroke, myocardial infarction, and mortality. The objective of this pilot study was to identify predictors of reduced PAC in subjects with psychiatric diagnoses. METHODS: Male psychiatric subjects (N = 77) were studied in a cross-sectional study of medication effects on PAC conducted from August 2005 to February 2010...
2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27712783/refining-statin-prescribing-in-lower-risk-individuals-informing-risk-benefit-decisions
#12
REVIEW
Ashley Pender, Donald M Lloyd-Jones, Neil J Stone, Philip Greenland
Guidelines from the American College of Cardiology/American Heart Association, as well as those from the Veterans Affairs/Department of Defense and the Joint British Societies all recommended treating more people with statins than previous guidelines. In each guideline, the decision-making process began with an assessment of overall cardiovascular risk. Each group proposed updated treatment thresholds, and all of them lowered the threshold compared with earlier guidelines. Since release of these new guidelines in 2013 and 2014, additional evidence has emerged to suggest a rationale for extending statin consideration to an even larger proportion of asymptomatic adults-even those with a 10-year atherosclerotic cardiovascular disease risk below 7...
October 11, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27646948/statins-are-associated-with-reduced-mortality-in-multiple-myeloma
#13
Kristen Marie Sanfilippo, Jesse Keller, Brian F Gage, Suhong Luo, Tzu-Fei Wang, Gerald Moskowitz, Jason Gumbel, Brandon Blue, Katiuscia O'Brian, Kenneth R Carson
PURPOSE: The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) have activity in one of the pathways influenced by nitrogen-containing bisphosphonates, which are associated with improved survival in multiple myeloma (MM). To understand the benefit of statins in MM, we evaluated the association between statin use and mortality in a large cohort of patients with MM. PATIENTS AND METHODS: From the Veterans Administration Central Cancer Registry, we identified patients diagnosed with MM between 1999 and 2013...
September 19, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27612487/patient-and-partner-feedback-reports-to-improve-statin-medication-adherence-a-randomized-control-trial
#14
Ashok Reddy, Tiffany L Huseman, Anne Canamucio, Steven C Marcus, David A Asch, Kevin Volpp, Judith A Long
BACKGROUND: Simple nudges such as reminders and feedback reports to either a patient or a partner may facilitate improved medication adherence. OBJECTIVE: To test the impact of a pill bottle used to monitor adherence, deliver a daily alarm, and generate weekly medication adherence feedback reports on statin adherence. DESIGN: Three-month, three-arm randomized clinical trial (ClinicalTrials.gov identifier: NCT02480530). PARTICIPANTS: One hundred and twenty-six veterans with known coronary artery disease and poor adherence (medication possession ratio <80 %)...
September 9, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27553104/risk-factor-optimization-and-guideline-directed-medical-therapy-in-us-veterans-with-peripheral-arterial-and-ischemic-cerebrovascular-disease-compared-to-veterans-with-coronary-heart-disease
#15
Ravi S Hira, Jennifer B Cowart, Julia M Akeroyd, David J Ramsey, Yashashwi Pokharel, Vijay Nambi, Hani Jneid, Anita Deswal, Ali Denktas, Addison Taylor, Khurram Nasir, Christie M Ballantyne, Laura A Petersen, Salim S Virani
Cardiovascular disease (CVD) is a systemic process involving multiple vascular beds and includes coronary heart disease (CHD), ischemic cerebrovascular disease (ICVD), and peripheral arterial disease (PAD). All these manifestations are associated with an increased risk of subsequent myocardial infarction, stroke, and death. Guideline-directed medical therapy is recommended for all patients with CVD. In a cohort of US veterans, we identified 1,242,015 patients with CVD receiving care in 130 Veterans Affairs facilities from October 1, 2013 to September 30, 2014...
October 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27490640/statin-drugs-decrease-progression-to-cirrhosis-in-hiv-hcv-co-infected-individuals
#16
Nora T Oliver, Christine M Hartman, Jennifer R Kramer, Elizabeth Y Chiao
INTRODUCTION: Chronic HIV/HCV co-infection carries increased risk of cirrhosis, hepatocellular carcinoma, and death. Due to anti-inflammatory properties, HMG co-A inhibitors (statins) may be useful adjunctive therapy to reduce liver disease progression. METHODS: Clinical information was extracted from the Veterans Affairs HIV and HCV Clinical Case Registries (1999 - 2010). HIV-related variables included combination anti-retroviral therapy (cART) era of diagnosis, CD4 cell count, and percent time with undetectable HIV viral load...
August 3, 2016: AIDS
https://www.readbyqxmd.com/read/27349906/the-effect-of-a-locally-adapted-secondary-stroke-risk-factor-self-management-program-on-medication-adherence-among-veterans-with-stroke-tia
#17
Teresa M Damush, Laura Myers, Jane A Anderson, Zhangsheng Yu, Susan Ofner, Gloria Nicholas, Barbara Kimmel, Arlene A Schmid, Thomas Kent, Linda S Williams
We targeted stroke/transient ischemic attack (TIA) survivors to engage in self-management practices to manage secondary stroke risk factors. We conducted a randomized, regional pilot trial of a locally adapted, secondary stroke prevention program. We implemented the program at two Veterans Administration Medical Centers. Program sessions targeted stroke risk factor self-management. Specifically, we evaluated the effect of the program on the reach, implementation, and effectiveness on patient self-efficacy; stroke-specific, health-related quality of life; and medication adherence for the prevalent stroke risk factors: (1) diabetes, (2) hypertension, and (3) hyperlipidemia...
September 2016: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/27184399/guideline-recommended-medical-therapy-for-cardiovascular-diseases-in-the-obese-insights-from-the-veterans-affairs-clinical-assessment-reporting-and-tracking-cart-program
#18
Javier A Valle, Colin I O'Donnell, Ehrin J Armstrong, Steven M Bradley, Thomas M Maddox, P Michael Ho
BACKGROUND: Stigma against the obese is well described in health care and may contribute to disparities in medical decision-making. It is unknown whether similar disparity exists for obese patients in cardiovascular care. We evaluated the association between body mass index (BMI) and prescription of guideline-recommended medications in patients undergoing elective percutaneous coronary intervention. METHODS AND RESULTS: Using data from the Veterans Affairs Clinical Assessment, Reporting, and Tracking System Program, we identified patients undergoing elective percutaneous coronary intervention from 2007 to 2012, stratifying them by category of BMI...
May 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27154781/lipid-management-guidelines-from-the-departments-of-veteran-affairs-and-defense-a%C3%A2-critique
#19
REVIEW
Catherine S Bennet, Chanukya R Dahagam, Salim S Virani, Seth S Martin, Roger S Blumenthal, Erin D Michos, John W McEvoy
In December 2014, the US Department of Veterans Affairs and Department of Defense (VA/DoD) published an independent clinical practice guideline for the management of dyslipidemia and cardiovascular disease risk, adding to the myriad of recently published guidelines on this topic. The VA/DoD guidelines differ from major US guidelines published by the American College of Cardiology/American Heart Association in 2013 in the following ways: recommending moderate-intensity statins for the majority of patients with statin indications regardless of atherosclerotic cardiovascular disease risk; advocating for limited on-treatment lipid monitoring; and deemphasizing ancillary data, such as coronary artery calcium testing, to improve atherosclerotic cardiovascular disease risk estimation...
September 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27143663/statin-utilization-and-recommendations-among-hiv-and-hcv-infected-veterans-a-cohort-study
#20
Meredith E Clement, Lawrence P Park, Ann Marie Navar, Nwora Lance Okeke, Michael J Pencina, Pamela S Douglas, Susanna Naggie
BACKGROUND: Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections are associated with increased risk of cardiovascular disease (CVD). The potential impact of recently updated cholesterol guidelines on treatment of HIV- and HCV-infected veterans is unknown. METHODS: We performed a retrospective cohort study to assess statin use and recommendations among 13 579 HIV-infected, 169 767 HCV-infected, and 6628 HIV/HCV-coinfected male veterans aged 40-75 years...
August 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
keyword
keyword
106706
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"