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Salivary gland cancer

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https://www.readbyqxmd.com/read/29765265/is-volumetric-modulated-arc-therapy-with-constant-dose-rate-a-valid-option-in-radiation-therapy-for-head-and-neck-cancer-patients
#1
Annamaria Didona, Valentina Lancellotta, Claudio Zucchetti, Bianca Moira Panizza, Alessandro Frattegiani, Martina Iacco, Anna Concetta Di Pilato, Simonetta Saldi, Cynthia Aristei
Background: Intensity-modulated radiotherapy (IMRT) improves dose distribution in head and neck (HN) radiation therapy. Volumetric-modulated arc therapy (VMAT), a new form of IMRT, delivers radiation in single or multiple arcs, varying dose rates (VDR-VMAT) and gantry speeds, has gained considerable attention. Constant dose rate VMAT (CDR-VMAT) associated with a fixed gantry speed does not require a dedicated linear accelerator like VDR-VMAT. The present study explored the feasibility, efficiency and delivery accuracy of CDR-VMAT, by comparing it with IMRT and VDR-VMAT in treatment planning for HN cancer...
May 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29756412/adjuvant-therapy-in-major-salivary-gland-cancers-analysis-of-8580-patients-in-the-national-cancer-database
#2
Shayan Cheraghlou, Phoebe Kuo, Saral Mehra, George O Agogo, Aarti Bhatia, Zain A Husain, Wendell G Yarbrough, Barbara A Burtness, Benjamin L Judson
BACKGROUND: Evidence surrounding the effect of adjuvant treatment in salivary gland cancers is limited. The benefit of adding chemotherapy to adjuvant treatment is also of interest. We investigated the association of these treatments with survival and whether this differed by stage or the presence of adverse features. METHODS: A retrospective study of adult salivary gland cancer cases diagnosed from 2004 to 2013 in the National Cancer Data Base (NCDB) was conducted...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29752322/nccn-guidelines-insights-head-and-neck-cancers-version-1-2018
#3
A Dimitrios Colevas, Sue S Yom, David G Pfister, Sharon Spencer, David Adelstein, Douglas Adkins, David M Brizel, Barbara Burtness, Paul M Busse, Jimmy J Caudell, Anthony J Cmelak, David W Eisele, Moon Fenton, Robert L Foote, Jill Gilbert, Maura L Gillison, Robert I Haddad, Wesley L Hicks, Ying J Hitchcock, Antonio Jimeno, Debra Leizman, Ellie Maghami, Loren K Mell, Bharat B Mittal, Harlan A Pinto, John A Ridge, James Rocco, Cristina P Rodriguez, Jatin P Shah, Randal S Weber, Matthew Witek, Frank Worden, Weining Zhen, Jennifer L Burns, Susan D Darlow
The NCCN Guidelines for Head and Neck (H&N) Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are also provided for occult primary of the H&N, and separate algorithms have been developed by the panel for very advanced H&N cancers. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding evaluation and treatment of nasopharyngeal carcinoma...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29742277/development-of-a-novel-salivary-gland-cancer-lymph-node-staging-system
#4
Katri Aro, Allen S Ho, Michael Luu, Sungjin Kim, Mourad Tighiouart, Jon Mallen-St Clair, Emi J Yoshida, Stephen L Shiao, Ilmo Leivo, Zachary S Zumsteg
BACKGROUND: Current lymph node (LN) staging for salivary gland cancer (SGC) is extrapolated from mucosal head and neck squamous cell carcinoma. However, given its unique biology and clinical behavior, it is possible that a SGC-specific LN staging system would be more accurate. METHODS: Patients from the National Cancer Data Base with nonmetastatic SGC of the head and neck who were diagnosed from 2004 through 2013 and underwent surgical resection and neck dissection removing at least 10 LNs were included...
May 9, 2018: Cancer
https://www.readbyqxmd.com/read/29734861/establishment-and-characterization-of-a-carcinoma-associated-fibroblast-cell-line-derived-from-a-human-salivary-gland-adenoid-cystic-carcinoma
#5
Jing Kong, Han Zhao, Qianhui Shang, Zhifei Ma, Ni Kang, Junling Tan, Hyat Ahmed Ibrahim Alraimi, Tingjiao Liu
Salivary gland adenoid cystic carcinoma (SACC) is one of the most common malignancies in the oral and maxillofacial region. Carcinoma-associated fibroblast (CAF) is an important component in the tumor microenvironment and participates in SACC progression. In this study, we established a CAF cell line derived from a human SACC and named it CAF-SA. It was identified that CAF-SA expressed typical CAF biomarkers. Then, we studied the cellular communications between CAF-SA, tumor cells and endothelial cells. It was found that CAF-SA promoted the migration, invasion, and proliferation of SACC tumor cells in vitro...
December 2018: Cell Communication & Adhesion
https://www.readbyqxmd.com/read/29724411/submandibular-function-recovery-after-imrt-in-head-and-neck-cancer-a-prospective-dose-modelling-study
#6
Vedang Murthy, Shirley Lewis, Sadhana Kannan, Chira Ranjan Khadanga, Venkatesh Rangarajan, Kishore Joshi, Minakshi Gandhi, Sayak Dey, Ganesh Rokde, Ashwini Budrukkar, Tejpal Gupta, Sarbani Laskar, Jai Prakash Agarwal
PURPOSE: To estimate the dose response relationship for submandibular gland (SMG) recovery using salivary scintigraphy in patients diagnosed with head and neck cancer treated with curative image guided chemoradiation. MATERIAL AND METHODS: Ninety newly diagnosed head and neck cancer patients (T1-3, N0-2c, M0) treated with intensity modulated radiotherapy on a prospective clinical trial were assessed for salivary toxicity at predefined intervals using dynamic salivary scintigraphy...
April 30, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29719817/the-role-of-epstein-barr-virus-in-cervical-cancer-a-brief-update
#7
REVIEW
Semir Vranic, Farhan Sachal Cyprian, Saghir Akhtar, Ala-Eddin Al Moustafa
Epstein-Barr virus (EBV) belongs to the group of gamma-herpes viruses and was the first recognized human oncovirus. EBV is responsible for infectious mononucleosis and multiple lymphoid and epithelial malignancies including B-cell lymphomas (Burkitt lymphoma, Hodgkin lymphoma, and post-transplant lymphoproliferative disorder), various T-cell/NK lymphoproliferative disorders, nasopharyngeal carcinoma, and gastric carcinoma, respectively. In addition, the presence of EBV has been documented in other cancers including breast, prostate, oral, and salivary gland carcinomas...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29715110/human-polyomaviruses-are-not-frequently-present-in-cancer-of-the-salivary-glands
#8
Torbjörn Ramqvist, Ramona Gabriela Ursu, Linnea Haeggblom, Leila Mirzaie, Caroline Gahm, Lalle Hammarstedt-Nordenvall, Tina Dalianis, Anders Näsman
BACKGROUND/AIM: Malignant tumors of the salivary glands are rare and heterogeneous, with more than 20 subtypes, and classified mainly by histopathology. Their diagnosis is often challenging and their etiology unknown. Here, the possible association between human polyomaviruses (PyVs) and one or more salivary gland tumor subtypes was examined. MATERIALS AND METHODS: Ninety-one primary tumors, including 12 subtypes and eight corresponding metastases, were analyzed for the presence of DNA of 10 different human PyV species by a bead-based multiplex assay using polymerase chain reaction and Luminex analyses...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29708213/photoacoustic-imaging-of-tumour-vascular-permeability-with-indocyanine-green-in-a-mouse-model
#9
Kenichiro Okumura, Kotaro Yoshida, Kazuaki Yoshioka, Sho Aki, Norihide Yoneda, Dai Inoue, Azusa Kitao, Takahiro Ogi, Kazuto Kozaka, Tetsuya Minami, Wataru Koda, Satoshi Kobayashi, Yoh Takuwa, Toshifumi Gabata
Background: We analysed the haemodynamics of indocyanine green (ICG) in mouse organs and tumours and evaluated responses to anti-angiogenic agents in an allograft tumour mouse model by photoacoustic imaging. Methods: Thirty-six male mice (aged 10-14 weeks; body weight 20-25 g) were used. Real-time photoacoustic imaging of organs and tumours after intravenous injection of ICG was conducted in mice until 10 min after ICG injection. ICG distribution in tumour tissues was assessed by immunohistochemical staining and observation of ICG-derived fluorescence...
2018: European radiology experimental
https://www.readbyqxmd.com/read/29706189/risk-factors-for-salivary-gland-cancers-in-france-results-from-a-case-control-study-the-icare-study
#10
Loredana Radoï, Christine Barul, Gwenn Menvielle, Matthieu Carton, Mireille Matrat, Marie Sanchez, Corinne Pilorget, Michel Velten, Isabelle Stücker, Danièle Luce
OBJECTIVES: Epidemiological studies on the risk factors for salivary gland cancers (SGC) are rare, concern a small sample size, and show inconsistent results. The aim of the present work was to analyze several risk factors for SGC, using the data from the ICARE study, a multicenter, population-based case-control study. MATERIALS AND METHODS: Data from 73 SGC cases and 3555 controls were collected using a standardized questionnaire on lifestyle habits, personal and family medical history, and lifetime occupational history...
May 2018: Oral Oncology
https://www.readbyqxmd.com/read/29688836/pediatric-salivary-cancer-epidemiology-treatment-trends-and-association-of-treatment-modality-with-survival
#11
Elliot Morse, Rance J T Fujiwara, Zain Husain, Benjamin Judson, Saral Mehra
Objective To characterize the epidemiology of pediatric salivary cancer and associate patient, tumor, and treatment factors with treatment modality and survival. Study Design Cross-sectional analysis. Setting US national database. Subjects and Methods We identified 588 patients 19 years or younger diagnosed with salivary cancer in the National Cancer Database 2004-2013. We characterized patient, tumor, and treatment factors as proportions and associated these factors with treatment modality and overall survival via multivariable logistic regression and multivariable Cox proportional hazards regression, respectively...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29687352/an-autopsy-report-of-an-adenoid-cystic-carcinoma-arising-in-the-trachea
#12
Gargi Kapatia, Kirti Gupta, Oshan Shrestha, Anil Kumar, Ashish Bhalla
While adenoid cystic carcinoma is a common malignancy to arise within the salivary glands (21.9%) (Kokemueller et al. in Int J Oral Maxillofac Surg 33:25-31, 2004), it is seldom encountered as a tracheal mass and represents < 1% of all lung cancers. Tracheal tumors are an uncommon cause of dyspnoea due to their relatively rare occurrence (Baydur and Gottlieb in JAMA 234:829-831, 1975). They pose considerable diagnostic challenge clinically as their symptoms mimics more commoner ailments like asthma and chronic bronchitis...
April 23, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29679075/apkc%C3%AE-dependent-repression-of-yap-is-necessary-for-functional-restoration-of-irradiated-salivary-glands-with-igf-1
#13
Alejandro M Chibly, Wen Yu Wong, Maricela Pier, Hongqiang Cheng, Yongxin Mu, Ju Chen, Sourav Ghosh, Kirsten H Limesand
Xerostomia and salivary hypofunction often result as a consequence of radiation therapy for head and neck cancers, which are diagnosed in roughly 60,000 individuals every year in the U.S. Due to the lack of effective treatments for radiation-induced salivary hypofunction, stem cell-based therapies have been suggested to regenerate the irradiated salivary glands. Pharmacologically, restoration of salivary gland function has been accomplished in mice by administering IGF-1 shortly after radiation treatment, but it is not known if salivary stem and progenitor cells play a role...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669190/analysis-of-histologic-follow-up-and-risk-of-malignancy-for-salivary-gland-neoplasm-of-uncertain-malignant-potential-proposed-by-the-milan-system-for-reporting-salivary-gland-cytopathology
#14
Haiyan Liu, Clarissa Ljungren, Fan Lin, Matthew A Zarka, Longwen Chen
BACKGROUND: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. The objective of this study was to assess the risk of malignancy (ROM) of NUMP. METHODS: A retrospective analysis was conducted on 656 salivary gland fine-needle aspiration specimens from 2010 to 2016...
April 18, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29663717/salivary-gland-stem-cells-a-review-of-development-regeneration-and-cancer
#15
REVIEW
Elaine Emmerson, Sarah M Knox
Salivary glands are responsible for maintaining the health of the oral cavity and are routinely damaged by therapeutic radiation for head and neck cancer as well as by autoimmune diseases such as Sjögren's syndrome. Regenerative approaches based on the reactivation of endogenous stem cells or the transplant of exogenous stem cells hold substantial promise in restoring the structure and function of these organs to improve patient quality of life. However, these approaches have been hampered by a lack of knowledge on the identity of salivary stem cell populations and their regulators...
April 16, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29661256/main-effects-of-human-saliva-on-flavour-perception-and-the-potential-contribution-to-food-consumption
#16
Carolina Muñoz-González, Gilles Feron, Francis Canon
Whole saliva is a mixture composed by the secretions of the major and minor salivary glands and the crevicular fluid, bacteria, cells and food debris. Its properties (flow and composition) are highly intra- and inter-individually dependent and reflect the health status of individuals. Saliva plays a key role in the eating process and on the perception of flavour. Flavour corresponds to the combined effect of taste sensations, aromatics and chemical feeling factors evoked by food in the oral cavity. It is a key determinant of food consumption and intake...
April 17, 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29655708/salivary-flow-rate-after-conventional-and-intensity-modulated-radiation-therapy
#17
Caroline Tram Nguyen, Spencer Lin, Haley Clark, Allan Hovan, Jonn Wu
BACKGROUND: Conventional 3-dimensional conformal radiation therapy (3DCRT) for head and neck cancer (HNC) can cause hyposalivation, leading to caries and tooth extraction-related osteoradionecrosis. Intensity-modulated radiation therapy (IMRT) delivers more focused radiation than does 3DCRT. To reduce hyposalivation, the Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) guidelines limit salivary gland radiation dose. In this study, the authors compared the salivary flow rate in patients receiving 3DCRT and those receiving IMRT and evaluated the effect of their treatment satisfying the QUANTEC guidelines on hyposalivation...
April 11, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29622117/routine-and-advanced-diffusion-imaging-modules-of-the-salivary-glands
#18
REVIEW
Ahmed Abdel Khalek Abdel Razek
This article reviews the role of routine and advanced diffusion imaging modules of the salivary glands. Routine and advanced diffusion imaging modules have a role in differentiation of malignant from benign salivary gland tumors, characterization of some benign salivary gland tumors, and staging of salivary gland cancer. The role of advanced diffusion modules in patients with salivary gland cancer after surgery, radiation therapy, or radioiodine therapy is discussed. Advanced diffusion imaging modules can help in diagnosis and staging of Sjögren syndrome...
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29617171/lenvatinib-induced-renal-failure-two-first-time-case-reports-and-review-of-literature
#19
Stefano Cavalieri, Laura Cosmai, Augusto Genderini, Manuela Nebuloni, Antonella Tosoni, Federica Favales, Paola Pistillo, Cristiana Bergamini, Paolo Bossi, Lisa Licitra, Laura D Locati, Salvatore Alfieri
Lenvatinib (LEN) is a multi-kinase anti-angiogenic drug recently approved in several cancers. LEN is not easily manageable due to its complex safety profile. Proteinuria and renal failure (RF) were reported among the most frequent LEN-induced adverse events (AEs), often leading to discontinuations or dose modifications. Understanding the pathogenesis of these AEs could ameliorate the management of LEN-induced renal toxicity. Areas covered: We present two cases of LEN-induced renal failure (LIRF) with different pathogenesis...
April 4, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29610392/personalized-oncogenomic-analysis-of-metastatic-adenoid-cystic-carcinoma-using-whole-genome-sequencing-to-inform-clinical-decision-making
#20
Manik Chahal, Erin Pleasance, Jasleen Grewal, Eric Zhao, Tony Ng, Erin Chapman, Martin R Jones, Yaoqing Shen, Karen L Mungall, Melika Bonakdar, Gregory A Taylor, Yussanne Ma, Andrew J Mungall, Richard A Moore, Howard Lim, Daniel Renouf, Stephen Yip, Steven J M Jones, Marco A Marra, Janessa Laskin
Metastatic adenoid cystic carcinomas (ACCs) can cause significant morbidity and mortality. Because of their slow growth and relative rarity, there is limited evidence for systemic therapy regimens. Recently, molecular profiling studies have begun to reveal the genetic landscape of these poorly understood cancers, and new treatment possibilities are beginning to emerge. The objective is to use whole-genome and transcriptome sequencing and analysis to better understand the genetic alterations underlying the pathology of metastatic and rare ACCs and determine potentially actionable therapeutic targets...
April 2018: Cold Spring Harbor Molecular Case Studies
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