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Salivary gland cancer

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https://www.readbyqxmd.com/read/28079429/association-between-late-effects-assessed-by-physicians-and-quality-of-life-reported-by-head-and-neck-cancer-survivors
#1
Rikke Daugaard, Trille Kjaer, Christoffer Johansen, Jane Christiansen, Elo Andersen, Anni L Nielsen, Susanne O Dalton
BACKGROUND: Many survivors of head-and-neck cancer (HNC) suffer from late effects. Their overall quality of life deteriorates during treatment, followed by a slow recovery up to five years after treatment. We examined the association between the severity of physician-assessed late effects and the health-related quality of life (HRQoL) reported by survivors of HNC. MATERIAL AND METHODS: The analysis was based on data collected during follow-up for 136 survivors of cancer in the oral cavity, pharynx, larynx, or salivary glands...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28071626/prognostic-factors-in-postoperative-radiotherapy-in-salivary-gland-carcinoma-a-single-institution-experience-from-turkey
#2
M Kandaz, G Soydemir, Z Bahat, E Canyılmaz, A Yöney
BACKGROUND: We reviewed clinical characteristics, treatment outcomes, local and distant failure and prognostic factors in patients with salivary gland carcinoma treated with surgery and postoperative radiotherapy. MATERIALS AND METHODS: We retrospectively reviewed 75 patients with salivary gland cancer. 69 (%92) patients had cancer of the parotid gland, 3 (%4) patients had cancer of the submandibular gland and 3 (%4) patients had cancer of the minor salivary gland...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28061862/bulbar-conjunctival-metastasis-from-mucoepidermoid-carcinoma-of-parotid-a-case-report-and-review-of-literature
#3
Rajshri Yadav, Azhar J Battoo, Abdul W Mir, Altaf G Haji
BACKGROUND: Mucoepidermoid carcinoma of salivary glands usually metastasizes to the lungs, liver, bone, brain, and skin. We report a rare case of distant metastasis of high-grade mucoepidermoid carcinoma of the parotid to the ipsilateral bulbar conjunctiva of the eye. CASE PRESENTATION: Sixty-year-old male of Kashmiri origin presented to our tertiary care referral cancer institute with exophytic lesion of the left bulbar conjunctiva following his treatment for mucoepidermoid cancer of ipsilateral parotid gland, 9 months back...
January 7, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28060365/newly-described-salivary-gland-tumors
#4
Alena Skalova, Michal Michal, Roderick Hw Simpson
This review concentrates on three salivary gland tumors that have been accepted in the recent literature as new neoplastic entities: mammary analog secretory carcinoma (MASC), sclerosing polycystic adenoma (SPA) and cribriform adenocarcinoma of tongue and other minor salivary glands (CAMSGs). MASC is a distinctive low-grade malignant salivary cancer that harbors a characteristic chromosomal translocation, t(12;15) (p13;q25) resulting in an ETV6-NTRK3 fusion. SPA is a rare lesion often mistaken histologically for low-grade salivary carcinoma...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28048945/organotypic-spheroid-culture-to-mimic-radiation-induced-salivary-hypofunction
#5
H S Shin, H Y An, J S Choi, H J Kim, J Y Lim
Radiation treatment often leads to irreversible damage to normal salivary glands (SGs) because of their proximity to head and neck cancers. Optimization of the in vitro model of irradiation (IR)-induced SG damage is warranted to investigate pathophysiology and monitor treatment outcome. Here, we present an organotypic spheroid culture model to investigate the impact of IR on SGs and the mechanisms underlying IR-induced structural and functional changes. Human parotid epithelial cells were obtained from human parotid glands and plated on either plastic plates or Matrigel...
December 1, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/28048503/su-d-204-04-correlations-between-dosimetric-indices-and-follow-up-data-for-salivary-glands-six-months-after-radiation-therapy-for-head-and-neck-cancer
#6
B Chera, A Price, M Kostich, R Amdur, W Mendenhall, N Sheets, R Green, L Marks, S Das, P Mavroidis
PURPOSE: To investigate the correlation between different dosimetric indices of salivary glands (as separate or combined structures) to patient-reported dry mouth 6 months post radiotherapy using the novel patient reported outcome version of the CTCAE (PRO-CTCAE). METHODS: Forty-three patients with oropharyngeal squamous cell carcinoma were treated on a prospective multi-institutional study. All patients received de-intensified 60 Gy intensity modulated radiotherapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047022/su-g-iep2-10-lens-dose-reduction-by-patient-position-modification-during-neck-ct-exams
#7
E Mosher, J Butman, N Biassou, L Folio, C Lee
PURPOSE: Irradiation of the lens during a neck CT may increase a patient's risk of developing cataracts later in life. Radiologists and technologists at the National Institutes of Health Clinical Center (NIHCC) have developed new CT imaging protocols that include a reduction in scan range and modifying neck positioning using a head tilt. This study will evaluate the efficacy of this protocol in the reduction of lens dose. METHODS: We retrieved CT images of five male patients who had two sets of CT images: before and after the implementation of the new protocol...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039719/cytomegalovirus-induces-interleukin-6-mediated-inflammatory-response-in-salivary-gland-cancer
#8
Milena Radunovic, Nada Tomanovic, Ivana Novakovic, Ivan Boricic, Sanja Milenkovic, Milovan Dimitrijevic, Sanja Radojevic-Skodric, Ljiljana Bogdanovic, Gordana Basta-Jovanovic
PURPOSE: The purpose of this study was to examine whether cytomegalovirus (CMV) is present in different histological types of salivary gland cancer (SGC) by detecting CMV immediate-early (IE) and early gene products, and to determine the presence of its association with the overexpression of interleukin (IL)-6. METHODS: Immunohistochemical analysis of 92 cases of different histological types of SGC was performed to determine the presence of IL-6 and CMV antigen and its intensity in tumor tissue...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28039063/encapsulation-of-primary-salivary-gland-cells-in-enzymatically-degradable-poly-ethylene-glycol-hydrogels-promotes-acinar-cell-characteristics
#9
Andrew D Shubin, Timothy J Felong, Brittany E Schutrum, Debria S L Joe, Catherine E Ovitt, Danielle S W Benoit
: Radiation therapy for head and neck cancers leads to permanent xerostomia due to the loss of secretory acinar cells in the salivary glands. Regenerative treatments utilizing primary submandibular gland (SMG) cells show modest improvements in salivary secretory function, but there is limited evidence of salivary gland regeneration. We have recently shown that poly(ethylene glycol) (PEG) hydrogels can support the survival and proliferation of SMG cells as multicellular spheres in vitro...
December 27, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28028546/identification-and-characterization-of-novel-rat-polyomavirus-2-in-a-colony-of-x-scid-rats-by-p-pit-assay
#10
Lora H Rigatti, Tuna Toptan, Joseph T Newsome, Patrick S Moore, Yuan Chang
Polyomaviruses (PyVs) are known to infect a wide range of vertebrates and invertebrates and are associated with a broad spectrum of diseases, including cancers, particularly in immune-suppressed hosts. A novel polyomavirus, designated rat polyomavirus 2 (RatPyV2), was identified from a breeding colony of rats having X-linked severe combined immunodeficiency. Using a human panpolyomavirus immunohistochemistry test (P-PIT), RatPyV2 was initially detected in the parotid salivary gland of a colony member. Rolling circle amplification using DNA from harderian and parotid glands identified a novel 5...
November 2016: MSphere
https://www.readbyqxmd.com/read/28008389/immunohistochemical-expression-of-cd56-and-aldh1-in-common-salivary-gland-tumors
#11
Safoura Seifi, Maryam Seyedmajidi, Jahanshah Salehinejad, Hemmat Gholinia, Fatemeh Aliakbarpour
INTRODUCTION: Natural killer (NK) cells, of which CD56 is a specific marker, play an important role in host defense against tumors. Cancer stem cells, of which aldehyde dehydrogenase isoform 1 (ALDH1) is an immunohistochemical marker, are a group of tumorigenic cells which are involved in migration and tumor recurrences. We aimed to evaluate the expression of ALDH1 and CD56 in common salivary gland tumors, as well as their relationship with each other and with a number of clinicopathologic factors...
November 2016: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28006087/significant-and-durable-clinical-benefit-from-trastuzumab-in-2-patients-with-her2-amplified-salivary-gland-cancer-and-a-review-of-the-literature
#12
Lauren M Thorpe, Alexa B Schrock, Rachel L Erlich, Vincent A Miller, James Knost, Nguyet Le-Lindqwister, Srinivas Jujjavarapu, Siraj M Ali, Jane J Liu
BACKGROUND: Salivary ductal carcinoma and carcinoma ex pleomorphic adenoma (CEPA) are aggressive salivary gland cancers with poor prognosis. The standard of care is resection with or without radiotherapy, and there are no established systemic therapy options. METHODS: We describe 1 patient with metastatic CEPA and 1 patient with metastatic recurrent salivary duct carcinoma whose tumors were evaluated by comprehensive genomic profiling. Testing identified human epidermal growth factor receptor 2 (HER2) amplification in both patients, and an additional activating HER2 mutation in the CEPA case...
December 22, 2016: Head & Neck
https://www.readbyqxmd.com/read/28001329/fna-biopsy-of-secondary-nonlymphomatous-malignancies-in-salivary-glands-a-multi-institutional-study-of-184-cases
#13
He Wang, Raza S Hoda, William Faquin, Esther Diana Rossi, Nihar Hotchandani, Tianlin Sun, Marc Pusztaszeri, Tommaso Bizzarro, Massimo Bongiovanni, Viren Patel, Nirag Jhala, Guido Fadda, Yun Gong
BACKGROUND: Secondary malignancies of salivary glands (SMSGs) are among the most common malignant neoplasms to involve the salivary glands. Fine-needle aspiration biopsy (FNAB) of SMSG can present diagnostic challenges. The current report presents the largest such FNAB series to date. METHODS: A search of the pathology database from 6 academic institutions identified 184 FNAB cases of nonlymphomatous SMSG. RESULTS: Of the 184 cases, 171 were of the parotid glands, and 13 were of the submandibular glands; 130 patients were men, and 54 were women, and the mean patient age at diagnosis was 68 years...
December 21, 2016: Cancer
https://www.readbyqxmd.com/read/27997348/relationship-between-plasma-and-salivary-melatonin-and-cortisol-investigated-by-lc-ms-ms
#14
Martijn van Faassen, Rainer Bischoff, Ido P Kema
BACKGROUND: Disturbance of the circadian rhythm has been associated with disease states, such as metabolic disorders, depression and cancer. Quantification of the circadian markers such as melatonin and cortisol critically depend on reliable and reproducible analytical methods. Previously, melatonin and cortisol were primarily analyzed separately, mainly using immunoassays. METHODS: Here we describe the validation and application of a high-throughput liquid chromatography in combination with mass spectrometry (LC-MS/MS) method for the combined analysis of melatonin and cortisol in plasma and saliva...
December 20, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27992367/management-of-salivary-gland-carcinomas-a-review
#15
REVIEW
Xiaoli Wang, Yijun Luo, Minghuan Li, Hongjiang Yan, Mingping Sun, Tingyong Fan
Salivary gland carcinomas are a heterogeneous group of tumors with many histological subtypes which occur in both major and minor salivary glands. However, they have a relatively low of incidence. Their rarity limits study size and the ability to perform phase III trials. Therefore, to date, the entire management is usually varied. Certain published studies have paid more attention to the systemic therapy in the management of metastatic or locally recurrent salivary gland cancer, while little effort has been made to study the entire management for this lesions...
December 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27990487/tuning-hydrogel-properties-to-promote-the-assembly-of-salivary-gland-spheroids-in-3d
#16
Tugba Ozdemir, Eric W Fowler, Shuang Liu, Daniel A Harrington, Robert L Witt, Mary C Farach-Carson, Swati Pradhan-Bhatt, Xinqiao Jia
Current treatments for chronic xerostomia, or "dry mouth", do not offer long-term therapeutic benefits for head and neck cancer survivors previously treated with curative radiation. Towards the goal of creating tissue-engineered constructs for the restoration of salivary gland functions, we developed new hyaluronic acid (HA)-based hydrogels using thiolated HA (HA-SH) and acrylated HA (HA-AES) with a significant molecular weight mismatch. Four hydrogel formulations with varying HA concentration, (1-2.4 wt%) and thiol/acrylate ratios (2/1 to 36/1) and elastic moduli (G': 35 to 1897 Pa, 2 h post-mixing) were investigated...
December 12, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/27989630/-specificities-of-carcinomas-in-adolescents-and-young-adults
#17
REVIEW
Brice Fresneau, Marie-Emilie Dourthe, Anaïs Jouin, Valérie Laurence, Guénolée de Lambert, Christelle Colas, Mathilde Coret, Anne Laprie, Céleste Rebours, Daniel Orbach, Charlotte Demoor-Goldschmidt
Carcinomas are rare tumors of the adolescent-young adult (AYA) with a different spectrum from those of adults. The most common sites outside of the thyroid is the nasopharynx, salivary gland, colon-rectum and ovaries. If nasopharyngeal carcinoma or salivary gland tumors are good prognosis, others are more reserved prognosis, such as digestive carcinomas, gynecological or midline. The revelation modes are non-specific and depend on the location: mass, tumor syndrome, pain, impaired general condition. The unusual of pediatric carcinomas led to propose a systematic oncogenetic exploration...
December 15, 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27960047/incidence-and-risk-factors-of-late-recurrence-in-patients-with-salivary-gland-cancer
#18
G C Park, J-L Roh, K-J Cho, M H Jin, S-H Choi, S Y Nam, S Y Kim
OBJECTIVES: Recurrence in the late post-treatment period is relatively common in salivary gland cancer (SGC), but risk factors and survival associated with late recurrence have been rarely studied. We investigated the incidence and risk factors of SGC recurrence >5 years after treatment and associated survival. DESIGN: A retrospective cohort study. SETTING: University hospital. PARTICIPANTS: A total of 240 patients with previously untreated SGC who underwent definitive treatment...
December 13, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27943101/salivary-biomarkers-in-cancer-detection
#19
REVIEW
Xiaoqian Wang, Karolina Elżbieta Kaczor-Urbanowicz, David T W Wong
Cancer is the second most common cause of death in the USA. Its symptoms are often not specific and absent, until the tumors have already metastasized. Therefore, there is an urgent demand for developing rapid, highly accurate and noninvasive tools for cancer screening, early detection, diagnostics, staging and prognostics. Saliva as a multi-constituent oral fluid comprises secretions from the major and minor salivary glands, extensively supplied by blood. Molecules such as DNAs, RNAs, proteins, metabolites, and microbiota, present in blood, could be also found in saliva...
January 2017: Medical Oncology
https://www.readbyqxmd.com/read/27942480/diagnostic-imaging-of-benign-and-malignant-neck-masses-in-children-a-pictorial-review
#20
REVIEW
Ruth Elizabeth Brown, Srikrishna Harave
Neck masses are frequently encountered in pediatric medicine, and can present a diagnostic dilemma for the clinicians involved. There are several means by which neck masses in children can be subdivided, for example by age at presentation, anatomical location including compartments and fascia of the neck, their classical appearance when imaged, or by etiology. When imaging children the clinicians must be mindful of radiation exposure and as such ultrasound (US) is often attempted first. Cross sectional imaging can be helpful for problem solving with CT being particularly useful for assessing the patient in more acute scenarios, for example when there is airway compromise...
October 2016: Quantitative Imaging in Medicine and Surgery
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