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Salivary gland cancer

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https://www.readbyqxmd.com/read/29330972/immunohistochemical-evaluation-of-oestrogen-receptors-in-adenoid-cystic-carcinoma-of-salivary-gland
#1
Hasan Mujtaba, Muhammad Atique, Iffat Batool, Muhammad Farooq Umer
Background: Oestrogen has a physiological role throughout the body including oral cavity. The effects are mediated by binding to two receptors in nucleus alpha and beta, which are ligand-activated transcription factors. The alpha receptors have a prognostic significance in cancer of breast while in Adenoid cystic carcinoma of salivary glands the results are inconsistent. This study was conducted to determine the oestrogen receptor Alpha staining in adenoid cystic carcinoma of salivary gland...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29327681/updated-national-comprehensive-cancer-network-guidelines-for-treatment-of-head-and-neck-cancers-2010-2017
#2
Małgorzata Wierzbicka, Joanna Napierała
INTRODUCTION: The diagnostic and therapeutic recommendations have been changing over the years to improve treatment outcomes and quality of life of Head and Neck Cancer (HNC) patients. AIM: The aim of this study was to present currently recommended Head and Neck Cancer treatment guidelines based on the literature review with particular emphasis on novel approaches the NCCN algorithms. MATERIAL AND METHODS: The review of literature covering articles published in the last five years and pointing out essential changes in HNC treatment regarding evidence based medicine...
December 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29285375/expression-of-topoisomerase-ii-%C3%AE-protein-in-salivary-gland-tumors
#3
Asaf Shvero, Ohad Hilly, Golan Bubis, Yaniv Hamzany, Rumelia Koren, Lea Rath-Wolfson
Salivary glands give rise to approximately 30 histological distinct tumor types, which results in a diagnostic challenge for the pathologist. The present retrospective, immunohistochemical study aimed to evaluate the expression of Topoisomerase II-α, a nuclear enzyme, as a diagnostic and prognostic marker in benign and malignant salivary gland tumors, including leomorphic adenoma, mucoepidermoid carcinoma, acinic cell carcinoma and carcinoma ex-pleomorphic adenoma. A total of 59 cases of benign and malignant salivary gland tumors were included in the present study...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29283469/phase-ii-trial-of-eribulin-mesylate-in-recurrent-or-metastatic-salivary-gland-malignancies
#4
Cristina P Rodriguez, Renato G Martins, Christina Baik, Laura Q Chow, Rafael Santana-Davila, Bernardo H Goulart, Sylvia Lee, Keith D Eaton
BACKGROUND: This study examined the microtubule inhibitor eribulin in recurrent/metastatic salivary gland cancers (RMSGCs), a disease where no therapeutic standard exists. METHODS: This phase II clinical trial treated patients with progressive recurrent/metastatic salivary gland cancers with eribulin 1.4 mg/m2 i.v. on days 1 and 8 of a 21-day cycle until disease progression/unacceptable toxicities. The primary endpoint was the Response Evaluation Criteria in Solid Tumors (RECIST) version 1...
December 28, 2017: Head & Neck
https://www.readbyqxmd.com/read/29282901/akt3-drives-adenoid-cystic-carcinoma-development-in-salivary-glands
#5
Katalin Zboray, Julian Mohrherr, Patricia Stiedl, Klemens Pranz, Laura Wandruszka, Beatrice Grabner, Robert Eferl, Richard Moriggl, Dagmar Stoiber, Kazuhito Sakamoto, Kay-Uwe Wagner, Helmut Popper, Emilio Casanova, Herwig P Moll
Salivary gland cancer is an aggressive and painful cancer, but a rare tumor type accounting for only ~0.5% of cancer cases. Tumors of the salivary gland exhibit heterogeneous histologic and genetic features and they are subdivided into different subtypes, with adenoid cystic carcinomas (ACC) being one of the most abundant. Treatment of ACC patients is afflicted by high recurrence rates, the high potential of the tumors to metastasize, as well as the poor response of ACC to chemotherapy. A prerequisite for the development of targeted therapies is insightful genetic information for driver core cancer pathways...
December 28, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29277772/deregulation-of-nicotinamide-n-methyltransferase-and-gap-junction-protein-alpha-1-causes-metastasis-in-adenoid-cystic-carcinoma
#6
Kana Ishibashi, Kotaro Ishii, Goro Sugiyama, Tomoki Sumida, Tsuyoshi Sugiura, Y U Kamata, Katsuhiro Seki, Takahiro Fujinaga, Wataru Kumamaru, Yosuke Kobayashi, Naomi Hiyake, Hiroyuki Nakano, Tomohiro Yamada, Yoshihide Mori
BACKGROUND/AIM: Adenoid cystic carcinoma (AdCC) is a malignant tumor that occurs in the salivary glands and frequently metastasizes. The aim of this study was to identify factors mediating AdCC metastasis. MATERIALS AND METHODS: We established three AdCC cell lines by orthotropic transplantation and in vivo selection: parental, highly metastatic (ACCS-M-GFP), and lymph node metastatic (ACCS-LN-GFP) cells. RESULTS: We examined the three cell lines...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29275362/regulation-of-%C3%AE-catenin-phosphorylation-by-pr55%C3%AE-in-adenoid-cystic-carcinoma
#7
Kana Ishibashi, Kotaro Ishii, Goro Sugiyama, Y U Kamata, Azusa Suzuki, Wataru Kumamaru, Yukiko Ohyama, Hiroyuki Nakano, Tamotsu Kiyoshima, Tomoki Sumida, Tomohiro Yamada, Yoshihide Mori
BACKGROUND/AIM: Adenoid cystic carcinoma (AdCC) is a rare cancer of the salivary gland with high risk of recurrence and metastasis. Wnt signalling is critical for determining tumor grade in AdCC, as it regulates invasion and migration. β-catenin dephosphorylation plays an important role in the Wnt pathway, but its underlying molecular mechanism remains unclear. MATERIALS AND METHODS: Because the regulatory subunits of protein phosphatase 2A (PP2A) drive Wnt signalling via target molecules, including β-catenin, we used qRT-PCR and immunoblot analysis to investigate the expression of these subunits in an AdCC cell line (ACCS) and a more aggressive subline (ACCS-M)...
January 2018: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/29274153/oral-cancer-a-multicenter-study
#8
K Dhanuthai, S Rojanawatsirivej, W Thosaporn, S Kintarak, A Subarnbhesaj, M Darling, E Kryshtalskyj, C-P Chiang, H-I Shin, S-Y Choi, S-S Lee, P-A Shakib
BACKGROUND: To determine the prevalence and clinicopathologic features of the oral cancer patients. MATERIAL AND METHODS: Biopsy records of the participating institutions were reviewed for oral cancer cases diagnosed from 2005 to 2014. Demographic data and site of the lesions were collected. Sites of the lesion were subdivided into lip, tongue, floor of the mouth, gingiva, alveolar mucosa, palate, buccal/labial mucosa, maxilla and mandible. Oral cancer was subdivided into 7 categories: epithelial tumors, salivary gland tumors, hematologic tumors, bone tumors, mesenchymal tumors, odontogenic tumors, and others...
December 23, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29258258/galectins-and-carcinogenesis-their-role-in-head-and-neck-carcinomas-and-thyroid-carcinomas
#9
REVIEW
Nadège Kindt, Fabrice Journe, Ghanem E Ghanem, Sven Saussez
Head and neck cancers are among the most frequently occurring cancers worldwide. Of the molecular drivers described for these tumors, galectins play an important role via their interaction with several intracellular pathways. In this review, we will detail and discuss this role with specific reference to galectins-1, -3, and -7 in angiogenesis, cell proliferation, and invasion as well as in cell transformation and cancer progression. Furthermore, we will evaluate the prognostic value of galectin expression in head and neck cancers including those with oral cavity, salivary gland, and nasopharyngeal pathologies...
December 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29250758/refractory-facial-paralysis-a-case-report
#10
Yu-Wei Hsu, Jiunn-Tay Lee, Yi-Shu Liao, Shin Nieh, Chun-An Cheng, Chia-Kuang Tsai
PURPOSE: To present a case of salivary gland malignancy initially mimicking Bell's palsy. CASE REPORT: A 75-year-old woman with hypertension visited our neurological outpatient department,complaining of persistent right facial paralysis for more than a year after oral glucocorticoid therapy with recent development of vertigo and unsteady gait. She was previously diagnosed as having Bell's palsy and was prescribed oral glucocorticoid. However, her right facial muscles were still completely paralyzed, with no signs of improvement...
June 15, 2017: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/29242401/eboni-a-tool-for-automated-quantification-of-bone-metastasis-load-in-psma-pet-ct
#11
Jochen Hammes, Philipp Täger, Alexander Drzezga
PSMA PET/CT has a high diagnostic accuracy for lesion detection in metastatic prostate cancer (MPC), including bone metastases. Novel therapeutic approaches require valid biomarkers for standardized disease staging, progression and therapy response. Here, we introduce EBONI (Evaluation of Bone Involvement), a software to automatically quantify bone metastasis load in PSMA PET/CT. Lesion quantity, mean and maximum lesional standardized uptake value (SUV), Z-Score and percentage of affected bone volume are determined...
December 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29232247/salivary-gland-activity-obscures-mandibular-metastasis-of-prostate-carcinoma-on-68ga-prostate-specific-membrane-antigen-pet
#12
Thabo Lengana, Ismaheel Lawal, Tebatso Boshomane, Kehinde Ololade, Florette Reyneke, Chimbabantiu Kaoma, Neo Mokgoro, Mariza Vorster, Mike Sathekge
We report a case of a 65-year-old man with prostate cancer; his treatment history included radical prostatectomy followed by radiation therapy and subsequent androgen deprivation therapy for more than 5 years. He currently presented with a history of rising prostate-specific antigen and complained of jaw aches. Ga-prostate-specific membrane antigen PET/CT study performed for suspected biochemical recurrence demonstrated vertebral lesions and lesion in his jaw. Subsequent biopsy of jaw lesion demonstrated prostate cancer metastases...
February 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29216393/monte-carlo-simulation-of-out-of-field-organ-doses-and-cancer-risk-in-tanzania-for-radiation-therapy-of-unilateral-retinoblastoma-using-a-60co-unit
#13
Suleiman Ameir Suleiman, Yaping Qi, Yifei Pi, X George Xu
The use of 60Co teletherapy unit for the treatment of unilateral retinoblastoma (Rb) patients is a very common procedure in many developing countries including Tanzania. The aim of this study was to estimate organ-specific absorbed doses from an external beam radiation therapy 60Co unit for unilateral Rb and to assess the risks of the patients developing a secondary primary cancer. The absorbed dose estimations were based on a Monte Carlo method and a set of age-dependent computational male phantoms. The estimated doses were used to calculate the secondary cancer risks in out-of-field organs using the Biological Effects of Ionising Radiation VII risk models...
December 5, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29209436/the-potential-relationship-between-flammer-and-sj%C3%A3-gren-syndromes-the-chime-of-dysfunction
#14
REVIEW
Babak Baban, Olga Golubnitschaja
Flammer syndrome (FS) is a term to blanket a cluster of vascular and nonvascular signs and symptoms linked to primary vascular dysregulation (PVD), increased sensitivity to various stimuli (stress, drugs, etc.) and altered sense regulation such as pain, smell and thirst perception. On one hand, disruption of blood barrier and homeostasis of the body are the main targets of vascular irregularity. Inflammation and immune disorders including autoimmunity are considered as a consequence of the abnormal vascular regulation processes...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29207199/genes-and-pathways-associated-with-the-occurrence-of-malignancy-in-benign-lymphoepithelial-lesions
#15
Yao Mawulikplimi Adzavon, Pengxiang Zhao, Xin Zhang, Mengyu Liu, Baobei Lv, Linqi Yang, Xujuan Zhang, Fei Xie, Mingzi Zhang, Jianmin Ma, Xuemei Ma
There is increasing evidence concerning the occurrence of malignant lymphoma among people suffering from Mikulicz disease, also termed benign lymphoepithelial lesion (BLEL) and immunoglobulin G4‑associated disease. However, the underlying molecular mechanism of the malignant transformation remains unclear. The present study aimed to investigate the gene expression profile between BLEL and malignant lymphoepithelial lesion (MLEL) conditions using tissue microarray analysis, to identify genes and pathways which may be associated with the risk of malignant transformation...
November 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29204340/evaluation-of-coexistence-of-cancer-and-active-tuberculosis-16-case-series
#16
Beyhan Çakar, Aydın Çiledağ
Introduction: Tuberculosis is an important risk factor for cancer. Pulmonary TB and lung cancer(LC) may mimic each other especially in the aspect of the clinical and radiological features. The aim of the study was to evaluate the features and risk factors of cases with coexistence cancer and active TB. Methodology: We retrospectively reviewed the medical records of patients with coexisting TB and cancer a period from 2009 to 2014. We evaluated demographic data, the ways diagnosis of TB cases, the location of TB and cancer, TB treatment results of the cases...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29192740/bilateral-parotid-gland-metastases-from-gastric-signet-ring-cell-carcinoma
#17
Federico Nichetti, Federica Morano, Alessandra Fabbri, Filippo de Braud, Maria Di Bartolomeo
INTRODUCTION: Signet-ring cell (SRC) carcinoma is a common subtype of gastric adenocarcinoma associated with poor prognosis. Metastatic involvement of the parotid gland has been reported in gastric cancer patients, but never bilaterally nor in association with the SRC histotype. Here, we report the first case and a brief review of the literature. CASE DESCRIPTION: A 47-year-old woman was referred to our center for a signet-ring gastric carcinoma with synchronous hepatic and peritoneal metastases...
November 22, 2017: Tumori
https://www.readbyqxmd.com/read/29173756/proton-therapy-for-head-and-neck-cancers
#18
REVIEW
Pierre Blanchard, Gary Brandon Gunn, Alexander Lin, Robert L Foote, Nancy Y Lee, Steven J Frank
Because of its sharp lateral penumbra and steep distal fall-off, proton therapy offers dosimetric advantages over photon therapy. In head and neck cancer, proton therapy has been used for decades in the treatment of skull-base tumors. In recent years the use of proton therapy has been extended to numerous other disease sites, including nasopharynx, oropharynx, nasal cavity and paranasal sinuses, periorbital tumors, skin, and salivary gland, or to reirradiation. The aim of this review is to present the physical properties and dosimetric benefit of proton therapy over advanced photon therapy; to summarize the clinical benefit described for each disease site; and to discuss issues of patient selection and cost-effectiveness...
January 2018: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/29172327/head-and-neck-cancer-patients-%C3%A2-information-for-the-general-dental-practitioner
#19
Jennifer Noone, Craig Barclay
Salivary gland damage is the most common adverse effect associated with radiation therapy to the head and neck. A combination of hyposalivation and dietary changes, with a reduced emphasis on oral hygiene practices can contribute to a massive increase in a person’s caries risk status. This can be further complicated by limited mouth opening. To enable optimal dental care for head and neck cancer patients before, during and after radiation therapy, patients must be informed and educated about the potential risks of dental caries and the preventive strategies available...
March 2017: Dental Update
https://www.readbyqxmd.com/read/29163848/radiation-therapy-and-serum-salivary-amylase-in-head-and-neck-cancer
#20
REVIEW
Francesca De Felice, Mario Tombolini, Angela Musella, Francesco Marampon, Vincenzo Tombolini, Daniela Musio
Radiation therapy (RT) is a valid treatment option for head and neck cancer (HNC). The risk of RT-induced toxicities is significant, especially due to extended treatment fields. The raise in amylase activity is strictly dependent on the volume of salivary glands included in the irradiated target volume and it is firmly related to the dose. The aim of this review is to report the effects on salivary amylase activity after radiation exposure of salivary glands, in patients with HNC.
October 27, 2017: Oncotarget
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