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Atrial fibrilation

Tomasz Jasiński, Radosław Owczuk, Magdalena Wujtewicz
BACKGROUND: Salbutamol is a short acting beta-2 mimetic commonly used among intensive care unit patients. There are data suggesting that his mechanism of action can be a potential factor triggering arrhythmias. The aim of this study was to assess whether nebulized salbutamol causes systemic effects resulting in electrocardiographic alterations associated with atrial fibrillation occurrence in mechanically ventilated patients. METHODS: 50 individuals were randomly allocated to receive either 2...
September 22, 2018: Anaesthesiology Intensive Therapy
José Luis Ibáñez, Alicia Ibáñez, Teresa Barrio, Mercedes Ortiz, Raquel Ajo, Eduardo Castellanos, Santiago Heras, Thomas Brouzet, Jessica Sánchez, María Ajo, Enrique Garcia, Juan Gabriel Martínez, Francisco Sogorb, Jesús Almendral
PURPOSE: Ablation of atrioventricular (AV) conduction and pacemaker implantation is the therapy of last resort for symptomatic atrial tachyarrythmias when rhythm and rate control fail, but is far from ideal. To evaluate whether interatrial electrical disconnection as a result of catheter ablation is feasible and of potential clinical utility as a means of non-pharmacological heart rate control. METHODS: Eleven patients with medically refractory atrial fibrillation or left atrial flutter and symptomatic rapid ventricular response were included...
September 21, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Caijie Shen, Bin Kong, Yu Liu, Liang Xiong, Wei Shuai, Guangji Wang, Dajun Quan, He Huang
Recent years, the role of long non-coding RNAs (lncRNAs) in atrial fibrillation (AF) has been gradually elucidated. In the current study, we measured the expression of ten AF-related lncRNAs to do qRT-PCR analysis. LncRNA KCNQ1 overlapping transcript 1 (KCNQ1OT1) was found to be significantly upregulated in AF model and Ang-II-induced mice heart. CACNA1C has been reported as a biomarker in atrial fibrillation. Here, we found that the expression pattern of CACNA1C was consistent with that of KCNQ1OT1. Electrophysiological study was conducted to demonstrate the effect of KCNQ1OT1 and CACNA1C on the Effective refractory period (ERP), interatrial conduction time (IACT), incidence of AF and AF duration of Ang-II-induced mice heart...
September 18, 2018: Biochemical and Biophysical Research Communications
Joris R de Groot
No abstract text is available yet for this article.
September 18, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Ameenathul Fawzy, Gregory Y H Lip
No abstract text is available yet for this article.
September 18, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Basel Ramlawi, Kareem Bedeir, James R Edgerton
The left atrial appendage (LAA) is a major site of clot formation in atrial fibrillation. Stand-alone thoracoscopic LAA complete closure can decrease stroke risk and may be an alternative to life-long oral anticoagulation.1 We describe our technique for totally thoracoscopic LAA exclusion with an epicardial clip device. This approach provides a safe and likely more effective alternative to LAA management than other endocardial devices.
September 18, 2018: Annals of Thoracic Surgery
Adam Ioannou, Nikolaos Papageorgiou, Donald Singer, Constantinos G Missouris
Background: Cardiovascular disease is the leading cause of morbidity and mortality in developed countries. Many patients do not experience symptoms before a first major cardiovascular event. Resting electrocardiogram (ECG) may help identify asymptomatic individuals with a high risk of cardiovascular disease. Objective: We sought to determine the prevalence of ECG abnormalities in an apparently symptom-free adult population within a prospective registry. Methods: The registry consisted of 4739 consecutive apparently healthy individuals (age 62...
September 20, 2018: QJM: Monthly Journal of the Association of Physicians
Dolkun Rahmutula, Hao Zhang, Emily E Wilson, Jeffrey E Olgin
Aims: TGF-ß1 plays an important role in atrial fibrosis and atrial fibrillation (AF); previous studies have shown that the atria are more susceptible to TGF-ß1 mediated fibrosis than the ventricles. Natriuretic peptides play an important role in cardiac remodeling and fibrosis, but the role of natriuretic peptide clearance receptor (NPR-C) is largely unknown. We investigated the role of NPR-C in modulating TGF-ß1 signaling in the atria. Methods and results: MHC-TGF-ß1 transgenic mice (TGF-ß1-Tx), which develop isolated atrial fibrosis and AF, were cross-bred with NPR-C knock-out mice (NPR-C-KO)...
September 18, 2018: Cardiovascular Research
Rebecca Bei Jia Cui, Kheng-Seong Ng, Christopher J Young
BACKGROUND: Postoperative hemorrhage and thromboembolism are recognized complications following colorectal and abdominal wall surgery, but accurate documentation of their incidence, trends, and outcomes is scant. This is relevant given the increasing number of surgical patients with cardiovascular comorbidity on anticoagulant/antiplatelet therapy. OBJECTIVE: This study aims to characterize trends in the use of anticoagulant/antiplatelet therapy among patients undergoing major colorectal and abdominal wall surgery within the past decade, and to assess rates of, outcomes following, and risk factors for hemorrhagic and thromboembolic complications...
September 19, 2018: Diseases of the Colon and Rectum
Bin Wang, Yusheng Xue, Fujun Shang, Sifeng Ni, Xiongtao Liu, Boyuan Fan, Haichang Wang
OBJECTIVE: Adropin, a newly identified regulatory protein encoded by Enho gene, suppressed tumor necrosis factor α-induced THP1 monocyte adhesion to human umbilical vein endothelial cells. In addition, inflammation is demonstrated to be involved in the mechanism of atrial fibrillation (AF). Atrial remodeling is correlated with the persistence and progression of AF. Adropin is hypothesized to correlated with AF and atrial remodeling. This study aims to determine the correlation of serum adropin and the presence of AF and remodeling...
September 21, 2018: Journal of Clinical Laboratory Analysis
Mounir Bouame, Mohamed Ali Lahmar, Mohamed Tahar Bouafia, Naima Hammoudi, Mohamed Tayeb Chentir, Mouloud Ait Athmane, Saïd Kara, Matthieu Trancart, Yildiz Levent, Jerome Cheynel, Redouane Soualmi
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia, with substantial public health and economic impact on healthcare systems due to the prevention and management of thromboembolic and hemorrhagic complications. In Algeria, stroke is a leading cause of death, representing 15.6% of all deaths in 2012. Current data on the epidemiology and costs associated with non-valvular AF (NVAF) in Algeria are not available. METHODS: A three-step approach was undertaken to estimate the economic burden of NVAF in Algeria...
September 21, 2018: Journal of Medical Economics
Ahmed AlTurki
No abstract text is available yet for this article.
October 2018: Korean Circulation Journal
Sefa Okar, Onur Kaypakli, Durmuş Yıldıray Şahin, Mevlüt Koç
BACKGROUND AND OBJECTIVES: We aimed to investigate the relationship between the recurrence of atrial fibrillation (AF) and fibrosis marker soluble ST2 (sST2) in patients with nonvalvular paroxysmal AF (PAF). METHODS: We prospectively included 100 consecutive patients with PAF diagnosis and scheduled for cryoballoon catheter ablation for AF (47 males, 53 females; mean age 55.1±10.8 years). sST2 plasma levels were determined using the ASPECT-PLUS assay on ASPECT Reader device (Critical Diagnostics)...
October 2018: Korean Circulation Journal
Avi Sabbag, Xiaoxi Yao, Konstantinos C Siontis, Peter A Noseworthy
The burden of atrial fibrillation (AF) is projected to increase substantially over the next decade in parallel with the aging of the population. The increasing age, level of comorbidity, and polypharmacy will complicate the treatment of older adults with AF. For instance, advanced age and chronic kidney disease have been shown to increase the risk of both thromboembolism and bleeding in patients with AF. Frailty, recurrent falls and polypharmacy, while very common among elderly patients with AF, are often overlooked in the clinical decision making despite their significant interaction with oral anticoagulant (OAC) and profound impact on the patient's clinical outcomes...
October 2018: Korean Circulation Journal
Gerrit Frommeyer, Jan Weller, Christian Ellermann, Patrick Leitz, Simon Kochhäuser, Philipp S Lange, Dirk G Dechering, Lars Eckardt
Ivabradine has recently been demonstrated to have antiarrhythmic properties in atrial fibrillation. The aim of the present study was to assess the electrophysiologic profile of ivabradine in an experimental whole-heart model of long-QT-syndrome. In 12 isolated rabbit hearts long-QT-2-syndrome (LQT2) was simulated by infusion of D,L-sotalol (100 µM). 12 rabbit hearts were treated with veratridine (0.5 µM) to mimic long-QT-3-syndrome (LQT3). Sotalol induced a significant prolongation of QT-interval (+ 40 ms, p < 0...
September 20, 2018: Cardiovascular Toxicology
Junichiro Miake, Masaru Kato, Kazuyoshi Ogura, Kazuhiko Iitsuka, Akihiro Okamura, Takuya Tomomori, Daiki Tsujimoto, Masahiko Kato, Kazuhiro Yamamoto
Association between pre-ablation levels of biomarkers of cardiac and endothelial dysfunctions, CHADS2, CHA2DS2-VASc, and APPLE scores and the recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation has not been fully studied. A total of 254 patients with nonvalvular AF were prospectively followed for AF recurrence after a single ablation procedure. During a two-year follow-up period, AF recurred in 65 (25.6%) patients. Patients with AF recurrence had significantly greater baseline ln brain natriuretic peptide (BNP) than those without AF recurrence (P < 0...
September 20, 2018: Heart and Vessels
Henry Sutanto, Dobromir Dobrev, Jordi Heijman
No abstract text is available yet for this article.
September 20, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
Chi-Jen Weng, Cheng-Hung Li, Ying-Chieh Liao, Che-Chen Lin, Jiunn-Cherng Lin, Shih-Lin Chang, Chu-Pin Lo, Kuo-Ching Huang, Jin-Long Huang, Ching-Heng Lin, Yu-Cheng Hsieh, Tsu-Juey Wu
The data relates to the cohort of patients with atrial fibrillation (AF) from the National Health Insurance Research Database of Taiwan, "Rhythm Control Better Prevents Stroke and Mortality than Rate Control Strategies in Patients with Atrial Fibrillation - A Nationwide Cohort Study" (Weng et al., in press). The AF patients might receive either rate or rhythm control strategy according to the medication used. The baseline medication in rate and rhythm control groups was included in this dataset. Multivariate Cox hazards regression model was used to evaluate the hazard ratio (HR) for major adverse cardiovascular events (MACE), including ischemic/hemorrhagic stroke and mortality in AF patients receiving rate or rhythm control...
October 2018: Data in Brief
David Vidmar, Mahmood I Alhusseini, Sanjiv M Narayan, Wouter-Jan Rappel
Objective: Determining accurate intracardiac maps of atrial fibrillation (AF) in humans can be difficult, owing primarily to various sources of contamination in electrogram signals. The goal of this study is to develop a measure for signal fidelity and to develop methods to quantify robustness of observed rotational activity in phase maps subject to signal contamination. Methods: We identified rotational activity in phase maps of human persistent AF using the Hilbert transform of sinusoidally recomposed signals, where localized ablation at rotational sites terminated fibrillation...
2018: Frontiers in Physiology
Eyob Alemayehu Gebreyohannes, Akshaya Srikanth Bhagavathula, Henok Getachew Tegegn
Background: Atrial fibrillation (AF) is a major risk factor for stroke as it increases the incidence of stroke nearly fivefold. Antithrombotic treatment is recommended for the prevention of stroke in AF patients. However, majorly due to fear of risk of bleeding, adherence to recommendations is not observed. The aim of this study was to investigate the impact of antithrombotic undertreatment, on ischemic stroke and/or all-cause mortality in patients with AF. Methods: A retrospective cohort study was conducted from January 7, 2017 to April 30 2017 using medical records of patients with AF attending Gondar University Hospital (GUH) between November 2012 and September 2016...
2018: Thrombosis Journal
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