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Susanne Brakemeier, Lars Vogt, Lisa Adams, Bianca Zukunft, Gerd Diederichs, Bernd Hamm, Klemens Budde, Marcus R Makowski
PURPOSE: Tuberous sclerosis complex (TSC)-associated renal angiomyolipoma (AML) have a high lifetime risk of acute bleeding. MTOR-inhibitors are a promising novel treatment for TSC-AML, however adequate response to therapy can be difficult to assess. Early changes in MRI signal may serve as a novel early indicator for a satisfactory response to mTOR-inhibitor therapy of AML. MATERIALS AND METHODS: Thirty-eight patients with the definite diagnosis of tuberous sclerosis receiving everolimus therapy and n = 19 patients without specific therapy were included...
2017: PloS One
Orly L Levit, Veronika Shabanova, Alia Bazzy-Asaad, Matthew J Bizzarro, Vineet Bhandari
AIM: To identify variables that affect the risk of tracheostomy in a population of extremely low birth weight (ELBW) infants. METHODS: A retrospective matched case-control study was conducted. ELBW infants with a tracheostomy were compared with controls without tracheostomy. Data collection included demographics, detailed information about each intubation and extubation attempt, the use of steroids and the presence of comorbidities. Statistical analyses include conditional logistic regression and Poisson regression for clustered observations...
February 21, 2017: Journal of Maternal-fetal & Neonatal Medicine
Zatollah Asemi, Mansooreh Samimi, Mehrnush Amiri Siavashani, Maryam Mazloomi, Zohreh Tabassi, Maryam Karamali, Mehri Jamilian, Ahmad Esmaillzadeh
BACKGROUND: Pregnancy is associated with unfavorable metabolic profile, which might in turn result in adverse pregnancy outcomes. The current study was designed to evaluate the effects of calcium plus Vitamin D administration on metabolic status and pregnancy outcomes in healthy pregnant women. METHODS: This randomized double-blind placebo-controlled clinical trial was performed among 42 pregnant women aged 18-40 years who were at week 25 of gestation. Subjects were randomly allocated to consume either 500 mg calcium-200 IU cholecalciferol supplements (n = 21) or placebo (n = 21) for 9 weeks...
2016: International Journal of Preventive Medicine
André Hennigs, Valerie Fuchs, Hans-Peter Sinn, Fabian Riedel, Geraldine Rauch, Katharina Smetanay, Michael Golatta, Christoph Domschke, Florian Schuetz, Andreas Schneeweiss, Christof Sohn, Joerg Heil
PURPOSE: To explore whether patients after a reexcision due to involved or close margins have the same risk of local recurrence (LR) than those after a one-step breast-conserving surgery (BCS); to learn whether the presence of residual cancer in the reexcision specimen influences the probability of LR. METHODS: We reviewed demographic, clinical, radiologic, and pathologic records of a cohort of women diagnosed with invasive cancer or carcinoma-in situ who underwent BCS surgery as final surgical treatment between January 1, 2003, and December 31, 2011...
June 2016: Annals of Surgical Oncology
Amie Y Lee, Laura Ichikawa, Janie M Lee, Christoph I Lee, Wendy B DeMartini, Bonnie N Joe, Karen J Wernli, Brian L Sprague, Sally D Herschorn, Constance D Lehman
OBJECTIVE: The purpose of this study was to evaluate concordance between BI-RADS assessments and management recommendations for breast MRI in community practice. MATERIALS AND METHODS: Breast MRI data were collected from four regional Breast Cancer Surveillance Consortium registries from 2005 to 2011 for women who were 18-79 years old. Assessments and recommendations were compared to determine concordance according to BI-RADS guidelines. Concordance was compared by assessment category as well as by year of examination and clinical indication...
January 2016: AJR. American Journal of Roentgenology
Thomas W Frazier, Eric A Youngstrom, Antonio Y Hardan, Stelios Georgiades, John N Constantino, Charis Eng
BACKGROUND: Previous studies have demonstrated aggregation of autistic traits in undiagnosed family members of children with autism spectrum disorder (ASD), which has significant implications for ASD risk in their offspring. This study capitalizes upon a large, quantitatively characterized clinical-epidemiologic family sample to establish the extent to which family transmission pattern and sex modulate ASD trait aggregation. METHODS: Data were analyzed from 5515 siblings (2657 non-ASD and 2858 ASD) included in the Interactive Autism Network...
2015: Molecular Autism
Meera N Harhay, Michael O Harhay, Fernando Coto-Yglesias, Luis Rosero Bixby
OBJECTIVES: Recent studies in Central America indicate that mortality attributable to chronic kidney disease (CKD) is rising rapidly. We sought to determine the prevalence and regional variation of CKD and the relationship of biologic and socio-economic factors to CKD risk in the older-adult population of Costa Rica. METHODS: We used data from the Costa Rican Longevity and Health Aging Study (CRELES). The cohort was comprised of 2657 adults born before 1946 in Costa Rica, chosen through a sampling algorithm to represent the national population of Costa Ricans >60 years of age...
January 2016: Tropical Medicine & International Health: TM & IH
Joshua S Ng-Kamstra, Sarah L M Greenberg, Meera Kotagal, Charlotta L Palmqvist, Francis Y X Lai, Rishitha Bollam, John G Meara, Russell L Gruen
BACKGROUND: Aggregate and risk-stratified perioperative mortality rates (POMR) are well-documented in high-income countries where surgical databases are common. In many low-income and middle-income country (LMIC) settings, such data are unavailable, compromising efforts to understand and improve surgical outcomes. We undertook a systematic review to determine how POMR is used and defined in LMICs and to inform baseline rates. METHODS: We searched PubMed for all articles published between Jan 1, 2009, and Sept 1, 2014, reporting surgical mortality in LMICs...
April 27, 2015: Lancet
Qiang Lin, Huodong Zhou, Dafeng Li, Jinfeng Ye, Jinfu Hong, Yemao Hu
OBJECTIVE: To assess the effect of perioperative goal-directed fluid therapy (GDFT) on clinical outcomes in elective colorectal resection. METHODS: A total of 42 patients undergoing elective colorectal resection between March 2013 and December 2014 were recruited prospectively. GDFT was administrated based on corrected left ventricular ejection time and stroke volume using the esophageal Doppler monitoring. These patients were compared with a historical cohort of 58 patients managed without GDFT from January 2012 to February 2013...
July 2015: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Harry Bartelink, Philippe Maingon, Philip Poortmans, Caroline Weltens, Alain Fourquet, Jos Jager, Dominic Schinagl, Bing Oei, Carla Rodenhuis, Jean-Claude Horiot, Henk Struikmans, Erik Van Limbergen, Youlia Kirova, Paula Elkhuizen, Rudolf Bongartz, Raymond Miralbell, David Morgan, Jean-Bernard Dubois, Vincent Remouchamps, René-Olivier Mirimanoff, Sandra Collette, Laurence Collette
BACKGROUND: Since the introduction of breast-conserving treatment, various radiation doses after lumpectomy have been used. In a phase 3 randomised controlled trial, we investigated the effect of a radiation boost of 16 Gy on overall survival, local control, and fibrosis for patients with stage I and II breast cancer who underwent breast-conserving treatment compared with patients who received no boost. Here, we present the 20-year follow-up results. METHODS: Patients with microscopically complete excision for invasive disease followed by whole-breast irradiation of 50 Gy in 5 weeks were centrally randomised (1:1) with a minimisation algorithm to receive 16 Gy boost or no boost, with minimisation for age, menopausal status, presence of extensive ductal carcinoma in situ, clinical tumour size, nodal status, and institution...
January 2015: Lancet Oncology
Mariana Guenther, Moacyr Araújo, Manuel Flores-Montes, Eliane Gonzalez-Rodriguez, Sigrid Neumann-Leitão
Size-fractioned phytoplankton (pico, nano and microplankton) biomass and production were estimated throughout a year at Recife harbor (NE Brazil), a shallow well mixed tropical hypereutrophic estuary with short residence times but restricted water renewal. Intense loads of P-PO4 (maximum 14 μM) resulted in low N:P ratios (around 2:1), high phytoplankton biomass (B=7.1-72 μg chl-a L(-1)), production (PP=10-2657 μg C L(-1) h(-1)) and photosynthetic efficiency (P(B)=0.5-45 μg C μg chl-a(-1)), but no oxygen depletion (average O2 saturation: 109...
February 28, 2015: Marine Pollution Bulletin
Joanna Thomson, Lilliam Ambroggio, Eileen Murtagh Kurowski, Angela Statile, Camille Graham, Joshua D Courter, Brieanne Sheehan, Srikant Iyer, Christine M White, Samir S Shah
BACKGROUND: Recent national guidelines recommend use of narrow-spectrum antibiotic therapy as empiric treatment for children hospitalized with community-acquired pneumonia (CAP). However, clinical outcomes associated with adoption of this recommendation have not been studied. METHODS: This retrospective cohort study included children age 3 months to 18 years, hospitalized with CAP from May 2, 2011 through July 30, 2012. Primary exposure of interest was empiric antibiotic therapy, classified as guideline recommended or not...
January 2015: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
Shinya Neri, Junji Yoshida, Genichiro Ishii, Yuki Matsumura, Keiju Aokage, Tomoyuki Hishida, Kanji Nagai
OBJECTIVE: We aimed to assess the prognostic significance of microscopic vessel invasion (MVI) and visceral pleural invasion (VPI) in non-small cell lung cancer (NSCLC). BACKGROUND: VPI is included in the current tumor-node-metastasis (TNM) classification in NSCLC; however, MVI is not incorporated in TNM classification. METHODS: From August 1992 to December 2009, 2657 consecutive patients with pathological T1-4N0-2M0 NSCLC underwent complete resection...
August 2014: Annals of Surgery
Yon Su Kim, Han Soo Kim, Ha Young Oh, Moon-Kyu Lee, Cheol Ho Kim, Yong Soo Kim, David Wu, Amy O Johnson-Levonas, Byung-Hee Oh
Microalbuminuria is an early sign of nephropathy and an independent predictor of end-stage renal disease. The purpose of this study was to assess microalbuminuria prevalence and its contributing factors in Korean hypertensive patients. This cross-sectional study enrolled male and female patients of ≥35 years old with an essential hypertension diagnosis as made by 841 physicians in primary care clinics and 17 in general hospitals in the Republic of Korea between November 2008 and July 2009. To assess microalbuminuria prevalence, urine albumin/creatinine ratio (UACR) was measured in patients with a positive dipstick test...
September 2013: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Rebecca Troisi, Marianne Hyer, Elizabeth E Hatch, Linda Titus-Ernstoff, Julie R Palmer, William C Strohsnitter, Arthur L Herbst, Ervin Adam, Robert N Hoover
BACKGROUND: Diethylstilbestrol (DES), a synthetic estrogen that was used in pregnancy, is a prototype endocrine-disrupting chemical. Although prenatal exposure to DES is known to increase risks of vaginal/cervical adenocarcinoma and adverse reproductive outcomes in women, and urogenital anomalies in men, data on nonreproductive medical conditions are lacking. METHODS: We estimated hazard ratios and their associated 95% confidence intervals for the associations between prenatal DES exposure and the occurrence of cardiovascular disease, diabetes, osteoporosis, and related conditions among 5590 female and 2657 male offspring followed from 1994 through 2006, adjusted for birth year, cohort, sex, body mass index, smoking status, alcohol use, education, and number of general physical examinations in the past 5 years...
May 2013: Epidemiology
Hannah Gardener, Tatjana Rundek, Clinton B Wright, Mitchell S V Elkind, Ralph L Sacco
BACKGROUND AND PURPOSE: The American Heart Association recommends limiting sodium intake to ≤ 1500 mg/day for ideal cardiovascular health. Although sodium intake has been linked to vascular disease by direct relationship with hypertension, few studies have supported an association with stroke risk. METHODS: Participants were from the Northern Manhattan Study (mean age 69 ± 10 years, 64% women, 21% white, 53% Hispanic, 24% black), a population-based cohort study of stroke incidence...
May 2012: Stroke; a Journal of Cerebral Circulation
David H Miller, Thomas Weber, Richard Grove, Claire Wardell, Joseph Horrigan, Ole Graff, Gillian Atkinson, Pinky Dua, Tarek Yousry, David Macmanus, Xavier Montalban
BACKGROUND: Monoclonal antibody therapy against α4β-integrin is efficacious in patients with multiple sclerosis (MS) with some safety concerns. We assessed the safety and efficacy of firategrast, a small oral anti-α4β-integrin molecule, in patients with relapsing remitting MS. METHODS: We did a multicentre, phase 2, randomised, double-blind, placebo-controlled, dose-ranging study in participants with clinically definite relapsing-remitting MS. A 24-week treatment period was followed by 12 weeks of core follow-up and 40 weeks of extended follow-up...
February 2012: Lancet Neurology
Inusha Panigrahi, Pankaj C Vaidya, Deepak Bansal, Ram K Marwaha
Deferasirox (DFX) is a relatively new iron chelator approved by the US Food and Drug Administration for treatment of children >2 years of age. Prospective studies in Asian Indian children are limited. The β-thalassemia patients receiving regular transfusions in the thalassemia ward of an advanced pediatric center were included in this study. Monitoring of side effects was carried out by assessing monthly transaminases and serum creatinine levels. Hemoglobin levels were determined before blood transfusion...
January 2012: Journal of Pediatric Hematology/oncology
Tobias Effertz, Ann-Christin Wilcke
OBJECTIVE: To examine whether the German food industry directs commercials for unhealthy products to children and whether self-administered voluntary restrictions on the promotion of less healthy foods (the EU Pledge) are effective to mitigate this exposure. DESIGN: By analysing German data from television (TV) channels, advertised products were categorized and food products classified as core foods (healthy) and non-core foods (less healthy). Marketing techniques were documented...
August 2012: Public Health Nutrition
Muhammad Younas Khan Barozai, Iftikhar Ahmed Baloch, Muhammad Din
MicroRNAs (miRNAs) are small non-coding RNAs about 20-24 nucleotides long, playing regulatory role. The conserved nature among the various organisms makes them a good source of new miRNAs discovery by comparative genomics approach using bioinformatic tools. A systematic search approach was used for inter-species homologs of miRNA precursors (pre-miRNAs), from known Helianthus expressed sequence tags (ESTs). The study resulted in 61 novel miRNAs belonging to 34 families from Helianthus ESTs. The 28 miRNA families; mir 159,160, 164, 170, 390, 393, 413, 415, 419, 426, 446, 530, 822, 842, 846, 1310, 1888, 2086, 2657, 2667, 2678, 2659, 2911, 2938, 3440, 3521, 3623, and 3630 are reporting for the first time in Helianthus...
March 2012: Molecular Biology Reports
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