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https://www.readbyqxmd.com/read/28231426/engineering-of-anti-cd133-tri-specific-molecule-capable-of-inducing-nk-expansion-and-driving-antibody-dependent-cell-mediated-cytotoxicity-adcc
#1
Jörg U Schmohl, Martin Felices, Felix Oh, Alexander J Lenvik, Aaron M Lebeau, Jayanth Panyam, Jeffrey S Miller, Daniel A Vallera
Purpose: The selective elimination of cancer stem cells (CSCs) in tumor patients is a crucial goal because CSCs cause drug refractory relapse. To improve the current conventional bispecific immune-engager platform, a 16133 BiKE, consisting of scFvs binding FcγRIII (CD16) on NK cells and CD133 on carcinoma cells, was first synthesized and a modified IL-15 crosslinker capable of stimulating NK effector cells was introduced. Materials and Methods: DNA shuffling and ligation techniques were used to assemble and synthesize the 1615133 trispecific NK cell engager (TriKE)...
February 20, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28177737/peak-oxygen-uptake-in-a-sprint-interval-testing-protocol-vs-maximal-oxygen-uptake-in-an-incremental-testing-protocol-and-their-relationship-with-cross-country-mountain-biking-performance
#2
Rafał Hebisz, Paulina Hebisz, Marek Zatoń, Kamil Michalik
The literature finds that the exercise capacity of cyclists is typically assessed using incremental and endurance exercise tests. The aim of the present study was to confirm whether peak oxygen uptake (VO2peak) attained in a sprint interval testing protocol correlated with cycling performance and whether it corresponds to maximal oxygen uptake (VO2max) determined by an incremental testing protocol. A sample of 28 trained mountain bike cyclists executed three performance tests: a) incremental testing protocol (ITP) in which the participant cycled to volitional exhaustion, b) sprint interval testing protocol (SITP) composed of four 30-s maximal intensity cycling bouts interspersed with 90-s recovery periods, c) competition in a simulated MTB race...
December 12, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28103737/a-multidimensional-approach-to-performance-prediction-in-olympic-distance-cross-country-mountain-bikers
#3
Andrew R Novak, Kyle J M Bennett, Job Fransen, Ben J Dascombe
This study adopted a multidimensional approach to performance prediction within Olympic distance cross-country mountain biking (XCO-MTB). Twelve competitive XCO-MTB cyclists (VO2max 60.8 ± 6.7 ml · kg(-1)( )· min(-1)) completed an incremental cycling test, maximal hand grip strength test, cycling power profile (maximal efforts lasting 6-600 s), decision-making test and an individual XCO-MTB time-trial (34.25 km). A hierarchical approach using multiple linear regression analyses was used to develop predictive models of performance across 10 circuit subsections and the total time-trial...
January 20, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28073304/the-impact-of-stress-on-odor-perception
#4
Matthias Hoenen, Oliver T Wolf, Bettina M Pause
The olfactory system and emotional systems are highly intervened and share common neuronal structures. The current study investigates whether emotional (e.g., anger and fear) and physiological (saliva cortisol) stress responses are associated with odor identification ability and hedonic odor judgments (intensity, pleasantness, and unpleasantness). Nineteen men participated in the modified Trier Social Stress Test (TSST) and a control session (cycling on a stationary bike). The physiological arousal was similar in both sessions...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/28034012/physical-fitness-modulates-incidental-but-not-intentional-statistical-learning-of-simultaneous-auditory-sequences-during-concurrent-physical-exercise
#5
Tatsuya Daikoku, Yuji Takahashi, Hiroko Futagami, Nagayoshi Tarumoto, Hideki Yasuda
In real-world auditory environments, humans are exposed to overlapping auditory information such as those made by human voices and musical instruments even during routine physical activities such as walking and cycling. The present study investigated how concurrent physical exercise affects performance of incidental and intentional learning of overlapping auditory streams, and whether physical fitness modulates the performances of learning. Participants were grouped with 11 participants with lower and higher fitness each, based on their Vo2max value...
February 2017: Neurological Research
https://www.readbyqxmd.com/read/28012121/triathlon-training-for-women-breast-cancer-survivors-feasibility-and-initial-efficacy
#6
Alexander V Ng, Alyson N Cybulski, Ashley A Engel, Paula E Papanek, Megan A Sheffer, Leslie J Waltke, Judy A Tjoe
: ᅟ: Exercise can improve quality of life (QOL) in breast cancer survivors. In contrast to many group or home-based exercise programs, little is known about the effectiveness of goal-oriented recreational activities. PURPOSE: The purpose of this study was to evaluate a clinically overseen team triathlon training program on improving physiological and psychosocial health-related measures in female breast cancer survivors. METHODS: Twenty-three participants (age = 48 (8), BMI = 25 (1), mean (SE)) were recruited from a 14-week sprint triathlon (800-m swim, 20-km bike, 5-km run) team training program for women breast cancer survivors (4 (3) years post-surgery, chemo-, or radiation-therapy)...
December 24, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27982249/factors-associated-with-speech-language-disorders-in-motorcycle-accident-victims
#7
Maria Gabriella Pacheco da Silva, Vanessa de Lima Silva, Mirella Rodrigues Bezerra Vilela, Adriana de Oliveira Camargo Gomes, Ilka Veras Falcão, Ana Karina Pessoa da Silva Cabral, Maria Luiza Lopes Timóteo de Lima
Purpose: To investigate factors associated with speech-language disorders in victims of motorcycle accidents. Methods: This is a cross-sectional study. Victims of motorcycle accidents studied were treated at Hospital da Restauração between June and July 2014. The data were collected by consulting the records and direct interviews with these, at admission and after discharge. For analysis were raised single frequencies, average and chi-square test or Fisher's exact test...
November 2016: CoDAS
https://www.readbyqxmd.com/read/27904756/ct-negative-mri-gre-positive-primary-motor-cortex-contusion-causing-isolated-foot-drop
#8
Alexander M Tucker, Tianyi Niu, Daniel T Nagasawa, Richard Everson, Shaina Sedighim, Manuel M Buitrago Blanco
BACKGROUND: Isolated acute foot drop due to traumatic brain injury is exceedingly rare and is often misdiagnosed during initial evaluation. Here, we present the case of a patient who presented with left foot drop after falling off a bicycle. CASE DESCRIPTION: The patient is a 55-year-old male who was mountain biking when he fell, hit his head, and lost consciousness. Neurologic examination of the left leg revealed foot drop, no sensory deficits, and 3+ reflexes at the knee and ankle with clonus...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27890161/primary-or-secondary-tasks-dual-task-interference-between-cyclist-hazard-perception-and-cadence-control-using-cross-modal-sensory-aids-with-rider-assistance-bike-computers
#9
Chao-Yang Yang, Cheng-Tse Wu
This research investigated the risks involved in bicycle riding while using various sensory modalities to deliver training information. To understand the risks associated with using bike computers, this study evaluated hazard perception performance through lab-based simulations of authentic riding conditions. Analysing hazard sensitivity (d') of signal detection theory, the rider's response time, and eye glances provided insights into the risks of using bike computers. In this study, 30 participants were tested with eight hazard perception tasks while they maintained a cadence of 60 ± 5 RPM and used bike computers with different sensory displays, namely visual, auditory, and tactile feedback signals...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27832925/ecological-validity-of-the-german-bruininks-oseretsky-test-of-motor-proficiency-2nd-edition
#10
Sabine Vinçon, Dido Green, Rainer Blank, Ekkehart Jenetzky
The diagnosis of Developmental Coordination Disorder (DCD) is based on poor motor coordination in the absence of other neurological disorders. In order to identify the presence of movement difficulties, a standardised motor assessment is recommended to determine the extent of movement problems which may contribute to deficits in daily task performance. A German version of the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (German BOT-2) was recently published. This study aimed to determine the ecological validity of the German BOT-2 by considering the relationship between assessment of fundamental motor skills with the BOT-2 and performance of everyday motor activities as evaluated by parents...
November 7, 2016: Human Movement Science
https://www.readbyqxmd.com/read/27806079/cycling-on-a-bike-desk-positively-influences-cognitive-performance
#11
Tine Torbeyns, Bas de Geus, Stephen Bailey, Kevin De Pauw, Lieselot Decroix, Jeroen Van Cutsem, Romain Meeusen
PURPOSE: Cycling desks as a means to reduce sedentary time in the office has gained interest as excessive sitting has been associated with several health risks. However, the question rises if people will still be as efficient in performing their desk-based office work when combining this with stationary cycling. Therefore, the effect of cycling at 30% Wmax on typing, cognitive performance and brain activity was investigated. METHODS: After two familiarisation sessions, 23 participants performed a test battery [typing test, Rey auditory verbal learning test (RAVLT), Stroop test and Rosvold continuous performance test (RCPT)] with electroencephalography recording while cycling and sitting on a conventional chair...
2016: PloS One
https://www.readbyqxmd.com/read/27781180/a-pilot-study-examining-the-effects-of-low-volume-high-intensity-interval-training-and-continuous-low-to-moderate-intensity-training-on-quality-of-life-functional-capacity-and-cardiovascular-risk-factors-in-cancer-survivors
#12
Kellie Toohey, Kate L Pumpa, Leonard Arnolda, Julie Cooke, Desmond Yip, Paul S Craft, Stuart Semple
PURPOSE: The aim of this study was to evaluate the effects of low-volume high-intensity interval training and continuous low to moderate intensity training on quality of life, functional capacity and cardiovascular disease risk factors in cancer survivors. METHODS: Cancer survivors within 24 months post-diagnosis were randomly assigned into the low-volume high-intensity interval training group (n = 8) or the continuous low to moderate intensity training group (n = 8) group for 36 sessions (12 weeks) of supervised exercise...
2016: PeerJ
https://www.readbyqxmd.com/read/27763583/altered-gas-exchange-at-peak-exercise-in-obese-adolescents-implications-for-verification-of-effort-during-cardiopulmonary-exercise-testing
#13
Nastasia Marinus, Liene Bervoets, Guy Massa, Kenneth Verboven, An Stevens, Tim Takken, Dominique Hansen
BACKGROUND: Cardiopulmonary exercise testing is advised ahead of exercise intervention in obese adolescents to assess medical safety of exercise and physical fitness. Optimal validity and reliability of test results are required to identify maximal exercise effort. As fat oxidation during exercise is disturbed in obese individuals, it remains an unresolved methodological issue whether the respiratory gas exchange ratio (RER) is a valid marker for maximal effort during exercise testing in this population...
October 20, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27747366/pilot-testing-of-a-sampling-methodology-for-assessing-seed-attachment-propensity-and-transport-rate-in-a-soil-matrix-carried-on-boot-soles-and-bike-tires
#14
Nigel Hardiman, Kristina Charlotte Dietz, Ian Bride, Louis Passfield
Land managers of natural areas are under pressure to balance demands for increased recreation access with protection of the natural resource. Unintended dispersal of seeds by visitors to natural areas has high potential for weedy plant invasions, with initial seed attachment an important step in the dispersal process. Although walking and mountain biking are popular nature-based recreation activities, there are few studies quantifying propensity for seed attachment and transport rate on boot soles and none for bike tires...
January 2017: Environmental Management
https://www.readbyqxmd.com/read/27742438/variability-of-airborne-particle-metrics-in-an-urban-area
#15
V Rizza, L Stabile, G Buonanno, L Morawska
In the present study a mobile monitoring approach (i.e. bike with onboard instruments) was proposed and applied to investigate the spatial variability of all the key airborne particle metrics in an Italian urban area from a statistical point of view. Particle number, alveolar-deposited surface area, and PM10 concentrations were measured through hand-held monitors and compared to simultaneous background concentrations by means of non-parametric tests and further post-hoc tests (Kruskal-Wallis test). Streets characterized by exposure levels statistically higher than the background levels for all the particle metrics were identified for different seasons in a pilot urban area (Cassino, Italy)...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27697429/longer-versus-shorter-duration-of-supervised-rehabilitation-after-lung-transplantation-a%C3%A2-randomized-trial
#16
Louise M Fuller, Brenda Button, Ben Tarrant, Ranjana Steward, Lisa Bennett, Greg Snell, Anne E Holland
OBJECTIVE: To investigate the effects of a supervised longer- (14wk) versus shorter-duration (7wk) rehabilitation program after lung transplantation (LTX). DESIGN: Randomized controlled trial. SETTING: Outpatient rehabilitation gym setting. PARTICIPANTS: Post-LTX patients aged ≥18 years (N=66; 33 women; mean age, 51±13y) who had undergone either single LTX or bilateral LTX. INTERVENTION: Outpatient rehabilitation program consisting of thrice-weekly sessions with cardiovascular training on bike ergometer and treadmill plus upper and lower limb strength training...
February 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27679447/modeling-and-optimization-of-airbag-helmets-for-preventing-head-injuries-in-bicycling
#17
Mehmet Kurt, Kaveh Laksari, Calvin Kuo, Gerald A Grant, David B Camarillo
Bicycling is the leading cause of sports-related traumatic brain injury. Most of the current bike helmets are made of expanded polystyrene (EPS) foam and ultimately designed to prevent blunt trauma, e.g., skull fracture. However, these helmets have limited effectiveness in preventing brain injuries. With the availability of high-rate micro-electrical-mechanical systems sensors and high energy density batteries, a new class of helmets, i.e., expandable helmets, can sense an impending collision and expand to protect the head...
September 27, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27613434/the-cost-effectiveness-of-bike-lanes-in-new-york-city
#18
Jing Gu, Babak Mohit, Peter Alexander Muennig
BACKGROUND: Our objective is to evaluate the cost-effectiveness of investments in bike lanes using New York City's (NYC) fiscal year 2015 investment as a case study. We also provide a generalizable model, so that localities can estimate their return on bike lane investments. METHODS AND FINDINGS: We evaluate the cost-effectiveness of bike lane construction using a two-stage model. Our regression analysis, to estimate the marginal addition of lane miles on the expansion in bike ridership, reveals that the 45...
September 9, 2016: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/27552233/the-validity-and-reliability-of-a-sample-of-10-wattbike-cycle-ergometers
#19
Barney Wainwright, Carlton Brian Cooke, John Paul O'Hara
The purpose of the study was to assess the validity and inter-bike reliability of 10 Wattbike cycle ergometers, and to assess the test-retest reliability of one Wattbike. Power outputs from 100 to 1000 W were applied using a motorised calibration rig (LODE) at cadences of 70, 90, 110 and 130 rev · min(-1), which created nineteen different intensities for comparison. Significant relationships (P < 0.01, r(2) = 0.99) were found between each of the Wattbikes and the LODE. Each Wattbike was found to be valid and reliable and had good inter-bike agreement...
August 23, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27548562/perception-of-safety-and-liking-associated-to-the-colour-intervention-of-bike-lanes-contribution-from-the-behavioural-sciences-to-urban-design-and-wellbeing
#20
Pablo Vera-Villarroel, Daniela Contreras, Sebastián Lillo, Christian Beyle, Ariel Segovia, Natalia Rojo, Sandra Moreno, Francisco Oyarzo
The perception of colour and its subjective effects are key issues to designing safe and enjoyable bike lanes. This paper addresses the relationship between the colours of bike lane interventions-in particular pavement painting and intersection design-and the subjective evaluation of liking, visual saliency, and perceived safety related to such an intervention. Utilising images of three real bike lane intersections modified by software to change their colour (five in total), this study recruited 538 participants to assess their perception of all fifteen colour-design combinations...
2016: PloS One
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