Tianyang Mao, Jooyoung Kim, Mario A Peña-Hernández, Gabrielee Valle, Miyu Moriyama, Sophia Luyten, Isabel M Ott, Maria Luisa Gomez-Calvo, Jeff R Gehlhausen, Emily Baker, Benjamin Israelow, Martin Slade, Lokesh Sharma, Wei Liu, Changwan Ryu, Asawari Korde, Chris J Lee, Valter Silva Monteiro, Carolina Lucas, Huiping Dong, Yi Yang, Smita Gopinath, Craig B Wilen, Noah Palm, Charles S Dela Cruz, Akiko Iwasaki
Respiratory virus infections in humans cause a broad-spectrum of diseases that result in substantial morbidity and mortality annually worldwide. To reduce the global burden of respiratory viral diseases, preventative and therapeutic interventions that are accessible and effective are urgently needed, especially in countries that are disproportionately affected. Repurposing generic medicine has the potential to bring new treatments for infectious diseases to patients efficiently and equitably. In this study, we found that intranasal delivery of neomycin, a generic aminoglycoside antibiotic, induces the expression of interferon-stimulated genes (ISGs) in the nasal mucosa that is independent of the commensal microbiota...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America