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meningitis lancet

Yi-Yi Wang, Bing-di Xie
Central nervous system (CNS) disease caused by Mycobacterium tuberculosis (MTB) is highly devastating. Tuberculous meningitis (TBM) is the most common form of CNS tuberculosis (TB). Rapid, sensitive, and affordable diagnostic tests are not available. Ziehl-Neelsen (ZN) stain has a very low sensitivity in cases of TBM, the sensitivity rates is of about 10-20%.The detection rate can be improved by taking large volume CSF samples (>6 ml) and prolonged slide examination (30 min). Culture of MTB from the CSF is slow and insufficiently sensitive...
2018: Methods in Molecular Biology
Yueli Zou, Junying He, Li Guo, Hui Bu, Yajuan Liu
BACKGROUND: Tuberculous meningitis is the most lethal form of tuberculosis, but current diagnostic methods are inadequate. The measurement of cerebrospinal fluid parameters can provide early information for diagnosis. The present study focus on the validity of the cut-off value of cerebrospinal fluid parameters according to the Lancet consensus of scoring system for diagnosis of tuberculous meningitis. METHOD: A total of 100 confirmed patients were enrolled in this study...
September 2015: Diagnostic Cytopathology
Hakan Erdem, Seniha Senbayrak, Serap Gencer, Rodrigo Hasbun, Mustafa Kasim Karahocagil, Gonul Sengoz, Hasan Karsen, Selçuk Kaya, Rok Civljak, Ayşe Seza Inal, Abdullah Umut Pekok, Mustafa Kemal Celen, Secil Deniz, Mehmet Ulug, Tuna Demirdal, Mustafa Namiduru, Recep Tekin, Tumer Guven, Emine Parlak, Sibel Bolukcu, Meltem Avci, Oğuz Reşat Sipahi, Saygin Nayman-Alpat, Kadriye Yaşar, Filiz Pehlivanoğlu, Emel Yilmaz, Selma Ates-Guler, Esmeray Mutlu-Yilmaz, Selma Tosun, Fatma Sirmatel, Elif Şahin-Horasan, Ayhan Akbulut, Işik Somuncu Johansen, Soline Simeon, Ayşe Batirel, Nefise Öztoprak, Yasemin Cag, Melanie Catroux, Yves Hansmann, Ayten Kadanali, Huseyin Turgut, Ali Irfan Baran, Hanefi Cem Gul, Gokhan Karaahmetoglu, Mahmut Sunnetcioglu, Asli Haykir-Solay, Affan Denk, Celal Ayaz, Sukran Kose, Levent Gorenek
BACKGROUND: The Thwaites and Lancet scoring systems have been used in the rapid diagnosis of tuberculous meningitis (TBM). However, brucellar meningoencephalitis (BME) has similar characteristics with TBM. The ultimate aim of this study is to infer data to see if BME should be included in the differential diagnosis of TBM when these two systems suggest the presence of TBM. METHOD: BME and TBM patients from 35 tertiary hospitals were included in this study. Overall 294 adult patients with BME and 190 patients with TBM were enrolled...
March 2015: Travel Medicine and Infectious Disease
The Lancet Infectious Diseases
No abstract text is available yet for this article.
May 2014: Lancet Infectious Diseases
Marilyn E Levi
West Nile virus infection has become the predominant cause of flavivirus-associated encephalitis in the US. While 80 % of infected individuals are asymptomatic, 20 % develop symptoms including fever, headache, transient rash and gastrointestinal symptoms. Among the immunocompetent population, 1 in 150 develop neuroinvasive disease characterized by acute flaccid paralysis, Parkinsonian cogwheel rigidity, meningitis, encephalitis, meningoencephalitis and asymmetric muscle weakness (Mostashari et al. in Lancet 358:261-264, 2001)...
November 15, 2013: Current Infectious Disease Reports
Roshan Kurien, Thambu David Sudarsanam, Kurien Thomas
OBJECTIVES: Tuberculous meningitis (TBM) is a major clinical and public health problem, both for diagnosis and management. We compare two established scoring systems, Thwaites and the Lancet consensus scoring system for the diagnosis of TB and compare the clinical outcome in a tertiary care setting. METHODS: We analyzed 306 patients with central nervous system (CNS) infection over a 5-year period and classified them based on the unit's diagnosis, the Thwaites classification as well as the newer Lancet consensus scoring system...
May 2013: Oman Medical Journal
Muhamed-Kheir Taha, Ala-Eddine Deghmane
Evaluation of: Pelkonen T, Roine I, Cruzeiro ML, Pitkaranta A, Kataja M, Peltola H. Slow initial β-lactam infusion and oral paracetamol to treat childhood bacterial meningitis: a randomised, controlled trial. Lancet Infect. Dis. 11(8), 613-621 (2011). Acute bacterial meningitis is a medical emergency that requires prompt management. Despite effective antibiotic and adjunctive therapies, mortality is still unacceptably high in acute bacterial meningitis in children as this mortality did not substantially improve since the first use of antimicrobial therapies in the mid-20th century...
October 2011: Future Microbiology
Or Cohen-Inbar, Jean F Soustiel, Menashe Zaaroor
OBJECTIVE: The purpose of the study was to define and identify prognostic indicators within an elderly population of patients suffering from intracranial meningiomas. The clinical presentation of the patient with meningioma is diverse, manifesting as a different clinical entity in the elderly patient compared to a similar type of tumor in a young patient. METHODS: Two hundred fifty patients aged over 65 years admitted to RAMBAM Medical Center with meningiomas from 1995-2005 were characterized...
January 2010: Acta Neurochirurgica
Che-Hung Lee, Wen-Chun Kuo, Suresh Beri, Subash Kapre, Jayant S Joshi, Nancy Bouveret, F Marc LaForce, Carl E Frasch
Periodic epidemics of group A meningococcal (Mn A) meningitis continue to occur in sub-Saharan Africa. For its prevention, a Mn A polysaccharide (PS)-tetanus toxoid (TT) conjugate vaccine was developed using reductive amination of polysaccharide aldehydes and toxoid hydrazides. In mouse immunization studies, a schedule of three bi-weekly s.c. immunizations of 0.1 or 1mug of the conjugate (PS content) without an adjuvant induced serum antibody levels of >10,000units/mL measured by enzyme-linked immunosorbent assay (ELISA) as compared to approximately 100units/mL in PS control mice...
January 29, 2009: Vaccine
Sung-Han Kim, Kon Chu, Su-Jin Choi, Kyoung-Ho Song, Hong-Bin Kim, Nam-Joong Kim, Seong-Ho Park, Byung-Woo Yoon, Myoung-don Oh, Kang-Won Choe
In active tuberculosis (TB), Mycobacterium tuberculosis-specific T cells are compartmentalized more to the site of infection than to the circulating blood. Therefore, an M. tuberculosis-specific enzyme-linked immunospot (ELISPOT) assay with samples from the site of infection may permit a more sensitive or specific diagnosis of active central nervous system (CNS) TB than that achieved by the assay with blood alone. Therefore, we prospectively evaluated the usefulness of circulating and compartmentalized mononuclear cell (MC; i...
September 2008: Clinical and Vaccine Immunology: CVI
M M M Salimans, W A Bax, F Stegeman, M van Deuren, A K M Bartelink, H van Dijk
In a recent report, our group presented clinical research data supporting the role of mannose-binding lectin (MBL) deficiency in susceptibility to meningococcal disease (W. A. Bax, O. J. J. Cluysenaer, A. K. M. Bartelink, P. C. Aerts, R. A. B. Ezekowitz, and H. van Dijk, Lancet 354:1094-1095, 1999). This association was reported earlier by Hibberd et al. (M. L. Hibberd, M. Sumiya, J. A. Summerfield, R. Booy, M. Levin, and the Meningococcal Research Group, Lancet 353:1049-1053, 1999) but was not based on family data...
July 2004: Clinical and Diagnostic Laboratory Immunology
J Nedelec, J Boucraut, J M Garnier, D Bernard, G Rougon
Human brain tissue shares alpha 2-8 linked polymers of neuraminic acid with the carbohydrates expressed on the capsule of group B Neisseria meningitidis bacteria (Finne et al. (1983) Lancet ii, 355-357; Finne (1985) Trends Biochem. Sci. 10, 129-132; Rougon et al. (1986) J. Cell. Biol. 103, 2429-2437). We report that sera from patients suffering from group B meningitis exhibited IgM antibodies directed against the embryonic, but not the adult, form of neural cell adhesion molecules (N-CAM). These sera also stained live ATt20 cells as well as neuron membranes in mouse embryonic brain cultures...
September 1990: Journal of Neuroimmunology
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