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https://www.readbyqxmd.com/read/29473323/adult-spinal-opioid-receptor-%C3%A2%C2%B51-expression-after-incision-is-altered-by-early-life-repetitive-tactile-and-noxious-procedures-in-rats
#1
Nynke J van den Hoogen, Roel Ri van Reij, Jacob Patijn, Dick Tibboel, Elbert Aj Joosten
Clinical and experimental data suggests that noxious stimulation at critical stages of development results in long-term changes on nociceptive processing in later life. Here, we use an established, well-documented rat model of repetitive noxious procedures closely mimicking the clinical situation in the NICU. In order to understand molecular changes underlying the long-term consequences of repetitive stimulation of the developing nociceptive system the present study aims to analyse the presence of the µ-opioid-receptor-1 (OPRM1)...
February 22, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29471833/plasmodium-falciparum-diagnostic-tools-in-hiv-positive-under-5-year-olds-in-two-art-clinics-in-ghana-are-there-missed-infections
#2
Ewurama D A Owusu, Samson K Djonor, Charles A Brown, Martin P Grobusch, Petra F Mens
BACKGROUND: Plasmodium falciparum, the most dominant species in sub-Saharan Africa, causes the most severe clinical malaria manifestations. In resource-limited Ghana, where malaria and HIV geographically overlap, histidine-rich protein 2 (HRP2)-based rapid diagnostic test (RDT) is a faster, easier and cheaper alternative to clinical gold standard light microscopy. However, mutations in parasite hrp2 gene may result in missed infections, which have severe implications for malaria control...
February 23, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29461689/clinical-associations-between-allergies-and-rapid-eye-movement-sleep-disturbances
#3
Shelley R Berson, Jaclyn Klimczak, Elizabeth A Prezio, Shirley Hu, Manoj Abraham
BACKGROUND: Allergic rhinitis, an immunoglobulin E inflammatory condition including nasal congestion, obstruction, sneezing, pruritus, and fatigue symptoms, has significant impact on quality of life and impairs sleep. Sleep-disordered breathing (SDB) patients often have normal all-night apnea-hypopnea (AHI) or respiratory-disturbance (RDI) indices on polysomnography (PSG). We hypothesized that the rapid eye motion-respiratory disturbance index (REM-RDI) may be a novel predictor of allergic status...
February 20, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29460908/-association-of-sleep-disorders-with-headache
#4
A V Golenkov, F V Orlov, S P Sapozhnikov, V A Kozlov
AIM: The aim of the present study was to investigate the connection of sleep disorders (SD) with a headache (HA) among the representative sample of population. MATERIAL AND METHODS: 1115 inhabitants of Chuvashia (491 men and 624 women) aged from 18 to 70 years old have been interviewed (middle age 38.7±13.9 years old); respondents under 18 and over 70 years old were not included into the research. There were 690 city residents, and 425 residents of the rural areas...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29455358/the-use-of-biomarkers-to-predict-aero-allergen-and-food-immunotherapy-responses
#5
REVIEW
Sayantani B Sindher, Andrew Long, Swati Acharya, Vanitha Sampath, Kari C Nadeau
The incidence of allergic conditions has continued to rise over the past several decades, with a growing body of research dedicated toward the treatment of such conditions. By driving a complex range of changes in the underlying immune response, immunotherapy is the only therapy that modulates the immune system with long-term effects and is presently utilized for the treatment of several atopic conditions. Recent efforts have focused on identifying biomarkers associated with these changes that may be of use in predicting patients with the highest likelihood of positive clinical outcomes during allergen immunotherapy (AIT), providing guidance regarding AIT discontinuation, and predicting symptomatic relapse and the need for booster AIT after therapy...
February 17, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29440935/disruption-in-the-diabetic-device-care-market
#6
REVIEW
Utkarsh Ojha, Raihan Mohammed
As diabetes mellitus (DM) has approached pandemic proportions, the pressure for effective glycemic management is mounting. The starting point for managing and living well with DM involves early diagnosis and monitoring blood glucose levels. Therefore, self-monitoring of blood glucose (SMBG) can help patients maintain their blood glucose levels within the appropriate range. The general principle behind the current SMBG method involves a finger prick test to obtain a blood drop, which is applied onto a reagent strip and read by an automated device...
2018: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29423377/accuracy-of-serum-specific-ige-test-with-microfluidic-array-enzyme-linked-immunosorbent-assay-for-diagnosing-inhalant-allergen-sensitization-in-asthma-and-or-rhinitis-allergy-patients-in-jakarta-indonesia
#7
Julfreser Sinurat, Iris Rengganis, Cleopas Martin Rumende, Kuntjoro Harimurti
Background: Asthma and allergic rhinitis are a global health burden. Inhalant allergens worsen the symptoms and clinical manifestations of asthma and allergic rhinitis. Skin prick test is the gold standard for diagnosing allergen sensitization but is associated with some limitations. In contrast, in vitro serum-specific immunoglobulin E (SSIgE) test is convenient and is not associated with an anaphylactic risk. Objective: The present study compared the accuracy of the SSIgE test by using microfluidic array enzyme-linked immunosorbent assay (ELISA) with that of the skin prick test for diagnosing inhalant allergen sensitization in patients with asthma and/or allergic rhinitis...
January 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29422859/successful-subcutaneous-allergen-specific-immunotherapy-in-refractory-atopic-keratoconjunctivitis-a-case-report
#8
Passara Jongkhajornpong, Wannada Laisuan
Purpose: We report a case of refractory atopic keratoconjunctivitis (AKC) which was successfully treated with subcutaneous immunotherapy (SCIT). Case Report: A 22-year-old woman presented with severe allergic conjunctivitis for one and a half year. She failed to respond to conventional topical anti-allergic medications, topical corticosteroid, as well as topical cyclosporine A. Therefore, oral corticosteroids had to be prescribed to control the exacerbation for 1 year...
September 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29422048/tools-for-surveillance-of-anti-malarial-drug-resistance-an-assessment-of-the-current-landscape
#9
REVIEW
Christian Nsanzabana, Djibrine Djalle, Philippe J Guérin, Didier Ménard, Iveth J González
To limit the spread and impact of anti-malarial drug resistance and react accordingly, surveillance systems able to detect and track in real-time its emergence and spread need to be strengthened or in some places established. Currently, surveillance of anti-malarial drug resistance is done by any of three approaches: (1) in vivo studies to assess the efficacy of drugs in patients; (2) in vitro/ex vivo studies to evaluate parasite susceptibility to the drugs; and/or (3) molecular assays to detect validated gene mutations and/or gene copy number changes that are associated with drug resistance...
February 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29421065/capsaicin-sensitive-cutaneous-primary-afferents-convey-electrically-induced-itch-in-humans
#10
Hjalte H Andersen, Antoinette I M van Laarhoven, Frederik D Justesen, Jacob B Pedersen, Laurits L Sørensen, Line P Jensen, Lars Arendt-Nielsen
Specially designed transcutaneous electrical stimulation paradigms can be used to provoke experimental itch. However, it is unclear which primary afferent fibers are activated and whether they represent pathophysiologically relevant, C-fiber mediated itch. Since low-threshold mechano-receptors have recently been implicated in pruriception we aimed to characterize the peripheral primary afferent subpopulation conveying electrically evoked itch in humans (50Hz stimulation, 100μs square pulses, stimulus-response function to graded stimulus intensity)...
February 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29413342/component-resolved-diagnosis-in-selecting-patients-for-yellowjacket-venom-immunotherapy
#11
Anna Kaarina Kukkonen, Anna Susanna Pelkonen, Sanna Marika Edelman, Paula Maria Kauppi, Mika Juhani Mäkelä
BACKGROUND: Venom immunotherapy is effective in preventing systemic allergic reactions (SARs), but the diagnosis of venom allergy is problematic. OBJECTIVE: To compare the performance of component-resolved diagnosis and conventional tests in patients referred for venom immunotherapy. METHODS: We measured serum-specific immunoglobulin E to yellowjacket and honeybee venoms (Ves v 1 and Ves v 5 and Api m 1), cross-reactive carbohydrate determinants, serum basal tryptase (ImmunoCAP, ThermoFisher Scientific, Uppsala, Sweden), and skin prick test reactions in 84 patients referred to receive venom immunotherapy...
February 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29411556/dog-and-cat-allergies-and-allergen-avoidance-measures-in-korean-adult-pet-owners-who-participated-in-a-pet-exhibition
#12
Min Suk Yang, Sang Pyo Lee, Young Jae Kwon, Sang Min Lee
PURPOSE: This study evaluated dog and cat allergies and their association with allergen avoidance measures in Korean adults. METHODS: The study population consisted of 537 adults who currently kept dogs or cats and participated in a pet exhibition in Korea. The subjects were asked to complete questionnaires regarding pet ownership, allergen avoidance, and allergy symptoms, and underwent skin prick tests. They were considered to have a dog or cat allergy if they suffered from one or more of allergy symptoms during contact with their pets...
March 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29408573/malaria-sickle-cell-disease-hiv-and-co-trimoxazole-prophylaxis-an-observational-study
#13
Ewurama D A Owusu, Nana S A Cofie, Edna A Nai, Kerstin Klipstein-Grobusch, Charles A Brown, Petra F Mens, Martin P Grobusch
OBJECTIVES: This observational study recorded the malaria and sickle cell disease (SCD) profile of people living with HIV/AIDS (PLHA) and determined whether prophylactic co-trimoxazole (CTX) and haemoglobin S (Hb S) allele influenced malaria episodes. METHODS: Sickling status, malaria episodes and HIV type, among others, were retrospectively extracted from the clinical records of 1,001 patients of the ART clinic in Ridge Regional Hospital (Accra, Ghana) between 2010 and 2015...
February 2, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29402723/reduction-of-respiratory-infections-in-asthma-patients-supplemented-with-vitamin-d-is-related-to-increased-serum-il-10-and-ifn%C3%AE-levels-and-cathelicidin-expression
#14
E Ramos-Martínez, M R López-Vancell, J C Fernández de Córdova-Aguirre, J Rojas-Serrano, A Chavarría, A Velasco-Medina, G Velázquez-Sámano
BACKGROUND: Vitamin D is a molecule that modulates the immune response and shows anti-inflammatory effects that are beneficial for the control of chronic diseases such as asthma. The trial aim was to explore the effect of vitamin D supplementation on the colonization of pathogenic bacteria in the upper respiratory tract of allergic asthmatic patients. METHODS: This study was conducted in 86 patients between 18 and 50 years of age who were randomly divided into two groups...
February 2, 2018: Cytokine
https://www.readbyqxmd.com/read/29391127/knowledge-attitudes-and-practices-regarding-malaria-in-people-living-with-hiv-in-rural-and-urban-ghana
#15
Ewurama D A Owusu, Anne Lia Cremers, Charles A Brown, Petra F Mens, Martin P Grobusch
BACKGROUND: One of the malaria vulnerable groups is people living with HIV. This study investigated knowledge, attitude and practices (KAP) towards malaria in people living with HIV attending anti-retroviral therapy (ART) clinics in rural and urban Ghana. METHODS: In this descriptive cross-sectional study patients attending the ART clinics in Atibie (rural area) and Accra (urban area) were interviewed on their knowledge, attitude and practices regarding malaria...
January 30, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29385067/sensing-technologies-for-detection-of-acetone-in-human-breath-for-diabetes-diagnosis-and-monitoring
#16
REVIEW
Valentine Saasa, Thomas Malwela, Mervyn Beukes, Matlou Mokgotho, Chaun-Pu Liu, Bonex Mwakikunga
The review describes the technologies used in the field of breath analysis to diagnose and monitor diabetes mellitus. Currently the diagnosis and monitoring of blood glucose and ketone bodies that are used in clinical studies involve the use of blood tests. This method entails pricking fingers for a drop of blood and placing a drop on a sensitive area of a strip which is pre-inserted into an electronic reading instrument. Furthermore, it is painful, invasive and expensive, and can be unsafe if proper handling is not undertaken...
January 31, 2018: Diagnostics
https://www.readbyqxmd.com/read/29384114/freshly-squeezed-anaphylaxis-caused-by-drone-larvae-juice
#17
J Stoevesandt, A Trautmann
Drone larvae are mostly considered a by-product of beekeeping, but have recently been advo-cated as a high-protein source of food. There are as yet no data concerning their allergenic po-tential. We report on a 29-year old bee keeper who experienced an anaphylactic reaction following the consumption of a freshly prepared beverage from raw drone larvae. Larvae-specific sensitization was confirmed by prick-to-prick and basophil activation testing. Bee stings and classical bee products including honey and royal jelly were tolerated...
November 30, 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29384109/local-anesthetics-allergy-who-should-be-tested
#18
I YIlmaz, S K Özdemir, Ö Aydin, G E Çelik
Objective. To document the test results of patients referred to our clinic for testing with local anesthetics (LAs) in real life conditions and provide data related to the necessity of these tests. Methods. All consecutive subjects who were referred to be evaluated for LA allergy during a two-year follow up were included in the analysis. All subjects underwent skin prick / intradermal tests followed by a subcutaneous provocation test with the LAs tested. Results. A total of 228 subjects were included. The main referral reason was the presence of a history of drug hypersensitivity reaction (DHR) to drugs other than LAs (n = 128; 56%), whereas a history of LA allergy constituted the second most common referral reason (n = 64, 28...
November 22, 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29383926/piperacillin-tazobactam-anaphylaxis-a-rare-cause-of-occupational-disease
#19
J Gaspar-Marques, E Finelli, P C Martins, S Prates, P Leiria-Pinto
Piperacillin is a beta-lactam antibiotic of penicillin family. Some penicillins were report-ed as occupational diseases cause, but piperacillin anaphylaxis with occupational sensi-tization is rare. We describe the case of a female nurse with recurrent anaphylaxis in last few months without apparent cause, only in work environment. Latex allergy was excluded after negative latex glove provocation. Later during diagnostic workup, the patient reported a similar reaction minutes after piperacillin preparation. She denied any previous antibiotic therapeutic exposure...
November 20, 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29381818/role-of-omalizumab-in-insulin-hypersensitivity-a-case-report-and-review-of-the-literature
#20
S Mishra, L Connors, B Tugwell
BACKGROUND: Insulin allergy is a rare yet severe side effect of exogenous insulin use. Management typically involves use of alternative antihyperglycaemic agents, symptom control with antihistamines, use of different insulin formulations, and induction of tolerance with incremental doses of insulin. This treatment regimen is not always successful, and the use of omalizumab, an anti-IgE monoclonal antibody, has been used to induce tolerance to insulin. CASE REPORT: G...
January 30, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
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