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https://www.readbyqxmd.com/read/29229196/impact-of-allergy-on-phenotypic-and-endotypic-profiles-of-nasal-polyposis
#1
G Mortuaire, I Gengler, M Balden, M Capron, G Lefèvre
OBJECTIVES: To assess the impact of allergy on clinical presentations (phenotypes) and inflammatory patterns (endotypes) of chronic rhinosinusitis with nasal polyps (CRSwNP). METHODS: A single-center prospective study was conducted over an 18-month period. Fifty-seven patients with refractory CRSwNP were included. The diagnosis of allergy was based on concordant skin prick tests and symptoms. Phenotypes were determined on symptom severity score, polyp size classification and Lund-Mackay CT staging...
December 8, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29227043/the-association-of-air-pollutants-and-allergic-and-nonallergic-rhinitis-in-chronic-rhinosinusitis
#2
Leila J Mady, Hannah L Schwarzbach, John A Moore, Robert M Boudreau, Thomas M Kaffenberger, Thomas J Willson, Stella E Lee
BACKGROUND: There has been little investigation regarding air quality and rhinitis in the pathophysiology of upper airway disease. In this study, we assessed the impact of inhalant pollutants (particulate matter 2.5 [PM2.5 ] and black carbon [BC]) on allergic rhinitis and chronic rhinosinusitis (CRS) disease severity. METHODS: CRS patients with nasal polyps (CRSwNP) and without polyps (CRSsNP) were identified. Spatial modeling from pollutant monitoring sites was used to estimate exposures for patients meeting the inclusion criteria (total, n = 125; CRSsNP, n = 67; CRSsNP, n = 58)...
December 11, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29226807/asthma-family-history-of-drug-allergy-and-age-predict-amoxicillin-allergy-in-children
#3
Yoram Faitelson, Mona Boaz, Ilan Dalal
BACKGROUND: Suspected adverse reactions to amoxicillin are common, but there are no known factors that can predict amoxicillin allergy in children. In addition, methods used for the diagnosis of amoxicillin allergy are not standardized and their role in diagnosis is not clear. OBJECTIVE: To identify predictive factors and to assess the role of skin test in the diagnosis of amoxicillin allergy in children. METHODS: Children with a history of immediate (excluding anaphylaxis) or nonimmediate reactions to amoxicillin were tested by skin prick test, followed by oral graded challenge with amoxicillin...
December 6, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29211564/is-the-farm-effect-hypothesis-still-current-atopy-and-allergic-diseases-in-rural-and-urban-children-in-poland
#4
Agnieszka Mazur, Anna Szylling, Teresa Bielecka, Agnieszka Strzelak, Marek Kulus
OBJECTIVE: The prevalence of allergic diseases has reached epidemic proportions in the Western world. Although farm-living has been associated with a lower prevalence of asthma and atopy, a marked increase in atopy among rural populations after accession to the European Union has been recently reported in Poland. Here, we aimed to investigate the effect of living environment on the prevalence of atopy and allergic diseases in Polish children. METHODS: 400 schoolchildren aged 10-14 years from the capital city (223) and from traditional rural part of the country (177) were recruited from June to November 2011...
December 6, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29209493/comparison-of-atopy-patch-testing-to-skin-prick-testing-for-diagnosing-mite-induced-atopic-dermatitis-a-systematic-review-and-meta-analysis
#5
REVIEW
Yumei Liu, Jianglong Peng, Ying Zhou, Yubao Cui
Background: Atopic dermatitis (AD) can occur after contact with aeroallergens like house dust mites, pollen, and animal dander. Despite its controversial diagnostic value, the atopy patch test (APT) has been used as an important tool in the diagnosis of AD caused by house dust mites. Here, we present a meta-analysis comparing APT to the common skin prick test (SPT) in the diagnosis of mite-induced AD. Methods: A structured search was performed using online databases and bibliographies published as of April 30, 2017...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29202821/effects-of-treatment-changes-on-asthma-phenotype-prevalence-and-airway-neutrophil-function
#6
Collin R Brooks, Christine J Van Dalen, Elizabeth Harding, Ian F Hermans, Jeroen Douwes
BACKGROUND: Asthma inflammatory phenotypes are often defined by relative cell counts of airway eosinophils/neutrophils. However, the importance of neutrophilia remains unclear, as does the effect of ICS treatment on asthma phenotypes and airway neutrophil function. The purpose of this study was to assess asthma phenotype prevalence/characteristics in a community setting, and, in a nested preliminary study, determine how treatment changes affect phenotype stability and inflammation, with particular focus on airway neutrophils...
December 4, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29201066/anaphylactic-shock-following-castor-bean-contact-a-case-report
#7
Y Coattrenec, D Jaques, P Jandus, T Harr, D Spoerl
Background: The castor bean plant, Ricinus communis, is known to have allergenic and toxic properties. Castor bean allergy has been described mainly as an occupational inhalation allergy in laboratory workers, in persons working in oil processing mills or in agricultural industry. So far, only one case of anaphylactic reaction due to castor bean sensitization confirmed by specific IgE has been described in literature. Case presentation: A 30-year-old woman presented to the emergency room with severe angioedema followed by urticaria, hypotension and tachycardia...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29199967/different-skin-prick-test-sensitization-patterns-do-not-influence-the-response-to-omalizumab-in-severe-asthma
#8
B Sposato, M Scalese, M Milanese, S Masieri, C Cavaliere, M Latorre, N Scichilone, A Matucci, A Vultaggio, A Ricci, A Cresti, P L Paggiaro
No abstract text is available yet for this article.
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29190791/can-self-testing-increase-hiv-testing-among-men-who-have-sex-with-men-a-systematic-review-and-meta-analysis
#9
Ci Zhang, Xianhong Li, Mary-Lynn Brecht, Deborah Koniak-Griffin
BACKGROUND: Globally, four out of ten individuals living with HIV have not been tested for HIV. Testing is especially important for men who have sex with men (MSM), among whom an increasing HIV epidemic has been identified in many regions of the world. As a supplement to site-based HIV testing services, HIV self-testing (HIVST) provides a promising approach to promote HIV testing. However, evidence is scattered and not well-summarized on the effect of HIVST to improve HIV testing behaviors, especially for MSM...
2017: PloS One
https://www.readbyqxmd.com/read/29189183/ige-sensitization-to-anisakis-simplex-and-diet-recommendation-in-a-polycentric-study
#10
Rosalba Buquicchio, Maria Teresa Ventura, Pier Luigi Traetta, Saverio Nenna, Giuseppe Iadarola, Thea Magrone
BACKGROUND: Allergy to Anisakis simplex (s.) is spreading due to the increased consumption of raw, smoked or marinated fish. In humans, Anisakis s. can directly attack the gastrointestinal mucosa, provoking a parasitosis known as anisakiasis, or giving rise to the formation of IgE and, finally, inducing IgE-mediated reactions like urticaria, angioedema and anaphylactic shock. During recent years, a dietary approach to Anisakis s. infestation has also been addressed. METHODS: A total of 620 patients with urticaria, angioedema, or both and a history of anaphylaxis following consumption of raw, smoked or marinated fish were recruited, evaluated for specific IgE levels to Anisakis s...
November 29, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29185250/management-of-hepatitis-c-in-decentralised-versus-centralised-drug-substitution-programmes-and-minimally-invasive-point-of-care-tests-to-close-gaps-in-the-hcv-cascade
#11
Andrea Bregenzer, Anna Conen, Jürg Knuchel, Andrée Friedl, Franz Eigenmann, Martin Näf, Peter Ackle, Martin Roth, Christoph Andreas Fux
BACKGROUND: In Switzerland, intravenous drug use accounts for the majority of hepatitis C virus (HCV) infections. Early HCV treatment prevents further transmissions and reduces morbidity and mortality due to decompensated liver cirrhosis and hepatocellular carcinoma. Nevertheless, patients in drug substitution programmes are often insufficiently screened and treated. AIM: The aim was to compare the current state of HCV management in centralised and decentralised drug substitution programmes of the canton Aargau...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29176842/allergenic-food-introduction-and-risk-of-childhood-atopic-diseases
#12
Niels J Elbert, Jessica C Kiefte-de Jong, Trudy Voortman, Tamar E C Nijsten, Nicolette W de Jong, Vincent W V Jaddoe, Johan C de Jongste, Roy Gerth van Wijk, Liesbeth Duijts, Suzanne G M A Pasmans
BACKGROUND: The role of timing and diversity of allergenic food introduction in the development of childhood allergic sensitization and atopic diseases is controversial. OBJECTIVE: To examine whether timing and diversity of allergenic food introduction are associated with allergic sensitization, allergy and eczema in children until age 10 years. MATERIALS AND METHODS: This study among 5,202 children was performed in a population-based prospective cohort...
2017: PloS One
https://www.readbyqxmd.com/read/29176005/could-routine-spirometry-suggest-sensitisation-in-the-military-medicine-setting
#13
Ignazio Cirillo, F Gallo, G Ciprandi
INTRODUCTION: Providing evidence of sensitisation is the formal requirement for allergy diagnosis. The aim of this study was to evaluate whether spirometry may be able to predict sensitisation in a representative cohort of Italian Navy military personnel. METHODS: 2043 (1875 men, 168 women, mean age 28.35±11.6 years) Italian Navy military personnel were enrolled into this study. Spirometry and skin prick testing were performed to predict sensitisation. RESULTS: Sensitisation, assessed by skin prick test, was documented in 658 (32...
November 24, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29175989/3-bromomethyl-2-chloro-4-methylsulfonyl-benzoic-acid-a-new-cause-of-sensitiser-induced-occupational-asthma-rhinitis-and-urticaria
#14
Hille Suojalehto, Kirsi Karvala, Saana Ahonen, Katriina Ylinen, Liisa Airaksinen, Katri Suuronen, Sari Suomela, Irmeli Lindström
OBJECTIVES: 3-(Bromomethyl)-2-chloro-4-(methylsulfonyl)-benzoic acid (BCMBA) has not previously been identified as a respiratory sensitiser. We detected two cases who presented respiratory and urticaria symptoms related to BCMBA and had positive skin prick tests to the agent. Subsequently, we conducted outbreak investigations at the BCMBA-producing factory and performed clinical examinations to confirm occupational diseases. METHODS: The outbreak investigations included observations of work processes, assessment of exposure, a medical survey with a questionnaire and skin prick tests with 0...
November 24, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29175280/surfing-as-a-risk-factor-for-sensitization-to-poly-%C3%AE-glutamic-acid-in-fermented-soybeans-natto-allergy
#15
Naoko Inomata, Mami Miyakawa, Michiko Aihara
BACKGROUND: Poly(γ-glutamic acid) (PGA) is an allergen in natto, fermented soybeans, which causes late-onset anaphylaxis. We hypothesized that jellyfish stings sensitize adults to PGA because a surfer had allergies to both natto and jellyfish, whose sting contains PGA. The aim of the study was to identify behavioral factors, such as marine sports, associated with PGA sensitization. METHODS: Outpatients diagnosed with food allergies based on relevant clinical history, positive skin test and/or food challenge test answered a questionnaire during a regular visit in 2016...
November 24, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29175231/field-performance-of-the-determine-hbsag-point-of-care-test-for-diagnosis-of-hepatitis-b-virus-co-infection-among-hiv-patients-in-zambia
#16
Caroline C Chisenga, Kalo Musukuma, Roma Chilengi, Samuel Zürcher, Virginia Munamunungu, Alice Siyunda, David Ojok, Sophie Bauer, Gilles Wandeler, Michael Vinikoor
BACKGROUND: We evaluated the field performance of a rapid point-of-care (POC) test for hepatitis B surface antigen (HBsAg) that could support decentralization and scale-up of hepatitis B virus (HBV) diagnosis in Africa. OBJECTIVE: To determine the field performance of the Determine HBsAg POC test for diagnosis of HBV co-infection among HIV patients in Zambia. STUDY DESIGN: Between 2013-2014, we screened HIV-infected adults for HBsAg at two urban clinics in Zambia...
November 16, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29171912/concomitant-sensitization-to-legumin-fag-e-2-and-fag-e-5-predicts-buckwheat-allergy
#17
S Geiselhart, C Nagl, P Dubiela, A C Pedersen, M Bublin, C Radauer, C Bindslev-Jensen, K Hoffmann-Sommergruber, C G Mortz
BACKGROUND: Buckwheat (Fagopyrum esculentum) has become increasingly popular as a healthy food in Europe. However, for sensitized individuals, consumption can cause anaphylactic reactions. The aim of this study was to identify individual well-characterized buckwheat allergens for component resolved diagnosis. METHODS: Patients were selected by positive skin prick test to buckwheat and divided into two groups: (1) sensitized to buckwheat without clinical symptoms and (2) buckwheat allergy...
November 24, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29171863/schistosoma-mansoni-specific-immune-responses-and-allergy-in-uganda
#18
Gyaviira Nkurunungi, Joyce Kabagenyi, Margaret Nampijja, Richard E Sanya, Bridgious Walusimbi, Jacent Nassuuna, Emily L Webb, Alison M Elliott
Low allergy-related disease (ARD) prevalence in low-income countries may be partly attributed to helminth infections. In the Schistosoma mansoni (Sm)-endemic Lake Victoria islands (Uganda), we recently observed positive helminth-allergy associations, despite low ARD prevalence. To understand how Sm-induced cytokine and antibody profiles might influence allergic response profiles in this population, we assessed Schistosoma worm (SWA)- and egg antigen (SEA)-specific Th1 (IFN-γ), Th2 (IL-5, IL-13) and regulatory (IL-10) cytokine profiles (n=407), and total (n=471), SWA-, SEA- and allergen (house dust mite [HDM] and cockroach)-specific (as)IgE and IgG4 profiles (n=2117) by ELISA...
November 24, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/29171126/coincidence-of-pollen-season-with-the-first-fetal-trimester-together-with-early-pet-exposure-is-associated-with-sensitisation-to-cat-and-dog-allergens-in-early-childhood-a-finnish-population-based-study
#19
Kaisa Pyrhönen, Petri Kulmala, Simo Näyhä
BACKGROUND: Children whose 11th fetal week falls in pollen season (spring) reportedly have an increased risk of sensitisation to food allergens. No such finding has been reported for pet allergens. OBJECTIVE: The aim of the study was to 1) evaluate the incidence of pet (dog and cat) sensitisation according to the season of the 11th fetal week and 2) whether the association between pet exposure and respective sensitisation is modified by the coincidence of the 11th fetal week with pollen season...
November 24, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29169170/mite-induced-asthma-and-ige-levels-to-shrimp-mite-tropomyosin-arginine-kinase-and-der-p-10-are-the-most-relevant-risk-factors-for-challenge-proven-shrimp-allergy
#20
Laura Farioli, Laura Michelina Losappio, Maria Gabriella Giuffrida, Valerio Pravettoni, Gianluigi Micarelli, Michele Nichelatti, Joseph Scibilia, Corrado Mirone, Laura Cavallarin, Cristina Lamberti, Luca Giuseppe Balossi, Elide Anna Pastorello
BACKGROUND: Shrimp sensitization is common in the general population, but the presence of symptoms is only moderately related to sensitization. A point still at issue is which in vivo and/or in vitro tests (food challenge, component-resolved diagnosis, house dust mite [HDM] sensitization) can help in distinguishing shrimp-allergic subjects from subjects that are sensitized but tolerant. METHODS: The aim of this study was to evaluate the role of IgE to the different shrimp and mite allergens in distinguishing shrimp challenge-positive from challenge-negative patients...
November 24, 2017: International Archives of Allergy and Immunology
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