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https://www.readbyqxmd.com/read/29027379/impact-of-omalizumab-in-children-from-a-middle-income-country-with-severe-therapy-resistant-asthma-a-real-life-study
#1
Paulo M Pitrez, Rodrigo G de Souza, Cristian Roncada, Joao P Heinzmann-Filho, Giovana Santos, Leonardo A Pinto, Marcus H Jones, Renato T Stein
BACKGROUND: Severe asthma in children is a global health problem. Severe therapy-resistant asthma (STRA) in children is a major clinical challenge due to persistent symptoms despite high doses of corticosteroids and results in high public health costs. Omalizumab (anti-IgE monoclonal antibody) has been described as an effective add-on therapy in these patients. The characteristics of children with STRA from low- and middle-income countries have scarcely been reported, and no real-life study has been published on the effects of omalizumab in this group of patients...
October 13, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29026294/comparison-of-the-peripheral-blood-eosinophil-count-using-near-patient-testing-and-standard-automated-laboratory-measurement-in-healthy-asthmatic-and-copd-subjects
#2
Kirsty Hambleton, Clare M Connolly, Catherine Borg, Joanne H Davies, Helen P Jeffers, Richard Ek Russell, Mona Bafadhel
Near-patient testing (NPT) allows clinical decisions to be made in a rapid and convenient manner and is often cost effective. In COPD the peripheral blood eosinophil count has been demonstrated to have utility in providing prognostic information and predicting response to treatment during an acute exacerbation. For this potential to be achieved having a reliable NPT of blood eosinophil count would be extremely useful. Therefore, we investigated the use of the HemoCue(®) WBC Diff System and evaluated its sensitivity and specificity in healthy, asthmatic and COPD subjects...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29025431/specific-ige-and-skin-prick-tests-to-diagnose-allergy-to-fresh-and-baked-cow-s-milk-according-to-age-a-systematic-review
#3
REVIEW
Barbara Cuomo, Giovanni Cosimo Indirli, Annamaria Bianchi, Stefania Arasi, Davide Caimmi, Arianna Dondi, Stefania La Grutta, Valentina Panetta, Maria Carmen Verga, Mauro Calvani
BACKGROUND: The diagnosis of IgE-mediated cow's milk allergy is often based on anamnesis, and on specific IgE (sIgE) levels and/or Skin Prick Tests (SPT), which have both a good sensitivity but a low specificity, often causing positive results in non-allergic subjects. Thus, oral food challenge is still the gold standard test for diagnosis, though being expensive, time-consuming and possibly at risk for severe allergic reactions. AIM: The aim of the present study was to perform a systematic review of the studies that have so far analyzed the positive predictive values for sIgE and SPT in the diagnosis of allergy to fresh and baked cow's milk according to age, and to identify possible cut-offs that may be useful in clinical practice...
October 12, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29021189/presence-of-atopy-increases-the-risk-of-asthma-relapse
#4
Laurel Teoh, Ian M Mackay, Peter P Van Asperen, Jason P Acworth, Mark Hurwitz, John W Upham, Weng Hou Siew, Claire Y T Wang, Theo P Sloots, Teresa Neeman, Anne B Chang
OBJECTIVES: To describe the point prevalence of respiratory viruses/atypical bacteria using PCR and evaluate the impact of respiratory viruses/atypical bacteria and atopy on acute severity and clinical recovery in children with hospitalised and non-hospitalised asthma exacerbations. DESIGN: This was a prospective study performed during 2009-2011. SETTING: The study was performed in the emergency departments of two hospitals. PATIENTS: 244 children aged 2-16 years presenting with acute asthma to the emergency departments were recruited...
October 11, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29017483/co-infection-of-schistosoma-mansoni-hepatitis-c-virus-and-their-associated-factors-among-adult-individuals-living-in-fishing-villages-north-western-tanzania
#5
Humphrey D Mazigo, Stella Kepha, Godfrey M Kaatano, Safari M Kinung'hi
BACKGROUND: Schistosoma mansoni and Hepatitis C virus (HCV) are co-existence in sub-Saharan Africa and co-infection is common among humans population. The immunological responses characterized with Th2-immune responses for S. mansoni and Th1-immune responses for HCV are responsible for development hepatic morbidities in infected individuals. However, the co-occurrences of S. mansoni and HCV infection, their related ultrasound detectable morbidities and associated risk factors at community levels have not been examined in fishing communities, north-western Tanzania...
October 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28993393/recurrent-wheeze-and-its-relationship-with-lung-function-and-airway-inflammation-in-preschool-children-a-cross-sectional-study-in-south-korea
#6
Ji Eun Soh, Kyung-Moon Kim, Ji-Won Kwon, Hyung Young Kim, Ju-Hee Seo, Hyo-Bin Kim, So-Yeon Lee, Gwang-Cheon Jang, Dae-Jin Song, Woo Kyung Kim, Young-Ho Jung, Soo-Jong Hong, Jung Yeon Shim
BACKGROUND: Relationship between recurrent wheeze and airway function and inflammation in preschool children is not fully known. OBJECTIVE: To investigate the relationship between recurrent wheeze and airway inflammation, lung function, airway hyper-reactivity (AHR) and atopy in preschool children. DESIGN: Observational study, comparing forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and mid-forced expiratory flow (FEF25%-75%), dose-response slope (DRS), exhaled nitric oxide (eNO) and atopic sensitisation between children with recurrent wheeze and those without...
October 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28984082/performance-evaluation-of-the-microinr-%C3%A2-point-of-care-inr-testing-system
#7
J Joubert, M C van Zyl, J Raubenheimer
INTRODUCTION: Point-of-care International Normalised Ratio (INR) testing is used frequently. We evaluated the microINR(®) POC system for accuracy, precision and measurement repeatability, and investigated instrument and test chip variability and error rates. METHODS: Venous blood INRs of 210 patients on warfarin were obtained with Thromborel(®) S on the Sysmex CS-2100i(®) analyser and compared with capillary blood microINR(®) values. Precision was assessed using control materials...
October 6, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28981975/lung-function-improvement-and-airways-inflammation-reduction-in-asthmatic-children-after-a-rehabilitation-program-at-moderate-altitude
#8
Eugen Bersuch, Florian Gräf, Ellen D Renner, Andreas Jung, Claudia Traidl-Hoffmann, Roger Lauener, Caroline Roduit
BACKGROUND: Rehabilitational programs at moderate altitude (1500m to 2500m) showed improvement of lung function and reduction of airways inflammation in asthmatic adults. Allergen avoidance was postulated as the major cause of these improvements. METHODS: Spirometries of 344 and fractional exhaled nitric oxide measurements (FeNO) of 124 asthmatic children and adolescents, staying in a rehabilitation hospital in Davos (1590m) with at least 14 days between admission and discharge, were analysed in associations with atopic sensitisation (skin-prick testing and/or specific IgE), level of asthma control, and inhalative corticosteroid (ICS) dose...
October 5, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28980879/skin-reactions-to-latex-in-dental-professionals-first-croatian-data
#9
Iva Japundžić, Liborija Lugović-Mihić
PURPOSE: To determine the prevalence of undesirable skin reactions to latex in dental professionals and students of the School of Dental Medicine in Zagreb, Croatia. METHODS: Our research included 444 participants, of which 200 agreed to undergo a skin prick test (SPT). All participants answered a questionnaire in which we asked about incidence of skin lesions, duration of occupational exposure to latex, localization of skin lesions and symptoms. A statistical analysis of the questionnaire and test results was then carried out...
October 5, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28976229/associations-of-atopy-and-asthma-during-aging-of-an-adult-population-over-a-20-year-follow-up
#10
Diogenes S Ferreira, Sonia Kaushik, Catherine L Smith, Shyamali C Dharmage, Geza P Benke, Bruce R Thompson, E Haydn Walters, Rory Wolfe, Michael J Abramson
OBJECTIVE: Atopy is associated with asthma, but cross-sectional studies suggest this association may be weaker in older adults. It remains unclear if atopy predicts asthma later in adult life. We aimed to investigate whether atopy in young adults predicted asthma 20 years later and to quantify the contemporaneous relationship of atopy and asthma as adults age. METHODS: Participants of the European Community Respiratory Health Survey (ECRHS) in [city; data removed for double-blind peer review] aged 20-44 years were followed for 20 years and completed questionnaires, skin prick tests (SPT) and allergen specific immunoglobulin E measurement at a baseline and two subsequent surveys...
October 4, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28972658/atopy-in-people-aged-40-and-over-relation-to-airflow-limitation
#11
Elyse Marie Guevara-Rattray, Frances L Garden, Alan L James, Richard Wood-Baker, Michael J Abramson, David P Johns, A Sonia Buist, Peter G J Burney, E Haydn Walters, Brett G Toelle, Guy B Marks
BACKGROUND: Previous studies have reached conflicting conclusions about the role of atopy as a risk factor for COPD. In part, this is attributable to variation in the definitions of airflow limitation and the treatment of people with asthma. OBJECTIVE: To establish whether there is any independent association between atopy and post-bronchodilator airflow limitation in the general population aged 40 years and over. METHODS: A cross-sectional survey was conducted in a general population sample of 2415 people aged 40 years and over in Australia...
October 3, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28969432/hiv-self-testing-in-lusaka-province-zambia-acceptability-comprehension-of-testing-instructions-and-individual-preferences-for-self-test-kit-distribution-in-a-population-based-sample-of-adolescents-and-adults
#12
Arianna Zanolini, Jenala Chipungu, Michael Vinikoor, Samuel Bosomprah, Mazuba Mafwenko, Charles Holmes, Harsha Thirumurthy
Background We assessed attitudes and preferences towards HIV self-testing (HIVST) among Zambian adolescents and adults. Methods We conducted a population-based survey of individuals aged 16-49 years old in Lusaka Province, Zambia. HIVST was shown to participants through a short video on oral fluid-based self-testing. In addition to demographics, HIV risk perceptions, and HIV testing history, we assessed participants' acceptability and concerns regarding HIVST. Using a discrete choice experiment, we investigated preferences for the location of self-test pickup, availability of counseling, and cost...
October 2, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28969175/pattern-of-allergen-sensitivity-among-patients-with-bronchial-asthma-and-or-allergic-rhinosinusitis-in-a-tertiary-care-centre-of-southern-india
#13
Bharti Chogtu, Neha Magaji, Rahul Magazine, Preetam R Acharya
INTRODUCTION: The distribution of aeroallergens varies among various geographical areas of India and the knowledge of allergen sensitivity pattern in this part of Southern Indian (Karnataka) is limited. This data can provide clinically useful information and better understanding of common allergies prevalent in this area. AIM: To study the pattern of allergen sensitivity among patients with bronchial asthma and/or allergic rhinosinusitis. MATERIALS AND METHODS: In this retrospective study, patients diagnosed with bronchial asthma and/or allergic rhinitis who underwent skin prick testing, were included in the study...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28967612/a-history-of-continuous-glucose-monitors-cgms-in-self-monitoring-of-diabetes-mellitus
#14
REVIEW
David Olczuk, Ronny Priefer
Self-monitoring of glucose for individuals afflicted with diabetes mellitus has allowed patients to take control of their disease and thus directly affect the outcomes related to it. It has been almost a century since the first test to monitor one's sugar was developed; that being a urine test. The most well-known and prominent medical device for monitor blood glucose for individuals with diabetes are the finger-prick devices. This itself is an approximately 50year old technology. More recently has been the introduction of continuous glucose monitors (CGMs) which entered the market place in the last year of the 20th century...
September 22, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28959378/debates-in-allergy-medicine-molecular-allergy-diagnosis-with-isac-will-replace-screenings-by-skin-prick-test-in-the-future
#15
E Jensen-Jarolim, A N Jensen, G W Canonica
In today's clinical practice patients' skin is used as screening organ for diagnosing type 1 allergy. According to European guidelines skin prick testing with a panel of 18 allergen extracts is recommended, in the US between 10 to 50 allergens are used. The specificity and sensitivity of skin testing is individually highly variable depending on age, body mass, and skin barrier status. In atopic inflammation skin testing gives more false positive results. Smaller skin area and strain limits prick testing in small children...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28957644/effect-of-early-life-geohelminth-infections-on-the-development-of-wheezing-at-5-years-of-age
#16
Philip J Cooper, Martha E Chico, Maritza G Vaca, Carlos A Sandoval, Sofia Loor, Leila Amorim, Laura C Rodrigues, Mauricio L Barreto, David P Strachan
RATIONALE: Exposures to geohelminths during gestation or early childhood may reduce risk of wheezing illness/asthma and atopy during childhood in tropical regions. OBJECTIVES: To investigate the effect of maternal and early childhood geohelminths on development of wheeze/asthma and atopy during the first 5 years of life. METHODS: Cohort of 2,404 neonates followed to 5 years of age in rural District in coastal Ecuador. Data on wheeze collected by questionnaire and atopy measured by allergen skin prick test reactivity to 9 allergens at 5 years...
September 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28943471/childhood-chronic-prurigo-interest-of-patch-tests-and-delayed-reading-skin-prick-tests-to-environmental-allergens
#17
Claire Maridet, Martin Perromat, Juliette Miquel, Christine Chiaverini, Didier Bessis, Audrey Lasek, Maryam Piram, Anne-Claire Bursztejn, Claire Abasq, Alice Phan, Ludovic Martin, Bérénice Bréchat, Jin Ho Chong, Julien Seneschal, Alain Taïeb, Franck Boralevi
Childhood chronic prurigo is rarely studied in particular for allergic components. We propose a clinical classification according to seasonality of prurigo in three groups to help identifying causal agents and guide allergy testing with delayed readings tests.
September 21, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28941692/extensive-profiling-of-three-varieties-of-opuntia-spp-fruit-for-innovative-food-ingredients
#18
Bruno Melgar, Eliana Pereira, M Beatriz P P Oliveira, Esperanza M Garcia-Castello, Antonio D Rodriguez-Lopez, Marina Sokovic, Lillian Barros, Isabel C F R Ferreira
Consumer interest in the use of natural ingredients is creating a growing trend in the food industry, leading to research into the development of natural products such as colorants, antimicrobials and antioxidant compounds. This work involves an extensive morphological (using physico-chemical assays), chemical (antioxidant activity assays) and microbiological (Gram-positive and negative strains) characterization of prickly peras (Opuntia ficus-indica (OFI) var. sanguigna, gialla and Opuntia engelmannii) fruits...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28940850/sensitisation-to-fungi-in-atopic-dermatitis-patients-older-14-years-of-age-and-the-relation-to-the-occurrence-of-food-hypersensitivity-reactions
#19
J Čelakovská, J Bukač, K Ettler, J Vaneckova, I Krcmova, K Ettlerova
The aim of this study is the evaluation, if there is some relation between the sensitisation to fungi and the occurrence of food hypersensitivity reactions in atopic dermatitis patients aged 14 years and older. The complete dermatological and allergological examinations were perfomed in all included patients; the occurrence of food hypersensitivity reactions was recorded and the sensitisation to mixture of fungi was examined (skin prick test, specific IgE). The statistical evaluation of the relation between the sensitisation to fungi and the occurrence of food hypersensitivity reactions was performed; 331 patients were included in the study, 110 men and 221 women, the average age 26...
September 22, 2017: Mycoses
https://www.readbyqxmd.com/read/28938843/comparison-of-specific-ige-detection-by-immunoblotting-and-fluorescence-enzyme-assay-with-in-vivo-skin-prick-test
#20
Jongkonnee Wongpiyabovorn, Narissara Suratannon, Sadudee Boonmee, Pantipa Chatchatee
BACKGROUND: Diagnostic tools to identify allergens that cause allergic symptom is important part in the care of allergic patients. Detection of causative allergen can be performed by in vivo skin prick test (SPT) or in vitro tests for detection serum specific immunoglobulin E (sIgE). The common methods used are fluorescent enzyme assay and immunoblotting assay. OBJECTIVE: We aim to evaluate performance of the two sIgE determination systems, immunoblotting assay (Euroline) and fluorescent enzyme assay (ImmunoCAP) in comparison with SPT...
September 17, 2017: Asian Pacific Journal of Allergy and Immunology
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