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Meningococcal vaccinations

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https://www.readbyqxmd.com/read/29329168/immune-responses-to-booster-vaccination-with-meningococcal-abcwy-vaccine-following-primary-vaccination-with-either-investigational-or-licensed-vaccines-a-phase-2-randomized-study
#1
Leszek Szenborn, Stan L Block, Teresa Jackowska, Ryszard Konior, Diego DʼAgostino, Igor Smolenov, Daniela Toneatto, Jo Anne Welsch
BACKGROUND: Current meningococcal prime-boost vaccination schedules include separate vaccines for serogroups ACWY and B. An investigational combined serogroups ABCWY vaccine (MenABCWY) was developed to protect against clinically important Neisseria meningitidis serogroups. METHODS: In this phase 2, randomized, observer-blind, extension study (NCT01272180), participants aged 10-25 years received 1 booster dose of MenABCWY vaccine at 24 months (M) post-primary series of either MenABCWY (2 doses), 4CMenB (2 doses) or MenACWY-CRM vaccine (1 dose)...
January 11, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29325425/meningitis-vaccination-knowledge-and-awareness-among-ymsm-in-chicago
#2
Gregory Phillips, Amy K Johnson, Christian N Adames, Brian Mustanski
Serogroup C invasive meningococcal disease (IMD) outbreaks in men who have sex with men (MSM) have been occurring with greater frequency in urban areas across the United States. An effective vaccine for IMD is available and is recommended for MSM in outbreak settings. Particular subgroups of MSM have been disproportionately represented in outbreaks, specifically young, Black, and HIV-positive MSM. As little is known about the knowledge, awareness, and vaccination status of young MSM, we sought to describe this and explore racial/ethnic differences...
January 1, 2018: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29322575/vaccine-preventable-child-deaths-in-new-south-wales-from-2005-to-2014-how-much-is-preventable
#3
Anastasia Phillips, Frank Beard, Kristine Macartney, Jocelyn Chan, Robin Gilmour, Gemma Saravanos, Peter McIntyre
AIM: To identify and describe potentially vaccine-preventable child deaths in New South Wales (NSW). METHODS: Child deaths in NSW from 2005 to 2014 potentially preventable by vaccination were identified from the NSW Child Death Register (maintained by the NSW Ombudsman) and the Notifiable Conditions Information Management System (NSW Health). Medical and post-mortem records were reviewed. Cases were classified as vaccine-preventable based on the strength of evidence for the relevant infection causing death and likelihood that death was preventable through vaccination...
January 11, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29301718/-immunisation-schedule-of-the-spanish-association-of-paediatrics-2018-recommendations
#4
David Moreno-Pérez, Francisco José Álvarez García, Javier Álvarez Aldeán, María José Cilleruelo Ortega, María Garcés Sánchez, Nuria García Sánchez, Ángel Hernández Merino, María Méndez Hernández, Manuel Merino Moína, Abián Montesdeoca Melián, Jesús Ruiz-Contreras
The Advisory Committee on Vaccines of the Spanish Association of Paediatrics annually publishes the immunisation schedule considered optimal for children resident in Spain, according to available evidence on current vaccines. Regarding funded immunisations, 2+1 strategy (2, 4, 11-12 months) with hexavalent (DTPa-IPV-Hib-HB) and 13-valent pneumococcal vaccines are recommended. Administration of the 6-year booster dose with DTPa is recommended, and a poliomyelitis dose for children who had received the 2+1 scheme, as well as Tdap vaccine for adolescents and pregnant women in every pregnancy between 27 and 32 weeks' gestation...
January 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29290234/bacterial-meningitis-antibiotic-treatment
#5
R Cohen, J Raymond, L Hees, D Pinquier, E Grimprel, C Levy
The implementation of pneumococal conjugate vaccines (PCVs) 7 then 13 valent (Prevenar13®) in 2010-2011 has significantly changed the profile of pneumococcal meningitis. Since 3 years, the National Pediatric Meningitis Network of the Pediatric Infectious Disease Group (GPIP) and the National Reference Centre of Pneumococci have reported no cases of meningitis due to pneumococcus resistant to third-generation cephalosporins (3GC): cefotaxime or ceftriaxone. In the light of these new data, vancomycin should no longer be prescribed at the initial phase of pneumococcal meningitis treatment (confirmed or only suspected) and this antibiotic should only be added when 3GC minimum inhibitory concentration of the strain isolated is greater than 0...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29287771/lower-antibody-functionality-in-middle-aged-adults-compared-to-adolescents-after-primary-meningococcal-vaccination-role-of-igm
#6
Marieke van der Heiden, Mariette B van Ravenhorst, Marjan Bogaard, Annemieke M H Boots, Guy A M Berbers, Anne-Marie Buisman
INTRODUCTION: Successful vaccination of elderly persons is often hampered by immunological ageing, leaving part of the elderly population vulnerable for infectious diseases. As an alternative, timely vaccinations might be administered at middle-age, before reaching old age. Studies evaluating the immunological fitness of middle-aged adults are warranted. In this study we compared the immunogenicity of a primary meningococcal vaccination in Dutch middle-aged adults with that in adolescents, in order to gain knowledge on the early signs of immune ageing...
December 26, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29287682/development-of-an-fhbp-ctb-holotoxin-like-chimera-and-the-elicitation-of-bactericidal-antibodies-against-serogroup-b-neisseria-meningitidis
#7
Gregory A Price, Margaret C Bash
The Neisseria meningitidis factor H binding protein (FHbp) is an important virulence factor and vaccine antigen contained in both USA licensed serogroup B meningococcal vaccines. Recent studies in human factor H (hFH) transgenic mice suggest that hFH-FHbp interactions lower FHbp-elicited immunogenicity. To provide tools with which to characterize and potentially improve FHbp immunogenicity, we developed an FHbp-cholera holotoxin-like chimera vaccine expression system in Escherichia coli that utilizes cholera toxin B (CTB) as both a scaffold and adjuvant for FHbp...
December 26, 2017: Vaccine
https://www.readbyqxmd.com/read/29246475/estimating-primary-care-attendance-rates-for-fever-in-infants-after-meningococcal-b-vaccination-in-england-using-national-syndromic-surveillance-data
#8
Sally Harcourt, Roger A Morbey, Chris Bates, Helen Carter, Shamez N Ladhani, Simon de Lusignan, Gillian E Smith, Alex J Elliot
BACKGROUND: In September 2015, the United Kingdom became the first country to introduce the multicomponent group B meningococcal vaccine (4CMenB) into a national infant immunisation programme. In early clinical trials 51-61% of infants developed a fever when 4CMenB was administered with other routine vaccines. Whilst administration of prophylactic paracetamol is advised, up to 3% of parents may seek medical advice for fever following vaccination. We used research-level general practitioner consultations to identify any increase in attendances for all-cause fever in vaccine-eligible infants following 4CMenB introduction in England...
December 12, 2017: Vaccine
https://www.readbyqxmd.com/read/29240724/large-outbreak-of-neisseria-meningitidis-serogroup-c-nigeria-december-2016-june-2017
#9
Chimeremma Nnadi, John Oladejo, Sebastian Yennan, Adesola Ogunleye, Chidinma Agbai, Lawal Bakare, Mohammed Abdulaziz, Amina Mohammed, Mary Stephens, Kyadindi Sumaili, Olivier Ronveaux, Helen Maguire, Debra Karch, Mahmood Dalhat, Martin Antonio, Andre Bita, Ifeanyi Okudo, Patrick Nguku, Ryan Novak, Omotayo Bolu, Faisal Shuaib, Chikwe Ihekweazu
On February 16, 2017, the Ministry of Health in Zamfara State, in northwestern Nigeria, notified the Nigeria Centre for Disease Control (NCDC) of an increased number of suspected cerebrospinal meningitis (meningitis) cases reported from four local government areas (LGAs). Meningitis cases were subsequently also reported from Katsina, Kebbi, Niger, and Sokoto states, all of which share borders with Zamfara State, and from Yobe State in northeastern Nigeria. On April 3, 2017, NCDC activated an Emergency Operations Center (EOC) to coordinate rapid development and implementation of a national meningitis emergency outbreak response plan...
December 15, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29236639/a-bivalent-meningococcal-b-vaccine-in-adolescents-and-young-adults
#10
RANDOMIZED CONTROLLED TRIAL
Lars Ostergaard, Timo Vesikari, Judith Absalon, Johannes Beeslaar, Brian J Ward, Shelly Senders, Joseph J Eiden, Kathrin U Jansen, Annaliesa S Anderson, Laura J York, Thomas R Jones, Shannon L Harris, Robert O'Neill, David Radley, Roger Maansson, Jean-Louis Prégaldien, John Ginis, Nina B Staerke, John L Perez
BACKGROUND: MenB-FHbp is a licensed meningococcal B vaccine targeting factor H-binding protein. Two phase 3 studies assessed the safety of the vaccine and its immunogenicity against diverse strains of group B meningococcus. METHODS: We randomly assigned 3596 adolescents (10 to 18 years of age) to receive MenB-FHbp or hepatitis A virus vaccine and saline and assigned 3304 young adults (18 to 25 years of age) to receive MenB-FHbp or saline at baseline, 2 months, and 6 months...
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29236585/impact-of-meningococcal-c-conjugate-vaccination-programs-with-and-without-catch-up-campaigns-in-adolescents-lessons-learned-from-bahia-brazil
#11
Lara Evellyn do, Viviane Ferreira, Caroline Feitosa, Amelia Nunes, Leila Campos, Marco Aurélio P Sáfadi
The significant increase in the incidence rates and ongoing outbreaks of serogroup C meningococcal (MenC) disease, associated with the sequence type-103 complex, motivated the incorporation of the meningococcal C conjugate (MCC) vaccine in the routine immunization program in the State of Bahia, Brazil in early 2010, targeting children younger than 5 years of age. In its capital, Salvador, the program also included a catch-up campaign for individuals 10-24 years of age. We performed an observational, ecological study, analyzing data collected from 2007 to 2015, to compare the impact of these two immunization strategies on meningococcal disease incidence and mortality rates...
December 13, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29228283/interaction-of-neisseria-meningitidis-group-x-n-acetylglucosamine-1-phosphotransferase-with-its-donor-substrate
#12
Shonoi A Ming, Ebony Cottman-Thomas, Natalee C Black, Yi Chen, Vamsee Veeramachineni, Dwight C Peterson, Xi Chen, Lauren M Tedaldi, Gerd K Wagner, Chao Cai, Robert J Linhardt, Willie F Vann
Neisseria meningitidis Group X is an emerging cause of bacterial meningitis in the Sub-Saharan Africa. The capsular polysaccharide of Group X is a homopolymer of N-acetylglucosamine α(1-4) phosphate and is a vaccine target for prevention of disease associated with this meningococcal serogroup. We have demonstrated previously that the formation of the polymer is catalyzed by a phosphotransferase which transfers N- acetylglucosamine-1-phosphate from UDP-N-acetylglucosamine to the 4- hydroxyl of the N-acetylglucosamine on the non-reducing end of the growing chain...
December 8, 2017: Glycobiology
https://www.readbyqxmd.com/read/29227467/evidence-for-rise-in-meningococcal-serogroup-c-bactericidal-antibody-titers-in-the-absence-of-booster-vaccination-in-previously-vaccinated-children
#13
Al-Mamoon Badahdah, Ameneh Khatami, Mohamed Tashani, Harunor Rashid, Robert Booy
BACKGROUND: The introduction of meningococcal serogroup C (MenC) conjugate (MCC) vaccines in the UK and Australia led to an impressive decline in the incidence of invasive disease. This study examined bactericidal antibody titres over time in UK and Australian children who received a MCC vaccine in early childhood to test the hypothesis that ongoing boosting of immunity in the absence of further doses of vaccine in some children may contribute to ongoing protection from disease. METHODS: Serum bactericidal assay using rabbit complement (rSBA) titres at each follow-up visit were compared to all preceding visits to identify any ≥4-fold rise in titres...
December 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29211624/vaccine-prevention-of-meningococcal-disease-in-africa-major-advances-remaining-challenges
#14
Mustapha M Mustapha, Lee H Harrison
Africa historically has had the highest incidence of meningococcal disease with high endemic rates and periodic epidemics. The meningitis belt, a region of sub-Saharan Africa extending from Senegal to Ethiopia, has experienced large, devastating epidemics. However, dramatic shifts in the epidemiology of meningococcal disease have occurred recently. For instance, meningococcal capsular group A (NmA) epidemics in the meningitis belt have essentially been eliminated by use of conjugate vaccine. However, NmW epidemics have emerged and spread across the continent since 2000; NmX epidemics have occurred sporadically, and NmC recently emerged in Nigeria and Niger...
December 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29203096/meningococcal-disease-a-clinical-and-epidemiological-review
#15
REVIEW
Rodrigo Siqueira Batista, Andréia Patrícia Gomes, Jorge Luiz Dutra Gazineo, Paulo Sérgio Balbino Miguel, Luiz Alberto Santana, Lisa Oliveira, Mauro Geller
Meningococcal disease is the acute infection caused by Neisseria meningitidis, which has humans as the only natural host. The disease is widespread around the globe and is known for its epidemical potential and high rates of lethality and morbidity. The highest number of cases of the disease is registered in the semi-arid regions of sub-Saharan Africa. In Brazil, it is endemic with occasional outbreaks, epidemics and sporadic cases occurring throughout the year, especially in the winter. The major epidemics of the disease occurred in Brazil in the 70's caused by serogroups A and C...
November 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29202798/intention-to-vaccinate-universally-against-varicella-rotavirus-gastroenteritis-meningococcal-b-disease-and-seasonal-influenza-among-parents-in-the-netherlands-an-internet-survey
#16
Alies van Lier, José A Ferreira, Liesbeth Mollema, Elisabeth A M Sanders, Hester E de Melker
OBJECTIVE: For the decision-making process regarding introduction of new vaccines into the National Immunisation Programme (NIP), advance insight into the potential acceptance among the population is relevant. We studied the intention of parents to have their child vaccinated against four diseases not currently covered by the NIP in the Netherlands. The results on varicella have been published before; this article adds the results on vaccination against rotavirus gastroenteritis, meningococcal B disease, and seasonal influenza...
December 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29200041/meningococcal-disease-vaccines-who-s-at-risk-and-the-future
#17
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/29200035/meningococcal-disease-vaccines-who-s-at-risk-and-the-future
#18
Patricia Anne O'Malley
No abstract text is available yet for this article.
January 2018: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/29197599/meningococcal-carriage-within-households-in-the-african-meningitis-belt-a-longitudinal-pilot-study
#19
Nicole E Basta, Abdoulaye Berthe, Mahamadou Keita, Uma Onwuchekwa, Boubou Tamboura, Awa Traore, Musa Hassan-King, Olivier Manigart, Maria Nascimento, James M Stuart, Caroline Trotter, Jayne Blake, Anthony D Carr, Stephen J Gray, Lynne S Newbold, Yangqing Deng, Julian Wolfson, M Elizabeth Halloran, Brian Greenwood, Ray Borrow, Samba O Sow
OBJECTIVES: Carriers of Neisseria meningitidis are a key source of transmission. In the African meningitis belt, where risk of meningococcal disease is highest, a greater understanding of meningococcal carriage dynamics is needed. METHODS: We randomly selected an age-stratified sample of 400 residents from 116 households in Bamako, Mali, and collected pharyngeal swabs in May 2010. A month later, we enrolled all 202 residents of 20 of these households (6 with known carriers) and collected swabs monthly for 6 months prior to MenAfriVac vaccine introduction and returned 10 months later to collect swabs monthly for 3 months...
November 29, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29194013/public-policy-for-meningococcal-vaccination
#20
J Claire Cameron
No abstract text is available yet for this article.
December 1, 2017: Human Vaccines & Immunotherapeutics
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