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coinfection parvovirus b19

Sneha Somasekar, Deanna Lee, Jody Rule, Samia N Naccache, Mars Stone, Michael P Busch, Corron Sanders, William M Lee, Charles Y Chiu
Background: Twelve percent of all acute liver failure (ALF) cases are of unknown origin, often termed indeterminate. A previously unrecognized hepatotropic virus has been suspected as a potential etiologic agent. Methods: We compared the performance of metagenomic next-generation sequencing (mNGS) with confirmatory nucleic acid testing (NAT) to routine clinical diagnostic testing in detection of known or novel viruses associated with ALF. Serum samples from 204 adult ALF patients collected from 1998 to 2010 as part of a nationwide registry were analyzed...
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Rakesh Agarwal, Rashmi Baid, Rajarshi Datta, Manjari Saha, Nirmalendu Sarkar
No abstract text is available yet for this article.
January 2017: Tropical Parasitology
Barbara Sobala-Szczygieł, Anna Boroń-Kaczmarska, Lucjan Kępa, Barbara Oczko-Grzesik, Damian Piotrowski, Wojciech Stolarz
Parvovirus B19 infection is associated with a broad spectrum of clinical manifestations among which some are well known but others remain controversial. The role of this infection as a cause of acute hepatitis or exacerbation of chronic liver disease requires discussion regarding its significance in a strategy of prevention and treatment of patients with chronic hepatitis. Clinical importance of this infection in patients with chronic hepatitis B treated with pegylated interferon alpha 2a is still unclear but exactly in this population significant complications during treatment may arise...
2016: Przegla̧d Epidemiologiczny
Barbara Sobala-Szczygieł, Anna Boroń-Kaczmarska, Lucjan Kępa, Barbara Oczko-Grzesik, Damian Piotrowski, Wojciech Stolarz
No abstract text is available yet for this article.
2016: Przegla̧d Epidemiologiczny
Warren L Kupin
By definition, viral-associated GN indicates the direct pathogenic relationship between active viral replication and the development of acute GN. This definition is in sharp contrast to the semantic label and pathophysiologic foundation behind postinfectious GN that uniquely develops only during a period of resolved and absent active infection. The primary example of postinfectious GN are the glomerular lesions described after a pharyngeal or cutaneous streptococcal infection and do not represent the clinical or immunologic pattern seen with viral-associated GN...
September 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
Arezoo Aghakhani, Minoo Mohraz, Kayhan Azadmanesh, Saeedeh Moayedi-Nia, Monireh Kazemimanesh, Setareh Mamishi, Mohammad Banifazl, Amitis Ramezani
Recent studies have demonstrated that, in common with other latent viruses, parvovirus B19 infection can be controlled by the host immune response but may persist in some places such as the bone marrow. Persistent B19 infection has been found in both immunocompetent and immunocompromised individuals, such as patients infected with human immunodeficiency virus (HIV). However, there is limited data regarding long-term B19 viremia in HIV patients. In this study, we investigated virological and hematological findings, and also the clinical outcome, of seven cases of HIV/B19 coinfection (confirmed by PCR) after one year...
May 2016: Archives of Virology
Kayhan Azadmanesh, Minoo Mohraz, Monireh Kazemimanesh, Arezoo Aghakhani, Maryam Foroughi, Mohammad Banifazl, Ali Eslamifar, Amitis Ramezani
The human parvovirus B19 (B19) usually causes a subclinical infection in immunocompetent individuals. Whereas immunocompromised individuals such as patients infected with HIV are at risk of persistent anemia due to B19 infection. Only few studies have been carried out on distribution and molecular epidemiology of B19 in Iran. We aimed to determine the frequency and genotype of B19 among Iranian patients infected with HIV. We conducted a survey on 99 HIV patients and 64 healthy controls. IgG and IgM antibodies against B19 were detected by ELISA and B19 DNA was assessed by nested PCR...
July 2015: Journal of Medical Virology
Matthias Karrasch, Jörg Felber, Peter M Keller, Christine Kletta, Renate Egerer, Jürgen Bohnert, Beate Hermann, Wolfgang Pfister, Bernhard Theis, Iver Petersen, Andreas Stallmach, Michael Baier
A case of primary Epstein-Barr virus (EBV) infection/parvovirus B19 reactivation fulfilling five of eight criteria for hemophagocytic lymphohistiocytosis (HLH) is presented. Despite two coinciding viral infections, massive splenomegaly, and fulminant hepatitis, the patient had a good clinical outcome, probably due to an early onset form of HLH with normal leukocyte count, normal natural killer (NK) cell function, and a lack of hemophagocytosis.
November 2014: International Journal of Infectious Diseases: IJID
Andrea Frustaci, Nicola Petrosillo, Dario Vizza, Marco Francone, Roberto Badagliacca, Romina Verardo, Francesco Fedele, Giuseppe Ippolito, Cristina Chimenti
BACKGROUND: Right ventricle compromise affects survival of patients with HIV-associated pulmonary artery hypertension (PAH). DESIGN: Myocardial histology with viral assessment may clarify the mechanism of right ventricular deterioration and provide clues on PAH origin. METHODS: Fifteen patients with HIV infection, PAH and right ventricular dysfunction underwent cardiac magnetic resonance, catheterization, coronary with ventricular angiography and biventricular endomyocardial biopsy...
November 13, 2014: AIDS
Srikant R Gadwalkar, D V Deepa, Anand Katageri, P Rama Murthy, Ravi Dhar
INTRODUCTION: Persons with HIV infection frequently present with anaemia from different causes, including use of antiretroviral therapy (typically zidovudine), iron deficiency, vitamin B12 deficiency, opportunistic infections (such as mycobacterial and fungal infections), chronic disease, AIDS-associated malignancies, autoimmune haemolysis, and direct effects of HIV infection itself. Persistent infection with Parvovirus B19 (B19) is an important treatable cause of anaemia in HIV-infected patients...
December 2013: Journal of the Association of Physicians of India
C-Thomas Bock, Anja Düchting, Friederike Utta, Eva Brunner, Bui Tien Sy, Karin Klingel, Florian Lang, Meinrad Gawaz, Stephan B Felix, Reinhard Kandolf
AIM: To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy (DCM). METHODS: Endomyocardial biopsies (EMBs) from 498 B19V-positive patients with myocarditis and DCM were analyzed using molecular methods and functional experiments. EMBs were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology centers. Control tissues were obtained at autopsy from 34 victims of accidents, crime or suicide...
April 26, 2014: World Journal of Cardiology
J Kishore, D Kishore
Hemophagocytic lymphohistiocytosis (HLH) triggered by Parvovirus B19 and Epstein-Barr virus co-infection is rare and unknown in infants. A 2-month-old male infant with fever, rash, bicytopenia and hepato-splenomegaly died owing to diagnostic dilemmas. Hence simply testing for hyperferritinaemia and hypertriglyceridemia/hypofibrinogenemia could diagnose HLH early while robust treatment be life-saving.
April 2014: Indian Journal of Medical Microbiology
Chhagan Bihari, Archana Rastogi, Priyanka Saxena, Devraj Rangegowda, Ashok Chowdhury, Nalini Gupta, Shiv Kumar Sarin
Parvovirus B19 infection can present with myriads of clinical diseases and syndromes; liver manifestations and hepatitis are examples of them. Parvovirus B19 hepatitis associated aplastic anemia and its coinfection with other hepatotropic viruses are relatively underrecognized, and there is sufficient evidence in the literature suggesting that B19 infections can cause a spectrum of liver diseases from elevation of transaminases to acute hepatitis to fulminant liver failure and even chronic hepatitis. It can also cause fatal macrophage activation syndrome and fibrosing cholestatic hepatitis...
2013: Hepatitis Research and Treatment
Nicolas Lévêque, Jérôme Legoff, Catherine Mengelle, Séverine Mercier-Delarue, Yohan N'guyen, Fanny Renois, Fabien Tissier, François Simon, Jacques Izopet, Laurent Andréoletti
Viruses are the leading cause of central nervous system (CNS) infections, ahead of bacteria, parasites, and fungal agents. A rapid and comprehensive virologic diagnostic testing method is needed to improve the therapeutic management of hospitalized pediatric or adult patients. In this study, we assessed the clinical performance of PCR amplification coupled with electrospray ionization-time of flight mass spectrometry analysis (PCR-MS) for the diagnosis of viral CNS infections. Three hundred twenty-seven cerebrospinal fluid (CSF) samples prospectively tested by routine PCR assays between 2004 and 2012 in two university hospital centers (Toulouse and Reims, France) were retrospectively analyzed by PCR-MS analysis using primers targeted to adenovirus, human herpesviruses 1 to 8 (HHV-1 to -8), polyomaviruses BK and JC, parvovirus B19, and enteroviruses (EV)...
January 2014: Journal of Clinical Microbiology
Rui Tong, Wei-Min Zhou, Xi-Jun Liu, Yue Wang, Yong-Liang Lou, Wen-Jie Tan
OBJECTIVE: To analyze the infection of human parvovirus B19, human bocavirus (HBoV) and human parvovirus 4 (PARV4) in blood samples among patients with liver disease in Nanjing by molecular detection. METHODS: Nested PCR assays were designed and validated to detect B19, HBoV and PARV4, respectively. The assays were used to screen three parvoviruses in blood samples from 95 patients with different liver disease in Nanjing. The parvovirus infection was analyzed statistically...
April 2013: Chinese Journal of Experimental and Clinical Virology
Aurore Desmons, Caroline Terrade, Camille Boulagnon, Delphine Giusti, Yohan Nguyen, Laurent Andreoletti, Paul Fornes, Beatrice Digeon, Nicolas Leveque
BACKGROUND: An autopsy case of a two-month-old male infant who suddenly and unexpectedly died during his sleep, eight days after the onset of benign varicella. OBJECTIVES: To describe post-mortem combined histological and tissue molecular biological techniques for the diagnosis of cytomegalovirus and varicella zoster virus co-infection as a cause of death. STUDY DESIGN: Real-time quantitative PCR and RT-PCR assays for Herpesviruses, respiratory viruses, Adenovirus, Enterovirus and Parvovirus B19 were performed on multi-organ frozen samples and paraffin-embedded tissues in combination with histology...
October 2013: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Nguyen L Toan, Bui T Sy, Le H Song, Hoang V Luong, Nguyen T Binh, Vu Q Binh, Reinhard Kandolf, Thirumalaisamy P Velavan, Peter G Kremsner, C-Thomas Bock
BACKGROUND: High seroprevalence of parvovirus B19 (B19V) coinfection with Plasmodium falciparum has been previously reported. However, the impact of B19V-infection on the clinical course of malaria is still elusive. In this study, we investigated the prevalence and clinical significance of B19V co-infection in Gabonese children with malaria. METHODS: B19V prevalence was analyzed in serum samples of 197 Gabonese children with P. falciparum malaria and 85 healthy controls using polymerase chain reaction (PCR), enzyme-linked immunosorbent assay (ELISA), and direct DNA-sequencing...
2013: BMC Infectious Diseases
Kwabena Obeng Duedu, Kwamena William Coleman Sagoe, Patrick Ferdinand Ayeh-Kumi, Raymond Bedu Affrim, Theophilus Adiku
OBJECTIVE: To determin the extent to which parvovirus B19 (B19V) and co-infection of B19V and malaria contribute to risk of anaemia in children. METHODS: B19V DNA and malaria parasites were screened for 234 children at the PML Children's Hospital in Accra. The role of B19V and co-infection with B19V and malaria in anaemia was evaluated by analysing full blood cell counts, malaria and B19V DNA results from these children. RESULTS: The prevalence of B19V, malaria and co-infection with B19V and malaria was 4...
February 2013: Asian Pacific Journal of Tropical Biomedicine
A Horovitz, Zein I El, R Valentino, H Medhaoui, J Inamo
No abstract text is available yet for this article.
September 2012: West Indian Medical Journal
Henriette Schneider, Ortwin Adams, Christel Weiss, Ulrich Merz, Horst Schroten, Tobias Tenenbaum
BACKGROUND: Children with petechial rash are more likely to undergo invasive diagnostics, to be treated with antibiotics for potential bacterial infection and to be hospitalized. However, viruses have also been associated with petechial rash. Nonetheless, a systematic analysis of viral infections with modern available techniques as quantitative real-time polymerase chain reaction in the context of petechial rash is lacking. The purpose of this pediatric study was to prospectively uncover viral pathogens that may promote the emergence of petechiae and to analyze the correlation with the clinical characteristics and course...
May 2013: Pediatric Infectious Disease Journal
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