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JOURNAL ARTICLE
Kenneth H Pearce, Laurie K Overton, Robert T Gampe, George B Barrett, J David Taylor, David D McKee, Nino Campobasso, Robert T Nolte, Robert A Reid
Furin, also called proprotein convertase subtilisin/kexin 3 (PCSK3), is a calcium-dependent serine endoprotease that processes a wide variety of proproteins involved in cell function and homeostasis. Dysregulation of furin has been implicated in numerous disease states, including cancer and fibrosis. Mammalian cell expression of the furin ectodomain typically produces a highly glycosylated, heterogeneous protein, which can make crystallographic studies difficult. Here, the expression and purification of nonglycosylated human furin using the BacMam technology and site-directed mutagenesis of the glycosylation sites is reported...
April 1, 2019: Acta Crystallographica. Section F, Structural Biology Communications
#22
Patricia C Galipeau, Kenji M Oman, Thomas G Paulson, Carissa A Sanchez, Qing Zhang, Jerry A Marty, Jeffrey J Delrow, Mary K Kuhner, Thomas L Vaughan, Brian J Reid, Xiaohong Li
It was highlighted that in the original article [1] the Availability of data and materials section was incorrect.
March 12, 2019: Genome Medicine
#23
MULTICENTER STUDY
Jing Dong, Puya Gharahkhani, Wong-Ho Chow, Marilie D Gammon, Geoffrey Liu, Carlos Caldas, Anna H Wu, Weimin Ye, Lynn Onstad, Lesley A Anderson, Leslie Bernstein, Paul D Pharoah, Harvey A Risch, Douglas A Corley, Rebecca C Fitzgerald, Prasad G Iyer, Brian J Reid, Jesper Lagergren, Nicholas J Shaheen, Thomas L Vaughan, Stuart MacGregor, Sharon Love, Claire Palles, Ian Tomlinson, Ines Gockel, Andrea May, Christian Gerges, Mario Anders, Anne C Böhmer, Jessica Becker, Nicole Kreuser, Rene Thieme, Tania Noder, Marino Venerito, Lothar Veits, Thomas Schmidt, Claudia Schmidt, Jakob R Izbicki, Arnulf H Hölscher, Hauke Lang, Dietmar Lorenz, Brigitte Schumacher, Rupert Mayershofer, Yogesh Vashist, Katja Ott, Michael Vieth, Josef Weismüller, Markus M Nöthen, Susanne Moebus, Michael Knapp, Wilbert H M Peters, Horst Neuhaus, Thomas Rösch, Christian Ell, Janusz Jankowski, Johannes Schumacher, Rachel E Neale, David C Whiteman, Aaron P Thrift
BACKGROUND & AIMS: Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study to determine the associations between circulating concentrations of 25(OH)D and risks of EAC and its precursor, Barrett's esophagus (BE). METHODS: We conducted a Mendelian randomization study using a 2-sample (summary data) approach. Six single-nucleotide polymorphisms (SNPs; rs3755967, rs10741657, rs12785878, rs10745742, rs8018720, and rs17216707) associated with circulating concentrations of 25(OH)D were used as instrumental variables...
October 2019: Clinical Gastroenterology and Hepatology
#24
JOURNAL ARTICLE
Tsz-Kan Ma, Daniel C Elliott, Stephanie Reid, Andrew J P White, Philip J Parsons, Anthony G M Barrett
(+)-Hongoquercin A and B were synthesized from commercially available trans, trans-farnesol in six and eleven steps, respectively, using dual biomimetic strategies with polyketide aromatization and subsequent polyene functionalization from a common farnesyl-resorcylate intermediate. Key steps involve Pd(0)-catalyzed decarboxylative allylic rearrangement of a dioxinone β,δ-diketo ester to a β,δ-diketo dioxinone, which was readily aromatized into the corresponding resorcylate, and subsequent polyene cyclization via enantioselective protonation or regioselective terminal alkene oxidation and cationic cyclization of enantiomerically enriched epoxide to furnish the tetracyclic natural product cores...
November 2, 2018: Journal of Organic Chemistry
#25
JOURNAL ARTICLE
Eric D Goldstein, Lynda Schnusenberg, Lesia Mooney, Carol C Raper, Sheila McDaniel, Dallas A Thorpe, Michelle T Franke, Linda K Anderson, Lynnae L McClure, Misty M Oglesby, Catina Y Lewis, Cammi Velichko, Belinda G Bradley, William W Horn, Ashley N Reid, Jason L Siegel, Rocco Cannistraro, Perry Bechtle, Maria Thereza Barbosa, Scott M Silvers, Benjamin L Brown, William D Freeman, David A Miller, Kevin M Barrett, Josephine F Huang
OBJECTIVE: To reduce door-to-angiographic reperfusion (DTR) time to 120 minutes for patients presenting with acute ischemic stroke attributed to anterior circulation large-vessel occlusion amenable to endovascular mechanical thrombectomy. PATIENTS AND METHODS: Patients treated with mechanical thrombectomy before (April 10, 2015, through April 11, 2016) and after (April 12, 2016, through May 10, 2017) implementation of a multitiered notification system were studied...
June 2018: Mayo Clinic Proceedings. Innovations, Quality & Outcomes
#26
JOURNAL ARTICLE
Edward W Jernigan, P Barrett Honeycutt, J Megan M Patterson, Wayne A Rummings, Donald K Bynum, Reid W Draeger
PURPOSE: Using a cadaveric model simulating clinical situations experienced during open reduction and internal fixation of proximal phalangeal fractures, the aim of this study was to evaluate the relationship between level of training and the rates of short, long, and ideal screw length selection based on depth gauge use without fluoroscopy assistance. METHODS: A dorsal approach to the proximal phalanx was performed on the index, middle, and ring fingers of 4 cadaveric specimens, and 3 drill holes were placed in each phalanx...
May 22, 2018: Journal of Hand Surgery
#27
JOURNAL ARTICLE
Jing Dong, David M Levine, Matthew F Buas, Rui Zhang, Lynn Onstad, Rebecca C Fitzgerald, Douglas A Corley, Nicholas J Shaheen, Jesper Lagergren, Laura J Hardie, Brian J Reid, Prasad G Iyer, Harvey A Risch, Carlos Caldas, Isabel Caldas, Paul D Pharoah, Geoffrey Liu, Marilie D Gammon, Wong-Ho Chow, Leslie Bernstein, Nigel C Bird, Weimin Ye, Anna H Wu, Lesley A Anderson, Stuart MacGregor, David C Whiteman, Thomas L Vaughan, Aaron P Thrift
BACKGROUND & AIMS: Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci for esophageal adenocarcinoma (EA) and Barrett's esophagus (BE). However, variants in these loci account for a small fraction of cases of EA and BE. Genetic factors might interact with environmental factors to affect risk of EA and BE. We aimed to identify single nucleotide polymorphisms (SNPs) that may modify the associations of body mass index (BMI), smoking, and gastroesophageal reflux disease (GERD), with risks of EA and BE...
October 2018: Clinical Gastroenterology and Hepatology
#28
JOURNAL ARTICLE
Patricia C Galipeau, Kenji M Oman, Thomas G Paulson, Carissa A Sanchez, Qing Zhang, Jerry A Marty, Jeffrey J Delrow, Mary K Kuhner, Thomas L Vaughan, Brian J Reid, Xiaohong Li
BACKGROUND: Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to protect against tetraploidy, aneuploidy, and chromosomal alterations in the metaplastic condition Barrett's esophagus (BE) and to lower the incidence and mortality of esophageal adenocarcinoma (EA). The esophagus is exposed to both intrinsic and extrinsic mutagens resulting from gastric reflux, chronic inflammation, and exposure to environmental carcinogens such as those found in cigarettes...
February 27, 2018: Genome Medicine
#29
JOURNAL ARTICLE
Pierre Martinez, Diego Mallo, Thomas G Paulson, Xiaohong Li, Carissa A Sanchez, Brian J Reid, Trevor A Graham, Mary K Kuhner, Carlo C Maley
The low risk of progression of Barrett's esophagus (BE) to esophageal adenocarcinoma can lead to over-diagnosis and over-treatment of BE patients. This may be addressed through a better understanding of the dynamics surrounding BE malignant progression. Although genetic diversity has been characterized as a marker of malignant development, it is still unclear how BE arises and develops. Here we uncover the evolutionary dynamics of BE at crypt and biopsy levels in eight individuals, including four patients that experienced malignant progression...
February 23, 2018: Nature Communications
#30
S Jo, J H Lee, J J Mattei, D M Barrett, P van den Elzen, S A Grupp, G S D Reid, A E Seif
This corrects the article DOI: 10.1038/leu.2017.290.
February 2018: Leukemia
#31
MULTICENTER STUDY
Jing Dong, Matthew F Buas, Puya Gharahkhani, Bradley J Kendall, Lynn Onstad, Shanshan Zhao, Lesley A Anderson, Anna H Wu, Weimin Ye, Nigel C Bird, Leslie Bernstein, Wong-Ho Chow, Marilie D Gammon, Geoffrey Liu, Carlos Caldas, Paul D Pharoah, Harvey A Risch, Prasad G Iyer, Brian J Reid, Laura J Hardie, Jesper Lagergren, Nicholas J Shaheen, Douglas A Corley, Rebecca C Fitzgerald, David C Whiteman, Thomas L Vaughan, Aaron P Thrift
BACKGROUND & AIMS: We developed comprehensive models to determine risk of Barrett's esophagus (BE) or esophageal adenocarcinoma (EAC) based on genetic and non-genetic factors. METHODS: We used pooled data from 3288 patients with BE, 2511 patients with EAC, and 2177 individuals without either (controls) from participants in the international Barrett's and EAC consortium as well as the United Kingdom's BE gene study and stomach and esophageal cancer study. We collected data on 23 genetic variants associated with risk for BE or EAC, and constructed a polygenic risk score (PRS) for cases and controls by summing the risk allele counts for the variants weighted by their natural log-transformed effect estimates (odds ratios) extracted from genome-wide association studies...
April 2018: Gastroenterology
#32
JOURNAL ARTICLE
S Jo, J H Lee, J J Mattei, D M Barrett, P van den Elzen, S A Grupp, G S D Reid, A E Seif
No abstract text is available yet for this article.
February 2018: Leukemia
#33
RANDOMIZED CONTROLLED TRIAL
Peter Tyrer, Paul Salkovskis, Helen Tyrer, Duolao Wang, Michael J Crawford, Simon Dupont, Sylvia Cooper, John Green, David Murphy, Georgina Smith, Sharandeep Bhogal, Shaeda Nourmand, Valentina Lazarevic, Gemma Loebenberg, Rachel Evered, Stephanie Kings, Antoinette McNulty, Yvonne Lisseman-Stones, Sharon McAllister, Kofi Kramo, Jessica Nagar, Steven Reid, Rahil Sanatinia, Katherine Whittamore, Gemma Walker, Aaron Philip, Hilary Warwick, Sarah Byford, Barbara Barrett
BACKGROUND: Health anxiety is an under-recognised but frequent cause of distress that is potentially treatable, but there are few studies in secondary care. OBJECTIVE: To determine the clinical effectiveness and cost-effectiveness of a modified form of cognitive-behaviour therapy (CBT) for health anxiety (CBT-HA) compared with standard care in medical outpatients. DESIGN: Randomised controlled trial. SETTING: Five general hospitals in London, Middlesex and Nottinghamshire...
September 2017: Health Technology Assessment: HTA
#34
JOURNAL ARTICLE
R Reid Harvey, Cindy R Friedman, Stacy M Crim, Michael Judd, Kelly A Barrett, Beth Tolar, Jason P Folster, Patricia M Griffin, Allison C Brown
Salmonella enterica serotype Dublin is a cattle-adapted bacterium that typically causes bloodstream infections in humans. To summarize demographic, clinical, and antimicrobial drug resistance characteristics of human infections with this organism in the United States, we analyzed data for 1968-2013 from 5 US surveillance systems. During this period, the incidence rate for infection with Salmonella Dublin increased more than that for infection with other Salmonella. Data from 1 system (FoodNet) showed that a higher percentage of persons with Salmonella Dublin infection were hospitalized and died during 2005-2013 (78% hospitalized, 4...
September 2017: Emerging Infectious Diseases
#35
LETTER
Jeremy M Levin, Steven H Holtzman, John Maraganore, Paul J Hastings, Ron Cohen, Bassil Dahiyat, Julian Adams, Chris Adams, Brett Ahrens, Jeff Albers, Mara G Aspinall, James E Audia, Martin Babler, Peter Barrett, Zoe Barry, Nessan Bermingham, Stephen Bloch, Robert I Blum, Paul B Bolno, Michael W Bonney, Bruce Booth, Daniel M Bradbury, Steven K Brauer, Brook Byers, Pablo J Cagnoni, Brian M Cali, Isaac Ciechanover, Chip Clark, Michael D Clayman, Jeff L Cleland, Paula Cobb, Ron Cooper, Mark G Currie, John Diekman, Eric L Dobmeier, Doug Doerfler, Elizabeth Lr Donley, Deborah Dunsire, Matthew During, Jens W Eckstein, Eric Elenko, Neil A Exter, Jonathan J Fleming, Gregory J Flesher, Jean-Francois Formela, Robert Forrester, Cedric Francois, Heather Franklin, Mason W Freeman, Howard Furst, Leonard Patrick Gage, Nicholas Galakatos, Brian M Gallagher, James A Geraghty, Simba Gill, David V Goeddel, Mark A Goldsmith, Maxine Gowen, Vikas Goyal, Tom Graney, David Grayzel, Barry Greene, Paul Grint, J C Gutierrez-Ramos, Bill Haney, Tuan Ha-Ngoc, Tim Harris, Faheem Hasnain, Yujiro Steve Hata, Peter Hecht, Leslie Henshaw, Rich Heyman, Herve Hoppenot, H Robert Horvitz, Thomas E Hughes, Wende S Hutton, Stephen T Isaacs, Annalisa Jenkins, Jeff Jonker, Jeff Kaplan, Perry Karsen, Jeb Keiper, Jean Kim, Jeff Kindler, Rachel King, Vanessa King, Nina Kjellson, Scott Koenig, Gerhard Koenig, Peter Kolchinsky, Paul Laikind, Robert Bob Langer, John J Lee, Jonathan S Leff, Bruce A Leicher, Nick Leschly, Andrew Levin, Mark Levin, Arnold J Levine, Alan Levy, David R Liu, Harvey F Lodish, Uri Lopatin, Ted W Love, Guy Macdonald, Gail J Maderis, Ankit Mahadevia, Nagesh K Mahanthappa, Joel F Martin, Alex Martin, W Eddie Martucci, James G McArthur, Corey M McCann, Sean A McCarthy, C Geoffrey McDonough, John Mendlein, Larry Miller, Diego Miralles, Kenneth I Moch, Bob More, Andrew G Myers, Michael A Narachi, Amir Nashat, Wendy Nelson, William J Newell, Bernat Olle, John E Osborn, Julia C Owens, Atul Pande, Stelios Papadopoulos, H Stewart Parker, Kush M Parmar, Matthew R Patterson, Steve M Paul, Rob Perez, Matthew Perry, Cary G Pfeffer, Mike Powell, Mark Pruzanski, Dennis J Purcell, Amit Rakhit, Kartik Ramamoorthi, William Rastetter, Adrian Ad Rawcliffe, Laurence E Reid, Ron C Renaud, Jason P Rhodes, William J Rieflin, Chad Robins, Scott M Rocklage, Michael Rosenblatt, Jonathan G Rosin, William J Rutter, Saurabh Saha, Camille Samuels, Vicki L Sato, George Scangos, John A Scarlett, David Schenkein, Stuart L Schreiber, Andrew Schwab, Paul Sekhri, Rajeev Shah, Thomas Shenk, Clay B Siegall, Nick J Simon, Nancy Simonian, Jeff Stein, Michael Su, Mary T Szela, Marco Taglietti, Nina Tandon, Henri Termeer, Nancy A Thornberry, Martin Tolar, Richard Ulevitch, Akshay K Vaishnaw, Anne VanLent, Martin Varsavsky, George P Vlasuk, Michel Vounatsos, Samuel G Waksal, Neil Warma, Ryan J Watts, Yaron Werber, Christoph Westphal, Wendell Wierenga, Doug E Williams, Lewis Rusty Williams, Kleanthis G Xanthopoulos, Daphne Zohar, Sandford Sandy Zweifach
No abstract text is available yet for this article.
March 7, 2017: Nature Biotechnology
#36
JOURNAL ARTICLE
P Barrett Honeycutt, Edward W Jernigan, Wayne A Rummings, Peter J Stern, Reid W Draeger
PURPOSE: To investigate the anatomy of the volar surface of the proximal phalanx of the hand, specifically the longitudinal groove running along the volar phalangeal shaft. METHODS: We measured skeletonized proximal phalanges from 10 embalmed human cadaver hands at 5 equidistant points along the shaft. The difference between the maximum dorsal-palmar thickness of the shaft and thickness measured from the center of the volar groove to the most dorsal aspect of the phalanx indicated the depth of the groove at each point...
March 2017: Journal of Hand Surgery
#37
JOURNAL ARTICLE
Matthew F Buas, Haiwei Gu, Danijel Djukovic, Jiangjiang Zhu, Lynn Onstad, Brian J Reid, Daniel Raftery, Thomas L Vaughan
INTRODUCTION/OBJECTIVES: Incidence of esophageal adenocarcinoma (EA), an often fatal cancer, has increased sharply over recent decades. Several important risk factors (reflux, obesity, smoking) have been identified for EA and its precursor, Barrett's esophagus (BE), but a key challenge remains identifying individuals at highest risk, since most with reflux do not develop BE, and most with BE do not progress to cancer. Metabolomics represents an emerging approach for identifying novel biomarkers associated with cancer development...
March 2017: Metabolomics: Official Journal of the Metabolomic Society
#38
LETTER
M Fidanza, A E Seif, A DeMicco, N Rolf, S Jo, B Yin, Y Li, D M Barrett, J Duque-Afonso, M L Cleary, C H Bassing, S A Grupp, G S D Reid
No abstract text is available yet for this article.
October 2016: Leukemia
#39
JOURNAL ARTICLE
Brian J Reid
The article by Banerjee and colleagues published in this issue of the journal involving a randomized control prevention trial of ursodeoxycholic acid (UDCA) in Barrett esophagus reported a null outcome despite being well designed and executed. Possible reasons for this null outcome are discussed focusing on use of surrogate endpoints in the trial. The trial is especially topical because it comes at a time when there are calls for a Pre-Cancer Genome Atlas (PCGA) for "understanding the earliest molecular and cellular events associated with cancer initiation…" This commentary discusses current concepts in prevention research including branched evolution that leads to therapeutic resistance...
July 2016: Cancer Prevention Research
#40
JOURNAL ARTICLE
Michael F Vaezi, Joel V Brill, Michael R Mills, Brett B Bernstein, Reid M Ness, William O Richards, Lili Brillstein, Rebecca Leibowitz, Ken Strople, Elizabeth A Montgomery, Kavita Patel
No abstract text is available yet for this article.
April 2016: Gastroenterology
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