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Barrett and Reid

Jeremy M Levin, Steven H Holtzman, John Maraganore, Paul J Hastings, Ron Cohen, Bassil Dahiyat, Julian Adams, Chris Adams, Brett Ahrens, Jeff Albers, Mara G Aspinall, James E Audia, Martin Babler, Peter Barrett, Zoe Barry, Nessan Bermingham, Stephen Bloch, Robert I Blum, Paul B Bolno, Michael W Bonney, Bruce Booth, Daniel M Bradbury, Steven K Brauer, Brook Byers, Pablo J Cagnoni, Brian M Cali, Isaac Ciechanover, Chip Clark, Michael D Clayman, Jeff L Cleland, Paula Cobb, Ron Cooper, Mark G Currie, John Diekman, Eric L Dobmeier, Doug Doerfler, Elizabeth Lr Donley, Deborah Dunsire, Matthew During, Jens W Eckstein, Eric Elenko, Neil A Exter, Jonathan J Fleming, Gregory J Flesher, Jean-Francois Formela, Robert Forrester, Cedric Francois, Heather Franklin, Mason W Freeman, Howard Furst, Leonard Patrick Gage, Nicholas Galakatos, Brian M Gallagher, James A Geraghty, Simba Gill, David V Goeddel, Mark A Goldsmith, Maxine Gowen, Vikas Goyal, Tom Graney, David Grayzel, Barry Greene, Paul Grint, J C Gutierrez-Ramos, Bill Haney, Tuan Ha-Ngoc, Tim Harris, Faheem Hasnain, Yujiro Steve Hata, Peter Hecht, Leslie Henshaw, Rich Heyman, Herve Hoppenot, H Robert Horvitz, Thomas E Hughes, Wende S Hutton, Stephen T Isaacs, Annalisa Jenkins, Jeff Jonker, Jeff Kaplan, Perry Karsen, Jeb Keiper, Jean Kim, Jeff Kindler, Rachel King, Vanessa King, Nina Kjellson, Scott Koenig, Gerhard Koenig, Peter Kolchinsky, Paul Laikind, Robert Bob Langer, John J Lee, Jonathan S Leff, Bruce A Leicher, Nick Leschly, Andrew Levin, Mark Levin, Arnold J Levine, Alan Levy, David R Liu, Harvey F Lodish, Uri Lopatin, Ted W Love, Guy Macdonald, Gail J Maderis, Ankit Mahadevia, Nagesh K Mahanthappa, Joel F Martin, Alex Martin, W Eddie Martucci, James G McArthur, Corey M McCann, Sean A McCarthy, C Geoffrey McDonough, John Mendlein, Larry Miller, Diego Miralles, Kenneth I Moch, Bob More, Andrew G Myers, Michael A Narachi, Amir Nashat, Wendy Nelson, William J Newell, Bernat Olle, John E Osborn, Julia C Owens, Atul Pande, Stelios Papadopoulos, H Stewart Parker, Kush M Parmar, Matthew R Patterson, Steve M Paul, Rob Perez, Matthew Perry, Cary G Pfeffer, Mike Powell, Mark Pruzanski, Dennis J Purcell, Amit Rakhit, Kartik Ramamoorthi, William Rastetter, Adrian Ad Rawcliffe, Laurence E Reid, Ron C Renaud, Jason P Rhodes, William J Rieflin, Chad Robins, Scott M Rocklage, Michael Rosenblatt, Jonathan G Rosin, William J Rutter, Saurabh Saha, Camille Samuels, Vicki L Sato, George Scangos, John A Scarlett, David Schenkein, Stuart L Schreiber, Andrew Schwab, Paul Sekhri, Rajeev Shah, Thomas Shenk, Clay B Siegall, Nick J Simon, Nancy Simonian, Jeff Stein, Michael Su, Mary T Szela, Marco Taglietti, Nina Tandon, Henri Termeer, Nancy A Thornberry, Martin Tolar, Richard Ulevitch, Akshay K Vaishnaw, Anne VanLent, Martin Varsavsky, George P Vlasuk, Michel Vounatsos, Samuel G Waksal, Neil Warma, Ryan J Watts, Yaron Werber, Christoph Westphal, Wendell Wierenga, Doug E Williams, Lewis Rusty Williams, Kleanthis G Xanthopoulos, Daphne Zohar, Sandford Sandy Zweifach
No abstract text is available yet for this article.
March 7, 2017: Nature Biotechnology
P Barrett Honeycutt, Edward W Jernigan, Wayne A Rummings, Peter J Stern, Reid W Draeger
PURPOSE: To investigate the anatomy of the volar surface of the proximal phalanx of the hand, specifically the longitudinal groove running along the volar phalangeal shaft. METHODS: We measured skeletonized proximal phalanges from 10 embalmed human cadaver hands at 5 equidistant points along the shaft. The difference between the maximum dorsal-palmar thickness of the shaft and thickness measured from the center of the volar groove to the most dorsal aspect of the phalanx indicated the depth of the groove at each point...
March 2017: Journal of Hand Surgery
Matthew F Buas, Haiwei Gu, Danijel Djukovic, Jiangjiang Zhu, Lynn Onstad, Brian J Reid, Daniel Raftery, Thomas L Vaughan
INTRODUCTION/OBJECTIVES: Incidence of esophageal adenocarcinoma (EA), an often fatal cancer, has increased sharply over recent decades. Several important risk factors (reflux, obesity, smoking) have been identified for EA and its precursor, Barrett's esophagus (BE), but a key challenge remains identifying individuals at highest risk, since most with reflux do not develop BE, and most with BE do not progress to cancer. Metabolomics represents an emerging approach for identifying novel biomarkers associated with cancer development...
March 2017: Metabolomics: Official Journal of the Metabolomic Society
M Fidanza, A E Seif, A DeMicco, N Rolf, S Jo, B Yin, Y Li, D M Barrett, J Duque-Afonso, M L Cleary, C H Bassing, S A Grupp, G S D Reid
No abstract text is available yet for this article.
October 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Brian J Reid
The article by Banerjee and colleagues published in this issue of the journal involving a randomized control prevention trial of ursodeoxycholic acid (UDCA) in Barrett esophagus reported a null outcome despite being well designed and executed. Possible reasons for this null outcome are discussed focusing on use of surrogate endpoints in the trial. The trial is especially topical because it comes at a time when there are calls for a Pre-Cancer Genome Atlas (PCGA) for "understanding the earliest molecular and cellular events associated with cancer initiation…" This commentary discusses current concepts in prevention research including branched evolution that leads to therapeutic resistance...
July 2016: Cancer Prevention Research
Michael F Vaezi, Joel V Brill, Michael R Mills, Brett B Bernstein, Reid M Ness, William O Richards, Lili Brillstein, Rebecca Leibowitz, Ken Strople, Elizabeth A Montgomery, Kavita Patel
No abstract text is available yet for this article.
April 2016: Gastroenterology
Monica J Pedroni, Rama Subba Rao Vidadala, Ryan Choi, Katelyn R Keyloun, Molly C Reid, Ryan C Murphy, Lynn K Barrett, Wesley C Van Voorhis, Dustin J Maly, Kayode K Ojo, Audrey O T Lau
Babesiosis is a global zoonotic disease acquired by the bite of a Babesia-infected Ixodes tick or through blood transfusion with clinical relevance affecting humans and animals. In this study, we evaluated a series of small molecule compounds that have previously been shown to target specific apicomplexan enzymes in Plasmodium, Toxoplasma and Cryptosporidium. The compounds, bumped kinase inhibitors (BKIs), have strong therapeutic potential targeting apicomplexa-specific calcium dependent protein kinases (CDPKs)...
January 15, 2016: Veterinary Parasitology
Jacob Raber, Antiño R Allen, Sourabh Sharma, Barrett Allen, Susanna Rosi, Reid H J Olsen, Matthew J Davis, Massarra Eiwaz, John R Fike, Gregory A Nelson
The space radiation environment contains protons and (56)Fe, which could pose a significant hazard to space flight crews during and after missions. The space environment involves complex radiation exposures, thus, the effects of a dose of protons might be modulated by a dose of heavy-ion radiation. The brain, and particularly the hippocampus, may be susceptible to space radiation-induced changes. In this study, we first determined the dose-response effect of proton radiation (150 MeV) on hippocampus-dependent cognition 1 and 3 months after exposure...
January 2016: Radiation Research
M X Khor, A Bown, A Barrett, C E Counsell, M J MacLeod, J M Reid
Intravenous thrombolysis increases disability-free survival after acute ischaemic stroke in a time-dependent fashion. We aimed to determine whether pre-hospital notification, introduction of a CT scanner near to assessment site and introduction of out-of-hours thrombolysis services affect thrombolysis timing. Methods Timings related to thrombolysis were collected between May 2012 and June 2014 at a single hospital site; these included time to stroke physician assessment, time to cranial CT imaging and door to needle time...
2015: Journal of the Royal College of Physicians of Edinburgh
Katarina Lagergren, Weronica E Ek, David Levine, Wong-Ho Chow, Leslie Bernstein, Alan G Casson, Harvey A Risch, Nicholas J Shaheen, Nigel C Bird, Brian J Reid, Douglas A Corley, Laura J Hardie, Anna H Wu, Rebecca C Fitzgerald, Paul Pharoah, Carlos Caldas, Yvonne Romero, Thomas L Vaughan, Stuart MacGregor, David Whiteman, Lars Westberg, Olof Nyren, Jesper Lagergren
BACKGROUND: The strong male predominance in oesophageal adenocarcinoma (OAC) and Barrett's oesophagus (BO) continues to puzzle. Hormonal influence, e.g. oestrogen or oxytocin, might contribute. METHODS: This genetic-epidemiological study pooled 14 studies from three continents, Australia, Europe, and North America. Polymorphisms in 3 key genes coding for the oestrogen pathway (receptor alpha (ESR1), receptor beta (ESR2), and aromatase (CYP19A1)), and 3 key genes of the oxytocin pathway (the oxytocin receptor (OXTR), oxytocin protein (OXT), and cyclic ADP ribose hydrolase glycoprotein (CD38)), were analysed using a gene-based approach, versatile gene-based test association study (VEGAS)...
2015: PloS One
Sheetal Hardikar, Xiaoling Song, Rosa Ana Risques, Thomas J Montine, Catherine Duggan, Patricia L Blount, Brian J Reid, Garnet L Anderson, Mario Kratz, Emily White, Thomas L Vaughan
BACKGROUND: Telomere shortening is associated with increasing age, male gender and lifestyle factors such as obesity and smoking. Inflammation has also been implicated in cellular senescence and may promote telomere shortening in chronic conditions such as obesity and diabetes. However, little is known about the relationship between markers of obesity and inflammation, and leukocyte telomere length (LTL). METHODS: LTL was measured using quantitative polymerase chain reaction in peripheral leukocytes from 295 individuals diagnosed with Barrett's esophagus (BE) between 1995 and 2009...
2015: BMC Obesity
James Y Dai, Jean de Dieu Tapsoba, Matthew F Buas, Lynn E Onstad, David M Levine, Harvey A Risch, Wong-Ho Chow, Leslie Bernstein, Weimin Ye, Jesper Lagergren, Nigel C Bird, Douglas A Corley, Nicholas J Shaheen, Anna H Wu, Brian J Reid, Laura J Hardie, David C Whiteman, Thomas L Vaughan
BACKGROUND: Important risk factors for esophageal adenocarcinoma and its precursor, Barrett's esophagus, include gastroesophageal reflux disease, obesity, and cigarette smoking. Recently, genome-wide association studies have identified seven germline single-nucleotide polymorphisms (SNP) that are associated with risk of Barrett's esophagus and esophageal adenocarcinoma. Whether these genetic susceptibility loci modify previously identified exposure-disease associations is unclear. METHODS: We analyzed exposure and genotype data from the BEACON Consortium discovery phase GWAS, which included 1,516 esophageal adenocarcinoma case patients, 2,416 Barrett's esophagus case patients, and 2,187 control participants...
November 2015: Cancer Epidemiology, Biomarkers & Prevention
Amitabh Srivastava, Kevin L Golden, Carissa A Sanchez, Karen Liu, Pui Yee Fong, Xiaohong Li, David S Cowan, Peter S Rabinovitch, Brian J Reid, Patricia L Blount, Robert D Odze
PURPOSE: Goblet cells may represent a potentially successful adaptive response to acid and bile by producing a thick mucous barrier that protects against cancer development in Barrett's esophagus (BE). The aim of this study was to determine the relationship between goblet cells (GC) and risk of progression to adenocarcinoma, and DNA content flow cytometric abnormalities, in BE patients. EXPERIMENTAL DESIGN: Baseline mucosal biopsies (N=2988) from 213 patients, 32 of whom developed cancer during the follow up period, enrolled in a prospective dynamic cohort of BE patients were scored in a blinded fashion, for the total number (#) of GC, mean # of GC/crypt (GC density), # of crypts with ≥ 1 GC, and the proportion of crypts with ≥1 GC, in both dysplastic and non-dysplastic epithelium separately...
2015: PloS One
Brian J Reid, Thomas G Paulson, Xiaohong Li
Beginning in the 1980s, an alarming rise in the incidence of esophageal adenocarcinoma (EA) led to screening of patients with reflux to detect Barrett's esophagus (BE) and surveillance of BE to detect early EA. This strategy, based on linear progression disease models, resulted in selective detection of BE that does not progress to EA over a lifetime (overdiagnosis) and missed BE that rapidly progresses to EA (underdiagnosis). Here we review the historical thought processes that resulted in this undesired outcome and the transformation in our understanding of genetic and evolutionary principles governing neoplastic progression that has come from application of modern genomic technologies to cancers and their precursors...
October 2015: Gastroenterology
Xiaohong Li, Thomas G Paulson, Patricia C Galipeau, Carissa A Sanchez, Karen Liu, Mary K Kuhner, Carlo C Maley, Steven G Self, Thomas L Vaughan, Brian J Reid, Patricia L Blount
Cancers detected at a late stage are often refractory to treatments and ultimately lethal. Early detection can significantly increase survival probability, but attempts to reduce mortality by early detection have frequently increased overdiagnosis of indolent conditions that do not progress over a lifetime. Study designs that incorporate biomarker trajectories in time and space are needed to distinguish patients who progress to an early cancer from those who follow an indolent course. Esophageal adenocarcinoma is characterized by evolution of punctuated and catastrophic somatic chromosomal alterations and high levels of overall mutations but few recurrently mutated genes aside from TP53...
September 2015: Cancer Prevention Research
Mattie A McMaster, Amelia S Munsterman, Wendi H Weimar, Elizabeth J Barrett, R Reid Hanson
OBJECTIVE: To compare the load to ultimate failure, load to a 2 mm gap, mode of failure, and gap at failure (mm) of the Teno Fix(®) (TF) to the 3-loop pulley (3LP) for repair of equine tendon lacerations. The use of 4TF devices versus 5TF devices on load to ultimate failure and load to a 2 mm gap was also compared. STUDY DESIGN: Ex vivo biomechanical study; unbalanced incomplete block (horse) design. SAMPLES: Cadaveric equine forelimb superficial digital flexor tendon (n = 20 paired tendons)...
October 2015: Veterinary Surgery: VS
Alevtina Gall, Jutta Fero, Connor McCoy, Brian C Claywell, Carissa A Sanchez, Patricia L Blount, Xiaohong Li, Thomas L Vaughan, Frederick A Matsen, Brian J Reid, Nina R Salama
BACKGROUND: The incidence of esophageal adenocarcinoma (EAC) has increased nearly five-fold over the last four decades in the United States. Barrett's esophagus, the replacement of the normal squamous epithelial lining with a mucus-secreting columnar epithelium, is the only known precursor to EAC. Like other parts of the gastrointestinal (GI) tract, the esophagus hosts a variety of bacteria and comparisons among published studies suggest bacterial communities in the stomach and esophagus differ...
2015: PloS One
Matthew F Buas, Lynn Onstad, David M Levine, Harvey A Risch, Wong-Ho Chow, Geoffrey Liu, Rebecca C Fitzgerald, Leslie Bernstein, Weimin Ye, Nigel C Bird, Yvonne Romero, Alan G Casson, Douglas A Corley, Nicholas J Shaheen, Anna H Wu, Marilie D Gammon, Brian J Reid, Laura J Hardie, Ulrike Peters, David C Whiteman, Thomas L Vaughan
Incidence of esophageal adenocarcinoma (EA) has increased substantially in recent decades. Multiple risk factors have been identified for EA and its precursor, Barrett's esophagus (BE), such as reflux, European ancestry, male sex, obesity, and tobacco smoking, and several germline genetic variants were recently associated with disease risk. Using data from the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) genome-wide association study (GWAS) of 2,515 EA cases, 3,295 BE cases, and 3,207 controls, we examined single nucleotide polymorphisms (SNPs) that potentially affect the biogenesis or biological activity of microRNAs (miRNAs), small non-coding RNAs implicated in post-transcriptional gene regulation, and deregulated in many cancers, including EA...
2015: PloS One
Shuzheng Liu, James Y Dai, Lena Yao, Xiaohong Li, Brian Reid, Steve Self, Jie Ma, Yuxi Chang, Shixian Feng, Jean de Dieu Tapsoba, Xin Sun, Xibin Sun
No abstract text is available yet for this article.
2015: PloS One
Sisi Li, Ligia A Papale, Douglas B Kintner, Grzegorz Sabat, Gregory A Barrett-Wilt, Pelin Cengiz, Reid S Alisch
5-Hydroxymethylcytosine (5-hmC) is a novel environmentally sensitive DNA modification that is highly enriched in post-mitotic neurons and is associated with active transcription of neuronal genes. Recently, 5-hmC was functionally linked to learning and cognition and these studies revealed an accumulation of 5-hmC in the prefrontal cortex of mice undergoing fear extinction. These studies led us to hypothesize a role for 5-hmC in response to stress. To test this hypothesis, we combined immunohistochemistry, tandem mass spectrometry, and tet-assisted sodium bisulfite sequencing (TAB-seq) analyses on tissue and DNA from the hippocampus of 7-week old male mice exposed to a single 30-min restraint stress...
June 1, 2015: Behavioural Brain Research
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