Ling Xue, Guangda Ma, Nick Holford, Qiong Qin, Yinglong Ding, Jacqueline A Hannam, Xiaoliang Ding, Hongyou Fan, Zhenchun Ji, Biwen Yang, Han Shen, Zhenya Shen, Liyan Miao
The quality of warfarin treatment may be improved if management is guided by the use of models based upon pharmacokinetic-pharmacodynamic theory. A prospective, two-armed, single-blind, randomized controlled trial compared management aided by a web-based dose calculator (NextDose) with standard clinical care. Participants were 240 adults receiving warfarin therapy following cardiac surgery, followed up until the first outpatient appointment at least 3 months after warfarin initiation. We compared the percentage of time spent in the international normalized ratio acceptable range (%TIR) during the first 28 days following warfarin initiation, and %TIR and count of bleeding events over the entire follow-up period...
March 4, 2024: Clinical Pharmacology and Therapeutics