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https://www.readbyqxmd.com/read/28077006/longitudinal-assessment-of-health-related-quality-of-life-following-adolescent-sports-related-concussion
#1
Kelly Russell, Erin Selci, Stephanie Chu, Samuel Fineblit, Lesley Ritchie, Michael Ellis
OBJECTIVE: To examine initial and longitudinal health-related quality of life (HRQOL) in adolescent sports-related concussion (SRC) patients. STUDY: A prospective observational case-series study was conducted among adolescent SRC patients who were evaluated at a multi-disciplinary pediatric concussion program. Health-related quality of life was measured using the child self-report Pediatric Quality of Life Inventory (PedsQL) generic score scale (age 13-18 version) and the PedsQL Cognitive Functioning scale...
January 11, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28067742/what-definition-is-used-to-describe-second-impact-syndrome-in-sports-a-systematic-and-critical-review
#2
Steven D Stovitz, Jonathan D Weseman, Matthew C Hooks, Robert J Schmidt, Jonathan B Koffel, Jon S Patricios
Concern about what has been termed, "second impact syndrome" (SIS) is a major factor determining return-to-play decisions after concussion. However, definitions of SIS vary. We used Scopus to conduct a systematic review and categorize the definitions used to describe SIS. Of the 91 sources identified, 79 (87%) clearly specified that SIS involved either cerebral edema or death after a concussion when a prior concussion had not resolved. Twelve articles (13%) could be interpreted as merely the events of two consecutive concussions...
January 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28042930/three-versus-seven-days-to-return-to-work-after-mild-traumatic-brain-injury-a-randomised-parallel-group-trial-with-neuropsychological-assessment
#3
Aline M Studerus-Germann, Doortje C Engel, Martin N Stienen, Dieter von Ow, Gerhard Hildebrandt, Oliver P Gautschi
Although most patients with a mild traumatic brain injury (mTBI) recover within days to weeks, some experience persistent physical, cognitive and emotional symptoms, often described as postconcussion syndrome (PCS). The optimal recovery time including return-to-work (RTW) after mTBI is unclear. In this single-centre parallel-group trial, patients assigned three days (3D-group) or seven days (7D-group) sick leave were compared with a comprehensive neuropsychological test battery including the Post Concussion Symptom Scale (PCSS) within one week, after three and twelve months post-injury...
January 2, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28007313/neuropsychological-alterations-and-neuroradiological-findings-in-patients-with-post-traumatic-concussion-results-of-a-pilot-study
#4
A Rădoi, M A Poca, V Cañas, J M Cevallos, L Membrado, M C Saavedra, M Vidal, F Martínez-Ricarte, J Sahuquillo
INTRODUCTION: Mild traumatic brain injury (mTBI) has traditionally been considered to cause no significant brain damage since symptoms spontaneously remit after a few days. However, this idea is facing increasing scrutiny. The purpose of this study is to demonstrate the presence of early cognitive alterations in a series of patients with mTBI and to link these findings to different markers of brain damage. METHODS: We conducted a prospective study of a consecutive series of patients with mTBI who were evaluated over a 12-month period...
December 19, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28006970/phase-ii-clinical-trial-of-atorvastatin-in-mild-traumatic-brain-injury
#5
Claudia S Robertson, James J McCarthy, Emmy R Miller, Harvey Levin, Stephen R McCauley, Paul R Swank
Statins constitute a class of medications commonly used in the treatment of elevated cholesterol. However, in experimental studies statins also have other non-cholesterol mediated mechanisms of action, which may have neuroprotective effects. The purpose of this study was to determine if administration of atorvastatin for 7 days after injury would improve neurological recovery in patients with mild traumatic brain injury (mTBI). The hypothesis was that atorvastatin administration would reduce post-concussion symptoms and also that atorvastatin administration for one week post-injury would be safe...
December 22, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27994570/historical-review-of-the-fluid-percussion-tbi-model
#6
REVIEW
Bruce G Lyeth
Traumatic brain injury (TBI) is a major health concern worldwide. Laboratory studies utilizing animal models of TBI are essential for addressing pathological mechanisms of brain injury and development of innovative treatments. Over the past 75 years, pioneering head injury researchers have devised and tested a number of fluid percussive methods to reproduce the concussive clinical syndrome in animals. The fluid-percussion brain injury technique has evolved from early investigations that applied a generalized loading of the brain to more recent computer-controlled systems...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27979411/high-school-football-and-late-life-risk-of-neurodegenerative-syndromes-1956-1970
#7
Pieter H H Janssen, Jay Mandrekar, Michelle M Mielke, J Eric Ahlskog, Bradley F Boeve, Keith Josephs, Rodolfo Savica
OBJECTIVE: To assess whether athletes who played American varsity high school football between 1956 and 1970 have an increased risk of neurodegenerative diseases later in life. PATIENTS AND METHODS: We identified all male varsity football players between 1956 and 1970 in the public high schools of Rochester, Minnesota, and non-football-playing male varsity swimmers, wrestlers, and basketball players. Using the medical records linkage system of the Rochester Epidemiology Project, we ascertained the incidence of late-life neurodegenerative diseases: dementia, parkinsonism, and amyotrophic lateral sclerosis...
January 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27916406/cortical-excitability-after-pediatric-mild-traumatic-brain-injury
#8
Trevor A Seeger, Adam Kirton, Michael J Esser, Clare Gallagher, Jeff Dunn, Ephrem Zewdie, Omar Damji, Patrick Ciechanski, Karen M Barlow
INTRODUCTION: Mild traumatic brain injury (mTBI) outcomes are variable, and 10-15% may suffer from prolonged symptoms beyond 3 months that impair the child's return to normal activities. Neurophysiological mechanisms of mTBI are incompletely understood, particularly in children, but alterations in cortical excitability have been proposed to underlie post-concussion syndrome. Improved understanding is required to advance interventions and improve outcomes. OBJECTIVE/HYPOTHESIS: To determine if cortical excitability is altered in children with mTBI, and its association with clinical symptoms...
November 19, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27858189/ambulatory-or-inpatient-management-of-mild-tbi-in-children-a-post-concussion-analysis
#9
Danielle S Wendling-Keim, Adriana König, Hans-Georg Dietz, Markus Lehner
BACKGROUND: Diagnosis and treatment of children with mild traumatic brain injury (mTBI) remain a challenge since initial signs and symptoms do not always indicate the severity of the trauma. Therefore, guidelines regarding the decision upon imaging methods and ambulatory or hospitalized treatment are needed. The goal of our study was to investigate if the standard that was allied from the PECARN rules and is applied in this study can ensure that patients with clinically important brain injury are recognized and leads to outcomes with a low complication rate, a high patient satisfaction and minimal post-concussion syndrome incidence...
November 17, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27853132/traumatic-brain-injuries
#10
Kaj Blennow, David L Brody, Patrick M Kochanek, Harvey Levin, Ann McKee, Gerard M Ribbers, Kristine Yaffe, Henrik Zetterberg
Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe. Mild TBI (the least severe form) is synonymous with concussion and is typically caused by blunt non-penetrating head trauma. The trauma causes stretching and tearing of axons, which leads to diffuse axonal injury - the best-studied pathogenetic mechanism of this disorder. However, mild TBI is defined on clinical grounds and no well-validated imaging or fluid biomarkers to determine the presence of neuronal damage in patients with mild TBI is available...
November 17, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27842519/administration-of-electroconvulsive-therapy-for-depression-associated-with-deep-brain-stimulation-in-a-patient-with-post-traumatic-parkinson-s-disease-a-case-study
#11
Miles G Cunningham, Golnaz Yadollahikhales, Gordana Vitaliano, Craig van Horne
BACKGROUND: Deep brain stimulation (DBS) has been shown to be effective for parkinsonian symptoms poorly responsive to medications. DBS is typically well-tolerated, as are the maintenance battery changes. Here we describe an adverse event during a battery replacement procedure that caused rapid onset of severe depression. CASE PRESENTATION: The patient is a 58-year-old woman who was in a serious motor vehicle accident and sustained a concussion with loss of consciousness...
November 15, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27834587/the-effectiveness-of-hyperbaric-oxygen-therapy-as-a-treatment-for-postconcussion-symptoms
#12
Jeremy R Hawkins, Kayla E Gonzalez, Kristin Heumann
: Clinical Scenario: Concussions are a prevalent topic in medicine. Concussion symptoms include headaches, dizziness, nausea, neuropsychiatric symptoms, and cognitive impairments, the persistence of these referred to as postconcussion syndrome. The use of hyperbaric oxygen therapy (HBOT) has been proposed and evaluated as an additional treatment of these symptoms. Using HBOT is an innovative approach that has been considered by many, but has received both criticism and acceptance. CLINICAL QUESTION: Is hyperbaric oxygen therapy treatment an effective means of reducing symptoms for individuals suffering from postconcussion syndrome (persistence of symptoms for > 3 months)? Summary of Search: The literature was searched for studies that were relevant to the clinical question...
November 11, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27813685/physical-activity-and-intermittent-postconcussion-symptoms-after-a-period-of-symptom-limited-physical-and-cognitive-rest
#13
Quinton Sawyer, Brian Vesci, Tamara C Valovich McLeod
: Reference: Schneider KJ, Iverson GL, Emery CA, McCrory P, Herring SA, Meeuwisse WH. The effects of rest and treatment following sport-related concussion: a systematic review of the literature. Br J Sports Med. 2013;47(5):304-307. CLINICAL QUESTION: After concussion and a period of symptom-limited physical and cognitive rest, do athletes who experience intermittent symptoms return to asymptomatic condition more quickly with physical activity than with prolonged physical rest? DATA SOURCES: One investigator performed an individual search for each research question using the following databases: CINAHL, Cochrane Controlled Trials Registers, EMBASE, HealthSTAR, ProQuest, PsychInfo, PubMed, SPORTDiscus, and Web of Science...
September 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27812348/an-attempt-of-early-detection-of-poor-outcome-after-whiplash
#14
Sebastien Laporte, Danping Wang, Jennyfer Lecompte, Sophie Blancho, Baptiste Sandoz, Antoine Feydy, Pavel Lindberg, Julien Adrian, Elodie Chiarovano, Catherine de Waele, Pierre-Paul Vidal
The main concern with whiplash is that a large proportion of whiplash patients experience disabling symptoms or whiplash-associated disorders (WAD) for months if not years following the accident. Therefore, identifying early prognostic factors of WAD development is important as WAD have widespread clinical and economic consequences. In order to tackle that question, our study was specifically aimed at combining several methods of investigation in the same WAD patients at the acute stage and 6 months later...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27792852/cognitive-rest-and-graduated-return-to-usual-activities-versus-usual-care-for-mild-traumatic-brain-injury-a-randomized-controlled-trial-of-emergency-department-discharge-instructions
#15
Catherine E Varner, Shelley McLeod, Negine Nahiddi, Rosamond E Lougheed, Taylor E Dear, Bjug Borgundvaag
OBJECTIVES: It is estimated that 15%-25% of patients with a mild traumatic brain injury (MTBI) diagnosed in the emergency department (ED) will develop postconcussive syndrome. The objective of this study was to determine if patients randomized to graduated return to usual activity discharge instructions had a decrease in their Post-Concussion Symptom Score (PCSS) 2 weeks after MTBI compared to patients who received usual care MTBI discharge instructions. METHODS: This was a pragmatic, randomized trial of adult (18-64 years) patients of an academic ED (annual census 60,000) diagnosed with MTBI occurring within 24 hours of ED visit...
January 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27784191/longitudinal-study-of-postconcussion-syndrome-not-everyone-recovers
#16
Carmen Hiploylee, Paul Dufort, Hannah Davis, Richard Wennberg, Carmela Tartaglia, David Mikulis, Lili-Naz Hazrati, Charles Tator
We examined recovery from postconcussion syndrome (PCS) in a series of 285 patients, diagnosed with concussion based on international sport concussion criteria, who received a questionnaire regarding recovery . Of 141 respondents, those with postconcussion symptoms lasting less than 3 months, a positive CT and/or MRI, litigants, and known Test of Memory Malingering (TOMM)-positive cases were excluded, leaving 110 eligible respondents. We found that only 27% of our population eventually recovered, and 67% of those who recovered did so within the first year...
October 26, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27766190/somatization-in-post-concussion-syndrome-a-retrospective-study
#17
Kenneth Perrine, James C Gibaldi
This is a retrospective study of concussion patient data conducted to analyze the prevalence of somatization in patients presenting with post-concussion symptoms. Patient records from June 2010 to December 2015 were examined for concussion history, psychosocial history, neuropsychological test results, validity scores, and a symptom severity scale. Records meeting inclusion criteria from 33 males and 27 females were located. The sample had an age range of 11-78 years with a mean age of 33.40 (SD +/- 7.5 years)...
August 19, 2016: Curēus
https://www.readbyqxmd.com/read/27765734/current-public-knowledge-pertaining-to-traumatic-brain-injury-influence-of-demographic-factors-social-trends-and-sport-concussion-experience-on-the-understanding-of-traumatic-brain-injury-sequelae
#18
Zachary C Merz, Ryan Van Patten, John Lace
OBJECTIVE: The current study aimed to assess current broad traumatic brain injury (TBI)-related knowledge in the general public, as well as understanding regarding specific TBI-related conditions including post-concussive syndrome (PCS) and chronic traumatic encephalopathy (CTE). METHODS: Data were collected from 307 domestic and 73 international individuals via online researcher-developed survey instrumentation utilizing the Amazon Mechanical Turk marketplace, a recently developed website that allows for a streamlined process of survey-based participant recruitment and data collection...
October 20, 2016: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/27758158/concussion-like-symptom-reporting-in-non-concussed-adolescent-athletes
#19
Breton M Asken, Aliyah R Snyder, M Seth Smith, Jason L Zaremski, Russell M Bauer
OBJECTIVE: The primary goals of this study were (1) to report rates of concussion-like symptoms in healthy adolescent student athletes assessed using the Sport Concussion Assessment Tool, 3rd edition (SCAT3) at baseline, (2) to examine rates of psychiatric diagnoses in this population, and (3) to evaluate effects of baseline symptoms on SCAT3 cognitive and balance performance. METHODS: 349 adolescent student athletes (245 male) were administered the SCAT3 during pre-participation physical examinations...
October 19, 2016: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/27750113/laboratory-impulsivity-and-depression-in-blast-exposed-military-personnel-with-post-concussion-syndrome
#20
James M Bjork, Thomas K Burroughs, Laura M Franke, Treven C Pickett, Sade E Johns, F Gerard Moeller, William C Walker
In military populations, traumatic brain injury (TBI) also holds potential to increase impulsivity and impair mood regulation due to blast injury effects on ventral frontal cortex - to put military personnel at risk for suicide or substance abuse. We assessed a linkage between depression and impaired behavioral inhibition in 117 blast-exposed service members (SM) and veterans with post-concussion syndrome (PCS), where PCS was defined using a Rivermead Postconcussive Symptom Questionnaire (RPQ) modified to clarify whether each symptom worsened compared to pre-blast...
December 30, 2016: Psychiatry Research
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