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https://www.readbyqxmd.com/read/29036831/dementia-pugilistica-revisited
#1
Rudy J Castellani, George Perry
 Extensive exposure of boxers to neurotrauma in the early 20th century led to the so-called punch drunk syndrome, which was formally recognized in the medical literature in 1928. "Punch drunk" terminology was replaced by the less derisive 'dementia pugilistica' in 1937. In the early case material, the diagnosis of dementia pugilistica required neurological deficits, including slurring dysarthria, ataxia, pyramidal signs, extrapyramidal signs, memory impairment, and personality changes, although the specific clinical substrate has assumed lesser importance in recent years with a shift in focus on molecular pathogenesis...
October 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28980825/does-the-fear-avoidance-model-explain-persistent-symptoms-after-traumatic-brain-injury
#2
Melloney L M Wijenberg, Sven Z Stapert, Jeanine A Verbunt, Jennie L Ponsford, Caroline M Van Heugten
BACKGROUND: A minority of patients with mild traumatic brain injury (mTBI) experience a persistent symptom complex also known as post-concussion syndrome. Explanations for this syndrome are still lacking. OBJECTIVE: To investigate if the fear avoidance model, including catastrophizing thoughts and fear avoidance behaviour, poses a possible biopsychosocial explanation for lingering symptoms and delay in recovery after traumatic brain injury (TBI) with special focus on mTBI...
October 5, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28975240/research-gaps-and-controversies-in-chronic-traumatic-encephalopathy-a-review
#3
REVIEW
Breton M Asken, Molly J Sullan, Steven T DeKosky, Michael S Jaffee, Russell M Bauer
Importance: Scientific and lay interest in negative outcomes associated with exposure to repetitive brain trauma (RBT) continues to strengthen. Concerns about the association between RBT and dementia began more than a century ago, but have resurfaced in the last decade with the more recently described chronic traumatic encephalopathy (CTE). Chronic traumatic encephalopathy is a tauopathy associated with RBT that has become inextricably linked to conversations about sport-related concussion and mild traumatic brain injury...
October 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28969486/prognostic-value-of-s-100%C3%A3-protein-for-prediction-of-post-concussion-symptoms-following-a-mild-traumatic-brain-injury-systematic-review-and-meta-analysis
#4
Eric Mercier, Pier-Alexandre Tardif, Peter Cameron, Brice Lionel Batomen Kuimi, Marcel Émond, Lynne Moore, Biswadev Mitra, Jérôme Frenette, Elaine de Guise, Marie-Christine Ouellet, Martine Bordeleau, Natalie Le Sage
This systematic review and meta-analysis aimed to determine the prognostic value of S-100β protein to identify patients with post-concussion symptoms following a mild traumatic brain injury (mTBI). A search strategy was submitted to seven databases from their inception to October 2016. Individual patient data were requested. Cohort studies evaluating the association between S-100β protein level and post-concussion symptoms assessed at least seven days after the mTBI were considered. Outcomes were dichotomised as persistent (>= 3 months) or early (>= 7 days < 3 months)...
October 2, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28963310/characteristics-of-patients-included-and-enrolled-in-studies-on-the-prognostic-value-of-serum-biomarkers-for-prediction-of-postconcussion-symptoms-following-a-mild-traumatic-brain-injury-a-systematic-review
#5
Eric Mercier, Pier-Alexandre Tardif, Marcel Emond, Marie-Christine Ouellet, Élaine de Guise, Biswadev Mitra, Peter Cameron, Natalie Le Sage
OBJECTIVE: Mild traumatic brain injury (mTBI) has been insufficiently researched, and its definition remains elusive. Investigators are confronted by heterogeneity in patients, mechanism of injury and outcomes. Findings are thus often limited in generalisability and clinical application. Serum protein biomarkers are increasingly assessed to enhance prognostication of outcomes, but their translation into clinical practice has yet to be achieved. A systematic review was performed to describe the adult populations included and enrolled in studies that evaluated the prognostic value of protein biomarkers to predict postconcussion symptoms following an mTBI...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28952858/sub-symptomatic-aerobic-exercise-for-patients-with-post-concussion-syndrome-a-critically-appraised-topic
#6
Katrina G Ritter, Matthew J Hussey, Tamara C Valovich McLeod
Clinical Scenario: Patients who experience prolonged concussion symptoms can be diagnosed with Post-Concussion Syndrome (PCS) when those symptoms persist past 4 weeks. Aerobic exercise protocols have been shown to be effective in improving physical and mental aspects of health. Emerging research suggests that aerobic exercise maybe useful as a treatment for PCS, where exercise allows patients to feel less isolated and more active during the recovery process. CLINICAL QUESTION: Is aerobic exercise more beneficial in reducing symptoms than current standard care in patients with prolonged symptoms or PCS lasting longer than 4 weeks? Summary of Key Findings: After a thorough literature search, 4 studies were selected relevant to the clinical question...
September 27, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28939003/factors-associated-with-post-concussion-syndrome-in-high-school-student-athletes
#7
Zachary Y Kerr, Scott L Zuckerman, Erin W Wasserman, Christina B Vander Vegt, Aaron Yengo-Kahn, Thomas A Buckley, Gary S Solomon, Allen K Sills, Thomas P Dompier
OBJECTIVES: To identify factors associated with post-concussion syndrome (PCS) among a national sample of high school student-athletes from the 2011/12-2013/14 academic years. DESIGN: Ambispective cohort study from sports injury surveillance data. METHODS: Sport-related concussion data originated from the National Athletic Treatment, Injury and Outcomes Network (NATION) surveillance program, consisting of 27 sports from a convenience sample of 196 high schools across 26 states...
September 14, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28895491/preliminary-validation-of-the-whodas-2-0-for-mild-traumatic-brain-injury
#8
Deborah Snell, Grant L Iverson, William Panenka, Noah D Silverberg
The purpose of this study is to examine the reliability, factor structure, and validity of the World Health Organization Disability Assessment Schedule (WHODAS 2.0 12-item version) in a sample of patients who were slow to recover from a mild traumatic brain injury (MTBI). Participants were 79 adults with MTBI recruited from one of four specialty outpatient clinics in Vancouver, Canada. The WHODAS 2.0 12-item version is a disease-non-specific measure of disability representing six International Classification of Disability, Functioning, and Health activity and participation domains including cognition, mobility, self-care, interpersonal functioning, life activities, and participation...
September 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28878731/head-eye-vestibular-motion-therapy-affects-the-mental-and-physical-health-of-severe-chronic-postconcussion-patients
#9
Frederick Robert Carrick, Joseph F Clark, Guido Pagnacco, Matthew M Antonucci, Ahmed Hankir, Rashid Zaman, Elena Oggero
CONTEXT: Approximately 1.8-3.6 million annual traumatic brain injuries occur in the United States. An evidence-based treatment for concussions that is reliable and effective has not been available. OBJECTIVE: The objective of this study is to test whether head-eye vestibular motion (HEVM) therapy is associated with decreased symptoms and increased function in postconcussive syndrome (PCS) patients that have been severely impaired for greater than 6 months after a mild traumatic brain injury...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28874926/craniosacral-therapy-and-visceral-manipulation-a-new-treatment-intervention-for-concussion-recovery
#10
Gail Wetzler, Melinda Roland, Sally Fryer-Dietz, Dee Dettmann-Ahern
Background: Military service members and veterans face health issues related to traumatic brain injury (TBI), especially during combat, use of heavy equipment, and exposures to environmental hazards and explosives. There were 400,000 TBIs reported in deployed U.S. troops in 2012. Athletes are also subject to TBI. Studies have indicated that some manual therapies could be helpful for treating patients who have post-concussive syndrome. Objective: This case series report describes the effects of CranioSacral Therapy (CST), Visceral Manipulation (VM), and Neural Manipulation (NM) modalities for treating patients who have post-concussion syndrome...
August 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/28863142/assessing-the-accuracy-of-blood-rna-profiles-to-identify-patients-with-post-concussion-syndrome-a-pilot-study-in-a-military-patient-population
#11
Jimmaline J Hardy, Scott R Mooney, Andrea N Pearson, Dawn McGuire, Daniel J Correa, Roger P Simon, Robert Meller
Mild traumatic brain injury (mTBI) is a complex, neurophysiological condition that can have detrimental outcomes. Yet, to date, no objective method of diagnosis exists. Physical damage to the blood-brain-barrier and normal waste clearance via the lymphatic system may enable the detection of biomarkers of mTBI in peripheral circulation. Here we evaluate the accuracy of whole transcriptome analysis of blood to predict the clinical diagnosis of post-concussion syndrome (PCS) in a military cohort. Sixty patients with clinically diagnosed chronic concussion and controls (no history of concussion) were recruited (retrospective study design)...
2017: PloS One
https://www.readbyqxmd.com/read/28859119/characteristics-of-the-king-devick-test-in-the-assessment-of-concussed-patients-in-the-subacute-and-later-stages-after-injury
#12
Arsenije Subotic, Windsor Kwan-Chun Ting, Michael D Cusimano
Although the King-Devick (K-D) test has been used frequently in assessing sports related concussion early after injury, its characteristics over time after injury and in patients with prolonged persistent symptoms are unknown. The purpose of this paper was to: evaluate the ability of the K-D Test to distinguish patients seen early after concussion from those with symptoms persisting more than 3 months compared to controls, assess changes in the K-D test times over time after concussion, and determine the relationship of K-D times to the Stroop Color and Word Test scores...
2017: PloS One
https://www.readbyqxmd.com/read/28855139/the-effect-of-an-acute-systemic-inflammatory-insult-on-the-chronic-effects-of-a-single-mild-traumatic-brain-injury
#13
Lyndsey E Collins-Praino, Alina Arulsamy, Viythia Katharesan, Frances Corrigan
A small but significant proportion of mild traumatic brain injury (mTBI) sufferers will report persistent symptoms, including depression, anxiety and cognitive deficits, in the months, or even years, following the initial event. This is known as post-concussion syndrome and its pathogenesis is not yet known. This study sought to investigate the role of a peripheral inflammatory insult in the development of ongoing behavioral symptoms following a mTBI. To investigate, male Sprague-Dawley rats were administered a single mTBI using the diffuse impact-acceleration model to generate ∼100G of force...
January 15, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/28817065/evaluation-and-treatment-of-mild-traumatic-brain-injury-the-role-of-neuropsychology
#14
REVIEW
Carolyn Prince, Maya E Bruhns
Awareness of mild traumatic brain injury (mTBI) and persisting post-concussive syndrome (PCS) has increased substantially in the past few decades, with a corresponding increase in research on diagnosis, management, and treatment of patients with mTBI. The purpose of this article is to provide a narrative review of the current literature on behavioral assessment and management of patients presenting with mTBI/PCS, and to detail the potential role of neuropsychologists and rehabilitation psychologists in interdisciplinary care for this population during the acute, subacute, and chronic phases of recovery...
August 17, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28816519/the-effects-of-exercise-on-a-choice-reaction-time-task-in-individuals-with-post-concussion-syndrome
#15
Stephanie A Ramautar, Alyssa A Prangley, Michael E Cinelli
PURPOSE: To assess cognitive performance differences pre- and post-exercise in individuals without concussion (non-concussed, NC) and individuals with post-concussion syndrome (PCS). METHODS: A total of 30 participants completed a choice reaction time (CRT) task in the form of an iPad application, measuring each individual's decision-making capabilities, while wearing a head-mounted eye tracker system. Participants completed four blocks of testing; the time interval between the first two blocks of trials and the last two blocks of trials was 10 minutes...
August 17, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28760573/work-productivity-loss-after-mild-traumatic-brain-injury
#16
Noah D Silverberg, William J Panenka, Grant L Iverson
OBJECTIVES: To examine the completeness of return to work (RTW) and the degree of productivity loss in individuals who do achieve a complete RTW after mild traumatic brain injury (MTBI). DESIGN: Multisite prospective cohort. SETTING: Outpatient concussion clinics. PARTICIPANTS: Patients (N=79; mean age, 41.5y; 55.7% women) who sustained an MTBI and were employed at the time of the injury. Participants were enrolled at their first clinic visit and assessed by telephone 6 to 8 months postinjury...
July 29, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28736353/sport-related-structural-brain-injury-3-cases-of-subdural-hemorrhage-in-american-high-school-football
#17
Aaron M Yengo-Kahn, Ryan M Gardner, Andrew W Kuhn, Gary S Solomon, Christopher M Bonfield, Scott L Zuckerman
BACKGROUND: The risk of sport-related concussion (SRC) has emerged as a major public health concern. In rare instances, sport-related head injuries can be even more severe, such as subdural hemorrhage, epidural hemorrhage, or malignant cerebral edema. Unlike SRCs, sport-related structural brain injury (SRSBI) is rare, may require neurosurgical intervention, and can lead to permanent neurologic deficit or death. Data characterizing SRSBI are limited, and many have recognized the need to better understand these catastrophic brain injuries...
October 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28693073/-resting-state-fmri-study-of-emotional-network-in-patients-with-postconcussion-syndrome
#18
X Zhang, R B Qian, X M Fu, B Lin, D Zhang, C S Xia, X P Wei, C S Niu, Y H Wang
Objective: To discuss functional connectivity changes in the emotional network of patients with post-concussion syndrome (PCS) and their clinical significance by resting-state functional magnetic resonance imaging (rs-fMRI). Methods: Twenty-seven patients with PCS were recruited from the Department of Neurosurgery of Anhui provincial hospital affiliated to Anhui medical university from October 2015 to April 2016, and 27 healthy subjects were recruited as the controls. The Hamilton Anxiety Scale (HAMA) and The Hamilton Depression Scale (HAMD) were used to evaluate the emotional state of two groups of subjects...
July 4, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28685977/the-post-therapeutic-effect-of-rapamycin-in-mild-traumatic-brain-injured-rats-ensuing-in-the-upregulation-of-autophagy-and-mitophagy
#19
Changxing Wang, Zhiying Hu, Yang Zou, Mingjun Xiang, Yuting Jiang, Benson O A Botchway, Xue Huo, Xiaoxue Du, Marong Fang
Mild traumatic brain injury (mTBI), common in juveniles, has been reported to be caused by sports-related concussion. Many young children may suffer from post-concussion syndrome. mTBI, in early stages of life, could play a part in neuron apoptosis and degeneration, cognitive and motor coordination impairment, as well as dementia. Our study was aimed at further investigating the post-therapeutic efficacy of rapamycin in the recuperation of mTBI while at the same time investigating the metamorphosis in both autophagy and mitophagy in mTBI...
September 2017: Cell Biology International
https://www.readbyqxmd.com/read/28680725/glioblastoma-multiforme-presenting-with-an-open-ring-pattern-of-enhancement-on-mr-imaging
#20
Merritt D Kinon, Aleka Scoco, Joaquim M Farinhas, Andrew Kobets, Karen M Weidenheim, Reza Yassari, Patrick A Lasala, Jerome Graber
BACKGROUND: Intracerebral ring enhancing lesions can be the presentation of a variety of pathologies, including neoplasia, inflammation, and autoimmune demyelination. Use of a precise diagnostic algorithm is imperative in correctly treating these lesions and minimizing potential adverse treatment effects. CASE DESCRIPTION: A 55-year-old patient presented to the hospital with complaints of a post-concussive syndrome and a non-focal neurologic exam. Imaging revealed a lesion with an open ring enhancement pattern, minimal surrounding vasogenic edema, and minimal mass effect...
2017: Surgical Neurology International
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