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https://www.readbyqxmd.com/read/28983378/comparative-evaluation-of-three-palliative-radiotherapy-schedules-in-locally-advanced-head-and-neck-cancer
#1
Abhishek Soni, Vivek Kaushal, Monica Verma, Anil Kumar Dhull, Rajeev Atri, Rakesh Dhankhar
BACKGROUND: The aim of the study was to evaluate and compare the efficacy, tolerability and toxicity of three palliative radiotherapy (RT) schedules in locally advanced head and neck carcinoma (LAHNC), i.e. Quad Shot schedule, Christie schedule and conventional palliative schedule. METHODS: The patients were randomly divided into three groups of 30 each. Group I patients were planned for 14.8 Gy in 4 fractions over 2 days, repeated three weekly for two more cycles...
February 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/28975876/twin-studies-in-brazil-projects-and-plans-twin-research-infant-twins-viewing-of-social-scenes-religiosity-and-substance-abuse-down-syndrome-among-twins-twin-case-of-chronic-periodontitis-in-the-news-the-twin-property-brothers-twins-with-cerebral-palsy-twins
#2
Nancy L Segal
Twin research in Brazil twin has expanded enormously in recent years, engaging the interests and efforts of many investigators, students and twins. Descriptions and brief summaries of this work and talks given by investigators at local conferences are presented, based on my four-city lecture tour. This is followed by summaries of twin research on infants' viewing of social scenes, religiosity and substance abuse, Down syndrome, and chronic periodontitis. This article concludes with twin-related news and information of general interest, including identical twin property designers, twins with cerebral palsy, twins affected with the Zika virus, a pair of twin writers, twins in sports, and a set of quadruplets from my childhood neighborhood in Riverdale, New York...
October 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28942329/investigation-of-quad-energy-high-rate-photon-counting-for-x-ray-computed-tomography-using-a-cadmium-telluride-detector
#3
Hiroshi Matsukiyo, Eiichi Sato, Yasuyuki Oda, Satoshi Yamaguchi, Yuichi Sato, Osahiko Hagiwara, Toshiyuki Enomoto, Manabu Watanabe, Shinya Kusachi
To obtain four kinds of tomograms at four different X-ray energy ranges simultaneously, we have constructed a quad-energy (QE) X-ray photon counter with a cadmium telluride (CdTe) detector and four sets of comparators and microcomputers (MCs). X-ray photons are detected using the CdTe detector, and the event pulses produced using amplifiers are sent to four comparators simultaneously to regulate four threshold energies of 20, 33, 50 and 65keV. Using this counter, the energy ranges are 20-33, 33-50, 50-65 and 65-100keV; the maximum energy corresponds to the tube voltage...
September 10, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28935272/genome-wide-association-study-evaluating-single-nucleotide-polymorphisms-and-outcomes-in-patients-with-advanced-stage-serous-ovarian-or-primary-peritoneal-cancer-an-nrg-oncology-gynecologic-oncology-group-study
#4
Kathleen N Moore, David Tritchler, Kenneth M Kaufman, Heather Lankes, Michael C J Quinn, Linda Van Le, Andrew Berchuck, Floor J Backes, Krishnansu S Tewari, Roger B Lee, Joshua P Kesterson, Robert M Wenham, Deborah K Armstrong, Thomas C Krivak, Michael A Bookman, Michael J Birrer
OBJECTIVE: This study evaluated single nucleotide polymorphisms (SNPs) associated with progression free (PFS) and overall survival (OS) in patients with advanced stage serous EOC. METHODS: Patients enrolled in GOG-172 and 182 who provided specimens for translational research and consent were included. Germline DNA was evaluated with the Illumina's HumanOMNI1-Quad beadchips and scanned using Illumina's iScan optical imaging system. SNPs with allele frequency>0...
November 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28886140/male-specific-association-of-the-fcgr2a-his167arg-polymorphism-with-kawasaki-disease
#5
Young-Chang Kwon, Jae-Jung Kim, Sin Weon Yun, Jeong Jin Yu, Kyung Lim Yoon, Kyung-Yil Lee, Hong-Ryang Kil, Gi Beom Kim, Myung-Ki Han, Min Seob Song, Hyoung Doo Lee, Kee-Soo Ha, Sejung Sohn, Ryota Ebata, Hiromichi Hamada, Hiroyuki Suzuki, Kaoru Ito, Yoshihiro Onouchi, Young Mi Hong, Gi Young Jang, Jong-Keuk Lee
Kawasaki disease (KD) is an acute systemic vasculitis that can potentially cause coronary artery aneurysms in some children. KD occurs approximately 1.5 times more frequently in males than in females. To identify sex-specific genetic variants that are involved in KD pathogenesis in children, we performed a sex-stratified genome-wide association study (GWAS), using the Illumina HumanOmni1-Quad BeadChip data (249 cases and 1,000 controls) and a replication study for the 34 sex-specific candidate SNPs in an independent sample set (671 cases and 3,553 controls)...
2017: PloS One
https://www.readbyqxmd.com/read/28809049/evolution-of-mnc-and-lymphocyte-collection-settings-employing-different-spectra-optia-%C3%A2-leukapheresis-systems
#6
M Punzel, A Kozlova, A Quade, A H Schmidt, R Smith
BACKGROUND AND OBJECTIVES: The Spectra Optia(®) continuous mononuclear cell (CMNC apheresis) system has emerged as the preferred device in peripheral blood stem cell collections over the original two-step Spectra Optia(®) mononuclear cell (MNC apheresis) system. Until now, no comparative data were available for non-stimulated MNC collections that are required for immunotherapy. MATERIALS AND METHODS: We compared collection parameters and product composition for Spectra Optia MNC- as well as CMNC-apheresis systems in non-stimulated MNC collections from 35 registry donors intended for donor lymphocyte infusions...
August 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28614149/ota-ao-classification-is-highly-predictive-of-acute-compartment-syndrome-after-tibia-fracture-a-cohort-of-2885-fractures
#7
Michael J Beebe, Darryl A Auston, Jonathan H Quade, Rafael Serrano-Riera, Anjan R Shah, David T Watson, Roy W Sanders, Hassan R Mir
OBJECTIVE: To determine the correlation between the OTA/AO classification of tibia fractures and the development of acute compartment syndrome (ACS). DESIGN: Retrospective review of prospectively collected database. SETTING: Single Level 1 academic trauma center. PATIENTS: All patients with a tibia fracture from 2006 to 2016 were reviewed for this study. Three thousand six hundred six fractures were initially identified...
November 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28280519/3d-kidney-segmentation-from-abdominal-images-using-spatial-appearance-models
#8
Fahmi Khalifa, Ahmed Soliman, Adel Elmaghraby, Georgy Gimel'farb, Ayman El-Baz
Kidney segmentation is an essential step in developing any noninvasive computer-assisted diagnostic system for renal function assessment. This paper introduces an automated framework for 3D kidney segmentation from dynamic computed tomography (CT) images that integrates discriminative features from the current and prior CT appearances into a random forest classification approach. To account for CT images' inhomogeneities, we employ discriminate features that are extracted from a higher-order spatial model and an adaptive shape model in addition to the first-order CT appearance...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28160364/peripheral-nerve-stimulation-of-brachial-plexus-nerve-roots-and-supra-scapular-nerve-for-chronic-refractory-neuropathic-pain-of-the-upper-limb
#9
Bénédicte Bouche, Marie Manfiotto, Philippe Rigoard, Jean Lemarie, Véronique Dix-Neuf, Michel Lanteri-Minet, Denys Fontaine
OBJECTIVES: We report the outcome of a consecutive series of 26 patients suffering from chronic medically-refractory neuropathic pain of the upper limb (including 16 patients with complex regional pain syndrome), topographically limited, treated by brachial plexus (BP) nerve roots or supra-scapular nerve (SSN) peripheral nerve stimulation (PNS). MATERIALS AND METHODS: The technique consisted in ultrasound-guided percutaneous implantation of a cylindrical lead (Pisces-Quad, Medtronic) close to the SSN or the cervical nerve roots within the BP, depending on the pain topography...
October 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28103041/substituent-effects-on-the-absorption-and-fluorescence-properties-of-anthracene
#10
Salsabil Abou-Hatab, Vincent A Spata, Spiridoula Matsika
Substitution can be used to efficiently tune the photophysical properties of chromophores. In this study, we examine the effect of substituents on the absorption and fluorescence properties of anthracene. The effects of mono-, di-, and tetrasubstitution of electron-donating and -withdrawing functional groups were explored. In addition, the influence of a donor-acceptor substituent pair and the position of substitution were investigated. Eleven functional groups were varied on positions 1, 2, and 9 of anthracene, and on position 6 of 2-methoxyanthracene and 2-carboxyanthracene...
February 1, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28005090/-guidelines-for-the-use-of-the-international-classification-of-radiographs-of-pneumoconioses-of-the-international-labour-office-ilo-substantial-changes-in-the-currrent-edition
#11
Maja Muszyńska-Graca, Beata Dąbkowska, Piotr Z Brewczyński
The International Classification of Radiographs of Pneumoconioses is the scheme worked out by the International Labour Office in Geneva (ILO), to register radiographic chest abnormalities in a well-ordered, reproducible and comparable way. It is used for diagnosing abnormalities caused by dust exposure. Guidelines for the use of the ILO International Classification of Radiographs of Pneumoconioses contain detailed information and recommendations on how to use the classification, as well as how the chest X-ray examination should be performed and recorded...
December 22, 2016: Medycyna Pracy
https://www.readbyqxmd.com/read/27869108/limonene-in-exhaled-breath-is-elevated-in-hepatic-encephalopathy
#12
M E O'Hara, R Fernández Del Río, A Holt, P Pemberton, T Shah, T Whitehouse, C A Mayhew
Breath samples were taken from 31 patients with liver disease and 30 controls in a clinical setting and proton transfer reaction quadrupole mass spectrometry (PTR-Quad-MS) used to measure the concentration of volatile organic compounds (VOCs). All patients had cirrhosis of various etiologies, with some also suffering from hepatocellular cancer (HCC) and/or hepatic encephalopathy (HE). Breath limonene was higher in patients with No-HCC than with HCC, median (lower/upper quartile) 14.2 (7.2/60.1) versus 3.6 (2...
November 21, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27577384/architecture-of-a-biomedical-informatics-research-data-management-pipeline
#13
Christian R Bauer, Nadine Umbach, Benjamin Baum, Karoline Buckow, Thomas Franke, Romanus Grütz, Linda Gusky, Sara Yasemin Nussbeck, Matthias Quade, Sabine Rey, Thorsten Rottmann, Otto Rienhoff, Ulrich Sax
In University Medical Centers, heterogeneous data are generated that cannot always be clearly attributed to patient care or biomedical research. Each data set has to adhere to distinct intrinsic and operational quality standards. However, only if high-quality data, tools to work with the data, and most importantly guidelines and rules of how to work with the data are addressed adequately, an infrastructure can be sustainable. Here, we present the IT Research Architecture of the University Medical Center Göttingen and describe our ten years' experience and lessons learned with infrastructures in networked medical research...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27491695/long-term-repeatability-and-reproducibility-of-phosphene-characteristics-in-chronically-implanted-argus-ii-retinal-prosthesis-subjects
#14
Yvonne H-L Luo, Joe Jiangjian Zhong, Monica Clemo, Lyndon da Cruz
PURPOSE: Previously published literatures of acute studies on few subjects have shown contradictory evidence on the reproducibility and characteristics of the elicited phosphenes, despite using the same stimulating parameters with epiretinal electrode arrays. In this study, we set out to investigate the long-term repeatilibity and reproducibility of phosphenes in subjects chronically implanted with the Argus II retinal prosthesis (Second Sight Medical Products, Inc., Sylmar, CA, USA)...
October 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27458058/less-with-more-hospitalization-cost-and-event-rates-with-quadripolar-versus-bipolar-crt-d-system
#15
COMPARATIVE STUDY
Raffaele Corbisiero, Pedram Kazemian, Rupinder Bharmi, Riddhi Shah, David Muller
BACKGROUND: This is a comparative effectiveness study for cardiac resynchronization therapy defibrillator (CRT-D) therapy enabled by quadripolar (QUAD) versus bipolar (BIP) left ventricular (LV) leads.  Heart failure (HF) hospitalization (HFH) rates, associated costs, and 30-day readmissions after index HFH were compared. METHODS: Patients with de novo LV leads implanted as part of a CRT-D system between January 2011 and August 2013 with ≥1-year follow-up were included...
October 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27334288/no-associations-of-a-set-of-snps-in-the-vascular-endothelial-growth-factor-vegf-and-matrix-metalloproteinase-mmp-genes-with-survival-of-colorectal-cancer-patients
#16
Lydia A Dan, Salem Werdyani, Jingxiong Xu, Konstantin Shestopaloff, Angela Hyde, Elizabeth Dicks, Ban Younghusband, Jane Green, Patrick Parfrey, Wei Xu, Sevtap Savas
In this study, we aimed to investigate the associations of genetic variations within select genes functioning in angiogenesis, lymph-angiogenesis, and metastasis pathways and the risk of outcome in colorectal cancer patients. We followed a two-stage analysis: First, 381 polymorphisms from 30 genes (eight Vascular Endothelial Growth Factor (VEGF) and 22 Matrix Metalloproteinase [MMP] genes) were investigated in the discovery cohort (n = 505). Then, 16 polymorphisms with the lowest P-value in this analysis were investigated in a separate replication cohort (n = 247)...
September 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27301908/the-use-of-cystosure-to-enable-posthysterectomy-cystoscopic-evaluation-a-case-series
#17
Mobolaji O Ajao, Mary K B Cox, Sarah L Cohen, Jon I Einarsson
Cystoscopy can be used to diagnose urologic injuries at the time of gynecologic surgery. Current cystoscopy setup involves removing the indwelling catheter placed for the procedure and assembling a multicomponent cystoscope. The objective of this study was to evaluate and report on our initial experience with CystoSure (Emmy Medical, Holliston, MA), a new Food and Drug Administration-approved device designed to facilitate perioperative diagnostic cystoscopy. The CystoSure catheter is an 18F quad-port silicone transurethral catheter with a central sealed port for the cystoscope and a side port that allows for bladder filling...
September 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27298359/rational-design-and-validation-of-a-vanilloid-sensitive-trpv2-ion-channel
#18
Fan Yang, Simon Vu, Vladimir Yarov-Yarovoy, Jie Zheng
Vanilloids activation of TRPV1 represents an excellent model system of ligand-gated ion channels. Recent studies using cryo-electron microcopy (cryo-EM), computational analysis, and functional quantification revealed the location of capsaicin-binding site and critical residues mediating ligand-binding and channel activation. Based on these new findings, here we have successfully introduced high-affinity binding of capsaicin and resiniferatoxin to the vanilloid-insensitive TRPV2 channel, using a rationally designed minimal set of four point mutations (F467S-S498F-L505T-Q525E, termed TRPV2_Quad)...
June 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26661068/salting-out-assisted-liquid-liquid-extraction-as-a-suitable-approach-for-determination-of-methoxetamine-in-large-sets-of-tissue-samples
#19
Katerina Hajkova, Bronislav Jurasek, David Sykora, Tomas Palenicek, Petra Miksatkova, Martin Kuchar
A new designer drug, a dissociative anesthetic, and a putative N-methyl-D-aspartate receptor antagonist, methoxetamine (MXE) noted by the EU Early Warning System has been already identified as a cause of several fatalities worldwide. The primary objective of this work was to develop a suitable sample preparation method allowing for isolation of MXE and its main metabolites in high yields from rat brain, liver, and lungs. For the purpose of the project, MXE and five metabolites were synthesized in-house, specifically O-desmethyl-normethoxetamine, O-desmethylmethoxetamine, dihydro-O-desmethylmethoxetamine, normethoxetamine, and dihydromethoxetamine...
February 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/26631777/quantum-chemistry-on-graphical-processing-units-3-analytical-energy-gradients-geometry-optimization-and-first-principles-molecular-dynamics
#20
Ivan S Ufimtsev, Todd J Martinez
We demonstrate that a video gaming machine containing two consumer graphical cards can outpace a state-of-the-art quad-core processor workstation by a factor of more than 180× in Hartree-Fock energy + gradient calculations. Such performance makes it possible to run large scale Hartree-Fock and Density Functional Theory calculations, which typically require hundreds of traditional processor cores, on a single workstation. Benchmark Born-Oppenheimer molecular dynamics simulations are performed on two molecular systems using the 3-21G basis set - a hydronium ion solvated by 30 waters (94 atoms, 405 basis functions) and an aspartic acid molecule solvated by 147 waters (457 atoms, 2014 basis functions)...
October 13, 2009: Journal of Chemical Theory and Computation
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