keyword
MENU ▼
Read by QxMD icon Read
search

antivenom adverse reaction

keyword
https://www.readbyqxmd.com/read/27762105/clinical-profile-and-laboratory-parameters-in-1051-victims-of-snakebite-from-a-single-centre-in-kerala-south-india
#1
J C Menon, J K Joseph, M P Jose, B L Dhananjaya, O V Oommen
INTRODUCTION: Snakebite is an occupational hazard causing considerable morbidity and mortality worldwide, particularly so in tropical countries like India. OBJECTIVE: The aim of this study is to (i) review the demographic, clinical and laboratory findings in patients (1051) admitted with venomous snakebite (ii) to correlate mortality, morbidity and duration of hospital stay with clinical signs, symptoms and laboratory parameters. METHODS: A retrospective study of 1051 patients treated for snakebite over 10 years (2000 - 2009) in Little Flower Hospital, Angamaly, Kerala...
August 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27530663/efficacy-of-intravenous-hydrocortisone-administered-2-4%C3%A2-h-prior-to-antivenom-as-prophylaxis-against-adverse-drug-reactions-to-snake-antivenom-in-sri-lanka-an-open-labelled-randomized-controlled-trial
#2
Senanayake A M Kularatne, Kosala Weerakoon, Anjana Silva, Kalana Maduwage, Chamara Walathara, Ishani Rathnayake, Senal Medagedara, Ranjith Paranagama, Suresh Mendis, P V R Kumarasiri
The prevention of adverse drug reactions to antivenom serum poses a formidable challenge in the management of snakebite. Hydrocortisone is being used concurrently with antivenom in order to prevent these adverse drug reactions without a proven benefit. However, all previous studies seemed to ignore the testing of effectiveness of hydrocortisone therapy during its pharmacological effects, which come hours later. On this principle, we aimed to test the effectiveness of intravenous hydrocortisone given 2 h or more prior to the commencement of antivenom therapy to reduce adverse drug reactions to antivenom...
September 15, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27027633/cost-effectiveness-of-antivenoms-for-snakebite-envenoming-in-16-countries-in-west-africa
#3
Muhammad Hamza, Maryam A Idris, Musa B Maiyaki, Mohammed Lamorde, Jean-Philippe Chippaux, David A Warrell, Andreas Kuznik, Abdulrazaq G Habib
BACKGROUND: Snakebite poisoning is a significant medical problem in agricultural societies in Sub Saharan Africa. Antivenom (AV) is the standard treatment, and we assessed the cost-effectiveness of making it available in 16 countries in West Africa. METHODS: We determined the cost-effectiveness of AV based on a decision-tree model from a public payer perspective. Specific AVs included in the model were Antivipmyn, FAV Afrique, EchiTab-G and EchiTab-Plus. We derived inputs from the literature which included: type of snakes causing bites (carpet viper (Echis species)/non-carpet viper), AV effectiveness against death, mortality without AV, probability of Early Adverse Reactions (EAR), likelihood of death from EAR, average age at envenomation in years, anticipated remaining life span and likelihood of amputation...
March 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26995210/prospective-consecutive-case-series-of-158-snakebite-patients-treated-at-savannakhet-provincial-hospital-lao-people-s-democratic-republic-with-high-incidence-of-anaphylactic-shock-to-horse-derived-f-ab-2-antivenom
#4
Inthanomchanh Vongphoumy, Phankham Chanthilat, Phongmany Vilayvong, Joerg Blessmann
Snakebites are a seriously neglected public health problem in Lao PDR. Community-based cross-sectional surveys in two districts of Savannakhet province in Southern Laos revealed an incidence of up to 1105 snakebites per 100,000 persons per year. In contrast the number of snakebite patients treated in district and provincial hospitals are low. In order to improve health care for snakebite victims, antivenom was introduced to Savannakhet provincial hospital in July 2013 and medical staff has been trained in management of venomous snakebites at the same time...
July 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/26309424/pattern-of-adverse-drug-reactions-in-children-attending-the-department-of-pediatrics-in-a-tertiary-care-center-a-prospective-observational-study
#5
Kishour Kumar Digra, Aakash Pandita, G S Saini, Rajni Bharti
AIM: To study the pattern of various adverse drug reactions (ADRs) occurring in children attending the Department of Pediatrics, SMGS Hospital, Jammu over 1 year. SUBJECTS AND METHODS: This was a prospective study, with study population of patients attending Department of Pediatrics over a period of 1 year. A structured format was used to enroll the participants. A pilot study was conducted to test the suitability of the format and feasibility of the study. The study was carried out to review various pattern of ADRs by using the Naranjo probability scale, and severity was assessed by using the Hartwig severity scale...
2015: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/26256124/adverse-reactions-to-snake-antivenom-and-their-prevention-and-treatment
#6
REVIEW
H Asita de Silva, Nicole M Ryan, H Janaka de Silva
Antivenom is the mainstay of treatment of snakebite envenoming. However, adverse reactions to snake antivenom that is available are common in many parts of the world where snakebite is prevalent. Both acute (anaphylactic or pyrogenic) and delayed (serum sickness type) reactions occur. Acute reactions are usually mild but severe systemic anaphylaxis may develop, often within an hour or so of exposure to antivenom. Serum sickness after antivenom has a delayed onset between 5 and 14 days after its administration...
March 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/26242786/quality-control-testing-for-tracking-endotoxin-producing-gram-negative-bacteria-during-the-preparation-of-polyvalent-snake-antivenom-immunoglobulin
#7
Norhan S Sheraba, Mohamed R Diab, Aymen S Yassin, Magdy A Amin, Hamdallah H Zedan
UNLABELLED: Snake bites represent a serious public health problem, particularly in rural areas worldwide. Antitoxic sera preparations are antibodies from immunized animals and are considered to be the only treatment option. The purification of antivenom antibodies should aim at obtaining products of consistent quality, safety, efficacy, and adherence to good manufacturing practice principles. Endotoxins are an integral component of the outer cell surface of Gram-negative bacteria. They are common contaminates of the raw materials and processing equipment used in the manufacturing of antivenoms...
July 2015: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/25705418/clinical-characteristics-of-redback-spider-bites
#8
Toru Hifumi, Satoshi Fujimi, Takuya Yamagishi, Satoru Arai, Kyoko Sawabe, Akihiko Yamamoto, Manabu Ato, Keigo Shibayama, Akihiko Ginnaga, Nobuaki Kiriu, Hiroshi Kato, Yuichi Koido, Junichi Inoue, Masanobu Kishikawa, Yuko Abe, Kenya Kawakita, Masanobu Hagiike, Yasuhiro Kuroda
BACKGROUND: Redback spiders (Latrodectus hasselti) (RBSs) are venomous spiders that have recently spread to Asia from Australia. Since the first case report in 1997 (Osaka), RBS bites have been a clinical and administrative issue in Japan; however, the clinical characteristics and effective treatment of RBS bites, particularly outside Australia remains unclear. This study aimed to elucidate the clinical characteristics of RBS bites and to clarify the effectiveness of the administration of antivenom for treatment...
2014: Journal of Intensive Care
https://www.readbyqxmd.com/read/25569252/cost-effectiveness-of-antivenoms-for-snakebite-envenoming-in-nigeria
#9
Abdulrazaq G Habib, Mohammed Lamorde, Mahmood M Dalhat, Zaiyad G Habib, Andreas Kuznik
BACKGROUND: Snakebite envenoming is a major public health problem throughout the rural tropics. Antivenom is effective in reducing mortality and remains the mainstay of therapy. This study aimed to determine the cost-effectiveness of using effective antivenoms for Snakebite envenoming in Nigeria. METHODOLOGY: Economic analysis was conducted from a public healthcare system perspective. Estimates of model inputs were obtained from the literature. Incremental Cost Effectiveness Ratios (ICERs) were quantified as deaths and Disability-Adjusted-Life-Years (DALY) averted from antivenom therapy...
January 2015: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/25361165/comparison-of-f-ab-2-versus-fab-antivenom-for-pit-viper-envenomation-a-prospective-blinded-multicenter-randomized-clinical-trial
#10
RANDOMIZED CONTROLLED TRIAL
Sean P Bush, Anne-Michelle Ruha, Steven A Seifert, David L Morgan, Brandon J Lewis, Thomas C Arnold, Richard F Clark, William J Meggs, Eric A Toschlog, Stephen W Borron, Gary R Figge, Dawn R Sollee, Farshad M Shirazi, Robert Wolk, Ives de Chazal, Dan Quan, Walter García-Ubbelohde, Alejandro Alagón, Richard D Gerkin, Leslie V Boyer
BACKGROUND: Crotalidae Polyvalent Immune Fab (Ovine) has been the only antivenom commercially available in the US since 2007 for treatment of Crotalinae envenomation. Late coagulopathy can occur or recur after clearance of Fab antivenom, often after hospital discharge, lasting in some cases more than 2 weeks. There have been serious, even fatal, bleeding complications associated with recurrence phenomena. Frequent follow-up is required, and additional intervention or hospitalization is often necessary...
January 2015: Clinical Toxicology
https://www.readbyqxmd.com/read/25341425/severe-adverse-drug-reaction-following-crotalidae-polyvalent-immune-fab-ovine-administration-for-copperhead-snakebite
#11
Maryjoy R Lepak, Samantha H Bochenek, Sean P Bush
OBJECTIVE: To present the case of a severe anaphylactic/anaphylactoid reaction to Crotalidae Polyvalent Immune Fab (Ovine) in a patient bitten by a copperhead snake. CASE SUMMARY: A 68-year-old man presented with progressive envenomation after receiving a copperhead snakebite on each hand. Crotalinae Fab antivenom was administered. While the initial and only dose was partially infusing, the patient developed an adverse drug reaction (ADR) of urticaria and hypotension, which resolved with cessation of the infusion, recurred with resumption of the infusion, and ultimately was completed with supportive care...
January 2015: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/25340841/current-treatment-for-venom-induced-consumption-coagulopathy-resulting-from-snakebite
#12
Kalana Maduwage, Geoffrey K Isbister
Venomous snakebite is considered the single most important cause of human injury from venomous animals worldwide. Coagulopathy is one of the commonest important systemic clinical syndromes and can be complicated by serious and life-threatening haemorrhage. Venom-induced consumption coagulopathy (VICC) is the commonest coagulopathy resulting from snakebite and occurs in envenoming by Viperid snakes, certain elapids, including Australian elapids, and a few Colubrid (rear fang) snakes. Procoagulant toxins activate the clotting pathway, causing a broad range of factor deficiencies depending on the particular procoagulant toxin in the snake venom...
October 2014: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/25119250/the-toxicology-investigators-consortium-case-registry-the-2013-experience
#13
Sean H Rhyee, Lynn Farrugia, Timothy Wiegand, Eric A Smith, Paul M Wax, Jeffrey Brent
The Toxicology Investigators Consortium (ToxIC) Case Registry was established in 2010 by the American College of Medical Toxicology. The Registry includes all medical toxicology consultations performed at participating sites. This report summarizes the Registry data for 2013. A query of the ToxIC Registry was carried out for the dates of January 1 through December 31, 2013. Specific data reviewed for analysis included demographics (age, gender), source of consultation, reasons for consultation, agents involved in toxicological exposures, signs, symptoms and clinical findings, and treatment...
December 2014: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/24999282/randomized-controlled-trial-of-intravenous-antivenom-versus-placebo-for-latrodectism-the-second-redback-antivenom-evaluation-rave-ii-study
#14
RANDOMIZED CONTROLLED TRIAL
Geoffrey K Isbister, Colin B Page, Nicholas A Buckley, Daniel M Fatovich, Ovidiu Pascu, Stephen P J MacDonald, Leonie A Calver, Simon G A Brown
STUDY OBJECTIVE: Latrodectism is the most important spider envenomation syndrome worldwide. There remains considerable controversy over antivenom treatment. We aimed to investigate whether antivenom resulted in resolution of pain and systemic effects in patients with latrodectism who received standardized analgesia. METHODS: In a multicenter randomized placebo-controlled trial of redback spider antivenom for latrodectism, 224 patients (>7 years) with a redback spider bite and severe pain, with or without systemic effects, were randomized to receive normal saline solution (placebo) or antivenom after receiving standardized analgesia...
December 2014: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/24891523/a-camelid-antibody-candidate-for-development-of-a-therapeutic-agent-against-hemiscorpius-lepturus-envenomation
#15
Najmeh Yardehnavi, Mahdi Behdani, Kamran Pooshang Bagheri, Amir Mahmoodzadeh, Hossein Khanahmad, Delavar Shahbazzadeh, Mahdi Habibi-Anbouhi, Gholamreza Hassanzadeh Ghassabeh, Serge Muyldermans
Hemiscorpius lepturus scorpionism poses one of the most dangerous health problems in many parts of the world. The common therapy consists of using antivenom antibody fragments derived from a polyclonal immune response raised in horses. However, this immunotherapy creates serious side effects, including anaphylactic shock sometimes even leading to death. Thus, many efforts have been made to introduce new replacement therapeutics that cause less adverse reactions. One of the most attractive approaches to replacing the available therapy is offered by single-domain antibody fragments, or nanobodies (Nbs)...
September 2014: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/24741911/mechanism-of-vipera-berus-venom-activity-and-the-principles-of-antivenom-administration-in-treatment
#16
REVIEW
Urszula Czajka, Aldona Wiatrzyk, Anna Lutyńska
In the present paper, the actual knowledge on the composition and toxic properties of the European common viper venom was analyzed. The organism response to the particular components and the methods of neutralization of venom toxin in bitten person were presented. On the basis of literature data, the clinical course of envenomation with its classification according to the severity of symptoms was characterized. In the paper the situations in which administration of antivenom is required to neutralize toxic properties of venom and its possible adverse reactions were also described...
2013: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/24550184/efficacy-of-scorpion-antivenom-plus-prazosin-versus-prazosin-alone-for-mesobuthus-tamulus-scorpion-sting-envenomation-in-children-a-randomised-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Karuppiah Pandi, Sriram Krishnamurthy, Rangan Srinivasaraghavan, Subramanian Mahadevan
OBJECTIVE: To assess the efficacy of combined use of scorpion antivenom (SAV) with prazosin, compared with prazosin alone in children with Mesobuthus tamulus scorpion envenomation. STUDY DESIGN: Randomised controlled trial. SETTING: A tertiary care hospital in south India. PATIENTS: 50 children with definite history and/or systemic manifestations of scorpion envenomation were recruited from the paediatric emergency or outpatient department from February 2012 to July 2013...
June 2014: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/24445201/anticomplementary-activity-of-horse-igg-and-f-ab-2-antivenoms
#18
Carla Cristina Squaiella-Baptistão, José Roberto Marcelino, Luiz Eduardo Ribeiro da Cunha, José María Gutiérrez, Denise V Tambourgi
Envenomation by poisonous animals is a neglected condition according to the World Health Organization (WHO). Antivenoms are included in the WHO Essential Medicines List. It has been assumed that immunoglobulin G (IgG) antivenoms could activate the complement system through Fc and induce early adverse reactions (EARs). However, data in the literature indicate that F(ab')2 fragments can also activate the complement system. Herein, we show that several batches of IgG and F(ab')2 antivenoms from the Butantan, Vital Brazil, and Clodomiro Picado Institutes activated the complement classical pathway and induced the production of C3a; however, only those antivenoms from Clodomiro Picado generated C5a...
March 2014: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/24396245/adverse-drug-reaction-profile-of-anti-snake-venom-in-a-rural-tertiary-care-teaching-hospital
#19
Rushikesh Prabhakar Deshpande, Vijay Motiram Motghare, Sudhir Laxman Padwal, Rakesh Ramkrishna Pore, Chetanraj Ghanshyam Bhamare, Vinod Shivaji Deshmukh, Harshal Nutan Pise
OBJECTIVES: The study was carried out with the aim of evaluation of the adverse drug reaction profile of anti-snake venom serum (ASV) in a rural tertiary care hospital. METHODS: An observational study was conducted in SRTR Medical College, Ambajogai, Maharashtra, India. A total number of 296 indoor case papers of snake bite from February to September 2011 and June to August 2012 were retrieved from the record section and the antivenom reactions were assessed. In addition, basic epidemiological data and prescribing practices of ASV were also analyzed...
June 2013: Journal of Young Pharmacists: JYP
https://www.readbyqxmd.com/read/24246428/single-reagent-one-step-procedures-for-the-purification-of-ovine-igg-f-ab-2-and-fab-antivenoms-by-caprylic-acid
#20
Ibrahim Al-Abdulla, Nicholas R Casewell, John Landon
Antivenoms are typically produced in horses or sheep and often purified using salt precipitation of immunoglobulins or F(ab')2 fragments. Caprylic (octanoic) acid fractionation of antiserum has the advantage of not precipitating the desired antibodies, thereby avoiding potential degradation that can lead to the formation of aggregates, which may be the cause of some adverse reactions to antivenoms. Here we report that when optimising the purification of immunoglobulins from ovine antiserum raised against snake venom, caprylic acid was found to have no effect on the activity of the enzymes pepsin and papain, which are employed in antivenom manufacturing to digest immunoglobulins to obtain F(ab')2 and Fab fragments, respectively...
January 15, 2014: Journal of Immunological Methods
keyword
keyword
106627
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"