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https://www.readbyqxmd.com/read/29679441/feasibility-safety-and-outcome-of-recanalisation-treatment-in-childhood-stroke
#1
Sandra Bigi, Andrea Dulcey, Jan Gralla, Corrado Bernasconi, Amber Melliger, Alexandre N Datta, Marcel Arnold, Johannes Kaesmacher, Joel Fluss, Annette Hackenberg, Oliver Maier, Johannes Weber, Claudia Poloni, Urs Fischer, Maja Steinlin
Objective Intravenous thrombolysis and endovascular therapy (IVT/EVT) are evidence-based treatments for adults with arterial ischemic stroke (AIS). However, randomized controlled trials in pediatric patients are lacking. This study aimed to describe feasibility, safety, and outcome of IVT/EVT in children with AIS. Methods Retrospective study (01/2000-12/2015) of a multicenter, population-based consecutive cohort of patients aged 1 month - 16 years diagnosed with AIS presenting with a pedNIHSS ≥4. Clinical and radiological data of patients receiving IVT/EVT were compared to those receiving standard care (SC) using linear regression to adjust for potential confounders...
April 20, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29675070/frequency-and-outcome-of-acute-neurologic-complications-after-congenital-heart-disease-surgery
#2
Sidra Kaleem Jafri, Lubaina Ehsan, Qalab Abbas, Fatima Ali, Prem Chand, Anwar Ul Haque
Objectives: To determine the frequency and immediate outcome of acute neurologic complications (ANCs) in children undergoing congenital heart surgery (CHS). Materials and Methods: In this retrospective study, all patients undergoing CHS at our hospital from January 2007 to June 2016 were included. Patients were followed up for the development of seizures, altered level of consciousness (ALOC), abnormal movements, and stroke. Results are presented as mean with standard deviation and frequency with percentages...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29675069/moyamoya-vasculopathy-in-indian-children-our-experience
#3
Varsha Anant Patil, Shilpa Dattaprasanna Kulkarni, Chandrashekhar E Deopujari, Naresh K Biyani, Anaita H Udwadia-Hegde, Krishnakumar N Shah
Background: Moyamoya vasculopathy is a chronic progressive vaso-occlusive disease affecting the distal intracranial carotid arteries and their proximal branches. It is an important cause of recurrent strokes in children. Surgical revascularization procedures are now considered as the treatment option for moyamoya vasculopathy. The data from Indian children with moyamoya vasculopathy are limited to a very few studies. Study Design: We analyzed the records of children with moyamoya vasculopathy treated at our tertiary care center from 2000 to 2014...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29673287/pediatric-stroke-rates-over-17-years-report-from-a-population-based-study
#4
Laura L Lehman, Jane C Khoury, J Michael Taylor, Samrat Yeramaneni, Heidi Sucharew, Kathleen Alwell, Charles J Moomaw, Katrina Peariso, Matthew Flaherty, Pooja Khatri, Joseph P Broderick, Brett M Kissela, Dawn O Kleindorfer
We previously published rates of pediatric stroke using our population-based Greater Cincinnati Northern Kentucky Stroke Study (GCNK) for periods July 1993-June 1994 and 1999. We report population-based rates from 2 additional study periods: 2005 and 2010. We identified all pediatric strokes for residents of the GCNK region that occurred in July 1, 1993-June 30, 1994, and calendar years 1999, 2005, and 2010. Stroke cases were ascertained by screening discharge ICD-9 codes, and verified by a physician. Pediatric stroke was defined as stroke in those <20 years of age...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29672747/stress-in-patients-with-un-ruptured-intracranial-aneurysms-vs-population-based-controls
#5
Arno de Wilde, Paut Greebe, Gabriël J E Rinkel, Ale Algra
BACKGROUND: Stress is associated with increased risk of stroke and might predispose to presence and rupture of intracranial aneurysms. OBJECTIVE: To study the association of recent and lifelong stress with unruptured intracranial aneurysm (UIA) and aneurysmal subarachnoid hemorrhage (ASAH). METHODS: In 227 UIA patients (mean age 61 ± 11 yr), 490 ASAH patients (59 ± 11 yr), and 775 controls (51 ± 15 yr) who were randomly retrieved from the general population, we assessed occurrence of major life events and perceived stress during the preceding 12 mo and the entire life...
April 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29668544/splenectomy-to-optimize-hemoglobin-s-control-in-children-with-sickle-cell-anemia-on-chronic-transfusion-therapy-for-stroke-prevention
#6
L Vandy Black, Jolie S Ramesar, Catherine H Boston
Chronic transfusion therapy with the goal of maintaining a hemoglobin (Hb) S <30% is the primary recommended treatment for children with sickle cell anemia and a history of overt stroke or abnormal transcranial Doppler examination. We report chronic hypersplenism as a cause of poor HbS% control in 3 children on chronic transfusion therapy for stroke prevention. Splenectomy resulted in a 39.77% (95% confidence interval, 34.3-45.3, P<0.0001) mean reduction in HbS% with no perioperative or infectious complications suggesting the need for additional research into splenectomy as a therapeutic option for select high-risk children to optimize transfusion therapy for stroke prevention...
April 17, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29666887/reversible-lesions-of-the-corpus-callosum-with-initially-restricted-diffusion-in-a-series-of-caucasian-children
#7
Anthony Le Bras, Maia Proisy, Mathieu Kuchenbuch, Constantin Gomes, Catherine Tréguier, Sylvia Napuri, Emmanuel Quehen, Bertrand Bruneau
BACKGROUND: Reversible lesions of the corpus callosum with initial restricted diffusion on diffusion-weighted imaging (DWI) are rare and mainly described in the south Asiatic population. OBJECTIVE: The purpose of this study was to describe the clinical presentation, imaging findings, prognosis and etiology of transient restricted diffusion lesions of the corpus callosum in a series of Caucasian children. MATERIALS AND METHODS: Seven children presenting with a transient restricted DWI lesion of the corpus callosum were included...
April 17, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29655630/is-varicella-vaccination-associated-with-pediatric-arterial-ischemic-stroke-a-population-based-cohort-study
#8
Shannon E MacDonald, Douglas C Dover, Michael D Hill, Adam Kirton, Kimberley A Simmonds, Lawrence W Svenson
BACKGROUND AND PURPOSE: Varicella disease is a risk factor for pediatric Arterial Ischemic Stroke (AIS). Isolated case reports have emerged suggesting that varicella vaccination may also pose a risk for AIS. METHODS: This retrospective population-based cohort study assessed the risk of AIS in children who received a varicella-containing vaccine, as compared to those who did not. The study cohort consisted of children born between January 1, 2006 and December 31, 2013, in the Canadian province of Alberta, where all routine childhood vaccinations are publicly-funded, and recorded in a central immunization repository...
April 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29651510/-vomiting-and-collapse-of-a-28-year-old-male-long-distance-runner-in-middle-european-summer
#9
J Herold, A Mitrasch, E Lorenz, U Lodes, I Tanev, R Braun-Dullaeus, F Meyer
BACKGROUND: Hyperthermia often ends fatally and must therefore be promptly recognized and adequately treated. CASE: A 28-year-old man participated in a long-distance race (3 km) on a hot summer day (28 °C). The runner collapsed, had to vomit but continued the run and reached the finish. Neurologically, the patient presented with intermittent cerebral seizures. External cooling batteries were immediately applied and cold infusions were started. The patient was admitted to the intensive care unit of the university hospital (body temperature 40...
April 12, 2018: Der Internist
https://www.readbyqxmd.com/read/29648667/epidemiology-risk-factors-and-characteristics-of-pediatric-stroke-a-nationwide-population-based-study
#10
Kuo-Liang Chiang, Chen-Yang Cheng
Background: Stroke, classically characterized as an acute acquired neurological deficit, is an important leading cause of death and chronic morbidity in children. Aims: This study reported the period prevalence, incidence, and risk factors of pediatric stroke in Taiwan. Methods and Procedures: All Taiwan inhabitants aged 1 month to 18 years registered in the National Health Insurance Research Database (NHIRD) between 2010 and 2011 were enrolled in this study...
April 10, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29627811/global-epidemiology-and-patterns-of-cerebral-venous-thrombosis-a-systematic-review-and-meta-analysis-protocol
#11
Celestin Danwang, Temgoua Ngou Mazou, Joël Noutakdie Tochie, Ronni Tankeu, Jean Joel Bigna
INTRODUCTION: Venous thrombosis can affect all veins in the body including cerebral veins, where it causes cerebral venous thrombosis (CVT). CVT is an aetiology of stroke, particularly in children and young adults. Its clinical features vary widely according to the occluded vessel. Data concerning the epidemiology of CVT are scant. This protocol for a systematic review and meta-analysis aims to critically synthesise data concerning prevalence, incidence, risk factors, anatomical patterns, diagnostic and therapeutic delays, and mortality rate of CVT in the global population...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29627789/late-recanalization-of-basilar-artery-occlusion-in-a-previously-healthy-17-month-old-child
#12
D Andrew Wilkinson, Aditya S Pandey, Hugh J Garton, Luis Savastano, Julius Griauzde, Neeraj Chaudhary, Joseph J Gemmete
Endovascular treatment of acute ischemic stroke in children is increasingly being reported, although the time window for intervention is unclear. We describe a previously healthy 17-month-old child who presented with vertebral artery thrombosis and cerebellar stroke requiring posterior fossa decompression. She later progressed to basilar artery thrombosis treated with mechanical thrombectomy 50 hours after clinical decline. At 3 month follow-up, the patient had a modified Rankin Scale score of 0.
April 7, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29626133/long-term-risk-of-hemorrhagic-stroke-in-young-patients-with-congenital-heart-disease
#13
Kok Wai Giang, Zacharias Mandalenakis, Mikael Dellborg, Georgios Lappas, Peter Eriksson, Per-Olof Hansson, Annika Rosengren
BACKGROUND AND PURPOSE: The risk of ischemic stroke is increased in patients with congenital heart disease (CHD); however, data on the risk of hemorrhagic stroke, including intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH), are lacking. METHODS: The Swedish Patient Register was used to identify all patients who were born with a diagnosis of CHD between 1970 and 1993. Each patient was compared with 10 randomly selected controls from the general population, matched for age, sex, and county...
April 6, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29624666/manual-dexterity-but-not-cerebral-palsy-predicts-cognitive-functioning-after-neonatal-stroke
#14
Guillaume Thébault, Sophie Martin, Denis Brouillet, Lionel Brunel, Mickaël Dinomais, Émilie Presles, Joel Fluss, Stéphane Chabrier
AIM: To disentangle the respective impacts of manual dexterity and cerebral palsy (CP) in cognitive functioning after neonatal arterial ischaemic stroke. METHOD: The population included 60 children (21 females, 39 males) with neonatal arterial ischaemic stroke but not epilepsy. The presence of CP was assessed clinically at the age of 7 years and 2 months (range 6y 11mo-7y 8mo) using the definition of the Surveillance of CP in Europe network. Standardized tests (Nine-Hole Peg Test and Box and Blocks Test) were used to quantify manual (finger and hand respectively) dexterity...
April 6, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29616203/non-invasive-brain-stimulation-in-children-with-unilateral-cerebral-palsy-a-protocol-and-risk-mitigation-guide
#15
Bernadette T Gillick, Andrew M Gordon, Tim Feyma, Linda E Krach, Jason Carmel, Tonya L Rich, Yannick Bleyenheuft, Kathleen Friel
Non-invasive brain stimulation has been increasingly investigated, mainly in adults, with the aims of influencing motor recovery after stroke. However, a consensus on safety and optimal study design has not been established in pediatrics. The low incidence of reported major adverse events in adults with and without clinical conditions has expedited the exploration of NIBS in children with paralleled purposes to influence motor skill development after neurological injury. Considering developmental variability in children, with or without a neurologic diagnosis, adult dosing and protocols may not be appropriate...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29605352/open-resection-and-laryngotracheal-reconstruction-in-a-case-of-subglottic-hemangioma-in-phace-syndrome
#16
Laura A Petrauskas, Vilija J Vaitaitis, Gerhard Mundinger, Claudie Sheahan, Jeffrey Poole, Sohit Paul Kanotra
We describe a 1 month old infant with PHACE syndrome who underwent successful management of subglottic hemangioma by open resection and laryngotracheal reconstruction using a thyroid ala graft. Propranolol is typically the treatment of choice for subglottic hemangiomas however, recent reports have suggested adverse complications with the use of propranolol in children with PHACE syndrome. The child had cerebral and cervical vascular anomalies associated with her PHACE syndrome making her at an increased risk of stroke with the use of propranolol...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29602053/eeg-findings-and-outcomes-of-continuous-video-eeg-monitoring-started-prior-to-initiation-of-seizure-treatment-in-the-perinatal-stroke
#17
José R Castro Conde, Itziar Quintero Fuentes, Candelaria González Campo, Alejandro Jiménez Sosa, Beatriz Reyes Millán, Sergio Hernández Expósito
BACKGROUND: To analyze the findings in the background EEG activity of infants who suffered perinatal stroke. METHODS: Eleven neonates born 2009-2014 diagnosed of ischemic stroke by MRI (three of them with multistroke) underwent continuous video-EEG monitoring. Visual and spectral (power spectrum and coherence) analyses of the background EEG was performed in three moments: 1) Onset of EEG recording (prior to initiate seizure treatment), 2) Post-ictal epoch (1-2 h after the last seizure), and 3) one-two days after seizure control...
March 27, 2018: Early Human Development
https://www.readbyqxmd.com/read/29598907/upstream-stimulating-factor-1-usf-1-gene-polymorphisms-and-the-risk-symptoms-and-outcome-of-pediatric-ischemic-stroke
#18
Anna Balcerzyk, Paweł Niemiec, Tomasz Iwanicki, Tomasz Nowak, Ilona Kopyta, Ewa Emich-Widera, Ewa Pilarska, Karolina Pienczk-Ręcławowicz, Marek Kaciński, Janusz Wendorff, Sylwia Górczyńska-Kosiorz, Władyslaw Grzeszczak, Iwona Żak
BACKGROUND: Pediatric ischemic stroke is an important cause of morbidity and mortality. As previous studies of children after stroke showed, dyslipidemias were very common in Polish and other European populations. Thus, looking for genetic factors predisposing to pediatric stroke, its symptoms, and outcome, we have analyzed 2 polymorphisms of the upstream stimulating factor 1 (USF-1) gene. MATERIALS AND METHODS: The study group consisted of 82 children with stroke, 156 parents, and 146 controls...
March 26, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29595632/refractory-mycoplasma-pneumoniae-pneumonia-with-concomitant-acute-cerebral-infarction-in-a-child-a-case-report-and-literature-review
#19
REVIEW
Xingnan Jin, Yingxue Zou, Jia Zhai, Jie Liu, Bing Huang
RATIONALE: Mycoplasma pneumoniae pneumonia, a common cause of community-acquired pneumonia in children, is rarely complicated with acute cerebral infarction. PATIENT CONCERNS: We present a 7-year-old boy with severe M pneumoniae pneumonia who developed impaired consciousness, aphasia, and reduced limb muscle power 7 days postadmission. DIAGNOSES: Mycoplasma pneumoniae pneumonia with concomitant acute cerebral infarction. INTERVENTIONS: The patient recovered with aggressive antibiotic therapy, antiinflammation therapy with methylprednisolone, and gamma immunoglobulin and anticoagulation therapy with aspirin and low molecular weight heparin along with rehabilitation training...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29594504/management-of-high-blood-pressure-in-children-similarities-and-differences-between-us-and-european-guidelines
#20
Tammy M Brady, Amalia Stefani-Glücksberg, Giacomo D Simonetti
Over the last several decades, many seminal longitudinal cohort studies have clearly shown that the antecedents to adult disease have their origins in childhood. Hypertension (HTN), which has become increasingly prevalent in childhood, represents one of the most important risk factors for cardiovascular diseases (CVD) such as heart disease and stroke. With the risk of adult HTN much greater when HTN is manifest in childhood, the future burden of CVD worldwide is therefore concerning. In an effort to slow the current trajectory, professional societies have called for more rigorous, evidence-based guideline development to aid primary care providers and subspecialists in improving recognition, diagnosis, evaluation, and treatment of pediatric HTN...
March 28, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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