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Shingles vaccine

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https://www.readbyqxmd.com/read/29771876/quickstats-percentage-of-adults-aged-%C3%A2-60-years-who-ever-had-the-shingles-vaccine-by-sex-national-health-interview-survey-2008-2016-%C3%A2
#1
(no author information available yet)
No abstract text is available yet for this article.
May 18, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29743372/-breadth-and-functionality-of-varicella-zoster-virus-glycoprotein-specific-antibodies-identified-after-zostavax-vaccination-in-humans
#2
Nicole L Sullivan, Morgan A Reuter-Monslow, Janet Sei, Eberhard Durr, Carl W Davis, Cathy Chang, Megan McCausland, Andreas Wieland, David Krah, Nadine Rouphael, Aneesh K Mehta, Mark J Mulligan, Bali Pulendran, Rafi Ahmed, Kalpit A Vora
Herpes zoster (HZ/shingles) is the clinical manifestation of varicella zoster virus (VZV) reactivation. HZ typically develops as people age due to decreased cell-mediated immunity. However, the importance of antibodies for immunity against HZ prevention remains to be understood. The goal of this study was to examine the breadth and functionality of VZV-specific antibodies after vaccination with a live attenuated HZ vaccine (Zostavax). Direct enumeration of VZV-specific antibody secreting cells (ASC) via ELISPOT showed that Zostavax can induce both IgG and IgA ASCs seven days after vaccination, but not IgM ASCs...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29730833/assessing-and-improving-zoster-vaccine-uptake-in-a-homeless-population
#3
Laura Kaplan-Weisman, Eve Waltermaurer, Casey Crump
The herpes zoster (shingles) vaccine is recommended for all adults aged ≥ 60 years without contraindications to prevent shingles and post-herpetic neuralgia. There are no published studies on zoster vaccination rates, barriers, or workflows in adults who have experienced homelessness. Due to barriers specific to this vaccine, including difficulty determining insurance coverage, high upfront costs, need for storage in a freezer, and under-prescription by physicians, uptake is lower compared to other recommended vaccines for older adults...
May 5, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29720364/monitoring-interest-in-herpes-zoster-vaccination-analysis-of-google-search-data
#4
Elyse J Berlinberg, Michael S Deiner, Travis C Porco, Nisha R Acharya
BACKGROUND: A new recombinant subunit vaccine for herpes zoster (HZ or shingles) was approved by the United States Food and Drug Administration on October 20, 2017 and is expected to replace the previous live attenuated vaccine. There have been low coverage rates with the live attenuated vaccine (Zostavax), ranging from 12-32% of eligible patients receiving the HZ vaccine. OBJECTIVE: This study aimed to provide insight into trends and potential reasons for interest in HZ vaccination...
May 2, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29653205/varicella-zoster-virus-reactivation-in-adult-survivors-of-hematopoietic-cell-transplantation-how-do-we-best-protect-our-patients
#5
REVIEW
Catherine J Lee, Bipin N Savani, Per Ljungman
Reactivation of varicella zoster virus (VZV) remains a significant public health burden for long-term survivors of hematopoietic cell transplantation. Delayed immune reconstitution after transplantation due to immunosuppression, posttransplant therapies, poor engraftment, and graft-versus-host disease leave a large number of patients at risk for herpes zoster (shingles) and its highly morbid complications. Although prophylaxis with acyclovir or valacyclovir has reduced the incidence of VZV reactivation as long as prophylaxis is continued, the incidence of disease in the late posttransplant period or after stopping prophylaxis is greater in the HCT population than the general public...
April 10, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29580194/post-licensure-safety-surveillance-of-zoster-vaccine-live-zostavax%C3%A2-in-the-united-states-vaccine-adverse-event-reporting-system-vaers-2006-2015
#6
Elaine R Miller, Paige Lewis, Tom T Shimabukuro, John Su, Pedro Moro, Emily Jane Woo, Christopher Jankosky, Maria Cano
BACKGROUND: Herpes zoster (HZ), or shingles, is caused by reactivation of varicella-zoster virus in latently infected individuals. Live-attenuated HZ vaccine (zoster vaccine live, ZVL) is approved in the United States for persons aged ≥50 years and recommended by the CDC for persons ≥60 years. METHODS: We analyzed U.S. reports of adverse events (AEs) following ZVL submitted to the Vaccine Adverse Event Reporting System (VAERS), a spontaneous reporting system to monitor vaccine safety, for persons vaccinated May 1, 2006, through January 31, 2015...
March 26, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29565203/management-of-herpes-zoster-shingles-during-pregnancy
#7
Khalea Hayward, Abigail Cline, Angela Stephens, Linda Street
An infection with the varicella-zoster virus (VZV) causes both varicella and herpes zoster (HZ). Although rare, the development of HZ does occur during pregnancy. Maternal HZ does not result in increased foetal mortality, and the passage of VZV to the foetus rarely occurs. However, HZ does increase maternal morbidity. Upon infection with HZ, patients typically present with a viral prodrome preceding the appearance of the characteristic zoster rash. HZ is usually diagnosed clinically by the zoster rash, but can also be confirmed by a polymerase chain reaction and an enzyme-linked immunosorbent assay...
March 22, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29548545/a-new-more-effective-vaccine-to-prevent-shingles
#8
William Simonson
No abstract text is available yet for this article.
March 13, 2018: Geriatric Nursing
https://www.readbyqxmd.com/read/29528885/acute-retinal-necrosis-and-contralateral-cutaneous-eruption-after-the-shingles-vaccine
#9
Amro Ali, Malka Davina Kirschenbaum, Sansar Sharma, Thaddeus L Wandel
PURPOSE: To the best of our knowledge, we present a rare case report describing an occurrence of acute retinal necrosis in an otherwise healthy individual who received the shingles vaccine. METHODS: Observational case report. PATIENT: A 63-year-old healthy and immunocompetent white man presented with change of vision in the left eye after blunt trauma. A diagnosis of corneal abrasion was made. During follow-up, a detailed history discovered a progressive deterioration in vision over the past few weeks...
March 8, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29512282/a-randomized-placebo-controlled-phase-i-trial-of-live-attenuated-herpes-zoster-vaccine-in-subjects-with-end-stage-renal-disease-immunized-prior-to-renal-transplantation
#10
Geraldine Miller, Heidi Schaefer, Sandra Yoder, Rachel Miller, Patricia Winokur, Karen Kotloff, David Klassen, Michael Wierzbicki, Cyrille Amegashie, Kathryn Edwards
BACKGROUND: Solid organ transplant recipients are at increased risk for reactivation of herpes zoster, or shingles, and have a higher frequency of serious complications including post-herpetic neuralgia. A live, attenuated shingles vaccine is effective and approved for individuals 50 years and older. The vaccine is contraindicated following transplantation, but may be used in patients with renal failure. Utilization of the vaccine has been poor in patients with end-stage renal disease, including those awaiting transplant, owing to concerns for safety, efficacy, and potential sensitization prior to transplant...
March 7, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29509821/practice-alert-acip-vaccine-update
#11
Doug Campos-Outcalt
The Advisory Committee on Immunization Practices made relatively few new vaccine recommendations in 2017. One pertained to prevention of hepatitis B virus infection in infants born to HBV-infected mothers. Another recommended a new vaccine to prevent shingles. A third advised considering an additional dose of mumps vaccine during an outbreak.
March 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29503961/shingles-as-the-underlying-cause-of-orbital-myositis-in-an-adolescent-a-case-report
#12
Christopher D Conrady, Richard M Feist, Alison Crum
Purpose: Orbital myositis is characterized by pain with eye movements, gaze restriction, diplopia, and enlargement of extraocular muscles on imaging. Varicella zoster virus (VZV) is an extremely rare cause of the disease in the elderly and has never been reported in a patient younger than forty-five years old such as the adolescent described herein. We present this case to raise awareness of an entity that will likely become more prevalent due to current vaccine strategies. Observation: We present the case of a 13-year-old girl with VZV-associated orbital myositis and meningitis that had a quick and complete recovery following IV acyclovir and oral steroids...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29498740/varicella-zoster-virus-infection-natural-history-clinical-manifestations-immunity-and-current-and-future-vaccination-strategies
#13
Giulia Freer, Mauro Pistello
Varicella-zoster virus (VZV) is the etiologic agent of varicella (chicken pox), a childhood exanthematic disease that develops as a result of primary infection, and zoster (shingles), caused by reactivation of the virus persisting in a latent form in the dorsal sensory ganglia. Although varicella is generally a mild self-limiting illness, in immunocompromised subjects and adults it can have a serious clinical course that can lead to permanent damage of the central nervous system. In these and in most zoster cases, treatment with anti-herpetic drugs and/or immunotherapy is necessary...
March 2, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29491694/pharmaceutical-approval-update
#14
Michele B Kaufman
Zoster vaccine recombinant, adjuvanted (Shingrix) for the prevention of shingles in adults; angiotensin II injection (Giapreza) to increase blood pressure in adults with septic or other distributive shock; and glycopyrrolate inhalation solution (Lonhala Magnair) for the maintenance treatment of chronic obstructive pulmonary disease.
March 2018: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29457489/shingrix-the-new-adjuvanted-recombinant-herpes-zoster-vaccine
#15
Stephanie F James, Elias B Chahine, Allana J Sucher, Cassandra Hanna
OBJECTIVES: To review the immunogenicity, efficacy, and safety of the herpes zoster subunit vaccine (HZ/su) for use in adult patients for the prevention of shingles. DATA SOURCES: A literature search through PubMed was conducted (June 2008 to October 2017) using the terms shingles vaccine and varicella zoster virus. References from retrieved articles and the prescribing information were also reviewed for any additional material. STUDY SELECTION/DATA EXTRACTION: The literature search was limited to human studies published in English...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29431387/herpes-zoster-and-postherpetic-neuralgia-prevention-and-management
#16
Aaron Saguil, Shawn Kane, Michael Mercado, Rebecca Lauters
Herpes zoster, or shingles, is caused by reactivation of varicella zoster virus, which causes chickenpox. There are an estimated 1 million cases in the Unites States annually, with an individual lifetime risk of 30%. Patients with conditions that decrease cell-mediated immunity are 20 to 100 times more likely to develop herpes zoster. Patients may present with malaise, headache, low-grade fever, and abnormal skin sensations for two to three days before the classic maculopapular rash appears. The rash is usually unilateral, confined to a single dermatome, and typically progresses to clear vesicles that become cloudy and crust over in seven to 10 days...
November 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29338438/challenges-in-adult-vaccination
#17
Eduardo de Gomensoro, Giuseppe Del Giudice, T Mark Doherty
Life-long primary prevention interventions beginning and continuing throughout an individual's lifetime are increasingly seen as key to meeting the global healthcare challenges that accompany demographic changes - a concept referred to as "Healthy aging". In this perspective, vaccination is seen as part of a triad, together with healthy diet and exercise. Current adult vaccine coverage is lower than target vaccination rates in most developed countries, and so vaccine preventable diseases continue to present a substantial burden on health and healthcare resources, especially in older individuals...
May 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29242077/vaccine-type-mutations-identified-in-varicella-zoster-virus-passaged-in-cell-culture
#18
Seok Cheon Kim, Youn Hee Won, Ji Seon Park, Jeong Seon Jeon, Jin Hyun Ahn, Moon Jung Song, Ok Sarah Shin, Chan Hee Lee
Varicella-zoster virus (VZV) is a causative agent for chickenpox and shingles. Comparative genomic sequence analysis of clinical and vaccine strains suggested potential sites responsible for attenuation. In this study, low and high passages of two VZV clinical strains cultured in human fibroblast cells were compared for genomic DNA sequences and growth characteristics. Mutations were detected at 187 and 162 sites in the strain YC01 and YC02, respectively. More than 86% of mutations were found in open reading frames, and ORF62 exhibited highest frequency of mutations...
February 2, 2018: Virus Research
https://www.readbyqxmd.com/read/29216315/the-pul37-tegument-protein-guides-alpha-herpesvirus-retrograde-axonal-transport-to-promote-neuroinvasion
#19
Alexsia L Richards, Patricia J Sollars, Jared D Pitts, Austin M Stults, Ekaterina E Heldwein, Gary E Pickard, Gregory A Smith
A hallmark property of the neurotropic alpha-herpesvirinae is the dissemination of infection to sensory and autonomic ganglia of the peripheral nervous system following an initial exposure at mucosal surfaces. The peripheral ganglia serve as the latent virus reservoir and the source of recurrent infections such as cold sores (herpes simplex virus type I) and shingles (varicella zoster virus). However, the means by which these viruses routinely invade the nervous system is not fully understood. We report that an internal virion component, the pUL37 tegument protein, has a surface region that is an essential neuroinvasion effector...
December 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29173081/varicella-virus-vaccination-in-the-united-states
#20
Jana Shaw, Anne A Gershon
Varicella zoster virus (VZV) is the cause of chickenpox (varicella) and shingles (zoster), and was once responsible for over 4 million infections in the United States annually. The development of a live attenuated VZV vaccine was initially viewed with extreme skepticism. Nonetheless, a VZV vaccine was developed in the 1970s by Takahashi and his colleagues in Japan and was eventually licensed in the US. It is now known to be one of the safest and most effective vaccines available and is administered worldwide...
November 27, 2017: Viral Immunology
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