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https://www.readbyqxmd.com/read/28345492/rasburicase-induced-methemoglobinemia-the-eyes-do-not-see-what-the-mind-does-not-know
#1
Uroosa Ibrahim, Amina Saqib, Farhan Mohammad, Jean Paul Atallah, Marcel Odaimi
Rasburicase is indicated for the prevention and treatment of tumor lysis syndrome which can be a potentially life-threatening emergency. The drug has oxidizing potential and as an adverse effect, it can convert the ferrous form of iron in erythrocytes to its ferric form resulting in the formation of methemoglobin which makes the heme component incapable of carrying oxygen. Patients with glucose-6-phosphate dehydrogenase enzyme deficiency are at high risk of methemoglobinemia from oxidizing agents. Symptoms of methemoglobinemia range from none to life-threatening hypoxemia, cyanosis and respiratory compromise...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28343180/oxygen-saturation-trends-in-normal-healthy-term-newborns-normal-vaginal-delivery-vs-elective-cesarean-section
#2
Rashi Bhargava, Madhu Mathur, Jyoti Patodia
OBJECTIVES: To study the normal oxygen saturation trends and fetomaternal correlates in healthy term newborns within 30 min of life born by normal vaginal delivery (NVD) and elective cesarean section (CS). MATERIALS AND METHODS: A cross-sectional study was conducted on 200 healthy term newborns born by NVD and elective CS at a tertiary care centre. Routine care as per the Neonatal Resuscitation Program (NRP) 2015 (Wyckoff MH, Aziz K, Escobedo MB, Kapadia VS, Kattwinkel J, Perlman JM, et al...
March 27, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28339432/bipolar-versus-unipolar-intraarticular-pulsed-radiofrequency-thermocoagulation-in-chronic-knee-pain-treatment-a-prospective-randomized-trial
#3
Ersel Gulec, Hayri Ozbek, Sinan Pektas, Geylan Isik
BACKGROUND: Chronic knee pain is a major widespread problem causing significant impairment of daily function. Pulsed radiofrequency has been shown to reduce severe chronic joint pain as a non-pharmacological and less invasive treatment method. OBJECTIVE: We aimed to compare the effectiveness of unipolar and bipolar intraarticular pulsed radiofrequency methods in chronic knee pain control. STUDY DESIGN: Prospective, randomized, double-blind study...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28333321/preconception-and-early-pregnancy-maternal-haemodynamic-changes-in-healthy-women-in-relation-to-pregnancy-viability
#4
F L Foo, A Collins, C M McEniery, P R Bennett, I B Wilkinson, C C Lees
STUDY QUESTION: Are there differences in preconception cardiovascular function between women who have a viable pregnancy and those who have a first trimester miscarriage? SUMMARY ANSWER: Preconception cardiovascular function of central haemodynamics and arterial function are similar between women who have a viable pregnancy and those who have a first trimester miscarriage. WHAT IS KNOWN ALREADY: Miscarriages have been associated with increased long-term cardiovascular disease risk, and arterial and cardiovascular dysfunction has been hypothesised as the common link...
March 16, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28321493/the-costs-of-locomotor-activity-maximum-body-temperatures-and-the-use-of-torpor-during-the-active-season-in-edible-dormice
#5
Claudia Bieber, Jessica S Cornils, Franz Hoelzl, Sylvain Giroud, Thomas Ruf
Measuring T b during the active season can provide information about the timing of reproduction and the use of short bouts of torpor and may be used as a proxy for the locomotor activity of animals (i.e., maximum T b). This kind of information is especially important to understand life-history strategies and energetic costs and demands in hibernating mammals. We investigated T b throughout the active season in edible dormice (Glis glis), since they (i) have an expensive arboreal life-style, (ii) are known to show short bouts of torpor, and (iii) are adapted to pulsed resources (mast of beech trees)...
March 21, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28303441/association-between-health-literacy-and-hypertension-management-in-a-chinese-community-a-retrospective-cohort-study
#6
Di Shi, Jiangbo Li, Yong Wang, Si Wang, Kai Liu, Rufeng Shi, Qiang Zhang, Xiaoping Chen
Low health literacy is associated with poor clinical outcomes. The relationship between literacy and blood pressure (BP) has been inconsistent. We investigated the determinants of health literacy and the potential relationship between health literacy and hypertension management. We conducted a retrospective cohort trial of 360 hypertensive patients. Scale measurements, physical examination, and laboratory tests were performed based on a standard protocol. To determine factors associated with health literacy, multiple logistic regression analysis was performed and the discriminatory power of the scale score for hypertension control was assessed by the area under the receiver operating curve...
March 16, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28295793/evolutionary-diversification-of-the-auditory-organ-sensilla-in-neoconocephalus-katydids-orthoptera-tettigoniidae-correlates-with-acoustic-signal-diversification-over-phylogenetic-relatedness-and-life-history
#7
Johannes Strauß, Joscha A Alt, Klemens Ekschmitt, Johannes Schul, Reinhard Lakes-Harlan
Neoconocephalus tettigoniids are a model for the evolution of acoustic signals as male calls have diversified in temporal structure during the radiation of the genus. Tettigoniidae have hearing organs in the forelegs with species-specific numbers of auditory sensilla in a linear crista acustica. We investigated changes of the hearing organs during an evolutionary radiation with divergence of intraspecific acoustic signals. We compared the neuroanatomy of the crista acustica from 9 Neoconocephalus species with different temporal call features, life histories, and from different phylogenetic positions...
March 13, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28295341/exercise-training-reverses-age-induced-diastolic-dysfunction-and-restores-coronary-microvascular-function
#8
Kazuki Hotta, Bei Chen, Bradley J Behnke, Payal Ghosh, John N Stabley, Jeremy A Bramy, Jaime L Sepulveda, Michael D Delp, Judy M Muller-Delp
The risk for diastolic dysfunction increases with advancing age. Regular exercise training ameliorates age-related diastolic dysfunction; however, the underlying mechanisms have not been identified. We investigated whether 1) microvascular dysfunction contributes to the development of age-related diastolic dysfunction, and 2) initiation of late-life exercise training reverses age-related diastolic and microvascular dysfunction. Young and old rats underwent 10 weeks of exercise training or remained as sedentary, cage-controls...
March 10, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28287021/evaluation-of-a-static-stretching-intervention-on-vascular-endothelial-function-and-arterial-stiffness
#9
Hiromi Shinno, Satoshi Kurose, Yutaka Yamanaka, Kyoko Higurashi, Yaeko Fukushima, Hiromi Tsutsumi, Yutaka Kimura
PURPOSE: Maintenance and enhancement of vascular endothelial function contribute to the prevention of cardiovascular disease and prolong a healthy life expectancy. Given the reversible nature of vascular endothelial function, interventions to improve this function might prevent arteriosclerosis. Accordingly, we studied the effects of a 6-month static stretching intervention on vascular endothelial function (reactive hyperaemia peripheral arterial tonometry index: RH-PAT index) and arterial stiffness (brachial-ankle pulse wave velocity: baPWV) and investigated the reversibility of these effects after a 6-month detraining period following intervention completion...
March 13, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28280284/the-fiber-optic-system-for-the-advanced-topographic-laser-altimeter-system-atlas-instrument
#10
Melanie N Ott, Joe Thomes, Eleanya Onuma, Robert Switzer, Richard Chuska, Diana Blair, Erich Frese, Marc Matyseck
The Advanced Topographic Laser Altimeter System (ATLAS) Instrument has been in integration and testing over the past 18 months in preparation for the Ice, Cloud and Land Elevation Satellite - 2 (ICESat-2) Mission, scheduled to launch in 2017. ICESat-2 is the follow on to ICESat which launched in 2003 and operated until 2009. ATLAS will measure the elevation of ice sheets, glaciers and sea ice or the "cryosphere" (as well as terrain) to provide data for assessing the earth's global climate changes. Where ICESat's instrument, the Geo-Science Laser Altimeter (GLAS) used a single beam measured with a 70 m spot on the ground and a distance between spots of 170 m, ATLAS will measure a spot size of 10 m with a spacing of 70 cm using six beams to measure terrain height changes as small as 4 mm...
August 28, 2016: Proceedings of SPIE
https://www.readbyqxmd.com/read/28273173/relationships-between-lifestyle-patterns-and-cardio-renal-metabolic-parameters-in-patients-with-type-2-diabetes-mellitus-a-cross-sectional-study
#11
Takeshi Ogihara, Tomoya Mita, Yusuke Osonoi, Takeshi Osonoi, Miyoko Saito, Atsuko Tamasawa, Shiho Nakayama, Yuki Someya, Hidenori Ishida, Masahiko Gosho, Akio Kanazawa, Hirotaka Watada
INTRODUCTION: While individuals tend to show accumulation of certain lifestyle patterns, the effect of such patterns in real daily life on cardio-renal-metabolic parameters remains largely unknown. This study aimed to assess clustering of lifestyle patterns and investigate the relationships between such patterns and cardio-renal-metabolic parameters. PARTICIPANTS AND METHODS: The study participants were 726 Japanese type 2 diabetes mellitus (T2DM) outpatients free of history of cardiovascular diseases...
2017: PloS One
https://www.readbyqxmd.com/read/28270380/exacerbations-in-chronic-obstructive-pulmonary-disease-identification-and-prediction-using-a-digital-health-system
#12
Syed Ahmar Shah, Carmelo Velardo, Andrew Farmer, Lionel Tarassenko
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a progressive, chronic respiratory disease with a significant socioeconomic burden. Exacerbations, the sudden and sustained worsening of symptoms, can lead to hospitalization and reduce quality of life. Major limitations of previous telemonitoring interventions for COPD include low compliance, lack of consensus on what constitutes an exacerbation, limited numbers of patients, and short monitoring periods. We developed a telemonitoring system based on a digital health platform that was used to collect data from the 1-year EDGE (Self Management and Support Programme) COPD clinical trial aiming at daily monitoring in a heterogeneous group of patients with moderate to severe COPD...
March 7, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28268434/an-unsupervised-learning-for-robust-cardiac-feature-derivation-from-ppg-signals
#13
Soma Bandyopadhyay, Arijit Ukil, Chetanya Puri, Rituraj Singh, Arpan Pal, K M Mandana, C A Murthy
We propose here derivation algorithms for physiological parameters like beat start point, systolic peak, pulse duration, peak-to-peak distance related to heart rate, dicrotic minima, diastolic peak from Photoplethysmogram (PPG) signals robustly. Our methods are based on unsupervised learning mainly following morphology as well as discrete nature of the signal. Statistical learning has been used as a special aid to infer most probable feature values mainly to cope up with presence of noise, which is assumed to be insignificant compared to signal values at each investigation window...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267932/hemoglobin-is-a-vital-determinant-of-arterial-oxygen-content-in-hypoxemic-patients-with-pulmonary-arteriovenous-malformations
#14
Abeer Rizvi, Patricia Macedo, Lydia Babawale, Hannah C Tighe, J Michael B Hughes, James E Jackson, Claire L Shovlin
RATIONALE: Arterial partial pressure of oxygen (PaO2), and oxygen saturation (SaO2) are commonly measured in respiratory practice, but arterial oxygen content (CaO2) refers to the volume of oxygen delivered to the tissues per unit blood volume. CaO2 is calculated from SaO2 and the hemoglobin concentration in blood, recognizing that each gram of hemoglobin can transport approximately 1.34mls of oxygen when fully saturated. OBJECTIVES: To prospectively evaluate serial changes in CaO2 in man, incorporating and excluding dynamic changes to oxygenation and hemoglobin parameters that may occur during life...
March 7, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28263857/organ-donation-an-unexpected-benefit-of-aggressive-resuscitation-of-trauma-patients-presenting-dead-on-arrival
#15
Abdul Q Alarhayem, Stephen M Cohn, Mark T Muir, John G Myers, James Fuqua, Brian J Eastridge
BACKGROUND: We sought to determine if aggressive resuscitation in trauma patients presenting without vital signs or "dead on arrival" (DOA) was futile. We also sought to determine if organ donation was an unexpected benefit of aggressive resuscitation. STUDY DESIGN: We conducted a review of adults presenting to our Level 1 trauma center with no signs of life (pulse = 0; systolic blood pressure = 0; and no evidence of neurologic activity, GCS = 3). Primary outcome was survival to hospital discharge or major organ donation (heart, lung, kidney, liver or pancreas were harvested)...
March 2, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28260748/effect-of-obesity-on-fasting-blood-sugar
#16
R Akter, A Nessa, M F Husain, F Wahed, N Khatun, M Yesmin, S Nasreen, T Tajkia
Obesity is a disorder of body weight regulatory systems characterized by an accumulation of excess body fat. World Heath Organization recommended that 66% of deaths now occur in developing countries and recognizes obesity as a leading risk factor. Obesity is associated with chronic, low grade, systemic inflammation. The inflammatory state plays a causal role in the development of insulin resistance, type 2 diabetes and the metabolic syndrome. This study will design to evaluate the relation between obesity with fasting blood sugar (FBS)...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28251523/atypical-facial-pain-a-comprehensive-evidence-based-review
#17
REVIEW
Austin L Weiss, Ken P Ehrhardt, Reda Tolba
PURPOSE OF REVIEW: The purpose of this article is to focus on an excruciating disorder of the face, named atypical facial pain or persistent idiopathic facial pain (PIFP). It is considered an underdiagnosed condition with limited treatment options. Facial pain can be a debilitating disorder that affects patients' quality of life. Up to 26% of the general population has suffered from facial pain at some point in their lives. It is important to highlight the different types of facial pain to be able to properly manage this condition accordingly...
February 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28247666/-extracorporeal-shock-wave-therapy-in-chronic-prostatitis
#18
E V Kul'chavenya, S Yu Shevchenko, E V Brizhatyuk
INTRODUCTION: Chronic prostatitis is a prevalent urologic disease, but treatment outcomes are not always satisfactory. As a rule, chronic prostatitis results in chronic pelvic pain syndrome, significantly reducing the patient's quality of life. MATERIAL AND METHODS: Open pilot prospective non-comparative study was conducted to test the effectiveness of extracorporeal shock wave therapy (ESWT) using Aries (Dornier) machine in patients with chronic prostatitis (CP) of IIIb category...
April 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28247509/the-age-dependent-association-between-aortic-pulse-wave-velocity-and-telomere-length
#19
Barry J McDonnell, Yasmin, Lee Butcher, John R Cockcroft, Ian B Wilkinson, Jorge D Erusalimsky, Carmel M McEniery
KEY POINTS: Age significantly modifies the relationship between aortic pulse wave velocity and telomere length. The differential relationships observed between aortic pulse wave velocity and telomere length in younger and older individuals suggest that the links between cellular and vascular ageing reflect a complex interaction between genetic and environmental factors acting over the life-course. ABSTRACT: Ageing is associated with marked large artery stiffening...
March 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28235961/distributions-of-subclinical-cardiovascular-disease-in-a-socioeconomically-and-racially-diverse-sample
#20
Carrington R Wendell, Shari R Waldstein, Michele K Evans, Alan B Zonderman
BACKGROUND AND PURPOSE: Differential subgroup vulnerability to subclinical cardiovascular disease is likely, and yet few, if any, studies have addressed interactive relations of age, sex, race, and socioeconomic status (SES) to these conditions to examine nuances of known health disparities. We examined distributions of carotid atherosclerosis and arterial stiffness in a socioeconomically diverse, biracial, urban sample. METHODS: Participants (n=2270) in the population-based HANDLS study (Healthy Aging in Neighborhoods of Diversity Across the Life Span; 30-64 years old, 44% men, 57% African American, 39% with household income <125% federal poverty threshold) underwent carotid intimal medial thickness (IMT) and pulse wave velocity assessment...
February 24, 2017: Stroke; a Journal of Cerebral Circulation
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