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https://www.readbyqxmd.com/read/28728487/feasibility-and-characteristics-of-arterial-stiffness-measurement-in-preschool-children
#1
Maaike M Vanderschuren, Cuno Spm Uiterwaal, Cornelis K van der Ent, Jacobien B Eising
Background Arterial stiffness is an important predictor of cardiovascular risk in adult life. Increased arterial stiffness can also be present in children and may be associated with several other cardiovascular risk factors. Until now, however, we know little about measuring arterial stiffness in preschool children. In this study, we assessed the feasibility of measuring arterial stiffness in preschool children and explored possible determinants related to arterial stiffness at this age. Methods We studied 168 healthy children, aged 3...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28724951/n-terminal-pro-brain-natriuretic-peptide-and-associated-factors-in-the-general-working-population-a-baseline-survey-of-the-uranosaki-cohort-study
#2
Atsushi Tanaka, Hisako Yoshida, Atsushi Kawaguchi, Jun-Ichi Oyama, Norihiko Kotooka, Shigeru Toyoda, Teruo Inoue, Masafumi Natsuaki, Koichi Node
Few data on clinical characteristics associated with N-terminal pro-brain natriuretic peptide (NT-proBNP) or the clinical value of measuring NT-proBNP in the working population are available. The aim of the present study was to investigate the levels of NT-proBNP and their association with clinical variables in the Japanese general working population by using baseline data from the Uranosaki cohort study. In the study, the plasma concentration of NT-proBNP and some biomarkers were measured in addition to the standard health checkups at the workplace...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724647/physiological-responses-to-fluctuating-temperatures-are-characterized-by-distinct-transcriptional-profiles-in-a-solitary-bee
#3
Alex S Torson, George D Yocum, Joseph P Rinehart, Sean A Nash, Kally M Kvidera, Julia H Bowsher
Exposure to stressful low temperatures during development can result in the accumulation of deleterious physiological effects called chill injury. Metabolic imbalances, disruptions in ion homeostasis, and oxidative stress contribute to the increased mortality of chill-injured insects. Interestingly, survival can be significantly increased when chill susceptible insects are exposed to a daily warm-temperature pulse during chilling. We hypothesize that warm pulses allow for the repair of damage associated with chill-injury...
July 19, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28724570/childhood-thyroid-function-body-composition-and-cardiovascular-function
#4
Mirjana Barjaktarovic, Tim Korevaar, Romy Gaillard, Yolanda B de Rijke, Theo J Visser, Vincent Wv Jaddoe, Robin P Peeters
OBJECTIVE: The cardiovascular system is a known target for thyroid hormone. Early-life cardiovascular alterations may lead to a higher risk of cardiovascular disease in adulthood. Little is known about the effects of thyroid hormone on cardiovascular function during childhood, including the role of body composition in this association. DESIGN: Population-based prospective cohort of children (N=4251, median age 6 years, 95% range 5.7-8.0 years). METHODS: Thyroid stimulating hormone (TSH) and free thyroxine (FT4) concentrations were measured to assess thyroid function...
July 19, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28715367/microfluidic-imaging-flow-cytometry-by-asymmetric-detection-time-stretch-optical-microscopy-atom
#5
Anson H L Tang, Queenie T K Lai, Bob M F Chung, Kelvin C M Lee, Aaron T Y Mok, G K Yip, Anderson H C Shum, Kenneth K Y Wong, Kevin K Tsia
Scaling the number of measurable parameters, which allows for multidimensional data analysis and thus higher-confidence statistical results, has been the main trend in the advanced development of flow cytometry. Notably, adding high-resolution imaging capabilities allows for the complex morphological analysis of cellular/sub-cellular structures. This is not possible with standard flow cytometers. However, it is valuable for advancing our knowledge of cellular functions and can benefit life science research, clinical diagnostics, and environmental monitoring...
June 28, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28714674/characterization-of-chemical-exchange-using-relaxation-dispersion-of-hyperpolarized-nuclear-spins
#6
Mengxiao Liu, Yaewon Kim, Christian Hilty
Chemical exchange phenomena are ubiquitous in macromolecules, which undergo conformational change or ligand complexation. NMR relaxation dispersion (RD) spectroscopy based on a Carr-Purcell-Meiboom-Gill pulse sequence is widely applied to identify the exchange and measure the life time of intermediate states on the millisecond time scale. Advances in hyperpolarization methods improve the applicability of NMR spectroscopy when rapid acquisitions or low concentrations are required, through an increase in signal strength by several orders of magnitude...
July 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28706991/multiplexed-gene-control-reveals-rapid-mrna-turnover
#7
Antoine Baudrimont, Sylvia Voegeli, Eduardo Calero Viloria, Fabian Stritt, Marine Lenon, Takeo Wada, Vincent Jaquet, Attila Becskei
The rates of mRNA synthesis and decay determine the mRNA expression level. The two processes are under coordinated control, which makes the measurements of these rates challenging, as evidenced by the low correlation among the methods of measurement of RNA half-lives. We developed a minimally invasive method, multiplexed gene control, to shut off expression of genes with controllable synthetic promoters. The method was validated by measuring the ratios of the nascent to mature mRNA molecules and by measuring the half-life with endogenous promoters that can be controlled naturally or through inserting short sequences that impart repressibility...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28706325/axsis-exploring-the-frontiers-in-attosecond-x-ray-science-imaging-and-spectroscopy
#8
F X Kärtner, F Ahr, A-L Calendron, H Çankaya, S Carbajo, G Chang, G Cirmi, K Dörner, U Dorda, A Fallahi, A Hartin, M Hemmer, R Hobbs, Y Hua, W R Huang, R Letrun, N Matlis, V Mazalova, O D Mücke, E Nanni, W Putnam, K Ravi, F Reichert, I Sarrou, X Wu, A Yahaghi, H Ye, L Zapata, D Zhang, C Zhou, R J D Miller, K K Berggren, H Graafsma, A Meents, R W Assmann, H N Chapman, P Fromme
X-ray crystallography is one of the main methods to determine atomic-resolution 3D images of the whole spectrum of molecules ranging from small inorganic clusters to large protein complexes consisting of hundred-thousands of atoms that constitute the macromolecular machinery of life. Life is not static, and unravelling the structure and dynamics of the most important reactions in chemistry and biology is essential to uncover their mechanism. Many of these reactions, including photosynthesis which drives our biosphere, are light induced and occur on ultrafast timescales...
September 1, 2016: Nuclear Instruments & Methods in Physics Research. Section A, Accelerators, Spectrometers, Detectors and Associated Equipment
https://www.readbyqxmd.com/read/28702986/electromagnetic-field-in-control-tissue-regeneration-pelvic-pain-neuro-inflammation-and-modulation-of-non-neuronal-cells
#9
S E Aragona, G Mereghetti, G Gianazza, A Salsa, G Gianazza, J Lotti, A Vosa, T Lotti, E Canavesi
In scientific literature, magnetic fields are used both in basic science and clinical research. They are often used to treat pain and neuro-inflammation disorders thanks to their influence on cellular responses. Our project was born from the regenerative support that we wanted to give to those diseases characterized by neuro-inflammation, nerve lesion, muscles and tissues disorders that can transform the symptom (e.g. neuropathic pelvic pain) in disease. In this study, we examined the action of pulsed electromagnetic fields (PEMFs) on skin lesion regeneration and the repetitive trans-pelvic magnetic stimulation (rTPMS) on patients affected by incontinence and post-surgical problems, sexual dysfunction, and pelvic pain...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28700090/dietary-practices-and-fodmaps-in-south-asia-applicability-of-the-low-fodmap-diet-to-patients-with-irritable-bowel-syndrome
#10
REVIEW
Samapriya P Hewawasam, Marina Iacovou, Jane G Muir, Peter R Gibson
The low FODMAP diet has been described, evaluated and found efficacious for the treatment of patients with irritable bowel syndrome (IBS) primarily in Western countries. The aim of this review was to address the applicability of this diet to South Asia. The high prevalence of IBS in South Asia and its associated effects of quality of life and economics warrants the introduction of efficacious therapies. The considerable heterogeneity of dietary patterns and methods of food preparation across South Asian countries and a paucity of food analysis limit precision in defining foods that are high or low in FODMAPs...
July 12, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28689791/peanut-specific-tr1-cells-induced-in-vitro-from-allergic-individuals-are-functionally-impaired
#11
Laurence Pellerin, Jennifer Anne Jenks, Sharon Chinthrajah, Tina Dominguez, Whitney Block, Xiaoying Zhou, Arram Noshirvan, Silvia Gregori, Maria Grazia Roncarolo, Kari Christine Nadeau, Rosa Bacchetta
BACKGROUND: Peanut allergy is a life threatening condition which lacks regulatory-approved treatment. T regulatory type 1 (Tr1) cells are potent suppressors of immune responses and can be induced in vivo upon repeated antigen exposure or in vitro using tolerogenic dendritic cells (DC-10). Whether or not oral immunotherapy (OIT) leads to antigen-specific Tr1 cell induction has not been established. OBJECTIVES: To determine whether peanut-specific Tr1 cells can be generated in vitro from peripheral blood of peanut allergic (PA) individuals at baseline or during OIT, and whether they are functional as compared to peanut-specific Tr1 cells induced from healthy controls (HC)...
July 6, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28689102/monthly-methylprednisolone-in-combination-with-interferon-beta-or-glatiramer-acetate-for-relapsing-remitting-multiple-sclerosis-a-multicentre-single-blind-prospective-trial
#12
Serkan Ozakbas, Bilge Piri Cinar, Gorkem Kosehasanoğullari, Turhan Kahraman, Didem Oz, Behice Bircan Kursun
OBJECTIVES: Multiple sclerosis is usually clinically characterized by repeated subacute relapses followed by remissions. Corticosteroids are used for relapses, and this treatment has been shown to increase the speed of recovery from these. We aimed to evaluate the efficacy and safety of pulsed methylprednisolone given every month as an add-on therapy to interferon beta or glatiramer acetate in patients with relapsing-remitting multiple sclerosis. PATIENTS AND METHODS: This was a multi-center, examiner-blinded, prospective study...
June 27, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28675182/unilateral-atrial-fibrillation-how-common-is-atrial-divorce
#13
J Ker
Atrial fibrillation is the most common pathologic supraventricular tachycardia. It has many causes, is an expensive disease, impairs quality of life and leads to an increased risk of death. Atrial dissociation is characterised by the presence of two independent sets of P-waves. This peculiar abnormality may give rise to the scenario where one atrium is in atrial fibrillation while the other is in sinus rhythm. This is the first published case of atrial dissociation where the phenomenon is demonstrated by transmitral and transtricuspid pulsed wave Doppler...
June 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/28669372/observational-study-on-safety-of-prehospital-bls-cpap-in-dyspnea
#14
Novneet Sahu, Patrick Matthews, Kathryn Groner, Mia A Papas, Ross Megargel
Introduction Continuous positive airway pressure (CPAP) improves outcomes in patients with respiratory distress. Additional benefits are seen with CPAP application in the prehospital setting. Theoretical safety concerns regarding Basic Life Support (BLS) providers using CPAP exist. In Delaware's (USA) two-tiered Emergency Medical Service (EMS) system, BLS often arrives before Advanced Life Support (ALS). Hypothesis This study fills a gap in literature by evaluating the safety of CPAP applied by BLS prior to ALS arrival...
July 3, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28665162/the-effect-of-pulsed-dye-laser-on-cutaneous-leishmaniasis-and-its-impact-on-the-dermatology-life-quality-index
#15
Mohamed L Elsaie, Shady M Ibrahim
BACKGROUND AND OBJECTIVE: Cutaneous leishmaniasis is a skin condition of prevalence especially in the Middle Eastern region. The Pulsed dye laser (PDL) has not been thoroughly evaluated for treatment of cutaneous leishmaniasis (CL). We assessed primarily the efficacy of 595nm PDL in the treatment of CL lesions and interpreted its impact on the quality of life of affected patients as measured by the Dermatology Life Quality Index (DLQI). PATIENTS AND METHODS: 25 lesions from 12 patients were treated with a single pass of PDL over the whole lesions to develop a purpuric end point...
June 30, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28661960/longitudinal-study-of-the-influence-of-lung-function-on-vascular-health-from-adolescence-to-early-adulthood-in-a-british-multiethnic-cohort
#16
Yao Lu, Lum Sooky, Maria João Silva, Oarabile R Molaodi, Alexis Karamanos, J Kennedy Cruickshank, Seeromanie Harding
BACKGROUND: Vascular and lung function develop and decline over the life course; both predict cardiovascular events and mortality but little is known of how they develop over time. We analysed their relationship in a multiethnic cohort study to test whether lung function from early adolescence to young adulthood affected vascular indices. METHODS: 'DASH' (http://dash.sphsu.mrc.ac.uk) included 6643 children aged 11-13 years in 2003; a representative 10% sample (n = 665) participated in a pilot follow-up in 2013...
July 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28660556/the-effect-of-endothelin-receptor-antagonists-in-patients-with-eisenmenger-syndrome-a-systematic-review
#17
REVIEW
Abdelrahman Elshafay, Duy Hieu Truong, Mohamed M AboElnas, Hossam Idrees, Hatem G Metwali, Nguyen Lam Vuong, Omar Ahmed Saad, Kenji Hirayama, Nguyen Tien Huy
INTRODUCTION: The efficacy of endothelin receptor antagonists (ERAs) in the management of Eisenmenger syndrome (ES) remains controversial. The aim of this study is to systemically review the safety and effects of ERAs in improving the quality of life and basic cardiac functions of these patients. METHODS: Twelve databases were searched, including PubMed, Web of Science, Scopus, Virtual Health Library, World Health Organization (WHO) Global Health Library, Google Scholar, POPLINE, Systems for Information of Grey Literature in Europe, New York Academy of Medicine, ClinicalTrials...
June 28, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/28649470/determinants-of-seasonal-changes-in-availability-of-food-patches-for-elephants-loxodonta-africana-in-a-semi-arid-african-savanna
#18
Bruce W Clegg, Timothy G O'Connor
Loss of biodiversity caused by impact of elephants (Loxodonta africana) on African woodlands may require a management response, but any action should be based on an understanding of why elephants choose to utilise trees destructively. Comprehension of elephant feeding behaviour requires consideration of the relative value of the plant groups they may potentially consume. Profitability of available food is partly determined by the time to locate a food patch and, therefore, as a foundation for understanding the influence of food availability on diet selection, key controls on the density of grass, forb, and browse patches were investigated across space and time in a semi-arid African savanna...
2017: PeerJ
https://www.readbyqxmd.com/read/28649329/food-availability-as-a-major-driver-in-the-evolution-of-life-history-strategies-of-sibling-species
#19
Raphaël Arlettaz, Philippe Christe, Michael Schaub
Life-history theory predicts trade-offs between reproductive and survival traits such that different strategies or environmental constraints may yield comparable lifetime reproductive success among conspecifics. Food availability is one of the most important environmental factors shaping developmental processes. It notably affects key life-history components such as reproduction and survival prospect. We investigated whether food resource availability could also operate as an ultimate driver of life-history strategy variation between species...
June 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28648819/%C3%AE-9-tetrahydrocannabinol-%C3%AE-9-thc-administration-after-neonatal-exposure-to-phencyclidine-potentiates-schizophrenia-related-behavioral-phenotypes-in-mice
#20
Guadalupe Rodríguez, Nichole M Neugebauer, Katherine Lan Yao, Herbert Y Meltzer, John G Csernansky, Hongxin Dong
The clinical onset of schizophrenia often coincides with cannabis use in adolescents and young adults. However, the neurobiological consequences of this co-morbidity are not well understood. In this study, we examined the effects of Δ9-THC exposure during early adulthood on schizophrenia-related behaviors using a developmental mouse model of schizophrenia. Phencyclidine (PCP) or saline was administered once in neonatal mice (at P7; 10mg/kg). In turn, Δ9-THC or saline was administered sub-acutely later in life to cohorts of animals who had received either PCP or saline (P55-80, 5mg/kg)...
June 23, 2017: Pharmacology, Biochemistry, and Behavior
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