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Cholangiocarcinoma classification

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https://www.readbyqxmd.com/read/29779313/-curative-effect-analysis-of-bile-reinfusion-combined-with-enteral-nutrition-support-before-surgery-of-hilar-cholangiocarcinoma
#1
P Song, L Mao, X J Bian, T Zhou, Y Y Fan, J Zhang, M Xie, Y D Qiu
Objective: To investigate the clinical effect of bile reinfusion combined with enteral nutrition support before surgery for hilar cholangiocarcinoma. Methods: A retrospective analysis of patients with hilar cholangiocarcinoma who underwent surgical treatment at Nanjing Drum Tower Hospital Hepato-biliary-pancreatic Surgery Department from July 2010 to August 2017 was completed.A total of 52 cases were finally enrolled in our study.All the patients included, on the basis of whether they received preoperative drainage and bile reinfusion, were divided into non-drainage group( n =15) and drainage group( n =37)...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29779306/-surgical-and-comprehensive-treatment-for-intrahepatic-cholangiocarcinoma-patients-from-the-perspective-of-tumor-heterogeneity
#2
Z H Tang, Z W Quan
Intrahepatic cholangiocarcinoma(ICC) is generally found late along with extremely poor prognosis and lack of effective and standardized treatment. Tremendous heterogeneities exist in onset factors, geographic distribution, clinical manifestation, and biological characteristics of ICC patients. However, the relevant causes and mechanisms have not been clearly illustrated. Recent studies indicate that the diverse celluar origins of ICC, including liver cells, bile duct epithelial cells, glandular cells around the duct, and liver stem cells, etc...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29775791/an-imaging-biomarker-for-assessing-hepatic-function-in-patients-with-primary-sclerosing-cholangitis
#3
Jennifer Schulze, Henrike Lenzen, Jan B Hinrichs, Burckhardt Ringe, Michael P Manns, Frank Wacker, Kristina I Ringe
BACKGROUND & AIMS: We aimed to evaluate the potential of hepatobiliary phase magnetic resonance imaging (MRI) as parameter for assessment of hepatocellular function in patients with primary sclerosing cholangitis (PSC). METHODS: We collected data from 111 patients (83 male, 28 female; median, 44 years old), from March 2012 through March 2016, with a confirmed diagnosis of PSC who underwent MRI evaluation before and after injection (hepatobiliary phase) of a hepatocyte-specific contrast agent (gadoxetate disodium)...
May 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29761148/mortality-associated-with-hepatobiliary-disease-in-portugal-between-2006-and-2012
#4
Manuel Coelho da Rocha, Rui T Marinho, Teresa Rodrigues
Introduction: Hepatobiliary disease is becoming a major public health problem, and recent data suggest that the burden of liver disease is higher than previously thought. Our aim was to quantify the mortality from hepatobiliary disease in Portugal and to compare this with the mortality related o other causes over a 7-year period (2006-2012). Materials and Methods: A statistical analysis of mortality data according to cause, sex, age, and region from the National Statistics Institute in Portugal was carried out...
April 2018: GE Portuguese journal of gastroenterology
https://www.readbyqxmd.com/read/29751883/cholangiocarcinoma
#5
REVIEW
Alyssa M Krasinskas
This article focuses on cholangiocarcinoma, both intrahepatic and extrahepatic. The various classification schemes based on anatomic location, macroscopic growth pattern, microscopic features, and cell of origin are outlined. The clinicopathologic, immunohistochemical and molecular differences between intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma, as well as differences in the 2 subtypes of intrahepatic cholangiocarcinoma, are discussed. Finally, precursor lesions, prognosis, treatment, and promising new potential targeted therapies are reviewed...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29732001/prognostic-impact-of-programmed-cell-death-ligand-1-pd-l1-expression-and-its-association-with-epithelial-mesenchymal-transition-in-extrahepatic-cholangiocarcinoma
#6
Takashi Ueno, Takahiro Tsuchikawa, Kanako C Hatanaka, Yutaka Hatanaka, Tomoko Mitsuhashi, Yoshitsugu Nakanishi, Takehiro Noji, Toru Nakamura, Keisuke Okamura, Yoshihiro Matsuno, Satoshi Hirano
Extrahepatic cholangiocarcinoma (eCCA) has a poor prognosis. Although the possibility of immunotherapy has been studied, immune checkpoint molecules such as programmed death ligand 1 (PD-L1) in eCCA are not well understood. Epithelial-mesenchymal transition (EMT) has recently been shown to regulate PD-L1 expression. Our aims were to assess the clinicopathological significance of tumor-infiltrating lymphocytes (TILs) and tumor PD-L1 expression in eCCA and to compare these immune responses with EMT marker expression...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29721628/impact-of-tumor-localization-on-the-outcomes-of-surgery-for-an-intrahepatic-cholangiocarcinoma
#7
Tatsuya Orimo, Toshiya Kamiyama, Tomoko Mitsuhashi, Hirofumi Kamachi, Hideki Yokoo, Kenji Wakayama, Shingo Shimada, Akihisa Nagatsu, Akinobu Taketomi
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) shows differing clinical outcomes depending on its localization. METHODS: We reviewed the surgical outcomes of 104 ICC patients who underwent liver resection at our institution. We divided ICC into hilar type (HICC) and peripheral type (PICC) depending on positive contact with the hepatic hilum on preoperative computed tomography (CT). RESULTS: The survival outcomes were significantly poorer in HICC patients...
May 2, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29688585/reappraisal-of-classification-of-distal-cholangiocarcinoma-based-on-tumour-depth
#8
H Aoyama, T Ebata, M Hattori, M Takano, H Yamamoto, M Inoue, Y Asaba, M Ando, M Nagino
BACKGROUND: In the eighth edition of the AJCC cancer staging classification, the T system for distal cholangiocarcinoma (DCC) has been revised from a layer-based to a depth-based approach. The aim of this study was to propose an optimal T classification using a measured depth in resectable DCC. METHODS: Patients who underwent pancreatoduodenectomy for DCC at 32 hospitals between 2001 and 2010 were included. The distance between the level of the naive bile duct and the deepest cancer cells was measured as depth of invasion (DOI)...
April 24, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29675965/il-33-overexpression-reflects-less-aggressive-tumour-features-in-large-duct-type-cholangiocarcinomas
#9
Ryuichiro Sawada, Yuna Ku, Masayuki Akita, Kyoko Otani, Kohei Fujikura, Tomoo Itoh, Tetsuo Ajiki, Takumi Fukumoto, Yoshihiro Kakeji, Yoh Zen
BACKGROUND & AIMS: The present study aimed to elucidate the clinicopathological significance of IL-6 and IL-33 expression in intrahepatic cholangiocarcinomas (iCCAs) and perihilar cholangiocarcinomas (pCCAs). METHODS: IL-6 and IL-33 mRNA expression was examined in iCCAs (n=55) and pCCAs (n=32) using quantitative real-time PCR and a highly sensitive in situ hybridization protocol (RNAscope® ), and expression values were correlated with clinicopathological features...
April 19, 2018: Histopathology
https://www.readbyqxmd.com/read/29627334/preoperative-risk-score-to-predict-occult-metastatic-or-locally-advanced-disease-in-patients-with-resectable-perihilar-cholangiocarcinoma-on-imaging
#10
Jimme K Wiggers, Bas Groot Koerkamp, David van Klaveren, Robert J Coelen, C Yung Nio, Peter J Allen, Marc G Besselink, Olivier R Busch, Michael I D'Angelica, Ronald P DeMatteo, T Peter Kingham, Thomas M van Gulik, William R Jarnagin
BACKGROUND: Many patients with resectable perihilar cholangiocarcinoma (PHC) on imaging are intra-operatively diagnosed with occult metastatic or locally advanced disease precluding a curative-intent resection. This study aimed to develop and validate a preoperative risk score. STUDY DESIGN: Patients with resectable PHC on imaging who underwent surgery in two high-volume centers (USA and Europe) between 2000 and 2015 were included. Multivariable logistic regression analysis was used to develop the risk score...
April 5, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29573451/dataset-for-the-reporting-of-intrahepatic-cholangiocarcinoma-perihilar-cholangiocarcinoma-and-hepatocellular-carcinoma-recommendations-from-the-international-collaboration-on-cancer-reporting-iccr
#11
REVIEW
Alastair D Burt, Venâncio Alves, Pierre Bedossa, Andrew D Clouston, Maria Guido, Stefan G Hübscher, Sanjay Kakar, Irene O Ng, Young Nyun Park, Helen L Reeves, Judith Wyatt, Matthew M Yeh, David W Ellis
Optimal patient management benefits from comprehensive and accurate pathology reports that contribute to cancer staging and prognostication. In many countries, proforma reports are used but these vary in their structure and implementation. The International Collaboration on Cancer Reporting (ICCR) is an alliance formed by the Royal College of Pathologists of Australasia, the Royal College of Pathologists of the United Kingdom, the College of American Pathologists, the Canadian Partnership Against Cancer the European Society of Pathology, and the American Society of Clinical Pathology (ASCP) with the aim of developing an evidence-based reporting data set for each cancer site...
March 24, 2018: Histopathology
https://www.readbyqxmd.com/read/29552225/expression-levels-of-serum-mirna-195-in-different-types-of-patients-with-cholangiocarcinoma-and-its-value-to-determine-the-prognosis-thereof
#12
Qingliang Chen, Congmei Wang, Hongkai Zhang, Yun Li, Yunhong Cao, Yongxiang Zhang, Shaokun Liu, Zhen Li, Xiaoguo Xin, Xinwei Han
This study aimed to investigate the expression levels of microRNA-195 (miRNA-195) in different types of patients with cholangiocarcinoma (CCA) and its correlation with the prognosis. Serum samples were collected from different types of patients with CCA (I, II, III, IV) and normal cases, followed by detection of expression of miRNA-195 using quantitative polymerase chain reaction (qPCR). The serum samples of 204 patients with CCA, including 75 cases of type I, 68 cases of type II, 35 cases of type III and 26 cases of type IV and 200 healthy subjects were selected...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29545843/application-of-3d-visualization-and-3d-printing-technology-on-ercp-for-patients-with-hilar-cholangiocarcinoma
#13
Yan Yang, Zhongyin Zhou, Rong Liu, Lu Chen, Hongyu Xiang, Na Chen
Endoscopic retrograde cholangiopancreatography (ERCP) is an important treatment for inoperable hilar cholangiocarcinoma (HCC). The aim of the present study as to evaluate the clinical value of three-dimensional visualization (3DV) and 3D printing (3DP) technologies for ERCP in patients with HCC. The clinical data of 15 patients with HCC admitted for ERCP were analyzed retrospectively, including 9 males and 6 females. Thin-sliced data of computed tomography and magnetic resonance cholangiopancreatography (MRCP) were acquired and imported into Mimics Innovation Suite v17...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29512000/evaluation-of-the-ajcc-8th-edition-staging-system-for-pathologically-versus-clinically-staged-intrahepatic-cholangiocarcinoma-icca-a-time-to-revisit-a-dogma-a-surveillance-epidemiology-and-end-results-seer-analysis
#14
Sivesh K Kamarajah
BACKGROUND: Recently, the AJCC has released its 8th edition changes to the staging system for intrahepatic cholangiocarcinoma (iCCA). This study sought to validate the proposed changes to the 8th edition of AJCC system for T and N classification of iCCA using a population-based data set. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) database (1998-2013), patients undergoing resection or non-surgical management for non-metastatic iCCA were identified...
March 7, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29467557/esophageal-metastasis-of-stem-cell-subtype-hepatocholangiocarcinoma-rare-presentation-of-a-rare-tumor
#15
Maëva Salimon, Nicolas Chapelle, Tamara Matysiak-Budnik, Jean-François Mosnier, Eric Frampas, Yann Touchefeu
Hepatocholangiocarcinoma (cHCC-ICC) is a rare primary hepatic tumor defined by the presence of histological features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Its prevalence ranges from 1%-5% of all primary liver cancers. We report the case of a 55-year-old cirrhotic male patient admitted to our university hospital for dysphagia, revealing a 10 cm lower-third esophageal metastasis of an unresectable cHCC-ICC with stem-cell features. Computed tomography and abdominal magnetic resonance imaging scans revealed multiple hepatic lesions combining features of both HCC and ICC, associated with synchronous bone metastasis...
February 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29387397/impact-of-the-histological-phenotype-of-extrahepatic-bile-duct-carcinoma
#16
Kensuke Okano, Tadashi Yoshizawa, Takuya Miura, Keinosuke Ishido, Daisuke Kudo, Norihisa Kimura, Tai-Ichi Wakiya, Yunyan Wu, Satoko Morohashi, Kenichi Hakamada, Hiroshi Kijima
The classification of histological phenotypes was originally conceived for pancreatic intraductal papillary mucinous neoplasms. Recently, it has been introduced for extrahepatic cholangiocarcinoma. The aim of the present study was to clarify the associations between histological phenotype and clinicopathological features of extrahepatic cholangiocarcinoma, using 99 cases of surgically-resected extrahepatic cholangiocarcinoma. All cases were divided into one of two histological phenotypes: Biliary-type (BT; 56 cases, 56...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29360550/genomic-characterization-of-biliary-tract-cancers-identifies-driver-genes-and-predisposing-mutations
#17
Christopher P Wardell, Masashi Fujita, Toru Yamada, Michele Simbolo, Matteo Fassan, Rosa Karlic, Paz Polak, Jaegil Kim, Yutaka Hatanaka, Kazuhiro Maejima, Rita T Lawlor, Yoshitsugu Nakanishi, Tomoko Mitsuhashi, Akihiro Fujimoto, Mayuko Furuta, Andrea Ruzzenente, Simone Conci, Ayako Oosawa, Aya Sasaki-Oku, Kaoru Nakano, Hiroko Tanaka, Yujiro Yamamoto, Kubo Michiaki, Yoshiiku Kawakami, Hiroshi Aikata, Masaki Ueno, Shinya Hayami, Kunihito Gotoh, Shun-Ichi Ariizumi, Masakazu Yamamoto, Hiroki Yamaue, Kazuaki Chayama, Satoru Miyano, Gad Getz, Aldo Scarpa, Satoshi Hirano, Toru Nakamura, Hidewaki Nakagawa
BACKGROUND & AIMS: Biliary tract cancers (BTCs) are clinically and pathologically heterogeneous and respond poorly to treatment. Genomic profiling can offer a clearer understanding of their carcinogenesis, classification and treatment strategy. We performed large-scale genome sequencing analyses on BTCs to investigate their somatic and germline driver events and characterize their genomic landscape. METHODS: We analyzed 412 BTC samples from Japanese and Italian populations, 107 by whole-exome sequencing (WES), 39 by whole-genome sequencing (WGS), and a further 266 samples by targeted sequencing...
May 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29350570/benefits-of-laparoscopic-approach-for-resection-of-liver-tumors-in-cirrhotic-patients
#18
Fabien Le Roux, Lionel Rebibo, Cyril Cosse, Denis Chatelain, Eric Nguyen-Khac, Rachid Badaoui, Jean-Marc Regimbeau
INTRODUCTION: Liver resection in cirrhotic patients is associated with increased morbidity and mortality. The objective of this study was to compare short-term results of laparoscopic resection (LR) and open surgery (OS) for minor liver resection in patients with hepatocellular carcinoma (HCC) hepatocellularcarcinoma on nontumor cirrhotic liver (HCC/F4) and patients with colorectal cancer liver metastases (CRLMs) colorectal liver metastases on healthy liver (CRLM/F0). MATERIALS AND METHODS: Between January 2005 and December 2014, all patients undergoing liver resection (n = 754) were included in this study...
January 19, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29350068/primary-liver-cancers-part-1-histopathology-differential-diagnoses-and-risk-stratification
#19
Kun Jiang, Sameer Al-Diffhala, Barbara A Centeno
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the 2 most common primary malignant liver tumors, with hepatocellular and bile ductular differentiation, respectively. This article reviews the key histopathological findings of these 2 primary liver cancers and includes a review of the role of ancillary testing for differential diagnosis, risk stratification according to the American Joint Committee on Cancer (AJCC) staging recommendation, and a review of precancerous lesions. A literature review was conducted to identify articles with information relevant to precancerous precursors, current histopathological classification, ancillary testing, and risk stratification of primary malignant liver tumors...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29313399/localized-intrahepatic-igg4-related-sclerosing-cholangitis-igg4-sc-as-an-additional-type-of-igg4-sc-a-systematic-analysis-of-12-cases
#20
Zhichao Mo, Kuvaneshan Ramen, Yunfeng Shan, Mengtao Zhou, Xiangwu Zheng, Xiuling Wu, Zhengping Yu, Xiaoke Ji, Qiyu Zhang, Qiqiang Zeng
OBJECTIVES: IgG4-related sclerosing cholangitis (IgG4-SC), a recently defined disease entity, has been classified into four types based on the stricture regions revealed by cholangiography. However, localized intrahepatic IgG4-SC is not included into the classification. This study aimed to analyze and characterize localized intrahepatic IgG4-SC and justify the inclusion of this type into the classification. METHODS: PubMed and Embase were searched for studies published from March 2001 to June 2017 reporting localized intrahepatic IgG4-SC...
March 2018: Scandinavian Journal of Gastroenterology
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