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Cholangiocarcinoma classification

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https://www.readbyqxmd.com/read/29350570/benefits-of-laparoscopic-approach-for-resection-of-liver-tumors-in-cirrhotic-patients
#1
Fabien Le Roux, Lionel Rebibo, Cyril Cosse, Denis Chatelain, Eric Nguyen-Khac, Rachid Badaoui, Jean-Marc Regimbeau
INTRODUCTION: Liver resection in cirrhotic patients is associated with increased morbidity and mortality. The objective of this study was to compare short-term results of laparoscopic resection (LR) and open surgery (OS) for minor liver resection in patients with hepatocellular carcinoma (HCC) hepatocellularcarcinoma on nontumor cirrhotic liver (HCC/F4) and patients with colorectal cancer liver metastases (CRLMs) colorectal liver metastases on healthy liver (CRLM/F0). MATERIALS AND METHODS: Between January 2005 and December 2014, all patients undergoing liver resection (n = 754) were included in this study...
January 19, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29350068/primary-liver-cancers-part-1-histopathology-differential-diagnoses-and-risk-stratification
#2
Kun Jiang, Sameer Al-Diffhala, Barbara A Centeno
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the 2 most common primary malignant liver tumors, with hepatocellular and bile ductular differentiation, respectively. This article reviews the key histopathological findings of these 2 primary liver cancers and includes a review of the role of ancillary testing for differential diagnosis, risk stratification according to the American Joint Committee on Cancer (AJCC) staging recommendation, and a review of precancerous lesions. A literature review was conducted to identify articles with information relevant to precancerous precursors, current histopathological classification, ancillary testing, and risk stratification of primary malignant liver tumors...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29313399/localized-intrahepatic-igg4-related-sclerosing-cholangitis-igg4-sc-as-an-additional-type-of-igg4-sc-a-systematic-analysis-of-12-cases
#3
Zhichao Mo, Kuvaneshan Ramen, Yunfeng Shan, Mengtao Zhou, Xiangwu Zheng, Xiuling Wu, Zhengping Yu, Xiaoke Ji, Qiyu Zhang, Qiqiang Zeng
OBJECTIVES: IgG4-related sclerosing cholangitis (IgG4-SC), a recently defined disease entity, has been classified into four types based on the stricture regions revealed by cholangiography. However, localized intrahepatic IgG4-SC is not included into the classification. This study aimed to analyze and characterize localized intrahepatic IgG4-SC and justify the inclusion of this type into the classification. METHODS: PubMed and Embase were searched for studies published from March 2001 to June 2017 reporting localized intrahepatic IgG4-SC...
January 9, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29285229/relationship-of-tumor-size-with-pathological-and-prognostic-factors-for-hilar-cholangiocarcinoma
#4
Hai-Jie Hu, Rong-Xing Zhou, Anuj Shrestha, Yong-Qiong Tan, Wen-Jie Ma, Qin Yang, Jiong Lu, Jun-Ke Wang, Yong Zhou, Fu-Yu Li
Objective: To determine the correlation of different tumor-size cutoffs with prognostic factors and survival outcomes to provide a reference for the modification of the T-stage classification in the DeOliveira staging system for hilar cholangiocarcinoma (HCCA). Materials and Methods: We retrospectively analyzed 216 patients who underwent curative surgery for HCCA (mean tumor diameter, 2.8 cm) between 2000 and 2013. Univariate and multivariate logistic regression were used to assess the correlation of tumor-size cutoffs with various factors...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29274841/preoperative-risk-score-and-prediction-of-long-term-outcomes-after-hepatectomy-for-intrahepatic-cholangiocarcinoma
#5
Kazunari Sasaki, Georgios A Margonis, Nikolaos Andreatos, Fabio Bagante, Matthew Weiss, Carlotta Barbon, Irinel Popescu, Hugo P Marques, Luca Aldrighetti, Shishir K Maithel, Carlo Pulitano, Todd W Bauer, Feng Shen, George A Poultsides, Oliver Soubrane, Guillaume Martel, B Groot Koerkamp, Alfredo Guglielmi, Endo Itaru, Federico N Aucejo, Timothy M Pawlik
BACKGROUND: Accurate prediction of prognosis for patients with intrahepatic cholangiocarcinoma(ICC) remains a challenge. We sought to define a preoperative risk tool to predict long-term survival following resection of ICC. METHODS: Patients who underwent hepatectomy for ICC at one of 16 major hepatobilliary centers between 1990-2015 were identified. Clinico-pathological data were analyzed and a prognostic model was developed based on the regression beta-coefficients on data in training set...
December 21, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29156495/multicenter-study-of-endoscopic-preoperative-biliary-drainage-for-malignant-hilar-biliary-obstruction-e-pod-hilar-study
#6
Yousuke Nakai, Ryuichi Yamamoto, Masato Matsuyama, Yuji Sakai, Yukiko Takayama, Jun Ushio, Yukiko Ito, Katsuya Kitamura, Shomei Ryozawa, Tsunao Imamura, Kouhei Tsuchida, Jo Hayama, Takao Itoi, Yoshiaki Kawaguchi, Yu Yoshida, Kazuya Sugimori, Kenji Shimura, Masafumi Mizuide, Tomohisa Iwai, Ko Nishikawa, Hiroshi Yagioka, Masatsugu Nagahama, Nobuo Toda, Tomotaka Saito, Ichiro Yasuda, Kenji Hirano, Osamu Togawa, Kenji Nakamura, Iruru Maetani, Naoki Sasahira, Hiroyuki Isayama
BACKGROUND AND AIM: Endoscopic nasobiliary drainage (ENBD) is often recommended in preoperative biliary drainage (PBD) for hilar malignant biliary obstruction (MBO) but endoscopic biliary stent (EBS) is also used in the clinical practice. We conducted this large scale multicenter study to compare ENBD and EBS in this setting. METHODS: A total of 374 cases undergoing PBD including 281 ENBD and 76 EBS for hilar MBO in 29 centers were retrospectively studied. RESULTS: Extrahepatic cholangiocarcinoma (ECC) accounted for 69...
November 20, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29119290/a-proposed-severity-classification-system-for-hepatolithiasis-based-on-an-analysis-of-prognostic-factors-in-a-japanese-patient-cohort
#7
Yutaka Suzuki, Toshiyuki Mori, Masaaki Yokoyama, Sangchul Kim, Hirokazu Momose, Ryota Matsuki, Masaharu Kogure, Nobutsugu Abe, Hiroyuki Isayama, Takahiro Nakazawa, Kenji Notohara, Atsushi Tanaka, Toshio Tsuyuguchi, Susumu Tazuma, Hajime Takikawa, Masanori Sugiyama
BACKGROUND: Hepatolithiasis frequently results in severe complications. We conducted a cohort study to identify prognostic factors and to establish a hepatolithiasis severity classification system. METHODS: The study cohort comprised 396 patients who were identified through a 1998 nationwide survey and followed up for 18 years or until death. Cox regression analysis was used to identify prognostic factors. RESULTS: Median survival time of the patients was 308 (range 0-462) months...
November 8, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29063951/-biliary-tract-cancers-molecular-characterization-and-identification-of-novel-prognostic-markers
#8
REVIEW
B Goeppert
BACKGROUND: Bile duct cancers (BTCs) are highly aggressive tumors with a dismal prognosis and an increasing incidence. BTC is a tumorbiologically and clinically heterogeneous tumor group and can be subdivided according to anatomical aspects into intrahepatic cholangiocarcinomas (iCCA), extrahepatic cholangiocarcinomas (eCCA) and gallbladder carcinomas (GBC). NEW THERAPY OPTIONS: Chronic inflammatory processes of the biliary system seem to play a role in the development of these tumors...
October 24, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29039079/a-long-term-survivor-of-hilar-cholangiocarcinoma-with-resection-of-recurrent-peritoneal-dissemination-after-r0-surgery-a-case-report
#9
Tatsunori Miyata, Hirohisa Okabe, Akira Chikamoto, Takanobu Yamao, Naoki Umezaki, Masayo Tsukamoto, Yuki Kitano, Kota Arima, Shigeki Nakagawa, Katsunori Imai, Daisuke Hashimoto, Yo-Ichi Yamashita, Hideo Baba
BACKGROUND: Although hilar cholangiocarcinoma (HCCA) has a very poor prognosis, there are cases in which long-term survival is rarely obtained by multidisciplinary treatment. CASE PRESENTATION: A 61-year-old man diagnosed with HCCA was referred to our hospital. We performed an extended left hemi-hepatectomy and caudate lobectomy with extrahepatic bile duct resection. The tumor stage was T2aN0M0, stage II, based on the TNM classification, seventh edition. R0 resection was successfully performed...
October 16, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28958483/the-prognostic-value-of-portal-vein-and-hepatic-artery-involvement-in-patients-with-perihilar-cholangiocarcinoma
#10
Jeroen L A van Vugt, Marcia P Gaspersz, Robert J S Coelen, Jaynee Vugts, Tim A Labeur, Jeroen de Jonge, Wojciech G Polak, Olivier R C Busch, Marc G Besselink, Jan N M IJzermans, Chung Y Nio, Thomas M van Gulik, François E J A Willemssen, Bas Groot Koerkamp
BACKGROUND: Although several classifications of perihilar cholangiocarcinoma (PHC) include vascular involvement, its prognostic value has not been investigated. Our aim was to assess the prognostic value of unilateral and main/bilateral involvement of the portal vein (PV) and hepatic artery (HA) on imaging in patients with PHC. METHODS: All patients with PHC between 2002 and 2014 were included regardless of stage or management. Vascular involvement was defined as apparent tumor contact of at least 180° to the PV or HA on imaging...
September 25, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28952140/identification-of-patients-for-adjuvant-therapy-after-resection-of-carcinoma-of-the-extrahepatic-bile-ducts-a-propensity-score-matched-analysis
#11
Brett L Ecker, Charles C Vining, Robert E Roses, Laura Maggino, Major K Lee, Jeffrey A Drebin, Douglas L Fraker, Charles M Vollmer, Jashodeep Datta
BACKGROUND: Resectability rates for extrahepatic cholangiocarcinoma have increased over time, but long-term survival after resection alone with curative intent remains poor. Recent series suggest improved survival with adjuvant therapy. Patient subsets benefiting most from adjuvant therapy have not been clearly defined. METHODS: Patients with extrahepatic cholangiocarcinoma who underwent resection with curative intent and received adjuvant therapy (chemotherapy ± radiotherapy) or surgery alone (SA) were identified in the U...
September 26, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28890312/clinicopathological-features-and-prognosis-of-advanced-biliary-carcinoma-centered-in-the-cystic-duct
#12
Yoshitsugu Nakanishi, Takahiro Tsuchikawa, Keisuke Okamura, Toru Nakamura, Takehiro Noji, Toshimichi Asano, Kimitaka Tanaka, Toshiaki Shichinohe, Tomoko Mitsuhashi, Satoshi Hirano
BACKGROUND: Whether to classify "advanced (subserosal layer or greater invasion)" biliary carcinoma centered in the cystic duct (BCCD) as gallbladder carcinoma (GBC) or perihilar cholangiocarcinoma (PHCC) remains unclear. METHODS: The clinicopathological features and overall survival (OS) of patients with advanced BCCD were examined through a comparison with those of patients with advanced PHCC and with GBC. RESULTS: 290 patients were classified as 199 PHCC, 44 GBC, and 47 BCCD...
September 7, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28887635/the-prognostic-impact-of-controlling-nutritional-status-conut-in-intrahepatic-cholangiocarcinoma-following-curative-hepatectomy-a-retrospective-single-institution-study
#13
Tatsunori Miyata, Yo-Ichi Yamashita, Takaaki Higashi, Katsunobu Taki, Daisuke Izumi, Keisuke Kosumi, Ryuma Tokunaga, Shigeki Nakagawa, Hirohisa Okabe, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Hideo Baba
BACKGROUND: Several studies have examined controlling nutritional status (CONUT), which is one of the useful biomarkers for predicting patients' prognosis following cancer treatment. The aim of this study was to evaluate the value of CONUT as a postoperative prognostic marker in patients with intrahepatic cholangiocarcinoma (ICC) following curative hepatectomy. METHODS: We retrospectively analyzed 71 patients who underwent curative hepatectomy for ICC between May 2002 and November 2016...
September 8, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28834905/modified-staging-classification-for-intrahepatic-cholangiocarcinoma-based-on-the-sixth-and-seventh-editions-of-the-ajcc-uicc-tnm-staging-systems
#14
Ze-Wu Meng, Wei Pan, Hai-Jie Hong, Jiang-Zhi Chen, Yan-Ling Chen
Intrahepatic cholangiocarcinoma (ICC) was differentiated from hepatocellular carcinoma, as defined in the American Joint Committee on Cancer (AJCC) 6th edition staging manual, using the revised staging system described in the AJCC 7th edition staging manual. This study was conducted to analyze the application of the AJCC 6th and 7th edition staging classifications and to evaluate a modified staging classification to potentially reduce the limitations associated with the different AJCC staging systems.We compared the prognostic value of cancer staging using data from the Surveillance, Epidemiology, and End Results database (N = 2124)...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28782798/pancreatoduodenectomy-with-portal-vein-resection-for-distal-cholangiocarcinoma
#15
T Maeta, T Ebata, E Hayashi, T Kawahara, S Mizuno, N Matsumoto, S Ohta, M Nagino
BACKGROUND: Little is known about the value of portal vein (PV) resection in distal cholangiocarcinoma. The aim of this study was to evaluate the clinical significance of PV resection in distal cholangiocarcinoma. METHODS: Patients who underwent pancreatoduodenectomy (PD) for distal cholangiocarcinoma between 2001 and 2010 at one of 31 hospitals in Japan were reviewed retrospectively with special attention to PV resection. Short- and long-term outcomes were evaluated...
October 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28712319/primary-liver-cancer-genome-sequencing-translational-implications-and-challenges
#16
Demosthenes E Ziogas, Ioannis D Kyrochristos, Georgios K Glantzounis, Dimitrios Christodoulou, Evangelos Felekouras, Dimitrios H Roukos
The prognosis of primary liver cancer (PLC) remains poor and is explained by the slow progress in understanding the molecular pathways driving tumorigenesis, therapeutic resistance and relapse. For early PLCs, complete surgical resection is the only effective treatment, with sorafenib and, more recently, regorafenib prolonging overall survival by a few months. Areas covered: Application of next-generation sequencing (NGS), including targeted NGS (tNGS), whole-exome sequencing (WES), whole-genome sequencing (WGS) and RNA sequencing (RNAseq), on clinical samples from patients with hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) could aid in comprehending tumorigenesis, genetic and genomic heterogeneity, as well as developing molecular classifications for specialized targeted therapy...
July 26, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28675365/extension-of-hepatic-resection-ameliorates-survival-in-patients-with-type-iiia-or-iiib-klatskin-tumors-despite-surgical-complications
#17
Radu Razvan Scurtu, George Dindelegan, Vasile Bintintan, Radu Drasovean, Raluca Apostu, Constantin Ciuce
Background: Major hepatectomies for hilar cholangiocarcinoma (HC) are associated with high rates of morbidity and mortality. We aimed to evaluate how and if surgical complications related to extended hepatectomies for HC type III and IV according to Bismuth-Corlette classification influence patients long-term survival. Methods: The files of all patients with major hepatectomy for HC and postoperative complications were retrospectively reviewed. Only patients with a complete postoperative follow up have be taken into account for the study...
May 2017: Chirurgia
https://www.readbyqxmd.com/read/28624005/differentiation-between-cholangiocarcinoma-and-hepatocellular-carcinoma-with-target-sign-on-diffusion-weighted-imaging-and-hepatobiliary-phase-gadoxetic-acid-enhanced-mr-imaging-classification-tree-analysis-applying-capsule-and-septum
#18
Ji Hye Min, Young Kon Kim, Seo-Youn Choi, Woo Kyoung Jeong, Won Jae Lee, Sang Yun Ha, Soohyun Ahn, Hyeon Seon Ahn
OBJECTIVES: To assess the usefulness of classification tree analysis (CTA) for discrimination of hepatocellular carcinoma (HCC) with target sign on hepatobiliary phase (HBP) and/or diffusion-weighted image (DWI) from intrahepatic cholangiocarcinoma (ICC). METHODS: This retrospective study was approved by the institutional review board. From among the 811 patients with histopathologically proven 79 ICCs and 732 HCCs, 69 patients with 69 (87.3%) ICCs and 115 patients with 115 HCCs (15...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28577720/multidisciplinary-management-of-intrahepatic-cholangiocarcinoma-current-approaches
#19
REVIEW
Hanisah Guro, Jin Won Kim, YoungRok Choi, Jai Young Cho, Yoo-Seok Yoon, Ho-Seong Han
Intrahepatic cholangiocarcinoma (ICC) is a common primary hepatic tumor. However, its outcomes are usually worse than those of hepatocellular carcinoma owing to its non-specific presentation and detection at an advanced stage. The most widely used serum marker, carbohydrate antigen 19-9, is non-specific. Furthermore, imaging studies rarely identify any pathognomonic features. Surgery is the only treatment option that offers a chance of long-term survival. However, the resectability rate is low owing to the high frequencies of intrahepatic metastases, peritoneal carcinomatosis, or extrahepatic metastases...
June 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28573638/peribiliary-liver-metastases-mr-findings
#20
Vincenza Granata, Roberta Fusco, Orlando Catalano, Antonio Avallone, Maddalena Leongito, Francesco Izzo, Antonella Petrillo
We described magnetic resonance (MR) features of peribiliary metastasis and of periductal infiltrative cholangiocarcinoma. We assessed 35 patients, with peribiliary lesions, using MR 4-point confidence scale. T1-weighted (T1-W), T2-weighted (T2-W) and diffusion-weighted images (DWI) signal intensity, enhancement pattern during arterial, portal, equilibrium and hepatobiliary phase were assessed. We identified 24 patients with periductal-infiltrating cholangiocellular carcinoma. The lesions in 34 patients appeared as a single tissue, while in a single patient, the lesions appeared as multiple individual lesions...
July 2017: Medical Oncology
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