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Cholangiocarcinoma classification

Kyoung-Bun Lee
A bile duct lesion originating from intrahepatic bile ducts is generally regarded as an incidental pathologic finding in liver specimens. However, a recent study on the molecular classification of intrahepatic cholangiocarcinoma has focused on the heterogeneity of this carcinoma and has suggested that the cells of different origins present in the biliary tree may have a major role in the mechanism of oncogenesis. In this review, benign intrahepatic bile duct lesions-regarded in the past as reactive changes or remnant developmental anomalies and now noted to have potential for developing precursor lesions of intrahepatic cholangiocarcinoma-are discussed by focusing on the histopathologic features and its implications in clinical practice...
September 2016: Clinical and Molecular Hepatology
Lei Yuan, Xianwu Luo, Xinyuan Lu, Bin Huang, Quanyu Cai
Intrahepatic cholangiocarcinoma (ICC) is usually confirmed in advanced stage at the time of diagnosis or after surgical exploration, however, indication of surgical treatment is usually controversial for ICC in advanced stages. This retrospective study aims to evaluate clinical value of surgery for such tumors, in order to identify the appropriate patients who will benefit from surgery, and to evaluate the prognostic accuracy of the current staging system for advanced ICC. From January 2007 to December 2011, 387 consecutive surgically treated patients with ICC in AJCC‑stage Ⅳ were evaluated...
September 19, 2016: Oncology Reports
Tomoki Ebata, Takashi Mizuno, Masato Nagino
No abstract text is available yet for this article.
September 2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
N Zeng, C H Fang, Y F Fan, J Yang, N Xiang, W Zhu, J Liu, W Cai, Z K Mo
OBJECTIVE: To explore the construction and clinical efficacy of three-dimensional(3D) visualization platform about diagnosis and treatment of hilar cholangiocarcinoma. METHODS: From January 2009 to December 2015, a total of 32 patients with hilarcholangiocarcinoma treated in Zhujiang Hospital of Southern Medical University were analyzed.There were 20 male and 12 female patients aged from 40 to 85 years. Bismuth-Corlette 3D visualization type: 2 cases with type Ⅰ, 5 cases with type Ⅱ, 10 cases with type Ⅲa, 11 cases with type Ⅲb, 4 cases with type Ⅳ...
September 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Yukio Oshiro, Ryozo Gen, Shinji Hashimoto, Tatsuya Oda, Taiki Sato, Nobuhiro Ohkohchi
Neuroendocrine carcinoma (NEC) originating from the gastrointestinal hepatobiliary-pancreas is a rare, invasive, and progressive disease, for which the prognosis is extremely poor. The patient was a 72-year-old man referred with complaints of jaundice. He was diagnosed with middle extrahepatic cholangiocarcinoma (cT4N1M0, cStage IV). He underwent a right hepatectomy combined with extrahepatic bile duct and portal vein resection after percutaneous transhepatic portal vein embolization. Microscopic examination showed a large-cell neuroendocrine carcinoma according to the WHO criteria for the clinicopathologic classification of gastroenteropancreatic neuroendocrine tumors...
August 14, 2016: World Journal of Gastroenterology: WJG
Kyueng-Whan Min, Dong-Hoon Kim, Byoung Kwan Son, Eun-Kyung Kim, Sang Bong Ahn, Seong Hwan Kim, Yun Ju Jo, Young Sook Park, Jinwon Seo, Young Ha Oh, Sukjoong Oh, Ho Young Kim, Mi Jung Kwon, Soo Kee Min, Hye-Rim Park, Ji-Young Choe, Jang Yong Jeon, Hong Il Ha, Jung Woo Lee
BACKGROUND: AJCC staging system is unreliable for predicting survival in distal bile duct (DBD) cancer patients, due to inter-observer variation. Measured depth of invasion (DOI) is suggested to be more accurate to predict patients' clinical outcome in extra-hepatic cholangiocarcinomas, but its significance in DBD cancer and cutoff values are still debatable. This study aimed to identify the optimal cutoff value of DOI in relation to prognosis in DBD cancer patients. METHODS: Data of 179 patients with DBD adenocarcinoma treated in three institutions were investigated...
August 22, 2016: World Journal of Surgery
Lauren M Postlewait, Cecilia G Ethun, Nina Le, Timothy M Pawlik, Stefan Buettner, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Bradley Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza Beal, Ioannis Hatzaras, Gerardo Vitiello, Kenneth Cardona, Shishir K Maithel
BACKGROUND: Seventh AJCC distal cholangiocarcinoma T-stage classification inadequately separates patients by survival. This retrospective study aimed to define a novel T-stage system to better stratify patients after resection. METHODS: Curative-intent pancreaticoduodenectomies for distal cholangiocarcinoma (1/2000-5/2015) at 10 US institutions were included. Relationships between tumor characteristics and overall survival (OS) were assessed and incorporated into a novel T-stage classification...
October 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
T O Babatunde, J O Ogunbiyi
BACKGROUND: Biliary tract carcinomas are uncommon but highly fatal malignancies. Most patients in our environment are diagnosed late and are not candidates for curative resection. OBJECTIVE: To determine the pattern and risk factors of biliary tract carcinoma in Ibadan. METHODOLOGY: This was a retrospective study of histologically confirmed cases of biliary tract carcinoma diagnosed at the University College Hospital, Ibadan between January 1971 and December 20 10...
December 2015: African Journal of Medicine and Medical Sciences
Kohei Fujikura, Takumi Fukumoto, Tetsuo Ajiki, Kyoko Otani, Maki Kanzawa, Masayuki Akita, Masahiro Kido, Yonson Ku, Tomoo Itoh, Yoh Zen
AIMS: This study was aimed to achieve a better definition of intraductal papillary neoplasms of the bile duct (IPNBs). METHODS AND RESULTS: Biliary tumours that showed predominantly intraductal papillary growth were provisionally classified into IPNBs (n=25) and papillary cholangiocarcinomas (n=27). IPNB was defined as a neoplasm that is confined to the epithelium or is regularly arranged in a high-papillary architecture along thin fibrovascular stalks, while the term "papillary cholangiocarcinoma" was used for tumours with more complex papillary structures (e...
July 13, 2016: Histopathology
Alexandre Doussot, Mithat Gonen, Jimme K Wiggers, Bas Groot-Koerkamp, Ronald P DeMatteo, David Fuks, Peter J Allen, Olivier Farges, T Peter Kingham, Jean Marc Regimbeau, Michael I D'Angelica, Daniel Azoulay, William R Jarnagin
BACKGROUND: Liver resection is the most effective treatment for intrahepatic cholangiocarcinoma. Recurrent disease is frequent; however, recurrence patterns are ill-defined and prognostic models are lacking. STUDY DESIGN: A primary cohort of 189 patients who underwent resection for intrahepatic cholangiocarcinoma was used for recurrence patterns analysis within and after 24 months. Based on independent factors for disease-free survival identified in Cox regression analysis, preoperative and postoperative models were developed using a recursive partitioning method...
September 2016: Journal of the American College of Surgeons
Akimasa Hayashi, Kento Misumi, Junji Shibahara, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Masashi Fukayama
Previous studies have identified 2 clinically significant morphologic subtypes of intrahepatic cholangiocarcinoma (ICC) on the basis of anatomic location and/or histologic appearances. Recognizing that these classification schemes are not always applicable practically, this study aimed to establish a novel classification system based on mucin productivity and immunophenotype and to determine the rationale of this classification by examining the clinicopathologic and genetic characteristics of the 2 subtypes defined by this method...
August 2016: American Journal of Surgical Pathology
Takehiro Noji, Takahiro Tsuchikawa, Keisuke Okamura, Kimitaka Tanaka, Yoshitsugu Nakanishi, Toshimichi Asano, Toru Nakamura, Toshiaki Shichinohe, Satoshi Hirano
BACKGROUND: Whether concomitant hepatic artery resection (HAR) improves the prognosis for advanced perihilar cholangiocarcinoma remains controversial. The aim of the present study was to compare short- and long-term surgical results of HAR versus standard resection (SR) for perihilar cholangiocarcinoma using propensity score matching. METHODS: Among 209 patients with perihilar cholangiocarcinoma patients who underwent resection in our department, 28 patients underwent HAR, and the remaining 181 patients underwent SR...
July 2016: Journal of Hepato-biliary-pancreatic Sciences
Seesai Yeesoonsang, Surichi Beenheem, Edward McNeil, Sophon Iamsirithaworn, Chuleeporn Jiraphongsa, Hutcha Sriplung
Purpose: Histological specimens are not required for diagnosis of liver and bile duct (LBD) cancer, resulting in a high percentage of unknown histologies. We compared estimates of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) incidences by imputing these unknown histologies. Materials and Methods: A retrospective study was conducted using data from the Songkhla cancer registry, southern Thailand, from 1989 to 2013. Multivariate imputation by chained equations (mice) was used in re-classification of the unknown histologies...
May 18, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Siham Ait Oussous, Saïd Boujraf, Imane Kamaoui
The goal is assessing the diffusion magnetic resonance imaging (dMRI) method efficiency in characterizing focal hepatic lesions (FHLs). About 28-FHL patients were studied in Radiology and Clinical Imaging Department of our University Hospital using 1.5 Tesla MRI system between January 2010 and June 2011. Patients underwent hepatic MRI consisting of dynamic T1- and T2-weighted imaging. The dMRI was performed with b-values of 200 s/mm(2) and 600 s/mm(2). About 42 lesions measuring more than 1 cm were studied including the variation of the signal according to the b-value and the apparent diffusion coefficient (ADC)...
April 2016: Journal of Medical Signals and Sensors
An-Qiang Wang, Yong-Chang Zheng, Juan Du, Cheng-Pei Zhu, Han-Chun Huang, Shan-Shan Wang, Liang-Cai Wu, Xue-Shuai Wan, Hao-Hai Zhang, Ruo-Yu Miao, Xin-Ting Sang, Hai-Tao Zhao
Combined hepatocellular cholangiocarcinoma (CHC) accounts for 0.4%-14.2% of primary liver cancer cases and possesses pathological features of both hepatocellular carcinoma and cholangiocarcinoma. Since this disease was first described and classified in 1949, the classification of CHC has continuously evolved. The latest definition and classification of CHC by the World Health Organization is based on the speculation that CHC arises from hepatic progenitor cells. However, there is no evidence demonstrating the common origin of different components of CHC...
May 14, 2016: World Journal of Gastroenterology: WJG
Robert J Lewandowski, Larry Donahue, Attasit Chokechanachaisakul, Laura Kulik, Samdeep Mouli, Juan Caicedo, Michael Abecassis, Jonathan Fryer, Riad Salem, Talia Baker
BACKGROUND: The purpose of this study is to assess operative, post-operative, and long-term outcomes in patients who underwent radiation lobectomy (RL) for tumor control and/or hypertrophy of small future liver remnant (FLR) prior to resection. METHODS: Right lobar +/- segment 4 radioembolization was performed prior to lobectomy/tri-segmentectomy in patients with hepatic tumor but inadequate FLR. Parenchymal/tumor volumes were calculated from pre/post-RL imaging; FLR/%FLR hypertrophy were determined...
July 2016: Journal of Surgical Oncology
Jesus M Banales, Vincenzo Cardinale, Guido Carpino, Marco Marzioni, Jesper B Andersen, Pietro Invernizzi, Guro E Lind, Trine Folseraas, Stuart J Forbes, Laura Fouassier, Andreas Geier, Diego F Calvisi, Joachim C Mertens, Michael Trauner, Antonio Benedetti, Luca Maroni, Javier Vaquero, Rocio I R Macias, Chiara Raggi, Maria J Perugorria, Eugenio Gaudio, Kirsten M Boberg, Jose J G Marin, Domenico Alvaro
Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of biliary tract differentiation. CCA is the second most common primary liver tumour and the incidence is increasing worldwide. CCA has high mortality owing to its aggressiveness, late diagnosis and refractory nature. In May 2015, the "European Network for the Study of Cholangiocarcinoma" (ENS-CCA: or was created to promote and boost international research collaboration on the study of CCA at basic, translational and clinical level...
May 2016: Nature Reviews. Gastroenterology & Hepatology
Supriya K Saha, Andrew X Zhu, Charles S Fuchs, Gabriel A Brooks
BACKGROUND: Challenges in the diagnosis and classification of cholangiocarcinoma have made it difficult to quantify the true incidence of this highly aggressive malignancy. METHODS: We analyzed the Surveillance, Epidemiology, and End Results data to assess long-term trends in the age-standardized incidence of intrahepatic and extrahepatic cholangiocarcinoma between 1973 and 2012, correcting for systematic coding errors. Because intrahepatic cholangiocarcinoma (ICC) may frequently be misdiagnosed as cancer of unknown primary (CUP), we also analyzed trends in the incidence of CUP...
May 2016: Oncologist
Molin Wongwattanakul, Chariya Hahnvajanawong, Patcharaporn Tippayawat, Sirinart Chio-Srichan, Chanvit Leelayuwat, Temduang Limpaiboon, Patcharee Jearanaikoon, Philip Heraud
Cholangiocarcinoma (CCA), a cancer of bile duct epithelium, is a major health problem in Thailand especially in the northeast. Overall treatment outcomes have not shown much improvement because the disease is usually detected at an advanced stage and often shows chemotherapeutic resistance. High-throughput Fourier Transform Infrared (FTIR) microspectroscopy can be used for cell classification and has the potential to diagnose cancer and possibly predict chemo-response. This study was aimed to differentiate gemcitabine-sensitive and gemcitabine-resistant induction in two CCA cell lines (KKU-M139 and KKU-M214) and xenograft tissues using synchrotron-FTIR microspectroscopy...
March 21, 2016: Journal of Biophotonics
Jun Akiba, Osamu Nakashima, Satoshi Hattori, Yoshiki Naito, Hironori Kusano, Reiichiro Kondo, Masamichi Nakayama, Ken Tanikawa, Keita Todoroki, Yumi Umeno, Ken Nakamura, Sakiko Sanada, Rin Yamaguchi, Sachiko Ogasawara, Hirohisa Yano
AIMS: The WHO classification describes that combined hepatocellular-cholangiocarcinoma, subtypes with stem-cell features, intermediate-cell subtype (CHC-INT) is composed of tumour cells with features intermediate between hepatocytes and cholangiocytes. However, we previously reported that CHC-INT showed a high positive rate of biliary markers, but the expression of hepatocyte paraffin (HepPar)-1 was low. In this study, we examined the expression of other hepatocyte markers, such as arginase-1 (Arg-1), keratin (K) 8 and K18 in CHC-INT in order to examine the utility of pathological diagnosis in CHC-INT...
October 2016: Journal of Clinical Pathology
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