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Cholangiocarcinoma classification

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https://www.readbyqxmd.com/read/27896409/post-resection-prognosis-of-combined-hepatocellular-carcinoma-cholangiocarcinoma-according-to-the-2010-who-classification
#1
Dong-Hwan Jung, Shin Hwang, Seung-Mo Hong, Yong-Kyu Chung, Gi-Won Song, Young-Joo Lee, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gil-Chun Park, Han Chu Lee, Young-Suk Lim, Eun Sil Yu, Sung-Gyu Lee
BACKGROUND: Combined hepatocellular carcinoma and cholangiocarcinoma (cHC) has wide histological diversity. We intended to investigate the prognostic influence of tumor types of cHC. METHODS: We analyzed the clinical and pathological features of cHC along 2010 WHO classification. Study group was 100 cHC patients who underwent primary resection. Control group comprised 200 propensity score-matched patients with intrahepatic cholangiocarcinoma (ICC). RESULTS: In cHC group, tumor diameter was 4...
November 28, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27875000/combined-hepatocellular-cholangiocarcinoma-gadoxetic-acid-enhanced-mri-findings-correlated-with-pathologic-features-and-prognosis
#2
So Hyun Park, Seung Soo Lee, Eunsil Yu, Hyo Jeong Kang, Yangsoon Park, So Yeon Kim, So Jung Lee, Yong Moon Shin, Moon Gyu Lee
PURPOSE: To evaluate gadoxetic acid-enhanced magnetic resonance imaging (MRI) findings of combined hepatocellular cholangiocarcinoma (cHCC-CC) with special emphasis on correlation of MRI findings with histopathologic tumor characteristics and survival outcomes after curative surgery. MATERIALS AND METHODS: Our Institutional Review Board approved this study, with a waiver of informed consent. For 82 patients (64 men, 18 women; mean age, 54.0 years; age range, 30-81) with surgically confirmed cHCC-CCs, we evaluated clinical features, histologic findings, and tumor morphologic and enhancement features on gadoxetic acid-enhanced liver MRI at 1...
November 22, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27829047/immunohistochemical-typing-of-adenocarcinomas-of-the-pancreatobiliary-system-improves-diagnosis-and-prognostic-stratification
#3
Carlos Fernández Moro, Alejandro Fernandez-Woodbridge, Melroy Alistair D'souza, Qianni Zhang, Benedek Bozoky, Senthil Vasan Kandaswamy, Piera Catalano, Rainer Heuchel, Sonia Shtembari, Marco Del Chiaro, Olof Danielsson, Mikael Björnstedt, J Matthias Löhr, Bengt Isaksson, Caroline Verbeke, Béla Bozóky
BACKGROUND & AIMS: Adenocarcinomas of the pancreatobiliary system are currently classified by their primary anatomical location. In particular, the pathological diagnosis of intrahepatic cholangiocarcinoma is still considered as a diagnosis of exclusion of metastatic adenocarcinoma. Periampullary cancers have been previously classified according to the histological type of differentiation (pancreatobiliary, intestinal), but overlapping morphological features hinder their differential diagnosis...
2016: PloS One
https://www.readbyqxmd.com/read/27795812/mucins-in-neoplasms-of-pancreas-ampulla-of-vater-and-biliary-system
#4
REVIEW
Dimitrios Moschovis, Giorgos Bamias, Ioanna Delladetsima
Tumors of the pancreas, the ampulla of Vater, and the extrahepatic and intrahepatic bile ducts have significant histological similarities due to the common embryonic origin of the pancreatobiliary system. This obviates the need for discovery of biomarkers with diagnostic and prognostic value for these tumors. Mucins, especially MUC-1, -2, -4 and -5AC, are important candidates for developing into such reliable biomarkers. Increased expression of MUC1 occurs in pancreatic ductal adenocarcinomas and is associated with increased degrees of dysplasia in pancreatic intraepithelial neoplasia (PanIN)...
October 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27787479/biliary-fistula-after-liver-resection-central-role-of-intra-operative-perihepatic-drain
#5
Matteo Barabino, Andrea Gatti, Roberto Santambrogio, Leonardo Centonze, Matteo Virdis, Maria R Angiolini, Carmelo Luigiano, Enrico Opocher
BACKGROUND: Despite notable advances in surgical skills and technology, incidence of biliary fistula after hepatic resection remains an issue. Aim of this study is to assess the role of intra-operative perihepatic drain in diagnosis and treatment of this complication. METHODS: The study included 641 patients who underwent hepatic resection without hepaticojejunostomy between Jan-2003 and Jan-2016. Data were obtained from our single- institution perspective database...
October 27, 2016: Minerva Chirurgica
https://www.readbyqxmd.com/read/27729636/histopathology-of-a-benign-bile-duct-lesion-in-the-liver-morphologic-mimicker-or-precursor-of-intrahepatic-cholangiocarcinoma
#6
Kyoung-Bun Lee
A bile duct lesion originating from intrahepatic bile ducts is generally regarded as an incidental pathologic finding in liver specimens. However, a recent study on the molecular classification of intrahepatic cholangiocarcinoma has focused on the heterogeneity of this carcinoma and has suggested that the cells of different origins present in the biliary tree may have a major role in the mechanism of oncogenesis. In this review, benign intrahepatic bile duct lesions-regarded in the past as reactive changes or remnant developmental anomalies and now noted to have potential for developing precursor lesions of intrahepatic cholangiocarcinoma-are discussed by focusing on the histopathologic features and its implications in clinical practice...
September 2016: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/27666632/liver-resection-for-intrahepatic-cholangiocarcinoma-in-ajcc%C3%A2-stage-%C3%A2-an%C3%A2-evaluation-of-the-survival-benefit-and-prognostic-accuracy-of-current-ajcc-staging-system-on-n-and-m-classification
#7
Lei Yuan, Xianwu Luo, Xinyuan Lu, Bin Huang, Quanyu Cai
Intrahepatic cholangiocarcinoma (ICC) is usually confirmed in advanced stage at the time of diagnosis or after surgical exploration, however, indication of surgical treatment is usually controversial for ICC in advanced stages. This retrospective study aims to evaluate clinical value of surgery for such tumors, in order to identify the appropriate patients who will benefit from surgery, and to evaluate the prognostic accuracy of the current staging system for advanced ICC. From January 2007 to December 2011, 387 consecutive surgically treated patients with ICC in AJCC‑stage Ⅳ were evaluated...
September 19, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27593361/current-topic-of-interest-classification-of-intrahepatic-and-hilar-cholangiocarcinomas
#8
Tomoki Ebata, Takashi Mizuno, Masato Nagino
No abstract text is available yet for this article.
September 2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27587211/-the-construction-of-three-dimensional-visualization-platform-and-its-application-in-diagnosis-and-treatment-for-hilar-cholangiocarcinoma
#9
N Zeng, C H Fang, Y F Fan, J Yang, N Xiang, W Zhu, J Liu, W Cai, Z K Mo
OBJECTIVE: To explore the construction and clinical efficacy of three-dimensional(3D) visualization platform about diagnosis and treatment of hilar cholangiocarcinoma. METHODS: From January 2009 to December 2015, a total of 32 patients with hilarcholangiocarcinoma treated in Zhujiang Hospital of Southern Medical University were analyzed.There were 20 male and 12 female patients aged from 40 to 85 years. Bismuth-Corlette 3D visualization type: 2 cases with type Ⅰ, 5 cases with type Ⅱ, 10 cases with type Ⅲa, 11 cases with type Ⅲb, 4 cases with type Ⅳ...
September 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27570432/neuroendocrine-carcinoma-of-the-extrahepatic-bile-duct-a-case-report
#10
Yukio Oshiro, Ryozo Gen, Shinji Hashimoto, Tatsuya Oda, Taiki Sato, Nobuhiro Ohkohchi
Neuroendocrine carcinoma (NEC) originating from the gastrointestinal hepatobiliary-pancreas is a rare, invasive, and progressive disease, for which the prognosis is extremely poor. The patient was a 72-year-old man referred with complaints of jaundice. He was diagnosed with middle extrahepatic cholangiocarcinoma (cT4N1M0, cStage IV). He underwent a right hepatectomy combined with extrahepatic bile duct and portal vein resection after percutaneous transhepatic portal vein embolization. Microscopic examination showed a large-cell neuroendocrine carcinoma according to the WHO criteria for the clinicopathologic classification of gastroenteropancreatic neuroendocrine tumors...
August 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27549598/invasion-depth-measured-in-millimeters-is-a-predictor-of-survival-in-patients-with-distal-bile-duct-cancer-decision-tree-approach
#11
Kyueng-Whan Min, Dong-Hoon Kim, Byoung Kwan Son, Eun-Kyung Kim, Sang Bong Ahn, Seong Hwan Kim, Yun Ju Jo, Young Sook Park, Jinwon Seo, Young Ha Oh, Sukjoong Oh, Ho Young Kim, Mi Jung Kwon, Soo Kee Min, Hye-Rim Park, Ji-Young Choe, Jang Yong Jeon, Hong Il Ha, Jung Woo Lee
BACKGROUND: AJCC staging system is unreliable for predicting survival in distal bile duct (DBD) cancer patients, due to inter-observer variation. Measured depth of invasion (DOI) is suggested to be more accurate to predict patients' clinical outcome in extra-hepatic cholangiocarcinomas, but its significance in DBD cancer and cutoff values are still debatable. This study aimed to identify the optimal cutoff value of DOI in relation to prognosis in DBD cancer patients. METHODS: Data of 179 patients with DBD adenocarcinoma treated in three institutions were investigated...
August 22, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27506989/proposal-for-a-new-t-stage-classification-system-for-distal-cholangiocarcinoma-a-10-institution-study-from-the-u-s-extrahepatic-biliary-malignancy-consortium
#12
Lauren M Postlewait, Cecilia G Ethun, Nina Le, Timothy M Pawlik, Stefan Buettner, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Bradley Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza Beal, Ioannis Hatzaras, Gerardo Vitiello, Kenneth Cardona, Shishir K Maithel
BACKGROUND: Seventh AJCC distal cholangiocarcinoma T-stage classification inadequately separates patients by survival. This retrospective study aimed to define a novel T-stage system to better stratify patients after resection. METHODS: Curative-intent pancreaticoduodenectomies for distal cholangiocarcinoma (1/2000-5/2015) at 10 US institutions were included. Relationships between tumor characteristics and overall survival (OS) were assessed and incorporated into a novel T-stage classification...
October 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27462695/pattern-of-biliary-tract-carcinoma-at-the-university-college-hospital-ibadan
#13
T O Babatunde, J O Ogunbiyi
BACKGROUND: Biliary tract carcinomas are uncommon but highly fatal malignancies. Most patients in our environment are diagnosed late and are not candidates for curative resection. OBJECTIVE: To determine the pattern and risk factors of biliary tract carcinoma in Ibadan. METHODOLOGY: This was a retrospective study of histologically confirmed cases of biliary tract carcinoma diagnosed at the University College Hospital, Ibadan between January 1971 and December 20 10...
December 2015: African Journal of Medicine and Medical Sciences
https://www.readbyqxmd.com/read/27410028/comparative-clinicopathological-study-of-biliary-intraductal-papillary-neoplasms-and-papillary-cholangiocarcinomas
#14
Kohei Fujikura, Takumi Fukumoto, Tetsuo Ajiki, Kyoko Otani, Maki Kanzawa, Masayuki Akita, Masahiro Kido, Yonson Ku, Tomoo Itoh, Yoh Zen
AIMS: The aim of this study was to achieve a better definition of intraductal papillary neoplasms of the bile duct (IPNBs). METHODS AND RESULTS: Biliary tumours that showed predominantly intraductal papillary growth were provisionally classified as IPNBs (n = 25) and papillary cholangiocarcinomas (n = 27). IPNB was defined as a neoplasm that is confined to the epithelium or is regularly arranged in a high-papillary architecture along thin fibrovascular stalks, whereas the term 'papillary cholangiocarcinoma' was used for tumours with more complex papillary structures (e...
July 13, 2016: Histopathology
https://www.readbyqxmd.com/read/27296525/recurrence-patterns-and-disease-free-survival-after-resection-of-intrahepatic-cholangiocarcinoma-preoperative-and-postoperative-prognostic-models
#15
Alexandre Doussot, Mithat Gonen, Jimme K Wiggers, Bas Groot-Koerkamp, Ronald P DeMatteo, David Fuks, Peter J Allen, Olivier Farges, T Peter Kingham, Jean Marc Regimbeau, Michael I D'Angelica, Daniel Azoulay, William R Jarnagin
BACKGROUND: Liver resection is the most effective treatment for intrahepatic cholangiocarcinoma. Recurrent disease is frequent; however, recurrence patterns are ill-defined and prognostic models are lacking. STUDY DESIGN: A primary cohort of 189 patients who underwent resection for intrahepatic cholangiocarcinoma was used for recurrence patterns analysis within and after 24 months. Based on independent factors for disease-free survival identified in Cox regression analysis, preoperative and postoperative models were developed using a recursive partitioning method...
September 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27259014/distinct-clinicopathologic-and-genetic-features-of-2-histologic-subtypes-of-intrahepatic-cholangiocarcinoma
#16
Akimasa Hayashi, Kento Misumi, Junji Shibahara, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Masashi Fukayama
Previous studies have identified 2 clinically significant morphologic subtypes of intrahepatic cholangiocarcinoma (ICC) on the basis of anatomic location and/or histologic appearances. Recognizing that these classification schemes are not always applicable practically, this study aimed to establish a novel classification system based on mucin productivity and immunophenotype and to determine the rationale of this classification by examining the clinicopathologic and genetic characteristics of the 2 subtypes defined by this method...
August 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27207604/concomitant-hepatic-artery-resection-for-advanced-perihilar-cholangiocarcinoma-a-case-control-study-with-propensity-score-matching
#17
Takehiro Noji, Takahiro Tsuchikawa, Keisuke Okamura, Kimitaka Tanaka, Yoshitsugu Nakanishi, Toshimichi Asano, Toru Nakamura, Toshiaki Shichinohe, Satoshi Hirano
BACKGROUND: Whether concomitant hepatic artery resection (HAR) improves the prognosis for advanced perihilar cholangiocarcinoma remains controversial. The aim of the present study was to compare short- and long-term surgical results of HAR versus standard resection (SR) for perihilar cholangiocarcinoma using propensity score matching. METHODS: Among 209 patients with perihilar cholangiocarcinoma patients who underwent resection in our department, 28 patients underwent HAR, and the remaining 181 patients underwent SR...
July 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27188200/estimation-of-the-incidence-of-hepatocellular-carcinoma-and-cholangiocarcinoma-in-songkhla-thailand-1989-2013-using-multiple-imputation-method
#18
Seesai Yeesoonsang, Surichi Beenheem, Edward McNeil, Sophon Iamsirithaworn, Chuleeporn Jiraphongsa, Hutcha Sriplung
Purpose: Histological specimens are not required for diagnosis of liver and bile duct (LBD) cancer, resulting in a high percentage of unknown histologies. We compared estimates of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) incidences by imputing these unknown histologies. Materials and Methods: A retrospective study was conducted using data from the Songkhla cancer registry, southern Thailand, from 1989 to 2013. Multivariate imputation by chained equations (mice) was used in re-classification of the unknown histologies...
May 18, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27186537/assessment-of-the-focal-hepatic-lesions-using-diffusion-tensor-magnetic-resonance-imaging
#19
Siham Ait Oussous, Saïd Boujraf, Imane Kamaoui
The goal is assessing the diffusion magnetic resonance imaging (dMRI) method efficiency in characterizing focal hepatic lesions (FHLs). About 28-FHL patients were studied in Radiology and Clinical Imaging Department of our University Hospital using 1.5 Tesla MRI system between January 2010 and June 2011. Patients underwent hepatic MRI consisting of dynamic T1- and T2-weighted imaging. The dMRI was performed with b-values of 200 s/mm(2) and 600 s/mm(2). About 42 lesions measuring more than 1 cm were studied including the variation of the signal according to the b-value and the apparent diffusion coefficient (ADC)...
April 2016: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/27182157/combined-hepatocellular-cholangiocarcinoma-controversies-to-be-addressed
#20
REVIEW
An-Qiang Wang, Yong-Chang Zheng, Juan Du, Cheng-Pei Zhu, Han-Chun Huang, Shan-Shan Wang, Liang-Cai Wu, Xue-Shuai Wan, Hao-Hai Zhang, Ruo-Yu Miao, Xin-Ting Sang, Hai-Tao Zhao
Combined hepatocellular cholangiocarcinoma (CHC) accounts for 0.4%-14.2% of primary liver cancer cases and possesses pathological features of both hepatocellular carcinoma and cholangiocarcinoma. Since this disease was first described and classified in 1949, the classification of CHC has continuously evolved. The latest definition and classification of CHC by the World Health Organization is based on the speculation that CHC arises from hepatic progenitor cells. However, there is no evidence demonstrating the common origin of different components of CHC...
May 14, 2016: World Journal of Gastroenterology: WJG
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