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https://www.readbyqxmd.com/read/28218339/pattern-and-severity-of-psoriasiform-eruptions-in-patients-with-inflammatory-bowel-diseases-arthritis-or-skin-inflammatory-disorders-treated-with-tnf-alpha-inhibitors
#1
Anne-Sophie Darrigade, Brigitte Milpied, Marie-Elise Truchetet, Thierry Schaeverbeke, David Laharie, Frank Zerbib, Marie Beylot-Barry, Thomas Jouary, Alain Taïeb, Khaled Ezzedine, Julien Seneschal
Psoriasiform eruptions are a classical adverse skin reaction of tumour necrosis factor (TNF)-α inhibitors. The aim of this study was to identify the association between the severity or pattern of psoriasiform reactions and the underlying disease. A retrospective study was conducted between January 2012 and May 2015. Adult patients who developed psoriasiform eruptions whilst being treated with TNFα inhibitors were included. For each patient, 3 independent blinded dermatologists graded twice the severity of the lesions according to 6 clinical psoriasiform eruption types...
February 20, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28199343/long-term-treatment-with-abatacept-or-tocilizumab-does-not-increase-epstein-barr-virus-load-in-patients-with-rheumatoid-arthritis-a-three-years-retrospective-study
#2
Nathalie Balandraud, Gaetan Texier, Emmanuel Massy, Olivier Muis-Pistor, Marielle Martin, Isabelle Auger, Marie-Caroline Guzian, Sandrine Guis, Thao Pham, Jean Roudier
BACKGROUND: Epstein-Barr Virus (EBV) is a widely disseminated lymphotropic herpes virus implicated in benign and malignant disorders. In transplant patients, immunosuppressive drugs (cyclosporine) diminish control of EBV replication, potentially leading to lymphoproliferative disorders (LPD). Rheumatoid arthritis (RA) patients have impaired control of EBV infection and have EBV load ten times higher than controls. As post transplant patients, patients with RA have increased risk of developing lymphomas...
2017: PloS One
https://www.readbyqxmd.com/read/28193522/intracerebroventricular-injection-of-beta-amyloid-in-mice-is-associated-with-long-term-cognitive-impairment-in-the-modified-hole-board-test
#3
Sebastian Schmid, Bettina Jungwirth, Verena Gehlert, Manfred Blobner, Gerhard Schneider, Stephan Kratzer, Kristine Kellermann, Gerhard Rammes
BACKGROUND: The intracerebroventricular injection of beta-amyloid (Aβ) in mice allows the investigation of acute effects on cognitive function and cellular pathology. The aim of this investigation was to further characterize the time course of Aβ-induced cognitive and behavioural changes and to detect potential molecular mechanisms. METHODS: Cannulas were implanted in the lateral cerebral ventricle. 14days after surgery the mice were injected with Aβ1-42 or phosphate buffered saline (PBS)...
February 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28187003/tumor-necrosis-factor-alpha-is-a-promising-circulating-biomarker-for-the-development-of-obstructive-sleep-apnea-syndrome-a-meta-analysis
#4
REVIEW
Qingsheng Li, Xin Zheng
Obstructive sleep apnea syndrome (OSAS) is a chronic inflammatory disorder. The relationship between tumor necrosis factor alpha (TNF-alpha) and OSAS has been widely evaluated, but the results thus far remain inconclusive. We thereby decided to quantify the changes of TNF-alpha between OSAS patients and controls by a meta-analysis. This study complies with the MOOSE guidelines. Two reviewers independently searched articles and abstracted relevant data. In total, 47 articles (59 studies) were analyzed, including 2857 OSAS patients and 2115 controls...
February 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28186502/stat1-mediates-transmembrane-tnf-alpha-induced-formation-of-death-inducing-signaling-complex-and-apoptotic-signaling-via-tnfr1
#5
Yaping Jiang, Min Yu, Xuena Hu, Lu Han, Kun Yang, Hongping Ba, Zunyue Zhang, Bingjiao Yin, Xiang-Ping Yang, Zhuoya Li, Jing Wang
Tumor necrosis factor-alpha (TNF-α) exists in two forms: secretory TNF-α (sTNF-α) and transmembrane TNF-α (tmTNF-α). Although both forms of TNF-α induce tumor cell apoptosis, tmTNF-α is able to kill tumor cells that are resistant to sTNF-α-mediated cytotoxicity, indicating their differences in signal transduction. Here, we demonstrate that internalization of TNFR1 is crucial for sTNF-α- but not for tmTNF-α-induced apoptosis. sTNF-α induces binding of tumor necrosis factor receptor type 1-associated death domain protein (TRADD) to the death domain (DD) of TNFR1 and subsequent activation of nuclear factor kappa B (NF-κB), and the formation of death-inducing signaling complexes (DISCs) in the cytoplasm after internalization...
February 10, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28186089/adenovirus-mediated-tipe2-overexpression-inhibits-gastric-cancer-metastasis-via-reversal-of-epithelial-mesenchymal-transition
#6
H Yin, X Huang, M Tao, Q Hu, J Qiu, W Chen, J Wu, Y Xie
Tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TNFAIP8L2; also termed TIPE2) has been shown to be involved in both the immune-negative modulation and cancer. We previously found that TIPE2 is lost in human gastric cancer, and TIPE2 restoration suppresses gastric cancer growth by induction of apoptosis and impairment of protein kinase B (PKB/AKT) and extracellular signal-regulated kinase-1/2 (ERK1/2) signaling. However, its correlation with epithelial-mesenchymal transition (EMT) in gastric cancer is largely elusive...
February 10, 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28185837/insulin-promotes-her2-signaling-activation-during-barrett-s-esophagus-carcinogenesis
#7
Diletta Arcidiacono, Alessandro Antonello, Matteo Fassan, Daniele Nucci, Tiziana Morbin, Marco Agostini, Donato Nitti, Massimo Rugge, Alfredo Alberti, Giorgio Battaglia, Stefano Realdon
BACKGROUND: Insulin-resistance and hyperinsulinemia could have a role in the growing incidence of esophageal adenocarcinoma (EAC) and its pre-cancerous lesion Barrett's Esophagus (BE). HER2 activation has also a pivotal role in EAC carcinogenesis but no data correlate these two phenomena in this disease context. AIMS: To investigate the role of hyperinsulinemia in BE-dysplasia-adenocarcinoma sequence and the possible relationship between insulin-mediated and HER2 signaling in EAC development...
January 22, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28178330/comparative-study-of-extrapolative-factors-linked-with-oxidative-injury-and-anti-inflammatory-status-in-chronic-kidney-disease-patients-experiencing-cardiovascular-distress
#8
Mahmood Rasool, Muhammad Abdul Basit Ashraf, Arif Malik, Sulayman Waquar, Shahida Aziz Khan, Mahmood Husain Qazi, Waseem Ahmad, Muhammad Asif, Sami Ullah Khan, Ahmad Zaheer, Muther Mansoor Qaisrani, Abdul Rehman Khan, Aamir Iqbal, Amir Raza, Saima Iram, Kashif Kamran, Asim Iqbal, Mohammad Zahid Mustafa, Hani Choudhry, Mazin A Zamzami, Wesam H Abdulaal, Mohammad Sarwar Jamal
BACKGROUND: Chronic kidney disease (CKD) is a group of heterogeneous abnormalities affecting the function and structure of the kidney and mostly further proceeds to cardiovascular damage prior to end stage renal disease (ESRD). The oxidative insult and inflammatory mediators have some undefined role in CKD and cardiovascular complications. It is therefore, aimed at to pin point the predictive factors in the development of cardiovascular disorder in patients with chronic kidney disease...
2017: PloS One
https://www.readbyqxmd.com/read/28177743/excessive-training-is-associated-with-endoplasmic-reticulum-stress-but-not-apoptosis-in-the-hypothalamus-of-mice
#9
Ana Paula Pinto, Alisson da Rocha, Bruno Pereira, Luciana Oliveira, Gustavo Paroschi, Leandro Pereira, Eduardo Rochete Ropelle, José Rodrigo Pauli, Adelino Sanchez Ramos da Silva
Downhill running-based overtraining model increases the hypothalamic levels of IL-1beta, TNF-alpha, SOCS3 and pSAPK-JNK. The aim of the present study was to verify the effects of three overtraining protocols on the levels of BiP, pIRE-1 (Ser724), pPERK (Thr981), pelF2alpha (Ser52), ATF-6, GRP-94, caspase 4, caspase 12, pAKT (Ser473), pmTOR (Ser2448) and pAMPK (Thr172) proteins in the mouse hypothalamus. The mice were randomized into the control (CT), overtrained by downhill running (OTR/down), overtrained by uphill running (OTR/up) and overtrained by running without inclination (OTR) groups...
December 5, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28177678/protective-mechanisms-of-melatonin-against-hydrogen-peroxide-induced-toxicity-in-human-bone-marrow-derived-mesenchymal-stem-cells
#10
Saeed Mehrzadi, Majid Safa, Seyed Kamran Kamrava, Radbod Darabi, Parisa Hayat, Manijeh Motevalian
Many obstacles compromise the efficacy of bone marrow mesenchymal stem cells (MSCs) by inducing apoptosis in the grafted MSCs. Current study investigates the effect of melatonin on important mediators involved in survival of BM-MSCs in hydrogen peroxide (H2O2) apoptosis model.In brief, BM-MSCs were isolated treated with melatonin and then exposed to H2O2.Their viability was assessed by MTT assay and apoptotic fractions were evaluated through Annexin V, Hoechst staining and ADP/ATP ratio. Oxidative stress biomarkers including: ROS, total antioxidant power (TAP), superoxide dismutase (SOD) and catalase (CAT) activity, glutathione (GSH), thiol molecules and lipid peroxidation (LPO) levels were determined...
December 23, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28175113/p574-limitations-and-difficulties-in-using-anti-tnf-alpha-agents-in-inflammatory-bowel-disease-a-survey-of-the-italian-group-for-inflammatory-bowel-disease-ig-ibd
#11
S Saibeni, C Bezzio, A Armuzzi, F Bossa, E Calabrese, F Caprioli, M Daperno, F Mocciaro, A Orlando, C Papi, A Rispo, F Rizzello
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174969/p019-anti-tnf-alpha-therapy-induces-microbial-and-immunological-changes-in-dextran-sodium-sulphate-chronic-colitis
#12
V Petito, C Graziani, L Lopetuso, G Quaranta, F Paroni Sterbini, L Masucci, A Sgambato, G Cammarota, M Sanguinetti, A Gasbarrini, F Scaldaferri
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174958/p029-azelnidipine-a-novel-calcium-channel-blocker-ameliorates-severity-of-colitis-in-dss-induced-colitis-in-mice-possibly-by-modulating-tissue-levels-of-tnf-alpha-and-il-6
#13
T Kav, A Akyol, E Aksoy, C Ozer, M Torgutalp, B Sivri
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172928/p510-assessment-of-study-group-patients-with-inflammatory-bowel-disease-treated-with-monoclonal-anti-tnf-alpha-a-multicenter-prospective-cohort-observational-study-satimos-preliminary-report-in-pediatric-population
#14
D Jarzebicka, J Sieczkowska, A Borys-Iwanicka, A Korlatowicz-Bilar, A Szaflarska-Popławska, U Grzybowska-Chlebowczyk, I Łazowska-Przeorek, U Daniluk, B Korczowski, B Sordyl, M Szczepanik, P Landowski, A Plocek, K Bąk-Drabik, E Zagόrowicz, J Kierkus
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172698/p425-biosimilar-infliximab-in-real-life-crohn-s-disease-treatment-in-anti-tnf-alpha-na%C3%A3-ve-and-non-na%C3%A3-ve-patients-in-comparison-to-biologic-originator-a%C3%A2-comparative-observational-cohort-study
#15
M Kaniewska, A Moniuszko, K Maciejewska, G Rydzewska
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172692/p613-mycophenolate-mofetil-is-a-valid-option-in-patients-with-inflammatory-bowel-disease-resistant-to-tnf-alpha-inhibitors-and-conventional-immunosuppressants
#16
F S Macaluso, M Maida, S Renna, E Orlando, M Affronti, C Sapienza, M Dimarco, R Orlando, G Rizzuto, M Cottone, A Orlando
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172604/p387-the-addition-of-an-immunosuppressant-is-an-effective-optimization-strategy-after-loss-of-response-to-anti-tnf-alpha-monotherapy-in-patients-with-inflammatory-bowel-disease-a%C3%A2-two-year-experience
#17
F S Macaluso, C Sapienza, M Ventimiglia, S Renna, G Rizzuto, R Orlando, M Affronti, E Orlando, M Cottone, A Orlando
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28166688/pyrexia-s-effect-on-the-cbg-cortisol-thermocouple-rather-than-cbg-cleavage-elevates-the-acute-free-cortisol-response-to-tnf-alpha-in-humans
#18
Marni Anne Nenke, Signe Tellerup Nielsen, Louise Lang Lehrskov, John Goodwyn Lewis, Wayne Rankin, Kirsten Møller, David James Torpy
Corticosteroid-binding globulin (CBG) cleavage promotes local cortisol delivery in inflammation. Enzymatic cleavage of high-affinity CBG to low affinity CBG (haCBG to laCBG) occurs at inflammatory sites and is now measurable in vivo; however, the time kinetics of haCBG depletion following an inflammatory stimulus is unknown. Hence our aim was to determine the immediate effect of the key pro-inflammatory cytokine TNF-α on CBG levels and cleavage. We performed a crossover study of twelve healthy males receiving a TNF-α vs...
February 6, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28165828/certolizumab-pegol-for-the-treatment-of-psoriasis
#19
A Campanati, D Benfaremo, M M Luchetti, G Ganzetti, A Gabrielli, A Offidani
Psoriasis is a chronic immunomediated and inflammatory disease involving mainly skin and joints, often associated with several metabolic and non-metabolic comorbidities. TNF-alpha inhibitors have shown long-term efficacy and safety/tolerability in psoriasis, and preliminary data support the use of certolizumab pegol (CZP) as well. Areas covered: The authors review the pharmacological properties of CZP, as well as its safety data and efficacy profile. They also review the quality of life outcomes related to CZP in psoriasis...
February 6, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28161398/angiotensin-ii-induced-muscle-wasting-is-mediated-by-25-hydroxycholesterol-via-gsk3%C3%AE-signaling-pathway
#20
Congcong Shen, Jin Zhou, Xiaoxiao Wang, Xi-Yong Yu, Chun Liang, Bin Liu, Xiangbin Pan, Qiong Zhao, Jenny Lee Song, Jiajun Wang, Meiyu Bao, Chaofan Wu, Yangxin Li, Yao-Hua Song
While angiotensin II (ang II) has been implicated in the pathogenesis of cardiac cachexia (CC), the molecules that mediate ang II's wasting effect have not been identified. It is known TNF-α level is increased in patients with CC, and TNF-α release is triggered by ang II. We therefore hypothesized that ang II induced muscle wasting is mediated by TNF-α. Ang II infusion led to skeletal muscle wasting in wild type (WT) but not in TNF alpha type 1 receptor knockout (TNFR1KO) mice, suggesting that ang II induced muscle loss is mediated by TNF-α through its type 1 receptor...
January 30, 2017: EBioMedicine
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