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https://www.readbyqxmd.com/read/27936072/delonix-regia-leaf-extract-drle-a-potential-therapeutic-agent-for-cardioprotection
#1
Lung-Shuo Wang, Chun-Ting Lee, Wei-Lieh Su, Shih-Che Huang, Shu-Chi Wang
Delonix regia (Boj. Ex. Hook) is a flowering plant in the pea family found in tropical areas and its leaves are used informally to treat diseases in folk medicine. However, the cardioprotective effects in this plant are still unclear. In this study, we found that the Delonix regia leaf extract (DRLE) (400 mg/kg/d) can reduce the mortality rate in an isoproterenol (ISO)-induced heart injury and hypertrophy mouse model. Decreased serum levels of creatine phosphokinase, LDH, GOT, TNF-alpha and increased nitric oxide levels were found in DRLE-treated ISO-injured mice...
2016: PloS One
https://www.readbyqxmd.com/read/27935764/morphofunctional-renal-alterations-in-progeny-of-mice-fed-rhodiola-kirilowii-extracts-or-epigallocatechin-during-pregnancy-and-lactation
#2
Sławomir Lewicki, Ewa Skopińska-Różewska, Barbara Joanna Bałan, Bolesław Kalicki, Janusz Patera, Jacek Wilczak, Aleksander Wasiutyński, Robert Zdanowski
Treating infections in pregnant patients is potentially dangerous even when herbal medicines are used. Many herbal medicines, among them extracts from plants of Rhodiola genus, have antimicrobial, anti-inflammatory, and immunostimulatory properties owing to their polyphenol content; they may, however, affect fetal development due to their antiangiogenic properties. The aim of this study was to explain whether daily feeding pregnant and lactating mice with 20 mg/kg Rhodiola kirilowii aqueous (RKW) or 50% hydro-alcoholic (RKW-A) extracts, or 0...
December 9, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27932045/serum-and-knee-synovial-fluid-matrixmetalloproteinase-13-and-tumor-necrosis-factor-alpha-levels-in-patients-with-late-stage-osteoarthritis
#3
Kenan Özler, Erdem Aktaş, Çiğdem Atay, Barış Yılmaz, Murat Arıkan, Şafak Güngör
OBJECTIVE: To compare the levels of MMP-13 and TNF-α in late stage osteoarthritis, define their predominant pathways and investigate their correlation with McMaster Universities Arthritis Index scores. PATIENTS AND METHODS: A total of 42 patients (mean age 64 ± 8.8) with grade 3 and grade 4 knee osteoarthritis according to Kellegren- Lawrence criteria and who were scheduled for total knee arthroplasty were enrolled in the study. TNF-alpha and MMP-13 levels were measured preoperatively from venous blood samples and intraoperatively from knee synovial fluid via ELISA...
December 5, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27911957/tristetraprolin-down-regulation-contributes-to-persistent-tnf-alpha-expression-induced-by-cigarette-smoke-extract-through-a-post-transcriptional-mechanism
#4
Xue-Ke Zhao, Pulin Che, Ming-Liang Cheng, Quan Zhang, Mao Mu, Hong Li, Yuan Luo, Yue-Dong Liang, Xin-Hua Luo, Chang-Qing Gao, Patricia L Jackson, J Michael Wells, Yong Zhou, Meng Hu, Guoqiang Cai, Victor J Thannickal, Chad Steele, J Edwin Blalock, Xiaosi Han, Ching-Yi Chen, Qiang Ding
RATIONALE: Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory mediator and its expression is up-regulated in chronic obstructive pulmonary disease (COPD). Tristetraprolin (TTP) is implicated in regulation of TNF-α expression; however, whether TTP is involved in cigarette smoke-induced TNF-α expression has not been determined. METHODS: TTP expression was examined by western blot analysis in murine alveolar macrophages and alveolar epithelial cells challenged without or with cigarette smoke extract (CSE)...
2016: PloS One
https://www.readbyqxmd.com/read/27910810/production-of-tnf-alpha-ex-vivo-is-predictive-of-an-immune-response-to-flu-vaccination-in-a-frail-elderly-population
#5
Frédéric Bloch, Bénédicte Charmeteau, Michael Tovey, Jean-François Meritet, Corinne Desaint, Odile Launay, Pierre Lebon
OBJECTIVE: To investigate the relationship between the response to influenza vaccination and the ability to produce proinflamatory cytokines in elderly subjects. METHODS: Whole blood samples from 25 elderly subjects collected before influenza vaccination were stimulated with the influenza vaccine in order to evaluate the secretion of five specific cytokines: TNFα, IFNα, IFNγ, IL2 and IL10. The results were correlated with the increased HAI antibody titres two weeks after vaccination...
September 1, 2016: European Cytokine Network
https://www.readbyqxmd.com/read/27909456/serum-cytokine-levels-in-major-depressive-disorder-and-its-role-in-antidepressant-response
#6
Woojae Myung, Shinn-Won Lim, Hye In Woo, Jin Hong Park, Sanghong Shim, Soo-Youn Lee, Doh Kwan Kim
OBJECTIVE: Cytokines have been reported to have key roles in major depressive disorder (MDD). However, much less is known about cytokines in MDD and antidepressant treatment due to the diversity of cytokines and the heterogeneity of depression. We investigated the levels of cytokines in patients with MDD compared with healthy subjects and their associations with antidepressant response. METHODS: We investigated the changes of several cytokines (eotaxin, sCD40L, IL-8, MCP-1alpha, TNF-alpha, INF-gamma and MIP-1alpha) by Luminex assay in 66 patients with MDD and 22 healthy controls...
November 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27899171/the-effects-of-melatonin-and-colchicine-on-ischemia-reperfusion-injury-in-experimental-rat-testicular-torsion-model
#7
Tamer Sekmenli, Metin Gunduz, Bahadır Öztürk, Pınar Karabağlı, Ilhan Ciftci, Gülsüm Tekin, Mustafa Yılmaz
PURPOSE: The aim of the present study is to investigate the efficiency of colchicine and melatonın in an experimental rat testicular torsion model in the light of histological and biochemical data. METHODS: A total of 34 Wistar albino male rats were randomly divided into 5 groups as: Group C (control, n=6), Group S (sham; underwent only left scrotal exploration, n=7), Group TD (torsion and detorsion; 6h of ischemia and 7days of reperfusion, n=7), Group TD/M (TD+Melatonin; 6h of ischemia and 7days of reperfusion and 7days of 17mg/kg intraperitoneal melatonin per day, n=7), group TD/Col (TD+Colchicine; 6h of ischemia and 7days of reperfusion and 7days of 1mg/kg oral colchicine per day, n=7)...
November 18, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27897404/doxorubicin-inhibits-muscle-inflammation-after-eccentric-exercise
#8
Sheng-Chih Huang, Jin-Fu Wu, Suchada Saovieng, Wei-Horng Chien, Ming-Fen Hsu, Xiao-Fei Li, Shin-Da Lee, Chih-Yang Huang, Chih-Yang Huang, Chia-Hua Kuo
BACKGROUND: Doxorubicin, a widely used anti-tumour drug, is known to cause muscle loss in cancer patients. METHODS: Following an acute dose of doxorubicin injection (2.5 mg/kg per body weight), we examined macrophage distribution in rat soleus muscle challenged by eccentric exercise (downhill running). Long-term doxorubicin treatment (one injection every 3 days) on muscle mass and survival were also determined. RESULTS: Under non-exercised condition, increased tumour necrosis factor (TNF)-alpha mRNA and decreased IL-10 mRNA were observed in soleus muscle of doxorubicin-treated rats, compared with saline-treated control rats...
October 10, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27888159/transmembrane-tnf-alpha-reverse-signaling-leading-to-tgf-beta-production-is-selectively-activated-by-tnf-targeting-molecules-therapeutic-implications
#9
REVIEW
Zsuzsa Szondy, Anna Pallai
Tumor necrosis factor (TNF)-α is a potent pro-inflammatory cytokine exerting pleiotropic effects on various cell types. It is synthesized in a precursor form called transmembrane TNF-α (mTNF-α) which, after being processed by metalloproteinases, is released in a soluble form to mediate its biological activities through Type 1 and 2 TNF receptors in TNF receptor expressing cells. In addition to acting in soluble form, TNF-α also acts in the transmembrane form both as a ligand by activating TNF receptors, as well as a receptor that transmits outside-to-inside (reverse) signals back into mTNF-α bearing cells...
November 22, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27888157/curcumin-use-in-pulmonary-diseases-state-of-the-art-and-future-perspectives
#10
REVIEW
Diana Lelli, Amirhossein Sahebkar, Thomas P Johnston, Claudio Pedone
Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa). It has been used for centuries in Ayurveda (Indian traditional medicine) for the treatment of several diseases. Over the last several decades, the therapeutic properties of curcumin have slowly been elucidated. It has been shown that curcumin has pleiotropic effects, regulating transcription factors (e.g., NF-kB), cytokines (e.g., IL6, TNF-alpha), adhesion molecules (e.g., ICAM-1), and enzymes (e.g., MMPs) that play a major role in inflammation and cancerogenesis...
November 22, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27886444/incidence-and-classification-of-cutaneous-manifestations-in-rheumatoid-arthritis
#11
Mirjana Ziemer, Anne-Katrin Müller, Gert Hein, Peter Oelzner, Peter Elsner
BACKGROUND AND OBJECTIVE: There have only been few studies examining rheumatoid arthritis (RA)-related skin manifestations in larger patient populations. Herein, we present current data on the prevalence and spectrum of cutaneous lesions in RA, addressing disease activity scores, anti-CCP antibodies as well as novel pharmacological approaches. PATIENTS AND METHODS: Between November 2006 and July 2007, 214 patients with RA treated at the Division of Rheumatology, University Hospital Jena, Germany, were prospectively examined...
November 25, 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27885712/a-randomized-controlled-trial-comparing-lactulose-plus-albumin-versus-lactulose-alone-for-treatment-of-hepatic-encephalopathy
#12
Barjesh Chander Sharma, Jatinderpal Singh, Siddharth Srivastava, Alok Sangam, Alok Kumar Mantri, Nirupma Trehanpati, Shiv Kumar Sarin
BACKGROUND: Hepatic encephalopathy (HE) is associated with poor prognosis and treatment of HE is primarily directed at the reduction of the blood ammonia levels. We evaluated the efficacy and safety of albumin plus lactulose versus lactulose alone for treatment of overt HE. METHODS: In prospective randomized controlled trial, 120 patients with overt HE were randomized in 2 groups; group A lactulose plus albumin (n = 60) and group B, lactulose alone (n = 60)...
November 25, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27879319/amp-activated-kinase-ampk-promotes-innate-immunity-and-antiviral-defense-through-modulation-of-stimulator-of-interferon-genes-sting-signaling
#13
Daniel Prantner, Darren J Perkins, Stefanie N Vogel
The host protein Stimulator of Interferon Genes (STING) has been shown to be essential for recognition of both viral and intracellular bacterial pathogens, but its regulation remains unclear. Previously, we reported that mitochondrial membrane potential regulates STING-dependent IFN-beta induction independently of ATP synthesis. Since mitochondrial membrane potential controls calcium homeostasis, and AMP-activated protein kinase (AMPK) is regulated, in part, by intracellular calcium, we postulated that AMPK participates in STING activation; however, its role has yet to be been defined...
November 22, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27875990/inverse-relationship-between-alzheimer-s-disease-and-cancer-and-other-factors-contributing-to-alzheimer-s-disease-a-systematic-review
#14
Ovais Shafi
BACKGROUND: The AD etiology is yet not properly known. Interactions among environmental factors, multiple susceptibility genes and aging, contribute to AD. This study investigates the factors that play role in causing AD and how changes in cellular pathways contribute to AD. METHODS: PUBMED database, MEDLINE database and Google Scholar were searched with no date restrictions for published articles involving cellular pathways with roles in cancers, cell survival, growth, proliferation, development, aging, and also contributing to Alzheimer's disease...
November 22, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27843953/considerations-for-defining-cytokine-dose-duration-and-milieu-that-are-appropriate-for-modeling-chronic-low-grade-inflammation-in-type-2-diabetes
#15
REVIEW
Craig S Nunemaker
Proinflammatory cytokines have been implicated in the pathophysiology of both type 1 diabetes (T1D) and type 2 diabetes (T2D). T1D is an autoimmune disease involving the adaptive immune system responding to pancreatic beta-cells as antigen-presenting cells. This attracts immune cells that surround pancreatic islets (insulitis) and secrete cytokines, such as IL-1beta, IFN-gamma, and TNF-alpha, in close proximity to pancreatic beta-cells. In contrast, there is little evidence for such a focused autoimmune response in T2D...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27835955/acute-effects-of-exercise-on-the-inflammatory-state-in-patients-with-idiopathic-pulmonary-arterial-hypertension
#16
Lars Harbaum, Emilia Renk, Sara Yousef, Antonia Glatzel, Nicole Lüneburg, Jan K Hennigs, Tim Oqueka, Hans J Baumann, Djordje Atanackovic, Ekkehard Grünig, Rainer H Böger, Carsten Bokemeyer, Hans Klose
BACKGROUND: Exercise training positively influences exercise tolerance and functional capacity of patients with idiopathic pulmonary arterial hypertension (IPAH). However, the underlying mechanisms are unclear. We hypothesized that exercise modulates the activated inflammatory state found in IPAH patients. METHODS: Single cardiopulmonary exercise testing was performed in 16 IPAH patients and 10 healthy subjects. Phenotypic characterization of peripheral blood mononuclear cells and circulating cytokines were assessed before, directly after and 1 h after exercise...
November 11, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27834446/high-cut-off-hemofiltration-versus-standard-hemofiltration-effect-on-plasma-cytokines
#17
Rafidah Atan, Leah Peck, Kumar Visvanathan, Narelle Skinner, Glenn Eastwood, Rinaldo Bellomo, Markus Storr, Hermann Goehl
PURPOSE: To study the effects of continuous veno-venous hemofiltration (CVVH) with high cut-off filters (CVVH-HCO) on plasma cytokine levels, sieving coefficient and clearance compared to CVVH using standard filters (CVVH-Std) in a nested cohort within a double-blind randomized controlled trial in severe acute kidney injury (AKI) patients. METHODS: We measured plasma and post-filter levels of IL-6, TNF-alpha, IL-8, IL-1 beta, RANTES, IL-10, IFN-gamma and IFN-alpha in both study groups...
November 11, 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/27833035/tumor-necrosis-factor-%C3%AE-in-the-onset-and-progression-of-leukemia
#18
REVIEW
Xiaoxi Zhou, Zhuoya Li, Jianfeng Zhou
Tumor necrosis factor alpha (TNF-α), originally described as an anti-neoplastic cytokine, has been found, in apparent contradiction to its name, to play an important role in promoting the development and progression of malignant disease. Targeting TNF-α with TNF antagonists has elicited an objective response in certain solid tumors in phase I and II clinical trials. This review focuses on the relationship of TNF-α expressed by leukemia cells and adverse clinical features of leukemia. TNF-α is involved in all steps of leukemogenesis, including cellular transformation, proliferation, angiogenesis, and extramedullary infiltration...
November 8, 2016: Experimental Hematology
https://www.readbyqxmd.com/read/27829308/sex-and-strain-based-inflammatory-response-to-repeated-tobacco-smoke-exposure-in-spontaneously-hypertensive-and-wistar-kyoto-rats
#19
Yi-Hsin Shen, Alexa K Pham, Benjamin Davis, Suzette Smiley-Jewell, Lei Wang, Urmila P Kodavanti, Minoru Takeuchi, Daniel J Tancredi, Kent E Pinkerton
CONTEXT: Approximately four million people die every year from chronic obstructive pulmonary disease (COPD), with more than 80% of the cases attributed to smoking. OBJECT: The purpose of this study was to examine the rat strain and sex-related differences and the extended tobacco smoke exposure to induce lung injury and inflammation with the goal of finding a suitable rodent model to study COPD. METHODS: Male and female spontaneously hypertensive (SH) and male Wistar Kyoto (WKY) rats were exposed to filtered air (FA) or to tobacco smoke (TS: 90 mg/m(3) particulate concentration) for 6 h/day, three days/week for 4 or 12 weeks...
November 10, 2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/27825290/antioxidant-and-anti-inflammatory-effects-of-nasturtium-officinale-involved-in-attenuation-of-gentamicin-induced-nephrotoxicity
#20
Somayeh Shahani, Farzaneh Behzadfar, Danial Jahani, Maryam Ghasemi, Fatemeh Shaki
BACKGROUND AND PURPOSE: Gentamicin (GM) is used against bacterial infections. The aim of our investigation was to evaluate the role of inflammation and also oxidative damage in nephrotoxic potential of GM and protective effects of Nasturtium officinale (watercress) against GM-induced nephrotoxicity in Wistar rats. MATERIAL AND METHOD: The animals were divided into eight groups: control, solvent, GM (80 mg/kg IP), GM with three doses (50,100, 200 mg/kg/day) of hydroalcoholic extract of watercress and one group only received high dose of extract and a group which received gentamicin plus vitamin E for 10 consecutive days...
November 8, 2016: Toxicology Mechanisms and Methods
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