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Collagenase clostridium histolyticum

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https://www.readbyqxmd.com/read/28507849/difference-in-success-treating-proximal-interphalangeal-and-metacarpophalangeal-joints-with-collagenase-results-of-208-treatments
#1
Karina Liv Hansen, Jens Christian Werlinrud, Søren Larsen, Tune Ipsen, Jens Lauritsen
BACKGROUND: Dupuytren disease (DD) is a fibroproliferative disorder of the palmar fasciae causing extension deficit and impaired hand function. Treatment with injection of collagenase clostridium histolyticum (CCH) is a nonsurgical treatment method. The aim of this study was to evaluate the difference in efficiency and recurrence at 12-month follow-up when treating metacarpophalangeal (MP) and proximal interphalangeal (PIP) joints with CCH. None of the patients had received previous treatments of their condition...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28502596/safety-profile-of-collagenase-clostridium-histolyticum-stratified-by-degree-of-penile-curvature-in-patients-with-peyronie-s-disease
#2
Wayne J G Hellstrom, Ronny B W Tan, Genzhou Liu
OBJECTIVE: To examine the safety of collagenase clostridium histolyticum (CCH) in adult males with penile curvature deformity <30°. Collagenase clostridium histolyticum is indicated for treatment of Peyronie's disease (PD) in adult males with palpable plaque and a penile curvature deformity ≥30° at start of therapy; however, during treatment, patients may receive CCH injections when penile curvature deformity is <30°. MATERIALS AND METHODS: Patients who received ≥2 CCH treatment cycles in 2 phase 3 studies (IMPRESS I and II) were included...
May 10, 2017: Urology
https://www.readbyqxmd.com/read/28483591/self-reported-clinical-meaningfulness-early-in-the-treatment-course-predicts-objective-outcomes-in-men-undergoing-collagenase-clostridium-histolyticum-injections-for-peyronie-s-disease
#3
Matthew J Ziegelmann, Boyd R Viers, Brian D Montgomery, Mary E Westerman, Joshua B Savage, Landon W Trost
OBJECTIVE: To compare perceived meaningfulness early in the course of collagenase clostridium histolyticum (CCH) with final outcomes in order to evaluate its utility as a predictor of efficacy. METHODS: A registry of patients undergoing CCH from March 2014 to September 2016 was maintained. Patients were recommended to complete four injection-cycles. After each cycle, patients completed a questionnaire that included, "If you stopped at this point, would you consider this a meaningful improvement for you?" Curve assessments were performed prior to and at therapy completion...
May 5, 2017: Urology
https://www.readbyqxmd.com/read/28473158/injectable-collagenase-versus-percutaneous-needle-fasciotomy-for-dupuytren-contracture-in-proximal-interphalangeal-joints-a%C3%A2-randomized-controlled-trial
#4
Simon Toftgaard Skov, Therkel Bisgaard, Per Søndergaard, Jeppe Lange
PURPOSE: Collagenase Clostridium histolyticum (CCH) injection was introduced commercially as a treatment for Dupuytren contracture following initial phase-3 investigations in 2009 with promising results. However, the efficacy of CCH has not been prospectively investigated in a direct comparison to other active treatments of Dupuytren contracture with more than 1-year follow-up, despite a wide and increasing clinical use. METHOD: In this prospective, independent, open-label, randomized controlled trial, (Clinicaltrials...
May 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28454897/collagenase-clostridium-histolyticum-in-the-treatment-of-urologic-disease-current-and-future-impact
#5
REVIEW
Andrew T Gabrielson, Jonathan T Spitz, Wayne J G Hellstrom
INTRODUCTION: Peyronie's disease (PD) is a connective tissue disorder resulting in the abnormal accumulation of type I to III collagen, fibrin, and disorganized elastic fibers in the tunica albuginea of the penis. Many medical and non-pharmacologic modalities have been used in the treatment of PD; however, these approaches have proved largely ineffective, with surgery being the only definitive treatment. Intralesional injection of collagenase Clostridium histolyticum (CCH) has recently become the gold standard for minimally invasive treatment of PD, and studies have suggested the role of CCH could expand to the treatment of other urologic conditions such as urethral stricture disease...
April 25, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28395998/changes-in-the-effects-of-peyronie-s-disease-after-treatment-with-collagenase-clostridium-histolyticum-male-patients-and-their-female-partners
#6
Irwin Goldstein, L Dean Knoll, Larry I Lipshultz, Ted Smith, Gregory J Kaufman, Chris G McMahon
INTRODUCTION: Collagenase Clostridium histolyticum (CCH) intralesional injection was efficacious for the management of Peyronie's disease (PD) in the double-blinded, randomized, placebo-controlled Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II (IMPRESS I and II). Little is known about the consequences of PD or treatment on the sexual partners of affected men. AIM: To assess the safety and efficacy of CCH treatment in men who received placebo in the IMPRESS I or II study and to evaluate the men's PD symptoms and partner bother as reported by female sexual partners...
April 5, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28389081/the-use-of-residual-collagenase-for-single-digits-with-multiple-joint-dupuytren-contractures
#7
Louis C Grandizio, Anil Akoon, Janice Heimbach, Jove Graham, Joel C Klena
PURPOSE: Standard 0.58 mg (0.25 mL) collagenase Clostridium histolyticum (CCH) preparations result in unused CCH that is often discarded. Our purpose was to assess the results on Dupuytren contractures affecting both the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints in the same digit utilizing an injection containing the maximum CCH volume that can be withdrawn from a single vial. METHODS: A consecutive series of patients with MCP and PIP cords in the same digit received a single treatment with 2 injections totaling 0...
April 4, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28347795/clinical-experience-with-penile-traction-therapy-among-men-undergoing-collagenase-clostridium-histolyticum-for-peyronie-s-disease
#8
Matthew J Ziegelmann, Boyd R Viers, Brian D Montgomery, Ross A Avant, Joshua B Savage, Landon W Trost
OBJECTIVES: To evaluate the outcomes in men undergoing Collagenase Clostridium histolyticum (CCH) with concurrent penile traction therapy (PTT) for the treatment of Peyronie's Disease (PD). METHODS: We identified patients treated with CCH between March 2014 and July 2016. Patients were recommended to perform modeling and PTT between injection series. A final curve assessment was performed after patients completed CCH. A prospective database was maintained, including patient reported frequency and duration of PTT...
March 24, 2017: Urology
https://www.readbyqxmd.com/read/28341067/treatment-of-recurrent-dupuytren-contracture-in-joints-previously-effectively-treated-with-collagenase-clostridium-histolyticum
#9
Brian J Bear, Clayton A Peimer, F Thomas D Kaplan, Gregory J Kaufman, James P Tursi, Ted Smith
PURPOSE: Collagenase Clostridium histolyticum (CCH) is approved for the treatment of adults with Dupuytren contracture with a palpable cord. This open-label, phase 4 study evaluated the safety and efficacy of CCH for the retreatment of recurrent contractures in joints that were previously effectively treated with CCH. METHODS: Patients participating in a long-term follow-up study who had contracture recurrence (increased ≥ 20° with a palpable cord) after successful treatment in the previous study were eligible...
May 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28280681/multiple-recurrences-in-aggressive-forms-of-dupuytren-s-disease-can-patients-benefit-from-repeated-selective-fasciectomy
#10
Sören Könneker, G Felix Broelsch, Nicco Krezdorn, Khaled Dastagir, Jörn W Kuhbier, Felix J Paprottka, Peter M Vogt
BACKGROUND: In Dupuytren's disease (DD), limited fasciectomy is the mainstay of surgical therapy in patients at risk of contractures and disease recurrences. New minimally invasive treatments such as injection of collagenase clostridium histolyticum have evolved as a common tool for the preliminary treatment of Dupuytren's contractures. However, recurrences and their therapy remain controversial. In this study, we evaluate the benefit of repeated limited fasciectomy in patients with aggressive forms of the disease and multiple recurrences of contractures...
February 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28280315/collagenase-clostridium-histolyticum-in-the-treatment-of-peyronie-s-disease-patient-selection-and-perspectives
#11
REVIEW
Paige K Kuhlmann, Kenneth J DeLay, James Anaissie, Wayne Jg Hellstrom, Faysal A Yafi
The safety and efficacy of the use of collagenase Clostridium histolyticum (CCH) for the treatment of Peyronie's disease has been confirmed over the past several years. However, identification of the ideal patient population for use of this treatment is not well established. Multiple studies have attempted to delineate various patient-specific factors that may predict response to treatment with CCH, with the intent of enhancing patient selection. To date, these include baseline curvature severity, duration of disease, disease phase at presentation, plaque calcification, baseline erectile function, plaque size, age, comorbid diabetes, previous penile trauma, responsiveness to first treatment cycle, baseline penile shortening or pain, prior treatment with intralesional injection, compliance with plaque modeling, and atypical curvature...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28217460/collagenase-clostridium-histolyticum-intralesional-injections-for-the-treatment-of-peyronie-s-disease-a-safety-profile
#12
EDITORIAL
Sylvia Yan, Tet Yap, Suks Minhas
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217459/complications-and-other-concerns-with-intralesional-injection-therapy-with-collagenase-clostridium-histolyticum-for-peyronie-s-disease
#13
EDITORIAL
Laurence A Levine
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217458/results-of-smsna-survey-regarding-complications-following-intralesional-injection-therapy-with-collagenase-clostridium-histolyticum-for-peyronie-s-disease
#14
EDITORIAL
Ates Kadioglu, Emre Salabas
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217457/expanding-the-role-of-injectable-collagenase-clostridium-histolyticum-for-the-treatment-of-active-phase-peyronie-s-disease
#15
COMMENT
Louis A Aliperti, Akanksha Mehta
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217456/re-results-of-smsna-survey-regarding-complications-following-intralesional-injection-therapy-with-collagenase-clostridium-histolyticum-for-peyronie-s-disease
#16
COMMENT
Barbara Kahn, Nelson Bennett
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28208540/re-peyronie-s-disease-and-injectable-collagenase-clostridium-histolyticum-safety-efficacy-and-improvements-in-subjective-symptoms
#17
Allen F Morey
No abstract text is available yet for this article.
March 2017: Journal of Urology
https://www.readbyqxmd.com/read/28187522/survey-of-patient-and-partner-satisfaction-following-collagenase-clostridium-histolyticum-treatment-for-peyronie-s-disease
#18
J Anaissie, F A Yafi, E J Traore, S C Sikka, W J G Hellstrom
Intralesional injection of collagenase Clostridium histolyticum (CCH) is a minimally invasive, Food and Drug Administration-approved, effective treatment for Peyronie's disease (PD). To assess the satisfaction of patients and their female sexual partners (FSP) following CCH therapy for PD, we conducted a retrospective review of the records of all patients treated with CCH for PD between 04/2014 and 03/2016. Collected variables included demographics, pre- and post-treatment sexual function, penile curvature, penile vascular findings, and treatment outcomes...
March 2017: Andrology
https://www.readbyqxmd.com/read/28181175/adverse-effects-of-collagenase-in-the-treatment-of-dupuytren-disease-a-systematic-review
#19
Rafael Sanjuan-Cerveró, Francisco J Carrera-Hueso, Pedro Vazquez-Ferreiro, Diego Gomez-Herrero
BACKGROUND: Collagenase clostridium histolyticum (CCH) has proven to be both safe and effective in the treatment of Dupuytren disease (DD). The medium-term outcomes are similar to those achieved with surgery, and most adverse effects are self-limiting and considered to be mild or moderate. OBJECTIVE: Our objective was to conduct a systematic review of the adverse effects of CCH in DD since the release of the drug to evaluate the incidence, severity, classification, and definitions of these effects...
April 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28160905/pain-associated-with-treatment-of-dupuytren-contracture-with-collagenase-clostridium-histolyticum
#20
Rafael Sanjuan-Cerveró, Francisco J Carrera-Hueso, Pedro Vazquez-Ferreiro, Narjis Fikri-Benbrahim, Nuria Franco-Ferrando, Clayton A Peimer
PURPOSE: The primary objective of this study was to quantify the degree of pain associated with collagenase Clostridium histolyticum (CCH) injection and to determine whether it is related to other factors in the intervention. METHODS: A prospective study of 135 patients was performed to evaluate pain at 3 points during treatment: (1) after CCH injection, using a numerical rating scale (NRS), (2) a binary (positive/negative) assessment before manipulation 24 hours after CCH and after removing the bandage, and (3) after joint manipulation performed with wrist block anesthesia...
February 2017: Journal of Hand Surgery
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