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Collagenase clostridium histolyticum

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https://www.readbyqxmd.com/read/28820255/discovery-of-a-potent-inhibitor-class-with-high-selectivity-towards-clostridial-collagenases
#1
Esther Schönauer, Andreas Martin Kany, Jörg Haupenthal, Kristina Hüsecken, Isabel Josephin Hoppe, Katrin Voos, Samir Yahiaoui, Brigitta Elsässer, Christian Ducho, Hans Brandstetter, Rolf W Hartmann
Secreted virulence factors like bacterial collagenases are conceptually attractive targets for fighting microbial infections. However, previous attempts to develop potent compounds against these metalloproteases failed to achieve selectivity against human metalloproteases such as MMPs. Using an SPR-based screening complemented with enzyme inhibition assays, we discovered an N-aryl mercaptoacetamide-based inhibitor scaffold that showed submicromolar affinities towards collagenase H (ColH) from the human pathogen Clostridium histolyticum...
August 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28817884/re-clinical-experience-with-penile-traction-therapy-among-men-undergoing-collagenase-clostridium-histolyticum-for-peyronie-disease
#2
Allen D Seftel
No abstract text is available yet for this article.
September 2017: Journal of Urology
https://www.readbyqxmd.com/read/28761877/basic-fibroblast-growth-factor-anchored-multilayered-mesenchymal-cell-sheets-accelerate-periosteal-bone-formation
#3
Kentaro Uchida, Gen Inoue, Osamu Matsushita, Kyosuke Horikawa, Hiroyuki Sekiguchi, Wataru Saito, Shotaro Takano, Hisako Fujimaki, Masayuki Miyagi, Masashi Takaso
Cell-based regenerative therapy has the potential to repair bone injuries or large defects that are recalcitrant to conventional treatment methods, including drugs and surgery. Here, we developed a multilayered cell-based bone formation system using cells coated with fibronectin-gelatin (FN-G) nanofilms. The multilayered mesenchymal cells (MLMCs) were formed after two days of culture and were shown to express higher levels of BMP-2 and VEGF compared to monolayer cultures of MCs. The MLMCs were used as a graft material in combination with a fusion protein consisting of basic fibroblast growth factor (bFGF), polycystic kidney disease (PKD) domain, and the collagen-binding domain (CBD) of Clostridium histolyticum collagenase...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28744308/recent-pathophysiological-aspects-of-peyronie-s-disease-role-of-free-radicals-rationale-and-therapeutic-implications-for-antioxidant-treatment-literature-review
#4
REVIEW
Gianni Paulis, Gennaro Romano, Luca Paulis, Davide Barletta
Peyronie's disease (PD) is a chronic inflammation of tunica albuginea of the corpora cavernosa that causes an inelastic plaque resulting in penis deformation. Although its etiology is not completely known, there is general consensus that PD is genetically transmitted and secondary to penile trauma. In recent years, numerous studies demonstrated the role played by oxidative stress in PD pathogenesis, and other studies have described successful use of antioxidants in PD treatment. Oxidative stress is an integral part of this disease, influencing its progression...
2017: Advances in Urology
https://www.readbyqxmd.com/read/28635316/complications-following-collagenase-treatment-for-dupuytren-contracture
#5
Jennifer Wozniczka, Clifford Canepa, Adam Mirarchi, Joel S Solomon
BACKGROUND: Collagenase Clostridium histolyticum (CCH) injection and manipulation is a relatively new method for treating Dupuytren contracture that is growing in popularity. Although side effects such as swelling and ecchymosis are common, they are typically mild and self-limited. Major complications are rare but have included flexor tendon rupture and complex regional pain syndrome. METHODS: This study describes a case report of 2 patients seen at our institution...
June 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28612401/safety-and-effectiveness-of-collagenase-clostridium-histolyticum-cch-xiapex-%C3%A2-in-the-treatment-of-peyronie-s-disease-using-a-new-modified-shortened-protocol
#6
Amr Abdel Raheem, Marco Capece, Odunayo Kalejaiye, Tarek Abdel-Raheem, Marco Falcone, Mark Johnson, Oliver George Ralph, Giulio Garaffa, Andrew Nim Christopher, David John Ralph
OBJECTIVES: To evaluate the efficacy and safety of collagenase clostridium histolyticum (CCH) (Xiapex(®) , Xiaflex(®) ) in the treatment of Peyronie's disease (PD) using a new modified treatment protocol which aims at reducing the number of injections needed and reducing patient visits, thus reducing the cost and duration of treatment. PATIENTS AND METHODS: A prospective study of 53 patients with PD who had treatment with CCH at a single center using a new modified protocol...
June 14, 2017: BJU International
https://www.readbyqxmd.com/read/28604542/outcome-of-dupuytren-contractures-after-collagenase-clostridium-histolyticum-injection-a-single-institution-experience
#7
Yin Kan Hwee, Daniel Park, Marisa Vinas, Christopher Litts, David Friedman
BACKGROUND: Collagenase clostridium histolyticum (CCH) injection is an alternative to surgery for patients with Dupuytren disease (DD) of the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints. The success of surgical and nonsurgical treatment modalities for DD is reported to vary widely between 25% and 80% (J Bone Joint Surg Am. 1985;67:1439-1443; Plast Reconstr Surg. 2007;120:44e-54e; J Bone Joint Surg Am. 2007;89:189-198; J Hand Surg Am. 2011:36:936-942; J Hand Surg Am...
August 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28554517/factors-associated-with-erectile-dysfunction-and-the-peyronie-s-disease-questionnaire-in-patients-with-peyronie-s-disease
#8
Ege C Serefoglu, Ted M Smith, Gregory J Kaufman, Genzhou Liu, Faysal A Yafi, Wayne J G Hellstrom
OBJECTIVE: To elucidate patient characteristics that impact symptom-related bother and erectile function in patients with Peyronie's disease (PD). METHODS: A post hoc analysis used data from patients with PD (ie, had PD symptoms ≥12 months and penile curvature deformity of 30-90 degrees) who received ≥1 injection of study medication in two phase 3 trials of collagenase clostridium histolyticum (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies [IMPRESS-I; n = 417] and IMPRESS-II [n = 415])...
May 26, 2017: Urology
https://www.readbyqxmd.com/read/28507849/difference-in-success-treating-proximal-interphalangeal-and-metacarpophalangeal-joints-with-collagenase-results-of-208-treatments
#9
Karina Liv Hansen, Jens Christian Werlinrud, Søren Larsen, Tune Ipsen, Jens Lauritsen
BACKGROUND: Dupuytren disease (DD) is a fibroproliferative disorder of the palmar fasciae causing extension deficit and impaired hand function. Treatment with injection of collagenase clostridium histolyticum (CCH) is a nonsurgical treatment method. The aim of this study was to evaluate the difference in efficiency and recurrence at 12-month follow-up when treating metacarpophalangeal (MP) and proximal interphalangeal (PIP) joints with CCH. None of the patients had received previous treatments of their condition...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28502596/safety-profile-of-collagenase-clostridium-histolyticum-stratified-by-degree-of-penile-curvature-in-patients-with-peyronie-disease
#10
Wayne J G Hellstrom, Ronny B W Tan, Genzhou Liu
OBJECTIVE: To examine the safety of collagenase clostridium histolyticum (CCH) in adult men with penile curvature deformity <30°. CCH is indicated for treatment of Peyronie disease in adult men with palpable plaque and a penile curvature deformity ≥30° at start of therapy; however, during treatment, patients may receive CCH injections when penile curvature deformity is <30°. MATERIALS AND METHODS: Patients who received ≥2 CCH treatment cycles in 2 phase 3 studies (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II) were included...
August 2017: Urology
https://www.readbyqxmd.com/read/28483591/self-reported-clinical-meaningfulness-early-in-the-treatment-course-predicts-objective-outcomes-in-men-undergoing-collagenase-clostridium-histolyticum-injections-for-peyronie-disease
#11
Matthew J Ziegelmann, Boyd R Viers, Brian D Montgomery, Mary E Westerman, Joshua B Savage, Landon W Trost
OBJECTIVE: To compare perceived meaningfulness early in the course of collagenase Clostridium histolyticum (CCH) with final outcomes to evaluate its use as a predictor of efficacy. MATERIALS AND METHODS: A registry of patients undergoing CCH from March 2014 to September 2016 was maintained. Patients were recommended to complete 4 injection cycles. After each cycle, patients completed a questionnaire that included, "If you stopped at this point, would you consider this a meaningful improvement for you?" Curve assessments were performed before and at therapy completion...
August 2017: Urology
https://www.readbyqxmd.com/read/28473158/injectable-collagenase-versus-percutaneous-needle-fasciotomy-for-dupuytren-contracture-in-proximal-interphalangeal-joints-a%C3%A2-randomized-controlled-trial
#12
Simon Toftgaard Skov, Therkel Bisgaard, Per Søndergaard, Jeppe Lange
PURPOSE: Collagenase Clostridium histolyticum (CCH) injection was introduced commercially as a treatment for Dupuytren contracture following initial phase-3 investigations in 2009 with promising results. However, the efficacy of CCH has not been prospectively investigated in a direct comparison to other active treatments of Dupuytren contracture with more than 1-year follow-up, despite a wide and increasing clinical use. METHOD: In this prospective, independent, open-label, randomized controlled trial, (Clinicaltrials...
May 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28454897/collagenase-clostridium-histolyticum-in-the-treatment-of-urologic-disease-current-and-future-impact
#13
REVIEW
Andrew T Gabrielson, Jonathan T Spitz, Wayne J G Hellstrom
INTRODUCTION: Peyronie's disease (PD) is a connective tissue disorder resulting in the abnormal accumulation of type I to III collagen, fibrin, and disorganized elastic fibers in the tunica albuginea of the penis. Many medical and non-pharmacologic modalities have been used in the treatment of PD; however, these approaches have proved largely ineffective, with surgery being the only definitive treatment. Intralesional injection of collagenase Clostridium histolyticum (CCH) has recently become the gold standard for minimally invasive treatment of PD, and studies have suggested the role of CCH could expand to the treatment of other urologic conditions such as urethral stricture disease...
April 25, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28395998/changes-in-the-effects-of-peyronie-s-disease-after-treatment-with-collagenase-clostridium-histolyticum-male-patients-and-their-female-partners
#14
Irwin Goldstein, L Dean Knoll, Larry I Lipshultz, Ted Smith, Gregory J Kaufman, Chris G McMahon
INTRODUCTION: Collagenase Clostridium histolyticum (CCH) intralesional injection was efficacious for the management of Peyronie's disease (PD) in the double-blinded, randomized, placebo-controlled Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II (IMPRESS I and II). Little is known about the consequences of PD or treatment on the sexual partners of affected men. AIM: To assess the safety and efficacy of CCH treatment in men who received placebo in the IMPRESS I or II study and to evaluate the men's PD symptoms and partner bother as reported by female sexual partners...
June 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28389081/the-use-of-residual-collagenase-for-single-digits-with-multiple-joint-dupuytren-contractures
#15
Louis C Grandizio, Anil Akoon, Janice Heimbach, Jove Graham, Joel C Klena
PURPOSE: Standard 0.58 mg (0.25 mL) collagenase Clostridium histolyticum (CCH) preparations result in unused CCH that is often discarded. Our purpose was to assess the results on Dupuytren contractures affecting both the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints in the same digit utilizing an injection containing the maximum CCH volume that can be withdrawn from a single vial. METHODS: A consecutive series of patients with MCP and PIP cords in the same digit received a single treatment with 2 injections totaling 0...
April 4, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28347795/clinical-experience-with-penile-traction-therapy-among-men-undergoing-collagenase-clostridium-histolyticum-for-peyronie-disease
#16
Matthew J Ziegelmann, Boyd R Viers, Brian D Montgomery, Ross A Avant, Joshua B Savage, Landon W Trost
OBJECTIVE: To evaluate the outcomes in men undergoing collagenase Clostridium histolyticum (CCH) with concurrent penile traction therapy (PTT) for the treatment of Peyronie disease (PD). MATERIALS AND METHODS: We identified patients treated with CCH between March 2014 and July 2016. Patients were recommended to perform modeling and PTT between injection series. A final curve assessment was performed after patients completed CCH. A prospective database was maintained, including patient-reported frequency and duration of PTT...
March 24, 2017: Urology
https://www.readbyqxmd.com/read/28341067/treatment-of-recurrent-dupuytren-contracture-in-joints-previously-effectively-treated-with-collagenase-clostridium-histolyticum
#17
Brian J Bear, Clayton A Peimer, F Thomas D Kaplan, Gregory J Kaufman, James P Tursi, Ted Smith
PURPOSE: Collagenase Clostridium histolyticum (CCH) is approved for the treatment of adults with Dupuytren contracture with a palpable cord. This open-label, phase 4 study evaluated the safety and efficacy of CCH for the retreatment of recurrent contractures in joints that were previously effectively treated with CCH. METHODS: Patients participating in a long-term follow-up study who had contracture recurrence (increased ≥ 20° with a palpable cord) after successful treatment in the previous study were eligible...
May 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28280681/multiple-recurrences-in-aggressive-forms-of-dupuytren-s-disease-can-patients-benefit-from-repeated-selective-fasciectomy
#18
Sören Könneker, G Felix Broelsch, Nicco Krezdorn, Khaled Dastagir, Jörn W Kuhbier, Felix J Paprottka, Peter M Vogt
BACKGROUND: In Dupuytren's disease (DD), limited fasciectomy is the mainstay of surgical therapy in patients at risk of contractures and disease recurrences. New minimally invasive treatments such as injection of collagenase clostridium histolyticum have evolved as a common tool for the preliminary treatment of Dupuytren's contractures. However, recurrences and their therapy remain controversial. In this study, we evaluate the benefit of repeated limited fasciectomy in patients with aggressive forms of the disease and multiple recurrences of contractures...
February 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28280315/collagenase-clostridium-histolyticum-in-the-treatment-of-peyronie-s-disease-patient-selection-and-perspectives
#19
REVIEW
Paige K Kuhlmann, Kenneth J DeLay, James Anaissie, Wayne Jg Hellstrom, Faysal A Yafi
The safety and efficacy of the use of collagenase Clostridium histolyticum (CCH) for the treatment of Peyronie's disease has been confirmed over the past several years. However, identification of the ideal patient population for use of this treatment is not well established. Multiple studies have attempted to delineate various patient-specific factors that may predict response to treatment with CCH, with the intent of enhancing patient selection. To date, these include baseline curvature severity, duration of disease, disease phase at presentation, plaque calcification, baseline erectile function, plaque size, age, comorbid diabetes, previous penile trauma, responsiveness to first treatment cycle, baseline penile shortening or pain, prior treatment with intralesional injection, compliance with plaque modeling, and atypical curvature...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28217460/collagenase-clostridium-histolyticum-intralesional-injections-for-the-treatment-of-peyronie-s-disease-a-safety-profile
#20
EDITORIAL
Sylvia Yan, Tet Yap, Suks Minhas
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
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