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Collagenase clostridium histolyticum

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https://www.readbyqxmd.com/read/27872029/association-between-infertility-and-sexual-dysfunction-in-men-and-women
#1
REVIEW
Michael H Berger, Marisa Messore, Alexander W Pastuszak, Ranjith Ramasamy
INTRODUCTION: The relation between infertility and sexual dysfunction can be reciprocal. Causes of sexual dysfunction that affect fertility include erectile dysfunction, Peyronie's disease (abnormal penile curvature), low libido, ejaculatory disorders in men, and genito-pelvic pain/penetration disorder (GPPPD) and low sexual desire in women. AIM: To review the association between infertility and sexual dysfunction and discuss current management strategies to address sexual disorders in couples with infertility...
October 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27816605/impact-of-number-of-cycles-of-collagenase-clostridium-histolyticum-on-outcomes-in-patients-with-peyronie-s-disease
#2
James Anaissie, Faysal A Yafi, Kenneth J DeLay, Elizabeth J Traore, Suresh C Sikka, Wayne J G Hellstrom
OBJECTIVE: To analyze the impact of the number of cycles of collagenase Clostridium histolyticum (CCH) intralesional injection therapy on outcomes in order to further characterize CCH therapy. METHODS: We conducted a retrospective review of the records of all patients treated with CCH for PD between 04/2014 and 03/2016. Collected variables included demographics, pre- and post-treatment sexual function, penile curvature, penile vascular findings, and treatment outcomes...
November 2, 2016: Urology
https://www.readbyqxmd.com/read/27770352/collagenase-clostridium-histolyticum-for-the-treatment-of-peyronie-s-disease-a-real-world-clinical-perspective
#3
James Anaissie, Wayne J G Hellstrom, Faysal A Yafi
The introduction of collagenase Clostridium histolyticum (CCH) as a treatment option for Peyronie's disease (PD), defined as the abnormal formation of collagen on the tunica albuginea of the penis, has provided patients with a promising new conservative therapy. Studies have shown that CCH improves curvature by an average of 17°, and although patient and sexual partner satisfaction is high, the improvement has arguable clinical implications. Similarly, the efficacy and cost of CCH contrasts strongly with more invasive surgical management, and is further limited by rare, but serious, complications and several contraindications...
October 21, 2016: Drugs
https://www.readbyqxmd.com/read/27682305/effectiveness-and-safety-of-collagenase-clostridium-histolyticum-in-dupuytren-s-disease%C3%A2-an-observational-study-in-belgium
#4
F Verstreken, I Degreef, A Decramer, K Libberecht, W Vanhove, A Datco, J Vanhaecke, D Clermont, J Duerinckx
Dupuytren's disease is a connective tissue disorder leading to contractures. It can be treated surgically or through injections of collagenase Clostridium histolyticum (CCH). Patients with Dupuytren's contracture (> 20°) and a palpable cord were included in this observational study, aiming to characterise the Belgian patient population and to assess the effectiveness and safety of CCH. Overall, 108 patients (114 joints) received at least one injection of CCH, and 104 patients completed the study. The percentages of joints achieving a degree of contracture of 5° or less, or a relative contracture reduction of at least 50% after the extension procedure were 64...
August 2016: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/27649672/toxic-dermatitis-secondary-to-treatment-with-collagenase-clostridium-histolyticum-for-dupuytren%C3%A2-s-disease
#5
R Sanjuan-Cervero, J E Poquet-Jornet, F J Carrera-Hueso
OBJECTIVE: Secondary effects and drug reactions relative to collagenase Clostridium histolyticum treatment for Dupuytren's contracture are frequent. In only a few cases these secondary effects are considered serious. The mechanism that produces these effects of production is not well understood. CLINICAL REPORT: We present the case report of a woman with fifth finger interphalangeal joint treatment with generalized skin rash as a complication of collagenase Clostridium histolyticum treatment...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27588686/cloning-purification-and-characterization-of-the-collagenase-cola-expressed-by-bacillus-cereus-atcc-14579
#6
Carmen M Abfalter, Esther Schönauer, Karthe Ponnuraj, Markus Huemer, Gabriele Gadermaier, Christof Regl, Peter Briza, Fatima Ferreira, Christian G Huber, Hans Brandstetter, Gernot Posselt, Silja Wessler
Bacterial collagenases differ considerably in their structure and functions. The collagenases ColH and ColG from Clostridium histolyticum and ColA expressed by Clostridium perfringens are well-characterized collagenases that cleave triple-helical collagen, which were therefore termed as ´true´ collagenases. ColA from Bacillus cereus (B. cereus) has been added to the collection of true collagenases. However, the molecular characteristics of B. cereus ColA are less understood. In this study, we identified ColA as a secreted true collagenase from B...
2016: PloS One
https://www.readbyqxmd.com/read/27547932/-comparative-cost-effectiveness-of-clostridium-histolyticum-collagenase-xiapex%C3%A2-and-partial-fasciectomy-for-the-treatment-of-dupuytren-s-contracture-in-austria
#7
M Neuwirth, A Binter, W Pipam, M Rab
INTRODUCTION: Since Dupuytren's contracture is a common disorder, the costs for its surgical treatment impose a considerable burden on the healthcare system. For the first time in the German-speaking area, this study aimed to provide a comparative cost-effectiveness analysis for partial fasciectomy vs. treatment with Clostridium histolyticum collagenase (CCH). METHODS: A retrospective monocentric study of the period from 2012 to 2014 comprised 40 patients with previously untreated Dupuytren's contracture of one finger...
August 2016: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/27546441/the-impact-of-collagenase-clostridium-histolyticum-introduction-on-dupuytren-treatment-patterns-in-the-united-states
#8
John Z Zhao, Scott Hadley, Emerson Floyd, Brandon E Earp, Philip E Blazar
PURPOSE: The U.S. Food and Drug Administration approved the use of collagenase Clostridium histolyticum (CCH) in the United States in February 2010. This study addresses the impact of that approval on the number of Dupuytren contracture (DC) encounters and treatment patterns in the United States. METHODS: Using the Intercontinental Marketing Services Health Office-Based Medical Claims database, we identified the monthly number of DC encounters and DC procedures between January 2007 and December 2013...
October 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27544298/review-of-management-options-for-patients-with-atypical-peyronie-s-disease
#9
Faysal A Yafi, Georgios Hatzichristodoulou, Kenneth J DeLay, Wayne J G Hellstrom
INTRODUCTION: Peyronie's disease (PD) is a wound-healing disorder of the tunica albuginea often associated with penile deformity. Less commonly, patients with PD might display atypical presentations such as ventral curvature, hourglass deformity, significantly shortened penis, and/or multiplanar curvature. AIM: To review the available literature on the prevalence of and management options for atypical PD. METHODS: A literature review was performed through PubMed from 1982 through 2016 regarding atypical PD...
August 17, 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27428598/to-remember-radiotherapy-a-successful-treatment-for-early-dupuytren-s-disease
#10
B Eberlein, T Biedermann
Dupuytren's disease (DD) is a common fibroproliferative condition of the hand which tends to cause progressive digital flexion contracture. Therapeutic strategies to treat the disease include radiotherapy, injections of collagenase clostridium histolyticum, needle fasciotomy and extended surgical intervention dependent on involvement and duration of the disease. We have reviewed the literature with the aim to assess the conditions and effects of radiotherapy in DD. In early stages of the disease, radiotherapy resulted in regression of symptoms/a lack of progression found on average in 40% (range 10-85%)/81% (range 50-100%) of the patients with recurrence rates of only 12-31% after long-term follow-up (>4 years)...
October 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27373458/high-speed-atomic-force-microscopy-reveals-strongly-polarized-movement-of-clostridial-collagenase-along-collagen-fibrils
#11
Takahiro Watanabe-Nakayama, Masahiro Itami, Noriyuki Kodera, Toshio Ando, Hiroki Konno
Bacterial collagenases involved in donor infection are widely applied in many fields due to their high activity and specificity; however, little is known regarding the mechanisms by which bacterial collagenases degrade insoluble collagen in host tissues. Using high-speed atomic force microscopy, we simultaneously visualized the hierarchical structure of collagen fibrils and the movement of a representative bacterial collagenase, Clostridium histolyticum type I collagenase (ColG), to determine the relationship between collagen structure and collagenase movement...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27365982/evaluation-of-skin-anti-aging-potential-of-citrus-reticulata-blanco-peel
#12
Vinita D Apraj, Nancy S Pandita
BACKGROUND: The peel of Citrus reticulata Blanco is traditionally used as tonic, stomachic, astringent, and carminative. It is also useful in skin care. OBJECTIVE: To study the anti-aging potential of alcoholic extracts of C. reticulata Blanco peel using in vitro antioxidant and anti-enzyme assays. MATERIALS AND METHODS: Plant extracts were obtained by Soxhlation (CR HAE- Hot Alcoholic Extract of Citrus reticulata) and maceration method (CR CAE- Cold Alcoholic Extract of Citrus reticulata)...
July 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27313184/efficacy-and-safety-of-collagenase-clostridium-histolyticum-injection-for-dupuytren-s-contracture-in-non-caucasian-japanese-patients-cord-j-study-the-first-clinical-trial-in-a-non-caucasian-population
#13
H Hirata, K Tanaka, A Sakai, R Kakinoki, H Ikegami, N Tateishi
: To assess the efficacy, safety and pharmacokinetics of 0.58 mg collagenase Clostridium histolyticum injections for the treatment of Dupuytren's contracture in Japanese patients, we conducted a phase III, multicentre, uncontrolled, open-label clinical study in patients with Dupuytren's contracture. Of the 77 patients, 66 achieved clinical success in the primary treated joint (86%; 95% confidence interval: 76% to 93%), confirming the efficacy of collagenase Clostridium histolyticum injections...
June 16, 2016: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/27297798/adipose-tissue-microbiota-in-humans-an-open-issue
#14
A Zulian, R Cancello, E Cesana, E Rizzi, C Consolandi, M Severgnini, V Panizzo, A M Di Blasio, G Micheletto, C Invitti
BackgroundA specific "adipose tissue" microbiota has been recently identified in mice and hypothesized in humans. The purpose of this study was to verify the presence of microbiota of human whole adipose tissue and isolated adipocytes by combining culture-dependent and independent methods.MethodsStandard microbiological cultural techniques and 16S ribosomal RNA (16S rRNA) gene sequencing (Illumina technology) on DNA and RNA were employed to study a) whole abdominal subcutaneous (SAT) and visceral (VAT) adipose tissue from 14 obese and 5 normal-weight subjects, b) mature adipocytes isolated from SAT and VAT after collagenase digestion or mechanical separation...
June 14, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27251756/a-non-aggressive-highly-efficient-enzymatic-method-for-dissociation-of-human-brain-tumors-and-brain-tissues-to-viable-single-cells
#15
Ilan Volovitz, Netanel Shapira, Haim Ezer, Aviv Gafni, Merav Lustgarten, Tal Alter, Idan Ben-Horin, Ori Barzilai, Tal Shahar, Andrew Kanner, Itzhak Fried, Igor Veshchev, Rachel Grossman, Zvi Ram
BACKGROUND: Conducting research on the molecular biology, immunology, and physiology of brain tumors (BTs) and primary brain tissues requires the use of viably dissociated single cells. Inadequate methods for tissue dissociation generate considerable loss in the quantity of single cells produced and in the produced cells' viability. Improper dissociation may also demote the quality of data attained in functional and molecular assays due to the presence of large quantities cellular debris containing immune-activatory danger associated molecular patterns, and due to the increased quantities of degraded proteins and RNA...
2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27247629/collagenase-clostridium-histolyticum-in-the-management-of-peyronie-s-disease-a-review-of-the-evidence
#16
REVIEW
Elizabeth J Traore, William Wang, Faysal A Yafi, Wayne J G Hellstrom
OBJECTIVES: Peyronie's disease (PD) is a connective tissue disorder resulting in the abnormal accumulation of scar or plaques in the tunica albuginea of the penis. The condition is characterized by two phases: an active, inflammatory phase, and a stable, chronic phase. Collagenase Clostridium histolyticum (CCH) was isolated in the mid-1900s and postulated as a potential pharmacologic strategy for breaking down the abnormal connective tissue plaques of PD. Prior to the introduction of CCH, a wide variety of treatment modalities for PD were used in clinical practice, including oral and topical medications, intralesional injections, electromotive drug administration, extracorporeal shockwave therapy, traction, and invasive surgery, all with variable results...
June 2016: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/27232716/efficacy-and-safety-of-the-collagenase-of-the-bacterium-clostridium-histolyticum-for-the-treatment-of-capsular-contracture-after-silicone-implants-ex-vivo-study-on-human-tissue
#17
Sebastian Fischer, Christoph Hirche, Yannick Diehm, Kristo Nuutila, Jurij Kiefer, Emre Gazyakan, Ericka M Bueno, Thomas Kremer, Ulrich Kneser, Bohdan Pomahac
BACKGROUND: The fibrotic capsule that surrounds silicone implants consists mainly of collagen. The FDA-approved collagenase of the bacterium clostridium histolyticum provides a reasonable treatment option. Safety and efficacy at the female breast site must be evaluated before clinical utilization. MATERIALS AND METHODS: We incubated 20 samples of fibrotic capsule as well as 12 full thickness skin grafts harvested from the female breast site for 24 hours with different doses of collagenase...
2016: PloS One
https://www.readbyqxmd.com/read/27211926/peyronie-s-disease-and-injectable-collagenase-clostridium-histolyticum-safety-efficacy-and-improvements-in-subjective-symptoms
#18
Kevin K Yang, Nelson Bennett
OBJECTIVE: To report on an early adopter series of collagenase Clostridium histolyticum (CCh) for Peyronie's disease (PD). Postapproval studies of CCh have been anticipated after recent Food and Drug Administration authorization of its use for men with PD as definitive and durable nonsurgical interventions have been long desired. MATERIALS AND METHODS: From May 2014 to October 2015, a database consisting of PD patients with >30° of penile curvature received CCh from a single provider at a single institution...
August 2016: Urology
https://www.readbyqxmd.com/read/27177523/loss-of-stiffness-in-collagen-rich-uterine-fibroids-after-digestion-with-purified-collagenase-clostridium-histolyticum
#19
Friederike L Jayes, Betty Liu, Franklin T Moutos, Maragatha Kuchibhatla, Farshid Guilak, Phyllis C Leppert
BACKGROUND: Uterine fibroids are a significant health problem. These common benign tumors occur in 70-80 percent of women before age 50 and often cause bleeding and pain and can interfere considerably with daily life. Current treatment options are limited. Fibroids contain substantial amounts of altered and disordered collagens which contribute to their bulk. Targeting these collagens directly presents a novel treatment approach. OBJECTIVES: We sought to test the hypothesis that a highly purified collagenase clostridium histolyticum will digest interstitial collagen in uterine fibroids and reduce their stiffness and thereby evaluate the feasibility that Clostridium Histolyticum Collagenase can be developed into an alternative treatment for fibroids...
May 10, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27160746/corr-%C3%A2-ors-richard-a-brand-award-clinical-trials-of-a-new-treatment-method-for-adhesive-capsulitis
#20
Marie A Badalamente, Edward D Wang
BACKGROUND: Conservative and even surgical management of adhesive capsulitis often is prolonged and painful. Management of adhesive capsulitis is lacking evidence-based controlled clinical trials. QUESTIONS/PURPOSES: We asked: (1) Does a collagenase clostridium histolyticum (CCH) injection lyse shoulder capsule collagen in adhesive capsulitis and at what dose? (2) Can a shoulder capsule injection be administered extraarticularly? (3) Do CCH injections result in better scores for pain and function than can be achieved with physical therapy among patients with adhesive capsulitis? METHODS: First, 60 patients with adhesive capsulitis were evaluated by clinical examination...
November 2016: Clinical Orthopaedics and related Research
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