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Collagenase clostridium histolyticum

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https://www.readbyqxmd.com/read/29317799/intra-articular-collagenase-injection-increases-range-of-motion-in-a-rat-knee-flexion-contracture-model
#1
Kayleigh Wong, Guy Trudel, Odette Laneuville
Objectives: A knee joint contracture, a loss in passive range of motion (ROM), can be caused by prolonged immobility. In a rat knee immobilization flexion contracture model, the posterior capsule was shown to contribute to an irreversible limitation in ROM, and collagen pathways were identified as differentially expressed over the development of a contracture. Collagenases purified from Clostridium histolyticum are currently prescribed to treat Dupuytren's and Peyronie's contractures due to their ability to degrade collagen...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29310171/re-clinical-experience-with-penile-traction-therapy-among-men-undergoing-collagenase-clostridium-histolyticum-for-peyronie-disease
#2
Allen F Morey
No abstract text is available yet for this article.
January 2018: Journal of Urology
https://www.readbyqxmd.com/read/29305454/efficacy-and-adverse-effects-of-collagenase-use-in-the-treatment-of-dupuytren-s-disease-a-meta-analysis
#3
R Sanjuan-Cerveró, F J Carrera-Hueso, P Vazquez-Ferreiro, M A Ramon-Barrios
AIMS: The aim of this meta-analysis was to assess the safety and efficacy of collagenase clostridium histolyticum compared with fasciectomy and percutaneous needle fasciotomy (PNF) for Dupuytren's disease. MATERIALS AND METHODS: We systematically searched PubMed, EMBASE, LILACS, Web of Science, Cochrane, Teseo and the ClinicalTrials.gov registry for clinical trials and cohort or case-control studies which compared the clinical outcomes and adverse effects of collagenase with those of fasciectomy or PNF...
January 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29239395/treatment-of-peyronie-s-disease-via-preoperative-intralesional-collagenase-clostridium-histolyticum-followed-by-placement-of-an-inflatable-penile-prosthesis-the-new-standard-of-care
#4
EDITORIAL
Jason Akerman, Jason R Kovac
No abstract text is available yet for this article.
November 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29184789/effect-of-collagenase-clostridium-histolyticum-on-penile-vascular-and-morphological-parameters-in-patients-with-peyronie-s-disease
#5
Linley Diao, James Anaissie, Hoang Minh Tue Nguyen, Faysal A Yafi, Nora M Haney, Kenneth J DeLay, Taylor C Peak, Suresh C Sikka, Wayne J G Hellstrom
Background: To examine the changes in penile vascular parameters after the administration of collagenase Clostridium histolyticum (CCH) in patients with Peyronie's disease (PD). Methods: We retrospectively reviewed the records for all patients treated with CCH for PD between 04/2014 and 05/2017 who underwent penile duplex Doppler ultrasound (PDDU) after pharmacologically induced erection both before and after four cycles of CCH treatment. The primary outcomes measured were changes in peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index (RI) after CCH treatment...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29184788/racial-variations-in-response-to-intralesional-collagenase-clostridium-histolyticum-in-men-with-peyronie-s-disease
#6
Hoang Minh Tue Nguyen, Kenneth J DeLay, Linley Diao, Nora M Haney, James Anaissie, Faysal A Yafi, Suresh C Sikka, Wayne J G Hellstrom
Background: An examination of potential racial variations between Caucasian American (CA) and African American (AA) men in the efficacy and safety of collagenase clostridium histolyticum (CCH) in the treatment of Peyronie's disease (PD). Methods: We retrospectively reviewed the records for all patients treated with CCH for PD between 04/2014 and 05/2017. Patients were divided into two groups based on their self-reported race. The primary outcomes of interest were final change in curvature after CCH treatment regardless of number of CCH cycles received, and frequency of treatment-related adverse events (TRAEs)...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29181346/phalangeal-fracture-during-attempted-dupuytrens-release-following-clostridial-collagenase-injection-case-report
#7
Laura W Lewallen, Marco Rizzo
Introduction: Dupuytren's disease can be a challenging condition for both patients and surgeons. Injectable collagen clostridium histolyticum was approved for clinical use by the Food and Drug Administration in 2010. A number of side effects have been described. In this case report, we present a complication of a proximal phalanx fracture which occurred during attempted release post injection. To the best of our knowledge, this is the first reported case of this particular complication...
July 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29170879/factors-influencing-recurrence-and-progression-of-dupuytren-s-disease-treated-by-collagenase-clostridium-histolitycum
#8
Clarisa Simón-Pérez, Julian Alía-Ortega, Belen García-Medrano, Jose Ignacio Rodríguez-Mateos, Maria Brotat-Rodríguez, Hector Aguado-Hernandez, Miguel Angel Martín-Ferrero
AIM OF THE STUDY: The purpose of this study was to determine the recurrence rate, possible adverse reactions and factors influencing recurrence and progression of Dupuytren's disease (DD) treated with Collagenase from Clostridium histolyticum (CCH). METHOD: This was a prospective study of 71 patients with DD treated with CCH from 2011 to February 2013, with a minimum follow-up period of four years. Clinical, functional, patient satisfaction, drug safety and factors influencing recurrence and disease progression were evaluated...
November 23, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29144915/re-safety-and-effectiveness-of-collagenase-clostridium-histolyticum-in-the-treatment-of-peyronie-s-disease-using-a-new-modified-shortened-protocol
#9
Allen D Seftel
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29062633/comparative-effectiveness-of-needle-aponeurotomy-and-collagenase-injection-for-dupuytren-s-contracture-a-multicenter-study
#10
Chao Zhou, Steven E R Hovius, Adriana J Pieters, Harm P Slijper, Reinier Feitz, Ruud W Selles
BACKGROUND: Although the efficacy of collagenase clostridium histolyticum (CCH) injections has been demonstrated by randomized clinical trials, the relative effectiveness of CCH remains uncertain. Our aim was to compare the outcomes of CCH with those of percutaneous needle aponeurotomy (PNA) in daily clinical practice. METHODS: We analyzed data from patients undergoing PNA or CCH between 2011 and 2014 at 7 practice sites in the Netherlands. We examined the degree of improvement in contracture and adverse effects at 6-12 weeks after surgery or the last injection...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28993295/design-synthesis-and-collagenase-inhibitory-activity-of-some-novel-phenylglycine-derivatives-as-metalloproteinase-inhibitors
#11
Ankit Ganeshpurkar, Devendra Kumar, Sushil Kumar Singh
Metalloproteases are a class of proteases having metal ion(s) at their catalytic sites. Bacterial collagenases are involved in human gas gangrene, periodontal diseases, food etc. The Clostridium collagenase occurs in two isoforms COL_G and Col_H. The present work is based on the protein structure-based approach for the development of collagenase inhibitor. The sequence analysis and structural alignment of both isoforms showed significant similarity in active site except aspartate switch present in Col_H. The homology model was developed and validated for Col_H peptidase domain with open aspartate switch followed by the docking of designed ligands...
October 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28990520/collagenolytic-enzymes-and-their-applications-in-biomedicine
#12
Anatoly Borisovich Shekhter, Anastasia V Balakireva, Natalia V Kuznetsova, Marina N Vukolova, Petr F Litvitsky, Andrey A Zamyatnin
Nowadays, enzymatic therapy is a very promising line of treatment for many different diseases. There is a group of disorders and conditions, caused by fibrotic and scar processes and associated with the excessive accumulation of collagen that needs to be catabolized to normalize the connective tissue content. The human body normally synthesizes special extracellular enzymes, matrix metalloproteases (MMPs) by itself. These enzymes can cleave components of extracellular matrix (ECM) and different types of collagen and thus maintain the balance of the connective tissue components...
October 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28987724/effect-of-proanthocyanidin-enriched-extracts-on-the-inhibition-of-wear-and-degradation-of-dentin-demineralized-organic-matrix
#13
Ana Paula Boteon, Melissa Thiemi Kato, Marília Afonso Rabelo Buzalaf, Anuradha Prakki, Linda Wang, Daniela Rios, Heitor Marques Honório
OBJECTIVES: The aim of this study was to evaluate the effect of Cranberry and Grape seed-enriched extract gels in inhibiting wear and degradation of demineralized organic matrix (DOM). DESIGN: 225 dentin specimens obtained from bovine incisors were randomly allocated into 5 groups (n=45): 10% Grape seed extract gel (GSE), 10% Cranberry extract gel (CE), 0.012% Chlorhexidine gel (CX), 1.23% NaF gel (F), and no active compound gel (P, placebo). Before the treatments, samples were demineralized by immersion in 0...
September 25, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28974406/treatment-of-peyronie-s-disease-with-collagenase-clostridium-histolyticum-and-vacuum-therapy-a-randomized-open-label-pilot-study
#14
David J Ralph, Amr Abdel Raheem, Genzhou Liu
BACKGROUND: Collagenase Clostridium histolyticum (CCH) is indicated for the treatment of penile curvature in adult men with Peyronie's disease (PD) with palpable plaque and curvature deformity of at least 30° at the start of therapy. AIM: To evaluate the efficacy and safety of CCH plus vacuum-pump therapy with and without penile modeling for the management of PD. METHODS: Adult men with PD and penile curvature of at least 30° were randomly assigned to receive CCH 0...
November 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28923562/intralesional-injection-of-collagenase-clostridium-histolyticum-may-increase-the-risk-of-late-onset-penile-fracture
#15
REVIEW
Jonathan A Beilan, Jared J Wallen, Adam S Baumgarten, Kevin N Morgan, Justin L Parker, Rafael E Carrion
INTRODUCTION: The use of intralesional injection of collagenase Clostridium histolyticum (CCH) has become a valid treatment option in the management of Peyronie's disease (PD). Multiple studies have shown the drug's safety and efficacy. However, sparse literature exists on the utility of the injection protocol's 14-day "observation period," in which patients are instructed to abstain from all sexual activity. AIM: To summarize the contemporary literature and report on our series of patients treated with CCH in an effort to explore the effectiveness of the postinjection observation period...
September 8, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28886994/successful-treatment-of-residual-curvature-in-peyronie-disease-in-men-previously-treated-with-intralesional-collagenase-clostridium-histolyticum
#16
Kenneth DeLay, Linley Diao, Hoang Minh Tue Nguyen, Jonathan Zurawin, Russell Libby, Faysal Yafi, Wayne J G Hellstrom
OBJECTIVE: To determine the success and feasibility of surgically correcting residual curvature after intralesional collagenase clostridium histolyticum (CCH) for the treatment of Peyronie disease (PD). METHODS: We performed a retrospective analysis of patients who had intralesional CCH treatment for PD and who subsequently underwent penile plication (PP), plaque incision and grafting (PIG), or inflatable penile prosthesis (IPP) placement. RESULTS: Ten men who underwent PP, PIG, or IPP for the treatment of residual curvature after intralesional CCH were identified...
September 5, 2017: Urology
https://www.readbyqxmd.com/read/28879693/collagenase-clostridium-histolyticum-in-the-treatment-of-peyronie-s-disease-review-of-a-minimally-invasive-treatment-option
#17
REVIEW
Andrew T Gabrielson, Laith M Alzweri, Wayne Jg Hellstrom
Peyronie's disease (PD) is an inflammatory disorder characterized by an abnormal collagen deposition in the tunica albuginea of the penis, leading to fibrous and non-compliant plaques that can impede normal erection. Although pharmacological treatments are available, only intralesional injection therapy and surgical reconstruction have demonstrated tangible clinical efficacy in the management of this condition. Intralesional injection of collagenase clostridium histolyticum (CCH) has come to the forefront of minimally invasive treatment of PD...
September 6, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/28874331/safety-and-efficacy-of-collagenase-clostridium-histolyticum-in-the-treatment-of-acute-phase-peyronie-s-disease
#18
Hoang Minh Tue Nguyen, James Anaissie, Kenneth J DeLay, Faysal A Yafi, Suresh C Sikka, Wayne J G Hellstrom
BACKGROUND: Peyronie's disease (PD), defined as the abnormal formation of fibrous plaque(s) in the tunica albuginea of the penis, is a chronic condition that afflicts 3% to 13% of the US male population; there is no current research on the efficacy and safety of collagenase Clostridium histolyticum (CCH) in the treatment of acute phase PD. AIM: To examine the efficacy and safety of CCH in the treatment of acute-phase PD. METHODS: We retrospectively reviewed the records for all patients treated with CCH for PD from April 2014 through April 2017...
October 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28874327/collagenase-clostridium-histolyticum-in-the-treatment-of-peyronie-s-disease-a-review-of-the-literature-and-a-new-modified-protocol
#19
REVIEW
Amr Abdel Raheem, Mark Johnson, Tarek Abdel-Raheem, Marco Capece, David Ralph
INTRODUCTION: Peyronie's disease (PD) is a common condition that results in penile deformity, which makes sexual intercourse difficult or impossible, and causes psychological, emotional, and relationship difficulties for the man affected and his partner. Collagenase Clostridium histolyticum (CCH; Xiapex, Xiaflex) is the first licensed non-surgical treatment option for PD. The safety and efficacy have been demonstrated in two large phase III randomized controlled trials (IMPRESS I and IMPRESS II)...
September 2, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28854973/efficacy-and-safety-of-collagenase-clostridium-histolyticum-for-dupuytren-disease-nodules-a-randomized-controlled-trial
#20
Bronier Costas, Stephen Coleman, Greg Kaufman, Robert James, Brian Cohen, R Glenn Gaston
BACKGROUND: To determine the safety and efficacy of collagenase clostridium histolyticum (CCH) injection for the treatment of palmar Dupuytren disease nodules. METHODS: In this 8-week, double-blind trial, palpable palmar nodules on one hand of adults with Dupuytren disease were selected for treatment. Patients were randomly assigned using an interactive web response system to receive a dose of 0.25 mg, 0.40 mg, or 0.60 mg (1:1:1 ratio) and then allocated to active treatment (CCH) or placebo (4:1 ratio)...
August 30, 2017: BMC Musculoskeletal Disorders
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