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Collagenase clostridium histolyticum

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https://www.readbyqxmd.com/read/29774446/contemporary-review-of-peyronie-s-disease-treatment
#1
REVIEW
Edward Capoccia, Laurence A Levine
PURPOSE: To analyze the literature on the current treatment options for Peyronie's disease (PD). RECENT FINDINGS: Intracavernosal injection therapy using collagenase clostridium histolyticum (CCH) has been widely adopted since its FDA approval in 2013. Based on the current evidence, it appears to be moderately efficacious for men with mild curvatures. Although a recent study has shown similar outcomes using a modified protocol requiring fewer injections, CCH remains an expensive medication...
May 17, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29770338/basic-fibroblast-growth-factor-fused-with-tandem-collagen-binding-domains-from-clostridium-histolyticum-collagenase-colg-increases-bone-formation
#2
Hiroyuki Sekiguchi, Kentaro Uchida, Osamu Matsushita, Gen Inoue, Nozomu Nishi, Ryo Masuda, Nana Hamamoto, Takaki Koide, Shintaro Shoji, Masashi Takaso
Basic fibroblast growth factor 2 (bFGF) accelerates bone formation during fracture healing. Because the efficacy of bFGF decreases rapidly following its diffusion from fracture sites, however, repeated dosing is required to ensure a sustained therapeutic effect. We previously developed a fusion protein comprising bFGF, a polycystic kidney disease domain (PKD; s2b), and collagen-binding domain (CBD; s3) sourced from the Clostridium histolyticum class II collagenase, ColH, and reported that the combination of this fusion protein with a collagen-like peptide, poly(Pro-Hyp-Gly)10 , induced mesenchymal cell proliferation and callus formation at fracture sites...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29761688/collagenase-clostridium-histolyticum-a-novel-medical-treatment-for-peyronie-s-disease
#3
Amr Abdel Raheem, Mark Johnson, David Ralph, Giulio Garaffa
INTRODUCTION: Peyronie's disease (PD) affects up to 9% of the male population. PD causes scarring of the tunica albuginea of the penis which leads to penile deformity making sexual intercourse difficult or impossible. PD also causes significant psychological, emotional and relationship difficulties for both patient and partner. Up until the licencing of Collagenase clostridium histolyticum (CCH) (Xiapex®, Xiaflex®), surgical correction of the penile deformity was the mainstay of treatment...
May 14, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29741424/morphological-patterns-of-the-pretendinous-cord-in-dupuytren-s-disease-a-predictor-of-clinical-outcome
#4
P Vanek, J Strömberg, J Fridén, Y Aurell
The morphology of the pretendinous cord in Dupuytren's disease is poorly described in vivo and especially with respect to recurrence after treatment. This prospective study was designed to describe the morphology of Dupuytren's cords by ultrasound and to identify possible correlation between the ultrasonographic characteristics of these cords and the clinical outcomes two years after treatment. Thirty-nine patients with a contracture of at least 20° in the metacarpophalangeal (MCP) joint, who were scheduled for local treatment by either injectable collagenase clostridium histolyticum (CCH) or percutaneous needle fasciotomy (PNF), were examined by ultrasound...
May 9, 2018: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/29733116/collagenase-clostridium-histolyticum-for-the-treatment-of-peyronie-s-disease-a-prospective-italian-multicentric-study
#5
M Capece, A Cocci, G Russo, G Cito, G Giubilei, G Cacciamani, G Garaffa, M Falcone, M Timpano, G Tasso, F Sessa, R Campi, F Di Maida, T Cai, G Morelli, B Giammusso, P Verze, A Palmieri, D Ralph, V Mirone, N Mondaini
Peyronie's disease (PD) is a common condition which results in penile curvature making sexual intercourse difficult or impossible. Collagenase clostridium histolyticum (CCH) is the first licensed drug for the treatment of PD and is indicated in patients with palpable plaque and curvature deformity of at least 30° of curvature. However, only few monocentric studies are available in the current literature and this is the first national multicentric study focusing on this new treatment. In five Italian centres, 135 patients have completed the treatment with three injections of CCH using Ralph's shortened modified protocol...
May 7, 2018: Andrology
https://www.readbyqxmd.com/read/29726655/-collagenase-clostridium-histolyticum-for-peyronie-s-disease-a-new-minimally-invasive-and-effective-treatment
#6
REVIEW
Hao-Cheng Lin, Hai-Tao Zhang, Hui Jiang
The treatment of Peyronie's disease has been a challenge to urologists, as most of the current oral medications are considered hardly valid and the rest of the therapies require strict control of indications, some of which remain controversial, while the final surgical option may be associated with complications such as penile shortening or erectile dysfunction. Collagenase clostridium histolyticum has been proved to be effective in dissolving the penile cavernosal plaque and approved by the Food and Drug Administration of the USA as the first drug to be used for the treatment of Peyronie's disease...
September 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29726315/the-risk-of-skin-tear-in-dupuytren-s-disease-when-treated-with-collagenase
#7
Christian Fagernæs, Susanne Mallet
INTRODUCTION: The purpose of this study was to explore if there was a correlation between joint level and degree of contracture on the one hand and the risk of skin tear in Dupuytren's disease (DD) on the other, when treated with collagenase from Clostridium histolyticum. No trial or study has explored the risk of skin tear as primary outcome in a population that has not been treated for DD before. METHODS: A retrospective study of prospectively collected data was performed on patients with DD treated with collagenase from 1 August 2012 to 1 April 2014...
May 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29706551/anesthesia-for-collagenase-clostridium-histolyticum-injection-in-patients-with-dupuytren-disease-a-cohort-analysis
#8
Rafael Sanjuan-Cerveró, Francisco J Carrera-Hueso, Pedro Vazquez-Ferreiro, Clayton A Peimer
Procedural pain is one of the most common adverse effects reported by patients with Dupuytren disease (DD) treated with collagenase clostridium histolyticum (CCH). The aim of this study was to assess the effectiveness of wrist block before CCH injection in reducing procedural pain and to analyze its impact on adverse effects. We performed a prospective, single-center study in which we compared two groups of patients in a consecutive cohort. In the first group (NO-BLOCK), wrist block was only performed before finger extension, whereas in the second group (BLOCK), it was performed before CCH injection and finger extension...
April 12, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29699756/predictive-factors-of-patients-and-their-partners-sexual-function-improvement-after-collagenase-clostridium-histolyticum-injection-for-peyronie-s-disease-results-from-a-multi-center-single-arm-study
#9
Andrea Cocci, Giorgio Ivan Russo, Andrea Salonia, Gianmartin Cito, Federica Regis, Gaia Polloni, Gianluca Giubilei, Giovanni Cacciamani, Marco Capece, Marco Falcone, Isabella Greco, Massimiliano Timpano, Andrea Minervini, Mauro Gacci, Tommaso Cai, Giulio Garaffa, Bruno Giammusso, Davide Arcaniolo, Vincenzo Mirone, Nicola Mondaini
BACKGROUND: Collagenase Clostridium histolyticum (CCH; Xiapex) injections represent the only licensed medical treatment for Peyronie's disease (PD). AIM: To evaluate the efficacy and safety of CCH injections in men with stable PD, using a modified treatment protocol and to assess partners' bother improvement in a large cohort of White-European sexually active heterosexual men treated in a single tertiary-referral center. METHODS: All the 135 patients enrolled underwent a thorough assessment, which included history taking, physical examination, and pharmacologically induced artificial erection test (intra-cavernous injection) to assess the degree of penile curvature (PC) at baseline and after the completion of the treatment...
May 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29599391/dupuytren-treatment-effectiveness-trial-detect-a-protocol-for-prospective-randomised-controlled-outcome-assessor-blinded-three-armed-parallel-1-1-1-multicentre-trial-comparing-the-effectiveness-and-cost-of-collagenase-clostridium-histolyticum-percutaneous-needle
#10
Mikko P Räisänen, Teemu Karjalainen, Harry Göransson, Aleksi Reito, Hannu Kautiainen, Antti Malmivaara, Olli V Leppänen
INTRODUCTION: Dupuytren's contracture (DC) is a chronic fibroproliferative disorder of the palmar fascia which leads to flexion contracture in one or more fingers. There is no definitive cure for DC, and treatment aims at relieving symptoms by releasing the contracture using percutaneous or operative techniques. METHODS AND ANALYSIS: We planned a prospective, randomised, controlled, outcome assessor-blinded, three-armed parallel 1:1:1, multicentre trial comparing the effectiveness and cost of (1) collagenase clostridium histolyticum injection followed by limited fasciectomy in non-responsive cases, (2) percutaneous needle fasciotomy followed by limited fasciectomy in non-responsive cases and (3) primary limited fasciectomy during short-term and long-term follow-up for Tubiana I-III stages DC...
March 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29570549/skin-laceration-in-collagenase-clostridium-histolyticum-treatment-for-dupuytren-s-contracture
#11
Rafael Sanjuan-Cervero, Francisco J Carrera-Hueso, Salvador Oliver-Mengual, Maria A Ramon-Barrios, Clayton A Peimer, Narjis Fikri-Benbrahim
BACKGROUND: Dupuytren's contracture produces a progressive flexion contracture of the affected fingers. Collagenase Clostridium histolyticum produces breakdown of the cord in the hand and/or finger(s) that tightens as a result of the disease creating a contracture, allowing manual traction and cord rupture. One of the side effects is spontaneous skin laceration when the finger is extended. OBJECTIVES: To evaluate the development of skin lacerations in Dupuytren's contracture treated with collagenase Clostridium histolyticum, to determine predisposing factors, and evaluate the effectiveness of 2 different treatments (antiseptic and non-antiseptic dressings)...
March 2018: Orthopaedic Nursing
https://www.readbyqxmd.com/read/29560030/intralesional-collagenase-clostridium-histolyticum-in-the-management-of-peyronie-s-disease-current-best-practice
#12
REVIEW
Daniel J Cwikla, Faysal A Yafi
The use of Clostridium histolyticum collagenase (CCH) has become increasingly widespread for the treatment of Peyronie's disease (PD) in recent years. Numerous trials have confirmed both its safety and efficacy in appropriately selected patients with this condition. The purpose of this review is to examine pivotal trials demonstrating the efficacy of CCH, revisit viable candidates for treatment with intralesional injection therapy, and provide a summary of injection technique and appropriate management of patients receiving this treatment at the time of therapy and in follow up...
April 2018: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29535479/the-use-of-collagenase-clostridium-histolyticum-in-the-management-of-dupuytren-s-contracture-outcomes-of-a-pilot-study-in-a-district-general-hospital-setting
#13
Lynn E Murphy, Karen M Murphy, Shauneen M Kilpatrick, Neville W Thompson
Introduction: Collagenase Clostridium Histolyticum (CCH) is a recognised treatment option for adult patients presenting with Dupuytren's contracture (DC). Patients and Methods: Twenty male patients with established DC were treated using CCH. The average metacarpophalangeal (MCP) joint and proximal interphalangeal joint (PIP) contractures pre-treatment were 520 (range, 0 - 750 ) and 350 (range, 0 - 840 ) respectively. The average DASH score pre-treatment was 24.2 points (range, 0 - 68...
May 2017: Ulster Medical Journal
https://www.readbyqxmd.com/read/29519629/one-year-follow-up-after-treatment-with-cch-for-dupuytren-s-disease-a-prospective-view
#14
R Sanjuán-Cerveró, P Vazquez-Ferreiro, D Gómez-Herrero, F J Carrera-Hueso, N Fikri-Banbrahim
Aim Clostridium histolyticum collagenase (CCH) is nowadays an alternative treatment for the contracture of Dupuytren. Our objective is to assess its effectiveness at one year in a series of consecutive patients. MATERIAL AND METHOD: Prospective study with minimum follow-up of one year. Evaluation of results and adverse effects. RESULTS: A total of 75 joints treated in 51 patients were included. The average age was 65.18years (SD: 7.288) and 82.7% were males. The initial mean contraction of the MCP was 34...
March 5, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29444248/comparative-studies-on-the-activities-of-collagenases-from-grimontia-hollisae-and-clostridium-hystoliticum-in-the-hydrolysis-of-synthetic-substrates
#15
Teisuke Takita, Jun Qian, Hongmin Geng, Zejian He, Sho Nemoto, Mariko Mori, Keisuke Tanaka, Shunji Hattori, Kenji Kojima, Kiyoshi Yasukawa
The collagenase produced by a gram-negative bacterium Grimontia hollisae strain 1706B (Ghcol) degrades collagen more efficiently than that produced by a gram-positive bacterium Clostridium histolyticum (Chcol), which is currently the most widely used collagenase in industry [Teramura et al. (Cloning of a novel collagenase gene from the gram-negative bacterium Grimotia (Vibrio) hollisae 1706B and its efficient expression in Brevibacillus choshinensis. J Bacteriol 2011;193:3049-3056)]. Here, we compared the Ghcol and Chcol activities using two synthetic substrates...
May 1, 2018: Journal of Biochemistry
https://www.readbyqxmd.com/read/29414808/remineralization-potential-of-mints-containing-bioactive-agents-in-artificially-induced-root-caries
#16
Camila A Zamperini, Ana K Bedran-Russo
This study investigated the remineralization effect of experimental mint formulations containing bioactive agents (xylitol; green tea extract, GT; and amorphous calcium phosphate, ACP) in the progression of artificially induced root caries. Root caries lesions were induced by demineralization solution (pH 4.6; 96 h; 37°C). The lesions were treated with mint A, mint B, mint C, xylitol, GT, ACP, or remineralization solution (RS; negative control). Specimens were pH-cycled through treatments (5×/day; 3 min) and 6 cycles of acidic (pH 5...
February 8, 2018: Caries Research
https://www.readbyqxmd.com/read/29370792/what-do-we-know-about-managing-dupuytren-s-disease-cost-effectively
#17
Melina Dritsaki, Oliver Rivero-Arias, Alastair Gray, Catherine Ball, Jagdeep Nanchahal
BACKGROUND: Dupuytren's disease (DD) is a common and progressive, fibroproliferative disorder of the palmar and digital fascia of the hand. Various treatments have been recommended for advanced disease or to retard progression of early disease and to prevent deterioration of the finger contracture and quality of life. Recent studies have tried to evaluate the clinical and cost-effectiveness of therapies for DD, but there is currently no systematic assessment and appraisal of the economic evaluations...
January 25, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29317799/intra-articular-collagenase-injection-increases-range-of-motion-in-a-rat-knee-flexion-contracture-model
#18
Kayleigh Wong, Guy Trudel, Odette Laneuville
Objectives: A knee joint contracture, a loss in passive range of motion (ROM), can be caused by prolonged immobility. In a rat knee immobilization flexion contracture model, the posterior capsule was shown to contribute to an irreversible limitation in ROM, and collagen pathways were identified as differentially expressed over the development of a contracture. Collagenases purified from Clostridium histolyticum are currently prescribed to treat Dupuytren's and Peyronie's contractures due to their ability to degrade collagen...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29310171/re-clinical-experience-with-penile-traction-therapy-among-men-undergoing-collagenase-clostridium-histolyticum-for-peyronie-disease
#19
Allen F Morey
No abstract text is available yet for this article.
January 2018: Journal of Urology
https://www.readbyqxmd.com/read/29305454/efficacy-and-adverse-effects-of-collagenase-use-in-the-treatment-of-dupuytren-s-disease-a-meta-analysis
#20
R Sanjuan-Cerveró, F J Carrera-Hueso, P Vazquez-Ferreiro, M A Ramon-Barrios
AIMS: The aim of this meta-analysis was to assess the safety and efficacy of collagenase clostridium histolyticum compared with fasciectomy and percutaneous needle fasciotomy (PNF) for Dupuytren's disease. MATERIALS AND METHODS: We systematically searched PubMed, EMBASE, LILACS, Web of Science, Cochrane, Teseo and the ClinicalTrials.gov registry for clinical trials and cohort or case-control studies which compared the clinical outcomes and adverse effects of collagenase with those of fasciectomy or PNF...
January 2018: Bone & Joint Journal
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