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Atrial Fibrillation and Chemotherapy

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https://www.readbyqxmd.com/read/27909540/association-between-left-atrial-compression-and-atrial-fibrillation-a-case-presentation-and-a-short-review-of-literature
#1
Niloy Ahmed Md, Morales-Mangual Carlos Md, Gunsburg Moshe Md, Rosen Yitzhak Md
This case report describes a patient who developed palpitations and chest pain and was found to be in atrial fibrillation, which was likely due to the presence of an extra-cardiac mass. This was compressing the left atrium. The mass was related to small cell carcinoma, which decreased significantly in size after chemotherapy. Resolution of the atrial fibrillation correlated temporally with reduction in the size of the mass and alleviation of the left atrial compression.
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27902730/spectrum-of-cerebrovascular-disease-in-patients-with-multiple-myeloma-undergoing-chemotherapy-results-of-a-case-control-study
#2
Archana Hinduja, Kaustubh Limaye, Rahul Ravilla, Appalnaidu Sasapu, Xenofon Papanikolaou, Lai Wei, Michel Torbey, Sarah Waheed
OBJECTIVES: Patients with multiple myeloma (MM) are at increased risk of arterial thrombosis. Our aim was to determine the risk factors, mechanisms and outcome of strokes in these patients. METHODS: We conducted a retrospective matched case-control study from our database of MM patients enrolled in Total Therapy (TT) 2, TT3a and TT3b protocols who developed a vascular event (transient ischemic attack, ischemic stroke, or intracerebral hemorrhage) from October 1998 to January 2014...
2016: PloS One
https://www.readbyqxmd.com/read/27862097/phase-ib-trial-of-cabazitaxel-and-tasquinimod-in-men-with-heavily-pretreated-metastatic-castration-resistant-prostate-cancer-mcrpc-the-catch-trial
#3
Andrew J Armstrong, Michael S Humeniuk, Patrick Healy, Russell Szmulewitz, Carolyn Winters, Julie Kephart, Michael R Harrison, Elia Martinez, Kelly Mundy, Susan Halabi, Daniel George
BACKGROUND: Tasquinimod is an immunomodulating and anti-antiangiogenic oral agent with anti-prostate cancer activity in preclinical studies and in clinical trials of men with metastatic castration resistant prostate cancer (mCRPC), including single agent activity and in combination with taxanes. We sought to identify the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of tasquinimod in combination with cabazitaxel and prednisone in men with chemorefractory mCRPC. METHODS: Men with mCRPC who had failed prior docetaxel chemotherapy received cabazitaxel 25 mg/m(2) every 3 weeks with oral tasquinimod at 1 of 3 escalating dose levels (0...
November 16, 2016: Prostate
https://www.readbyqxmd.com/read/27812678/atrial-function-in-patients-with-breast-cancer-after-treatment-with-anthracyclines
#4
Yalin Tolga Yaylali, Ahmet Saricopur, Mustafa Yurtdas, Hande Senol, Gamze Gokoz-Dogu
Background: Atrial electromechanical delay (EMD) is used to predict atrial fibrillation, measured by echocardiography. Objectives: The aim of this study was to assess atrial EMD and mechanical function after anthracycline-containing chemotherapy. Methods: Fifty-three patients with breast cancer (48 ± 8 years old) who received 240 mg/m2of Adriamycin, 2400 mg/m2 of cyclophosphamide, and 960 mg/m2 of paclitaxel were included in this retrospective study, as were 42 healthy subjects (47 ± 9 years old)...
October 27, 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27780690/risk-of-atrial-fibrillation-and-bleeding-diathesis-associated-with-ibrutinib-treatment-a-systematic-review-and-pooled-analysis-of-four-randomized-controlled-trials
#5
Seongseok Yun, Nicole D Vincelette, Utkarsh Acharya, Ivo Abraham
BACKGROUND: Clinical trials raised concern that ibrutinib may increase the risk of atrial fibrillation/flutter (Afib/Aflutter) and major bleeding. However, the association has not been statistically validated, and there is no consensus regarding optimal management of anticoagulation among patients receiving ibrutinib who develop Afib/Aflutter. We performed a systematic review and pooled analysis to precisely assess the risk of Afib/Aflutter and bleeding associated with ibrutinib treatment in patients with hematologic malignancies...
September 19, 2016: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/27747019/cardiogenic-syncope-possibly-related-to-bevacizumab-containing-combination-chemotherapy-for-advanced-non-small-cell-lung-cancer
#6
Haruka Chino, Yosuke Amano, Yasuhiro Yamauchi, Jun Matsuda, Norihiko Takeda, Goh Tanaka, Daiya Takai, Takahide Nagase
We report the case of a 55-year-old man with stage IV lung adenocarcinoma who received carboplatin-paclitaxel-bevacizumab chemotherapy as second-line therapy. After four cycles of chemotherapy, he experienced syncope with a decrease in blood pressure. Electrocardiography (ECG) revealed atrial fibrillation. Cardiac ultrasonography showed a markedly reduced ejection fraction (45%), with moderate decrease in comparison to that before chemotherapy (66%). Bisoprolol fumarate was initiated, and the conversion to sinus rhythm was detected by ECG 4 days after the syncope...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27742069/b-cell-receptor-inhibition-as-a-target-for-cll-therapy
#7
Deepa Jeyakumar, Susan O'Brien
Inhibitors of the B cell receptor (BCR) represent an attractive therapeutic option for patients with chronic lymphocytic leukemia. Recently approved inhibitors of Bruton's tyrosine kinase (ibrutinib) and phosphatidylinositol 3-kinase (idelalisib), are promising agents because they are generally well tolerated and highly effective. These agents may be particularly important in the treatment of older patients who are less able to tolerate the myelosuppression (and infections) associated with chemoimmunotherapy...
March 2016: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/27638345/pneumatosis-intestinalis-during-chemotherapy-with-nilotinib-in-a-patient-with-chronic-myeloid-leukemia-who-tested-positive-for-anti-topoisomerase-i-antibodies
#8
Akihito Fujimi, Hiroki Sakamoto, Yuji Kanisawa, Shinya Minami, Yasuhiro Nagamachi, Naofumi Yamauchi, Soushi Ibata, Junji Kato
A 55-year-old man with several comorbidities including idiopathic interstitial pneumonia under long-term corticosteroid therapy, longstanding myocardial infarction, chronic heart failure, paroxysmal atrial fibrillation, gastro-esophageal reflux disease, constipation, and history of paralytic ileus, was diagnosed with chronic myelogenous leukemia (CML) in the chronic phase. He also tested positive for anti-topoisomerase I antibodies without clinical diagnosis of any connective tissue disease, including systemic sclerosis...
December 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27600461/prognostic-significance-of-new-onset-atrial-fibrillation-in-patients-with-non-hodgkin-s-lymphoma-treated-with-anthracyclines
#9
Michitaka Amioka, Akinori Sairaku, Tetsuro Ochi, Takenori Okada, Hideki Asaoku, Taiichi Kyo, Yasuki Kihara
Cancer therapeutics-related cardiac dysfunction induced by anthracycline is highly problematic, and its early recognition is of importance. Atrial fibrillation (AF) is sometimes seen after anthracycline chemotherapy. We aimed to test whether new-onset AF predicts anthracycline-induced heart failure. We prospectively studied 249 lymphoma patients who received anthracyclines. The patients were followed up with a frequent electrocardiographic examination. Fifteen patients (6%) newly developed AF after the chemotherapy, and during a mean follow-up of 34 months, they had a higher incidence of acute heart failure (40% vs 3...
August 12, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27472258/atrial-fibrillation-and-chronic-kidney-disease-requiring-hemodialysis-does-warfarin-therapy-improve-the-risks-of-this-lethal-combination
#10
Lohit Garg, Charity Chen, David E Haines
INTRODUCTION: Warfarin therapy for stroke prevention is recommended for patients with AF, but its value in patients with chronic kidney disease on HD is unknown. METHODS: The anticoagulation regimens of patients with a prior history of AF hospitalized for initiation of chronic HD, and of patients receiving chronic HD who had a new diagnosis of AF between 2009 and 2012 were reviewed. Exclusions were renal transplant, peritoneal dialysis, rheumatic valve disease, prosthetic heart valve, GI bleeding, malignancy with chemotherapy in last 6months or still undergoing treatment, a history of AF ablation, a history of ICD implantation, or those receiving warfarin for non-AF indications...
November 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27452493/-a-case-of-synchronous-malignant-pheochromocytomas-in-bilateral-adrenal-glands
#11
Kimitsugu Usui, Terukazu Hirasawa, Masataka Kobayashi, Kouichi Shioi, Kazuki Kobayashi, Naoki Sakai, Sumio Noguchi, Yukio Tsuura
We present a case of synchronous malignant pheochromocytoma in bilateral adrenal glands. A 73- year-old man presented to our hospital with bilateral adrenal masses incidentally found during abdominal ultrasonography examination for an unrelated issue. The patient had a 30-year history of hypertension and paroxysmal atrial fibrillation. Computed tomography and magnetic resonance imaging showed heterogeneous tumors in bilateral adrenal glands and an enlarged para-aortic lymph node. Hormonal examinations revealed a high value of urinary catecholamines...
June 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27417995/rare-cause-of-atrial-fibrillation-a-thymic-mass
#12
Swati Vishwanathan, Pritam Tayshetye, Farshaad Bilimoria, Gene Finley
A 62-year-old African-American man admitted to the emergency room with chest pain and exertional dyspnoea. He was found to be in rapid atrial fibrillation with pulmonary oedema. A transoesophageal echocardiogram performed prior to cardioversion showed a depressed left ventricular function (ejection fraction 30%) and an extracardiac heterogeneous echodensity compressing the right atrium and the superior vena cava. CT of the chest confirmed an anterior mediastinal mass measuring 13.5×6.6×10.1 cm, exerting a mass effect on the right atrium with mediastinal and right hilar adenopathy...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27374466/infusion-of-a-non-hla-matched-ex-vivo-expanded-cord-blood-progenitor-cell-product-after-intensive-acute-myeloid-leukaemia-chemotherapy-a-phase-1-trial
#13
Colleen Delaney, Filippo Milano, Laura Cicconi, Megan Othus, Pamela S Becker, Vicky Sandhu, Ian Nicoud, Ann Dahlberg, Irwin D Bernstein, Frederick R Appelbaum, Elihu H Estey
BACKGROUND: The intensive chemotherapy regimens used to treat acute myeloid leukaemia routinely result in serious infections, largely due to prolonged neutropenia. We investigated the use of non-HLA-matched ex-vivo expanded cord blood progenitor cells to accelerate haemopoietic recovery and reduce infections after chemotherapy. METHODS: We enrolled patients with a diagnosis of acute myeloid leukaemia by WHO criteria and aged 18-70 years inclusive at our institution (Fred Hutchinson Cancer Research Center) into this phase 1 trial...
July 2016: Lancet Haematology
https://www.readbyqxmd.com/read/27327505/pathophysiology-of-cancer-therapy-provoked-atrial-fibrillation
#14
REVIEW
Wan-Li Cheng, Yu-Hsun Kao, Shih-Ann Chen, Yi-Jen Chen
Atrial fibrillation (AF) occurs with increased frequency in cancer patients, especially in patients who undergo surgery or chemotherapy. AF disturbs the prognosis of cancer patients and challenges therapeutic outcomes of cancer treatment. Elucidating the mechanisms of cancer-induced AF would help identify specific strategies for preventing AF occurrence. In addition to concurrent risk factors of cancer and AF, cancer surgery, side effects of anticancer agents, and cancer-associated immune responses play critical roles in the genesis of AF...
September 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27318046/the-next-frontier-of-office-based-inferior-vena-cava-filter-placement
#15
Ahmad Alsheekh, Anil Hingorani, Natalie Marks, Enrico Ascher
OBJECTIVE: There is an increasing number of procedures that traditionally were performed in the inpatient setting that are now becoming office-based procedures. These include peripheral endovascular procedures such as angiograms, angioplasties, dialysis access interventions, and treatment for venous insufficiency. We chose to evaluate the feasibility, safety of inferior vena cava (IVC) filter placement in the office-based setting. METHODS: All procedures were performed using local anesthesia, and ultrasound guidance for puncture...
July 2016: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/27148366/pericardial-metastasis-induced-tamponade-from-urothelial-carcinoma-a-rare-entity
#16
Rafay Khan, Waqas Jehangir, Sunil Tulpule, Mohamed Osman, Shilpi Singh, Shuvendu Sen
Urothelial carcinoma in a few cases may result in cardiac metastasis. A rare presentation of this condition is its diagnosis as a result of cardiac tamponade. Tamponade is an unusual entity as a result of urothelial carcinoma and has only been reported in four cases. There have also been only a total of fifteen cases of cardiac metastasis from this form of malignancy. It is through this discussion that we emphasize the importance of early detection and monitoring of cardiac symptoms with the implementation of echocardiogram imaging...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27108362/arrhythmias-and-other-electrophysiology-issues-in-cancer-patients-receiving-chemotherapy-or-radiation
#17
REVIEW
Federico Viganego, Robin Singh, Michael G Fradley
Enhanced understanding of cancer biology has significantly increased treatment options and dramatically improved outcomes for patients with malignancies. Despite these advances, many therapies have cardiovascular toxicities which can affect morbidity and mortality independent of the oncologic prognosis. Arrhythmias and other electrophysiology issues are increasingly identified as common complications of cancer therapy. Atrial fibrillation and other supraventricular arrhythmias are frequently observed in cancer patients receiving chemotherapy, often due to their effects on intracellular signaling pathways...
June 2016: Current Cardiology Reports
https://www.readbyqxmd.com/read/26995987/-immediate-results-of-isolated-chemoperfusion-of-the-lung-with-melphalan-and-cisplatin-in-combination-with-metastasectomy-in-treatment-for-resectable-metastatic-lung-lesions
#18
E V Levchenko, P S Kalinin, K Yu Senchik, O Yu Mamontov, L V Gorokhov, A S Barchuk, A V Mishchenko
For treatment of metastatic lung lesions there was used the method of isolated chemoperfusion in combination with metastasectomy. The study included 74 patients (mean age 43 ± 13.4 years). There were performed 99 normothermic isolated chemoperfusions of the lung: with melphalan (39) and cisplatin (60). During surgery there were no lethality outcomes. In the immediate postoperative period it was recorded 1 (1.4%) death developed in 3 days after surgery. The cause of this death was postperfusion lung edema accompanied by increase of signs of respiratory insufficiency...
2015: Voprosy Onkologii
https://www.readbyqxmd.com/read/26984081/reversible-atrial-fibrillation-with-bradycardia-associated-with-primary-cardiac-b-cell-lymphoma
#19
Keiichi Hishikari, Taishi Kuwahara, Shigeki Kimura, Hiroyuki Hikita, Atsushi Takahashi, Mitsuaki Isobe
Primary cardiac lymphoma (PCL) only rarely occurs and it is defined as a lymphoma in which the bulk of the tumor is located within the heart and pericardium. A 53-year-old woman was referred due to dyspnea, and an electrocardiogram exhibited atrial fibrillation (AF). Echocardiography revealed no abnormal findings. Scintigraphy and a lymph node biopsy led to a diagnosis of PCL. After the start of chemotherapy, AF was converted to atrial tachycardia prior to sinus rhythm with a first-degree atrioventricular block, which was finally restored to a normal sinus rhythm...
2016: Internal Medicine
https://www.readbyqxmd.com/read/26640039/ibrutinib-in-combination-with-rituximab-in-relapsed-or-refractory-mantle-cell-lymphoma-a-single-centre-open-label-phase-2-trial
#20
Michael L Wang, Hun Lee, Hubert Chuang, Nicolaus Wagner-Bartak, Frederick Hagemeister, Jason Westin, Luis Fayad, Felipe Samaniego, Francesco Turturro, Yasuhiro Oki, Wendy Chen, Maria Badillo, Krystle Nomie, Maria DeLa Rosa, Donglu Zhao, Laura Lam, Alicia Addison, Hui Zhang, Ken H Young, Shaoying Li, David Santos, L Jeffrey Medeiros, Richard Champlin, Jorge Romaguera, Leo Zhang
BACKGROUND: Ibrutinib is approved in the EU, USA, and other countries for patients with mantle cell lymphoma who received one previous therapy. In a previous phase 2 study with single-agent ibrutinib, the proportion of patients who achieved an objective response was 68%; 38 (34%) of 111 patients had transient lymphocytosis. We hypothesised that adding rituximab could target mantle cell lymphoma cells associated with redistribution lymphocytosis, leading to more potent antitumour activity...
January 2016: Lancet Oncology
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