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Cardiac Radiotherapy

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https://www.readbyqxmd.com/read/27906782/predicting-heart-dose-in-breast-cancer-patients-who-received-3d-conformal-radiation-therapy
#1
Daniel Wollschläger, Heiko Karle, Marcus Stockinger, Detlef Bartkowiak, Sandra Bührdel, Hiltrud Merzenich, Thomas Wiegel, Heinz Schmidberger, Maria Blettner
Cardiac late effects are a major health concern for long-term survivors after radiotherapy for breast cancer. Large cohort studies to better understand the exact dose-response relationship require individual estimates of radiation dose to the heart. To predict individual cardiac dose from information that is typically available for all members of a retrospective epidemiological cohort study, 774 female breast cancer patients treated with megavoltage tangential field radiotherapy in 1998-2008 were examined. All dose distributions were calculated using Eclipse with the anisotropic analytical algorithm (AAA) for photon fields and the electron Monte Carlo algorithm for electron boost fields...
January 2017: Health Physics
https://www.readbyqxmd.com/read/27891443/a-randomized-prospective-study-of-concurrent-chemo-radiotherapy-vs-accelerated-hyperfractionation-in-advanced-cancer-of-head-and-neck
#2
Himanshu Mishra, Ritusha Mishra, Uday Prataap Shahi, Abhijit Mandal
INTRODUCTION: Locally advanced unresectable squamous cell carcinoma of head and neck has poor locoregional control when treated with conventionally fractionated Radiation Therapy (RT) alone. However, Concurrent Chemo-Radiotherapy (CRT) and altered fractionated RT schedules like Accelerated Hyperfractionation (AHF) are two different treatment strategies that have shown to be associated with better efficacy as compared to conventional RT alone in such cases. AIM: Aim of the study was to compare these two treatment strategies i...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890346/the-uk-heartspare-study-stage-ii-multicentre-evaluation-of-a-voluntary-breath-hold-technique-in-patients-receiving-breast-radiotherapy
#3
F R Bartlett, E M Donovan, H A McNair, L A Corsini, R M Colgan, P M Evans, L Maynard, C Griffin, J S Haviland, J R Yarnold, A M Kirby
AIMS: To evaluate the feasibility and heart-sparing ability of the voluntary breath-hold (VBH) technique in a multicentre setting. MATERIALS AND METHODS: Patients were recruited from 10 UK centres. Following surgery for early left breast cancer, patients with any heart inside the 50% isodose from a standard free-breathing tangential field treatment plan underwent a second planning computed tomography (CT) scan using the VBH technique. A separate treatment plan was prepared on the VBH CT scan and used for treatment...
November 24, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27881295/measuring-dose-from-radiotherapy-treatments-in-the-vicinity-of-a-cardiac-pacemaker
#4
Samuel C Peet, Rachael Wilks, Tanya Kairn, Scott B Crowe
This study investigated the dose absorbed by tissues surrounding artificial cardiac pacemakers during external beam radiotherapy procedures. The usefulness of out-of-field reference data, treatment planning systems, and skin dose measurements to estimate the dose in the vicinity of a pacemaker was also examined. Measurements were performed by installing a pacemaker onto an anthropomorphic phantom, and using radiochromic film and optically stimulated luminescence dosimeters to measure the dose in the vicinity of the device during the delivery of square fields and clinical treatment plans...
November 21, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27881015/predictors-of-survival-in-patients-with-brain-metastases-from-gastric-cancer
#5
D Rades, T Bartscht, S E Schild
This study aims to identify predictors of survival and contribute to treatment personalization in patients with brain metastases from gastric cancer. Twelve patients received whole-brain radiotherapy (WBRT), four stereotactic radiosurgery and six neurosurgery plus WBRT. Treatment regimen, age, gender, Eastern Cooperative Oncology Group (ECOG) performance score, tumor site, number of brain metastases, extra-cranial metastases and interval between cancer diagnosis and brain metastases were evaluated for survival...
November 24, 2016: Neoplasma
https://www.readbyqxmd.com/read/27873127/radiotherapy-induced-global-and-regional-differences-in-early-stage-left-sided-versus-right-sided-breast-cancer-patients-speckle-tracking-echocardiography-study
#6
Suvi Sirkku Tuohinen, Tanja Skyttä, Tuija Poutanen, Heini Huhtala, Vesa Virtanen, Pirkko-Liisa Kellokumpu-Lehtinen, Pekka Raatikainen
Radiotherapy (RT) to the thoracic region increases late cardiovascular morbidity and mortality. The impact of breast cancer laterality on cardiac function is largely unknown. The aim of this prospective study was to compare RT-induced changes in left-sided and right-sided breast cancer patients using speckle tracking echocardiography (STE). Sixty eligible patients with left-sided breast cancer and 20 with right-sided breast cancer without chemotherapy were evaluated prospectively before and early after RT. A comprehensive echocardiographic examination included three dimensional measurements and STE of the left ventricle (LV)...
November 21, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27867461/transesophageal-echocardiography-and-radiation-induced-damages
#7
Marzia Cottini, Vincenzo Polizzi, Paolo Giuseppe Pino, Vitaliano Buffa, Francesco Musumeci
The long-term sequelae of mantle therapy include, especially lung and cardiac disease but also involve the vessels and the organs in the neck and thorax (such as thyroid, aorta, and esophagus). We presented the case of 66-year-old female admitted for congestive heart failure in radiation-induced heart disease. The patient had undergone to massive radiotherapy 42 years ago for Hodgkin's disease (type 1A). Transesophageal echocardiography was performed unsuccessfully with difficulty because of the rigidity and impedance of esophageal walls...
July 2016: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/27866063/anticancer-therapy-induced-vascular-toxicity-vegf-inhibition-and-beyond
#8
REVIEW
Daniela Di Lisi, Rosalinda Madonna, Concetta Zito, Enrico Bronte, Giuseppe Badalamenti, Paolo Parrella, Ines Monte, Carlo Gabriele Tocchetti, Antonio Russo, Giuseppina Novo
Cardiotoxicity induced by chemotherapeutic agents and radiotherapy is a growing problem. In recent years, an increasing number of new drugs with targeted action have been designed. These molecules, such as monoclonal antibodies and tyrosine kinase inhibitors, can cause different type of toxicities compared to traditional chemotherapy. However, they can also cause cardiac complications such as heart failure, arterial hypertension, QT interval prolongation and arrhythmias. Currently, a field of intense research is the vascular toxicity induced by new biologic drugs, particularly those which inhibit vascular endothelial growth factor (VEGF) and its receptor (VEGF-R) and other tyrosine kinases...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27858317/trends-in-cardiac-mortality-in-women-with-ductal-carcinoma-in-situ
#9
Waqar Haque, Vivek Verma, Anam Haque, E Brian Butler, Bin S Teh
PURPOSE: In certain ductal carcinoma in situ (DCIS) subpopulations, there is no consensus regarding whether to postoperatively irradiate; decisions are often made based on potential risk of cardiac toxicities. Given the utility of Surveillance, Epidemiology, and End Results (SEER) data for studying cardiac mortality in invasive disease, this is the first such study specific for DCIS patients, evaluating trends in cardiac mortality after left-sided radiotherapy (RT). METHODS: The SEER database was queried for patients with DCIS that received RT and had known unilaterality...
November 17, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27846658/late-effects-following-treatment-of-hodgkin-lymphoma-during-childhood-and-adolescence-results-of-the-hodgkin-lymphoma-late-effects-research-project
#10
W Dörffel, M Riepenhausen, H Lüders, J Brämswig
Survival rates have been excellent in patients treated for Hodgkin lymphoma (HL) during childhood and adolescence. Unfortunately, severe treatment related late effects have been observed. It was therefore an important aim of the cooperative pediatric HL therapy studies in Germany to reduce the number of late effects without jeopardizing the excellent treatment results. Progress and relapses of HL were analyzed to obtain important information for the future salvage therapy. All late effects were documented and their etiologies analyzed...
November 2016: Klinische Pädiatrie
https://www.readbyqxmd.com/read/27842711/-radiation-related-heart-toxicity-update-in-women
#11
S Marlière, E Vautrin, C Saunier, A Chaikh, I Gabelle-Flandin
Breast cancer is a common diagnosis in women and thus women are at risk of radiation-induced heart disease, in particular during radiotherapy for left breast cancer and when the internal mammary chain is included. Rates of major cardiac events increase with younger age at the time of irradiation, diagnosis before 1990s, higher radiation doses, coexisting cardiovascular risk factors and adjuvant cardiotoxic chemotherapy. Radiation-induced heart disease comprises a spectrum of cardiac pathologies, including pericardial disease, cardiomyopathy, coronary artery disease and valvular disease...
December 2016: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/27823600/radiotherapy-induced-cardiac-implantable-electronic-device-dysfunction-in-patients-with-cancer
#12
Rodrigo Bagur, Mathilde Chamula, Émilie Brouillard, Caroline Lavoie, Luis Nombela-Franco, Anne-Sophie Julien, Louis Archambault, Nicolas Varfalvy, Valérie Gaudreault, Sébastien X Joncas, Zeev Israeli, Yasir Parviz, Mamas A Mamas, Shahar Lavi
Radiotherapy can affect the electronic components of a cardiac implantable electronic device (CIED) resulting in malfunction and/or damage. We sought to assess the incidence, predictors, and clinical impact of CIED dysfunction (CIED-D) after radiotherapy for cancer treatment. Clinical characteristics, cancer, different types of CIEDs, and radiation dose were evaluated. The investigation identified 230 patients, mean age 78 ± 8 years and 70% were men. A total of 199 patients had pacemakers (59% dual chamber), 21 (9%) cardioverter-defibrillators, and 10 (4%) resynchronizators or defibrillators...
October 7, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27805817/the-role-of-tgf-beta-and-ppar-alpha-signalling-pathways-in-radiation-response-of-locally-exposed-heart-integrated-global-transcriptomics-and-proteomics-analysis
#13
Vikram Subramanian, Ingar Seemann, Juliane Merl-Pham, Stefanie M Hauck, Fiona Anne Stewart, Michael J Atkinson, Soile Tapio, Omid Azimzadeh
Epidemiological data from patients undergoing radiotherapy for thoracic tumours clearly show the damaging effect of ionising radiation on cardiovascular system. The long-term impairment of heart function and structure after local high-dose irradiation is associated with systemic inflammatory response, contraction impairment, microvascular damage and cardiac fibrosis. The goal of the present study was to investigate molecular mechanisms involved in this process. C57BL/6J mice received a single X-ray dose of 16 Gy given locally to the heart at the age of 8 weeks...
November 2, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27804053/3d-conformal-radiotherapy-is-not-associated-with-the-long-term-cardiac-mortality-in-breast-cancer-patients-a-retrospective-cohort-study-in-germany-passos-heart-study
#14
Hiltrud Merzenich, Detlef Bartkowiak, Heinz Schmidberger, Marcus Schmidt, Lukas Schwentner, Thomas Wiegel, Achim Woeckel, Daniel Wollschläger, Maria Blettner
PURPOSE: In breast cancer patients treated in the 1970s and 1980s, radiation therapy (RT) for left-sided tumors has been associated with an elevated risk of cardiac mortality. In recent years, improved RT techniques have reduced radiation exposure of the heart and major coronary vessels, but some exposure remains unavoidable. In a retrospective cohort study, we investigated the long-term cardiac mortality risk of breast cancer survivors treated with modern RT in Germany. METHODS: A total of 11,982 women were included who were treated for breast cancer between 1998 and 2008...
November 1, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27779127/towards-real-time-mri-guided-3d-localization-of-deforming-targets-for-non-invasive-cardiac-radiosurgery
#15
S Ipsen, O Blanck, N J Lowther, G P Liney, R Rai, F Bode, J Dunst, A Schweikard, P J Keall
Radiosurgery to the pulmonary vein antrum in the left atrium (LA) has recently been proposed for non-invasive treatment of atrial fibrillation (AF). Precise real-time target localization during treatment is necessary due to complex respiratory and cardiac motion and high radiation doses. To determine the 3D position of the LA for motion compensation during radiosurgery, a tracking method based on orthogonal real-time MRI planes was developed for AF treatments with an MRI-guided radiotherapy system. Four healthy volunteers underwent cardiac MRI of the LA...
November 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27762625/implantable-cardioverter-defibrillator-management-an-update
#16
Michele Malagù, Alessandra Ferri, Ottavia Mancuso, Filippo Trevisan, Marianna Nardozza, Matteo Bertini
Implantable cardioverter defibrillator (ICD) is the cornerstone of primary and secondary prevention of sudden cardiac death. In 35 years of technologic improvement and clinical trials, there has been a continuous increase in implantation rate. Purpose of this review is to point out and discuss every aspect related to actual ICD management, investigating implantation procedure and predischarge care, office and remote monitoring follow-up, diagnostic evaluations, management of patients with suspected therapies or malfunctions, heart failure, surgery, radiotherapy and endoscopic procedures...
October 20, 2016: Future Cardiology
https://www.readbyqxmd.com/read/27741117/radiation-induced-heart-disease-in-lung-cancer-radiotherapy-a-dosimetric-update
#17
Xin Ming, Yuanming Feng, Chengwen Yang, Wei Wang, Ping Wang, Jun Deng
BACKGROUND: Radiation-induced heart disease (RIHD), which affects the patients' prognosis with both acute and late side effects, has been published extensively in the radiotherapy of breast cancer, lymphoma and other benign diseases. Studies on RIHD in lung cancer radiotherapy, however, are less extensive and clear even though the patients with lung cancer are delivered with higher doses to the heart during radiation treatment. METHODS: In this article, after extensive literature search and analysis, we reviewed the current evidence on RIHD in lung cancer patients after their radiation treatments and investigated the potential risk factors for RIHD as compared to other types of cancers...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27716875/advantage-of-deep-inspiration-breath-hold-in-left-sided-breast-cancer-patients-treated-with-3d-conformal-radiotherapy
#18
Luciana Lastrucci, Simona Borghesi, Silvia Bertocci, Chiara Gasperi, Andrea Rampini, Giovanna Buonfrate, Paola Pernici, Roberta De Majo, Pietro Giovanni Gennari
PURPOSE: To compare 3D-conformal radiotherapy (3D-CRT) treatment plans based on free-breathing (FB) and deep inspiration breath hold (DIBH) and investigated whether DIBH technique enables a decrease of cardiac left anterior descending coronary artery (LADCA) and lungs dose with respect to the FB. METHODS: Twenty-three left-sided breast cancer patients referred for breast radiotherapy were included. The planning target volume (PTV) encompassed the breast and organs at risk including heart, LADCA, lungs, and contralateral breast, which were contoured in FB and DIBH CT scans...
September 27, 2016: Tumori
https://www.readbyqxmd.com/read/27681376/prospective-study-of-postoperative-whole-breast-radiotherapy-for-japanese-large-breasted-women-a-clinical-and-dosimetric-comparisons-between-supine-and-prone-positions-and-a-dose-measurement-using-a-breast-phantom
#19
Kana Takahashi, Madoka Morota, Yoshikazu Kagami, Hiroyuki Okamoto, Shuhei Sekii, Koji Inaba, Naoya Murakami, Hiroshi Igaki, Yoshinori Ito, Takashi Uno, Jun Itami
BACKGROUND: This prospective study aimed to compare dose volume histograms (DVH) of the breasts and organs at risk (OARs) of whole breast radiotherapy in the supine and prone positions, and frequency and severity of acute and late toxicities were analyzed. METHODS: Early-stage breast cancer patients with large breasts (Japanese bra size C or larger, or the widest measurements of the bust ≥ 95 cm) undergoing partial mastectomy participated in this study. CT-based treatment plans were made in each position, and various dosimetric parameters for the breast and OARs were calculated to compare the supine and prone radiotherapy plans...
September 29, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27659357/usefulness-of-chemoradiotherapy-for-inoperable-gastric-cancer
#20
T Taki, Y Hoya, A Watanabe, T Nakayoshi, T Okamoto, H Sekine, N Mitsumori, K Yanaga
Introduction Radiotherapy is not commonly used for the treatment of gastric cancer in Japan, where surgery is the standard local treatment. We report the results of chemoradiotherapy in patients with advanced or recurrent gastric cancer which was deemed difficult to treat surgically. Methods Twenty-one patients with gastric cancer (including sixteen with advanced/recurrent gastric cancer and five with poor general condition) underwent chemo-radiotherapy, for whom the therapeutic efficacy, toxicity and survival period were analysed...
September 23, 2016: Annals of the Royal College of Surgeons of England
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