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Cardiac Radiotherapy

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https://www.readbyqxmd.com/read/29670854/deep-inspiration-breath-hold-techniques-and-advantages-for-cardiac-sparing-during-breast-cancer-irradiation
#1
REVIEW
Carmen Bergom, Adam Currey, Nina Desai, An Tai, Jonathan B Strauss
Historically, heart dose from left-sided breast radiotherapy has been associated with a risk of cardiac injury. Data suggests that there is not a threshold for the deleterious effects from radiation on the heart. Over the past several years, advances in radiation delivery techniques have reduced cardiac morbidity due to treatment. Deep inspiration breath hold (DIBH) is a technique that takes advantage of a more favorable position of the heart during inspiration to minimize heart doses over a course of radiation therapy...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29667046/radiotherapy-in-patients-with-cardiac-implantable-electronic-devices-clinical-and-dosimetric-aspects
#2
Giulia Riva, Ombretta Alessandro, Ruggero Spoto, Annamaria Ferrari, Cristina Garibaldi, Federica Cattani, Rosa Luraschi, Elena Rondi, Nicola Colombo, Fulvio Lorenzo Francesco Giovenzana, Carlo Maria Cipolla, Mikolaj Winnicki, Martina Persiani, Fabiana Castelluccia, Massimo Sarra Fiore, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
As a result of aging, the number of patients with cardiac implantable electronic device (CIED) requiring radiotherapy (RT) continues to rise. The aim of this work was to evaluate RT-related malfunctions of CIED in a cohort of patients who underwent RT in our clinic from June 2010 to December 2016. We retrospectively analyzed 93 RT treatments in 63 patients with CIEDs. Patients were treated with 3D conformal RT, intensity-modulated RT and stereotactic RT. We collected clinical characteristics of cancer, models of CIEDs, total RT dose to tumor and radiation energy...
April 17, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29659977/quantification-of-variation-in-dose-volume-parameters-for-the-heart-pericardium-and-left-ventricular-myocardium-during-thoracic-tumor-radiotherapy
#3
Ying Tong, Yong Yin, Pinjing Cheng, Jie Lu, Tonghai Liu, Jinhu Chen, Guanzhong Gong
Cardiac activity can induce dose-volume evaluation errors for cardiac structures. The purpose of this study was to quantify the variation in dose-volume parameters for the heart, pericardium and left ventricular myocardium (LVM) throughout the cardiac circle. The heart, pericardium and LVM of 22 patients were contoured on 20 phases of electrocardiography-gated 4D computed tomography (4DCT) images acquired during breath-hold. Radiotherapy plans were designed on 0% phase of the 4DCT images, and the dose distributions of the plans were imported into MIM Maestro and deformed to each phase to generate distributions for all phases...
April 5, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29651533/spatial-orientation-of-coronary-arteries-and-its-implication-for-breast-and-thoracic-radiotherapy-proposing-coronary-strip-as-a-new-organ-at-risk
#4
Anusheel Munshi, Nilaxi Khataniar, Biplab Sarkar, Moti Lal Bera, Bidhu Kalyan Mohanti
OBJECTIVES: Radiotherapy for breast cancer has been associated with various side effects including cardiac sequelae. Our study aimed to define the spatial arc of spread of coronary vessels in a radian angle. MATERIALS AND METHODS: We analysed the records of 51 CT coronary angiographies done in our hospital from January 2016 to July 2016. Left anterior descending (LAD) and right coronary (RC) were contoured for each patient. In each axial section, the radial spread of each artery was noted...
April 12, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29650363/chemotherapy-versus-chemoradiotherapy-after-surgery-and-preoperative-chemotherapy-for-resectable-gastric-cancer-critics-an-international-open-label-randomised-phase-3-trial
#5
Annemieke Cats, Edwin P M Jansen, Nicole C T van Grieken, Karolina Sikorska, Pehr Lind, Marianne Nordsmark, Elma Meershoek-Klein Kranenbarg, Henk Boot, Anouk K Trip, H A Maurits Swellengrebel, Hanneke W M van Laarhoven, Hein Putter, Johanna W van Sandick, Mark I van Berge Henegouwen, Henk H Hartgrink, Harm van Tinteren, Cornelis J H van de Velde, Marcel Verheij
BACKGROUND: Both perioperative chemotherapy and postoperative chemoradiotherapy improve survival in patients with resectable gastric cancer from Europe and North America. To our knowledge, these treatment strategies have not been investigated in a head to head comparison. We aimed to compare perioperative chemotherapy with preoperative chemotherapy and postoperative chemoradiotherapy in patients with resectable gastric adenocarcinoma. METHODS: In this investigator-initiated, open-label, randomised phase 3 trial, we enrolled patients aged 18 years or older who had stage IB- IVA resectable gastric or gastro-oesophageal adenocarcinoma (as defined by the American Joint Committee on Cancer, sixth edition), with a WHO performance status of 0 or 1, and adequate cardiac, bone marrow, liver, and kidney function...
April 9, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29617509/a-rare-cause-of-abdominal-pain-in-childhood-cardiac-angiosarcoma
#6
Elvan Caglar Citak, Murat Ozeren, M Kerem Karaca, Derya Karpuz, Feryal Karahan, Eda Bengi Yilmaz, Yuksel Balci, Pelin Ozcan Kara, Rabia Bozdogan Arpaci
Cardiac angiosarcomas are extremely rare in childhood, they are rapidly progressive tumours that often present themselves as diagnostic dilemmas, resulting in delayed diagnosis. Also, extracardiac manifestations, including abdominal pain, are extremely rare in patients with intracardiac tumors. We herein present the case of a 15-year-old girl who presented with abdominal pain. Echocardiography and thoracic computed tomography showed right atrial mass. The patient underwent surgery, chemotherapy, and radiotherapy...
January 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29615371/intraluminal-brachytherapy-boost-following-external-beam-radiotherapy-with-concurrent-chemotherapy-of-oesophagus-carcinoma-results-of-a-prospective-observational-study
#7
P Nag, O P Gurjar, V Bhandari, K L Gupta, P Bagdare, H Goyal
PURPOSE: The main objective of our study is to evaluate response and toxicity profile in patients receiving external beam radiotherapy with concurrent chemotherapy followed by intraluminal brachytherapy boost for a carcinoma of the oesophagus. MATERIAL AND METHODS: Twenty patients with biopsy-proven carcinoma of the oesophagus received external beam radiotherapy (50Gy in 25 fractions) with concurrent chemotherapy (cisplatin: 40mg/m2 ). After a gap of two to three weeks, intraluminal brachytherapy (10Gy in two fractions each 1 week apart by a high dose rate60 Co source) was given...
March 31, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29611048/use-of-speckle-tracking-in-the-evaluation-of-late-subclinical-myocardial-damage-in-survivors-of-childhood-acute-leukaemia
#8
Elena Guadalupe Corella Aznar, Ariadna Ayerza Casas, Lorenzo Jiménez Montañés, Maria Ángeles Carlota Calvo Escribano, José Ignacio Labarta Aizpún, Pilar Samper Villagrasa
Heart disease is the leading cause of non-cancer death in childhood cancer survivors. to determine the prevalence of subclinical cardiac dysfunction using speckle tracking and compare its results with those obtained by classical methods of assessing left ventricular function and its relationship with different factors to identify the population at higher risk. Echocardiographic assessment of left ventricular function included ejection fraction, tissue Doppler, longitudinal/circumferential strains and biochemical parameters (troponin-T and Pro-BNP) in a cohort of 57 survivors of childhood acute leukaemia with at least 10 years since diagnosis...
April 2, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29609845/evolution-of-brachytherapy-treatment-planning-to-deterministic-radiation-transport-for-calculation-of-cardiac-dose
#9
REVIEW
Peter A Sandwall, Yuntao Feng, Michael Platt, Michael Lamba, Sudha Mahalingam
Brachytherapy was among the first methods of radiotherapy and has steadily continued to evolve. Here we present a brief review of the progression of dose calculation methods in brachytherapy to the current state-of-the art computerized methods for heterogeneity correction. We further review the origin and development of the BrachyVision (Varian Medical Systems, Inc., Palo Alto, CA) treatment planning system and evaluate dosimetric results from 12 patients implanted with the strut-assisted volumetric implant (SAVI) applicator (Cianna Medical, Aliso Viejo, CA) for accelerated partial breast irradiation (APBI)...
March 30, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29605120/assessment-of-deep-inspiration-breath-hold-dibh-amplitude-and-reduction-in-cardiac-dose-in-left-breast-cancer-patients
#10
D Ledsom, A J Reilly, H Probst
INTRODUCTION: The primary aim of this study was to examine the impact of deep inspiration breath-hold (DIBH) amplitude on subsequent mean heart dose and V30 during radiotherapy. The secondary aim was to investigate if patient age influenced DIBH amplitude. METHOD: A retrospective study of 30 patients with left-sided breast cancer was completed. Patients were randomly selected from the total number of patients dual scanned in free breathing (FB) and DIBH over a 2-year period...
May 2018: Radiography
https://www.readbyqxmd.com/read/29599341/radiotherapy-induced-early-ecg-changes-and-their-comparison-with-echocardiography-in-patients-with-early-stage-breast-cancer
#11
Suvi Sirkku Tuohinen, Konsta Keski-Pukkila, Tanja Skyttä, Heini Huhtala, Vesa Virtanen, Pirkko-Liisa Kellokumpu-Lehtinen, Pekka Raatikainen, Kjell Nikus
BACKGROUND: Early electrocardiogram (ECG) changes after breast cancer radiotherapy (RT) have been reported, but their characteristics and associated factors are largely unknown. This study aimed to explore early RT-induced ECG changes and to compare them with echocardiography changes. MATERIALS AND METHODS: Sixty eligible patients with chemotherapy-naïve left-sided and 20 with right-sided breast cancer were evaluated with echocardiography, blood samples and ECG before and after RT...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29596556/uveal-melanoma-associated-with-myotonic-dystrophy-a-report-of-6-cases
#12
Lauren A Dalvin, Carol L Shields, Jose S Pulido, Kareem Sioufi, Victoria Cohen, Jerry A Shields
Importance: Patients with myotonic dystrophy (MD) have an increased risk of malignancy including uveal melanoma. This case series further explores the association between these 2 diseases. Objective: To describe a cohort of patients with uveal melanoma associated with MD, including a case of iris melanoma, and MD-associated uveal melanoma in relatives. Design, Setting, and Participants: Retrospective case series at 3 tertiary referral centers (Wills Eye Hospital, Philadelphia, Pennsylvania; Mayo Clinic, Rochester, Minnesota; and Moorsfields Eye Hospital, London, England), between January 1, 2000, and August 31, 2017...
March 29, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29595699/severe-bilateral-isolated-coronary-ostial-lesions-as-a-rare-manifestation-of-radiation-induced-cardiac-disease-a-case-report
#13
Metesh Nalin Acharya, Mohammad El-Diasty, Bastian Schmack, Alexander Weymann, Ashham Mansur, Aron-Frederik Popov
RATIONALE: With advances in contemporary radiotherapy techniques, and as cancer survival improves, severe isolated coronary ostial disease may develop many years following mediastinal radiotherapy, even in the absence of classical cardiovascular risk factors. PATIENT CONCERNS: We describe the case of a 73-year-old woman with previous chest radiotherapy for breast cancer who underwent coronary artery bypass graft surgery for severe bilateral coronary ostial lesions...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29556748/radiation-induced-cardiovascular-toxicity-mechanisms-prevention-and-treatment
#14
REVIEW
Johan Spetz, Javid Moslehi, Kristopher Sarosiek
PURPOSE OF REVIEW: Ionizing radiation is a highly effective treatment for a wide range of malignancies, yet the cardiovascular (CV) toxicity that can result from chest radiotherapy impairs the long-term health of cancer survivors and can be a limiting factor for its use. Despite over 100 years of successful clinical use, the mechanisms by which high-energy photons damage critical components within cells of the heart's myocardium, pericardium, vasculature, and valves remain unclear. RECENT FINDINGS: Recent studies exploring the acute and chronic effects of radiation therapy on cardiac and vascular tissue have provided new insights into the development and progression of heart disease, including the identification and understanding of age- and complication-associated risk factors...
March 20, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29520213/voluntary-deep-inspiration-breath-hold-reduces-the-heart-dose-without-compromising-the-target-volume-coverage-during-radiotherapy-for-left-sided-breast-cancer
#15
Noora Al-Hammadi, Palmira Caparrotti, Carole Naim, Jillian Hayes, Katherine Rebecca Benson, Ana Vasic, Hissa Al-Abdulla, Rabih Hammoud, Saju Divakar, Primoz Petric
Background: During radiotherapy of left-sided breast cancer, parts of the heart are irradiated, which may lead to late toxicity. We report on the experience of single institution with cardiac-sparing radiotherapy using voluntary deep inspiration breath hold (V-DIBH) and compare its dosimetric outcome with free breathing (FB) technique. Patients and methods: Left-sided breast cancer patients, treated at our department with postoperative radiotherapy of breast/chest wall +/- regional lymph nodes between May 2015 and January 2017, were considered for inclusion...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29497862/cardiovascular-concerns-in-brca1-and-brca2-mutation-carriers
#16
REVIEW
Kelly C Gast, Paul V Viscuse, Somaira Nowsheen, Tufia C Haddad, Robert W Mutter, Andrea E Wahner Hendrickson, Fergus J Couch, Kathryn J Ruddy
PURPOSE OF REVIEW: BRCA1 and BRCA2 mutation carriers can be at increased cardiovascular risk. The goal of this review is to provide information about factors associated with increased cardiovascular risk, methods to prevent cardiovascular toxicities, and recommended screening guidelines. RECENT FINDINGS: BRCA1/2 mutation carriers who are diagnosed with cancer are often exposed to chemotherapy, chest radiotherapy, and/or HER2 directed therapies, all of which can be cardiotoxic...
March 1, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29487330/internal-motion-estimation-by-internal-external-motion-modeling-for-lung-cancer-radiotherapy
#17
Haibin Chen, Zichun Zhong, Yiwei Yang, Jiawei Chen, Linghong Zhou, Xin Zhen, Xuejun Gu
The aim of this study is to develop an internal-external correlation model for internal motion estimation for lung cancer radiotherapy. Deformation vector fields that characterize the internal-external motion are obtained by respectively registering the internal organ meshes and external surface meshes from the 4DCT images via a recently developed local topology preserved non-rigid point matching algorithm. A composite matrix is constructed by combing the estimated internal phasic DVFs with external phasic and directional DVFs...
February 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29483745/-dosimetric-analysis-of-volumetric-modulated-arc-therapy-and-intensity-modulated-radiotherapy-for-patients-undergone-breast-conserving-operation
#18
H T Sun, R J Yang, P Jiang, W J Jiang, J N Li, N Meng, J J Wang
OBJECTIVE: To compare the dosimetric differences between volumetric modulated arc therapy and intensity modulated radiotherapy for breast cancer patients after breast-conserving surgery. METHODS: Ten patients who received radiotherapy after breast-conserving surgery were selected. Eclipse planning system was used to design volumetric rotating intensity-modulated (2F-RapidArc) and two field intensity-modulated radiation therapy (2F-IMRT) planning for each patient...
February 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29475525/high-let-radiation-shows-no-major-cellular-and-functional-effects-on-primary-cardiomyocytes-in-vitro
#19
Anja Heselich, Johannes L Frieß, Sylvia Ritter, Naja P Benz, Paul G Layer, Christiane Thielemann
It is well known that ionizing radiation causes adverse effects on various mammalian tissues. However, there is little information on the biological effects of heavy ion radiation on the heart. In order to fill this gap, we systematically examined DNA-damage induction and repair, as well as proliferation and apoptosis in avian cardiomyocyte cultures irradiated with heavy ions such as titanium and iron, relevant for manned space-flight, and carbon ions, as used for radiotherapy. Further, and to our knowledge for the first time, we analyzed the effect of heavy ion radiation on the electrophysiology of primary cardiomyocytes derived from chicken embryos using the non-invasive microelectrode array (MEA) technology...
February 2018: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29474098/comparing-four-radiotherapy-techniques-for-treating-the-chest-wall-plus-levels-iii-iv-draining-nodes-after-breast-reconstruction
#20
Valentina Lancellotta, Martina Iacco, Elisabetta Perrucci, Lorenzo Falcinelli, Claudio Zucchetti, Berardino de Bari, Simonetta Saldi, Cynthia Aristei
OBJECTIVE: To compare the dosimetric outcomes of four radiotherapy (RT) techniques for treating the chest wall plus draining nodes after mastectomy and breast reconstruction. METHODS: Three-dimensional conformal radiotherapy (3DCRT), linac-based intensity modulated radiotherapy, helical tomotherapy (HT) and direct tomotherapy (DT) treatments were planned for 40 breast cancer patients. Dose prescription was 50 Gy. Plans were compared in terms of doses to the planning target volume, organs at risk (OARs) and the homogeneity index (HI)...
February 23, 2018: British Journal of Radiology
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