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https://www.readbyqxmd.com/read/29683522/magnifying-lenses-to-aid-umbilical-catheter-insertion
#1
Aisling M O'Riordan, Oksana Kozdoba, John Fa Murphy, Lisa K McCarthy
Umbilical venous and arterial catheters are frequently inserted into critically ill and preterm newborns in the neonatal intensive care unit (NICU) to administer fluids, drugs and parenteral nutrition; to monitor blood pressure; and for blood sampling(1). Successful catheterisation can be difficult and failure is common because the vessels are small, they are mobile, slippery and easily traumatised. Repeated probing and failure to adequately dilate the opening can cause a false passage adjacent to the vessel that is difficult to correct(2)...
April 23, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29682549/preliminary-exploration-of-epidemiologic-and-hemodynamic-characteristics-of-restrictive-filling-diastolic-dysfunction-based-on-echocardiography-in-critically-ill-patients-a-retrospective-study
#2
Yi Li, Wanhong Yin, Yao Qin, Xueying Zeng, Tongjuan Zou, Xiaoting Wang, Yangong Chao, Lina Zhang, Yan Kang, Chinese Critical Ultrasound Study Group Ccusg
Objective: To preliminarily describe the epidemiologic and hemodynamic characteristics of critically ill patients with restrictive filling diastolic dysfunction based on echocardiography. Setting: A retrospective study. Methods: Epidemiologic characteristics of patients with restrictive filling diastolic dysfunction in ICU were described; clinical and hemodynamic data were preliminarily summarized and compared between patients with and without restrictive filling diastolic dysfunction; most of the data were based on echocardiography...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682503/imaging-behavior-and-endocrine-analysis-of-jealousy-in-a-monogamous-primate
#3
Nicole Maninger, Sally P Mendoza, Donald R Williams, William A Mason, Simon R Cherry, Douglas J Rowland, Thomas Schaefer, Karen L Bales
Understanding the neurobiology of social bonding in non-human primates is a critical step in understanding the evolution of monogamy, as well as understanding the neural substrates for emotion and behavior. Coppery titi monkeys ( Callicebus cupreus ) form strong pair bonds, characterized by selective preference for their pair mate, mate-guarding, physiological and behavioral agitation upon separation, and social buffering. Mate-guarding, or the "maintenance" phase of pair bonding, is relatively under-studied in primates...
October 2017: Frontiers in Ecology and Evolution
https://www.readbyqxmd.com/read/29680878/quantitative-computed-tomography-in-comparison-with-transpulmonary-thermodilution-for-the-estimation-of-pulmonary-fluid-status-a-clinical-study-in-critically-ill-patients
#4
Bernd Saugel, Moritz Wildgruber, Albrecht Staudt, Michael Dieckmeyer, Konstantin Holzapfel, Georgios Kaissis, Mikhail Y Kirov, Vsevolod V Kuzkov, Roland M Schmid, Wolfgang Huber
Extravascular lung water (index) (EVLW(I)) can be estimated using transpulmonary thermodilution (TPTD). Computed tomography (CT) with quantitative analysis of lung tissue density has been proposed to quantify pulmonary edema. We compared variables of pulmonary fluid status assessed using quantitative CT and TPTD in critically ill patients. In 21 intensive care unit patients, we performed TPTD measurements directly before and after chest CT. Based on the density data of segmented CT images we calculated the tissue volume (TV), tissue volume index (TVI), and the mean weighted index of voxel aqueous density (VMWaq)...
April 21, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29680334/open-heart-surgery-for-management-of-right-auricular-thrombus-related-to-central-venous-catheterization
#5
A F Ribeiro, I S Neto, I Maia, C Dias
Central venous catheters are widely used in critically ill patients; however, they are also associated with increased morbidity and mortality. The literature may underestimate the incidence of catheter-inducible right atrial thrombi that are asymptomatic but potentially life threatening. The recognized risk factors for its development include infections related to the catheter, endothelial injury secondary to mechanical and chemical damage induced by certain medications and infused fluids. The characteristics of the patient and the catheter, such as size, material, type, location and ease of insertion, as well as the duration of placement play an additional role...
April 19, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29679204/efficacy-of-curcumin-for-age-associated-cognitive-decline-a-narrative-review-of-preclinical-and-clinical-studies
#6
REVIEW
Marjana Rahman Sarker, Susan F Franks
Processes such as aberrant redox signaling and chronic low-grade systemic inflammation have been reported to modulate age-associated pathologies such as cognitive impairment. Curcumin, the primary therapeutic component of the Indian spice, Turmeric (Curcuma longa), has long been known for its strong anti-inflammatory and antioxidant activity attributable to its unique molecular structure. Recently, an interest in this polyphenol as a cognitive therapeutic for the elderly has emerged. The purpose of this paper is to critically review preclinical and clinical studies that have evaluated the efficacy of curcumin in ameliorating and preventing age-associated cognitive decline and address the translational progress of preclinical to clinical efficacy...
April 21, 2018: GeroScience
https://www.readbyqxmd.com/read/29677005/maged2-a-novel-form-of-antenatal-bartter-s-syndrome
#7
Martin Kömhoff, Kamel Laghmani
PURPOSE OF REVIEW: Antenatal Bartter's syndrome (aBS) is the most severe form of Bartter's syndrome, requiring close follow-up, in particular during the neonatal period, primarily because of prematurity. The recent identification of a novel and very severe form of aBS merits an update on this topic. RECENT FINDING: Despite the identification of several genes involved in Bartter's syndrome, about 20% of patients clinically diagnosed with aBS remained without genetic explanation for decades...
April 18, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29676680/midline-central-fluid-percussion-model-of-traumatic-brain-injury-in-pediatric-and-adolescent-rats
#8
Rachel K Rowe, Jordan L Harrison, Timothy W Ellis, P David Adelson, Jonathan Lifshitz
OBJECTIVE Experimental traumatic brain injury (TBI) models hold significant validity to the human condition, with each model replicating a subset of clinical features and symptoms. TBI is the leading cause of mortality and morbidity in children and teenagers; thus, it is critical to develop preclinical models of these ages to test emerging treatments. Midline fluid percussion injury (FPI) might best represent mild and diffuse clinical brain injury because of the acute behavioral deficits, the late onset of behavioral morbidities, and the absence of gross histopathology...
April 20, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29676403/combined-endoscopic-transorbital-and-endonasal-repair-of-high-flow-orbital-apex-middle-fossa-cerebrospinal-fluid-leak-with-a-nasoseptal-flap
#9
Brandon Lucke-Wold, Gustavo Mendez, David Cua, Paul Akins, Haley Gillham, Jeremy Ciporen
Background and importance: High flow orbital apex or middle fossa cerebrospinal fluid (CSF) leaks can be life threatening and complex to repair. These leaks associated with large dural defects are most commonly repaired with an open temporalis muscle patch or free flaps, but these flaps do not always stop the leak. Clinical Presentation: A 65-year-old patient presented two years after orbital exenteration and radiation for squamous cell carcinoma. He developed multi-organism meningitis and pneumocephalus secondary to a large high-flow orbital apex/middle fossa CSF leak...
2018: Journal of neuroinflammation and neurodegenerative diseases
https://www.readbyqxmd.com/read/29675697/computational-fluid-dynamics-assessment-associated-with-transcatheter-heart-valve-prostheses-a-position-paper-of-the-iso-working-group
#10
REVIEW
Zhenglun Alan Wei, Simon Johannes Sonntag, Milan Toma, Shelly Singh-Gryzbon, Wei Sun
The governing international standard for the development of prosthetic heart valves is International Organization for Standardization (ISO) 5840. This standard requires the assessment of the thrombus potential of transcatheter heart valve substitutes using an integrated thrombus evaluation. Besides experimental flow field assessment and ex vivo flow testing, computational fluid dynamics is a critical component of this integrated approach. This position paper is intended to provide and discuss best practices for the setup of a computational model, numerical solving, post-processing, data evaluation and reporting, as it relates to transcatheter heart valve substitutes...
April 19, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29672056/leidenfrost-self-rewetting-drops
#11
Safouene Ouenzerfi, Souad Harmand, Jesse Schiffler
As discovered by Leidenfrost, liquids placed on very hot solids levitate on a cushion of their own vapour. This is called also calefaction phenomenon, a dynamical and transient effect, as vapour is injected below the liquid and pressed by the drop weigh. To account the film vapor, we consider the surface tension magnitude as well as the Marangoni effect (in particular the thermal one) which arise with imbalance of surface tension forces. For standard liquids, these forces contribute to amplify the thickness of film layer and the levitation of the droplet...
April 19, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29665381/a-refined-developability-classification-system-rdcs
#12
J Rosenberger, J Butler, J Dressman
In 2010, the Developability Classification System (DCS) was proposed. The DCS was deigned to close the gap between the BCS, which is aimed at guiding regulatory decisions about well-characterized drugs, and the need for early evaluation of drug candidates with respect to their suitability for oral delivery. The DCS applied solubility in FaSSIF to estimate intestinal solubility, assessed the compensatory nature of permeability and solubility during oral absorption and provided a way of estimating the critical the particle size at which dissolution becomes rate-limiting to absorption...
April 14, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29665377/impact-of-super-disintegrants-and-film-thickness-on-disintegration-time-of-strip-films-loaded-with-poorly-water-soluble-drug-microparticles
#13
Lu Zhang, Marie Aloia, Barbara Pielecha-Safira, Honghao Lin, Prarthana Manoj Rajai, Kuriakose Kunnath, Rajesh N Davé
Although strip films are a promising platform for delivery of poorly water-soluble drug particles via slurry casting, the effect of critical materials attributes (CMAs), e.g., super-disintegrants on critical quality attributes (CQAs), including film disintegration time (DT), remains under-explored. A two-level factorial design is considered to examine the impact of the super-disintegrant (SDI) type (sodium starch glycolate and croscarmellose sodium), their amount, and film thickness. SDIs were used with hydroxypropyl methylcellulose (HPMC-E15LV) and glycerin solutions along with viscosity matching...
April 14, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29660973/computation-of-hemodynamics-in-eccentric-coronary-stenosis-a-morphological-parametric-study
#14
Xinzhou Xie, Yabing Li, Songyun Xie
BACKGROUND: Flow recirculation occurs in eccentric coronary stenosis, which can lead to adverse outcome. The complex local geodesic patterns of eccentric stenosis are critical factors in determining the flow characteristics in post-stenotic flow. OBJECTIVE: The main objective of this study is to relate the relationship between the detailed morphological parameters in eccentric coronary stenosis and the post-stenotic flow characteristics. METHODS: Several idealized eccentric coronary stenosis models with variable morphological parameters are created to conduct a series of computational fluid dynamics analysis...
April 7, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29660682/insights-into-the-binding-behavior-of-bovine-serum-albumin-to-black-carbon-nanoparticles-and-induced-cytotoxicity
#15
Hai Wu, Miaomiao Chen, Mengting Shang, Xiang Li, Kui Mu, Suhua Fan, Shuanglin Jiang, Wenyong Li
Black carbon (BC) is a main component of particulate matter (PM2.5 ). Due to their small size (<100nm), inhaled ultrafine BC nanoparticles may penetrate the lung alveoli, where they interact with surfactant proteins and lipids, causing more serious damage to human health. Here, BC was analyzed to investigate the binding mechanism of its interaction with protein and induction of cytotoxicity changes. The binding process and protein conformation between BC and a serum protein (bovine serum albumin, BSA) were monitored by using a fluorescence quenching technique and UV-vis absorption, Fourier transform infrared (FTIR) and circular dichroism (CD) spectroscopies...
April 6, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29659729/t-helper-17-1-cells-associate-with-multiple-sclerosis-disease-activity-perspectives-for-early-intervention
#16
Jamie van Langelaar, Roos M van der Vuurst de Vries, Malou Janssen, Annet F Wierenga-Wolf, Isis M Spilt, Theodora A Siepman, Wendy Dankers, Georges M G M Verjans, Helga E de Vries, Erik Lubberts, Rogier Q Hintzen, Marvin M van Luijn
Interleukin-17-expressing CD4+ T helper 17 (Th17) cells are considered as critical regulators of multiple sclerosis disease activity. However, depending on the species and pro-inflammatory milieu, Th17 cells are functionally heterogeneous, consisting of subpopulations that differentially produce interleukin-17, interferon-gamma and granulocyte macrophage colony-stimulating factor. In the current study, we studied distinct effector phenotypes of human Th17 cells and their correlation with disease activity in multiple sclerosis patients...
April 5, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29659087/robust-spinal-cord-resting-state-fmri-using-independent-component-analysis-based-nuisance-regression-noise-reduction
#17
Yong Hu, Richu Jin, Guangsheng Li, Keith Dk Luk, Ed X Wu
BACKGROUND: Physiological noise reduction plays a critical role in spinal cord (SC) resting-state fMRI (rsfMRI). PURPOSE: To reduce physiological noise and increase the robustness of SC rsfMRI by using an independent component analysis (ICA)-based nuisance regression (ICANR) method. STUDY TYPE: Retrospective. SUBJECTS: Ten healthy subjects (female/male = 4/6, age = 27 ± 3 years, range 24-34 years). FIELD STRENGTH/SEQUENCE: 3T/gradient-echo echo planar imaging (EPI)...
April 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29657606/early-biliary-drainage-is-associated-with-favourable-outcomes-in-critically-ill-patients-with-acute-cholangitis
#18
Mohammed Aboelsoud, Osama Siddique, Alexander Morales, Young Seol, Mazen Al-Qadi
Introduction: Acute cholangitis (AC) is a clinical condition that requires prompt medical management with IV fluids, antibiotics, and biliary drainage (BD). The optimal timing for BD remains unclear. Aim: To investigate the effect of biliary drainage timing on clinical outcomes in AC. Material and methods: We conducted a retrospective study of patients with AC admitted to the ICU using the Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC-III) database...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29657376/smoke-inhalation-injury-etiopathogenesis-diagnosis-and-management
#19
REVIEW
Kapil Gupta, Mayank Mehrotra, Parul Kumar, Anoop Raj Gogia, Arun Prasad, Joseph Arnold Fisher
Smoke inhalation injury is a major determinant of morbidity and mortality in fire victims. It is a complex multifaceted injury affecting initially the airway; however, in short time, it can become a complex life-threatening systemic disease affecting every organ in the body. In this review, we provide a summary of the underlying pathophysiology of organ dysfunction and provide an up-to-date survey of the various critical care modalities that have been found beneficial in caring for these patients. Major pathophysiological change is development of edema in the respiratory tract...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29657372/targeted-interventions-in-critically-ill-children-with-severe-dengue
#20
Suchitra Ranjit, Gokul Ramanathan, Balasubramaniam Ramakrishnan, Niranjan Kissoon
Background: The World Health Organization guidelines provide suggestions on early recognition and treatment of severe dengue (SD); however, mortality in this group can be high and is related both to disease severity and the treatment complications. Subjects and Methods: In this prospective observational study, we report our results where standard therapy (ST) was enhanced by Intensive Care Unit (ICU) supportive measures that have proven beneficial in other conditions that share similar pathophysiology of capillary leak and fluid overload...
March 2018: Indian Journal of Critical Care Medicine
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