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"Macrophage Migration Inhibitory Factor"

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https://www.readbyqxmd.com/read/29621201/remote-ischemic-preconditioning-does-not-affect-the-release-of-humoral-factors-in-propofol-anesthetized-cardiac-surgery-patients-a-secondary-analysis-of-the-ripheart-study
#1
Julia Ney, Katleen Hoffmann, Patrick Meybohm, Andreas Goetzenich, Sandra Kraemer, Carina Benstöm, Nina C Weber, Johannes Bickenbach, Rolf Rossaint, Gernot Marx, Kai Zacharowski, Jürgen Bernhagen, Christian Stoppe
In contrast to several smaller studies, which demonstrate that remote ischemic preconditioning (RIPC) reduces myocardial injury in patients that undergo cardiovascular surgery, the RIPHeart study failed to demonstrate beneficial effects of troponin release and clinical outcome in propofol-anesthetized cardiac surgery patients. Therefore, we addressed the potential biochemical mechanisms triggered by RIPC. This is a predefined prospective sub-analysis of the randomized and controlled RIPHeart study in cardiac surgery patients ( n = 40) that was recently published...
April 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29602581/macrophage-migration-inhibitory-factor-mif-is-associated-with-degree-of-collateralization-in-patients-with-totally-occluded-coronary-arteries
#2
Luigi Di Serafino, Jozef Bartunek, Guy Heyndrickx, Karen Dierickx, Gabriella Scognamiglio, Tullio Tesorio, Bernard De Bruyne, Bruno Trimarco, William Wijns, Emanuele Barbato
BACKGROUND: Collaterals in patients with coronary artery disease (CAD) limit myocardial infarction and improve survival. Macrophage migration inhibitory factor (MIF) might play a role in collateral development. We aimed this study to evaluate the association of Macrophage migration Inhibitory Factor (MIF) with the extent of collateralization in patients with coronary occlusion. METHODS AND RESULTS: We consecutively enrolled: a) 40 patients undergoing PCI of a chronic coronary total occlusion (CTO); b) 26 patients with ST-elevation myocardial infarction (STEMI) undergoing primary PCI (pPCI) of the infarct-related artery (IRA); c) 12 control patients undergoing angiography without significant coronary artery disease (CTRL)...
March 21, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29601965/high-yield-production-of-human-invariant-chain-cd74-constructs-fused-to-solubility-enhancing-peptides-and-characterization-of-their-mif-binding-capacities
#3
Tjie Kok, Anna A Wasiel, Frank J Dekker, Gerrit J Poelarends, Robbert H Cool
The HLA class II histocompatibility antigen gamma chain, also known as HLA-DR antigen-associated invariant chain or CD74, has been shown to be involved in many biological processes amongst which antigen loading and transport of MHC class II molecules from the endoplasmic reticulum to the Golgi complex. It is also part of a receptor complex for Macrophage Migration Inhibitory Factor (MIF), and participates in inflammatory signaling. The inhibition of MIF-CD74 complex formation is regarded as a potentially attractive therapeutic target in inflammation, cancer and immune diseases...
March 27, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29592775/macrophage-migration-inhibitory-factor-receptor-cd74-is-overexpressed-in-human-and-baboon-papio-anubis-endometriotic-lesions-and-modulates-endometriotic-epithelial-cell-survival-and-interleukin-8-expression
#4
Warren B Nothnick, Tommaso Falcone, Mark R Olson, Asgerally T Fazleabas, Ossama W Tawfik, Amanda Graham
CD74 is the primary receptor for macrophage migration inhibitory factor (MIF). Although expression of MIF has been described in endometriotic lesions, the cellular localization and function of the MIF receptor, CD74, are poorly understood. To further explore the role of CD74 in the pathophysiology of endometriosis, we utilized specimens from women with diagnostically confirmed endometriosis, women with no signs or symptoms of endometriosis (controls), and 8 baboons with experimentally induced endometriosis...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29590229/association-of-oxytocin-with-glucose-intolerance-and-inflammation-biomarkers-in-metabolic-syndrome-patients-with-and-without-prediabetes
#5
Amal Akour, Violet Kasabri, Nailya Bulatova, Suha Al Muhaissen, Randa Naffa, Hiba Fahmawi, Munther Momani, Ayman Zayed, Yasser Bustanji
OBJECTIVES: The aim of this study was to explore the differences in OXT levels in metabolic syndrome (MetS) subjects, newly diagnosed type 2 diabetes mellitus (T2D), and prediabetes subjects vs. MetS subjects without glucose intolerance (non-diabetic MetS). It was also intended to determine the relationship between plasma OXT levels and inflammatory markers in those subjects. METHODS: Along with 45 lean and normoglycemic controls, a total of 190 MetS subjects (61 men, 129 women) were enrolled...
2018: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/29580781/elevated-urine-levels-of-macrophage-migration-inhibitory-factor-in-inflammatory-bladder-conditions-a-potential-biomarker-for-a-subgroup-of-interstitial-cystitis-bladder-pain-syndrome-patients
#6
Pedro L Vera, David M Preston, Robert M Moldwin, Deborah R Erickson, Behzad Mowlazadeh, Fei Ma, Dimitrios E Kouzoukas, Katherine L Meyer-Siegler, Magnus Fall
(1) Objectives: To investigate whether urinary levels of macrophage migration inhibitory factor (MIF) are elevated in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) patients with Hunner lesions and also whether urine MIF is elevated in other forms of inflammatory cystitis. (2) Methods: Urine samples were assayed for MIF by ELISA. Urine samples from three female groups were examined: IC/BPS patients without (N=55) and with Hunner lesions (N=43); Non-IC/BPS patients (N=100; control group; no history of IC/BPS; cancer or recent bacterial cystitis)...
March 23, 2018: Urology
https://www.readbyqxmd.com/read/29578285/comparative-proteomics-analysis-reveals-trans-fatty-acid-isomers-activates-different-pathways-in-human-umbilical-vein-endothelial-cell
#7
Bin Qiu, Qing Wang, Fang-Ling Du, Li-Na Liu, Ai-Zhen Zong, Min Jia, Wei Liu, Tong-Cheng Xu
Trans fatty acid (TFA), a group of unsaturated fats with at least one double bond in the trans configuration, plays a role in lipid metabolism, the structure of the cell membrane phospholipids, and apoptosis. Previous studies demonstrated that TFA was associated with coronary heart disease, obesity, and insulin resistance. Herein, a quantitative proteomics approach estimated the relative abundance of proteins in human umbilical vein endothelial cells treated with TFA (two different TFA structural isomers: 9t-18:1 and 9t,12t-18:2)...
February 2018: Lipids
https://www.readbyqxmd.com/read/29575754/optimization-of-pyrazoles-as-phenol-surrogates-to-yield-potent-inhibitors-of-macrophage-migration-inhibitory-factor
#8
Vinay Trivedi-Parmar, Michael J Robertson, Jose A Cisneros, Stefan G Krimmer, William L Jorgensen
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is implicated in the regulation of inflammation, cell proliferation, and neurological disorders. MIF is also an enzyme that functions as a keto-enol tautomerase. Most potent MIF tautomerase inhibitors incorporate a phenol, which hydrogen bonds to Asn97 in the active site. Starting from a 113-μM docking hit, we report results of structure-based and computer-aided design that have provided substituted pyrazoles as phenol alternatives with potencies of 60-70 nM...
March 25, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29566294/inflammatory-cytokine-mediated-induction-of-serine-racemase-in-atopic-dermatitis
#9
Yoko Yoshihisa, Mati Ur Rehman, Maho Nakagawa, Shoko Matsukuma, Teruhiko Makino, Hisashi Mori, Tadamichi Shimizu
Serine racemase (SR) is an enzyme that catalyses the synthesis of d-serine, an endogenous coagonist for N-methyl-D-aspartate (NMDA)-type glutamate receptor in the central nervous system. Our previous study demonstrated that SR was expressed in the epidermis of wild-type (WT) mice but not in SR knockout (KO) mice. In addition, SR immune-reactivity was only found in the granular and cornified layers of the epidermis in WT mice. These findings suggested that SR is involved in the differentiation of epidermal keratinocytes and the formation of the skin barrier...
March 22, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29564801/bioinformatics-based-therapeutic-effects-of-sinomenium-acutum
#10
Yu-Yan Li, Guang Zheng, Liang Liu
OBJECTIVE: To decipher the possible mechanisms of Sinomenium Acutum (SA) in treating diseases by a bioinformatics method. METHODS: SA ingredients were searched according to Chinese Pharmacopoeia, Chinese Medicine Dictionary and Traditional Chinese Medicines Database (TCMD). Active compounds and target proteins of SA were acquired through the Pubchem platform. Pathway, network and function analyses of SA were performed with ingenuity pathway analysis (IPA), a bioinformatics analysis platform...
March 21, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29545822/macrophage-migration-inhibitory-factor-173-g-c-polymorphism-a-global-meta-analysis-across-the-disease-spectrum
#11
Oscar Illescas, Juan C Gomez-Verjan, Lizbeth García-Velázquez, Tzipe Govezensky, Miriam Rodriguez-Sosa
Human macrophage migration inhibitory factor (MIF) is a cytokine that plays a role in several metabolic and inflammatory processes. Single nucleotide polymorphism (SNP) -173 G/C (rs755622) on MIF gene has been associated with numerous diseases, such as arthritis and cancer. However, most of the reports concerning the association of MIF with these and other pathologies are inconsistent and remain quite controversial. Therefore, we performed a meta-analysis from 96 case-control studies on -173 G/C MIF SNP and stratified the data according to the subjects geographic localization or the disease pathophysiology, in order to determine a more meaningful significance to this SNP...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29543531/mif-deficiency-favors-an-atheroprotective-autoantibody-phenotype-in-atherosclerosis
#12
Corinna Schmitz, Heidi Noels, Omar El Bounkari, Eva Straussfeld, Remco T A Megens, Marieke Sternkopf, Setareh Alampour-Rajabi, Christine Krammer, Pathricia V Tilstam, Norbert Gerdes, Christina Bürger, Aphrodite Kapurniotu, Richard Bucala, Joachim Jankowski, Christian Weber, Jürgen Bernhagen
The inflammatory cytokine macrophage migration-inhibitory factor (MIF) promotes atherosclerosis via lesional monocyte and T-cell recruitment. B cells have emerged as important components in atherogenesis, but the interaction between MIF and B cells in atherogenesis is unknown. Here, we investigated the atherosclerotic phenotype of Mif-gene deletion in Apoe-/- mice. Apoe-/- Mif-/- mice on a Western-diet exhibited strongly reduced atherosclerotic lesions in brachiocephalic artery (BC) and abdominal aorta compared with controls...
March 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29540068/emerging-therapeutic-biomarkers-of-autoimmune-hepatitis-and-their-impact-on-current-and-future-management
#13
Albert J Czaja
Autoimmune hepatitis lacks a quantifiable biomarker that is close to its pathogenic mechanisms and that accurately reflects inflammatory activity, correlates with treatment response, and ensures inactive disease before treatment withdrawal. Areas covered: Micro-ribonucleic acids, programmed death-1 protein and its ligands, macrophage migration inhibitory factor, soluble CD163, B cell activating factor, and metabolite patterns in blood were considered the leading candidates as therapeutic biomarkers after search of PubMed from August 1981 to August 2017 using the search words 'biomarkers of autoimmune hepatitis'...
March 20, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29526099/design-synthesis-and-biological-activity-of-new-n-phenylmethyl-benzoxazol-2-thiones-as-macrophage-migration-inhibitory-factor-mif-antagonists-efficacies-in-experimental-pulmonary-hypertension
#14
Morane Le Hiress, Bernardin Akagah, Guillaume Bernadat, Ly Tu, Raphaël Thuillet, Alice Huertas, Carole Phan, Elie Fadel, Gérald Simonneau, Marc Humbert, Gaël Jalce, Christophe Guignabert
Macrophage migration inhibitory factor (MIF) is a key pleiotropic mediator and a promising therapeutic target in cancer as well as in several inflammatory and cardiovascular diseases including pulmonary arterial hypertension (PAH). Here, a novel series of N-(phenylmethyl)-benzoxazol-2-thiones 5-32 designed to target the MIF tautomerase active site was synthesized and evaluated for its effects on cell survival. Investigation of structure-activity relationship (SAR) particularly at the 5-position of the benzoxazole core led to the identification of 31 that potently inhibits cell survival in DU-145 prostate cancer cells and pulmonary endothelial cells derived from patients with idiopathic PAH (iPAH-ECs), two cell lines for which survival is MIF-dependent...
March 10, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29512741/macrophage-migration-inhibitory-factor-antagonist-s-r-3%C3%A2-4%C3%A2-hydroxyphenyl-%C3%A2-4-5%C3%A2-dihydro%C3%A2-5%C3%A2-isoxazole-acetic-acid-methyl-ester-attenuates-inflammation-and-lung-injury-in-rats-with-acute-pancreatitis-in-pregnancy
#15
Yu Zhou, Liang Zhao, Fangchao Mei, Yupu Hong, He Xia, Teng Zuo, Youming Ding, Weixing Wang
Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine involved in many acute and chronic inflammatory diseases. However, its role in acute lung injury associated with acute pancreatitis in pregnancy (APIP) has not yet been elucidated. The present study was undertaken to clarify the effect and potential mechanism of MIF antagonist (S,R)3‑(4‑hydroxyphenyl)‑4,5‑dihydro‑5‑isoxazole acetic acid methyl ester (ISO‑1) in the development of acute lung injury in rats with APIP. Eighteen late‑gestation SD rats were randomly assigned to three groups: Sham operation (SO) group, APIP group, and ISO‑1 group...
March 1, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29510402/oxymatrine-inhibits-homocysteine-mediated-autophagy-via-mif-mtor-signaling-in-human-umbilical-vein-endothelial-cells
#16
Yanyan Zhang, Yuan Zhang, Jiayu Tang, Shuang Zhao, Chen Li, Yong-Pan Huang, Minhan Yi
BACKGROUND/AIMS: Genetic or nutritional deficiencies in homocysteine (Hcy)metabolism lead to the accumulation of Hcy and its metabolites in the blood. This can lead to hyperhomocysteinemia (HHcy), which is an independent risk factor for cardiovascular disease. Studies have shown that HHcy leads to endothelial dysfunction, a hallmark of atherosclerosis, which may explain this link. The precise mechanism remains unclear, but a strong possibility is excessive HHCy-induced autophagy. Autophagy has been better studied in ischemia/reperfusion (I/R) injuries, and previous work showed that Oxymatrine (OMT), a quinolizidine alkaloid, protects cells against myocardial I/R injury by inhibiting autophagy...
February 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29504609/macrophage-migration-inhibitory-factor-mediates-peripheral-nerve-injury-induced-hypersensitivity-by-curbing-dopaminergic-descending-inhibition
#17
Xian Wang, Shaolei Ma, Haibo Wu, Xiaofeng Shen, Shiqin Xu, Xirong Guo, Maria L Bolick, Shizheng Wu, Fuzhou Wang
Our previous works disclosed the contributing role of macrophage migration inhibitory factor (MIF) and dopaminergic inhibition by lysine dimethyltransferase G9a/Glp complex in peripheral nerve injury-induced hypersensitivity. We herein propose that the proinflammatory cytokine MIF participates in the regulation of neuropathic hypersensitivity by interacting with and suppressing the descending dopaminergic system. The lumbar spinal cord (L-SC) and ventral tegmental area (VTA) are two major locations with significant upregulation of MIF after chronic constriction injury (CCI) of the sciatic nerve, and they display time-dependent changes, along with a behavioral trajectory...
February 16, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29497418/african-trypanosomiasis-associated-anemia-the-contribution-of-the-interplay-between-parasites-and-the-mononuclear-phagocyte-system
#18
REVIEW
Benoit Stijlemans, Patrick De Baetselier, Stefan Magez, Jo A Van Ginderachter, Carl De Trez
African trypanosomosis (AT) is a chronically debilitating parasitic disease of medical and economic importance for the development of sub-Saharan Africa. The trypanosomes that cause this disease are extracellular protozoan parasites that have developed efficient immune escape mechanisms to manipulate the entire host immune response to allow parasite survival and transmission. During the early stage of infection, a profound pro-inflammatory type 1 activation of the mononuclear phagocyte system (MPS), involving classically activated macrophages (i...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29487601/serum-levels-of-migration-inhibitory-factor-mif-and-in-situ-expression-of-mif-and-its-receptor-cd74-in-lepromatous-leprosy-patients-a-preliminary-report
#19
Marco Alonso Martinez-Guzman, Anabell Alvarado-Navarro, Vidal Delgado-Rizo, Alejandra Garcia-Orozco, Jorge Arturo Mayorga-Rodríguez, Ana Laura Pereira-Suarez, Mary Fafutis-Morris
Leprosy is a chronic disease caused by Mycobacterium leprae that affects the skin and peripheral nerves. It may present as one of two distinct poles: the self-limiting tuberculoid leprosy and the highly infectious lepromatous leprosy (LL) characterized by M. leprae -specific absence of cellular immune response. The pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) enhance the bactericide activities of macrophages after interaction with its receptor, CD74. Importantly, MIF also possesses chemoattractant properties, and it is a key factor in situ for the activation of macrophages and in blood to promote leukocytes migration...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29487418/hif1%C3%AE-drives-chemokine-factor-pro-tumoral-signaling-pathways-in-acute-myeloid-leukemia
#20
Amina M Abdul-Aziz, Manar S Shafat, Yu Sun, Christopher R Marlein, Rachel E Piddock, Stephen D Robinson, Dylan R Edwards, Zhigang Zhou, Angela Collins, Kristian M Bowles, Stuart A Rushworth
Approximately 80% of patients diagnosed with acute myeloid leukemia (AML) die as a consequence of failure to eradicate the tumor from the bone marrow microenvironment. We have recently shown that stroma-derived interleukin-8 (IL-8) promotes AML growth and survival in the bone marrow in response to AML-derived macrophage migration inhibitory factor (MIF). In the present study we show that high constitutive expression of MIF in AML blasts in the bone marrow is hypoxia-driven and, through knockdown of MIF, HIF1α and HIF2α, establish that hypoxia supports AML tumor proliferation through HIF1α signaling...
February 28, 2018: Oncogene
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