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"Macrophage Migration Inhibitory Factor"

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https://www.readbyqxmd.com/read/29027966/myocardial-expression-of-macrophage-migration-inhibitory-factor-in-patients-with-heart-failure
#1
Julia Pohl, Ulrike B Hendgen-Cotta, Pia Stock, Peter Luedike, Hideo Andreas Baba, Markus Kamler, Tienush Rassaf
Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory protein and contributes to several different inflammatory and ischemic/hypoxic diseases. MIF was shown to be cardioprotective in experimental myocardial ischemia/reperfusion injury and its expression is regulated by the transcription factor hypoxia-inducible factor (HIF)-1α. We here report on MIF expression in the failing human heart and assess myocardial MIF in different types of cardiomyopathy. Myocardial tissue samples from n = 30 patients were analyzed by quantitative Real-Time PCR...
October 13, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28993199/unraveling-the-role-of-hypoxia-inducible-factor-hif-1%C3%AE-and-hif-2%C3%AE-in-the-adaption-process-of-human-microvascular-endothelial-cells-hmec-1-to-hypoxia-redundant-hif-dependent-regulation-of-macrophage-migration-inhibitory-factor
#2
Martin Hahne, Peggy Schumann, Mathias Mursell, Cindy Strehl, Paula Hoff, Frank Buttgereit, Timo Gaber
Hypoxia driven angiogenesis is a prominent feature of tissue regeneration, inflammation and tumor growth and is regulated by hypoxia-inducible factor (HIF)-1 and -2. The distinct functions of HIFs in the hypoxia-induced angiogenesis and metabolic switch of endothelial cells are still unknown and therefore aim of this study. We investigated the role of HIF-1 and -2 in the adaptation of immortalized human microvascular endothelial cells (HMEC-1) to hypoxic conditions (1% O2) in terms of angiogenesis, cytokine secretion, gene expression and ATP/ADP-ratio using shRNA-mediated reduction of the oxygen sensitive α-subunits of either HIF-1 or HIF-2 or the combination of both...
October 6, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28990052/macrophage-migration-inhibitory-factor-knockdown-inhibit-viability-and-induce-apoptosis-of-pvm-ms
#3
Wenjing Zhang, Jian Zheng, Juan Meng, Lingling Neng, Xiaohua Chen, Zhaobing Qin
Previous studies have suggested that macrophage migration inhibitory factor (MIF) serves an important role in hearing function; however, the underlying mechanism remains unclear. In the present study, perivascular‑resident macrophage‑like melanocytes (PVM/Ms) from the stria vascularis of the lateral cochlear wall in young and aged mice were isolated. The mRNA and protein expression levels of MIF were determined using reverse transcription‑quantitative polymerase chain reaction analysis, and western blotting, respectively...
October 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28963807/role-of-macrophage-migration-inhibitory-factor-in-head-and-neck-cancer-and-novel-therapeutic-targets-a-systematic-review
#4
Jérôme R Lechien, Amir Nassri, Nadege Kindt, David N Brown, Fabrice Journe, Sven Saussez
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in systemic, autoimmune, and inflammatory diseases, such as obesity, rheumatoid arthritis, and systemic lupus erythematosus. For the 2 past decades, MIF has been reported to participate in carcinogenesis, disease prognosis, tumor cell proliferation, invasion, and tumor-induced angiogenesis in many cancers. The purpose of this article is to review published experimental and clinical data for MIF and its involvement in upper aerodigestive tract cancers...
September 30, 2017: Head & Neck
https://www.readbyqxmd.com/read/28941594/fenofibrate-attenuates-fatty-acid-induced-islet-%C3%AE-cell-dysfunction-and-apoptosis-via-inhibiting-the-nf-%C3%AE%C2%BAb-mif-dependent-inflammatory-pathway
#5
Shuang Zheng, Xingxing Ren, Tingting Han, Yawen Chen, Huiying Qiu, Wei Liu, Yaomin Hu
BACKGROUND: Fatty acid-induced lipotoxicity and macrophage migration inhibitory factor (MIF) affect pancreatic β-cell function, and may promote the development of diabetes mellitus. However, the association of lipotoxicity with MIF and the effect of Fenofibrate on β-cell function remain unknown. METHODS: LPL+/- mice and MIN6 cells stimulated with palmitic acid (PA) were utilized as models of lipid metabolism disorders. Factors associated with insulin secretion and apoptosis were assessed in the presence or absence of Fenofibrate...
September 20, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28928022/the-role-of-jab1-a-putative-downstream-effector-of-the-neurotrophic-cytokine-macrophage-migration-inhibitory-factor-mif-in-zebrafish-inner-ear-hair-cell-development
#6
Loren J Weber, Hannah K Marcy, Yu-Chi Shen, Sarah E Tomkovich, Kristina M Brooks, Kelly E Hilk, Kate F Barald
Macrophage migration inhibitory factor (MIF) is a neurotrophic cytokine essential for inner ear hair cell (HC) development and statoacoustic ganglion (SAG) neurite outgrowth, and SAG survival in mouse, chick and zebrafish. Another neurotrophic cytokine, Monocyte chemoattractant protein 1 (MCP1) is known to synergize with MIF; but MCP1 alone is insufficient to support mouse/chick SAG neurite outgrowth or neuronal survival. Because of the relatively short time over which the zebrafish inner ear develops (~30hpf), the living zebrafish embryo is an ideal system to examine mif and mcp1 cytokine pathways and interactions...
September 18, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28923927/mif-and-d-dt-are-potential-disease-severity-modifiers-in-male-ms-subjects
#7
Gil Benedek, Roberto Meza-Romero, Kelley Jordan, Ying Zhang, Ha Nguyen, Gail Kent, Jia Li, Edwin Siu, Jenny Frazer, Marta Piecychna, Xin Du, Antoine Sreih, Lin Leng, Jack Wiedrick, Stacy J Caillier, Halina Offner, Jorge R Oksenberg, Vijayshree Yadav, Dennis Bourdette, Richard Bucala, Arthur A Vandenbark
Little is known about mechanisms that drive the development of progressive multiple sclerosis (MS), although inflammatory factors, such as macrophage migration inhibitory factor (MIF), its homolog D-dopachrome tautomerase (D-DT), and their common receptor CD74 may contribute to disease worsening. Our findings demonstrate elevated MIF and D-DT levels in males with progressive disease compared with relapsing-remitting males (RRMS) and female MS subjects, with increased levels of CD74 in females vs. males with high MS disease severity...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28919555/disturbances-of-systemic-and-hippocampal-insulin-sensitivity-in-macrophage-migration-inhibitory-factor-mif-knockout-male-mice-lead-to-behavioral-changes-associated-with-decreased-psa-ncam-levels
#8
Ana Djordjevic, Biljana Bursać, Nataša Veličković, Ljupka Gligorovska, Djurdjica Ignjatović, Mirko Tomić, Gordana Matić
Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine well known for its role in inflammation enhancement. However, a growing body of evidence is emerging on its role in energy metabolism in insulin sensitive tissues such as hippocampus, a brain region implicated in cognition, learning and memory. We hypothesized that genetic deletion of MIF may result in the specific behavioral changes, which may be linked tо impairments in brain or systemic insulin sensitivity by possible changes of the hippocampal synaptic plasticity...
September 19, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28919396/protective-effect-of-chlorogenic-acid-on-the-inflammatory-damage-of-pancreas-and-lung-in-mice-with-l-arginine-induced-pancreatitis
#9
Tatsuya Ohkawara, Hiroshi Takeda, Jun Nishihira
AIMS: Pancreatitis is characterized by inflammatory disease with severe tissue injury in pancreas, and the incidence of pancreatitis has been recently increasing. Although several treatments of acute pancreatitis have been developed, some patients have been resistant to current therapy. Chlorogenic acid (CGA) is one of the polyphenols, and is known to have an anti-inflammatory effect. In this study, we investigated the effects of CGA on experimental pancreatitis in mice. MATERIALS AND METHODS: Pancreatitis was induced by twice injection of l-arginine (5g/kg body weight)...
December 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28912189/associations-between-circulating-macrophage-migration-inhibitory-factor-mif-levels-and-rheumatoid-arthritis-and-between-mif-gene-polymorphisms-and-disease-susceptibility-a-meta-analysis
#10
Sang-Cheol Bae, Young Ho Lee
AIM: To systematically review evidence regarding the relationship between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis (RA), and the association between MIF gene polymorphisms and RA susceptibility. DESIGN: We performed a meta-analysis on data of serum/plasma MIF levels in patients with RA and in controls, and on associations between the MIF-173 C/G and -794CATT5-8 polymorphisms and RA susceptibility. PATIENTS: Twelve studies, comprising a total of 362 RA cases and 531 controls evaluated for MIF levels, and 2367 RA cases and 2395 controls evaluated for MIF polymorphisms, were included...
September 14, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28906008/role-of-macrophage-migration-inhibitory-factor-mif-in-the-effects-of-oxidative-stress-on-human-retinal-pigment-epithelial-cells
#11
Ji-Ae Ko, Yasuyuki Sotani, Diah Gemala Ibrahim, Yoshiaki Kiuchi
Proliferative vitreoretinopathy (PVR) is the major cause of treatment failure in individuals who undergo surgery for retinal detachment. The epithelial-mesenchymal transition (EMT) in retinal pigment epithelium (RPE) cells contributes to the pathogenesis of PVR. Oxidative stress is thought to play a role in the progression of retinal diseases including PVR. We have now examined the effects of oxidative stress on the EMT and related processes in the human RPE cell line. We found that H2 O2 induced the contraction of RPE cells in a three-dimensional collagen gel...
September 14, 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/28861347/association-of-the-macrophage-migration-inhibitory-factor-promoter-polymorphisms-with-benign-lymphoepithelial-lesion-of-lacrimal-gland
#12
Qin-Jian Li, Peng-Xiang Zhao, Xu-Juan Zhang, Yang Yi, Dan-Ying Cheng, Jian-Min Ma, Xue-Mei Ma
AIM: To identify the association of the macrophage migration inhibitory factor (MIF) gene polymorphism with the susceptibility of benign lymphoepithelial lesions (BLEL) of the lacrimal gland. METHODS: A total of 40 BLEL of lacrimal gland cases were matched with 40 healthy subjects (HS). Extraction the plasma and whole blood DNA of patients of lacrimal gland BLEL and HS. Elisa and polymerase chain reaction was used to determine in plasma contents of MIF and MIF gene SNP-173G>C and STR -794 CATT(5-8) polymorphism, respectively...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28846570/macrophage-migration-inhibitory-factor-induced-autophagy-contributes-to-thrombin-triggered-endothelial-hyperpermeability-in-sepsis
#13
Chiao-Hsuan Chao, Hong-Ru Chen, Yung-Chun Chuang, Trai-Ming Yeh
Vascular leakage contributes to the high morbidity and mortality associated with sepsis. Exposure of the endothelium to inflammatory mediators, such as thrombin and cytokines, during sepsis leads to hyperpermeability. We recently observed that autophagy, a cellular process for protein turnover, is involved in macrophage migration inhibitory factor (MIF)-induced endothelial hyperpermeability. Even though it is known that thrombin induces endothelial cells to secrete MIF and to increase vascular permeability, the possible role of autophagy in this process is unknown...
August 25, 2017: Shock
https://www.readbyqxmd.com/read/28815947/olive-oil-phenolics-prevent-oxysterol-induced-pro-inflammatory-cytokine-secretion-and-ros-production-in-human-pbmcs-through-modulation-of-p38-and-jnk-pathways
#14
Gessica Serra, Monica Deiana, Jeremy P E Spencer, Giulia Corona
SCOPE: The aim of the present study was to investigate the ability of extra virgin olive oil (EVOO) polyphenols to counteract the pro-inflammatory effects induced by dietary and endogenous oxysterols in ex-vivo immune cells. METHODS AND RESULTS: Peripheral blood mononuclear cells (PBMCs), separated from the whole blood of healthy donors, were utilised and were stimulated with an oxysterols mixture, in the presence of physiologically relevant concentrations of the EVOO polyphenols, hydroxytyrosol (HT), tyrosol (TYR) and homovanillic alcohol (HVA)...
August 16, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28813470/comparison-of-macrophage-migration-inhibitory-factor-and-neutrophil-gelatinase-associated-lipocalin-2-to-predict-acute-kidney-injury-after-liver-transplantation-an-observational-pilot-study
#15
Joanna Baron-Stefaniak, Judith Schiefer, Edmund J Miller, Gabriela A Berlakovich, David M Baron, Peter Faybik
INTRODUCTION: Several biomarkers have been suggested as early predictors of acute kidney injury (AKI) after orthotopic liver transplantation (OLT). Neutrophil gelatinase-associated lipocalin-2 (NGAL) appears to be a promising predictor of AKI after OLT, but the clinical benefit remains to be proven. Recently, systemic macrophage migration inhibitory factor (MIF) has been proposed as early indicator for requirement of renal replacement therapy after OLT. The aim of this prospective, observational pilot study was to compare the predictive values of serum and urinary MIF for severe AKI after OLT to those of serum and urinary NGAL...
2017: PloS One
https://www.readbyqxmd.com/read/28801314/macrophage-migration-inhibitory-factor-limits-renal-inflammation-and-fibrosis-by-counteracting-tubular-cell-cycle-arrest
#16
Sonja Djudjaj, Ina V Martin, Eva M Buhl, Nina J Nothofer, Lin Leng, Marta Piecychna, Jürgen Floege, Jürgen Bernhagen, Richard Bucala, Peter Boor
Renal fibrosis is a common underlying process of progressive kidney diseases. We investigated the role of macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, in this process. In mice subjected to unilateral ureteral obstruction, genetic deletion or pharmacologic inhibition of MIF aggravated fibrosis and inflammation, whereas treatment with recombinant MIF was beneficial, even in established fibrosis. In two other models of progressive kidney disease, global Mif deletion or MIF inhibition also worsened fibrosis and inflammation and associated with worse kidney function...
August 11, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28780379/proinflammatory-cytokine-mif-plays-a-role-in-the-pathogenesis-of-type-2-diabetes-mellitus-but-does-not-affect-hepatic-mitochondrial-function
#17
Miriam Rodriguez-Sosa, Tecilli Cabellos-Avelar, Yuriko Sanchez-Zamora, Imelda Juárez-Avelar, Esperanza García-Reyes, Alejandra Lira-León, José Del Carmen Benítez-Flores, Thalia Pacheco-Fernández, Marcia Hiriart, Emma Berta Gutiérrez-Cirlos
BACKGROUND: Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays an important role in the pathogenesis of type 2 diabetes mellitus (T2DM). Although the effect of high glucose on liver function has been described, the role of MIF in hepatic mitochondrial function during T2DM has not been studied. OBJECTIVE: We examine the influence of MIF to hepatic mitochondrial function in T2DM mouse model. METHODS: WT and Mif(-/-) BALB/c mice were treated with a single dose of streptozotocin (STZ)...
August 2, 2017: Cytokine
https://www.readbyqxmd.com/read/28776753/assessment-of-the-involvement-of-the-macrophage-migration-inhibitory-factor-glucocorticoid-regulatory-dyad-in-the-expression-of-matrix-metalloproteinase-2-during-periodontitis
#18
Josefine Hirschfeld, Mohammed Howait, Alexandru Movila, Marijo Parčina, Isabelle Bekeredjian-Ding, James Deschner, Søren Jepsen, Toshihisa Kawai
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine and counter-regulator of endogenous glucocorticoids (GCs). It is implicated in acute and chronic inflammatory diseases. This study investigated the role of the MIF-GC regulatory dyad in the expression and release of matrix metalloproteinase-2 (MMP-2) during periodontitis, in vivo and in vitro. In a Mif-knockout (KO) mouse model of ligature-induced periodontitis, gingival tissues and blood were collected and analysed for levels of interleukin-6 (IL-6), MIF, MMP-2, and corticosterone...
October 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28768722/macrophage-migration-inhibitory-factor-enhances-pseudomonas-aeruginosa-biofilm-formation-potentially-contributing-to-cystic-fibrosis-pathogenesis
#19
Aisling Tynan, Leona Mawhinney, Michelle E Armstrong, Ciaran O'Reilly, Sarah Kennedy, Emma Caraher, Karen Jülicher, David O'Dwyer, Lewena Maher, Kirsten Schaffer, Aurélie Fabre, Edward F McKone, Lin Leng, Richard Bucala, Jürgen Bernhagen, Gordon Cooke, Seamas C Donnelly
Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator that we have previously shown to be associated with an aggressive clinical phenotype in cystic fibrosis. It possesses unique tautomerase enzymatic activity. However, to date, no human-derived substrate has been identified that has the capacity to interact with this cytokine's unique tautomerase activity. This led us to hypothesize that MIF may have the capacity to interact with external substrates. We describe for the first time how Pseudomonas aeruginosa can utilize human recombinant MIF (rMIF) to significantly (P < 0...
August 2, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28753101/salivary-and-serum-markers-related-to-innate-immunity-in-generalized-aggressive-periodontitis
#20
Ronaldo Lira-Junior, Veli Özgen Öztürk, Gulnur Emingil, Nagihan Bostanci, Elisabeth Almer Boström
BACKGROUND: Host inflammatory and immune responses play an important role in aggressive periodontitis (AgP). Thus, this study aimed to evaluate the levels of the innate immunity-related markers calprotectin, colony-stimulating factor (CSF)-1, macrophage migration inhibitory factor (MIF), monokine induced by interferon-γ (MIG), and matrix metalloproteinase (MMP)-8 in serum and saliva from patients having generalized AgP and those having gingivitis or a healthy periodontium. METHODS: This study enrolled 40 individuals (23 females; mean age 33...
July 28, 2017: Journal of Periodontology
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