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"Macrophage Migration Inhibitory Factor"

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https://www.readbyqxmd.com/read/28199208/macrophage-migration-inhibitory-factor-sirna-inhibits-hepatic-metastases-of-colorectal-cancer-cells
#1
Li-Hao Wu, Harry Hua-Xiang Xia, Wei-Qing Ma, Hao-Jie Zhong, Hui-Xian Xu, Ya-Min Wang, Rong-Jiao Yang, Li-Jing Wang, Yu Chen, Lan Li, Xing-Xiang He
The purpose of this study was to assess the anti-tumor effects of macrophage migration inhibitory factor (MIF) siRNA on colorectal cancer in a mouse xenograft model. MIF specific siRNA (MIF siRNA) or a nonspecific control siRNA was introduced to murine colorectal cancer CT-26 cells. Mouse xenograft models of colorectal cancer were established. MIF siRNA, control siRNA or water was injected twice a week intravenously for 4 weeks. MIF siRNA inhibited the proliferation and migration, while induced apoptosis of CT-26 cells in vitro...
March 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28191280/macrophage-migration-inhibitory-factor-as-an-emerging-drug-target-to-regulate-antioxidant-response-element-system
#2
REVIEW
Hiroshi Yukitake, Masayuki Takizawa, Haruhide Kimura
Oxidative stress is involved in pathophysiology and pathological conditions of numerous human diseases. Thus, understanding the mechanisms underlying the redox homeostasis in cells and organs is valuable for discovery of therapeutic drugs for oxidative stress-related diseases. Recently, by applying chemical biology approach with an ARE activator, BTZO-1, we found macrophage migration inhibitory factor (MIF) as a new regulator of antioxidant response element- (ARE-) mediated gene transcription. BTZO-1 and its active derivatives bound to MIF and protected cells and organs from oxidative insults via ARE activation in animal models with oxidative stress such as ischemia/reperfusion injury, inflammatory bowel diseases, and septic shock...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28188039/inflammation-factors-in-hepatoblastoma-and-their-clinical-significance-as-diagnostic-and-prognostic-biomarkers
#3
Fei Guo, Qin Ru, Junjie Zhang, Shen He, Jiekai Yu, Shu Zheng, Jiaxiang Wang
PURPOSE: The aims of this study were to identify inflammation factors in hepatoblastoma tissue that correlated with different clinical characteristics, and to explore the probability as predictive biomarkers for diagnosis and prognosis. METHODS: SELDI-TOF-MS was performed to screen protein peaks that were significantly highly expressed in tumor tissue compared with adjacent liver tissue. After removing proteins larger than 30kDa, the targeted peaks were separated by solid phase extraction and tricine-SDS-PAGE...
February 1, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28186296/entamoeba-histolytica-encoded-homolog-of-macrophage-migration-inhibitory-factor-contributes-to-mucosal-inflammation-during-amebic-colitis
#4
Renay Ngobeni, Mayuresh M Abhyankar, Nona M Jiang, Laura A Farr, Amidou Samie, Rashidul Haque, Shannon N Moonah
No abstract text is available yet for this article.
February 10, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28179905/plasma-levels-of-macrophage-migration-inhibitory-factor-and-d-dopachrome-tautomerase-show-a-highly-specific-profile-in-early-life
#5
Thierry Roger, Luregn J Schlapbach, Anina Schneider, Manuela Weier, Sven Wellmann, Patrick Marquis, David Vermijlen, Fred C G J Sweep, Lin Leng, Richard Bucala, Thierry Calandra, Eric Giannoni
Macrophage migration inhibitory factor (MIF) is a pleiotropic, constitutively expressed, pro-inflammatory cytokine and an important regulator of immune responses. d-dopachrome tautomerase (DDT), a newly described member of the MIF protein superfamily, shares sequence homology and biological activities with MIF. We recently reported that high expression levels of MIF sustain innate immune responses in newborns. Here, we elected to further characterize age-dependent MIF expression and to define whether DDT shares a similar expression profile with MIF...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28177603/pro-inflammatory-and-pro-fibrogenic-effects-of-ionic-and-particulate-arsenide-and-indium-containing-semiconductor-materials-in-the-murine-lung
#6
Wen Jiang, Xiang Wang, Olivia J Osborne, Yingjie Du, Chong Hyun Chang, Yu-Pei Liao, Bingbing Sun, Jinhong Jiang, Zhaoxia Ji, Ruibin Li, Xiangsheng Liu, Jianqin Lu, Sijie Lin, Huan Meng, Tian Xia, André E Nel
We have recently shown that the toxicological potential of GaAs and InAs particulates in cells is size- and dissolution-dependent, tending to be more pronounced for nano- vs micron-sized particles. Whether the size-dependent dissolution and shedding of ionic III-V materials also apply to pulmonary exposure is unclear. While it has been demonstrated that micron-sized III-V particles, such as GaAs and InAs, are capable of inducing hazardous pulmonary effects in an occupational setting as well as in animal studies, the effect of submicron particles (e...
February 8, 2017: ACS Nano
https://www.readbyqxmd.com/read/28165114/macrophage-migration-inhibitory-factor-triggers-vascular-smooth-muscle-cell-dedifferentiation-by-a-p68-serum-response-factor-axis
#7
Ye Fan, Jing Zhang, Cai-Yu Chen, Ying-Bin Xiao, Laureano D Asico, Pedro A Jose, Jian-Cheng Xu, Gui-Sheng Qian, Chun-Yu Zeng
No abstract text is available yet for this article.
February 6, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28161708/alterations-of-macrophage-migration-inhibitory-factor-expression-in-the-nervous-system-of-the-rat-cystitis-model
#8
Kwang Woo Lee, Woong Bin Kim, Sang Wook Lee, Jae Heon Kim, Jun Mo Kim, Young Ho Kim, Min Eui Kim
OBJECTIVE: We evaluated the changes in the migration inhibitory factor (MIF) expression with time in the bladder and spinal cord of a Sprague-Dawley rat cystitis model. METHODS: The bladder created by injecting lipopolysaccharide (LPS) and the lumbosacral spinal cord were removed at 4, 24, and 48 h, and 7 days after the induction of chronic cystitis, and 24 h after the induction of acute cystitis. The MIF expression was estimated using immunohistochemical staining, and the MIF mRNA was quantitatively analyzed using real-time polymerase chain reaction...
February 4, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28160516/macrophage-migration-inhibitory-factor-promoter-polymorphisms-794catt5-7-as-potential-biomarker-for-early-stage-cervical-cancer
#9
Suhui Wu, Jingfen Sun, Junfang Lian, Haixia Shang, Huijuan Tao, Jun Xie, Weifeng Lin
AIM: The objective was to investigate the correlation between macrophage migration inhibitory factor (MIF) promoter polymorphisms (-794CATT5-7 ) and early-stage cervical cancer (ESCC) and to identify a potential biomarker for ESCC. METHODS: A hospital-based case-control study was performed. The case group contained 250 patients with histologically confirmed ESCC. The control group included 147 healthy women. Polymerase chain reaction-single strand conformation polymorphism was used to genotype polymorphisms of MIF promoter -794CATT5-7 ...
February 4, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28158469/increased-expression-of-macrophage-migration-inhibitory-factor-in-the-nucleus-of-the-solitary-tract-attenuates-renovascular-hypertension-in-rats
#10
Rafaela Moreira Barbosa, Guilherme F Speretta, Daniel Penteado Martins Dias, Prashant Jay Ruchaya, Hongwei Li, José Vanderlei Menani, Colin Sumners, Eduardo Colombari, Débora S A Colombari
No abstract text is available yet for this article.
January 31, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28151558/whole-transcriptome-sequencing-identifies-increased-cxcr2-expression-in-pnh-granulocytes
#11
Kohei Hosokawa, Sachiko Kajigaya, Keyvan Keyvanfar, Wangmin Qiao, Yanling Xie, Angelique Biancotto, Danielle M Townsley, Xingmin Feng, Neal S Young
The aetiology of paroxysmal nocturnal haemoglobinuria (PNH) is a somatic mutation in the X-linked phosphatidylinositol glycan class A gene (PIGA), resulting in global deficiency of glycosyl phosphatidylinositol-anchored proteins (GPI-APs). This study applied RNA-sequencing to examine functional effects of the PIGA mutation in human granulocytes. CXCR2 expression was increased in GPI-AP(-) compared to GPI-AP(+) granulocytes. Macrophage migration inhibitory factor, a CXCR2 agonist, was significantly higher in plasma of PNH patients...
February 1, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28146458/moderate-hyperoxia-induces-inflammation-apoptosis-and-necrosis-in-human-umbilical-vein-endothelial-cells-an-in-vitro-study
#12
Christina Hafner, Jing Wu, Lourdes Soto-Gonzalez, Christoph Kaun, Stefan Stojkovic, Johann Wojta, Verena Tretter, Klaus Markstaller, Klaus U Klein
BACKGROUND: Perioperative oxygen (O2) therapy can cause hyperoxia. Extreme hyperoxia can injure the cardiovascular system and remote organs. OBJECTIVE: Our primary objective was to test the hypothesis that exposure to moderate hyperoxia will induce injury to human umbilical vein endothelial cells (HUVECs), a model for studying the vascular endothelium under controlled conditions. DESIGN: In-vitro cell culture study. SETTING: Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Austria...
March 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28105287/systematic-study-of-effects-of-structural-modifications-on-the-aqueous-solubility-of-drug-like-molecules
#13
José A Cisneros, Michael J Robertson, Brandon Q Mercado, William L Jorgensen
Aqueous solubilities and activities have been measured for 17 members of the quinolinyltriazole series of inhibitors of human macrophage migration inhibitory factor (MIF). Systematic variation of a solvent-exposed substituent provided increases in solubility from 2 μg/mL for the parent compound 3a up to 867 μg/mL. The low solubility of 3a results from its near-planar structure and an intermolecular hydrogen bond, as revealed in a small-molecule X-ray structure. Removal of the hydrogen bond yields a 3-fold increase in solubility, but a 7-fold drop in activity...
January 12, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28092336/the-construction-of-expanded-prefabricated-adipose-tissue-epat-using-an-external-volume-expansion-eve-device
#14
Yi Yuan, Shuifa Yang, Yangyan Yi, Jianhua Gao, Feng Lu
BACKGROUND: Multiple studies have demonstrated that mechanical forces promote the growth of adipose tissue. However, the mechanism of adipose tissue regeneration induced by mechanical forces remains unclear. METHODS: In an experiment using rats, prefabricated adipose tissue with a vessel pedicle was expanded using an external volume expansion (EVE) device. The volume of fat flaps was tested at different time points. Cell proliferation and angiogenesis were analyzed using immunofluorescence...
January 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28091532/development-of-the-neuroimmune-modulator-ibudilast-for-the-treatment-of-alcoholism-a-randomized-placebo-controlled-human-laboratory-trial
#15
Lara A Ray, Spencer Bujarski, Steve Shoptaw, Daniel Jo Roche, Keith Heinzerling, Karen Miotto
Current directions in medication development for alcohol use disorder (AUD) emphasize the need to identify novel molecular targets and efficiently screen new compounds aimed at those targets. Ibudilast (IBUD) is a neuroimmune modulator that inhibits phosphodiesterases -4 and -10 and macrophage migration inhibitory factor and was recently found to reduce alcohol intake in rats by approximately 50%. To advance medications development for AUD, the present study consists of a randomized, crossover, double-blind, placebo-controlled laboratory study of IBUD in non-treatment seeking individuals with current (ie, past month) mild-to-severe AUD...
January 16, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28090291/macrophage-migration-inhibitory-factor-as-a-novel-biomarker-of-portopulmonary-hypertension
#16
Hilary M DuBrock, Josanna M Rodriguez-Lopez, Barbara L LeVarge, Michael P Curry, Paul A VanderLaan, Zsuzsanna K Zsengeller, Elizabeth Pernicone, Ioana R Preston, Paul B Yu, Ivana Nikolic, Dihua Xu, Ravi I Thadhani, Richard N Channick, S Ananth Karumanchi
Portopulmonary hypertension (POPH) is a poorly understood complication of liver disease associated with significant morbidity and mortality. We sought to identify novel biomarkers of POPH disease presence and severity. We performed a prospective, multicenter, case-control study involving patients with liver disease undergoing right heart catheterization. POPH cases were defined as a mean pulmonary arterial pressure (mPAP) ≥25 mmHg and pulmonary vascular resistance (PVR) >240 dynes˙s˙cm(-5). Plasma samples were collected from the systemic and pulmonary circulation, and antibody microarray was used to identify biomarkers...
December 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/28070752/absence-of-macrophage-migration-inhibitory-factor-reduces-proliferative-retinopathy-in-a-mouse-model
#17
Jing Wang, Jihong Lin, Ulrike Kaiser, Paulus Wohlfart, Hans-Peter Hammes
AIMS: Ischemia-induced neovascularization is the key feature of proliferative diabetic retinopathy. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory and proangiogenic cytokine, and its levels are elevated in the vitreous of patients with proliferative diabetic retinopathy. In this study, we aimed at investigating the relative potential of MIF in the ischemia-induced retinal neovascularization. METHODS: Both WT and MIF-knockout mice were subjected to the retinopathy of prematurity (ROP) model...
January 9, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28064059/par1-activation-affects-the-neurotrophic-properties-of-schwann-cells
#18
Elena Pompili, Cinzia Fabrizi, Francesca Somma, Virginia Correani, Bruno Maras, Maria Eugenia Schininà, Viviana Ciraci, Marco Artico, Francesco Fornai, Lorenzo Fumagalli
Protease-activated receptor-1 (PAR1) is the prototypic member of a family of four G-protein-coupled receptors that signal in response to extracellular proteases. In the peripheral nervous system, the expression and/or the role of PARs are still poorly investigated. High PAR1 mRNA expression was found in the rat dorsal root ganglia and the signal intensity of PAR1 mRNA increased in response to sciatic nerve transection. In the sciatic nerve, functional PAR1 receptor was reported at the level of non-compacted Schwann cell myelin microvilli of the nodes of Ranvier...
January 4, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28044966/-macrophage-migration-inhibitory-factor-mif-a-regulator-of-neonatal-innate-immune-response
#19
Éric Giannoni, Anina Schneider, Thierry Calandra, Thierry Roger
No abstract text is available yet for this article.
December 2016: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28031488/cd74-is-a-novel-transcription-regulator
#20
Naama Gil-Yarom, Lihi Radomir, Lital Sever, Matthias P Kramer, Hadas Lewinsky, Chamutal Bornstein, Ronnie Blecher-Gonen, Zohar Barnett-Itzhaki, Vita Mirkin, Gilgi Friedlander, Lev Shvidel, Yair Herishanu, Elias J Lolis, Shirly Becker-Herman, Ido Amit, Idit Shachar
CD74 is a cell-surface receptor for the cytokine macrophage migration inhibitory factor. Macrophage migration inhibitory factor binding to CD74 induces its intramembrane cleavage and the release of its cytosolic intracellular domain (CD74-ICD), which regulates cell survival. In the present study, we characterized the transcriptional activity of CD74-ICD in chronic lymphocytic B cells. We show that following CD74 activation, CD74-ICD interacts with the transcription factors RUNX (Runt related transcription factor) and NF-κB and binds to proximal and distal regulatory sites enriched for genes involved in apoptosis, immune response, and cell migration...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
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