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Barbora Dousova, Miloslav Lhotka, Jan Filip, David Kolousek
Iron impurities in clays degrade the quality in many aspects, but available Fe oxides can significantly improve adsorption affinity of clays to anionic particles. Two natural Fe-rich clays (kaolin and bentonite) were treated in 0.5 M HCl (pH = 1.1) and 0.15 M (COOH)2 (pH = 1.2), and then used to adsorb AsV /SbV oxyanions from model solutions. After acid leaching, the equilibrium sorption capacities (qmax ) increased from 2.3 × 10-3 to 39.2 × 10-3  mmol g-1 for AsV and from 2.4 × 10-3 to 40...
June 12, 2018: Journal of Hazardous Materials
Yuji Teraoka, Takuro Uchida, Michio Imamura, Nobuhiko Hiraga, Mitsutaka Osawa, Hiromi Kan, Yuhei Saito, Masataka Tsuge, Hiromi Abe-Chayama, C Nelson Hayes, Grace Naswa Makokha, Hiroshi Aikata, Daiki Miki, Hidenori Ochi, Yuji Ishida, Chise Tateno, Kazuaki Chayama
Combined daclatasvir (DCV)/asunaprevir (ASV) plus beclabuvir (BCV) treatment shows a high virological response for genotype 1b chronic hepatitis C patients. However, its efficacy for patients for whom previous direct-acting antiviral (DAA) therapy failed is not known. We analysed the efficacy of DCV/ASV/BCV treatment for HCV-infected mice and chronic hepatitis patients. Human hepatocyte chimaeric mice were injected with serum samples obtained from either a DAA-naïve patient or a DCV/ASV treatment failure and were then treated with DCV/ASV alone or in combination with BCV for 4 weeks...
June 19, 2018: Journal of General Virology
Melissa A Daubert, David J Whellan, Holger Woehrle, Gudaye Tasissa, Kevin J Anstrom, JoAnn Lindenfeld, Adam Benjafield, Amy Blase, Naresh Punjabi, Mona Fiuzat, Olaf Oldenburg, Christopher M O'Connor
BACKGROUND: Sleep-disordered breathing (SDB), including central and obstructive sleep apnea, is a marker of poor prognosis in heart failure (HF) and may worsen cardiac dysfunction over time. Treatment of SDB with adaptive servoventilation (ASV) may reverse pathologic cardiac remodeling in HF patients. METHODS: The Cardiovascular Improvements with Minute Ventilation-targeted Adaptive Servo-Ventilation Therapy in Heart Failure (CAT-HF) trial randomized patients with acute decompensated HF and confirmed SDB to either optimal medical therapy (OMT) or treatment with ASV and OMT...
July 2018: American Heart Journal
Jawad S Hussain, Ravi N Srinivasa, Anthony Hage, Rudra Pampati, Jeffrey Forris Beecham Chick
SASI (selective arterial secretin injection) is a form of ASVS (arterial stimulation and venous sampling) used to localize pancreatic gastrinomas. This report aims to review the protocol for SASI and demonstrate its utility in localizing functional and nonfunctional gastrinomas. Even if a patient has a pancreatic mass and a laboratory profile fitting a specific endocrine syndrome, these may or may not be associated as has been previously demonstrated with adrenal vein sampling. We present a case where a patient underwent simultaneous SASI and bland embolization of a hepatic metastasis to facilitate partial pancreatectomy for Zollinger-Ellison syndrome...
April 2018: Radiology Case Reports
Fumitaka Suzuki, Naoya Hatanaka, Etsuya Bando, Koji Nakamura, Akira Komoto
BACKGROUND: Safety and effectiveness of daclatasvir (DCV)/asunaprevir (ASV) dual therapy were demonstrated in Japanese patients with chronic hepatitis C (CHC) genotype (GT) 1b in phase III studies. This postmarketing surveillance (PMS) was conducted to assess the safety and effectiveness of DCV/ASV in Japanese patients with GT-1 CHC treated in routine clinical practice. METHODS: This PMS was conducted between September 2014 and February 2017 at 261 centers in Japan...
May 2018: Hepatology International
Tasneem Gul Kazi, Kapil Dev Brahman, Jameel Ahmed Baig, Hassan Imran Afridi
The contaminated groundwater is one of emerging environmental issue in Pakistan and biosorbent considered to be the best alternative to improve the quality of groundwater. Thus, an indigenous biosorbent, Cucumis pubescens (peel of fruit) has been carried out efficiently for simultaneous removal of arsenic species and fluoride from groundwater. The characterization of bio-sorbent for removal of As species (AsIII , AsV ) and F- was studied by FTIR spectroscopy and SEM. Batch experiments were carried out for the optimization of adsorption capacity at different parameters such as pH (3-11), concentration of biosorbates (100-500 μg/L) for As species and F- ion), biosorbent dose (2-6 g/L), contact time (10-60 min) and temperature (303-323 K)...
June 1, 2018: Journal of Hazardous Materials
Virend Somers, Michael Arzt, T Douglas Bradley, Winfried Randerath, Renaud Tamisier, Christine Won
As seen in this CME online activity (available at, central sleep apnea (CSA) is associated with increased mortality in patients with heart failure (HF), and it has been thought that treatment of CSA may improve underlying HF. Positive airway pressure therapy, specifically auto-servoventilation (ASV), can not only suppress abnormal breathing patterns but has been reported to improve cardiac function in HF patients with CSA. In patients with HF and with CSA unsuppressed with CPAP, newer ASV use has been associated with significant CSA improvement; in addition, several studies have reported efficacy of ASV in the treatment of underlying cardiac dysfunction in HF patients with CSA...
June 2018: Chest
Teruhiko Imamura, Koichiro Kinugawa
Clinical advantages in the adaptive servo-ventilation (ASV) therapy have been reported in selected heart failure patients with/without sleep-disorder breathing, whereas multicenter randomized control trials could not demonstrate such advantages. Considering this discrepancy, optimal patient selection and device setting may be a key for the successful ASV therapy. Hemodynamic and echocardiographic parameters indicating pulmonary congestion such as elevated pulmonary capillary wedge pressure were reported as predictors of good response to ASV therapy...
May 23, 2018: International Heart Journal
Jae Young Oh, Byung Seok Kim, Chang Hyeong Lee, Jeong Eun Song, Heon Ju Lee, Jung Gil Park, Jae Seok Hwang, Woo Jin Chung, Byoung Kuk Jang, Young Oh Kweon, Won Young Tak, Soo Young Park, Se Young Jang, Jeong Ill Suh, Sang Gyu Kwak
Background/Aims: Previous studies have reported a high rate of sustained virologic response (SVR) and a low rate of serious adverse events with the use of daclatasvir (DCV) and asunaprevir (ASV) combination therapy. We evaluated the efficacy and safety of DCV and ASV combination therapy for patients with chronic hepatitis C virus (HCV) genotype 1b infection in real world. Methods: We enrolled 278 patients (184 treatment-naïve patients) from five hospitals in Daegu and Gyeongsangbuk-do...
May 25, 2018: Korean Journal of Internal Medicine
Afsha Aurshina, Ahmad Alsheekh, Pavel Kibrik, Anil Hingorani, Natalie Marks, Enrico Ascher
OBJECTIVE: Endovenous thermal ablation in the form of radiofrequency ablation (RFA) or endovenous laser ablation (EVLA) has quickly ascended to a prime position in the treatment of venous insufficiency. While there is good data examining the rates of thrombotic complications, there is a relative paucity of data examining the recanalization rates after endovenous thermal ablation (ETA). METHODS: Data analysis was performed for 1475 thermal ablations in 485 patients from 2012-2015 as a retrospective chart review...
May 16, 2018: Annals of Vascular Surgery
Yechan Jeong, Bora Jin, Hye Won Lee, Hye Jung Park, Jun Yong Park, Do Young Kim, Kwang-Hyub Han, Sang Hoon Ahn, Seungtaek Kim
Daclatasvir plus asunaprevir (DCV+ASV) treatment is an all-oral direct-acting antiviral (DAA) therapy for the genotype 1b HCV-infected patients. In this study, we investigated how resistance-associated substitutions (RASs) evolved after treatment failures and assessed the effect of those substitutions on viral fitness. Sequencing of NS5A and NS3 revealed typical RASs after treatment failures. Interestingly, the RASs of NS3 reverted to the wild-type amino acid within one year after treatment failures. However, the RASs of NS5A were stable and did not change...
May 16, 2018: Journal of Viral Hepatitis
Zhuanxi Luo, Mengting Li, Zhenhong Wang, Jinli Li, Jianhua Guo, Ricki R Rosenfeldt, Frank Seitz, Changzhou Yan
The impact of titanium dioxide nanoparticles (nano-TiO2 ) on the bioavailability of metals in aquatic filter-feeding organisms has rarely been investigated, especially in the presence of algae as a food source. In this study, we quantified the accumulation and subcellular distribution of arsenate (AsV ) in Daphnia magna in the presence of nano-TiO2 and a green alga (Scenedesmus obliquus) food source. Results showed that S. obliquus significantly increased the accumulation of total arsenic (As) and titanium (Ti) in D...
May 15, 2018: Environmental Science and Pollution Research International
Liuyang Zhang, Jinju Luo, Xinyu Shen, Chunya Li, Xian Wang, Bei Nie, Huaifang Fang
Direct detecting of trace amount Al(III) in aqueous solution by stripping voltammetry is often frustrated by its irreversible reduction, resided at −1.75 V (vs. Ag/AgCl reference), which is in a proximal potential of proton reduction. Here, we described an electroanalytical approach, combined with liquid phase microextraction (LPME) using ionic liquid (IL), to quantitatively assess trace amount aluminum in environmental samples. The Al(III) was caged by 8-hydroxyquinoline, forming a superb hydrophobic metal⁻chelate, which sequentially transfers and concentrates in the bottom layer of IL-phase during LPME...
May 10, 2018: Sensors
Takaaki Nakamoto
Sleep-disordered breathing (SDB) is a risk factor for cardiovascular disease including acute coronary syndrome and acute myocardial infarction, and treating SDB prevents their development and recurrence and improves a patient's prognosis. Therefore, SDB is considered a therapeutic target for cardiovascular disease. In 2010, the Japanese Circulation Society published guidelines for the diagnosis and treatment of SDB in patients with cardiovascular disease. However, therapeutic intervention for patients with SDB was recently reported not to suppress the development or deterioration of cardiovascular disease in three middle- to large-sized randomized clinical trials: the SERVE-HF trial, which examined the effects of adaptive servo-ventilation (ASV) on patients with chronic heart failure (CHF) and central sleep apnea; the CAT-HF trial, which examined the effects of ASV therapy on patients with CHF after acute deterioration; and the SAVE study, which examined the secondary preventive effect of continuous positive airway pressure (CPAP) on patients with ischemic heart disease who had mild to moderate obstructive sleep apnea...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Laura Barral-Fraga, Diego Martiñá-Prieto, María Teresa Barral, Soizic Morin, Helena Guasch
Gold mining activities in fluvial systems may cause arsenic (As) pollution, as is the case at the Anllóns River (Galicia, NW Spain), where high concentrations of arsenate (AsV ) in surface sediments (up to 270 mg kg-1 ) were found. A 51 day-long biofilm-translocation experiment was performed in this river, moving some biofilm-colonized substrata from upstream (less As-polluted) to downstream the mine area (more As-polluted site), to explore the effect of As on benthic biofilms, as well as their role on As retention and speciation in the water-sediment interface...
May 2, 2018: Science of the Total Environment
Katarzyna Pazdro-Zastawny, Lucyna Pośpiech, Tomasz Zatoński
BACKGROUND: Otitis media with effusion (OME) is one of the most common clinical conditions in childhood. Fluid accumulation in the middle ear may impact inner ear. OBJECTIVES: The purpose of this random sample cohort study was to investigate whether the past history of middle ear effusion has a long-term negative impact on the vestibular system in children. MATERIAL AND METHODS: The study was carried out on 22 children aged 7-15 years who had undergone drainage of the middle ear 5 years before evaluation...
June 2018: International Journal of Pediatric Otorhinolaryngology
Ning Ding, Xilong Zhang
Central sleep apnea (CSA) is common in heart failure (HF) patients. Traditional treatment of CSA, including continuous positive airway pressure (CPAP), adaptive servo ventilation (ASV), oxygen therapy, and CO2 inhalation, has respective limitations. Transvenous phrenic nerve stimulation (PNS), a novel therapeutic approach for CSA, was proved to be effective and safe. The remedē® system and related transvenous PNS methods was approved by FDA in 2017, for treating moderate to severe CSA.
March 2018: Journal of Thoracic Disease
Lian-Xian Guo, Gui-Wei Zhang, Jia-Ting Wang, Yue-Ping Zhong, Zhi-Gang Huang
This study sought to determine the concentration and distribution of arsenic (As) species in Ophiocordyceps sinensis ( O. sinensis ), and to assess its edible hazard for long term consumption. The total arsenic concentrations, measured through inductively coupled plasma mass spectrometry (ICP-MS), ranged from 4.00 mg/kg to 5.25 mg/kg. As determined by HPLC-ICP-MS, the most concerning arsenic species—AsB, MMAV , DMAV , AsV , and AsШ —were either not detected (MMAV and DMAV ) or were detected as minor As species (AsB: 1...
April 26, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
A Ruttens, K Cheyns, A C Blanpain, L De Temmerman, N Waegeneers
This study reports results of total arsenic (Astot ) and various As species in 75 samples of cereals and cereal products bought on the Belgian market. In addition to rice, the samples were wheat, pasta, bread and some breakfast cereals. The inorganic species arsenite (AsIII ) and arsenate (AsV ), and the organic As compounds dimethyl arsinate (DMA) and monomethyl arsonate (MA) were the only As species detected. Mean Astot was 0.150 ± 0.089 mg kg-1 in rice and 0.012 ± 0.008 mg kg- in the non-rice cereals...
April 22, 2018: Food and Chemical Toxicology
Karen Leus, Karel Folens, Nina Ricci Nicomel, Jeffrey Paulo H Perez, Maria Filippousi, Maria Meledina, Marinela M Dîrtu, Stuart Turner, Gustaaf Van Tendeloo, Yann Garcia, Gijs Du Laing, Pascal Van Der Voort
The covalent triazine framework, CTF-1, served as host material for the in situ synthesis of Fe2 O3 nanoparticles. The composite material consisted of 20 ± 2 m% iron, mainly in γ-Fe2 O3 phase. The resulting γ-Fe2 O3 @CTF-1 was examined for the adsorption of AsIII , AsV and HgII from synthetic solutions and real surface-, ground- and wastewater. The material shows excellent removal efficiencies, independent from the presence of Ca2+ , Mg2+ or natural organic matter and only limited dependency on the presence of phosphate ions...
April 16, 2018: Journal of Hazardous Materials
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