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https://www.readbyqxmd.com/read/28224905/emerging-trends-in-biosensing-using-stripping-voltammetric-detection-of-metal-containing-nanolabels-a-review
#1
REVIEW
Christos Kokkinos, Anastasios Economou
Over the last years, nanomaterials have found many applications in the development of electrochemical biosensors. Among other functions, metal nanoparticles (NPs) and quantum dots (QDs) (semiconducting nanocrystals composed of metal salts) are increasingly being used as voltammetric labels in affinity biosensing. Labeling is based on the attachment of the label(s) on the target biomolecules or on a biorecognition reporting probe. After an appropriate specific affinity interaction between the target and the reporting probe, the metallic nanolabels are converted to the respective cations which are quantified by a voltammetric technique...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28210325/hot-topics-from-the-assemblies
#2
(no author information available yet)
Cowie et al. present the results of the international, multicentre, randomised, parallel-group SERVE-HF (Treatment of sleep-disordered breathing with predominant central sleep apnea by adaptive servo ventilation in patients with heart failure) trial, which investigated the effects of adding adaptive servo-ventilation (ASV) to guideline based medical management on survival and cardiovascular outcomes in patients with heart failure defined as reduced ejection fraction (<45%) and predominant central sleep apnoea (CSA)...
December 2016: Breathe
https://www.readbyqxmd.com/read/28198026/quantitative-assessment-of-haemolysis-secondary-to-modern-infusion-pumps
#3
T G Poder, J-C Boileau, R Lafrenière, L Thibault, N Carrier, M-J de Grandmont, P Beauregard
BACKGROUND: Although most studies have shown that little haemolysis is induced by infusion pumps, there are some notable exceptions. Only limited data are available on the actual infusion pumps that are most used in hospitals in Quebec and elsewhere, namely, the Infusomat(®) Space (peristaltic), Plum A+™ (piston) and Colleague(®) CXE (shuttle) pumps. METHODS: Haemolysis and potassium levels were compared before and after the use of the three different infusion pumps...
February 15, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28188451/patients-with-cheyne-stokes-respiration-and-heart-failure-patient-tolerance-after-three-month-discontinuation-of-treatment-with-adaptive-servo-ventilation
#4
Arild Hetland, Tøri Vigeland Lerum, Kristina H Haugaa, Thor Edvardsen
The recent SERVE HF study concluded that patients with chronic heart failure (CHF) and Cheyne-Stokes respiration (CSR) have increased mortality when treated with adaptive servo-ventilation (ASV). We, therefore, wanted to explore if these patients tolerated discontinuation of ASV treatment. The study was a prospective post-ASV treatment observational design with a 3-month follow-up period. 14 patients from our outpatient clinic, all male, were originally diagnosed with CHF and Cheyne-Stokes respiration, which is a clinical form of central sleep apnea...
February 11, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28178397/the-efficacy-and-safety-of-dual-oral-therapy-with-daclatasvir-and-asunaprevir-for-genotype-1b-in-japanese-real-life-settings
#5
Hitomi Sezaki, Fumitaka Suzuki, Tetsuya Hosaka, Norio Akuta, Shunichiro Fujiyama, Yusuke Kawamura, Masahiro Kobayashi, Yoshiyuki Suzuki, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi, Hiromitsu Kumada
BACKGROUND & AIMS: It is important to investigate the treatment outcomes in patients excluded from clinical trials (CTR). The aims of this study were to evaluate the efficacy and safety of a 24-week daclatasvir (DCV) and asunaprevir (ASV) therapy for patients with chronic hepatitis C virus (HCV)-1b infection. METHODS: 651 HCV-1b patients started dual oral therapy with DCV and ASV for 24 weeks in Toranomon Hospital, Tokyo. Among them, 276 patients met phase III-CTR inclusion criteria...
February 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28155765/-initiatives-in-urban-health-communities-health-promotion-at-work-in-deprived-territories
#6
Clémentine Motard, Stéphane Tessier
<ce:para>The “Urban Health Workshop” [“Atelier santé ville” (Asv)] approach, created in 2000 and interfacing between urban development policies and public health, is implemented in about 250 territories. After more than fifteen years of implementation and development, it appeared useful to review experiences and analyse their effects.</ce:para><ce:para>Conducted in 2015, this research demonstrates the benefits of Asv, which created health territorial dynamics and local strategies to reduce social and territorial health inequalities...
December 19, 2016: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28134353/baseline-quasispecies-selection-and-novel-mutations-contribute-to-emerging-resistance-associated-substitutions-in-hepatitis-c-virus-after-direct-acting-antiviral-treatment
#7
Yugo Kai, Hayato Hikita, Naoki Morishita, Kazuhiro Murai, Tasuku Nakabori, Sadaharu Iio, Hideki Hagiwara, Yasuharu Imai, Shinji Tamura, Syusaku Tsutsui, Masafumi Naito, Meiko Nishiuchi, Yasuteru Kondo, Takanobu Kato, Hiroshi Suemizu, Ryoko Yamada, Tsugiko Oze, Takayuki Yakushijin, Naoki Hiramatsu, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
Resistance-associated substitutions (RASs) in hepatitis C virus (HCV) appear upon failure of treatment with direct-acting antivirals (DAAs). However, their origin has not been clarified in detail. Among 11 HCV genotype 1b patients who experienced virologic failure with asunaprevir (ASV)/daclatasvir (DCV), 10 had major NS5A L31M/V-Y93H variants after treatment. L31M/V-Y93H variants were detected as a minor clone before therapy in 6 patients and were the most closely related to the post-treatment variants by phylogenetic tree analysis in 4 patients...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28118381/clinical-significance-of-two-real-time-pcr-assays-for-chronic-hepatitis-c-patients-receiving-protease-inhibitor-based-therapy
#8
Takako Inoue, Su Su Hmwe, Noritomo Shimada, Keizo Kato, Tatsuya Ide, Takuji Torimura, Takashi Kumada, Hidenori Toyoda, Akihito Tsubota, Koichi Takaguchi, Takaji Wakita, Yasuhito Tanaka
The aim of this study was to determine the efficacy of two hepatitis C virus (HCV) real-time PCR assays, the COBAS AmpliPrep/COBAS TaqMan HCV test (CAP/CTM) and the Abbott RealTime HCV test (ART), for predicting the clinical outcomes of patients infected with HCV who received telaprevir (TVR)-based triple therapy or daclatasvir/asunaprevir (DCV/ASV) dual therapy. The rapid virological response rates in patients receiving TVR-based triple therapy were 92% (23/25) and 40% (10/25) for CAP/CTM and ART, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28108165/microbial-siderophores-and-root-exudates-enhanced-goethite-dissolution-and-fe-as-uptake-by-as-hyperaccumulator-pteris-vittata
#9
Xue Liu, Jing-Wei Fu, Evandro Da Silva, Xiao-Xia Shi, Yue Cao, Bala Rathinasabapathi, Yanshan Chen, Lena Q Ma
Arsenic (As) in soils is often adsorbed on Fe-(hydro)oxides surface, rendering them more resistant to dissolution, which is undesirable for phytoremediation of As-contaminated soils. Arsenic hyperaccumulator Pteris vittata prefers to grow in calcareous soils where available Fe and As are low. To elucidate its mechanisms of acquiring Fe and As from insoluble sources in soils, we investigated dissolution of goethite with pre-adsorbed arsenate (AsV; As-goethite) in presence of four organic ligands, including two root exudates (oxalate and phytate, dominant in P...
January 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28090038/combination-therapy-with-ombitasvir-paritaprevir-ritonavir-for-dialysis-patients-infected-with-hepatitis-c-virus-a-prospective-multi-institutional-study
#10
Ken Sato, Kenichi Hosonuma, Yuichi Yamazaki, Takeshi Kobayashi, Satoshi Takakusagi, Norio Horiguchi, Satoru Kakizaki, Motoyasu Kusano, Hiroshi Ohnishi, Hiroaki Okamoto, Masanobu Yamada
Hepatitis C virus (HCV) infection is common in dialysis patients worldwide and nosocomial HCV spread within dialysis facilities continues to develop. Combination therapy with daclatasvir and asunaprevir (DCV/ASV) that has proven efficacy for dialysis patients infected with genotype 1b HCV (HCV/1b) has several concerns in Japan. The recently available combination therapy with ombitasvir, paritaprevir, and ritonavir (OBV/PTV/r) is not contraindicated in patients with chronic renal failure and has more safety profile and shorter treatment period than that with DCV/ASV...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28078469/new-resistance-associated-substitutions-and-failure-of-dual-oral-therapy-with-daclatasvir-and-asunaprevir
#11
Seiichi Mawatari, Kohei Oda, Kazuaki Tabu, Sho Ijuin, Kotaro Kumagai, Yukiko Inada, Hirofumi Uto, Yasunari Hiramine, Takeshi Kure, Kunio Fujisaki, Masafumi Hashiguchi, Takeshi Hori, Akihiko Oshige, Dai Imanaka, Akiko Saishoji, Oki Taniyama, Haruka Sakae, Tsutomu Tamai, Akihiro Moriuchi, Akio Ido
BACKGROUND: Daclatasvir (DCV) and asunaprevir (ASV) combination therapy has been primarily used in patients without NS5A L31 or Y93 resistance-associated substitutions (RASs) before treatment. We examined the characteristics of patients without these baseline RASs who did not achieve hepatitis C virus eradication with DCV and ASV combination therapy and identified new baseline NS5A RASs that are closely associated with failure of combination therapy. METHODS: Three hundred thirty-five patients with hepatitis C virus genotype 1 infection with no NS5A L31, NS5A Y93, and NS3 D168 RASs before DCV and ASV combination therapy and no history of protease inhibitor therapy were enrolled...
January 11, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28071239/induction-by-arsenate-of-cell-type-specific-cytotoxic-effects-in-nerve-and-hepatoma-cells
#12
Wafa Kharroubi, Thomas Nury, Samia Haj Ahmed, Pierre Andreoletti, Rachid Sakly, Mohamed Hammami, Gérard Lizard
The aim of the study was to compare the effect of sodium arsenate (AsV) on two different cell types: 158N murine oligodendrocytes and HepG2 human hepatoma cells. Exposure of 158N cells to AsV (0.1-400 µM; 48 h) induced a biphasic cytoxic effect defined as hormesis. Thus, low concentrations of AsV stimulate cell proliferation, as shown by phase-contrast microscopy, cell counting with trypan blue, and crystal violet assay, whereas high concentrations induce cell death associated with a loss of cell adhesion...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28056816/optimization-of-pressure-settings-during-adaptive-servo-ventilation-support-using-real-time-heart-rate-variability-assessment-initial-case-report
#13
Teruhiko Imamura, Daisuke Nitta, Koichiro Kinugawa
BACKGROUND: Adaptive servo-ventilation (ASV) therapy is a recent non-invasive positive pressure ventilation therapy that was developed for patients with heart failure (HF) refractory to optimal medical therapy. However, it is likely that ASV therapy at relatively higher pressure setting worsens some of the patients' prognosis compared with optimal medical therapy. Therefore, identification of optimal pressure settings of ASV therapy is warranted. CASE PRESENTATION: We present the case of a 42-year-old male with HF, which was caused by dilated cardiomyopathy, who was admitted to our institution for evaluating his eligibility for heart transplantation...
January 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28049871/identification-of-genotype-2-hcv-in-serotype-1-hepatitis-c-patients-unresponsive-to-daclatasvir-plus-asunaprevir-treatment
#14
Jun Inoue, Atsushi Kanno, Yuta Wakui, Masahito Miura, Tomoo Kobayashi, Tatsuki Morosawa, Takayuki Kogure, Eiji Kakazu, Masashi Ninomiya, Yasuyuki Fujisaka, Teruyuki Umetsu, Satoshi Takai, Takuya Nakamura, Tooru Shimosegawa
It is important to determine the genotypes or serotypes of hepatitis C virus (HCV) in patients before treatment with direct-acting antiviral agents (DAAs), because the effects of DAAs differ among genotypes. In Japan, two tests for HCV typing are available clinically, but only serotyping, not genotyping, is approved by the public health insurance. Although most serotype-1 Japanese patients are infected with genotype 1b HCV, it is known that a small proportion of patients show different results from two typing methods...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28039809/selective-staining-of-cds-on-zno-biolabel-for-ultrasensitive-sandwich-type-amperometric-immunoassay-of-human-heart-type-fatty-acid-binding-protein-and-immunoglobulin-g
#15
Xiaoli Qin, Aigui Xu, Ling Liu, Yuyun Sui, Yunlong Li, Yueming Tan, Chao Chen, Qingji Xie
We report on an ultrasensitive metal-labeled amperometric immunoassay of proteins, which is based on the selective staining of nanocrystalline cadmium sulfide (CdS) on ZnO nanocrystals and in-situ microliter-droplet anodic stripping voltammetry (ASV) detection on the immunoelectrode. Briefly, antibody 1 (Ab1), bovine serum albumin (BSA), antigen and ZnO-multiwalled carbon nanotubes (MWCNTs) labeled antibody 2 (Ab2-ZnO-MWCNTs) were successively anchored on a β-cyclodextrin-graphene sheets (CD-GS) nanocomposite modified glassy carbon electrode (GCE), forming a sandwich-type immunoelectrode (Ab2-ZnO-MWCNTs/antigen/BSA/Ab1/CD-GS/GCE)...
May 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28009965/chordal-shortening-for-anterior-mitral-leaflet-prolapse-and-the-maze-procedure-for-persistent-atrial-fibrillation
#16
Jong Hun Kim, Kyung Hwa Kim, Jong Bum Choi, Ja Hong Kuh
Letter to the Editor We read with great interest the report by Inoue et al. (Cusp-level chordal shortening for non-rheumatic mitralanterior leaflet prolapse in a patient with persistent atrial fibrillation. J Heart Valve Dis 2015;24:586-589) that described their mitral valve repair technique for anterior leaflet prolapse (ALP) and perioperative adaptive servo-ventilation (ASV) therapy for preventing the recurrence of atrial fibrillation after the maze procedure. Latent recurrence of atrial fibrillation after the maze procedure is caused by many factors...
July 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28002876/outcomes-of-treatment-with-daclatasvir-and-asunaprevir-for-recurrent-hepatitis-c-after-liver-transplantation
#17
Masaki Honda, Yasuhiko Sugawara, Takehisa Watanabe, Masakuni Tateyama, Motohiko Tanaka, Koushi Uchida, Seiichi Kawabata, Daiki Yoshii, Kouhei Miura, Kaori Isono, Shintaro Hayashida, Yuki Ohya, Hidekazu Yamamoto, Yutaka Sasaki, Yukihiro Inomata
AIM: The development of direct - acting oral agents has dramatically changed the treatment strategy of hepatitis C virus (HCV) infection. Here we aimed to reveal the efficacy and safety of daclatasvir (DCV) and asunaprevir (ASV) for recurrent HCV genotype 1 infection after liver transplantation (LT). METHODS: A retrospective study was conducted on 9 patients [5 men; 4 had failed peg-interferon/ribavirin, 2 had failed simeprevir/peg-interferon/ribavirin, 1 had the resistance-associated variant (RAV) Y93H in the NS5A region, 1 underwent maintenance dialysis ] who underwent a 24 -week DCV/ASV treatment regimen for recurrent HCV genotype 1 infection...
December 21, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27979266/anodic-stripping-voltammetry-with-gold-electrodes-as-an-alternative-method-for-the-routine-determination-of-mercury-in-fish-comparison-with-spectroscopic-approaches
#18
COMPARATIVE STUDY
Agnese Giacomino, Andrea Ruo Redda, Stefania Squadrone, Marco Rizzi, Maria Cesarina Abete, Carmela La Gioia, Rosanna Toniolo, Ornella Abollino, Mery Malandrino
The applicability to the determination of mercury in tuna of square wave anodic stripping voltammetry (SW-ASV) conducted at both solid gold electrode (SGE) and a gold nanoparticle-modified glassy carbon electrode (AuNPs-GCE) was demonstrated. Mercury content in two certified materials and in ten samples of canned tuna was measured. The performances of the electrodes were compared with one another as well as with two spectroscopic techniques, namely cold vapour atomic absorption spectroscopy (CV-AAS) and a direct mercury analyser (DMA)...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27940117/arsenic-enrichment-enhanced-root-exudates-and-altered-rhizosphere-microbial-communities-and-activities-in-hyperaccumulator-pteris-vittata
#19
Suvendu Das, Mon-Lin Chou, Jiin-Shuh Jean, Huai-Jen Yang, Pil Joo Kim
Phytoremediation of arsenic (As)-contaminated soil by hyperaccumulator Pteris vittata is promising. A better understanding of the rhizosphere microbial dynamics that regulate As availability and plant growth is important to optimize the phytoremediation process. In this study, Illumina sequencing of 16S rRNA genes was applied to assess the rhizosphere microbial community structure of P. vittata. Microbial functionality was monitored by soil enzyme activities and MPN-PCR targeting genes of interest. Arsenic (100mgkg(-1) AsV) addition to soil significantly increased DOC, root exudates, As and P uptake and the frond biomass of P...
March 5, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27914647/human-exposure-to-dietary-inorganic-arsenic-and-other-arsenic-species-state-of-knowledge-gaps-and-uncertainties
#20
Francesco Cubadda, Brian P Jackson, Kathryn L Cottingham, Yoshira Ornelas Van Horne, Margaret Kurzius-Spencer
Inorganic arsenic (iAs) is ubiquitous in the environment as arsenite (AsIII) and arsenate (AsV) compounds and biotransformation of these toxic chemicals leads to the extraordinary variety of organoarsenic species found in nature. Despite classification as a human carcinogen based on data from populations exposed through contaminated drinking water, only recently has a need for regulatory limits on iAs in food been recognized. The delay was due to the difficulty in risk assessment of dietary iAs, which critically relies on speciation analysis providing occurrence data for iAs in food - and not simply for total arsenic...
February 1, 2017: Science of the Total Environment
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