Tatiana V Kudryashova, Swati Dabral, Sreenath Nayakanti, Arnab Ray, Dmitry A Goncharov, Theodore Avolio, Yuanjun Shen, Analise Rode, Andressa Pena, Lifeng Jiang, Derek Lin, Jeffrey Baust, Timothy N Bachman, Johannes Graumann, Clemens Ruppert, Andreas Guenther, Mario Schmoranzer, Yann Grobs, Sarah Eve Lemay, Eve Tremblay, Sandra Breuils-Bonnet, Olivier Boucherat, Ana L Mora, Horace DeLisser, Jing Zhao, Yutong Zhao, Sébastien Bonnet, Werner Seeger, Soni S Pullamsetti, Elena A Goncharova
RATIONALE: The MSTs (mammalian Ste20-like kinases) 1/2 are members of the HIPPO pathway that act as growth suppressors in adult proliferative diseases. Pulmonary arterial hypertension (PAH) manifests by increased proliferation and survival of pulmonary vascular cells in small PAs, pulmonary vascular remodeling, and the rise of pulmonary arterial pressure. The role of MST1/2 in PAH is currently unknown. OBJECTIVE: To investigate the roles and mechanisms of the action of MST1 and MST2 in PAH...
March 4, 2022: Circulation Research