keyword
MENU ▼
Read by QxMD icon Read
search

Yi Zhong

keyword
https://www.readbyqxmd.com/read/27908611/entorhinal-principal-neurons-mediate-brain-stimulation-treatments-for-epilepsy
#1
Zhenghao Xu, Yi Wang, Bin Chen, Cenglin Xu, Xiaohua Wu, Ying Wang, Shihong Zhang, Weiwei Hu, Shuang Wang, Yi Guo, Xiangnan Zhang, Jianhong Luo, Shumin Duan, Zhong Chen
Brain stimulation is an alternative treatment for epilepsy. However, the neuronal circuits underlying its mechanisms remain obscure. We found that optogenetic activation (1Hz) of entorhinal calcium/calmodulin-dependent protein kinase II α (CaMKIIα)-positive neurons, but not GABAergic neurons, retarded hippocampal epileptogenesis and reduced hippocampal seizure severity, similar to that of entorhinal low-frequency electrical stimulation (LFES). Optogenetic inhibition of entorhinal CaMKIIα-positive neurons blocked the antiepileptic effect of LFES...
November 23, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27904764/mir-193b-directly-targets-stmn1-and-inhibits-the-malignant-phenotype-in-colorectal-cancer
#2
Feng Guo, Yang Luo, Yi-Fei Mu, Shao-Lan Qin, Yang Qi, Yi-Er Qiu, Ming Zhong
Accumulating evidence suggests that aberrantly expressed microRNAs (miRNAs) contribute to the initiation and progression of human cancers. However, the underlying function of miR-193b in colorectal cancer (CRC) remains largely unexplored. Herein, we demonstrate that miR-193b is significantly down-regulated in CRC tissues compared with their normal counterparts. Kaplan-Meier analysis revealed that decreased miR-193b expression was closely associated with the shorter overall survival of patients with CRC. Through gain-and loss-of-function studies, we showed that miR-193b significantly suppressed CRC cell proliferation and invasion...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27904161/professor-huang-sheng-kai
#3
Yi-Zhong Hu, Ling Gao
No abstract text is available yet for this article.
November 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27902325/targeting-naturally-occurring-epitope-variants-of-hepatitis-c-virus-with-high-affinity-t-cell-receptors
#4
Huajun Zhang, Jianbing Zhang, Lei Chen, Zhiming Weng, Ye Tian, Haifeng Zhao, Youjia Li, Lin Chen, Zhaoduan Liang, Hongjun Zheng, Wenzhuo Zhao, Shi Zhong, Yi Li
Hepatitis C virus (HCV) readily establishes chronic infection, which is characterized by failure of virus-specific CD8+ T cells. HCV uses epitope mutation and T-cell exhaustion to escape from the host immune response. Previously, we engineered high-affinity T-cell receptors (HATs) targeting HIV escape mutants. In this study, the affinity of a T-cell receptor specific for the human leukocyte antigen (HLA)-A2-restricted HCV immunodominant epitope NS3 1406-1415 (KLVALGINAV) was improved from a KD of 6.6 µM to 40 pM...
November 11, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27901005/characteristics-of-electroencephalogram-arousals-of-sleep-disordered-breathing-children-at-different-sleep-stages
#5
Da-Bo Liu, Yu-Jing Yao, Zhen-Yun Huang, Jian-Wen Zhong, Jia-Jian Xu, Shu-Yao Qiu, Shao-Feng Liu, Xin-Hua Yi
No abstract text is available yet for this article.
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27899943/effects-of-allitridum-on-the-transient-outward-potassium-current-in-rats-with-heart-failure
#6
Xiao-Jing Zhao, Kun Lin, Yu Zhang, Bin Xu, Li Liu, Yi-Cheng Fu, Xi Chen, Zhong-Qi Cai, Zhi-Juan Wu, Yun Huang, Yang Li
OBJECTIVE: To study the effect of allitridum on the transient outward potassium current (Ito) of ventricular myocytes in heart failure (HF). METHODS: The dual enzymatic method was used to separate single ventricular myocytes from Sprague Dawley rats. Patch-clamping was used to record Ito and analyze the effect of allitridum on the current. RESULTS: The Ito current had a significant decrease in the HF group, compared with the control group...
September 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27898307/a-ca-2-chelator-ameliorates-chromium-vi-induced-hepatocyte-l-02-injury-via-down-regulation-of-voltage-dependent-anion-channel-1-vdac1-expression
#7
Xing Yi, Fang Xiao, Xiali Zhong, Yujie Duan, Kaihua Liu, Caigao Zhong
Hexavalent chromium could result in cell malfunctions. Intracellular Ca(2+) ([Ca(2+)]i) content and VDAC1 expression are both important features related to cell survial. This study aimed to explore the mechanism of cell injury induced by Cr(VI) and tentatively offer clues to repairing this cell damage using [Ca(2+)]i and VDAC1. L-02 hepatocytes were treated with Cr(VI)/BAPTA, and the levels of [Ca(2+)]i and cell injury associated with Cr(VI) were determined in addition to the effect of BAPTA. The expression of VDAC1 in Cr(VI)-induced cells was evaluated...
November 18, 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27896428/xci-escaping-gene-kdm5c-contributes-to-ovarian-development-via-downregulating-mir-320a
#8
Yi-Xi Sun, Yi-Xin Zhang, Dan Zhang, Chen-Ming Xu, Song-Chang Chen, Jun-Yu Zhang, Ye-Chun Ruan, Feng Chen, Run-Ju Zhang, Ye-Qing Qian, Yi-Feng Liu, Lu-Yang Jin, Tian-Tian Yu, Hai-Yan Xu, Yu-Qin Luo, Xin-Mei Liu, Fei Sun, Jian-Zhong Sheng, He-Feng Huang
Mechanisms underlying female gonadal dysgenesis remain unclarified and relatively unstudied. Whether X-chromosome inactivation (XCI)-escaping genes and microRNAs (miRNAs) contribute to this condition is currently unknown. We compared 45,X Turner Syndrome women with 46,XX normal women, and investigated differentially expressed miRNAs in Turner Syndrome through plasma miRNA sequencing. We found that miR-320a was consistently upregulated not only in 45,X plasma and peripheral blood mononuclear cells (PBMCs), but also in 45,X fetal gonadal tissues...
November 28, 2016: Human Genetics
https://www.readbyqxmd.com/read/27892922/convergence-and-divergence-of-bitterness-biosynthesis-and-regulation-in-cucurbitaceae
#9
Yuan Zhou, Yongshuo Ma, Jianguo Zeng, Lixin Duan, Xiaofeng Xue, Huaisong Wang, Tao Lin, Zhiqiang Liu, Kewu Zeng, Yang Zhong, Shu Zhang, Qun Hu, Min Liu, Huimin Zhang, James Reed, Tessa Moses, Xinyan Liu, Peng Huang, Zhixing Qing, Xiubin Liu, Pengfei Tu, Hanhui Kuang, Zhonghua Zhang, Anne Osbourn, Dae-Kyun Ro, Yi Shang, Sanwen Huang
Differentiation of secondary metabolite profiles in closely related plant species provides clues for unravelling biosynthetic pathways and regulatory circuits, an area that is still underinvestigated. Cucurbitacins, a group of bitter and highly oxygenated tetracyclic triterpenes, are mainly produced by the plant family Cucurbitaceae. These compounds have similar structures, but differ in their antitumour activities and ecophysiological roles. By comparative analyses of the genomes of cucumber, melon and watermelon, we uncovered conserved syntenic loci encoding metabolic genes for distinct cucurbitacins...
November 28, 2016: Nature Plants
https://www.readbyqxmd.com/read/27889863/genetic-association-study-between-rit2-and-parkinson-s-disease-in-a-han-chinese-population
#10
Jun-Ying Li, Jin-Hong Zhang, Nan-Nan Li, Ling Wang, Zhong-Jiao Lu, Lan Cheng, Xiao-Yi Sun, Rong Peng
Recent several meta-analyses and certain case-control studies suggested that the Ras-like without CAAX 2 (RIT2) rs12456492 increased the risk of Parkinson's disease (PD) in Asian and Caucasian populations. However, as so far, the association between RIT2 rs12456492 and PD is still controversial. We investigated genetic association of RIT2 rs12456492 with PD susceptibility in a Han Chinese population of 1747 ethnic Han Chinese subjects comprising 884 PD patients and 863 healthy controls. The minor allele frequency (MAF) of G at the RIT2 rs12456492 was not significantly different between the cases and the controls...
November 26, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27888625/trim11-a-direct-target-of-mir-24-3p-promotes-cell-proliferation-and-inhibits-apoptosis-in-colon-cancer
#11
Yan Yin, Jun Zhong, Si-Wei Li, Jian-Zhe Li, Min Zhou, Yin Chen, Yi Sang, Lijuan Liu
TRIM11 (tripartite motif-containing protein 11) is an E3 ubiquitin ligase recently identified as an oncogene in malignant glioma and lung cancer. In the present study, we report that expression of TRIM11 was increased in colon cancer (CC) tissue relative to paired normal tissues and that higher TRIM11 levels predicted poor overall survival (OS) and disease-free survival (DFS) in CC patients. Mechanistically, we showed that miR-24-3p downregulation contributes to TRIM11 upregulation in CC. We also demonstrated that TRIM11 overexpression promotes cell proliferation and colony formation and inhibits apoptosis in CC, while knocking down TRIM11 using CRISPR/Cas9-mediated genome editing inhibited cell proliferation and induced apoptosis...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27886141/comprehensive-transcriptome-analysis-provides-evidence-of-local-thermal-adaptation-in-three-loaches-genus-misgurnus
#12
Shaokui Yi, Sai Wang, Jia Zhong, Weimin Wang
The geographic distribution of three Misgurnus species, M. anguillicaudatus, M. bipartitus, and M. mohoity, displays a specific pattern in China, coincident with temperature zones. In this study, we sequenced the transcriptomes of these three species and used the sequences to investigate the lineage-specific adaptations within the genus Misgurnus. In total, 51 orphan genes (19 in M. anguillicaudatus, 18 in M. bipartitus, and 14 in M. mohoity) that may contribute to the species-specific adaptations were identified...
November 24, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27884749/celecoxib-exerts-antitumor-effects-in-hl-60-acute-leukemia-cells-and-inhibits-autophagy-by-affecting-lysosome-function
#13
Ying Lu, Xiang-Fu Liu, Ting-Rong Liu, Rui-Fang Fan, Yi-Chuan Xu, Xiang-Zhong Zhang, Ling-Ling Liu
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, has been demonstrated to exert antitumor activity in a variety of cancer cells. The underlying mechanism involves inhibition of cell cycle progression and induction of apoptosis. Besides, celecoxib has also been found to induce autophagy in some solid tumor cells. The aim of this study was to investigate the effect of celecoxib on cell proliferation in HL-60 human acute leukemia cells and to explore the potential mechanism. HL-60 cells were exposed to various concentrations of celecoxib and cell viability was evaluated by the MTT assay...
November 21, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27882943/metadherin-facilitates-podocyte-apoptosis-in-diabetic-nephropathy
#14
Wen-Ting Liu, Fen-Fen Peng, Hong-Yu Li, Xiao-Wen Chen, Wang-Qiu Gong, Wen-Jing Chen, Yi-Hua Chen, Pei-Lin Li, Shu-Ting Li, Zhao-Zhong Xu, Hai-Bo Long
Apoptosis, one of the major causes of podocyte loss, has been reported to have a vital role in diabetic nephropathy (DN) pathogenesis, and understanding the mechanisms underlying the regulation of podocyte apoptosis is crucial. Metadherin (MTDH) is an important oncogene, which is overexpressed in most cancers and responsible for apoptosis, metastasis, and poor patient survival. Here we show that the expression levels of Mtdh and phosphorylated p38 mitogen-activated protein kinase (MAPK) are significantly increased, whereas those of the microRNA-30 family members (miR-30s) are considerably reduced in the glomeruli of DN rat model and in high glucose (HG)-induced conditionally immortalized mouse podocytes (MPC5)...
November 24, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27882376/plasma-levels-of-the-anti-coagulation-protein-c-and-the-risk-of-ischaemic-heart-disease-a-mendelian-randomisation-study
#15
C Mary Schooling, Yi Zhong
Protein C is an environmentally modifiable anticoagulant, which protects against venous thrombosis, whether it also protects against ischaemic heart disease is unclear, based on observational studies and relatively small genetic studies. It was our study aim to clarify the role of protein C in ischaemic heart disease the risk of coronary artery disease/myocardial infarction (CAD/MI) was assessed according to genetically predicted protein C in very large studies. Associations with lipids and diabetes were similarly assessed to rule out effects via traditional cardiovascular disease risk factors...
November 24, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27882221/overexpression-of-suppressor-of-ikbke-1-is-associated-with-vincristine-resistance-in-colon-cancer-cells
#16
Chun-Peng Zhao, Zhong-Jie Xu, Qing Guo, Yun-Xiao Li, Xiang-Zheng Gao, Yi-You Peng
In a previous study, the suppressor of IKBKE 1 expression level was confirmed to be higher in vincristine (VCR)-resistant HCT-8 (HCT-8/V) colon cancer cells than in non-VCR-resistant HCT-8 cells. In the current study, IKBKE 1 expression in VCR-resistant colon cancer cells was investigated further. HCT-8 and HCT-8/V human colon cancer cells were used, and polymerase chain reaction (PCR) primers were designed to amplify the IKBKE 1 gene. Fluorescence reverse transcription-quantitative PCR (RT-qPCR) was performed to detect differences in IKBKE 1 expression between sensitive and drug-resistant colon cancer cell lines...
November 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27882172/downregulated-mir-486-5p-acts-as-a-tumor-suppressor-in-esophageal-squamous-cell-carcinoma
#17
Yunfeng Yi, Xiujuan Lu, Jianming Chen, Changjie Jiao, Jing Zhong, Zhiming Song, Xiaoping Yu, Baoli Lin
microRNAs (miRNAs/miRs) are crucial regulators of gene expression at the post-translational level through promoting mRNA degradation or the repression of translation of target genes. miRs have been confirmed to serve a dominant role in tumor biology. miR-486-5p has been ascertained to be involved in non-small-cell lung cancer, breast cancer and hepatocellular carcinoma; however, the expression and function of miR-486-5p in esophageal squamous cell carcinoma (ESCC) has yet to be elucidated. The present study aimed to analyze the expression levels of miR-486-5p in ESCC tissues and paired normal adjacent tissues, and determine the effects of miR-486-5p on esophageal cancer cells using MTT, wound scratch and apoptosis assays...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27881643/inclusion-body-fusion-of-human-parainfluenza-virus-type-3-regulated-by-acetylated-%C3%AE-tubulin-enhances-viral-replication
#18
Shengwei Zhang, Yanliang Jiang, Qi Cheng, Zhong Yi, Yali Qin, Mingzhou Chen
: Viral inclusion bodies (IBs) or replication factories are unique structures generated by viral proteins together with some cellular proteins as a platform for efficient viral replication, but little is known about the mechanism underlying IB formation and fusion. Our previous study demonstrated that the interaction between the nucleoprotein (N) and phosphoprotein (P) of human parainfluenza virus type 3 (HPIV3), an enveloped virus of great medical impact, can form IBs. In this study, we found that small IBs can fuse with each other to form large IBs that enhance viral replication...
November 23, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27881337/-inhibitory-effect-of-mig-7-silencing-by-retrovirus-mediated-shrna-on-vasculogenic-mimicry-invasion-and-metastasis-of-human-hepatocellular-carcinoma-cells-in-vitro
#19
Bo Qu, Guan-Nan Sheng, Fei Yu, Guan-Nan Chen, Qi Lv, Zhong-Peng Mao, Long Guo, Yi Lv
OBJECTIVE: To explore the inhibitory effect of migration-inducing gene 7 (Mig-7) gene silencing induced by retroviral-mediated small hairpin RNA (shRNA) on vasculogenic mimicry (VM), invasion and metastasis of human hepatocellular carcinoma (HCC) cells in vitro. METHODS: Two target sequences (Mig-7 shRNA-1 and Mig-7 shRNA-2) and one negative control sequence (Mig-7 shRNA-N) were synthesized. The recombinant retroviral vectors carrying Mig-7 shRNA were constructed, and HCC cell line MHCC-97H were transfected with Mig-7 shRNA-1, Mig-7 shRNA-2, Mig-7 shRNA-N, or the empty vector, or treated with 125 µg/mL recombinant human endostatin (ES)...
November 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27879388/an-ethylene-induced-regulatory-module-delays-flower-senescence-by-regulating-cytokinin-content
#20
Lin Wu, Nan Ma, Yangchao Jia, Yi Zhang, Ming Feng, Cai-Zhong Jiang, Chao Ma, Junping Gao
In many plant species, including rose (Rosa hybrida), flower senescence is promoted by the gaseous hormone, ethylene, and inhibited by cytokinin (CTK) class of hormones. However, the molecular mechanisms underlying these antagonistic effects are not well understood. In this current study, we characterized the association between a pathogenesis related PR-10 family gene from rose (RhPR10.1) and the hormonal regulation of flower senescence. Quantitative RT-PCR analysis showed that the RhPR10.1 was expressed at high levels during senescence in different floral organs, including petal, sepal, receptacle, stamen, and pistil, and that expression was induced by ethylene treatment...
November 22, 2016: Plant Physiology
keyword
keyword
106584
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"