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Linx procedure

Emanuele Asti, Gianluca Bonitta, Andrea Lovece, Veronica Lazzari, Luigi Bonavina
Only a minority of patients with gastro-esophageal reflux disease (GERD) are offered a surgical option. This is mostly due to the fear of potential side effects, the variable success rate, and the extreme alteration of gastric anatomy with the current gold standard, the laparoscopic Nissen fundoplication. It has been reported that laparoscopic Toupet fundoplication (LTF) and laparoscopic sphincter augmentation using a magnetic device (LINX) can treat reflux more physiologically and with a lower incidence of side-effects and reoperation rate...
July 2016: Medicine (Baltimore)
Narin Sriratanaviriyakul, Celeste Kivler, Tamas J Vidovszky, Ken Y Yoneda, Nicholas J Kenyon, Susan Murin, Samuel Louie
BACKGROUND: Gastroesophageal reflux disease is one of the most common comorbidities in patients with asthma. Gastroesophageal reflux disease can be linked to difficult-to-control asthma. Current management includes gastric acid suppression therapy and surgical antireflux procedures. The LINX® procedure is a novel surgical treatment for patients with gastroesophageal reflux disease refractory to medical therapy. To the best of our knowledge, we report the first case of successful treatment of refractory asthma secondary to gastroesophageal reflux disease using the LINX® procedure...
2016: Journal of Medical Case Reports
Emanuele Asti, Stefano Siboni, Veronica Lazzari, Gianluca Bonitta, Andrea Sironi, Luigi Bonavina
OBJECTIVE: The aim of this study was to identify patients' characteristics that may predict failure and removal of the Linx sphincter augmentation device, and to report the results of 1-stage laparoscopic removal and fundoplication. BACKGROUND: The Linx device is a long-term magnetic implant that was developed as a less disruptive and more reproducible surgical option for patients with early-stage gastroesophageal reflux disease (GERD). Removal of the device has been shown to be feasible, but no long-term results of this procedure have been reported yet...
May 9, 2016: Annals of Surgery
Kenneth Desart, Georgios Rossidis, Michael Michel, Tamara Lux, Kfir Ben-David
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has gained significant popularity in the USA, and consequently resulted in patients experiencing new-onset gastroesophageal reflux disease (GERD) following this bariatric procedure. Patients with GERD refractory to medical therapy present a more challenging situation limiting the surgical options to further treat the de novo GERD symptoms since the gastric fundus to perform a fundoplication is no longer an option. OBJECTIVES: The aim of this study is to determine if the LINX® magnetic sphincter augmentation system is a safe and effective option for patients with new gastroesophageal reflux disease following laparoscopic sleeve gastrectomy...
October 2015: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Eric G Sheu, David W Rattner
PURPOSE OF REVIEW: To evaluate the current data on the safety, efficacy, and indications for magnetic sphincter augmentation (MSA) using the LINX device to treat gastroesophageal reflux disease (GERD). RECENT FINDINGS: The LINX device has demonstrated excellent safety and GERD efficacy in several recent nonblinded, single arm studies with strict inclusion criteria and up to 3 years follow-up. Dysphagia has been the most common adverse effect occurring after LINX...
July 2015: Current Opinion in Gastroenterology
Margit Bauer, Alexander Meining, Michael Kranzfelder, Alissa Jell, Rebekka Schirren, Dirk Wilhelm, Helmut Friess, Hubertus Feussner
BACKGROUND: The history of surgical antireflux treatment is coined by the search for better alternatives to Nissen fundoplication. Implantable devices are one option, beginning with the "Angelchik" prosthesis 30 years ago. However, this procedure was left soon because of the high rate of foreign body connected problems (migration, perforation). A modern approach is a magnetic sphincter augmentation device (LINX Reflux Management System, Torax Medical, Shoreview, MN, USA), a magnetic chain which is implanted laparoscopically...
December 2015: Surgical Endoscopy
O O Koch, G Köhler, H Wundsam, M Weitzendorfer, G O Spaun, K Emmanuel
For patients with gastroesophageal reflux disease (GERD) who suffer from severe symptoms despite adequate medical therapy, interventional procedures are the only option for improving symptoms and thus the quality of life. In the clinical practice it is decisive if a hiatal hernia (HH) is present or not and whether it is larger or smaller than 2-3 cm. Patients who have a HH > 2-3 cm should undergo laparoscopic fundoplication with hiatal hernia repair. Patients with a larger HH are no longer eligible for endoscopic therapy as closure of the HH is not endoscopically possible...
October 2015: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Steven R DeMeester
Gastroesophageal reflux disease is a common disorder in the United States and other western countries. In addition to troublesome symptoms, this condition is associated with impaired quality of life and the potential for disease progression to esophageal adenocarcinoma. Acid suppression medications are extremely effective for the relief of heartburn symptoms, but don't address the physiologic derangements that cause reflux. The goal of an antireflux procedure is to correct these defects and abolish the dietary and lifestyle compromises that accompany medical therapy for gastroesophageal reflux...
March 2015: Current Treatment Options in Gastroenterology
Carla Maradey-Romero, Hemangi Kale, Ronnie Fass
There has been a marked decline over the last several years in drug development for gastroesophageal reflux disease and specifically for nonerosive reflux disease (NERD), despite there being many areas of unmet need. In contrast, we have seen a proliferation, during the same period of time, in development of novel, nonmedical therapeutic strategies for NERD using cutting-edge technology. Presently, compliance and lifestyle modifications are readily available noninvasive therapeutic interventions for NERD. Other nonmedical therapies include, the Stretta procedure, transoral incisionless fundoplication, and the magnetic sphincter augmentation device (LINX)...
August 2014: Journal of Clinical Gastroenterology
Katrin Schwameis, Michael Schwameis, Barbara Zörner, Johannes Lenglinger, Reza Asari, Franz Martin Riegler, Sebastian Friedrich Schoppmann
BACKGROUND: Gastroesophageal reflux disease (GERD) is a common chronic disease requiring adequate treatment since it represents one major cause of development of Barrett's esophagus and eventually carcinoma. Novel laparoscopic magnetic sphincter augmentation for GERD was evaluated prospectively. PATIENTS AND METHODS: A total of 23 patients with GERD underwent minimally invasive implantation of LINX™ Reflux Management System. Primary outcome measures were overall feasibility, short-term procedure safety and efficacy...
May 2014: Anticancer Research
Luigi Bonavina, Stefano Siboni, Greta I Saino, Demetrio Cavadas, Italo Braghetto, Attila Csendes, Owen Korn, Edgar J Figueredo, Lee L Swanstrom, Eelco Wassenaar
This paper includes commentaries on outcomes of esophageal surgery, including the mechanisms by which fundoduplication improves lower esophageal sphincter (LES) pressure; the efficacy of the Linx™ management system in improving LES function; the utility of radiologic characterization of antireflux valves following surgery; the correlation between endoscopic findings and reported symptoms following antireflux surgery; the links between laparoscopic sleeve gastrectomy and decreased LES pressure, endoscopic esophagitis, and gastroesophageal reflux disease (GERD); the less favorable outcomes following fundoduplication among obese patients; the application of bioprosthetic meshes to reinforce hiatal repair and decrease the incidence of paraesophageal hernia; the efficacy of endoluminal antireflux procedures, and the limited efficacy of revisional antireflux operations, underscoring the importance of good primary surgery and diligent work-up to prevent the necessity of revisional procedures...
October 2013: Annals of the New York Academy of Sciences
Luigi Bonavina, Greta Saino, John C Lipham, Tom R Demeester
Gastroesophageal reflux disease (GERD) results from incompetency of the lower esophageal sphincter that allows the contents of the stomach to reflux into the esophagus, the airways, and the mouth. The disease affects about 10% of the western population and has a profound negative impact on quality of life. The majority of patients are successfully treated with proton-pump inhibitors, but up to 40% have incomplete relief of symptoms even after dose adjustment. The laparoscopic Nissen fundoplication represents the surgical gold standard, but is largely underused because of the level of technical difficulty and the prevalence of side effects...
July 2013: Therapeutic Advances in Gastroenterology
Luigi Bonavina, Tom R DeMeester, Robert A Ganz
Gastroesophageal reflux disease (GERD), commonly manifested by heartburn or regurgitation, is a chronic, progressive condition in which failed sphincter function allows the contents of the stomach to reflux into the esophagus, the airways and the mouth. Chronic GERD affects 10% of Western society. The majority of patients receive adequate relief from proton pump inhibitors, but up to 40% have incomplete relief of symptoms that cannot be addressed by increasing the dose of medications. The laparoscopic Nissen fundoplication is the surgical gold standard; however, the level of technical difficulty and its side effects have limited its use to less than 1% of the GERD population...
December 2012: Expert Review of Gastroenterology & Hepatology
Zhi-gang Li
Gastroesophageal reflux disease (GERD) is the most common gastrointestinal diagnosis recorded during visits to outpatient clinics in west countries. The prevalence of symptom-defined GERD in China is as high as 3% to 5%. Asa dysfunction, GERD is characterized by reflux and heartburns. The pathophysiologic process of GERD is very complicated and subtle. The spectrum of injury from long-term reflux of acid or bile includes damage mucosa, Barrett's esophagus, dysplasia, and esophageal cancer. Therefore, the therapies of GERD should focus on controlling symptom,treating complications, and surveillance the possibility of oncologic transform...
September 2012: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
John C Lipham, Tom R DeMeester, Robert A Ganz, Luigi Bonavina, Greta Saino, Daniel H Dunn, Paul Fockens, Willem Bemelman
BACKGROUND: Sphincter augmentation with the LINX® Reflux Management System is a surgical option for patients with chronic gastroesophageal disease (GERD) and an inadequate response to proton pump inhibitors (PPIs). Clinical experience with sphincter augmentation is now available out to 4 years. METHODS: In a multicenter, prospective, single-arm study, 44 patients underwent a laparoscopic surgical procedure for placement of the LINX System around the gastroesophageal junction (GEJ)...
October 2012: Surgical Endoscopy
C Daniel Smith
This article covers some new areas of development in esophageal surgery. Specific topics include reviews of long-term outcomes after laparoscopic antireflux surgery, the use of surgically placed implantable device for LES augmentation (Linx), the use of mesh for hiatal hernioplasty, and prone and nonthoracic approaches to minimally invasive esophagectomy.
January 2010: Gastrointestinal Endoscopy Clinics of North America
Sven Lehmann, Thomas Walther, Sergey Leontjev, Jörg Kempfert, Ardawan Rastan, Jens Garbade, Michael A Borger, Volkmar Falk, Friedrich W Mohr
BACKGROUND AND AIM OF THE STUDY: The study aim was to evaluate the mid-term results after implantation of the stented porcine xenograft (Epic valve with Linx anticalcification treatment) in elderly patients. METHODS: A total of 1,368 patients undergoing aortic valve replacement (AVR; n = 1,168), mitral valve replacement (MVR; n = 101) or double valve replacement (DVR; n = 105) between November 2001 and November 2006, was evaluated. The indication for Epic implantation was patient age > or = 70 years, with pathology not amenable to valve repair...
November 2007: Journal of Heart Valve Disease
Giuseppe Milano, Pier Damiano Mulas, Fabio Ziranu, Stefano Piras, Andrea Manunta, Carlo Fabbriciani
PURPOSE: The aim of the present study was to compare the mechanical behavior of some devices used for femoral fixation of doubled hamstring tendon graft in anterior cruciate ligament (ACL) reconstruction when included in a graft fixation complex (GFC). METHODS: An ACL reconstruction was performed on 90 porcine knees. The graft used was the doubled lateral extensor of toes (DLET). Nine different femoral fixation devices were tested and classified according to their fixation mechanism: compression (Bioscrew and RCI screw); expansion (Rigidfix); cortical suspension (Ligament Anchor, EndoButton-CL, and Swing Bridge); cancellous suspension (Linx-HT); and cortical-cancellous suspension (Transfix and Bio-Transfix)...
June 2006: Arthroscopy: the Journal of Arthroscopic & related Surgery
Carlo Fabbriciani, Pier Damiano Mulas, Fabio Ziranu, Laura Deriu, Donatella Zarelli, Giuseppe Milano
This study evaluates the structural properties of the femur-anterior cruciate ligament (ACL) graft-tibia complex, comparing different graft fixation techniques in sheep knees. Four fixation devices were tested both for femoral fixation (Transfix, absorbable screw, RCI screw and Linx-HT) and tibial fixation (bone plug with metal screw, absorbable screw with staple, RCI screw and cancellous screw with spiked washer). The graft used for ACL reconstruction was fresh ovine doubled Achilles tendon (DAT). Femurs and tibias were tested separately...
April 2005: Knee
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