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Bronchial thermoplasty

D C Watchorn, A Sahadevan, J J Egan, S J Lane
There is an unmet need for new therapies in severe persistent asthma. Bronchial thermoplasty is a bronchoscopic procedure which employs radiofrequency energy to reduce airway smooth muscle and has been demonstrated to improve symptomatic control in severe persistent asthma in other populations. Seven patients have completed bronchial thermoplasty at a tertiary referral centre in Ireland. Asthma Control Test scores and data on hospitalisations, exacerbations, maintenance corticosteroid requirements, rescue bronchodilator use and peak expiratory flow rate (PEFR) were compared one year before and one year post treatment...
2016: Irish Medical Journal
Rita Arrigo, Giuseppe Failla, Nicola Scichilone, Alba La Sala, Carla Galeone, Salvatore Battaglia, Alida Benfante, Nicola Facciolongo
There is limited information on the efficacy and safety of bronchial thermoplasty (BT) in real life. We evaluated the outcomes of the randomized clinical trials for BT in severe asthmatics, in whom the exclusion criteria were not strictly controlled. A case series of seven asthmatics (M/F: 4/3; age: 54.6 ± 2.9 years) is reported. Subjects had a statistically significant improvement in AQLQ (from a mean of 3.96 ± 1.1 to 4.5 ± 1.2 and 5.5 ± 0.6 after 6 and 12 months of treatment; p = 0.0007) and in the ACQ score (from 2...
2016: BioMed Research International
Francesco Menzella, Mirco Lusuardi, Carla Galeone, Nicola Facciolongo, Luigi Zucchi
Despite several therapeutic choices, 10-20% of patients with severe uncontrolled asthma do not respond to maximal best standard treatments, leading to a healthcare expenditure of up to 80% of overall costs for asthma. Today, there are new important therapeutic strategies, both pharmacological and interventional, that can result in improvement of severe asthma management, such as omalizumab, bronchial thermoplasty and other biological drugs, for example, mepolizumab, reslizumab and benralizumab. The availability of these new treatments and the increasing knowledge of the different asthmatic phenotypes and endotypes makes correct patient selection increasingly complex and important...
September 9, 2016: Therapeutic Advances in Respiratory Disease
Marina Pretolani, Anders Bergqvist, Gabriel Thabut, Marie-Christine Dombret, Dominique Knapp, Fatima Hamidi, Loubna Alavoine, Camille Taillé, Pascal Chanez, Jonas S Erjefält, Michel Aubier
BACKGROUND: The effectiveness of bronchial thermoplasty (BT) has been reported in severe asthma, yet its impact on the different bronchial structures remains unknown. OBJECTIVE: To examine the effect of BT on bronchial structures and to explore their association with clinical outcome in severe refractory asthmatics. METHODS: Bronchial biopsies (n = 300) were collected from 15 severe uncontrolled asthmatics before and 3 months after BT. Immunostained sections were assessed for airway smooth muscle (ASM) area, sub-epithelial basement membrane thickness, nerve fibers and epithelium neuroendocrine cells...
September 5, 2016: Journal of Allergy and Clinical Immunology
Ikhlass Haj Salem, Louis-Philippe Boulet, Sabrina Biardel, Noel Lampron, Simon Martel, Michel Laviolette, Jamila Chakir
No abstract text is available yet for this article.
August 2016: Annals of the American Thoracic Society
Abhaya Trivedi, Ian D Pavord, Mario Castro
Although a small proportion of patients with asthma have severe disease, it accounts for the majority of morbidity related to the illness. Severe asthma comprises a heterogeneous group of phenotypes. Targeted treatments for these phenotypes represent a major advancement in the management of severe asthma. Omalizumab, a monoclonal antibody to IgE, improves asthma control in patients with a predominant allergic phenotype. Monoclonal antibodies targeted to interleukin 4α and interleukin 5 have shown substantial benefit in patients with the eosinophilic asthma phenotype; so too have monoclonal antibodies targeted to interleukin 13 in patients with a type 2 allergic phenotype...
July 2016: Lancet Respiratory Medicine
Narin Sriratanaviriyakul, Celeste Kivler, Tamas J Vidovszky, Ken Y Yoneda, Nicholas J Kenyon, Susan Murin, Samuel Louie
BACKGROUND: Gastroesophageal reflux disease is one of the most common comorbidities in patients with asthma. Gastroesophageal reflux disease can be linked to difficult-to-control asthma. Current management includes gastric acid suppression therapy and surgical antireflux procedures. The LINX® procedure is a novel surgical treatment for patients with gastroesophageal reflux disease refractory to medical therapy. To the best of our knowledge, we report the first case of successful treatment of refractory asthma secondary to gastroesophageal reflux disease using the LINX® procedure...
2016: Journal of Medical Case Reports
Wen Wang, Jiang-tao Lin, Nan Su, Ying Nong, Hong Hong, Yi-qing Yin, Cheng-hui Li
OBJECTIVE: To compare the effectiveness of high-frequency jet ventilation via Wei jet nasal airway and controlled ventilation with improved laryngeal mask airway during bronchial thermoplasty. METHODS: Twenty-eight patients undergoing bronchial thermoplasty were equally divided into two groups: group A (high-frequency jet ventilation through Wei jet nasal airway) and group B (controlled ventilation with improved laryngeal mask airway). Pulse oxygenation,heart rate,and mean arterial blood pressure were recorded after entering the operating room (T0), 1 minute after administration/induction (T1), bronchoscope inserting (T2), 15 minutes (T3)/30 minutes (T4)/45 minutes (T5) after ventilation,at the end of the operation (T6), and at the recovery of patients' consciousness (T7)...
April 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
Adalberto Rubin, Suzana Zelmanovitz, Manuela Cavalcanti, Fernanda Spilimbergo, Paulo Goldenfum, José Felicetti, Paulo Cardoso
No abstract text is available yet for this article.
April 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Dan-Vinh Nguyen, Susan Murin
Bronchial thermoplasty has been found to be a safe and effective therapy for severe asthma. We report the case of a mediastinal hematoma and hemothorax developing in a 66-year-old woman several days after an uneventful bronchial thermoplasty of the right lower lobe. Evaluation revealed a bleeding right bronchial artery pseudoaneurysm. Pseudoaneuryms have been reported in association with other procedures involving the therapeutic application of thermal energy, and a single case of hemoptysis requiring bronchial artery embolization occurred in a clinical trial of bronchial thermoplasty...
April 2016: Chest
Balaji Laxmanan, Katarine Egressy, Septimiu D Murgu, Steven R White, D Kyle Hogarth
Bronchial thermoplasty (BT) is a therapeutic intervention that delivers targeted thermal energy to the airway walls with the goal of ablating the smooth muscle in patients with severe persistent asthma. Since the publication of the original preclinical studies, three large randomized clinical trials evaluating its impact on asthma control have been performed. These trials have shown improvements in asthma-related quality of life and a reduction in asthma exacerbations following treatment with BT. However, there remains significant controversy regarding the true efficacy of BT and the interpretation of these studies, particularly the Asthma Intervention Research 2 trial...
September 2016: Chest
Ruofan Qiu, Jiangtao Lin
No abstract text is available yet for this article.
March 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
Qingling Zhang, Xiaoxian Zhang, Jiaxing Xie, Rihuang Qiu, Yu Chen, Zhiyong Huang, Ying He, Mo Xian, Jing Li, Shiyue Li
OBJECTIVE: To assess the effectiveness and safety of bronchial thermoplasty (BT) in the treatment of severe asthma. METHODS: The safety and effectiveness of BT were studied prospectively in 6 patients with poorly controlled severe asthma on long-term inhaled high-dose glucocorticoids and long-acting beta2-agonists in the First Affiliated Hospital of Guangzhou Medical University. Outcomes assessed after BT included asthma symptoms, frequency of acute exacerbations, pulmonary function, medication adjustment, and postoperative complications at 6 and 12 months after treatment...
March 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
Ying Nong, Nan Su, Jiangtao Lin, Xin Chen, Qing Zhao, Chunyan Han, Yongming Zhang, Xiaoyan Zhang, Zhencui Ren, Xiaopan Li
OBJECTIVE: To assess the effectiveness and safety of bronchial thermoplasty (BT) in patients with severe asthma. METHOD: The China-Japan Friendship Hospital recruited 12 patients with severe asthma who were voluntary to take BT treatment from March 2014 to November 2014. The levels of airway inflammation and biological markers (percentage of blood eosinophils, percentage of sputum eosinophils, serum IgE, fractional exhaled nitric oxide) of the patients were examined before the treatment in order to identify the types of airway inflammation...
March 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
Shiyue Li
No abstract text is available yet for this article.
March 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
Jiangtao Lin, Ruofan Qiu
No abstract text is available yet for this article.
March 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
Dorothy M Ryan, Stephen J Fowler, Robert M Niven
No abstract text is available yet for this article.
July 2016: Journal of Allergy and Clinical Immunology
Jian Ping Zhou, Qing Yun Li
No abstract text is available yet for this article.
June 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Chelle Pope Wilhelm, Bradley E Chipps
No abstract text is available yet for this article.
February 2016: Annals of Allergy, Asthma & Immunology
Reynold A Panettieri
No abstract text is available yet for this article.
November 2015: Annals of the American Thoracic Society
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