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https://www.readbyqxmd.com/read/28931097/-approaching-new-pharmacotherapy-options-in-pain-treatment
#1
András Telekes
The evolution of medicine is noticeable in most therapeutic areas, the worse the current therapeutic result, the more quick the improvement. This is especially true in such areas that require substantial social resources, namely oncology, diabetology and CNS diseases. Pain is not a disease, it is a symptom. Pain is one of the most important components of human suffering thus it deserves special attention. In recent years new formulations of old medicines were introduced rather than new medicines. Maybe ziconitide is the last pain killer with new mechanism of action which was approved by FDA in 2004...
September 20, 2017: Magyar Onkologia
https://www.readbyqxmd.com/read/28931066/finite-time-synchronization-of-memristor-based-cohen-grossberg-neural-networks-with-mixed-delays
#2
Chuan Chen, Lixiang Li, Haipeng Peng, Yixian Yang
Finite time synchronization, which means synchronization can be achieved in a settling time, is desirable in some practical applications. However, most of the published results on finite time synchronization don't include delays or only include discrete delays. In view of the fact that distributed delays inevitably exist in neural networks, this paper aims to investigate the finite time synchronization of memristor-based Cohen-Grossberg neural networks (MCGNNs) with both discrete delay and distributed delay (mixed delays)...
2017: PloS One
https://www.readbyqxmd.com/read/28930984/high-fat-diet-feeding-and-high-throughput-triacylglyceride-assay-in-drosophila-melanogaster
#3
Soda Balla Diop, Ryan T Birse, Rolf Bodmer
Heart disease is the number one cause of human death worldwide. Numerous studies have shown strong connections between obesity and cardiac malfunction in humans, but more tools and research efforts are needed to better elucidate the mechanisms involved. For over a century, the genetically highly tractable model of Drosophila has been instrumental in the discovery of key genes and molecular pathways that proved to be highly conserved across species. Many biological processes and disease mechanisms are functionally conserved in the fly, such as development (e...
September 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28929939/the-development-of-the-professional-values-model-in-nursing
#4
Ayla Kaya, İlkay Boz
One of the most important criteria for professionalism is accumulation of knowledge that is usable in professional practice. Nursing models and theories are important elements of accumulating nursing knowledge and have a chance to guarantee the ethical professional practice. In recent years, there has been an increase in the use of models in nursing research and newly created terminology has started to be used in nursing. In this study, a new model, termed as the Professional Values Model, developed by the authors was described...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28929430/new-drugs-in-the-pipeline-for-the-treatment-of-hiv-a-review
#5
REVIEW
Leigh Anne Hylton Gravatt, Crystal R Leibrand, Sulay Patel, MaryPeace McRae
PURPOSE OF REVIEW: The purpose of this paper is to review therapies with new mechanisms of action for the treatment of HIV that are at least in phase 2 clinical trials. RECENT FINDINGS: There are several new mechanisms of action being represented within clinical development, including histone deacetylase (HDAC) inhibitors, gene therapies, broadly neutralizing anti-HIV antibodies, immune modulation, and drugs with new mechanisms to block HIV entry. The new therapies are being developed for both as add-on therapy to existing combination antiretroviral therapy and as agents to be used during treatment interruption...
September 19, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28929347/an-ethical-assessment-model-for-digital-disease-detection-technologies
#6
Kerstin Denecke
Digital epidemiology, also referred to as digital disease detection (DDD), successfully provided methods and strategies for using information technology to support infectious disease monitoring and surveillance or understand attitudes and concerns about infectious diseases. However, Internet-based research and social media usage in epidemiology and healthcare pose new technical, functional and formal challenges. The focus of this paper is on the ethical issues to be considered when integrating digital epidemiology with existing practices...
September 20, 2017: Life Sciences, Society and Policy
https://www.readbyqxmd.com/read/28929304/embryonic-body-culturing-in-an-all-glass-microfluidic-device-with-laser-processed-4%C3%A2-%C3%AE-m-thick-ultra-thin-glass-sheet-filter
#7
Y Yalikun, N Tanaka, Y Hosokawa, T Iino, Y Tanaka
In this paper, we report the development and demonstration of a method to fabricate an all-glass microfluidic cell culturing device without circulation flow. On-chip microfluidic cell culturing is an indispensable technique for cellular replacement therapies and experimental cell biology. Polydimethylsiloxane (PDMS) have become a popular material for fabricating microfluidic cell culture devices because it is a transparent, biocompatible, deformable, easy-to-mold, and gas-permeable. However, PDMS is also a chemically and physically unstable material...
September 19, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28929288/complex-organic-pollutant-mixtures-originating-from-industrial-and-municipal-emissions-in-surface-waters-of-the-megacity-jakarta-an-example-of-a-water-pollution-problem-in-emerging-economies
#8
Larissa Dsikowitzky, Lukas Hagemann, Dwiyitno, Farida Ariyani, Hari Eko Irianto, Jan Schwarzbauer
During the last decades, the global industrial production partly shifted from industrialized nations to emerging and developing countries. In these upcoming economies, the newly developed industrial centers are generally located in densely populated areas, resulting in the discharge of often only partially treated industrial and municipal wastewaters into the surface waters. There is a huge gap of knowledge about the composition of the complex organic pollutant mixtures occurring in such heavily impacted areas...
September 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28929096/contaminants-in-foods-of-animal-origin-in-cameroon-a-one-health-vision-for-risk-management-from-farm-to-fork
#9
REVIEW
Guy B Pouokam, B U Saha Foudjo, Chi Samuel, Philomina Fankam Yamgai, A Kamda Silapeux, Joel Taguemkam Sando, G Fankam Atonde, Chiara Frazzoli
Foods of animal origin represent an important share in the diet of Cameroonian populations. Cameroon is known to be a food basket in the west and central Africa sub-region, and an important supplier of foods on the international markets. In the meantime, food importation is continuously increasing to meet the high demand of a more westernized segment of the population. Cereals, fish, sea products, eggs, honey, shrimps, chicken, and feed ingredients are important share in the international trade of agricultural products...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28928908/epithelial-plasticity-and-cancer-stem-cells-major-mechanisms-of-cancer-pathogenesis-and-therapy-resistance
#10
REVIEW
Minal Garg
Epithelial-mesenchymal transition (EMT) has been linked with aggressive tumor biology and therapy resistance. It plays central role not only in the generation of cancer stem cells (CSCs) but also direct them across the multiple organ systems to promote tumor recurrence and metastasis. CSCs are reported to express stem cell genes as well as specific cell surface markers and allow aberrant differentiation of progenies. It facilitates cancer cells to leave primary tumor, acquire migratory characteristics, grow into new environment and develop radio-chemo-resistance...
August 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/28928112/influenzanet-citizens-among-10-countries-collaborating-to-monitor-influenza-in-europe
#11
Carl E Koppeschaar, Vittoria Colizza, Caroline Guerrisi, Clément Turbelin, Jim Duggan, W John Edmunds, Charlotte Kjelsø, Ricardo Mexia, Yamir Moreno, Sandro Meloni, Daniela Paolotti, Daniela Perrotta, Edward van Straten, Ana O Franco
BACKGROUND: The wide availability of the Internet and the growth of digital communication technologies have become an important tool for epidemiological studies and health surveillance. Influenzanet is a participatory surveillance system monitoring the incidence of influenza-like illness (ILI) in Europe since 2003. It is based on data provided by volunteers who self-report their symptoms via the Internet throughout the influenza season and currently involves 10 countries. OBJECTIVE: In this paper, we describe the Influenzanet system and provide an overview of results from several analyses that have been performed with the collected data, which include participant representativeness analyses, data validation (comparing ILI incidence rates between Influenzanet and sentinel medical practice networks), identification of ILI risk factors, and influenza vaccine effectiveness (VE) studies previously published...
September 19, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28928110/perceptions-of-patients-with-chronic-obstructive-pulmonary-disease-and-their-physiotherapists-regarding-the-use-of-an-ehealth-intervention
#12
Sigrid Vorrink, Chantal Huisman, Helianthe Kort, Thierry Troosters, Jan-Willem Lammers
BACKGROUND: If eHealth interventions are not used (properly), their potential benefits cannot be fulfilled. User perceptions of eHealth are an important determinant of its successful implementation. This study examined how patients with chronic obstructive pulmonary disease (COPD) and their physiotherapists (PHTs) value an eHealth self-management intervention following a period of use. OBJECTIVE: The study aimed to evaluate the perceptions of COPD patients and their PHTs as eHealth users...
September 19, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28927844/reliability-modelling-of-redundant-safety-systems-without-automatic-diagnostics-incorporating-common-cause-failures-and-process-demand
#13
Siamak Alizadeh, Srinivas Sriramula
Redundant safety systems are commonly used in the process industry to respond to hazardous events. In redundant systems composed of identical units, Common Cause Failures (CCFs) can significantly influence system performance with regards to reliability and safety. However, their impact has been overlooked due to the inherent complexity of modelling common cause induced failures. This article develops a reliability model for a redundant safety system using Markov analysis approach. The proposed model incorporates process demands in conjunction with CCF for the first time and evaluates their impacts on the reliability quantification of safety systems without automatic diagnostics...
September 16, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28927676/a-pilot-study-to-expand-treatment-of-chronic-hepatitis-c-in-resource-limited-settings
#14
REVIEW
Poonam Mathur, Emily Comstock, Edward McSweegan, Natalia Mercer, Nongthombam Suraj Kumar, Shyamasundaran Kottilil
The past five years have seen a revolution in the treatment of chronic hepatitis C, as short duration oral regimens of direct-acting antiviral drugs (DAAs), with nearly 100% cure rates for all genotypes, have replaced longer courses of ribavirin and injected interferon. Although initially very expensive, these DAAs are now becoming available in generic equivalents in countries with large numbers of chronically infected people, such as India. However, a number of obstacles may hinder the delivery of these drugs in resource-limited settings, including lack of access to diagnostic testing and the restriction of treatment to a small number of medical specialists...
September 16, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28926998/a-new-hydrogen-sensor-based-on-sns-fiber-interferometer-with-pd-wo%C3%A2-coating
#15
Jinxin Shao, Wenge Xie, Xi Song, Yanan Zhang
This paper presents a new hydrogen sensor based on a single mode-no core-single mode (SNS) fiber interferometer structure. The surface of the no core fiber (NCF) was coated by Pd/WO₃ film to detect the variation of hydrogen concentration. If the hydrogen concentration changes, the refractive index of the Pd/WO₃ film as well as the boundary condition for light propagating in the NCF will all be changed, which will then cause a shift into the resonant wavelength of interferometer. Therefore, the hydrogen concentration can be deduced by measuring the shift of the resonant wavelength...
September 18, 2017: Sensors
https://www.readbyqxmd.com/read/28926991/-found-performance-towards-a-musical-methodology-for-exploring-the-aesthetics-of-care
#16
Stuart Wood
Concepts of performance in fine art reflect key processes in music therapy. Music therapy enables practitioners to reframe patients as performers, producing new meanings around the clinical knowledge attached to medical histories and constructs. In this paper, music therapy practices are considered in the wider context of art history, with reference to allied theories from social research. Tracing a century in art that has revised the performativity of found objects (starting with Duchamp's "Fountain"), and of found sound (crystallised by Cage's 4' 33) this paper proposes that music therapy might be a pioneer methodology of "found performance"...
September 18, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28926952/medium-access-control-protocols-for-cognitive-radio-ad-hoc-networks-a-survey
#17
REVIEW
Mahdi Zareei, A K M Muzahidul Islam, Sabariah Baharun, Cesar Vargas-Rosales, Leyre Azpilicueta, Nafees Mansoor
New wireless network paradigms will demand higher spectrum use and availability to cope with emerging data-hungry devices. Traditional static spectrum allocation policies cause spectrum scarcity, and new paradigms such as Cognitive Radio (CR) and new protocols and techniques need to be developed in order to have efficient spectrum usage. Medium Access Control (MAC) protocols are accountable for recognizing free spectrum, scheduling available resources and coordinating the coexistence of heterogeneous systems and users...
September 16, 2017: Sensors
https://www.readbyqxmd.com/read/28926789/profiling-quinones-in-ambient-air-samples-collected-from-the-athabasca-region-canada
#18
Andrzej Wnorowski, Jean-Pierre Charland
This paper presents new findings on polycyclic aromatic hydrocarbon oxidation products-quinones that were collected in ambient air samples in the proximity of oil sands exploration. Quinones were characterized for their diurnal concentration variability, phase partitioning, and molecular size distribution. Gas-phase (GP) and particle-phase (PM) ambient air samples were collected separately in the summer; a lower quinone content was observed in the PM samples from continuous 24-h sampling than from combined 12-h sampling (day and night)...
September 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28926737/people-planet-and-profit-unintended-consequences-of-legacy-building-materials
#19
REVIEW
Anthony T Zimmer, HakSoo Ha
Although an explosion of new building materials are being introduced into today's market, adequate up-front research into their chemical and physical properties as well as their potential health and environmental consequences is lacking. History has provided us with several examples where building materials were broadly deployed into society only to find that health and environmental problems resulted in unintended sustainability consequences. In the following paper, we use lead and asbestos as legacy building materials to show their similar historical trends and sustainability consequences...
September 16, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28926227/vertically-stacked-and-self-encapsulated-van-der-waals-heterojunction-diodes-using-two-dimensional-layered-semiconductors
#20
Jinshui Miao, Zhihao Xu, Li Qing, Arthur Bowman, Suoming Zhang, Weida Hu, Zhixian Zhou, Chuan Wang
Van der Waals heterojunctions using 2D semiconducting materials could overcome the defect issues included by lattice mismatch in conventional epitaxially-grown heterojunctions with bulk materials and could enable a much wider palette for choice of materials and more sophisticated device design. Such 2D heterojunction devices are of great interest for important functional devices such as diodes, bipolar junction transistors, light-emitting diodes, and photodetectors. In this paper, we demonstrate a truly vertical p-n heterojunction diode built from 2D semiconductors (MoS2 and BP) and compare its performance against conventional lateral 2D heterojunction devices...
September 19, 2017: ACS Nano
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