keyword
MENU ▼
Read by QxMD icon Read
search

New papers

keyword
https://www.readbyqxmd.com/read/29150760/slow-passage-through-a-hopf-bifurcation-in-excitable-nerve-cables-spatial-delays-and-spatial-memory-effects
#1
L M Bilinsky, S M Baer
It is well established that in problems featuring slow passage through a Hopf bifurcation (dynamic Hopf bifurcation) the transition to large-amplitude oscillations may not occur until the slowly changing parameter considerably exceeds the value predicted from the static Hopf bifurcation analysis (temporal delay effect), with the length of the delay depending upon the initial value of the slowly changing parameter (temporal memory effect). In this paper we introduce new delay and memory effect phenomena using both analytic (WKB method) and numerical methods...
November 17, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29150319/analytical-design-of-an-industrial-two-term-controller-for-optimal-regulatory-control-of-open-loop-unstable-processes-under-operational-constraints
#2
Rodrigue Tchamna, Moonyong Lee
This paper proposes a novel optimization-based approach for the design of an industrial two-term proportional-integral (PI) controller for the optimal regulatory control of unstable processes subjected to three common operational constraints related to the process variable, manipulated variable and its rate of change. To derive analytical design relations, the constrained optimal control problem in the time domain was transformed into an unconstrained optimization problem in a new parameter space via an effective parameterization...
November 14, 2017: ISA Transactions
https://www.readbyqxmd.com/read/29150285/a-review-of-prevalence-studies-of-autism-spectrum-disorder-by-latitude-and-solar-irradiance-impact
#3
Somayya Syed, Kathleen A Moore, Evita March
Autism Spectrum Disorder (ASD) is a lifelong disability with no known cause or cure. Among the suggested etiologies, is Cannell's hypothesis of a deficiency in Vitamin D the main natural source of which is Solar Ultraviolet-B (UVB) radiation. The aim in this paper is to build on this hypothesis and explore the relationship of solar irradiance of which UVB is a component, by latitude with the prevalence rates of ASD. Twenty-five reports published between 2011 and 2016 using comparable diagnostic criteria were reviewed...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29150284/the-displacing-foods-of-modern-commerce-are-the-primary-and-proximate-cause-of-age-related-macular-degeneration-a-unifying-singular-hypothesis
#4
Chris A Knobbe, Marija Stojanoska
Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss and blindness in developed nations. AMD is anticipated to affect 196 million people worldwide, by 2020. However, the etiology of this disease remains unknown. Aging, genetic, and environmental influences have generally been implicated as major etiologic factors. We sought to examine the hypothesis that consumption of the 'displacing foods of modern commerce,' which equate to processed, nutrient-deficient and potentially toxic foods, may be the primary and proximate cause of AMD...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29150174/a-new-species-of-discocyrtanus-from-mato-grosso-brazil-opiliones-gonyleptidae-with-a-key-to-the-species-of-the-genus
#5
Rafael N Carvalho, Adriano B Kury
Discocyrtanus canjinjim sp. n., belonging to the family Gonyleptidae Sundevall, 1833 is described based on nineteen specimens, eleven adult males and eight adult females, collected in the Vila Bela da Santíssima Trindade, in the State of Mato Grosso, Brazil. This new species represents an endemic component for the harvestmen fauna of Chiquitano Dry Forests terrestrial eco-region, being the most occidental point of distribution of the genus, notably found in the Cerrado and the Atlantic Forest. The new species is characterized by femur IV swollen with the same length of dorsal scutum, trochanter IV with prodorsal distal apophysis as a stout hook not bifurcated, and a unique form of genitalia in the genus...
November 14, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29150144/atypical-depression-and-non-atypical-depression-is-hpa-axis-function-a-biomarker-a-systematic-review
#6
REVIEW
Mario F Juruena, Mariia Bocharova, Bruno Agustini, Allan H Young
BACKGROUND: The link between the abnormalities of the Hypothalamic-pituitary-adrenal (HPA) axis and depression has been one of the most consistently reported findings in psychiatry. At the same time, multiple studies have demonstrated a stronger association between the increased activation of HPA-axis and melancholic, or endogenous depression subtype. This association has not been confirmed for the atypical subtype, and some researchers have suggested that as an antinomic depressive subtype, it may be associated with the opposite type, i...
October 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29150090/graph-based-representation-of-behavior-in-detection-and-prediction-of-daily-living-activities
#7
Piotr Augustyniak, Grażyna Ślusarczyk
Various surveillance systems capture signs of human activities of daily living (ADLs) and store multimodal information as time line behavioral records. In this paper, we present a novel approach to the analysis of a behavioral record used in a surveillance system designed for use in elderly smart homes. The description of a subject's activity is first decomposed into elementary poses - easily detectable by dedicated intelligent sensors - and represented by the share coefficients. Then, the activity is represented in the form of an attributed graph, where nodes correspond to elementary poses...
November 10, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29149821/statins-therapy-for-connective-tissue-diseases-new-therapeutic-opportunities
#8
Przemyslaw J Kotyla, Eugene J Kucharz
Background and Objective Statins, 3-hydroxyl-3-methyl-glutharyl Coenzyme A reductase inhibitors showed their therapeutic potential in the treatment of atherosclerosis-related diseases. Recently, the properties of statins, separate from their lipid lowering activity have attracted much attention. These properties that cover a wide area of physiopathological activities including cell maturation, immune response regulation, tissue fibrosis, endothelial activity and are called pleiotropic activity. Many in vitro studies demonstrated significant, statins-dependent regulation of immune system reactivity, reduction of pro-inflammatory and pro-fibrotic cytokines as well as suppression of endothelial activity and damage...
November 15, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29149812/architectures-and-mechanical-properties-of-drugs-and-complexes-of-surface-active-compounds-at-air-water-and-oil-water-interfaces
#9
Dipak K Sarker
BACKGROUND: Drugs can represents a multitude of compounds from proteins and peptides, such as growth hormones and insulin and on to simple organic molecules such as flurbiprofen, ibuprofen and lidocaine. Given the chemical nature of these compounds two features are always present. A portion or portions of the molecule that has little affinity for apolar surfaces and media and the opposite a series of part or one large part that has considerable affinity for hydrophilic, polar or charged media and surfaces...
November 17, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29149725/a-method-for-the-design-of-ultrasonic-devices-for-scanning-acoustic-microscopy-using-impulsive-signals
#10
Mototaka Arakawa, Hiroshi Kanai, Kazuo Ishikawa, Ryo Nagaoka, Kazuto Kobayashi, Yoshifumi Saijo
Scanning acoustic microscopy (SAM) using impulsive signals is useful for characterization of biological tissues and cells. The operating center frequency of an ultrasonic device strongly depends on the performance characteristics of the device if the measurement is conducted by using impulsive signals. In this paper, a method for the design of ultrasonic devices for SAM using impulsive signals was developed. A new plane-wave model was introduced to calculate frequency characteristics of loss of ultrasonic devices by taking into account the conversion loss at the ultrasonic transducer, the transmission loss at the acoustic anti-reflection coating, and the propagation loss in the couplant...
November 2, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29149684/combining-benford-s-law-and-machine-learning-to-detect-money-laundering-an-actual-spanish-court-case
#11
Elena Badal-Valero, José A Alvarez-Jareño, Jose M Pavía
OBJECTIVES: This paper is based on the analysis of the database of operations from a macro-case on money laundering orchestrated between a core company and a group of its suppliers, 26 of which had already been identified by the police as fraudulent companies. In the face of a well-founded suspicion that more companies have perpetrated criminal acts and in order to make better use of what are very limited police resources, we aim to construct a tool to detect money laundering criminals...
November 11, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29149558/quantification-of-humic-substances-in-natural-water-using-nitrogen-doped-carbon-dots
#12
Yan-Fang Guan, Bao-Cheng Huang, Chen Qian, Han-Qing Yu
Dissolved organic matter (DOM) is ubiquitous in aqueous environments and plays a significant role in pollutant mitigation, transformation and organic geochemical circulation. DOM is also capable of forming carcinogenic by-products in the disinfection treatment processes of drinking water. Thus, efficient methods for DOM quantification are highly desired. In this work, a novel sensor for rapid and selective detection of humic substances (HS), a key component of DOM, based on fluorescence quenching of nitrogen-doped carbon quantum dots was developed...
November 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29149495/a-redox-activated-g-quadruplex-dna-binder-based-on-a-platinum-iv-salphen-complex
#13
Ramon Vilar, Stephane Bandeira, Jorge Gonzalez Garcia, Evangelina Pensa, Tim Albrecht
There has been increasing interest in the development of small molecules that can selectively bind to G-quadruplex DNA structures. The latter have been associated to a number of key biological processes and therefore are proposed to be potential targets for drug development. In this paper we report the first example of a reduction-activated G-quadruplex DNA binder. We show that a new octahedral platinum(IV)-salphen complex does not interact with DNA in aqueous media at pH 7.4; however, upon addition of bio-reductants such as ascorbic acid or glutathione, the compound readily reduces to the corresponding square planar platinum(II) complex...
November 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29149474/interventions-for-old-world-cutaneous-leishmaniasis
#14
REVIEW
Julio Heras-Mosteiro, Begoña Monge-Maillo, Mariona Pinart, Patricia Lopez Pereira, Emely Garcia-Carrasco, Pedro Campuzano Cuadrado, Ana Royuela, Irene Mendez Roman, Rogelio López-Vélez
BACKGROUND: Cutaneous leishmaniasis, caused by a parasitic infection, is considered one of the most serious skin diseases in many low- and middle-income countries. Old World cutaneous leishmaniasis (OWCL) is caused by species found in Africa, Asia, the Middle East, the Mediterranean, and India. The most commonly prescribed treatments are antimonials, but other drugs have been used with varying success. As OWCL tends to heal spontaneously, it is necessary to justify the use of systemic and topical treatments...
November 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29149331/the-ethics-of-organ-tourism-role-morality-and-organ-transplantation
#15
Marcus P Adams
Organ tourism occurs when individuals in countries with existing organ transplant procedures, such as the United States, are unable to procure an organ by using those transplant procedures in enough time to save their life. In this paper, I am concerned with the following question: When organ tourists return to the United States and need another transplant, do US transplant physicians have an obligation to place them on a transplant list? I argue that transplant physicians have a duty not to relist organ tourists...
November 15, 2017: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/29149325/the-iuphar-bps-guide-to-pharmacology-in-2018-updates-and-expansion-to-encompass-the-new-guide-to-immunopharmacology
#16
Simon D Harding, Joanna L Sharman, Elena Faccenda, Chris Southan, Adam J Pawson, Sam Ireland, Alasdair J G Gray, Liam Bruce, Stephen P H Alexander, Stephen Anderton, Clare Bryant, Anthony P Davenport, Christian Doerig, Doriano Fabbro, Francesca Levi-Schaffer, Michael Spedding, Jamie A Davies
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) and its precursor IUPHAR-DB, have captured expert-curated interactions between targets and ligands from selected papers in pharmacology and drug discovery since 2003. This resource continues to be developed in conjunction with the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS). As previously described, our unique model of content selection and quality control is based on 96 target-class subcommittees comprising 512 scientists collaborating with in-house curators...
November 15, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29149271/rangatahi-t%C3%A5-rangatira-innovative-health-promotion-in-aotearoa-new-zealand
#17
Christina Severinsen, Angelique Reweti
Rangatahi Tū Rangatira (R2R) is a national health promotion programme in Aotearoa New Zealand which aims to promote cultural and physical wellbeing for rangatahi (young people) and their whānau (family). Grounded in tikanga Māori, the programme focuses on total wellbeing, leadership and cultural awareness providing rangatahi opportunities to increase their participation in physical activity and cultural knowledge through ngā taonga tākaro (Māori ancestral games). This paper focuses on an evaluation of this innovative health promotion programme focussing on the delivery of R2R by a local iwi provider in a rural area...
November 14, 2017: Health Promotion International
https://www.readbyqxmd.com/read/29149217/per-service-supervised-learning-for-identifying-desired-wot-apps-from-user-requests-in-natural-language
#18
Young Yoon
Web of Things (WoT) platforms are growing fast so as the needs for composing WoT apps more easily and efficiently. We have recently commenced the campaign to develop an interface where users can issue requests for WoT apps entirely in natural language. This requires an effort to build a system that can learn to identify relevant WoT functions that fulfill user's requests. In our preceding work, we trained a supervised learning system with thousands of publicly-available IFTTT app recipes based on conditional random fields (CRF)...
2017: PloS One
https://www.readbyqxmd.com/read/29148727/substrate-assisted-in-situ-confinement-pyrolysis-of-zeolitic-imidazolate-frameworks-to-nitrogen-doped-hierarchical-porous-carbon-nanoframes-with-superior-lithium-storage
#19
Wei Tian, Jialiang Liu, Yixian Wang, Jingyan Liu, Yanpeng Li, Mingbo Wu
Porous carbons generated from the direct pyrolysis of metal organic frameworks (MOFs) have showed great potential as a kind of promising electrode materials for lithium-ion batteries (LIBs). However, several common drawbacks, such as the inevitable structural damage during carbonization process and intrinsic micropore-dominated feature of MOFs-derived products, largely impede the exposure of active sites and mass transfer, thus usually resulting in inferior electrochemical performances. In this work, an effective and controllable approach was reported to construct nitrogen-doped hierarchical porous carbon nanoframes (N-HPCFs) through in situ pyrolysis transformation of small-sized zeolitic imidazolate frameworks (ZIFs) that are in advance combined with a two-dimensional substrate templated from g-C3N4...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29148148/an-integrative-translational-approach-to-study-heart-failure-with-preserved-ejection-fraction-a-position-paper-from-the-working-group-on-myocardial-function-of-the-european-society-of-cardiology
#20
REVIEW
Andre P Lourenço, Adelino F Leite-Moreira, Jean-Luc Balligand, Johann Bauersachs, Dana Dawson, Rudolf A de Boer, Leon J de Windt, Inês Falcão-Pires, Ricardo Fontes-Carvalho, Stefan Franz, Mauro Giacca, Denise Hilfiker-Kleiner, Emilio Hirsch, Christoph Maack, Manuel Mayr, Burkert Pieske, Thomas Thum, Carlo G Tocchetti, Dirk L Brutsaert, Stephane Heymans
As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long-term clinical manifestations. We will revise recent advances in animal model development, experimental set-ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages...
November 16, 2017: European Journal of Heart Failure
keyword
keyword
106565
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"