Read by QxMD icon Read

New papers

Jordi Solé-Casals, Karmele López-de-Ipiña Pena, Cesar F Caiafa
This paper proposes a new method for blind inversion of a monotonic nonlinear map applied to a sum of random variables. Such kinds of mixtures of random variables are found in source separation and Wiener system inversion problems, for example. The importance of our proposed method is based on the fact that it permits to decouple the estimation of the nonlinear part (nonlinear compensation) from the estimation of the linear one (source separation matrix or deconvolution filter), which can be solved by applying any convenient linear algorithm...
2016: PloS One
A Tiril M Pedersen, Michael D Nowak, Anne K Brysting, Reidar Elven, Charlotte S Bjorå
Hybridization is frequent in the large and ecologically significant genus Carex (Cyperaceae). In four important sections of the northern regions (Ceratocystis, Glareosae, Phacocystis and Vesicariae), the frequent occurrence of hybrids often renders the identification of "pure" species and hybrids difficult. In this study we address the origins and taxonomic rank of two taxa of section Vesicariae: Carex rostrata var. borealis and C. stenolepis. The origin and taxonomic status of C. stenolepis has been the subject of substantial debate over the years, whereas C...
2016: PloS One
Ramnath Subbaraman, Ruvandhi R Nathavitharana, Srinath Satyanarayana, Madhukar Pai, Beena E Thomas, Vineet K Chadha, Kiran Rade, Soumya Swaminathan, Kenneth H Mayer
BACKGROUND: India has 23% of the global burden of active tuberculosis (TB) patients and 27% of the world's "missing" patients, which includes those who may not have received effective TB care and could potentially spread TB to others. The "cascade of care" is a useful model for visualizing deficiencies in case detection and retention in care, in order to prioritize interventions. METHODS AND FINDINGS: The care cascade constructed in this paper focuses on the Revised National TB Control Programme (RNTCP), which treats about half of India's TB patients...
October 2016: PLoS Medicine
James M Mutunga, Qiao-Hong Chen, Dawn M Wong, Polo C-H Lam, Jianyong Li, Maxim M Totrov, Aaron D Gross, Paul R Carlier, Jeffrey R Bloomquist
Widespread pyrethroid resistance has caused an urgent need to develop new insecticides for control of the malaria mosquito, Anopheles gambiae. Insecticide discovery efforts were directed towards the construction of bivalent inhibitors that occupy both the peripheral and catalytic sites of the mosquito acetylcholinesterase (AChE). It was hypothesized that this approach would yield a selective, high potency inhibitor that would also circumvent known catalytic site mutations (e.g. G119S) causing target site resistance...
October 2016: Chimia
Małgorzata Sadkowska-Todys, Andrzej Zieliński, Mirosław P Czarkowski
PURPOSE of the STUDY: The aim of the study is to assess epidemiological situation of infectious and parasitic diseases in Poland in 2014, and an indication of the potential health risks from communicable diseases occurring in other areas of the globe. MATERIAL AND METHODS: This paper is a summary of the analysis and evaluation of the results of epidemiological surveillance of infectious diseases in Poland in 2014, and those elements of European and global epidemiological background, which in this period had an impact on the epidemiological situation in Poland or constituted a threat...
2016: Przegla̧d Epidemiologiczny
Johan De Meester
From late nineteen nineties, the higher number of suitable renal transplant candidates has forced the transplant community to re-explore the whole spectrum of deceased donors after brain death (DBD) as well as after cardiac death (DCD); in practice, donors of older age and donors with more chronic diseases or "medical complexities". This new kidney donor population - finally defined as extended criteria donors (ECD) - currently comprises on average 20 to 25%. In his seminal paper in 2003 on the introduction of ECD in the US, Metzger et al...
October 25, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
Huan Yang, Li Zhang, Lei Jiao
Activation of the carbon-halogen bonds in aryl halides is a key step in transition-metal-free cross-coupling reactions. In this paper a new and efficient radical initiation system for the activation of iodoarenes to produce aryl radicals was discovered, which employed the combination of N-methylanilines and t-BuOK. This radical initiation system is robust and versatile, enabling various types of aryl radical-related reactions.
October 25, 2016: Chemistry: a European Journal
Rajkishen Narayanan, Hye Na Kim, Narayanan K Narayanan, Dominick Nargi, Bhagavathi Narayanan
Following the publication of this article, which was concerned with the expression of phosphorylated epidermal growth factor receptor (pEGFR) and cyclin D1 activation independently of the expression levels of cyclo-oxygenase-2, an interested reader drew to our attention apparent anomalies associated with the western blot data shown in Fig. 2C. Following an internal investigation at the New York University School of Medicine, we were requested to produce the original film, or the scan of the image of the film, for verification...
October 18, 2016: International Journal of Oncology
Xiaoshu Lü, Esa-Pekka Takala, Esko Toppila, Ykä Marjanen, Leena Kaila-Kangas, Tao Lu
Exposure to whole-body vibration (WBV) presents an occupational health risk and several safety standards obligate to measure WBV. The high cost of direct measurements in large epidemiological studies raises the question of the optimal sampling for estimating WBV exposures given by a large variation of exposure levels in real worksites. This paper presents a new approach to address this problem. A daily exposure to WBV was recorded for 9 to 24 days among 48 all-terrain vehicle drivers. Four datasets based on root mean squared recordings were obtained from the measurement...
October 25, 2016: Ergonomics
Magali Hernandez, Bérengère Phulpin, Ludovic Mansuy, Dominique Droz
New targeted cancer therapies such as bisphosphonates, denosumab and bevacizumab are routinely used in adult for the past decades. Their introduction into pediatric medicine is more recent that means there is a paucity of data on long-term effects on dental development and on the risk of osteonecrosis of jaw. This paper aims to outline adverse effects of new targeted cancer therapies on oral cavity including dental abnormalities observed in pediatric population treated with these molecules and the risk of osteonecrosis of the jaw (ONJ)...
October 25, 2016: Journal of Oral Pathology & Medicine
Dominic Micklewright, Sue Kegerreis, John Raglin, Florentina Hettinga
The extent to which athletic pacing decisions are made consciously or subconsciously is a prevailing issue. In this article we discuss why the one-dimensional conscious-subconscious debate that has reigned in the pacing literature has suppressed our understanding of the multidimensional processes that occur in pacing decisions. How do we make our decisions in real-life competitive situations? What information do we use and how do we respond to opponents? These are questions that need to be explored and better understood, using smartly designed experiments...
October 25, 2016: Sports Medicine
Rakesh Khilwani, Peter J Gilgunn, Takashi D Y Kozai, Xiao Chuan Ong, Emrullah Korkmaz, Pallavi K Gunalan, X Tracy Cui, Gary K Fedder, O Burak Ozdoganlar
Stable chronic functionality of intracortical probes is of utmost importance toward realizing clinical application of brain-machine interfaces. Sustained immune response from the brain tissue to the neural probes is one of the major challenges that hinder stable chronic functionality. There is a growing body of evidence in the literature that highly compliant neural probes with sub-cellular dimensions may significantly reduce the foreign-body response, thereby enhancing long term stability of intracortical recordings...
December 2016: Biomedical Microdevices
Carina Barbosa Pereira, Xinchi Yu, Michael Czaplik, Vladimir Blazek, Boudewijn Venema, Steffen Leonhardt
Diverse studies have demonstrated the importance of monitoring breathing rate (BR). Commonly, changes in BR are one of the earliest and major markers of serious complications/illness. However, it is frequently neglected due to limitations of clinically established measurement techniques, which require attachment of sensors. The employment of adhesive pads or thoracic belts in preterm infants as well as in traumatized or burned patients is an additional paramount issue. The present paper proposes a new robust approach, based on data fusion, to remotely monitor BR using infrared thermography (IRT)...
October 24, 2016: Journal of Clinical Monitoring and Computing
Behnoosh Parsa, Vladimir M Zatsiorsky, Mark L Latash
We address the nature of unintentional changes in performance in two papers. This second paper tested hypotheses related to stability of task-specific performance variables estimated using the framework of the uncontrolled manifold (UCM) hypothesis. Our first hypothesis was that selective stability of performance variables would be observed even when the magnitudes of those variables drifted unintentionally because of the lack of visual feedback. Our second hypothesis was that stability of a variable would depend on the number of explicit task constraints...
October 24, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Marshall B Jones
BACKGROUND: In the first decade of this century players in the National Football League, the NFL community, fans, even the public at large, became aware that multiple concussions, heretofore considered inconsequential, could have devastating consequences later in life. RESULTS: Since 1978, each one of the 32 teams in the NFL plays 16 games in the regular season. In the 25 years from 1978 to 2004 home advantage in the regular season tended to increase with Game Number (1-16)...
2016: SpringerPlus
Jun He, Yan-Min Liu, Hua Ke, Jun-Kang Tian, Xiang Li
In this paper, we have proposed some new upper bounds for the largest Z-eigenvalue of an irreducible weakly symmetric and nonnegative tensor, which improve the known upper bounds obtained in Chang et al. (Linear Algebra Appl 438:4166-4182, 2013), Song and Qi (SIAM J Matrix Anal Appl 34:1581-1595, 2013), He and Huang (Appl Math Lett 38:110-114, 2014), Li et al. (J Comput Anal Appl 483:182-199, 2015), He (J Comput Anal Appl 20:1290-1301, 2016).
2016: SpringerPlus
Gour Chand Daskhan, Carlo Pifferi, Olivier Renaudet
The synthesis of heteroglycoclusters (hGCs) is being subjected to rising interest, owing to their potential applications in glycobiology. In this paper, we report an efficient and straightforward convergent protocol based on orthogonal chemoselective ligations to prepare structurally well-defined cyclopeptide-based homo- and heterovalent glycoconjugates displaying 5-N-acetyl-neuraminic acid (Neu5Ac), galactose (Gal), and/or N-acetyl glucosamine (GlcNAc). We first used copper-catalyzed azide-alkyne cycloaddition and/or thiol-ene coupling to conjugate propargylated α-sialic acid 3, β-GlcNAc thiol 5, and β-Gal thiol 6 onto cyclopeptide scaffolds 7-9 to prepare tetravalent homoglycoclusters (10-12) and hGCs (13-14) with 2:2 combinations of sugars...
October 2016: ChemistryOpen
Peter E Ghaly, Rabab M Abou El-Magd, Cassandra D M Churchill, Jack A Tuszynski, F G West
Noscapine, a naturally occurring opium alkaloid, is a widely used antitussive medication. Noscapine has low toxicity and recently it was also found to possess cytotoxic activity which led to the development of many noscapine analogues. In this paper we report on the synthesis and testing of a novel noscapine analogue. Cytotoxicity was assessed by MTT colorimetric assay using SKBR-3 and paclitaxel-resistant SKBR-3 breast cancer cell lines using different concentrations for both noscapine and the novel compound...
June 28, 2016: Oncotarget
Sergey Alekhin, Wolfgang Altmannshofer, Takehiko Asaka, Brian Batell, Fedor Bezrukov, Kyrylo Bondarenko, Alexey Boyarsky, Ki-Young Choi, Cristóbal Corral, Nathaniel Craig, David Curtin, Sacha Davidson, André de Gouvêa, Stefano Dell'Oro, Patrick deNiverville, P S Bhupal Dev, Herbi Dreiner, Marco Drewes, Shintaro Eijima, Rouven Essig, Anthony Fradette, Björn Garbrecht, Belen Gavela, Gian F Giudice, Mark D Goodsell, Dmitry Gorbunov, Stefania Gori, Christophe Grojean, Alberto Guffanti, Thomas Hambye, Steen H Hansen, Juan Carlos Helo, Pilar Hernandez, Alejandro Ibarra, Artem Ivashko, Eder Izaguirre, Joerg Jaeckel, Yu Seon Jeong, Felix Kahlhoefer, Yonatan Kahn, Andrey Katz, Choong Sun Kim, Sergey Kovalenko, Gordan Krnjaic, Valery E Lyubovitskij, Simone Marcocci, Matthew Mccullough, David McKeen, Guenakh Mitselmakher, Sven-Olaf Moch, Rabindra N Mohapatra, David E Morrissey, Maksym Ovchynnikov, Emmanuel Paschos, Apostolos Pilaftsis, Maxim Pospelov, Mary Hall Reno, Andreas Ringwald, Adam Ritz, Leszek Roszkowski, Valery Rubakov, Oleg Ruchayskiy, Ingo Schienbein, Daniel Schmeier, Kai Schmidt-Hoberg, Pedro Schwaller, Goran Senjanovic, Osamu Seto, Mikhail Shaposhnikov, Lesya Shchutska, Jessie Shelton, Robert Shrock, Brian Shuve, Michael Spannowsky, Andy Spray, Florian Staub, Daniel Stolarski, Matt Strassler, Vladimir Tello, Francesco Tramontano, Anurag Tripathi, Sean Tulin, Francesco Vissani, Martin W Winkler, Kathryn M Zurek
This paper describes the physics case for a new fixed target facility at CERN SPS. The SHiP (search for hidden particles) experiment is intended to hunt for new physics in the largely unexplored domain of very weakly interacting particles with masses below the Fermi scale, inaccessible to the LHC experiments, and to study tau neutrino physics. The same proton beam setup can be used later to look for decays of tau-leptons with lepton flavour number non-conservation, [Formula: see text] and to search for weakly-interacting sub-GeV dark matter candidates...
December 2016: Reports on Progress in Physics
Jean-Baptiste Tylcz, Thierry Bastogne, Alexia Bourguignon, Celine Frochot, Muriel Barberi-Heyob
: Photodynamic therapy (PDT) is an alternative treatment for cancer that involves the administration of a photosensitizing agent, which is activated by light at a specific wavelength. This illumination causes after a sequence of photoreactions, the production of reactive oxygen species responsible for the death of the tumor cells but also the degradation of the photosensitizing agent, which then loose the fluorescence properties. The phenomenon is commonly known as photobleaching process and can be considered as a therapy efficiency indicator...
October 21, 2016: IEEE Transactions on Bio-medical Engineering
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"