Read by QxMD icon Read

compliance, persistence

Patrick J Buchanan, John A I Grossman, Andrew E Price, Chandan Reddy, Mustafa Chopan, Harvey Chim
BACKGROUND: Most brachial plexus birth injuries (BPBI) are caused by traction on the brachial plexus during a difficult delivery. Fortunately, the possibility of complete recovery from such an incident is relatively high, with only 10% to 30% of patients having prolonged and persistent disability. These patients have muscle imbalances and co-contractions typically localized around the shoulder and elbow. These imbalances and co-contractures cause abnormal motor performances and bone/joint deformities...
March 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
Benedetta Allegranzi, Alexander M Aiken, Nejla Zeynep Kubilay, Peter Nthumba, Jack Barasa, Gabriel Okumu, Robert Mugarura, Alexander Elobu, Josephat Jombwe, Mayaba Maimbo, Joseph Musowoya, Angèle Gayet-Ageron, Sean M Berenholtz
BACKGROUND: Surgical site infections (SSIs) are the most frequent health-care-associated infections in developing countries. Specific prevention measures are highly effective, but are often poorly implemented. We aimed to establish the effect of a multimodal intervention on SSIs in Africa. METHODS: We did a before-after cohort study, between July 1, 2013, and Dec 31, 2015, at five African hospitals. The multimodal intervention consisted of the implementation or strengthening of multiple SSI prevention measures, combined with an adaptive approach aimed at the improvement of teamwork and the safety climate...
March 5, 2018: Lancet Infectious Diseases
Katherine G Gold, Stacy Scofield, Steven R Isaacson, Michael W Stewart, Michael Kazim
PURPOSE: To evaluate the effectiveness of orbital radiotherapy (ORT) in the treatment of thyroid eye disease (TED)-compressive optic neuropathy. METHODS: A retrospective review of patients with corticosteroid-responsive compressive optic neuropathy due to TED treated with ORT. Study was conducted in compliance with Health Insurance Portability and Accountability Act. One hundred four patients (163 orbits) with a mean age of 61.7 years met inclusion criteria. Seventy-four percent (77/104) were female, and 32...
March 2018: Ophthalmic Plastic and Reconstructive Surgery
Johan Newell, Olivier Mairesse, Daniel Neu
PURPOSE: Until now, there is no clear consensus on optimal care for mild sleep-related breathing disorders (SRBD) in general or for positional obstructive sleep apnea (POSA) in particular. Most proposed treatment options are either invasive and/or expensive. Positional therapy (PT) may therefore present as a valuable first-line intervention in POSA. METHODS: Twenty-eight patients presenting with POSA were enrolled in a prospective cohort study. The protocol consisted of three nights of polysomnography (PSG) in an academic sleep lab...
March 7, 2018: Sleep & Breathing, Schlaf & Atmung
Sophie Lauzier, Hichem Kadachi, Jocelyne Moisan, Alain Vanasse, Alain Lesage, Marie-Josée Fleury, Jean-Pierre Grégoire
OBJECTIVE: To assess whether neighbourhood deprivation is associated with exposure to an antidepressant drug treatment (ADT) and its quality among individuals diagnosed with unipolar depression and insured by the Quebec public drug plan. METHOD: We conducted an administrative database cohort study of adults covered by the Quebec public drug plan who were diagnosed with a new episode of unipolar depression. We assessed material and social deprivation using an area-based index...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
Julian Hanske, Guido Müller, Arndt van Ophoven, Nicolas von Landenberg, Florian Roghmann, Rein-Jüri Palisaar, Christian von Bodman, Joachim Noldus, Marko Brock
AIMS: To examine the impact of Salvage lymph node dissection (SLND) on bladder function and oncological outcome in hormone naïve patients with nodal recurrence of prostate cancer (PCa) after radical prostatectomy (RP). METHODS: In a prospective study between October 2015 and November 2016, 20 patients underwent transperitoneal SLND for nodal recurrence of PCa after RP at our institution. Standardized urodynamics were performed pre- and postoperatively after 6 weeks, 3, and 6 to 12 months...
March 5, 2018: Neurourology and Urodynamics
Russell Knutsen, Scott C Beeman, Thomas J Broekelmann, Delong Liu, Kit Man Tsang, Attila Kovacs, Li Ye, Joshua Danback, Anderson Watson, Amanda Wardlaw, Jessica Wagenseil, Joel R Garbow, Michael Shoykhet, Beth A Kozel
Increased vascular stiffness correlates with higher risk of cardiovascular complications in aging adults. Elastin insufficiency, as observed in patients with Williams-Beuren syndrome or with familial supravalvular aortic stenosis, also increases vascular stiffness and leads to arterial narrowing. We used Eln+/- mice to test the hypothesis that pathologically increased vascular stiffness with concomitant arterial narrowing leads to decreased blood flow to end organs such as the brain. We also hypothesized that drugs which remodel arteries and increase lumen diameter would improve flow...
March 2, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Monica Neri, Luigi Sansone, Luisa Pietrasanta, Aliaksei Kisialiou, Eloisa Cabano, Marina Martini, Matteo A Russo, Donatella Ugolini, Marco Tafani, Stefano Bonassi
Background: Chronic rhinitis, pharyngitis and sinusitis are common health problems with a significant impact on public health, and are suspected to be influenced by ageing factors. Nasal inhalation with thermal water may be used to reduce symptoms, inflammation and drug intake. A pre-post clinical study was conducted in 183 consecutive adult and elderly patients with chronic rhinitis, pharyngitis or sinusitis, to evaluate whether thermal water nasal inhalations could improve their symptoms, clinical signs and rhinomanometry measurements, and influence inflammatory biomarkers levels in nasal epithelial cells...
2018: Immunity & Ageing: I & A
Hamida Kwas, Ines Zendah, Habib Ghedira
INTRODUCTION: Spontaneous pneumothorax (SP) is a frequent complication of pulmonary tuberculosis (TB) and a severe form of the disease. In spite of the fact that TB is a common cause of pneumothorax, a very few series, have been reported. METHODS: We retrospectively analysed the experience of SP secondary to TB in patients who were hospitalized in our department between 2005 and 2015. RESULTS: The mean age of patients was 38,5±19 years. Two patients had a history of pulmonary tuberculosis...
April 2017: La Tunisie Médicale
Karoliina Tainio, Antonios Athanasiou, Kari A O Tikkinen, Riikka Aaltonen, Jovita Cárdenas, Hernándes, Sivan Glazer-Livson, Maija Jakobsson, Kirsi Joronen, Mari Kiviharju, Karolina Louvanto, Sanna Oksjoki, Riikka Tähtinen, Seppo Virtanen, Pekka Nieminen, Maria Kyrgiou, Ilkka Kalliala
OBJECTIVE: To estimate the regression, persistence, and progression of untreated cervical intraepithelial neoplasia grade 2 (CIN2) lesions managed conservatively as well as compliance with follow-up protocols. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Medline, Embase, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) from 1 January 1973 to 20 August 2016. ELIGIBILITY CRITERIA: Studies reporting on outcomes of histologically confirmed CIN2 in non-pregnant women, managed conservatively for three or more months...
February 27, 2018: BMJ: British Medical Journal
Rebecca L Bartles, James E Leggett, Shannan Hove, Catherine D Kashork, Lian Wang, Margret Oethinger, Lynda Baxter, Jack J Brandabur
BACKGROUND AND AIMS: In a pilot study (8) we demonstrated that current guidelines for duodenoscope and linear echoendoscope (DLE) reprocessing using a single cycle of high-level disinfection (HLD) in an automated reprocessor may be inadequate. In August 2015, the FDA offered double-HLD as a possible response to address this concern. As a result, Providence Health & Services adopted double-HLD as standard procedure for DLE, but no rigorous clinical studies supported this practice. We undertook a quality improvement (QI) study to compare single-HLD versus double-HLD at 4 of our 34 hospitals...
February 21, 2018: Gastrointestinal Endoscopy
A Namugowa, J Iputo, J Wandabwa, A Meeme, G A B Buga, S Abura, Y Y Stofile
Women with pre-eclampsia have an increased risk of cardiovascular disease later in life. The aim of the study was to establish the presence and pattern of arterial stiffness in women previously with pre-eclampsia from a semi-rural region of South Africa. This was a prospective longitudinal study which involved 36 previously pre-eclamptic women and 86 non-pregnant controls (NPC) who had a past history of non-complicated pregnancy. Maternal wave reflection (augmentation index) and carotid-femoral pulse wave velocity were assessed noninvasively, using applanation tonometry with the SphygmoCor device...
February 23, 2018: Clinical and Experimental Hypertension: CHE
Carmine Zoccali, Francesca Mallamaci
Intention-to-treat and per-protocol analyses provide complementary information about the usefulness of therapies. While intention-to-treat analyses of trials that tested low-protein diets remain debated, per-protocol analyses of the same trials show that low protein intake actually reduces the risk of kidney failure. Per-protocol analyses are notoriously open to bias but intention-to-treat analyses are less immaculate than commonly realized because they critically depend on adherence to the treatment being tested and therefore may not be directly relevant for informing clinical decisions when different degrees of adherence to therapy occur...
February 19, 2018: Nephrology, Dialysis, Transplantation
Hilary Z Hu, Nicolas Granger, S Balakrishna Pai, Ravi V Bellamkonda, Nick D Jeffery
Many hundreds of thousands of people around the world are living with the long-term consequences of spinal cord injury and they need effective new therapies. Laboratory research in experimental animals has identified a large number of potentially translatable interventions but transition to the clinic is not straightforward. Further evidence of efficacy in more clinically-relevant lesions is required to gain sufficient confidence to commence human clinical trials. Of the many therapeutic candidates currently available, intraspinally applied chondroitinase ABC has particularly well documented efficacy in experimental animals...
February 9, 2018: Brain: a Journal of Neurology
Collins S K Ahorlu, Eric Koka, Susan Adu-Amankwah, Joseph Otchere, Dziedzom Komi de Souza
BACKGROUND: The Global Program for the Elimination of Lymphatic Filariasis (GPELF) started operation in 2000 and aimed at eliminating the disease by the year 2020, following 5-6 rounds of effective annual Mass Drug Administration (MDA). The MDA programme took off in Ghana in 2001 and has interrupted transmission in many areas while it has persisted in some areas after 10 or more rounds of MDA. This study was to appreciate community members' perspectives on MDA after over 15 years of implementation...
February 13, 2018: BMC Public Health
C Errando-Smet, C Müller-Arteaga, M Hernández, M Roset
OBJECTIVES: To explore the management of lower urinary tract symptoms(LUTS) in men in Spain and assess the compliance with recommendationsestablished in the European Association of Urology (EAU) guidelines. MATERIAL AND METHODS: MERCURY was an epidemiological and cross-sectionalstudy which involved 227 Urology Units across Spain assessing adult malepatients with mixed LUTS and persisting storage symptoms.Sociodemographic, clinical and resource use data for the 6 months priorto study inclusion were collected...
February 7, 2018: Actas Urologicas Españolas
Natacha Biset, Mélanie Lelubre, Christelle Senterre, Karim Amighi, Olivier Bugnon, Marie P Schneider, Carine De Vriese
Purpose: The aims of the study were to evaluate medication adherence and the influencing factors for isotretinoin and contraception (oral, patches, and rings) and to evaluate the concomitant use of contraception and isotretinoin. Methods: Reimbursed prescription data from January 2012 to August 2015 of all patients in Belgium were received from Pharmanet-National Institute for Health and Disability Insurance. Medication adherence was measured according to the medication possession ratio...
2018: Patient Preference and Adherence
Christine Greene, Nancy Hernandez Ceron, Marisa C Eisenberg, James Koopman, Jesse D Miller, Chuanwu Xi, Joseph N S Eisenberg
BACKGROUND: Healthcare-associated infections (HAIs) affect millions of patients every year. Pathogen transmission via fomites and healthcare workers (HCWs) contribute to the persistence of HAIs in hospitals. A critical parameter needed to assess risk of environmental transmission is the pathogen transfer efficiency between fomites and fingers. Recent studies have shown that pathogen transfer is not symmetric. In this study,we evaluated how the commonly used assumption of symmetry in transfer efficiency changes the dynamics of pathogen movement between patients and rooms and the exposures to uncolonized patients...
January 31, 2018: American Journal of Infection Control
Orna Steinberg-Shemer, Joanne Yacobovich, Miriam Cohen, Ioav Z Cabantchik, Hannah Tamary
Poor adherence of transfusion-dependent patients to chelation treatment is often the cause of persistent iron overload and ensuing morbidity. However, a tool to assess patient compliance with therapy is lacking in clinical practice. Labile plasma iron (LPI, the redox-active component of non-transferrin bound iron) has been studied as an indicator of systemic iron overload and of chelation efficacy, and may particularly reflect recent iron equilibrium. We considered the use of LPI as a potential indicator for recent chelation treatment in 18 transfusion-dependent pediatric patients...
January 23, 2018: Blood Cells, Molecules & Diseases
Juliana Guimarães Santos, Wanise Maria Souza Da Cruz, Axel H Schönthal, Marcela D'alincourt Salazar, Cristina Asvolinsque Pantaleão Fontes, Thereza Quirico-Santos, Clovis Orlando Da Fonseca
It has been hypothesized that persistent ketotic hypoglycemia represents a potential therapeutic strategy against high-grade gliomas. Perillyl alcohol (POH) is a non-toxic, naturally-occurring, hydroxylated monoterpene that exhibits cytotoxicity against temozolomide-resistant glioma cells, regardless of O6-methylguanine-methyltransferase promoter methylation status. The present study aimed to evaluate the toxicity and therapeutic efficacy of intranasal POH when administered in combination with a ketogenic diet (KD) program for the treatment of patients with recurrent glioblastoma...
January 2018: Oncology Letters
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"