Maria Kulecka, Edyta Waker, Filip Ambrozkiewicz, Agnieszka Paziewska, Karolina Skubisz, Patrycja Cybula, Łukasz Targoński, Michał Mikula, Jan Walewski, Jerzy Ostrowski
BACKGROUND: Clostridium difficile (C. difficile) is a major source of healthcare-associated infection with a high risk of recurrence, attributable to many factors such as usage of antibiotics, older age and immunocompromised status of the patients. C. difficile has also a highly diverse genome, which may contribute to its high virulence. Herein we examined whether the genome conservation, measured as non-synonymous to synonymous mutations ratio (dN/dS) in core genes, presence of single genes, plasmids and prophages increased the risk of reinfection in a subset of 134 C...
January 28, 2021: BMC Microbiology