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https://www.readbyqxmd.com/read/28424161/response-and-progression-on-midostaurin-in-advanced-systemic-mastocytosis-kit-d816v-and-other-molecular-markers
#1
Mohamad Jawhar, Juliana Schwaab, Nicole Naumann, Hans-Peter Horny, Karl Sotlar, Torsten Haferlach, Georgia Metzgeroth, Alice Fabarius, Peter Valent, Wolf-Karsten Hofmann, Nicholas C P Cross, Manja Meggendorfer, Andreas Reiter
In advanced systemic mastocytosis (advSM), disease evolution is often triggered by activating KIT mutations (D816V in >80% of cases) and by additional mutations, e.g. in SRSF2, ASXL1 and/or RUNX1 (S/A/R(pos), >60% of cases). In a recently reported phase-II-study, midostaurin, a multikinase/KIT inhibitor, demonstrated an overall response rate (ORR) of 60% in advSM but biomarkers predictive of response are lacking. We evaluated the impact of molecular markers (KIT D816V, S/A/R(pos)) at baseline and during follow-up in 38 midostaurin-treated advSM patients...
April 19, 2017: Blood
https://www.readbyqxmd.com/read/28412621/xanthium-strumarium-l-seed-hull-as-a-zero-cost-alternative-for-rhodamine-b-dye-removal
#2
Shraddha Khamparia, Dipika Kaur Jaspal
Treatment of polluted water has been considered as one of the most important aspects in environmental sciences. Present study explores the decolorization potential of a low cost natural adsorbent Xanthium strumarium L. seed hull for the adsorption of a toxic xanthene dye, Rhodamine B (RHB). The characterization of the adsorbent revealed the presence of high amount of carbon, when exposed to Electron Dispersive Spectroscopy (EDS). Further appreciable decolorization took place which was confirmed by Fourier Transform Infrared Spectroscopy (FTIR) analysis noticing shift in peaks...
April 13, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28334923/validated-rp-hplc-dad-method-for-the-quantification-of-insect-repellent-ethyl-2-aminobenzoate-in-membrane-moderated-matrix-type-monolithic-polymeric-device
#3
Johirul Islam, Kamaruz Zaman, Srijita Chakrabarti, Nilutpal Sharma Bora, Santa Mandal, Manash Pratim Pathak, Pakalapati Srinivas Raju, Pronobesh Chattopadhyay
A simple, accurate and sensitive reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the estimation of ethyl 2-aminobenzoate (EAB) in a matrix type monolithic polymeric device and validated as per the International Conference on Harmonization guidelines. The analysis was performed isocratically on a ZORBAX Eclipse plus C18 analytical column (250 × 4.4 mm, 5 μm) and a diode array detector (DAD) using acetonitrile and water (75:25 v/v) as the mobile phase by keeping the flow-rate constant at 1...
March 14, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28273578/polarity-inversion-of-bioanode-for-biocathodic-reduction-of-aromatic-pollutants
#4
Hui Yun, Bin Liang, De-Yong Kong, Hao-Yi Cheng, Zhi-Ling Li, Ya-Bing Gu, Hua-Qun Yin, Ai-Jie Wang
The enrichment of specific pollutant-reducing consortium is usually required prior to the startup of biocathode bioelectrochemical system (BES) and the whole process is time consuming. To rapidly establish a non-specific functional biocathode, direct polar inversion from bioanode to biocathode is proposed in this study. Based on the diverse reductases and electron transfer related proteins of anode-respiring bacteria (ARB), the acclimated electrochemically active biofilm (EAB) may catalyze reduction of different aromatic pollutants...
February 27, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28255172/reaching-back-the-relative-strength-of-the-retroactive-emotional-attentional-blink
#5
Áine Ní Choisdealbha, Richard M Piech, John K Fuller, David H Zald
Visual stimuli with emotional content appearing in close temporal proximity either before or after a target stimulus can hinder conscious perceptual processing of the target via an emotional attentional blink (EAB). This occurs for targets that appear after the emotional stimulus (forward EAB) and for those appearing before the emotional stimulus (retroactive EAB). Additionally, the traditional attentional blink (AB) occurs because detection of any target hinders detection of a subsequent target. The present study investigated the relations between these different attentional processes...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28214586/mango-kernel-starch-gum-composite-films-physical-mechanical-and-barrier-properties
#6
Anjum Nawab, Feroz Alam, Muhammad Abdul Haq, Zubala Lutfi, Abid Hasnain
Composite films were developed by the casting method using mango kernel starch (MKS) and guar and xanthan gums. The concentration of both gums ranged from 0% to 30% (w/w of starch; db). Mechanical properties, oxygen permeability (OP), water vapor permeability (WVP), solubility in water and color parameters of composite films were evaluated. The crystallinity and homogeneity between the starch and gums were also evaluated by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The scanning electron micrographs showed homogeneous matrix, with no signs of phase separation between the components...
May 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28163130/improved-thermal-stability-and-mechanical-properties-of-type-i-collagen-by-crosslinking-with-casein-keratin-and-soy-protein-isolate-using-transglutaminase
#7
Xiaomeng Wu, Yaowei Liu, Anjun Liu, Wenhang Wang
The inferior thermal- stability of collagen hinders its extensive application in food industry, including edible packaging. To improve the thermal- stability and mechanical properties of collagen, we attempted to crosslink collagen with some proteins possessing excellent thermal stability (i. e., casein, keratin and soy protein isolate (SPI)). Observed from the SDS- PAGE and particle size distribution, some complexes with higher molecule weight and relative bigger size particle occurred in the protein mixture, especially after TGase crosslinking...
May 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28107618/carbon-hollow-microspheres-with-a-designable-mesoporous-shell-for-high-performance-electromagnetic-wave-absorption
#8
Hailong Xu, Xiaowei Yin, Meng Zhu, Meikang Han, Zexin Hou, Xinliang Li, Litong Zhang, Laifei Cheng
In this work, mesoporous carbon hollow microspheres (PCHMs) with designable mesoporous shell and interior void are constructed by a facile in situ stöber templating approach and a pyrolysis-etching process. The PCHMs are characterized by scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectra, Raman spectroscopy, and nitrogen adsorption and desorption system. A uniform mesoporous shell (pore size 4.7 nm) with a thickness of 55 nm and a cavity size of 345 nm is realized. The composite of paraffin mixed with 20 wt % PCHMs exhibits a minimum reflection coefficient (RCmin) of -84 dB at 8...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28077134/endoscopy-assisted-surgery-for-the-management-of-benign-breast-tumors-technique-learning-curve-and-patient-reported-outcome-from-preliminary-323-procedures
#9
Hung-Wen Lai, Hui-Yu Lin, Shu-Ling Chen, Shou-Tung Chen, Dar-Ren Chen, Shou-Jen Kuo
BACKGROUND: Endoscopy-assisted breast surgery (EABS), a technique that optimizes cosmetic outcome because it is performed through small wounds hidden in inconspicuous areas, could be an alternative surgical technique for benign breast tumors. In this study, we report the preliminary results of 323 EABS procedures performed at our institution for the management of benign breast tumors. METHODS: The medical records of patients who underwent EABS for benign breast lesions during the periods August 2010 to December 2015 were collected from the Changhua Christian Hospital EABS database...
January 11, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28034703/hybrid-treatment-expanding-the-armamentarium-for-infected-infrarenal-abdominal-aortic-and-iliac-aneurysms
#10
Kichang Han, Do Yun Lee, Man-Deuk Kim, Sak Lee, Jong Yun Won, Joon Ho Kwon, Donghoon Choi, Young-Guk Ko
PURPOSE: To investigate safety and efficacy of hybrid treatment for infected aortic and iliac aneurysms. MATERIALS AND METHODS: Between July 2007 and May 2011, hybrid treatment was performed in 6 male patients (mean age, 67.7 y; range, 57-76 y). Hybrid treatment consisted of extraanatomic bypass (EAB) and isolation of infected aneurysm with vascular plugs. Aneurysms were divided into primary and secondary infected aneurysms. Primary infected aneurysm refers to an aneurysm arising from bacterial infection of the native arterial wall; secondary infected aneurysm refers to infection involving an aneurysm that was previously treated with graft placement...
December 26, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27996090/eco-friendly-biorefractory-films-of-gelatin-and-tempo-oxidized-cellulose-ester-for-food-packaging-application
#11
Furong Tao Chen Zhuang, Yuezhi Cui
BACKGROUND: Recent years, many types of food packing films and composites have been prepared by using gelatin due to its good film-forming ability, non-toxic nature and cost-effective. However, the relatively weak thermal stability, poor mechanical properties and easily-degradable quality limit the potential application of gelatin as a practical material. Microcrystalline cellulose (MCC), as one of the most abundant biomass resources, has been regarded as safe and reliable food additives because the same ingredients with the cellulose of people's daily intake...
December 20, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27987659/optimization-of-crosslinked-poly-vinyl-alcohol-nanocomposite-films-for-mechanical-properties
#12
Milad Rouhi, Seyed Hadi Razavi, Seyed Mohammad Mousavi
The effects of glycerol, bacterial cellulose nanocrystal (BCNC) and boric acid concentrations on the mechanical properties of PVA based films, including ultimate tensile strength (UTS), elongation at break (EAB), tensile Young's modulus (TYM), tensile toughness to break (TT), ultimate puncture strength (UPS), puncture deformation (PD), puncture Young's modulus (PYM) and puncture toughness to break (PT), were scrutinized using a response surface methodology-central composite rotatable design (RSM-CCRD). Second-order polynomial models with high R(2) values ranging from 0...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27877110/forward-genetic-screen-in-caenorhabditis-elegans-suggests-f57a10-2-and-acp-4-as-suppressors-of-c9orf72-related-phenotypes
#13
Xin Wang, Limin Hao, Taixiang Saur, Katelyn Joyal, Ying Zhao, Desheng Zhai, Jie Li, Mochtar Pribadi, Giovanni Coppola, Bruce M Cohen, Edgar A Buttner
An abnormally expanded GGGGCC repeat in C9ORF72 is the most frequent causal mutation associated with amyotrophic lateral sclerosis (ALS)/frontotemporal lobar degeneration (FTLD). Both gain-of-function (gf) and loss-of-function (lf) mechanisms have been involved in C9ORF72 related ALS/FTLD. The gf mechanism of C9ORF72 has been studied in various animal models but not in C. elegans. In the present study, we described mutant C9ORF72 modeling in C. elegans and report the finding of two suppressor genes. We made transgenes containing 9 or 29 repeats of GGGGCC in C9ORF72, driven by either the hsp-16 promoters or the unc-119 promoter...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27869299/anaerobic-reduction-of-2-6-dinitrotoluene-by-shewanella-oneidensis-mr-1-roles-of-mtr-respiratory-pathway-and-nfnb
#14
Dong-Feng Liu, Di Min, Lei Cheng, Feng Zhang, Dao-Bo Li, Xiang Xiao, Guo-Ping Sheng, Han-Qing Yu
Dinitrotoluene (DNT) is a widely present pollutant in aquatic environments, and its biodegradation is an economically attractive way to effectively removal. In aquatic environments, the presence of electrochemically active bacteria (EAB) could contribute to the anaerobic bioreduction of DNT. However, the mechanism behind such a biodegradation process at gene level remains to be further elucidated. In this work, the anaerobic reduction of 2,6-dinitrotoluene (2,6-DNT) by Shewanella oneidensis MR-1, a typical EAB in aquatic environments, was investigated...
November 7, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27835761/correlation-between-circuital-current-cu-ii-reduction-and-cellular-electron-transfer-in-eab-isolated-from-cu-ii-reduced-biocathodes-of-microbial-fuel-cells
#15
Jingya Shen, Liping Huang, Peng Zhou, Xie Quan, Gianluca Li Puma
The performance of four indigenous electrochemically active bacteria (EAB) (Stenotrophomonas maltophilia JY1, Citrobacter sp. JY3, Pseudomonas aeruginosa JY5 and Stenotrophomonas sp. JY6) was evaluated for Cu(II) reduction on the cathodes of microbial fuel cells (MFCs). These EAB were isolated from well adapted mixed cultures on the MFC cathodes operated for Cu(II) reduction. The relationship between circuital current, Cu(II) reduction rate, and cellular electron transfer processes was investigated from a mechanistic point of view using X-ray photoelectron spectroscopy, scanning electronic microscopy coupled with energy dispersive X-ray spectrometry, linear sweep voltammetry and cyclic voltammetry...
April 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/27746780/recent-progress-toward-engineering-hiv-1-specific-neutralizing-monoclonal-antibodies
#16
Ming Sun, Yue Li, Huiwen Zheng, Yiming Shao
The recent discoveries of broadly potent neutralizing human monoclonal antibodies represent a new generation of antiretrovirals for the treatment and prophylaxis. Antibodies are generally considered more effective and safer and have been proved to provide passive protection against mucosal challenge in humanized mice and macaques. Several neutralizing Abs could protect animals against HIV-1 but are not effective when used in an established infected model for therapy. In order to overcome the limitation of antiviral activities, multiple antibody-engineering technologies have been explored to generate "the better" neutralizing antibodies against HIV-1 since bNAbs attack viral entry by various mechanisms...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27746664/national-human-research-ethics-a-preliminary-comparative-case-study-of-germany-great-britain-romania-and-sweden
#17
Bernard Gallagher, Anne H Berman, Justyna Bieganski, Adele D Jones, Liliana Foca, Ben Raikes, Johanna Schiratzki, Mirjam Urban, Sara Ullman
Although international research is increasing in volume and importance, there remains a dearth of knowledge on similarities and differences in "national human research ethics" (NHREs), that is, national ethical guidelines (NEGs), Institutional Review Boards (IRBs), and research stakeholder' ethical attitudes and behaviors (EABs). We begin to address this situation by reporting upon our experiences in conducting a multinational study into the mental health of children who had a parent/carer in prison. The study was conducted in 4 countries: Germany, Great Britain, Romania, and Sweden...
October 2, 2016: Ethics & Behavior
https://www.readbyqxmd.com/read/27645927/characterization-of-rice-starch-%C3%AE-carrageenan-biodegradable-edible-film-effect-of-stearic-acid-on-the-film-properties
#18
Rahul Thakur, Bahareh Saberi, Penta Pristijono, John Golding, Costas Stathopoulos, Christopher Scarlett, Michael Bowyer, Quan Vuong
The main aim of this study was to develop rice starch (RS), ι-carrageenan (ι-car) based film. Different formulations of RS (1-4%, w/w), ι-car (0.5-2%, w/w) was blended with stearic acid (SA; 0.3-0.9%, w/w) and glycerol (1%, w/w) as a plasticizer. The effect of film ingredients on the thickness, water vapour permeability (WVP), film solubility (FS), moisture content (MC), colour, film opacity (FO), tensile strength (TS), elongation-at-break (EAB) of film was examined. Interactions and miscibility of partaking components was studied by using Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD)...
December 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27609094/anodic-biofilms-as-the-interphase-for-electroactive-bacterial-growth-on-carbon-veil
#19
Kateryna Artyushkova, Dan Roizman, Carlo Santoro, Lucinda Elizabeth Doyle, Abeed Fatima Mohidin, Plamen Atanassov, Enrico Marsili
The structure and activity of electrochemically active biofilms (EABs) are usually investigated on flat electrodes. However, real world applications such as wastewater treatment and bioelectrosynthesis require tridimensional electrodes to increase surface area and facilitate EAB attachment. The structure and activity of thick EABs grown on high surface area electrodes are difficult to characterize with electrochemical and microscopy methods. Here, the authors adopt a stacked electrode configuration to simulate the high surface and the tridimensional structure of an electrode for large-scale EAB applications...
2016: Biointerphases
https://www.readbyqxmd.com/read/27589953/the-green-ash-transcriptome-and-identification-of-genes-responding-to-abiotic-and-biotic-stresses
#20
Thomas Lane, Teodora Best, Nicole Zembower, Jack Davitt, Nathan Henry, Yi Xu, Jennifer Koch, Haiying Liang, John McGraw, Stephan Schuster, Donghwan Shim, Mark V Coggeshall, John E Carlson, Margaret E Staton
BACKGROUND: To develop a set of transcriptome sequences to support research on environmental stress responses in green ash (Fraxinus pennsylvanica), we undertook deep RNA sequencing of green ash tissues under various stress treatments. The treatments, including emerald ash borer (EAB) feeding, heat, drought, cold and ozone, were selected to mimic the increasing threats of climate change and invasive pests faced by green ash across its native habitat. RESULTS: We report the generation and assembly of RNA sequences from 55 green ash samples into 107,611 putative unique transcripts (PUTs)...
2016: BMC Genomics
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