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https://www.readbyqxmd.com/read/27776257/fatal-coronary-sinus-thrombosis-due-to-hypercoagulability-in-crohn-s-disease
#1
Janet Martin, Vidhya Nair, Allison Edgecombe
A 27-year-old male, admitted to hospital for a psoas muscle abscess secondary to Crohn's disease, suddenly died while in hospital. A medicolegal autopsy showed coronary sinus thrombosis. Coronary sinus thrombosis is rare and is usually associated with invasive cardiac procedures. Coronary sinus thrombosis associated with Crohn's disease has not been reported. Autopsy examination of the coronary sinus is advocated, especially in individuals with hypercoagulable states.
October 6, 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/27632993/surrogate-assisted-feature-extraction-for-high-throughput-phenotyping
#2
Sheng Yu, Abhishek Chakrabortty, Katherine P Liao, Tianrun Cai, Ashwin N Ananthakrishnan, Vivian S Gainer, Susanne E Churchill, Peter Szolovits, Shawn N Murphy, Isaac S Kohane, Tianxi Cai
OBJECTIVE: Phenotyping algorithms are capable of accurately identifying patients with specific phenotypes from within electronic medical records systems. However, developing phenotyping algorithms in a scalable way remains a challenge due to the extensive human resources required. This paper introduces a high-throughput unsupervised feature selection method, which improves the robustness and scalability of electronic medical record phenotyping without compromising its accuracy. METHODS: The proposed Surrogate-Assisted Feature Extraction (SAFE) method selects candidate features from a pool of comprehensive medical concepts found in publicly available knowledge sources...
September 15, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27522671/imparied-retrobulbar-blood-flow-and-increased-carotid-imt-in-patients-with-crohn-s-disease
#3
Zuhal Caliskan, Nursen Keles, Resul Kahraman, Kamil Özdil, Vildan Karagoz, Feyza Aksu, Gonul Aciksari, Yusuf Yilmaz, Seref Kul, Mustafa Caliskan
Crohn's Disease [CD] is one of the Inflammatory Bowel Diseases that are chronic relapsing inflammatory diseases. Despite the major affected organ is intestine in CD, extra intestinal organs and tissues including cardiovascular system are also affected. Several studies have demonstrated that CD patients may have a higher risk of advancing atherosclerosis. The microvascular endothelial dysfunction plays an essential role for developing coronary atherosclerosis. Microvascular structural abnormalities in the retinal circulation may predict macrovascular events such as stroke and coronary heart disease...
November 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27428252/consensus-genome-wide-expression-quantitative-trait-loci-and-their-relationship-with-human-complex-trait-disease
#4
Chen-Hsin Yu, Lipika R Pal, John Moult
Most of the risk loci identified from genome-wide association (GWA) studies do not provide direct information on the biological basis of a disease or on the underlying mechanisms. Recent expression quantitative trait locus (eQTL) association studies have provided information on genetic factors associated with gene expression variation. These eQTLs might contribute to phenotype diversity and disease susceptibility, but interpretation is handicapped by low reproducibility of the expression results. To address this issue, we have generated a set of consensus eQTLs by integrating publicly available data for specific human populations and cell types...
July 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27327646/investigating-the-causal-relationship-of-c-reactive-protein-with-32-complex-somatic-and-psychiatric-outcomes-a-large-scale-cross-consortium-mendelian-randomization-study
#5
Bram P Prins, Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E Stuart, Javier Guterriez Achury, Vanisha Mistry, Jonathan P Bradfield, Ana M Valdes, Jose Bras, Aleksey Shatunov, Chen Lu, Buhm Han, Soumya Raychaudhuri, Steve Bevan, Maureen D Mayes, Lam C Tsoi, Evangelos Evangelou, Rajan P Nair, Struan F A Grant, Constantin Polychronakos, Timothy R D Radstake, David A van Heel, Melanie L Dunstan, Nicholas W Wood, Ammar Al-Chalabi, Abbas Dehghan, Hakon Hakonarson, Hugh S Markus, James T Elder, Jo Knight, Dan E Arking, Timothy D Spector, Bobby P C Koeleman, Cornelia M van Duijn, Javier Martin, Andrew P Morris, Rinse K Weersma, Cisca Wijmenga, Patricia B Munroe, John R B Perry, Jennie G Pouget, Yalda Jamshidi, Harold Snieder, Behrooz Z Alizadeh
BACKGROUND: C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. METHODS AND FINDINGS: We performed Mendelian randomization (MR) analyses using two genetic risk scores (GRSs) as instrumental variables (IVs). The first GRS consisted of four single nucleotide polymorphisms (SNPs) in the CRP gene (GRSCRP), and the second consisted of 18 SNPs that were significantly associated with CRP levels in the largest genome-wide association study (GWAS) to date (GRSGWAS)...
June 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27144035/tirofiban-induced-thrombocytopenia-occurring-with-crohn-s-disease
#6
Toni Ibrahim, Fady El Karak, Assem Araji, Elie El Rassy
A 69-year-old man, with severe refractory Crohn's disease, presented with acute coronary syndrome that required angioplasty. He developed severe tirofiban-induced thrombocytopenia (TIT) heralded by type I allergic reaction that required steroids and a combination of antihistamine H1 and antihistamine H2 for symptomatic management. The thrombocytopenia spontaneously resolved uneventfully in 48 hours thereafter. This case report suggests a possible association between TIT and inflammatory bowel disease. Therefore, strict monitoring of the platelet count is required in patients who develop allergic reactions to tirofiban...
2016: Case Reports in Cardiology
https://www.readbyqxmd.com/read/27088787/-desaturases-of-fatty-acids-fads-and-their-physiological-and-clinical-implication
#7
Aleš Žák, Adolf Slabý, Eva Tvrzická, Marie Jáchymová, Jaroslav Macášek, Marek Vecka, Miroslav Zeman, Barbora Staňková
States associated with insulin resistance, as overweight/obesity, type 2 diabetes mellitus (DM2), cardiovascular diseases (CVD), some cancers and neuropsychiatric diseases are characterized with a decrease of long-chain polyunsaturated fatty acids (LC-PUFA) levels. Amounts of LC-PUFA depend on the exogenous intake of their precursors [linoleic (LA) and α-linolenic acid (ALA)] and by rate of their metabolism, which is influenced by activities of enzymes, such as Δ6-desaturase (D6D, FADS2), D5D, FADS1, elongases (Elovl2, -5, 6)...
2016: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/26919462/association-between-parkinson-s-disease-and-inflammatory-bowel-disease-a-nationwide-taiwanese-retrospective-cohort-study
#8
Jung-Chun Lin, Chin-Sheng Lin, Chin-Wang Hsu, Cheng-Li Lin, Chia-Hung Kao
OBJECTIVES: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder. Previous studies have suggested that chronic systemic inflammation increases the risk of Parkinson's disease (PD). This study examined the effects of IBD on the development of PD. METHODS: In a nationwide population-based cohort of 23.22 million insured residents of Taiwan aged ≥ 20 years, we compared people diagnosed with IBD during 2000 to 2011 (n = 8373) with IBD-free individuals...
May 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/26916514/binomial-mixture-model-based-association-testing-to-account-for-genetic-heterogeneity-for-gwas
#9
Zhiyuan Xu, Wei Pan
Genome-wide association studies (GWAS) have confirmed the ubiquitous existence of genetic heterogeneity for common disease: multiple common genetic variants have been identified to be associated, while many more are yet expected to be uncovered. However, the single SNP (single-nucleotide polymorphism) based trend test (or its variants) that has been dominantly used in GWAS is based on contrasting the allele frequency difference between the case and control groups, completely ignoring possible genetic heterogeneity...
April 2016: Genetic Epidemiology
https://www.readbyqxmd.com/read/26913459/aggregator-a-gene-based-gene-gene-interacttion-test-for-case-control-association-studies
#10
Mathieu Emily
Among the large of number of statistical methods that have been proposed to identify gene-gene interactions in case-control genome-wide association studies (GWAS), gene-based methods have recently grown in popularity as they confer advantage in both statistical power and biological interpretation. All of the gene-based methods jointly model the distribution of single nucleotide polymorphisms (SNPs) sets prior to the statistical test, leading to a limited power to detect sums of SNP-SNP signals. In this paper, we instead propose a gene-based method that first performs SNP-SNP interaction tests before aggregating the obtained p-values into a test at the gene level...
April 2016: Statistical Applications in Genetics and Molecular Biology
https://www.readbyqxmd.com/read/26517927/tribbles-1-a-novel-regulator-of-hepatic-lipid-metabolism-in-humans
#11
REVIEW
Robert C Bauer, Batuhan O Yenilmez, Daniel J Rader
The protein tribbles-1, encoded by the gene TRIB1, is increasingly recognized as a major regulator of multiple cellular and physiological processes in humans. Recent human genetic studies, as well as molecular biological approaches, have implicated this intriguing protein in the aetiology of multiple human diseases, including myeloid leukaemia, Crohn's disease, non-alcoholic fatty liver disease (NAFLD), dyslipidaemia and coronary artery disease (CAD). Genome-wide association studies (GWAS) have repeatedly identified variants at the genomic TRIB1 locus as being significantly associated with multiple plasma lipid traits and cardiovascular disease (CVD) in humans...
October 2015: Biochemical Society Transactions
https://www.readbyqxmd.com/read/26514677/association-between-long-term-lipid-profiles-and-disease-severity-in-a-large-cohort-of-patients-with-inflammatory-bowel-disease
#12
Efstratios Koutroumpakis, Claudia Ramos-Rivers, Miguel Regueiro, Jana G Hashash, Arthur Barrie, Jason Swoger, Leonard Baidoo, Marc Schwartz, Michael A Dunn, Ioannis E Koutroubakis, David G Binion
BACKGROUND: Inflammatory bowel disease (IBD) has been linked to an increased risk of coronary heart disease and stroke. Dyslipidemia is a well-established risk factor for cardiovascular disease. The aim of this study was to investigate the long-term lipid profiles in a large cohort of IBD patients. METHODS: Data of patients from an IBD registry who had more than one measurement of total cholesterol and triglyceride levels during the follow-up period were analyzed...
March 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26328098/ureterocutaneostomy-for-whom-and-when
#13
Zafer Kozacıoğlu, Tansu Değirmenci, Bülent Günlüsoy, Yasin Ceylan, Süleyman Minareci
OBJECTIVE: To discuss the indications and the results of the patients treated with ureterocutaneostomy (UCN) for urinary diversion in our center. MATERIAL AND METHODS: Between March 2008 and November 2012, 27 patients (19 males and 8 females) were treated with UCN in our clinic. Patients' ages ranged between 56-78 years. Radical cystectomy was performed on 21 of these patients. The patients underwent transureteroureterostomy and UCN or unilateral or bilateral side-by-side UCN on the abdominal wall...
September 2013: Turkish Journal of Urology
https://www.readbyqxmd.com/read/25972153/persistent-reactive-thrombocytosis-may-increase-the-risk-of-coronary-artery-disease-among-inflammatory-bowel-disease-patients
#14
COMPARATIVE STUDY
Sudeep Dhoj Thapa, Hiba Hadid, Waseem Imam, Ahmad Hassan, Muhammad Usman, Syed-Mohammed Jafri, Jason Schairer
BACKGROUND: IBD patients are at increased risk of coronary artery disease in the absence of traditional risk factors. However, the disease-related risk factors remain poorly understood although increased inflammation seems to increase cardiovascular disease risk in IBD. Thrombocytes are involved in the pathogenesis of coronary artery disease, and a subset of IBD patients have reactive thrombocytosis. AIM: The aim of our study was to investigate the effect of persistent reactive thrombocytosis on the development of coronary artery disease in IBD...
October 2015: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/25937569/genetic-basis-of-common-human-disease-insight-into-the-role-of-missense-snps-from-genome-wide-association-studies
#15
Lipika R Pal, John Moult
Recent genome-wide association studies (GWAS) have led to the reliable identification of single nucleotide polymorphisms (SNPs) at a number of loci associated with increased risk of specific common human diseases. Each such locus implicates multiple possible candidate SNPs for involvement in disease mechanism. A variety of mechanisms may link the presence of an SNP to altered in vivo gene product function and hence contribute to disease risk. Here, we report an analysis of the role of one of these mechanisms, missense SNPs (msSNPs) in proteins in seven complex trait diseases...
July 3, 2015: Journal of Molecular Biology
https://www.readbyqxmd.com/read/25699123/inflammatory-bowel-disease-as-a-risk-factor-for-premature-coronary-artery-disease
#16
Phillip Ruisi, John N Makaryus, Michael Ruisi, Amgad N Makaryus
BACKGROUND: Crohn's disease and ulcerative colitis are both systemic chronic diseases that alter bowel physiology. The central process in inflammatory bowel disease (IBD) and the associated manifestations are the result of B-cell production of IgG autoantibodies directed against self-antigens in various organ systems including coronary endothelium. Previous studies have demonstrated significant micro-vascular endothelial dysfunction in patients with IBD compared to patients not affected by the disease...
April 2015: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/25632180/hyperhomocysteinemia-as-a-potential-contributor-of-colorectal-cancer-development-in-inflammatory-bowel-diseases-a-review
#17
REVIEW
Ammar Hassanzadeh Keshteli, Vickie E Baracos, Karen L Madsen
Homocysteine is an amino acid generated metabolically by the S-adenosylmethionine-dependent transmethylation pathway. In addition to being a well-known independent risk factor for coronary heart disease, is also a risk factor for cancer. Patients suffering from inflammatory bowel diseases (IBD) including ulcerative colitis and Crohn's disease are at increased risk of developing colorectal cancer in comparison to healthy individuals. Furthermore, the risk of hyperhomocysteinaemia is significantly higher in IBD patients when compared with controls...
January 28, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25560640/phenome-genome-association-studies-of-pancreatic-cancer-new-targets-for-therapy-and-diagnosis
#18
Ramaswamy Narayanan
BACKGROUND: Pancreatic cancer, has a very high mortality rate and requires novel molecular targets for diagnosis and therapy. Genetic association studies over databases offer an attractive starting point for gene discovery. MATERIALS AND METHODS: The National Center for Biotechnology Information (NCBI) Phenome Genome Integrator (PheGenI) tool was enriched for pancreatic cancer-associated traits. The genes associated with the trait were characterized using diverse bioinformatics tools for Genome-Wide Association (GWA), transcriptome and proteome profile and protein classes for motif and domain...
January 2015: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/25446295/steroid-exposure-acute-coronary-syndrome-and-inflammatory-bowel-disease-insights-into-the-inflammatory-milieu
#19
Pearl Zakroysky, Wai-ee Thai, Roderick C Deaño, Sandeep Basnet, Zurine Galvan Onandia, Sachin Gandhi, Ahmed Tawakol, James K Min, Quynh A Truong
BACKGROUND: Steroids are anti-inflammatory agents commonly used to treat inflammatory bowel disease. Inflammation plays a critical role in the pathophysiology of both inflammatory bowel disease and acute coronary syndrome. We examined the relationship between steroid use in patients with inflammatory bowel disease and acute coronary syndrome. METHODS: In 177 patients with inflammatory bowel disease (mean age 67 years, 75% male, 44% Crohn's disease, 56% ulcerative colitis), we performed a 1:2 case-control study matched for age, sex, and inflammatory bowel disease type, and compared 59 patients with inflammatory bowel disease with acute coronary syndrome to 118 patients with inflammatory bowel disease without acute coronary syndrome...
March 2015: American Journal of Medicine
https://www.readbyqxmd.com/read/25128749/impaired-coronary-microvascular-and-left-ventricular-diastolic-function-in-patients-with-inflammatory-bowel-disease
#20
Zuhal Caliskan, Huseyin Savas Gokturk, Mustafa Caliskan, Hakan Gullu, Ozgur Ciftci, Gülsüm Teke Ozgur, Aytekin Guven, Haldun Selcuk
BACKGROUND AND AIM: Increased incidence of coronary vascular events in patients with inflammatory bowel disease (IBD) is known. However, the association between coronary microvascular function and IBD has not been fully defined. We aimed to investigate whether coronary flow reserve (CFR) and left ventricular diastolic function were impaired in IBD patients. METHODS: Seventy-two patients with IBD (36 patients with ulcerative colitis [UC] and 36 Crohn's disease [CD]) were registered...
January 2015: Microvascular Research
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