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https://www.readbyqxmd.com/read/29858679/extension-of-c-elegans-lifespan-using-the-%C3%A2-no-delivery-dinitrosyl-iron-complexes
#1
Hsiao-Wen Huang, Yen-Hung Lin, Min-Hsuan Lin, Ya-Rong Huang, Chih-Hung Chou, Hsiao-Chin Hong, Mei-Ren Wang, Yu-Ting Tseng, Po-Chun Liao, Min-Chuan Chung, Yu-Jie Ma, Shou-Cheng Wu, Yung-Jen Chuang, Horng-Dar Wang, Yun-Ming Wang, Hsien-Da Huang, Tsai-Te Lu, Wen-Feng Liaw
The ubiquitous and emerging physiology function of endogenous nitric oxide in vascular, myocardial, immune, and neuronal systems prompts chemists to develop a prodrug for the controlled delivery of ·NO in vivo and for the translational biomedical application. Inspired by the discovery of natural [Fe(NO)2 ] motif, herein, we develop the synthetic dinitrosyl iron complexes (DNICs) [Fe2 (μ-SR)2 (NO)4 ] (1) as a universal platform for the O2 -triggered release of ·NO, for the regulation of ·NO-release kinetics (half-life = 0...
June 1, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29790499/mass-spectrometric-detection-of-iron-nitrosyls-sulfide-oxidation-and-mycothiolation-during-nitrosylation-of-the-no-sensor-4fe-4s-nsrr
#2
Jason C Crack, Chris J Hamilton, Nick E Le Brun
The bacterial nitric oxide (NO)-sensing transcriptional regulator NsrR binds a [4Fe-4S] cluster that enables DNA-binding and thus repression of the cell's NO stress response. Upon exposure to NO, the cluster undergoes a complex nitrosylation reaction resulting in a mixture of iron-nitrosyl species, which spectroscopic studies have indicated are similar to well characterized low molecular weight dinitrosyl iron complex (DNIC), Roussin's Red Ester (RRE) and Roussin's Black Salt (RBS). Here we report mass spectrometric studies that enable the unambiguous identification of NsrR-bound RRE-type species, including a persulfide bound form that results from the oxidation of cluster sulfide...
May 23, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29756619/electrodeposited-film-electrodes-derived-from-a-precursor-dinitrosyl-iron-complex-for-electrocatalytic-water-splitting
#3
Wei-Liang Li, Tzung-Wen Chiou, Chien-Hong Chen, Yi-Ju Yu, Li-Kang Chu, Wen-Feng Liaw
In artificial photosynthesis, water splitting plays an important role for the conversion and storage of renewable energy sources. Here, we report a study on the electrocatalytic properties of the electrodeposited-film electrodes derived from irreversible electro-reduction/-oxidation of a molecular dinitrosyl iron complex (DNIC) {Fe(NO)2}9 [(Me6tren)Fe(NO)2]+ (Me6tren = tris[2-(dimethylamino)ethyl]amine) for the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER) in alkaline solution, individually...
May 14, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29752896/wavelength-dependence-of-vasodilation-and-no-release-from-s-nitrosothiols-and-dinitrosyl-iron-complexes-by-far-red-near-infrared-light
#4
Agnes Keszler, Brian Lindemer, Neil Hogg, Dorothee Weihrauch, Nicole L Lohr
Far red/near infrared (R/NIR) energy is a novel therapy, but its mechanism of action is poorly characterized. Cytochrome c oxidase (Cco) of the mitochondrial electron transport chain is considered the primary photoacceptor for R/NIR to photolyze a putative heme nitrosyl in Cco to liberate free nitric oxide (NO). We previously observed R/NIR light directly liberates NO from nitrosylated hemoglobin and myoglobin, and recently suggested S-nitrosothiols (RSNO) and dinitrosyl iron complexes (DNIC) may be primary sources of R/NIR-mediated NO...
May 9, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29733874/diffuse-noxious-inhibitory-controls-and-brain-networks-are-modulated-in-a-testosterone-dependent-manner-in-sprague-dawley-rats
#5
Joyce T Da Silva, Youping Zhang, Jamila Asgar, Jin Y Ro, David A Seminowicz
Diffuse noxious inhibitory control (DNIC), which involves endogenous pain modulation, has been investigated as a potential mechanism for the differences in pain modulation observed between men and women, though the literature shows contradictory findings. We used a capsaicin-induced DNIC behavioral assay and resting state functional magnetic resonance imaging (rsfMRI) to assess the effect of testosterone on pain modulation and related brain circuitry in rats. We hypothesized that testosterone is required for DNIC that leads to efficient pain inhibition by increasing descending pain modulation...
May 4, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29698982/a-fast-track-to-hypoalgesia-the-anaerobic-exercise-effect-on-pain-sensitivity
#6
Gil Samuelly-Leichtag, Einat Kodesh, Yoav Meckel, Irit Weissman-Fogel
Maximal anaerobic exercise, is a short high intensity effort, involves activation of the hypothalamus-pituitary-adrenal axis, and may suggest hypoalgesic effects. In addition, this exercise-induced muscle pain may contribute to hypoalgesia via the pain inhibits pain phenomenon, which is related to the diffuse noxious inhibitory control (DNIC) mechanism. We aimed to investigate whether: 1) a single bout of 30 s maximal anaerobic exercise has an analgesic effect on experimental pain sensitivity; 2) DNIC is the underlying mechanism of anaerobic exercise-induced hypoalgesia (EIH)...
June 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29681797/electroacupuncture-potentiates-cannabinoid-receptor-mediated-descending-inhibitory-control-in-a-mouse-model-of-knee-osteoarthritis
#7
Xiao-Cui Yuan, Bing Zhu, Xiang-Hong Jing, Li-Ze Xiong, Cai-Hua Wu, Fang Gao, Hong-Ping Li, Hong-Chun Xiang, He Zhu, Bin Zhou, Wei He, Chuan-You Lin, Hui-Lin Pan, Qiang Wang, Man Li
Knee osteoarthritis (KOA) is a highly prevalent, chronic joint disorder, which can lead to chronic pain. Although electroacupuncture (EA) is effective in relieving chronic pain in the clinic, the involved mechanisms remain unclear. Reduced diffuse noxius inhibitory controls (DNIC) function is associated with chronic pain and may be related to the action of endocannabinoids. In the present study, we determined whether EA may potentiate cannabinoid receptor-mediated descending inhibitory control and inhibit chronic pain in a mouse model of KOA...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29522907/nitric-oxide-reduces-oxidative-stress-in-cancer-cells-by-forming-dinitrosyliron-complexes
#8
Sumit Sahni, Jason R Hickok, Douglas D Thomas
The chelatable iron pool (CIP) is a small but chemically significant fraction of total cellular iron. While this dynamic population of iron is limited, it is redox active and capable of generating reactive oxygen species (ROS) that can lead to oxidative stress which is associated with various pathologies. Nitric oxide (•NO), is a free radical signalling molecule that regulates numerous physiological and pathological conditions. We have previously shown that macrophages exposed to endogenously generated or exogenously administered nitric oxide (•NO) results in its interaction with CIP to form dinitrosyliron complexes with thiol containing ligands (DNICs)...
June 1, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29469215/dinitrosyl-iron-complexes-formation-and-antiradical-action-in-heart-mitochondria
#9
Konstantin B Shumaev, Arina L Dudylina, Marina V Ivanova, Igor S Pugachenko, Enno K Ruuge
Mitochondria are widely known as a major source of reactive oxygen and nitrogen species for the cardiovascular system. Numerous studies established that superoxide anion radical production by heart mitochondria is only slightly suppressed under conditions of deep hypoxia, but is completely blocked under anoxia. It was found also that dinitrosyl iron complexes (DNIC) compare favourably with other physiologically active derivatives of nitric oxide (NO). DNIC with glutathione effectively scavenge superoxide radicals generated by mitochondria at different partial pressures of oxygen...
February 22, 2018: BioFactors
https://www.readbyqxmd.com/read/29464522/protective-effects-of-a-modified-apelin-12-and-dinitrosyl-iron-complexes-in-experimental-cardioplegic-ischemia-and-reperfusion
#10
Irina Studneva, Valentin Shulzhenko, Oksana Veselova, Oleg Pisarenko
The maintenance of nitric oxide (NO) bioavailability has been recognized as an important component of myocardial protection during cardiac surgery. This study was designed to evaluate the efficacy of using two NO-donating compounds in cardioplegia and reperfusion: (i) a modified peptide apelin-12 (MA12) that activates endothelial NO synthase (eNOS) and (ii) dinitrosyl iron complexes with reduced glutathione (DNIC-GS), a natural NO vehicle. Isolated perfused working rat hearts were subjected to normothermic global ischemia and reperfusion...
February 20, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29447711/no-355-physiologic-basis-of-pain-in-labour-and-delivery-an-evidence-based-approach-to-its-management
#11
Julie Bonapace, Guy-Paul Gagné, Nils Chaillet, Raymonde Gagnon, Emmanuelle Hébert, Sarah Buckley
OBJECTIVE: To review the evidence relating to nonpharmacological approaches in the management of pain during labour and delivery. To formulate recommendations for the usage of nonpharmacological approaches to pain management. OPTIONS: Nonpharmacological methods available for pain management during labour and delivery exist. These should be included in the counselling and care of women. EVIDENCE: PubMed and Medline were searched for articles in French and English on subjects related to "breastfeeding," "pain," "epidural," "anaesthesia," "analgesia," "labour," "labor," and combined with "gate control theory," "alternative therapies," "massage," "position," "mobility," "TENS," "bathing," "DNIC," "acupuncture," "acupressure," "sterile water injection," "higher center," "control mind," "cognitive structuring," "holistic health," "complementary therapy(ies)," "breathing," "relaxation," "mental imagery," "visualization," "mind focusing," "hypnosis," "auto-hypnosis," "sophrology," "mind and body interventions," "music," "odors," "biofeedback," "Lamaze," "Bonapace," "prenatal training," "gymnastic," "chanting," "haptonomy," "environment," "transcutaneous electrical stimulus-stimulation," "antenatal education," "support," "continuous support," "psychosocial support," "psychosomatic medicine," "supportive care," "companion," "intrapartum care," "nurse," "midwife(ves)," "father," "doula," "caregiver," " hormones," "oxytocin," "endorphin," "prolactin," "catecholamine," "adrenaline," and "noradrenaline" from 1990 to December 2015...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29373948/tbi-disrupts-pain-signaling-in-the-brainstem-and-spinal-cord
#12
Karen-Amanda Irvine, Peyman Sahbaie, De-Yong Liang, David Clark
Chronic pain is a common consequence of traumatic brain injury (TBI) that can increase a patient's suffering and pose a significant challenge to rehabilitative efforts. Unfortunately, the mechanisms linking TBI to pain are poorly understood and specific treatments for TBI-related pain are still lacking. Our lab has shown that TBI causes pain sensitization in areas distant to the site of primary injury, and that changes in spinal gene expression may underlie this sensitization1, 2. The aim of this study was to examine the roles that pain modulatory pathways descending from the brainstem play in pain after TBI...
January 26, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29369967/lateralized-kappa-opioid-receptor-signaling-from-the-amygdala-central-nucleus-promotes-stress-induced-functional-pain
#13
Kelsey M Nation, Milena De Felice, Pablo I Hernandez, David W Dodick, Volker Neugebauer, Edita Navratilova, Frank Porreca
The response of diffuse noxious inhibitory controls (DNIC) is often decreased, or lost, in stress-related functional pain syndromes. Because the dynorphin/kappa opioid receptor (KOR) pathway is activated by stress, we determined its role in DNIC using a model of stress-induced functional pain. Male, Sprague-Dawley rats were primed for 7 days with systemic morphine resulting in opioid-induced hyperalgesia. Fourteen days after priming, when hyperalgesia was resolved, rats were exposed to environmental stress and DNIC was evaluated by measuring hind paw response threshold to noxious pressure (test stimulus) after capsaicin injection in the forepaw (conditioning stimulus)...
May 2018: Pain
https://www.readbyqxmd.com/read/29315872/theoretical-investigations-on-the-mechanistic-aspects-of-o-2-activation-by-a-biomimetic-dinitrosyl-iron-complex
#14
Ambar Banerjee, Souloke Sen, Ankan Paul
Though dinitrosyl-iron complexes (DNICs) are largely believed to act as NO carriers, several experiments on model DNICs have suggested that they can also act as nitrating agents in presence of dioxygen. Oxygen activation by DNICs has been implicated as a possible route for protein tyrosine nitration (PTN), which leads to neurodegenerative disorders. Herein using static and dynamic theoretical techniques we unravel a previously unknown dual state mechanistic paradigm for dioxygen activation of a biomimetic nitrating DNIC complex leading to phenolic nitration...
March 2, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29304478/differential-mitochondrial-dinitrosyliron-complex-formation-by-nitrite-and-nitric-oxide
#15
Douglas D Thomas, Catherine Corey, Jason Hickok, Yinna Wang, Sruti Shiva
Nitrite represents an endocrine reserve of bioavailable nitric oxide (NO) that mediates a number of physiological responses including conferral of cytoprotection after ischemia/reperfusion (I/R). It has long been known that nitrite can react with non-heme iron to form dinitrosyliron complexes (DNIC). However, it remains unclear how quickly nitrite-dependent DNIC form in vivo, whether formation kinetics differ from that of NO-dependent DNIC, and whether DNIC play a role in the cytoprotective effects of nitrite...
May 2018: Redox Biology
https://www.readbyqxmd.com/read/29297116/the-inhibitory-effect-of-dinitrosyl-iron-complexes-no-donors-on-myeloperoxidase-activity
#16
N P Akentieva, N A Sanina, A R Gizatullin, N Y Shmatko, N S Goryachev, N I Shkondina, T R Prikhodchenko, S M Aldoshin
The effect of synthetic analogues of dinitrosyl mononuclear iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the activity of myeloperoxidase (MPO) was studied, and their efficiency was evaluated. It was shown that the enzyme MPO is the molecular target of DNICs. It was found that six DNICs inhibited the activity of MPO and one compound potentiated it. The evaluation of their efficiency showed that two DNICs effectively inhibited the activity of MPO by 50% at IC50 = 2 × 10-4 M and IC50 = 5 × 10-7 M...
November 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28636310/sensing-mechanisms-in-the-redox-regulated-2fe-2s-cluster-containing-bacterial-transcriptional-factor-soxr
#17
Kazuo Kobayashi
Bacteria possess molecular biosensors that enable responses to a variety of stressful conditions, including oxidative stress, toxic compounds, and interactions with other organisms, through elaborately coordinated regulation of gene expression. In Escherichia coli and related bacteria, the transcription factor SoxR functions as a sensor of oxidative stress and nitric oxide (NO). SoxR protein contains a [2Fe-2S] cluster essential for its transcription-enhancing activity, which is regulated by redox changes in the [2Fe-2S] cluster...
June 21, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28387936/the-plasticity-of-descending-controls-in-pain-translational-probing
#18
REVIEW
Kirsty Bannister, A H Dickenson
Descending controls, comprising pathways that originate in midbrain and brainstem regions and project onto the spinal cord, have long been recognised as key links in the multiple neural networks that interact to produce the overall pain experience. There is clear evidence from preclinical and clinical studies that both peripheral and central sensitisation play important roles in determining the level of pain perceived. Much emphasis has been put on spinal cord mechanisms in central excitability, but it is now becoming clear that spinal hyperexcitability can be regulated by descending pathways from the brain that originate from predominantly noradrenergic and serotonergic systems...
July 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28219722/regulation-and-control-of-nitric-oxide-no-in-macrophages-protecting-the-professional-killer-cell-from-its-own-cytotoxic-arsenal-via-mrp1-and-gstp1
#19
REVIEW
Z Kovacevic, S Sahni, H Lok, M J Davies, D A Wink, D R Richardson
We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug resistance protein 1 (MRP1/ABCC1), protects M1-macrophage (M1-MØ) models from large quantities of endogenous NO. This system stores and transports NO as dinitrosyl-dithiol-iron complexes (DNICs) composed of iron, NO and glutathione (GSH). Hence, this gas with contrasting anti- and pro-tumor effects, which has been assumed to be freely diffusible, is a tightly-regulated species in M1-MØs...
May 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28216238/dinitrosyl-iron-complexes-with-natural-thiol-containing-ligands-in-aqueous-solutions-synthesis-and-some-physico-chemical-characteristics-a-methodological-review
#20
REVIEW
Anatoly F Vanin, Rostislav R Borodulin, Vasak D Mikoyan
Two approaches to the synthesis of dinitrosyl iron complexes (DNIC) with glutathione and l-cysteine in aqueous solutions based on the use of gaseous NO and appropriate S-nitrosothiols, viz., S-nitrosoglutathione (GS-NO) or S-nitrosocysteine (Cys-NO), respectively, are considered. A schematic representation of a vacuum unit for generation and accumulation of gaseous NO purified from the NO2 admixture and its application for obtaining aqueous solutions of DNIC in a Thunberg apparatus is given. To achieve this, a solution of bivalent iron in distilled water is loaded into the upper chamber of the Thunberg apparatus, while the thiol solution in an appropriate buffer (рН 7...
June 1, 2017: Nitric Oxide: Biology and Chemistry
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