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https://www.readbyqxmd.com/read/29228649/combination-of-dual-serum-fluorescence-afp-and-hepatic-function-tests-is-valuable-to-identify-hcc-in-afp-elevated-liver-diseases
#1
Ting Wang, Kun-He Zhang, Piao-Ping Hu, Qin-Si Wan, Fang-Li Han, Jian-Ming Zhou, De-Qiang Huang, Nong-Hua Lv
Serum alpha-fetoprotein (AFP) levels elevated in benign liver diseases (BLD) represent a challenge in hepatocellular carcinoma (HCC) diagnosis. The present study aimed to develop a simple method to identify HCC in AFP-elevated liver diseases based on combining serum fluorescence and general clinical data. Serum specimens and clinical data were collected from 201 HCC and 117 BLD (41 liver cirrhosis, 76 chronic hepatitis) patients with abnormal serum AFP levels. Dual serum fluorescence (autofluorescence and cell-free DNA-related fluorescence) intensities were sequentially measured and expressed as 6 fluorescence indicators...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29126320/screening-lactic-acid-bacteria-to-manufacture-two-stage-fermented-feed-and-pelleting-to-investigate-the-feeding-effect-on-broilers
#2
Ruei Han Yeh, Chia Wen Hsieh, Kuo Lung Chen
Bacillus subtilis var. natto N21 (BS) and different lactic acid bacteria were applied to produce two-stage fermented feeds. Broilers were fed these feeds to select the best fermented feed. The selected fermented feed was pelleted and investigated for its effects on growth performance, carcass traits, intestinal microflora, serum biochemical constituents, and apparent ileal nutrient digestibility. Trial 1 involved three hundred thirty-six 1-d-old broilers with equal numbers of each sex, randomly assigned into control, BS + Bacillus coagulans L12 (BBC), BS + Lactobacillus casei (BLC), BS + Lactobacillus acidophilus (BLA), BS + Lactobacillus acidophilus L15 (BLA15), BS + Lactobacillus delbruekckii (BLD), and BS + Lactobacillus reuteri P24 (BLR24) groups with 3 replicates per group...
November 4, 2017: Poultry Science
https://www.readbyqxmd.com/read/29102831/bilateral-deficit-in-explosive-force-related-to-sit-to-stand-performance-in-older-postmenopausal-women
#3
J D Ruiz-Cárdenas, J J Rodríguez-Juan, J M Jakobi, J Ríos-Díaz, E Marín-Cascales, J A Rubio-Arias
The purpose of this study was to determine whether the bilateral deficit (BLD) for maximal voluntary force (MVF) and rate of force development (RFD) influences sit-to-stand in older postmenopausal women. Fourteen women performed unilateral and bilateral maximal voluntary contractions during isometric leg-extension. The MVF and RFD over consecutive 50ms periods (0-50, 50-100 and 100-150ms) after force onset and the time to sit-to-stand test were calculated. There was only a BLD for RFD 0-50ms and 50-100ms. The time of sit-to-stand was moderately correlated to BLD for RFD 0-50ms (r=0...
October 31, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28912792/genotypic-variation-in-yield-yield-components-root-morphology-and-architecture-in-soybean-in-relation-to-water-and-phosphorus-supply
#4
Jin He, Yi Jin, Yan-Lei Du, Tao Wang, Neil C Turner, Ru-Ping Yang, Kadambot H M Siddique, Feng-Min Li
Water shortage and low phosphorus (P) availability limit yields in soybean. Roots play important roles in water-limited and P-deficient environment, but the underlying mechanisms are largely unknown. In this study we determined the responses of four soybean [Glycine max (L.) Merr.] genotypes [Huandsedadou (HD), Bailudou (BLD), Jindou 21 (J21), and Zhonghuang 30 (ZH)] to three P levels [applied 0 (P0), 60 (P60), and 120 (P120) mg P kg(-1) dry soil to the upper 0.4 m of the soil profile] and two water treatment [well-watered (WW) and water-stressed (WS)] with special reference to root morphology and architecture, we compared yield and its components, root morphology and root architecture to find out which variety and/or what kind of root architecture had high grain yield under P and drought stress...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28898840/enhancement-of-solvent-production-by-overexpressing-key-genes-of-the-acetone-butanol-ethanol-fermentation-pathway-in-clostridium-saccharoperbutylacetonicum-n1-4
#5
Shaohua Wang, Sheng Dong, Yi Wang
Clostridium saccharoperbutylacetonicum N1-4 is well known as a hyper-butanol producing strain. However, little information is available concerning its butanol production mechanism and the development of more robust strains. In this study, key biosynthetic genes (either endogenous or exogenous) including the sol operon (bld-ctfA-ctfB-adc), adhE1, adhE1(D485G), thl, thlA1(V5A), thlA(V5A) and the expression cassette EC (thl-hbd-crt-bcd) were overexpressed in C. saccharoperbutylacetonicum N1-4 to evaluate their potential in enhancement of butanol production...
December 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28874787/blue-laser-diode-based-free-space-optical-data-transmission-elevated-to-18%C3%A2-gbps-over-16%C3%A2-m
#6
Yu-Fang Huang, Yu-Chieh Chi, Hsuan-Yun Kao, Chen-Ting Tsai, Huai-Yung Wang, Hao-Chung Kuo, Shuji Nakamura, Ding-Wei Huang, Gong-Ru Lin
Up to 18-Gbps direct encoding of blue laser diode (BLD) is demonstrated for free-space data transmission. By reshaping the orthogonal frequency multiplexed (16-QAM OFDM) stream with sidelobe filtering, the raw data rate expedites from 17.2 to 18.4 Gbps. Employing an ultrafast p-i-n photodiode with smaller active area diameter and lower noise equivalent power significantly enlarges the data rate by 1.6 Gbps or upgrades the signal-to-noise ratio (SNR) by 0.2 dB. Replacing the 80-mW BLD with the 120-mW one essentially increases the received SNR by 0...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28856933/serum-long-noncoding-rna-urothelial-carcinoma-associated-1-a-novel-biomarker-for-diagnosis-and-prognosis-of-hepatocellular-carcinoma
#7
Zhi-Kun Zheng, Cui Pang, Yang Yang, Qiong Duan, Ju Zhang, Wen-Chao Liu
Objective Long noncoding RNAs (lncRNAs) offer great potential as cancer biomarkers. This study was performed to assess the applicability of serum lncRNA urothelial carcinoma-associated 1 (UCA1) as a diagnostic and/or prognostic biomarker for hepatocellular carcinoma (HCC). Methods We examined UCA1 expression in serum samples from 105 patients with HCC, 105 patients with benign liver disease (BLD), and 105 healthy volunteers using reverse-transcription polymerase chain reaction and analyzed the relationship between serum UCA1 and clinicopathological parameters of HCC as well as survival...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28854333/combining-crispr-and-crispri-systems-for-metabolic-engineering-of-e-%C3%A2-coli-and-1-4-bdo-biosynthesis
#8
Meng-Ying Wu, Li-Yu Sung, Hung Li, Chun-Hung Huang, Yu-Chen Hu
Biosynthesis of 1,4-butanediol (1,4-BDO) in E. coli requires an artificial pathway that involves six genes and time-consuming, iterative genome engineering. CRISPR is an effective gene editing tool, while CRISPR interference (CRISPRi) is repurposed for programmable gene suppression. This study aimed to combine both CRISPR and CRISPRi for metabolic engineering of E. coli and 1,4-BDO production. We first exploited CRISPR to perform point mutation of gltA, replacement of native lpdA with heterologous lpdA, knockout of sad and knock-in of two large (6...
September 12, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28605645/novel-in-vivo-experimental-viability-assays-with-high-sensitivity-and-throughput-capacity-using-a-bdelloid-rotifer
#9
Zita Olah, Ashley I Bush, David Aleksza, Bence Galik, Eszter Ivitz, Lilla Macsai, Zoltan Janka, Zoltan Karman, Janos Kalman, Zsolt Datki
Rotifers have been used in biological research as well-characterized models of aging. Their multi-organ characters and their sensitivity for chemicals and environmental changes make them useful as in vivo toxicological and lifespan models. Our aim was to create a bdelloid rotifer model to use in high-throughput viability and non-invasive assays. In order to identify our species Philodina acuticornis odiosa (PA), 18S rDNA-based phylogenetic analysis was carried out and their species-specific morphological markers identified...
June 9, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28550991/production-of-1-3-diols-in-escherichia-coli
#10
Naoya Kataoka, Alisa S Vangnai, Thunyarat Pongtharangkul, Toshiharu Yakushi, Kazunobu Matsushita
To expand the diversity of chemical compounds produced through microbial conversion, a platform pathway for the production of widely used industrial chemicals, 1,3-diols, was engineered in Escherichia coli. The pathway was designed by modifying the previously reported (R)-1,3-butanediol synthetic pathway to consist of pct (propionate CoA-transferase) from Megasphaera elsdenii, bktB (thiolase), phaB (NADPH-dependent acetoacetyl-CoA reductase) from Ralstonia eutropha, bld (butyraldehyde dehydrogenase) from Clostridium saccharoperbutylacetonicum, and the endogenous alcohol dehydrogenase(s) of E...
May 18, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28528473/properties-of-streptomyces-albus-j1074-mutant-deficient-in-trna-leu-uaa-gene-blda
#11
Oksana Koshla, Maria Lopatniuk, Ihor Rokytskyy, Oleksandr Yushchuk, Yuriy Dacyuk, Victor Fedorenko, Andriy Luzhetskyy, Bohdan Ostash
Streptomyces albus J1074 is one of the most popular and convenient hosts for heterologous expression of gene clusters directing the biosynthesis of various natural metabolic products, such as antibiotics. This fuels interest in elucidation of genetic mechanisms that may limit secondary metabolism in J1074. Here, we report the generation and initial study of J1074 mutant, deficient in gene bldA for tRNA(Leu)UAA, the only tRNA capable of decoding rare leucyl TTA codon in Streptomyces. The bldA deletion in J1074 resulted in a highly conditional Bld phenotype, with depleted formation of aerial hyphae on certain solid media...
May 20, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28476699/analysis-and-detection-of-microporosities-in-aging-bones-in-context-to-pharmaceutical-treatment-a-study-in-line-of-osteoporosis
#12
Nadeem Baig, Muhammad Zaheer Khan
The objective of the current study was to evaluate the effects of nandrolone decanoate in terms of morphological changes in the diaphyseal region of appendicular skeleton long bone (femur) of aging female Albino rats with the help of innovatively designed histomorphometric tool of study being introduced first time mapped out micro porosities (lacunae) which tend to intensify as part of advanced aging denoting deterioration in osseous tissue. In fact our research trial has been in the line of involutional osteoporosis especially common in post-menopausal aged women, as to find out appropriate drug usefulness in the care and cure of this diseased state as per recommendation of FDA...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28318793/fate-and-mass-balance-of-bisphenol-analogues-in-wastewater-treatment-plants-in-xiamen-city-china
#13
Qian Sun, Yuwen Wang, Yan Li, Muhammad Ashfaq, Lanhua Dai, Xiaoqing Xie, Chang-Ping Yu
Due to the well-known endocrine disrupting ability of bisphenol A (BPA), its production and usage have been regulated. Consequently, other bisphenol analogues (BPs) have been used as the replacement of BPA. Despite their widespread use, few studies have investigated the occurrence and fate of BPs in wastewater treatment plants (WWTPs). In this study, we conducted a city-wide monitoring survey and collected the wastewater and sludge samples from seven WWTPs in Xiamen, China over seven days. The concentrations of dissolved and adsorbed BPs in the influent and effluent, together with the BP concentrations in the sludge were determined...
June 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28293229/fungal-root-microbiome-from-healthy-and-brittle-leaf-diseased-date-palm-trees-phoenix-dactylifera-l-reveals-a-hidden-untapped-arsenal-of-antibacterial-and-broad-spectrum-antifungal-secondary-metabolites
#14
Fedia B Mefteh, Amal Daoud, Ali Chenari Bouket, Faizah N Alenezi, Lenka Luptakova, Mostafa E Rateb, Adel Kadri, Neji Gharsallah, Lassaad Belbahri
In this study, we aimed to explore and compare the composition, metabolic diversity and antimicrobial potential of endophytic fungi colonizing internal tissues of healthy and brittle leaf diseased (BLD) date palm trees (Phoenix dactylifera L.) widely cultivated in arid zones of Tunisia. A total of 52 endophytic fungi were isolated from healthy and BLD roots of date palm trees, identified based on internal transcribed spacer-rDNA sequence analysis and shown to represent 13 species belonging to five genera. About 36...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28167420/the-influence-of-passenger-car-front-shape-on-pedestrian-injury-risk-observed-from-german-in-depth-accident-data
#15
Guibing Li, Mathew Lyons, Bingyu Wang, Jikuang Yang, Dietmar Otte, Ciaran Simms
Quantified relationships between passenger car front shape and pedestrian injury risk derived from accident data are sparse, especially considering the significant recent changes in car front design. The purpose of this paper is therefore to investigate the detailed effects of passenger car front shape on injury risk to a pedestrian's head, thorax, pelvis and leg in the event of a vehicle pedestrian impact. Firstly, an accident sample of 594 pedestrian cases captured during 2000-2015 from the German In-Depth Accident Study (GIDAS) database was employed...
April 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28152499/contributions-of-polyunsaturated-fatty-acids-pufa-on-cerebral-neurobiology-an-integrated-omics-approach-with-epigenomic-focus
#16
Nabarun Chakraborty, Seid Muhie, Raina Kumar, Aarti Gautam, Seshamalini Srinivasan, Bintu Sowe, George Dimitrov, Stacy-Ann Miller, Marti Jett, Rasha Hammamieh
The epigenetic landscape is vulnerable to diets. Here, we investigated the influence of different polyunsaturated fatty acids (PUFA) dietary supplements on rodents' nervous system development and functions and potential consequences to neurodegenerative disorders. Our previous nutrigenomics study showed significant impact of high n-3 PUFA-enriched diet (ERD) on synaptogenesis and various neuromodulators. The present study introduced a second equicaloric diet with n-6 PUFA balanced by n-3 PUFA (BLD). The typical lab diet with high n-6 PUFA was the baseline...
January 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28047251/tu-h-campus-jep2-02-interobserver-variability-of-ct-pet-ct-and-mri-based-primary-tumor-delineation-for-lung-cancer
#17
K Karki, G Hugo, S Saraiya, N Jan, J Schuster, M Schutzer, L Fahrner, R Groves, J Ford, E Weiss
PURPOSE: Target delineation in lung cancer radiotherapy has, in general, large variability. MRI has so far not been investigated in detail for lung cancer delineation variability. The purpose of this study is to investigate delineation variability for lung tumors using MRI and compare it to CT alone and PET-CT based delineations. METHODS: Seven physicians delineated the primary tumor volumes of nine patients for the following scenarios: (1) CT only; (2) post-contrast T1-weighted MRI registered with diffusion-weighted MRI; and (3) PET-CT fusion images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27816968/diagnostic-and-prognostic-value-of-serum-periostin-in-patients-with-non-small-cell-lung-cancer
#18
Chun-Hua Xu, Wei Wang, Yong Lin, Li-Hua Qian, Xiu-Wei Zhang, Qing-Bo Wang, Li-Ke Yu
The periostin protein is expressed in a variety of human malignancies. The aim of this study was to explore the diagnostic and prognostic value of serum periostin levels in patients with non-small cell lung cancer (NSCLC). We measured serum periostin levels by ELISA in 296 NSCLC patients, 120 benign lung diseases (BLD) patients and 160 healthy controls. The levels of serum periostin in NSCLC patients were significantly elevated compared with those in healthy controls (P < 0.001) and BLD patients (P < 0...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/27721249/serum-carcinoembryonic-antigen-neuron-specific-enolase-as-biomarkers-for-diagnosis-of-nonsmall-cell-lung-cancer
#19
Yanjun Dong, Xianjie Zheng, Zhongxin Yang, Mingfei Sun, Guoyu Zhang, Xiaokang An, Lihong Pan, Shuanglin Zhang
OBJECTIVE: To investigate the clinical efficacy of serum carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) as biomarkers for diagnosis of nonsmall cell lung cancer (NSCLC). MATERIAL AND METHODS: Forty-six cytology or pathology confirmed nonsmall cell lung patients and 33 cases of benign lung disease (BLD) were retrospective reviewed in our hospital from February 2013 to January 2016. The serum concentrations of CEA and NSE were measured by chemiluminescent assay...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27685634/activation-of-necroptosis-in-human-and-experimental-cholestasis
#20
Marta B Afonso, Pedro M Rodrigues, André L Simão, Dimitry Ofengeim, Tânia Carvalho, Joana D Amaral, Maria M Gaspar, Helena Cortez-Pinto, Rui E Castro, Junying Yuan, Cecília M P Rodrigues
Cholestasis encompasses liver injury and inflammation. Necroptosis, a necrotic cell death pathway regulated by receptor-interacting protein (RIP) 3, may mediate cell death and inflammation in the liver. We aimed to investigate the role of necroptosis in mediating deleterious processes associated with cholestatic liver disease. Hallmarks of necroptosis were evaluated in liver biopsies of primary biliary cholangitis (PBC) patients and in wild-type and RIP3-deficient (RIP3(-/-)) mice subjected to common bile duct ligation (BDL)...
September 29, 2016: Cell Death & Disease
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