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K Karki, G Hugo, S Saraiya, N Jan, J Schuster, M Schutzer, L Fahrner, R Groves, J Ford, E Weiss
PURPOSE: Target delineation in lung cancer radiotherapy has, in general, large variability. MRI has so far not been investigated in detail for lung cancer delineation variability. The purpose of this study is to investigate delineation variability for lung tumors using MRI and compare it to CT alone and PET-CT based delineations. METHODS: Seven physicians delineated the primary tumor volumes of nine patients for the following scenarios: (1) CT only; (2) post-contrast T1-weighted MRI registered with diffusion-weighted MRI; and (3) PET-CT fusion images...
June 2016: Medical Physics
Chun-Hua Xu, Wei Wang, Yong Lin, Li-Hua Qian, Xiu-Wei Zhang, Qing-Bo Wang, Li-Ke Yu
The periostin protein is expressed in a variety of human malignancies. The aim of this study was to explore the diagnostic and prognostic value of serum periostin levels in patients with non-small cell lung cancer (NSCLC). We measured serum periostin levels by ELISA in 296 NSCLC patients, 120 benign lung diseases (BLD) patients and 160 healthy controls. The levels of serum periostin in NSCLC patients were significantly elevated compared with those in healthy controls (P < 0.001) and BLD patients (P < 0...
November 1, 2016: Oncotarget
Yanjun Dong, Xianjie Zheng, Zhongxin Yang, Mingfei Sun, Guoyu Zhang, Xiaokang An, Lihong Pan, Shuanglin Zhang
OBJECTIVE: To investigate the clinical efficacy of serum carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) as biomarkers for diagnosis of nonsmall cell lung cancer (NSCLC). MATERIAL AND METHODS: Forty-six cytology or pathology confirmed nonsmall cell lung patients and 33 cases of benign lung disease (BLD) were retrospective reviewed in our hospital from February 2013 to January 2016. The serum concentrations of CEA and NSE were measured by chemiluminescent assay...
October 2016: Journal of Cancer Research and Therapeutics
Marta B Afonso, Pedro M Rodrigues, André L Simão, Dimitry Ofengeim, Tânia Carvalho, Joana D Amaral, Maria M Gaspar, Helena Cortez-Pinto, Rui E Castro, Junying Yuan, Cecília M P Rodrigues
Cholestasis encompasses liver injury and inflammation. Necroptosis, a necrotic cell death pathway regulated by receptor-interacting protein (RIP) 3, may mediate cell death and inflammation in the liver. We aimed to investigate the role of necroptosis in mediating deleterious processes associated with cholestatic liver disease. Hallmarks of necroptosis were evaluated in liver biopsies of primary biliary cholangitis (PBC) patients and in wild-type and RIP3-deficient (RIP3(-/-)) mice subjected to common bile duct ligation (BDL)...
September 29, 2016: Cell Death & Disease
Mathieu Nsenga Kumwimba, Bo Zhu, Tao Wang, Diana Kavidia Muyembe
Ditches are subjected to a large input of nutrients, trace metals, and arsenic and the enhancement of sedimentation due to human activities. However, the influence of different types of land uses on the distribution and associated environmental risk of metals and arsenic in the Red purple Sichuan Basin remains largely unclear, which is needed for water management. This study was carried out to characterize metal/metalloid status in ditch sediments from different land uses. A total of 68 surface sediment samples (0-5 cm) were collected from open ditches distributed in different land use types, i...
September 23, 2016: Environmental Science and Pollution Research International
Jakob Škarabot, Ruben Perellón Alfonso, Neil Cronin, Jure Bon, Vojko Strojnik, Janne Avela
PURPOSE: Interhemispheric inhibition may play a role in the expression of bilateral deficit in force (BLD). This study investigated whether the degree of BLD is reflected in the nature of interhemispheric interaction during unilateral and bilateral contractions. METHODS: Subjects divided into three groups, 'bilateral' (n = 7), 'unilateral' (n = 5) and 'control' (n = 8), performed unilateral and bilateral maximal voluntary isometric knee extensions while receiving electrical stimulation, and transcranial magnetic stimulation of the target and ipsilateral muscles...
December 2016: European Journal of Applied Physiology
Zheng Duan, Junzhi Liu, Ye Tuo, Gabriele Chiogna, Markus Disse
This study provides a comprehensive evaluation of eight high spatial resolution gridded precipitation products in Adige Basin located in Italy within 45-47.1°N. The Adige Basin is characterized by a complex topography, and independent ground data are available from a network of 101 rain gauges during 2000-2010. The eight products include the Version 7 TRMM (Tropical Rainfall Measuring Mission) Multi-satellite Precipitation Analysis 3B42 product, three products from CMORPH (the Climate Prediction Center MORPHing technique), i...
December 15, 2016: Science of the Total Environment
Xiao Wang, Jinghua Gu, Leena Hilakivi-Clarke, Robert Clarke, Jianhua Xuan
MOTIVATION: The advent of high-throughput DNA methylation profiling techniques has enabled the possibility of accurate identification of differentially methylated genes for cancer research. The large number of measured loci facilitates whole genome methylation study, yet posing great challenges for differential methylation detection due to the high variability in tumor samples. RESULTS: We have developed a novel probabilistic approach, DM-BLD, to detect differentially methylated genes based on a Bayesian framework...
September 11, 2016: Bioinformatics
Wenmin Xing, Lili Gu, Xinyue Zhang, Jiadong Xu, Hong Lu
Acyclovir (ACV) exposure is a common cause of acute kidney injury (AKI). The toxicity mechanism of ACV has always been a matter of debate. The present study investigated into the time-effect relationship and dose-effect relationship of ACV-induced nephrotoxicity in rats using metabonomics. Twenty-four rats were randomly divided into four groups: a 0.9% NaCl solution group, and 100, 300, and 600mg/kg ACV-treated groups; the ACV or vehicle solution was administered with a single intravenous injection. Urine was collected at different time periods (12h before administration, and 0-6h, 7-12h, and 13-24h after administration)...
September 2016: Environmental Toxicology and Pharmacology
A Romero-Rodríguez, B Ruiz-Villafán, V H Tierrafría, R Rodríguez-Sanoja, S Sánchez
In the genus Streptomyces, carbon utilization is of significant importance for the expression of genes involved in morphological differentiation and antibiotic production. However, there is little information about the mechanism involved in these effects. In the present work, it was found that glucose exerted a suppressive effect on the Streptomyces coelicolor actinorhodin (Act) and undecylprodigiosin (Red) production, as well as in its morphological differentiation. Accordingly, using a high-density microarray approach in S...
November 2016: Applied Biochemistry and Biotechnology
Hyun-Kyung Jung, Soyoun Kim, Rang-Woon Park, Jae-Yong Park, In-San Kim, Byungheon Lee
The overall prognosis of conventional chemotherapy for the treatment of bladder cancer is poor and reduction of its systemic side effects remains an unsolved issue. Targeted therapy for bladder cancer could improve therapeutic efficacy and reduce side effects. This study investigated a hybrid peptide (named Bld-1-KLA) composed of the CSNRDARRC peptide (Bld-1), which binds to bladder tumor cells, and the d-KLAKLAKKLAKLAK (KLA) peptide, which disrupts mitochondrial membrane and induces apoptotic cell death, as a bladder cancer-targeted therapeutic agent...
August 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Chun Hua Xu, Wei Wang, Yu Chao Wang, Yong Lin, Xiu Wei Zhang
INTRODUCTION: B7-H4, a member of the inhibitory B7 family, can restrain T cell proliferation, activation, cytokine secretion, and may be involved in immune evasion in cancer patients. OBJECTIVES: This aim of the study was to determine the expression level of soluble B7-H4 (sB7-H4) in circulation and to subsequently evaluate the clinical significance of circulating sB7-H4 in patients with non-small cell lung cancer (NSCLC). METHODS: Serum specimens from 128 patients with NSCLC, 100 healthy volunteers (HV), and 80 patients with benign lung diseases (BLD) were collected...
May 23, 2016: Clinical Respiratory Journal
José E Cetz-Chel, Edgar Balcázar-López, Edgardo U Esquivel-Naranjo, Alfredo Herrera-Estrella
BACKGROUND: Most living organisms use sunlight as a source of energy and/or information about their environment. Consequently, they have developed mechanisms to sense light quality and quantity. In the fungus Trichoderma atroviride blue-light is perceived through the Blue Light Regulator Complex, which in turn up-regulates a set of genes (blu) and down-regulates another set (bld), triggering asexual reproduction. To gain insight into this process, we characterized the blu7 gene, which encodes a protein containing a C2H2 zinc finger domain...
2016: BMC Genomics
Oliver Gonzalo-Skok, Julio Tous-Fajardo, Luis Suarez-Arrones, José Luis Arjol-Serrano, José Antonio Casajús, Alberto Mendez-Villanueva
PURPOSE: The aim of the present study was to compare the effects of unilateral and bilateral resistance training on single-leg power output, between-limb imbalance (BLI), bilateral deficit (BLD), change of direction (COD), linear sprinting and jumping performance in young elite basketball players. METHODS: Twenty-two young (U-16 to U-19) male basketball players were randomly assigned either to exclusive unilateral (UNI) (n=11) or bilateral (BIL) (n=11) resistance training group during a 6-week period...
May 3, 2016: International Journal of Sports Physiology and Performance
Haewon Byeon
OBJECTIVE: Studies on alcohol consumption and benign laryngeal disease (BLD) in the general population are rare. The aim of this study was to investigate the relationship between alcohol consumption and BLD in the Korean general population. STUDY DESIGN: This was a cross-sectional study of a national health survey. MATERIALS AND METHODS: Subjects were 3141 noninstitutionalized civilian adults older than 19 years (1313 men and 1828 women) who completed the laryngeal examination of the Korea National Health and Nutrition Examination Survey of 2008...
July 2016: Journal of Voice: Official Journal of the Voice Foundation
L Yang, Q Xu, H Xie, G Gu, J Jiang
BACKGROUND: Several recent studies have revealed that microRNAs (miRNAs) are stably detectable in the circulation and can be used as biomarkers for diagnosis and prognosis of malignancy. The aim of this manuscript is to investigate serum miR-218 expression in patients with hepatocellular carcinoma (HCC) and to analyze its potential diagnostic and prognostic value in HCC. METHODS: Quantitative real-time quantitative PCR (qPCR) was conducted to detect serum miR-218 expression from 156 HCC and 98 benign liver diseases (BLD) as well as 64 healthy controls...
August 2016: Clinical & Translational Oncology
Wen-Xiong Song, Shi-Jin Zhao, Gang Wang
The local structural inhomogeneity of glasses, as evidenced from broad bond-length distributions (BLDs), has been widely observed. However, the relationship between this particular structural feature and metastable states of glassy solids is poorly understood. It is important to understand the main problems of glassy solids, such as the plastic deformation mechanisms and glass-forming ability. The former is related to β-relaxation, the relaxation of a system from a subbasin to another in the potential energy landscape (PEL)...
September 21, 2015: Journal of Chemical Physics
Anastasia-Varvara Ferlemi, Penelope G Mermigki, Olga E Makri, Dimitrios Anagnostopoulos, Nikolaos S Koulakiotis, Marigoula Margarity, Anthony Tsarbopoulos, Constantinos D Georgakopoulos, Fotini N Lamari
Our goal was to delineate the mechanisms of selenite-induced oxidative stress in neonatal rats and investigate the potential of blueberry leaf polyphenols to counteract the induced stress. Vaccinium corymbosum leaf decoction (BLD) was analyzed by UPLC-MS and LC-DAD, along with its in vitro antioxidant activity (DPPH radical scavenging, FRAP, ferrous chelation). Newborn suckling Wistar rats were randomly divided into three groups: 'Se' and 'SeBLD' received 20 μmol Na2SeO3/kg BW subcutaneously (PN day 10); 'SeBLD' received 100 mg dry BLD/kg BW intraperitoneally (PN11 and 12) and Group 'C' received normal saline...
November 2015: Neurochemical Research
Hiromichi Yamane, Nobuaki Ochi, Tomoko Yamagishi, Yoshihiro Honda, Masami Takeyama, Nagio Takigawa
INTRODUCTION: Serum Krebs von den Lungen-6 (KL-6) level is an established diagnostic marker of interstitial lung disease (ILD). However, it is also elevated in patients with non-small cell lung cancer (NSCLC). The significance of circulating thymus and activation-regulated chemokine (TARC)/CC chemokine ligand 17 (CCL17) in malignant diseases remains unknown. METHODS: We measured circulating TARC/CCL17 and KL-6 using enzyme-linked immunosorbent assay and electrochemiluminescence immunoassay, respectively, in 26 patients with malignant disease and six patients with benign lung disease (BLD)...
2015: Therapeutics and Clinical Risk Management
Sean P Deats, Widya Adidharma, Lily Yan
Light has profound effects on mood regulation as exemplified in seasonal affective disorder (SAD) and the therapeutic benefits of light therapy. However, the underlying neural pathways through which light regulates mood are not well understood. Our previous work has developed the diurnal grass rat, Arvicanthis niloticus, as an animal model of SAD. Following housing conditions of either 12:12 h dim light:dark (DLD) or 8:16 h short photoperiod (SP), which mimic the lower light intensity or short day-length of winter, respectively, grass rats exhibit an increase in depression-like behavior compared to those housed in a 12:12 h bright light:dark (BLD) condition...
August 18, 2015: Neuroscience Letters
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