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https://www.readbyqxmd.com/read/29341850/clinical-inertia-in-a-randomized-trial-of-telemedicine-based-chronic-disease-management-lessons-learned
#1
Anna Beth Barton, Daniel E Okorodudu, Hayden B Bosworth, Matthew J Crowley
BACKGROUND: Treatment nonadherence and clinical inertia perpetuate poor cardiovascular disease (CVD) risk factor control. Telemedicine interventions may counter both treatment nonadherence and clinical inertia. INTRODUCTION: We explored why a telemedicine intervention designed to reduce treatment nonadherence and clinical inertia did not improve CVD risk factor control, despite enhancing treatment adherence versus usual care. METHODS: In this analysis of a randomized trial, we studied recipients of the 12-month telemedicine intervention...
January 17, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29341714/kinetically-controlled-two-step-amorphization-and-amorphous-amorphous-transition-in-ice
#2
Chuanlong Lin, Xue Yong, John S Tse, Jesse S Smith, Stanislav V Sinogeikin, Curtis Kenney-Benson, Guoyin Shen
We report the results of in situ structural characterization of the amorphization of crystalline ice Ih under compression and the relaxation of high-density amorphous (HDA) ice under decompression at temperatures between 96 and 160 K by synchrotron x-ray diffraction. The results show that ice Ih transforms to an intermediate crystalline phase at 100 K prior to complete amorphization, which is supported by molecular dynamics calculations. The phase transition pathways show clear temperature dependence: direct amorphization without an intermediate phase is observed at 133 K, while at 145 K a direct Ih-to-IX transformation is observed; decompression of HDA shows a transition to low-density amorphous ice at 96 K and ∼1  Pa, to ice Ic at 135 K and to ice IX at 145 K...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341045/approach-to-infants-born-through-meconium-stained-amniotic-fluid-evolution-based-on-evidence
#3
Munmun Rawat, Sushma Nangia, Praveen Chandrasekharan, Satyan Lakshminrusimha
Meconium-stained amniotic fluid (MSAF) during delivery is a marker of fetal stress. Neonates born through MSAF often need resuscitation and are at risk of meconium aspiration syndrome (MAS), air leaks, hypoxic-ischemic encephalopathy, extracorporeal membrane oxygenation (ECMO), and death. The neonatal resuscitation approach to MSAF has evolved over the last three decades. Previously, nonvigorous neonates soon after delivery were suctioned under the vocal cords with direct visualization technique using a meconium aspirator...
January 16, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29340345/intraosseous-temperature-changes-during-implant-site-preparation-in-vitro-comparison-of-thermocouples-and-infrared-thermography
#4
Sönke Harder, Christopher Egert, Sandra Freitag-Wolf, Christian Mehl, Matthias Kern
PURPOSE: Implant-supported dental prostheses are based on the principle of osseointegration, and the success of dental implantation depends on adequate formation of this intimate bone-to-implant contact. The application of heat during the drilling procedure leads to a rise in intraosseous temperature at the prospective implant site, which may result in various complications. The purpose of the present study was to compare the ability of thermocouples and infrared thermography to detect changes in intraosseous temperature during dental implant site preparation...
January 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29340166/withdrawal-of-antihypertensive-therapy-in-people-with-dementia-feasibility-study
#5
Veronika van der Wardt, Jennifer K Burton, Simon Conroy, Tomas Welsh, Pip Logan, Jaspal Taggar, Lukasz Tanajewski, John Gladman
Background: This study explored the feasibility of a randomised controlled withdrawal trial of antihypertensive medication in normotensive people with dementia. Feasibility aspects included response, recruitment, exclusion and drop-out rates, suitability of outcome measures, acceptability of study procedures and an indicative economic evaluation for a randomised controlled trial. Methods: A cohort study attempting the withdrawal of antihypertensive drugs where appropriate and a feasibility study of home-based blood pressure monitoring, in people with dementia treated for hypertension, was undertaken...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29339974/multidisciplinary-treatment-of-patients-with-diabetes-and-hypertension-experience-of-a-brazilian-center
#6
Thiago Veiga Jardim, Sayuri Inuzuka, Luan Galvão, Leandra Anália Freitas Negretto, Rogério Orlow de Oliveira, Wanessa Faria Sá, Haroldo Silva de Souza, Andrea Crisitina Sousa, Patricia Silva Carneiro, Weimar Kunz Sebba Barroso, Ana Luiza Lima Sousa, Paulo César Veiga Jardim
Background: Although multidisciplinary treatment is recommended for type 2 diabetes mellitus and hypertension (HTN), there is a lack of scientific literature supporting the hypothesis of extending this treatment strategy to patients with both diabetes and HTN. Aiming to report results of long-term multidisciplinary treatment for these patients and identify strategies to improve their management, we conducted this study. Methods: Data of patients with diabetes and HTN with regular follow-up visits in a multidisciplinary HTN treatment center from Brazil's Midwest were retrospectively assessed...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29337961/how-the-evolution-of-multicellularity-set-the-stage-for-cancer
#7
REVIEW
Anna S Trigos, Richard B Pearson, Anthony T Papenfuss, David L Goode
Neoplastic growth and many of the hallmark properties of cancer are driven by the disruption of molecular networks established during the emergence of multicellularity. Regulatory pathways and molecules that evolved to impose regulatory constraints upon networks established in earlier unicellular organisms enabled greater communication and coordination between the diverse cell types required for multicellularity, but also created liabilities in the form of points of vulnerability in the network that when mutated or dysregulated facilitate the development of cancer...
January 16, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29337720/update-on-the-role-of-actovegin-in-musculoskeletal-medicine-a-review-of-the-past-10-years
#8
James Brock, David Golding, Paul M Smith, Len Nokes, Alvin Kwan, Paul Y F Lee
BACKGROUND: Actovegin is a biological drug with a controversial history of use in the treatment of sports injuries during the past 60 years. Particular concerns have been raised about its ergogenic potential to enhance performance, but some of these have been based on little more than anecdote. OBJECTIVES: In this article, we review the most recent scientific evidence to determine the clinical efficacy, safety profile, and legal status of Actovegin. METHODS: We considered all studies directly commenting on experience with Actovegin use as the primary intervention within the past 10 years...
January 15, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29336441/a-high-pressure-study-of-calmodulin-ligand-interactions-using-small-angle-x-ray-and-elastic-incoherent-neutron-scattering
#9
Süleyman Cinar, Samy Al-Ayoubi, Christian Sternemann, Judith Peters, Roland Winter, Claus Czeslik
Calmodulin (CaM) is a Ca2+ sensor and mediates Ca2+ signaling through binding of numerous target ligands. The binding of ligands by Ca2+-saturated CaM (holo-CaM) is governed by attractive hydrophobic and electrostatic interactions that are weakened under high pressure in aqueous solutions. Moreover, the potential formation of void volumes upon ligand binding creates a further source of pressure sensitivity. Hence, high pressure is a suitable thermodynamic variable to probe protein-ligand interactions. In this study, we compare the binding of two different ligands to holo-CaM as a function of pressure by using X-ray and neutron scattering techniques...
January 16, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29336216/sulfamethoxazole-removal-in-membrane-photocatalytic-reactor-system-experimentation-and-modelling
#10
Raju C Asha, M S Priyanka Yadav, Mathava Kumar
In this study, the efficacy of membrane-photocatalytic reactor (MPR) in sulfamethoxazole (SMX) removal was explored at a fixed initial SMX concentration, i.e. 100 mg/L. A supported catalyst, i.e. TiO2 on granular activated carbon (GAC-TiO2), was used for MPR experiments. The SMX removal efficiency of the MPR was investigated under a range of hydraulic retention time (i.e. HRT from 51 ∼ 152.5 min) and TiO2 catalyst dosage (55 ∼ 550 mg/L). A maximum SMX removal efficiency of 83.6% was observed under 220 mg/L catalyst dosage and 80 min HRT...
January 16, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29335615/marinobufagenin-is-related-to-elevated-central-and-24-h-systolic-blood-pressures-in-young-black-women-the-african-predict-study
#11
Michél Strauss, Wayne Smith, Wen Wei, Olga V Fedorova, Aletta E Schutte
Marinobufagenin (MBG) is an endogenous steroidal α1-Na+K+-ATPase inhibitor. Because of its role in sodium handling, MBG has been associated with both antihypertensive and prohypertensive effects in normal physiology and pathology. MBG is positively associated with blood pressure in Dahl salt-sensitive rats exhibiting a similar hypertensive phenotype to black populations, characterized by impaired urinary Na+ excretion. However, clinical studies exploring blood pressure (BP)-related effects of MBG in black populations are scant...
January 15, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29335324/prevalence-of-primary-aldosteronism-in-primary-care-a-cross-sectional-study
#12
Sabine C Käyser, Jaap Deinum, Wim Jc de Grauw, Bianca Wm Schalk, Hans Jhj Bor, Jacques Wm Lenders, Tjard R Schermer, Marion Cj Biermans
BACKGROUND: Primary aldosteronism (PA) is the most frequent cause of secondary hypertension. Reported prevalences of PA vary considerably because of a large heterogeneity in study methodology. AIM: To examine the proportion of patients with PA among patients with newly diagnosed, never treated hypertension. DESIGN AND SETTING: A cross-sectional study set in primary care. METHOD: GPs measured aldosterone and renin in adult patients with newly diagnosed, never treated hypertension...
January 15, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29335239/comparing-diet-and-exercise-monitoring-using-smartphone-app-and-paper-diary-a-two-phase-intervention-study
#13
Florence Jimoh, Elizabeth K Lund, Linda J Harvey, Catherine Frost, W James Lay, Mark A Roe, Rachel Berry, Paul M Finglas
BACKGROUND: There is increasing recognition that personalized approaches may be more effective in helping people establish healthier eating patterns and exercise more, and that this approach may be particularly effective in adolescents. OBJECTIVE: The objective of this study was to investigate the use of a smartphone app (FoodWiz2) in supporting healthy lifestyle choices in adolescence. METHODS: Participants (N=34: 11 male, 23 female) aged 16-19 years in full- or part-time education were recruited from sixth form colleges, schools, and other further education establishments in Norfolk and Suffolk, United Kingdom, between February and May 2015...
January 15, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29334488/severe-intraocular-pressure-elevation-after-intracameral-healon-5-viscoelastic-support-for-post-operative-hypotony-after-xen-gel-stent-insertion
#14
Alice Bruynseels, Freda Sii, Imran Masood, Peter Shah
PURPOSE: To describe (i) a novel case of severe intraocular pressure (IOP) elevation due to intracameral Healon 5 for management of early post-operative hypotony following XEN Gel Stent insertion and (ii) the management of this complication. METHODS: A case report. RESULTS: A 52-year-old male, with primary open angle glaucoma and suboptimal left IOP control on maximally tolerated medical therapy, was managed with XEN Gel Stent insertion at another tertiary eye unit...
January 12, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29334229/physical-and-psychological-health-of-carers-of-young-people-with-first-episode-psychosis
#15
Abner Weng Cheong Poon, Jackie Curtis, Philip Ward, Celia Loneragan, Julia Lappin
OBJECTIVE: Carers of people with psychosis may experience psychological distress and caregiving burden. However, few studies have examined both psychological and physical health of carers of young people with first episode psychosis (FEP). METHOD: A total of 32 young people with FEP and 42 of their carers were recruited from a mental health service. Standardised scales were administered to assess carers' psychological distress and risk for development of Type 2 diabetes...
January 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29333566/principles-of-management-of-central-nervous-system-infections
#16
REVIEW
Sunit Singhi, Suresh Kumar Angurana
CNS infections in children are medical emergency and are associated with high mortality and morbidity. For diagnosis, a high index of suspicion is required. Clinical assessment should be supplemented by laboratory investigations including CSF Gram stain and cultures, blood culture, PCR on CSF, serological tests, and imaging. Commonly associated life threatening complications include coma, seizure, raised intracranial pressure (ICP), focal deficits, shock, respiratory failure, and fluid and electrolyte abnormalities...
January 15, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29332629/psychobiological-stress-in-vital-exhaustion-findings-from-the-men-stress-40-study
#17
Emilou Noser, Susanne Fischer, Jessica Ruppen, Ulrike Ehlert
OBJECTIVE: Despite the increased risk for cardiovascular morbidity associated with vital exhaustion (VE), the underlying pathophysiological mechanisms remain unclear. Allostatic load may constitute the missing link between VE and cardiovascular diseases. The aim of the present study was to investigate whether men with different degrees of VE would differ in terms of allostatic load, chronic stress, and social support. METHODS: The Men Stress 40+ study sample consisted of N=121 apparently healthy men aged 40 to 75years...
February 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29332061/design-and-implementation-of-an-advanced-telemedicine-model-for-the-rural-people-of-bangladesh
#18
Uzzal Kumar Prodhan, Mohammad Zahidur Rahman, Israt Jahan
OBJECTIVES: Telemedicine based healthcare service faces different difficulties especially in the remote people of Bangladesh. The objective of this study was to implement an advanced telemedicine model in order to provide the healthcare services for the rural people of Bangladesh. METHODS: We developed the telemedicine model using an ardunio based low cost portable telemedicine tool kit by interfacing android application. Then we collected ECG, blood pressure, temperature, concentration of glucose in blood, SPO2, body position, airflow, height and weight through our developed model...
January 5, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29331685/nucleic-adaptability-of-heterokaryons-to-fungicides-in-a-multinucleate-fungus-sclerotinia-homoeocarpa
#19
Dylan Kessler, Hyunkyu Sang, Amanda Bousquet, Jonathan P Hulvey, Dawlyn Garcia, Siyeon Rhee, Yoichiro Hoshino, Toshihiko Yamada, Geunhwa Jung
Sclerotinia homoeocarpa is the causal organism of dollar spot in turfgrasses and is a multinucleate fungus with a history of resistance to multiple fungicide classes. Heterokaryosis gives rise to the coexistence of genetically distinct nuclei within a cell, which contributes to genotypic and phenotypic plasticity in multinucleate fungi. We demonstrate that field isolates, resistant to either a demethylation inhibitor or methyl benzimidazole carbamate fungicide, can form heterokaryons with resistance to each fungicide and adaptability to serial combinations of different fungicide concentrations...
January 10, 2018: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/29331364/picky-eating-pressuring-feeding-and-growth-in-toddlers
#20
Julie C Lumeng, Alison L Miller, Danielle Appugliese, Katherine Rosenblum, Niko Kaciroti
Several common theoretical frameworks have posited causal pathways between picky eating, pressuring feeding, and growth in early childhood. The evidence to support these pathways is limited. This observational cohort study sought to examine the cross-lagged associations between mother-reported pressuring feeding, mother-reported child picky eating, and measured weight-for-length z-score (WLZ) across child ages 21, 27, and 33 months (n = 244). Cross-lagged analysis was used to evaluate longitudinal associations between these three constructs...
January 10, 2018: Appetite
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