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Low dose computed tomography

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https://www.readbyqxmd.com/read/29349698/third-generation-dual-source-ct-enables-accurate-diagnosis-of-coronary-restenosis-in-all-size-stents-with-low-radiation-dose-and-preserved-image-quality
#1
Yuehua Li, Mengmeng Yu, Wenbin Li, Zhigang Lu, Meng Wei, Jiayin Zhang
OBJECTIVES: To investigate the diagnostic performance of low dose stent imaging in patients with large (≥ 3 mm) and small (< 3 mm) calibre stents by third-generation dual-source CT. METHODS: Symptomatic patients suspected of having in-stent restenosis (ISR) were prospectively enrolled. Coronary computed tomography angiography (CCTA) and invasive coronary angiography (ICA) were performed within 1 month for correlation. Binary ISR was defined as an in-stent neointimal proliferation with diameter stenosis ≥ 50%...
January 18, 2018: European Radiology
https://www.readbyqxmd.com/read/29344306/131i-labeled-copper-sulfide-loaded-microspheres-to-treat-hepatic-tumors-via-hepatic-artery-embolization
#2
Qiufang Liu, Yuyi Qian, Panli Li, Sihang Zhang, Jianjun Liu, Xiaoguang Sun, Michael Fulham, Dagan Feng, Gang Huang, Wei Lu, Shaoli Song
Purpose: Transcatheter hepatic artery embolization therapy is a minimally invasive alternative for treating inoperable liver cancer but recurrence is frequent. Multifunctional agents, however, offer an opportunity for tumor eradication. In this study, we were aim to synthesized poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating hollow CuS nanoparticles (HCuSNPs) and paclitaxel (PTX) that were then labeled with radioiodine-131 (131I) to produce 131I-HCuSNPs-MS-PTX. This compound combines the multi-theranostic properties of chemotherapy, radiotherapy and photothermal therapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29344194/chronic-myeloid-leukemia-following-repeated-diagnostic-x-ray-exposure-for-the-treatment-of-recurrent-spontaneous-pneumothorax-in-a-patient-with-ankylosing-spondylitis-a-case-report-and-literature-review
#3
Fang-He Ju, Xu-Bo Gong, Ting-Zhen Xu, Li-Bin Jiang, Hui-Hua Hong, Zhen Wang
Previous studies have indicated that X-ray irradiation may increase the risk of chronic myeloid leukemia (CML), and the incidence of spontaneous pneumothorax in patients with ankylosing spondylitis (AS) is higher than in the general population. Patients with AS usually develop spontaneous pneumothorax several years after the diagnosis of AS. The present study reports the unusual case and complicated clinical history of a 29-year-old man with recurrent pneumothorax and AS, who developed CML following repeated exposure to low doses of radiation via diagnostic X-rays and chest computed tomography imaging...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343293/identification-of-preoperative-prediction-factors-of-tumor-subtypes-for-patients-with-solitary-ground-glass-opacity-pulmonary-nodules
#4
Meishuang Li, Yanan Wang, Yulong Chen, Zhenfa Zhang
BACKGROUND: Recent wide spread use of low-dose helical computed tomography for the screening of lung cancer have led to an increase in the detection rate of very faint and smaller lesions known as ground-glass opacity nodules. The purpose of this study was to investigate the clinical factors of lung cancer patients with solitary ground-glass opacity pulmonary nodules on computed tomography. METHODS: A total of 423 resected solitary ground-glass opacity nodules were retrospectively evaluated...
January 17, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29338789/diagnosis-treatment-and-response-assessment-in-solitary-plasmacytoma-updated-recommendations-from-a-european-expert-panel
#5
REVIEW
J Caers, B Paiva, E Zamagni, X Leleu, J Bladé, S Y Kristinsson, C Touzeau, N Abildgaard, E Terpos, R Heusschen, E Ocio, M Delforge, O Sezer, M Beksac, H Ludwig, G Merlini, P Moreau, S Zweegman, M Engelhardt, L Rosiñol
Solitary plasmacytoma is an infrequent form of plasma cell dyscrasia that presents as a single mass of monoclonal plasma cells, located either extramedullary or intraosseous. In some patients, a bone marrow aspiration can detect a low monoclonal plasma cell infiltration which indicates a high risk of early progression to an overt myeloma disease. Before treatment initiation, whole body positron emission tomography-computed tomography or magnetic resonance imaging should be performed to exclude the presence of additional malignant lesions...
January 16, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29338501/does-the-evidence-support-the-implementation-of-lung-cancer-screening-with-low-dose-computed-tomography
#6
Paul F Pinsky
No abstract text is available yet for this article.
January 17, 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29336865/continuous-hyperfractionated-accelerated-radiotherapy-chart-for-non-small-cell-lung-cancer-nsclc-7-years-experience-from-nine-uk-centres
#7
P Sanganalmath, J E Lester, A G Bradshaw, T Das, C Esler, A E F Roy, E Toy, J F Lester, M Button, P Wilson, C Comins, P Atherton, R Pickles, K Foweraker, G A Walker, M Keni, M Q Hatton
AIM: Continuous hyperfractionated accelerated radiotherapy (CHART) remains an option to treat non-small cell lung cancer (NSCLC; NICE, 2011). We have previously published treatment outcomes from 1998-2003 across five UK centres. Here we update the UK CHART experience, reporting outcomes and toxicities for patients treated between 2003 and 2009. MATERIALS AND METHODS: UK CHART centres were invited to participate in a retrospective data analysis of NSCLC patients treated with CHART from 2003 to 2009...
January 11, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29333114/carcinogenesis-induced-by-low-dose-radiation
#8
Igor Piotrowski, Katarzyna Kulcenty, Wiktoria Maria Suchorska, Agnieszka Skrobała, Małgorzata Skórska, Marta Kruszyna-Mochalska, Anna Kowalik, Weronika Jackowiak, Julian Malicki
Background: Although the effects of high dose radiation on human cells and tissues are relatively well defined, there is no consensus regarding the effects of low and very low radiation doses on the organism. Ionizing radiation has been shown to induce gene mutations and chromosome aberrations which are known to be involved in the process of carcinogenesis. The induction of secondary cancers is a challenging long-term side effect in oncologic patients treated with radiation. Medical sources of radiation like intensity modulated radiotherapy used in cancer treatment and computed tomography used in diagnostics, deliver very low doses of radiation to large volumes of healthy tissue, which might contribute to increased cancer rates in long surviving patients and in the general population...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29330481/fdxr-is-a-biomarker-of-radiation-exposure-in-vivo
#9
Gráinne O'Brien, Lourdes Cruz-Garcia, Matthäus Majewski, Jakub Grepl, Michael Abend, Matthias Port, Aleš Tichý, Igor Sirak, Andrea Malkova, Ellen Donovan, Lone Gothard, Sue Boyle, Navita Somaiah, Elizabeth Ainsbury, Lucyna Ponge, Krzysztof Slosarek, Leszek Miszczyk, Piotr Widlak, Edward Green, Neel Patel, Mahesh Kudari, Fergus Gleeson, Volodymyr Vinnikov, Viktor Starenkiy, Sergii Artiukh, Leonid Vasyliev, Azfar Zaman, Christophe Badie
Previous investigations in gene expression changes in blood after radiation exposure have highlighted its potential to provide biomarkers of exposure. Here, FDXR transcriptional changes in blood were investigated in humans undergoing a range of external radiation exposure procedures covering several orders of magnitude (cardiac fluoroscopy, diagnostic computed tomography (CT)) and treatments (total body and local radiotherapy). Moreover, a method was developed to assess the dose to the blood using physical exposure parameters...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29328048/a-biomechanical-modeling-guided-simultaneous-motion-estimation-and-image-reconstruction-technique-smeir-bio-for-4d-cbct-reconstruction
#10
Xiaokun Huang, You Zhang, Jing Wang
Reconstructing four-dimensional cone-beam computed tomography (4D-CBCT) images directly from respiratory phase-sorted traditional 3D-CBCT projections can capture target motion trajectory, reduce motion artifacts, and reduce imaging dose and time. However, the limited numbers of projections in each phase after phase-sorting decreases CBCT image quality under traditional reconstruction techniques. To address this problem, we developed a simultaneous motion estimation and image reconstruction (SMEIR) algorithm, an iterative method that can reconstruct higher quality 4D-CBCT images from limited projections using an inter-phase intensity-driven motion model...
January 12, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29325548/a-pre-post-study-testing-a-lung-cancer-screening-decision-aid-in-primary-care
#11
Daniel S Reuland, Laura Cubillos, Alison T Brenner, Russell P Harris, Bailey Minish, Michael P Pignone
BACKGROUND: The United States Preventive Services Task Force (USPSTF) issued recommendations for older, heavy lifetime smokers to complete annual low-dose computed tomography (LDCT) scans of the chest as screening for lung cancer. The USPSTF recommends and the Centers for Medicare and Medicaid Services require shared decision making using a decision aid for lung cancer screening with annual LDCT. Little is known about how decision aids affect screening knowledge, preferences, and behavior...
January 12, 2018: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29322068/measuring-temporal-stability-of-positron-emission-tomography-standardized-uptake-value-bias-using-long-lived-sources-in-a-multicenter-network
#12
Darrin Byrd, Rebecca Christopfel, Grae Arabasz, Ciprian Catana, Joel Karp, Martin A Lodge, Charles Laymon, Eduardo G Moros, Mikalai Budzevich, Sadek Nehmeh, Joshua Scheuermann, John Sunderland, Jun Zhang, Paul Kinahan
Positron emission tomography (PET) is a quantitative imaging modality, but the computation of standardized uptake values (SUVs) requires several instruments to be correctly calibrated. Variability in the calibration process may lead to unreliable quantitation. Sealed source kits containing traceable amounts of [Formula: see text] were used to measure signal stability for 19 PET scanners at nine hospitals in the National Cancer Institute's Quantitative Imaging Network. Repeated measurements of the sources were performed on PET scanners and in dose calibrators...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29321112/the-evaluation-and-management-of-urolithiasis-in-the-emergency-department-a-review-of-the-literature
#13
REVIEW
Michael Gottlieb, Brit Long, Alex Koyfman
BACKGROUND: Urolithiasis is a common condition in the U.S. Patients frequently present to the emergency department (ED) for care, including analgesia and treatments to facilitate stone passage. OBJECTIVE: With the new evidence concerning the evaluation and treatment of urolithiasis, this review summarizes current literature regarding the ED management of urolithiasis. DISCUSSION: Urolithiasis occurs primarily through supersaturation of urine and commonly presents with flank pain, hematuria, and nausea/vomiting...
January 5, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29321038/cross-sectional-study-to-assess-the-accuracy-of-electronic-health-record-data-to-identify-patients-in-need-of-lung-cancer-screening
#14
Allison M Cole, Bethann Pflugeisen, Malaika R Schwartz, Sophie Cain Miller
OBJECTIVE: Lung cancer is the leading cause of cancer death in the United States [Siegel et al. in CA Cancer J Clin 66:7-30, 1]. However, evidence from clinical trials indicates that annual low-dose computed tomography screening reduces lung cancer mortality [Humphrey et al. in Ann Intern Med 159:411-420, 2]. The objective of this study is to report results of a study designed to assess the sensitivity, specificity, and positive and negative predictive value of an electronic health record (EHR) query in comparison to patient self-report, to identify patients who may benefit from lung cancer screening...
January 10, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29320863/evaluation-of-an-iterative-model-based-ct-reconstruction-algorithm-by-intra-patient-comparison-of-standard-and-ultra-low-dose-examinations
#15
Peter B Noël, Stephan Engels, Thomas Köhler, Daniela Muenzel, Daniela Franz, Michael Rasper, Ernst J Rummeny, Martin Dobritz, Alexander A Fingerle
Background The explosive growth of computer tomography (CT) has led to a growing public health concern about patient and population radiation dose. A recently introduced technique for dose reduction, which can be combined with tube-current modulation, over-beam reduction, and organ-specific dose reduction, is iterative reconstruction (IR). Purpose To evaluate the quality, at different radiation dose levels, of three reconstruction algorithms for diagnostics of patients with proven liver metastases under tumor follow-up...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29319401/age-dependent-differences-in-dna-damage-after-in-vitro-ct-exposure
#16
Maria Gomolka, Ursula Oestreicher, Ute Roessler, Daniel Samaga, David Endesfelder, Peter Lang, Klement Neumaier, Claus Belka, Markus Niemeyer, Marion Kiechle, Uwe Hasbargen, Christoph Hübener, Hans-Joachim Kirlum, Ulrike Kulka, Albert Rosenberger, Linda Walsh, Sarah Baatout, Ausra Kesminiene, Carita Lindholm
PURPOSE: Age dependent radiation sensitivity for DNA damage after in vitro blood exposure by computer tomography (CT) was investigated. MATERIALS AND METHODS: Radiation biomarkers (dicentrics and gammaH2AX) in blood samples of newborns, children under 5 years and adults after sham exposure (0 mGy), low dose (41 mGy) and high dose (978 mGy) in vitro CT exposure were analysed. RESULTS: Significantly higher levels of dicentric induction were found for the single and combined newborns/children group compared to adults, by a factor of 1...
January 10, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29319052/measurement-of-lung-cancer-tumor-markers-in-a-glass-wool-company-workers-exposed-to-respirable-synthetic-vitreous-fiber-and-dust
#17
Shabnam Abtahi, Mahyar Malekzadeh, Ghafour Nikravan, Abbas Ghaderi
BACKGROUND: Occupational exposures to respirable synthetic vitreous fiber (SVF) and dust are associated with many lung diseases including lung cancer. Low-dose computed tomography is used for screening patients who are highly suspicious of having lung carcinoma. However, it seems not to be cost-effective. Serum biomarkers could be a useful tool for the surveillance of occupational exposure, by providing the possibility of diagnosing lung cancer in its early stages. OBJECTIVE: To determine if serum carcinoembryonic antigen (CEA) and cytokeratin fragment (CYFRA) 21-1 levels in workers exposed more than normal population to respirable SVF and dust may be used as indicators of progression towards lung cancer...
January 2018: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29318928/cone-beam-computed-tomography-a-new-low-dose-three-dimensional-imaging-technique-for-assessment-of-bone-erosions-in-rheumatoid-arthritis-reliability-assessment-and-comparison-with-conventional-radiography-a-barfot-study
#18
Y Aurell, Mle Andersson, K Forslind
OBJECTIVES: To determine the intra- and inter-observer agreement of erosions detected and scored with cone-beam computed tomography (CBCT) of bones in the hands and feet, and to compare CBCT with conventional radiography (CR) for assessment of bone erosions in patients with long-standing rheumatoid arthritis (RA). METHOD: Thirty patients with long-standing RA from the Better Anti-Rheumatic PharmacOTherapy (BARFOT) cohort were examined with CBCT and CR of hands and feet at their 15 year follow-up...
January 10, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29314524/current-lung-cancer-screening-practice-amongst-general-practitioners-in-western-australia-a-cross-sectional-study
#19
David Manners, Helen Wilcox, Annette McWilliams, Francesco Piccolo, Helena Liira, Fraser Brims
Lung cancer screening with low dose computed tomography (LDCT) is recommended in the USA and Canada for high-risk smokers but not in Australia. We administered a cross-sectional survey to Western Australian general practitioners (GP). The majority (64/93, 69%) reported requesting a screening chest X-ray (42/93, 45%) and/or LDCT (38/93, 41%) in the past year. LDCT screening was more common if the GP had received education from radiology practices (odds ratio (OR) 2.81, P = 0.03) or if they believed screening is funded by the Medical Benefits Scheme (OR 3...
January 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29313653/lung-cancer-screening-and-evaluation-of-patients-with-solitary-pulmonary-nodules
#20
Timothy F Mott
Low-dose computed tomography (CT) scan is the only modality currently considered acceptable for lung cancer screening in high-risk populations. Screening recommendations vary. The US Preventive Services Task Force recommends annual low-dose CT scan to screen high-risk patients (ie, asymptomatic patients ages 55 to 80 years with a 30 pack-year smoking history and who currently smoke or have quit within the previous 15 years). The American Academy of Family Physicians recommends a shared decision-making discussion between the clinician and patient regarding the benefits and potential harms of screening...
January 2018: FP Essentials
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