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Low dose computed tomography

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https://www.readbyqxmd.com/read/29141395/beliefs-and-intentions-to-undergo-lung-cancer-screening-among-korean-males
#1
Nhung Cam Bui, Yoon Young Le, Mina Suh, Boyoung Park, Hyunsoon Cho, Yeol Kim, Kui Son Choi
Purpose: Low-dose computed tomography (LDCT) has been reported as an effective screening method for lung cancer in high-risk populations. We aimed to examine willingness to be screened among Korean males using LDCT and to determine factors associated with lung cancer screening intentions (LCS) based on the Health Belief Model (HBM). Materials and Methods: Data were obtained from the 2015 Korean National Cancer Screening Survey, a cross-sectional survey that utilized nationally representative random sampling...
November 16, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29137847/comparison-between-radiological-semantic-features-and-lung-rads-in-predicting-malignancy-of-screen-detected-lung-nodules-in-the-national-lung-screening-trial
#2
Qian Li, Yoganand Balagurunathan, Ying Liu, Jin Qi, Matthew B Schabath, Zhaoxiang Ye, Robert J Gillies
RATIONALE: Lung computed tomography (CT) Screening Reporting and Data System (lung-RADS) has standardized follow-up and management decisions in lung cancer screening. To date, little is known how lung-RADS classification compares with radiological semantic features in risk prediction and diagnostic discrimination. OBJECTIVES: To compare the performance of radiological semantic features and lung-RADS in predicting nodule malignancy in lung cancer screening. METHODS: We used data and low-dose CT (LDCT) images from the National Lung Screening Trial (NLST)...
October 13, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29131773/update-on-cardiovascular-applications-of-multienergy-ct
#3
Kevin Kalisz, Sandra Halliburton, Suhny Abbara, Jonathon A Leipsic, Moritz H Albrecht, U Joseph Schoepf, Prabhakar Rajiah
Advances in scanner technology enabling shorter scan times, improvements in spatial and temporal resolution, and more dose-efficient data reconstruction coupled with rapidly growing evidence from clinical trials have established computed tomography (CT) as an important imaging modality in the evaluation of cardiovascular disorders. Multienergy (or spectral or dual-energy) CT is a relatively recent advance in which attenuation data from different energies are used to characterize materials beyond what is possible at conventional CT...
November 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29125035/cone-beam-computed-tomography-cbct-for-adaptive-image-guided-head-and-neck-radiation-therapy
#4
Christian A Hvid, Ulrik V Elstrøm, Kenneth Jensen, Cai Grau
BACKGROUND: Adaptive (ART) and image guided radiation therapy (IGRT) can improve target coverage and reduce unnecessary irradiation of organs at risk (OAR). The purpose of this study is to report the results of using mid-course imaging and a novel workflow with cone-beam computed tomography (CBCT) surveillance of dose to OAR to trigger adaptive replanning in head and neck radiotherapy. MATERIAL AND METHODS: Impact of radiation therapist (RTT) managed match protocol and mid-course imaging was assessed in two cohorts of consecutive patients receiving RT to the head and neck region, using computed tomography (CT) and CBCT-based dose verification respectively...
November 10, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29122046/model-based-cost-effectiveness-of-conventional-and-innovative-chemo-radiation-in-lung-cancer
#5
Mathilda L Bongers, Dirk de Ruysscher, Cary Oberije, Philippe Lambin, Carin A Uyl-de Groot, José Belderbos, Veerle M H Coupé
INTRODUCTION: Optimizing radiotherapy with or without chemotherapy through advanced imaging and accelerated radiation schemes shows promising results in locally advanced non-small-cell lung cancer (NSCLC). This study compared the cost-effectiveness of positron emission tomography-computed tomography based isotoxic accelerated sequential chemo-radiation (SRT2) and concurrent chemo-radiation with daily low-dose cisplatin (CRT2) with standard sequential (SRT1) and concurrent chemo-radiation (CRT1)...
November 10, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29121966/radioprotective-agents-to-prevent-cellular-damage-due-to-ionizing-radiation
#6
REVIEW
Tyler A Smith, Daniel R Kirkpatrick, Sean Smith, Trevor K Smith, Tate Pearson, Aparna Kailasam, Kortney Z Herrmann, Johanna Schubert, Devendra K Agrawal
Medical imaging has become a central component of patient care to ensure early and accurate diagnosis. Unfortunately, many imaging modalities use ionizing radiation to generate images. Ionizing radiation even in low doses can cause direct DNA damage and generate reactive oxygen species and free radicals, leading to DNA, protein, and lipid membrane damage. This cell damage can lead to apoptosis, necrosis, teratogenesis, or carcinogenesis. As many as 2% of cancers (and an associated 15,000 deaths annually) can be linked to computed tomography exposure alone...
November 9, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29116054/non-rigid-ct-cbct-to-cbct-registration-for-online-external-beam-radiotherapy-guidance
#7
Cornel Zachiu, Baudouin Denis de Senneville, Rob H N Tijssen, Alexis N T J Kotte, Antonetta Christina Houweling, Linda G W Kerkmeijer, Jan J W Lagendijk, Chrit T W Moonen, Mario G Ries
Image-guided external beam radiotherapy (EBRT) allows radiation dose deposition with a high degree of accuracy and precision. Guidance is usually achieved by estimating the displacements, via image registration, between cone beam computed tomography (CBCT) and computed tomography (CT) images acquired at different stages of the therapy. The resulting displacements are then used to reposition the patient such that the location of the tumor at the time of treatment matches its position during planning. Moreover, ongoing research aims to use CBCT-CT image registration for online plan adaptation...
November 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29114620/reducing-radiation-dose-and-enhancing-imaging-quality-of-4dct-for-radiation-therapy-using-iterative-reconstruction-algorithms
#8
George Noid, An Tai, Guang-Pei Chen, Jared Robbins, X Allen Li
Purpose: Four-dimensional computed tomography (CT) images are typically used to quantify the necessary internal target volumes for thoracic and abdominal tumors. However, 4-dimensional CT is typically associated with excessive imaging dose to patients and the situation is exacerbated when using repeat 4-dimensional CT imaging on a weekly or daily basis throughout fractionated therapy. The aim of this work is to evaluate an iterative reconstruction (IR) algorithm that helps reduce the imaging dose to the patient while maintaining imaging quality as quantified by point spread function and contrast-to-noise ratios (CNRs)...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29114609/dose-escalation-with-an-imrt-technique-in-15-to-28-fractions-is-better-tolerated-than-standard-doses-of-3dcrt-for-lapc
#9
Lauren E Colbert, Shalini Moningi, Awalpreet Chadha, Ahmed Amer, Yeonju Lee, Robert A Wolff, Gauri Varadhachary, Jason Fleming, Matthew Katz, Prajnan Das, Sunil Krishnan, Eugene J Koay, Peter Park, Christopher H Crane, Cullen M Taniguchi
Purpose: To review acute and late toxicities after chemoradiation for locally advanced pancreatic ductal adenocarcinoma in patients who were treated with escalated dose radiation (EDR). Methods and materials: Maximum Common Terminology Criteria for Adverse Events Version 4.0 acute toxicities (AT) during radiation and within 60 days after radiation were recorded for both acute gastrointestinal toxicity and overall toxicity (OT). Late toxicities were also recorded...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29107992/software-assisted-dosimetry-in-peptide-receptor-radionuclide-therapy-with-177lutetium-dotatate-for-various-imaging-scenarios
#10
Dennis Kupitz, Christoph Wetz, Heiko Wissel, Florian Wedel, Ivayla Apostolova, Thekla Wallbaum, Jens Ricke, Holger Amthauer, Oliver S Grosser
In peptide receptor radionuclide therapy (PRRT) of patients with neuroendocrine neoplasias (NENs), intratherapeutic dosimetry is mandatory for organs at risk (e.g. kidneys) and tumours. We evaluated commercial dosimetry software (Dosimetry Toolkit) using varying imaging scenarios, based on planar and/or tomographic data, regarding the differences in calculated organ/tumour doses and the use for clinical routines. A total of 16 consecutive patients with NENs treated by PRRT with 177Lu-DOTATATE were retrospectively analysed...
2017: PloS One
https://www.readbyqxmd.com/read/29107933/local-administration-of-calcitonin-inhibits-alveolar-bone-loss-in-an-experimental-periodontitis-in-rats
#11
Chie Wada-Mihara, Hiroyuki Seto, Hirofumi Ohba, Kaku Tokunaga, Jun-Ichi Kido, Toshihiko Nagata, Koji Naruishi
Calcitonin (CTN), a calcium regulatory hormone, promotes calcium diuresis from the kidney and suppresses bone resorption. The objective of this study was to evaluate whether the topical and intermittent application of CTN inhibits alveolar bone resorption using ligature-induced experimental periodontitis in rats. Experimental periodontitis was induced by placing a nylon ligature around maxillary molars of 8-week-old male Wistar rats for 20 days. Thirty-two rats were divided into four groups: basal sham control group, periodontitis group, periodontitis plus 0...
November 3, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29104659/estimation-of-effective-doses-in-pediatric-x-ray-computed-tomography-examination
#12
Hideki Obara, Midori Takahashi, Kazuya Kudou, Yasushi Mariya, Yoshihiro Takai, Ikuo Kashiwakura
X-ray computed tomography (CT) images are used for diagnostic and therapeutic purposes in various medical disciplines. In Japan, the number of facilities that own diagnostic CT equipment, the number of CT examinations and the number of CT scanners increased by ~1.4-fold between 2005 and 2011. CT operators (medical radiological technologists, medical physicists and physicians) must understand the effective doses for examinations at their own institutions and carefully approach each examination. In addition, the patients undergoing the examination (as well as his/her family) must understand the effective dose of each examination in the context of the cumulative dose...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29100768/computed-tomography-scans-in-patients-with-young-adult-hip-pain-carry-a-lifetime-risk-of-malignancy
#13
James D Wylie, Peter A Jenkins, James T Beckmann, Christopher L Peters, Stephen K Aoki, Travis G Maak
PURPOSE: To calculate the lifetime risk of malignancy in young adult patients with hip pain using 5 different imaging and radiation dose protocols with or without pre- and postoperative computed tomography (CT). METHODS: Radiographic and CT patient radiation doses were retrospectively reviewed. Imaging protocols for hip pain composed of radiographs with or without pre- and postoperative CT scans were modeled and radiation doses were estimated using the PCXMC computer code...
October 31, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29100255/multidetector-computed-tomography-angiography-md-cta-of-coronary-artery-bypass-grafts-update-2017
#14
Florian Jungmann, Tilman Emrich, Peter Mildenberger, Anna Lena Emrich, Christoph Düber, K F Kreitner
Background Coronary artery bypass grafting (CABG) is still an important therapeutic approach in the treatment especially of advanced coronary artery disease. In this study, we elucidate the current role of multidetector computed tomography angiography (MD-CTA) in imaging patients after CABG surgery. Method This study is based on recent reports in the literature (2007 - 2016) on imaging of CABG using 64-slice MD-CT scanners and beyond. We included 13 reports that compared ECG-gated MD-CTA with conventional invasive coronary angiography (ICA) as the reference standard for the assessment of graft patency and for the detection of > 50 % stenoses...
November 3, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29099727/supplemental-computational-phantoms-to-estimate-out-of-field-absorbed-dose-in-photon-radiotherapy
#15
Kyle Joseph Gallagher, Jaad Tannous, Racile Nabha, Joelle Ann Feghali, Zeina Ayoub, Wassim T Jalbout, Bassem Youssef, Phillip J Taddei
The purpose of this study was to develop a straightforward method of supplementing patient anatomy and estimating out-of-field absorbed dose for a cohort of pediatric radiotherapy patients with limited recorded anatomy. A cohort of nine children, aged 2 to 14 years, who received three-dimensional conformal radiotherapy for low grade localized brain tumors (LBTs), were randomly selected for this study. The extents of these patients' computed tomography simulation image sets were cranial only. To approximate their missing anatomy, we supplemented the LBT patients' image sets with computed tomography images of patients in a previous study with larger extents of matched sex, height, and mass and for whom contours of organs at risk for radiogenic cancer had already been delineated...
November 3, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29097409/optimizing-image-quantification-for-lu-177-spect-ct-based-on-a-3d-printed-2-compartment-kidney-phantom
#16
Johannes Tran-Gia, Michael Lassmann
The aim of this work was to find an optimal setup for activity determination of Lu-177-based single photon emission computed tomography (SPECT) / computed tomography (CT) imaging reconstructed with two commercially available reconstructions (xSPECT Quant and Flash3D, Siemens Healthcare). For this purpose, 3D printed phantoms of different geometries were manufactured, different partial volume correction (PVC) methods were applied, and the accuracy of the activity determination was evaluated. METHODS: A 2-compartment kidney phantom (70% cortical and 30% medullary compartment), a sphere, and an ellipsoid of equal volumes were 3D printed, filled with Lu-177, and scanned with a SPECT/CT system...
November 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29096667/temporal-and-spatial-dose-distribution-of-radiation-pneumonitis-after-concurrent-radiochemotherapy-in-stage-iii-non-small-cell-cancer-patients
#17
Mohammed Alharbi, Stefan Janssen, Heiko Golpon, Michael Bremer, Christoph Henkenberens
BACKGROUND AND PURPOSE: Radiation pneumonitis (RP) is the most common subacute side effect after concurrent chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer. Several clinical and dose-volume (DV) parameters are associated with a distinct risk of symptomatic RP. The aim of this study was to assess the spatial dose distribution of the RP volume from first occurence to maximum volume expansion of RP. MATERIAL AND METHODS: Between 2007 and 2015, 732 patients with lung cancer were treated in an institution...
November 2, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29090963/stakeholder-research-priorities-for-smoking-cessation-interventions-within-lung-cancer-screening-programs-an-official-american-thoracic-society-research-statement
#18
Hasmeena Kathuria, Frank C Detterbeck, Joelle T Fathi, Kathleen Fennig, Michael K Gould, Denise G Jolicoeur, Stephanie R Land, Greta M Massetti, Peter J Mazzone, Gerard A Silvestri, Christopher G Slatore, Robert A Smith, Anil Vachani, Steven B Zeliadt, Renda Soylemez Wiener
RATIONALE: Smoking cessation counseling in conjunction with low-dose computed tomography (LDCT) lung cancer screening is recommended in multiple clinical practice guidelines. The best approach for integrating effective smoking cessation interventions within this setting is unknown. OBJECTIVES: To summarize evidence, identify research gaps, prioritize topics for future research, and propose standardized tools for use in conducting research on smoking cessation interventions within the LDCT lung cancer screening setting...
November 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29089148/is-the-coronary-artery-calcium-score-associated-with-acute-coronary-events-in-breast-cancer-patients-treated-with-radiotherapy
#19
Catharina T G Roos, Veerle A B van den Bogaard, Marcel J W Greuter, Rozemarijn Vliegenthart, Ewoud Schuit, Johannes A Langendijk, Arjen van der Schaaf, Anne P G Crijns, John H Maduro
BACKGROUND AND PURPOSE: The main objective of this study was to test whether pre-treatment coronary artery calcium (CAC) was associated with the cumulative incidence of acute coronary events (ACE) among breast cancer (BC) patients treated with postoperative radiotherapy (RT). MATERIAL AND METHODS: The study population consisted of 939 consecutive female BC patients treated with RT. The association between CAC and ACE was tested using Cox-proportional hazard models...
October 28, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29072629/a-score-based-approach-to-18-f-fdg-pet-images-as-a-tool-to-describe-metabolic-predictors-of-myocardial-doxorubicin-susceptibility
#20
Matteo Bauckneht, Silvia Morbelli, Francesco Fiz, Giulia Ferrarazzo, Roberta Piva, Alberto Nieri, Matteo Sarocchi, Paolo Spallarossa, Maria Elisa Canepari, Eleonora Arboscello, Andrea Bellodi, Massimo Massaia, Andrea Gallamini, Paolo Bruzzi, Cecilia Marini, Gianmario Sambuceti
PURPOSE: To verify the capability of (18)F-fluorodeoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) to identify patients at higher risk of developing doxorubicin (DXR)-induced cardiotoxicity, using a score-based image approach. METHODS: 36 patients underwent FDG-PET/CT. These patients had shown full remission after DXR-based chemotherapy for Hodgkin's disease (DXR dose: 40-50 mg/m² per cycle), and were retrospectively enrolled. Inclusion criteria implied the presence of both pre- and post-chemotherapy clinical evaluation encompassing electrocardiogram (ECG) and echocardiography...
October 26, 2017: Diagnostics
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