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https://www.readbyqxmd.com/read/29675260/one-too-many-diabetes-the-combination-of-hyperglycaemic-hyperosmolar-state-and-central-diabetes-insipidus
#1
Snezana Burmazovic, Christoph Henzen, Lukas Brander, Luca Cioccari
The combination of hyperosmolar hyperglycaemic state and central diabetes insipidus is unusual and poses unique diagnostic and therapeutic challenges for clinicians. In a patient with diabetes mellitus presenting with polyuria and polydipsia, poor glycaemic control is usually the first aetiology that is considered, and achieving glycaemic control remains the first course of action. However, severe hypernatraemia, hyperglycaemia and discordance between urine-specific gravity and urine osmolality suggest concurrent symptomatic diabetes insipidus...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29672249/urinary-tract-infection-by-strongyloides-stercoralis-a-case-report
#2
Nilo Manoel Pereira Vieira Barreto, Joelma Nascimento de Souza, Weslei Almeida Costa Araujo, Nadia Andrade Khouri, Ernesto Pereira de Oliveira, Márcia Cristina Aquino Teixeira, Neci Matos Soares
The objective of this study was to report a case of a hydronephrotic patient with Strongyloides stercoralis infection, with discharge of rhabditoid larva exclusively in urine. In 2013, a 72-yr-old, male patient, hypertensive, obese and diagnosed with hydronephrosis secondary to renal calculi, reported lumbar pain, polyuria, polaciuria and dysuria, as well as frequent urinary tract infections. The microscopic analysis of urine sediment showed the presence of S. stercoralis rabditoid larva. However, parasitological examinations by Baermann-Moraes, agar plate culture and spontaneous sedimentation, performed with 3 fecal samples on alternate days had negative results...
April 19, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29659365/-association-between-diabetic-ketoacidosis-and-acromegaly
#3
Paloma Ocampo, Juan Manuel Duarte, Ricardo Barcia, Cecilia Arévalo
Diabetes mellitus occurs in nearly 10% of patients with acromegaly and is secondary to insulin resistance caused by high levels of growth hormone. Diabetes ketoacidosis has been described as a rare complication of acromegaly, resulting from a relative insulin deficiency caused by growth hormone excess. We described the case of a 38 year-old man who presented to the emergency room with a 6-week history of polydipsia, polyuria, polyphagia and weight loss. He also had nausea, vomiting and abdominal pain from two days before admission...
2018: Medicina
https://www.readbyqxmd.com/read/29657879/primary-hyperparathyroidism-and-gougerot-disease
#4
Toumader Bouziane, Nadia Belmahi, Hanan El Ouahabi
Primary hyperparathyroidism (PHPT) is a common endocrine disorder caused by the overactivation of the parathyroid glands due to the autonomous production of the parathyroid hormone (PTH). The resultant hypercalcemia leads to a myriad of symptoms. Here we report the case of a 54-year-old female with a previous diagnosis of Gougerot disease, in whom clinical (diffuse bone pain, asthenia polydipsia, and polyuria) and laboratory features (calcium level, 3.1 mmol/L; phosphate level, 0.55 mmol/L; alkaline phosphatase level, 70 U/L; and intact PTH level, 1028...
March 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29643793/central-serous-chorioretinopathy-associated-with-desmopressin-nasal-spray-causality-or-unfortunate-association
#5
Nacima Kisma, Eleni Loukianou, Bishwanath Pal
Purpose: To describe the possible association between central serous chorioretinopathy (CSCR) and desmopressin use. Methods: The case histories of 2 middle-aged men with CSCR using desmopressin nasal spray were studied. Results: The diagnosis of CSCR was made on the basis of clinical features and ancillary testing (fluorescein angiography and optical coherence tomography). Both patients were using desmopressin nasal spray for polyuria when they developed the first ocular symptoms...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29642367/re-dietary-sodium-restriction-reduces-nocturnal-urine-volume-and-nocturnal-polyuria-index-in-renal-allograft-recipients-with-nocturnal-polyuria
#6
https://www.readbyqxmd.com/read/29609858/undetectable-high-density-lipoprotein-cholesterol-in-acute-malaria
#7
Ana Rakovac Tisdall, Vivion Edward Francis Crowley, Martin Andrew Crook
We report the case of a 39-year-old West African man in whom high-density lipoprotein cholesterol (HDL-C) was identified as undetectable at <0.08 mmol/L. Total cholesterol in the same sample was 2.85 mmol/L; triglycerides were only mildly elevated at 2.32 mmol/L. He was admitted with a 2-week history of polydipsia, polyuria, weight loss and hyperpyrexia. Dual malarial infection with Plasmodium ovale and falciparum was identified and attributed to a recent trip to Nigeria without chemoprophylaxis. Also, he was diagnosed with diabetes mellitus with random hyperglycemia of 39 mmol/L but no ketonemia...
March 9, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29603801/bladder-overdistension-with-polyuria-in-a-hypertensive-rat-model
#8
Monica Velasquez Flores, Abubakr H Mossa, Philippe Cammisotto, Lysanne Campeau
AIMS: Polyuria can lead to progressive chronic bladder overdistension. The impact of polyuria on the bladder has been extensively studied in settings of either diabetes or sucrose diuresis in animals. The goal of this study was to investigate the outcomes of polyuria in a hypertension setting. MATERIALS AND METHODS: Male Dahl/SS rats, a hypertension model, received a high-salt or normal diet for 6 weeks. Twenty-four-hour water intake, micturition patterns, and blood pressures were recorded biweekly...
March 31, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29594432/novel-and-recurrent-variants-in-avpr2-in-19-families-with-x-linked-congenital-nephrogenic-diabetes-insipidus
#9
Shivani Joshi, Helene Kvistgaard, Konstantinos Kamperis, Mia Færch, Søren Hagstrøm, Niels Gregersen, Søren Rittig, Jane Hvarregaard Christensen
Congenital nephrogenic diabetes insipidus (CNDI) is characterized by the reduced ability of renal collecting duct cells to reabsorb water in response to the antidiuretic effect of vasopressin. Chronic polyuria and polydipsia are the hallmarks of the disease. Approximately 90% of all patients with CNDI have X-linked inherited disease caused by variants in the arginine vasopressin receptor 2 (AVPR2) gene. We present genetic findings in 34 individuals from 19 kindreds including one or more family members with CNDI...
March 28, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29594084/transient-antenatal-bartter-s-syndrome-a-case-report
#10
Michelle Meyer, Margarita Berrios, Christina Lo
Antenatal Bartter's syndrome is a rare inherited disorder characterized by fetal polyhydramnios and polyuria that is usually detected between 24 and 30 weeks of gestation. However, a rare, severe, but transient form of antenatal Bartter's syndrome due to an x-linked melanoma-associated antigen D2 (MAGED2) mutation has recently been described. This transient type results in the earlier onset of severe polyhydramnios and preterm birth, but spontaneously resolves postnatally. Here, we present a case of a 29-week gestation male born to a mother with severe polyhydramnios, who was subsequently found to have a novel mutation for MAGED2 not previously reported...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29592526/combination-exposure-of-melamine-and-cyanuric-acid-is-associated-with-polyuria-and-activation-of-nlrp3-inflammasome-in-rats
#11
Feifei Wang, Qiaojuan Liu, Lizi Jin, Shan Hu, Renfei Luo, Mengke Han, Yonggong Zhai, Weidong Wang, Chunling Li
The molecular mechanism of melamine-induced renal toxicity have not been fully understood. The purpose of the study aimed to investigate whether melamine and cyanuric acid induced NLRP3 inflammasome activation in the kidney, which may contribute to abnormal water and sodium handling in a rat model. Wistar rats were received melamine (Mel, 200 mg/kg BW/day), cyanuric acid (CA, 200 mg/kg BW/day), or Mel plus CA (Mel+CA, 100 mg/kg BW/day, each) for two weeks. Mel+CA caused damaged tubular epithelial structure and organelles, dilated tubular lumen, and inflammatory responses...
March 28, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29572168/lymphocytic-hypophysitis-secondary-to-ruptured-rathke-s-cleft-cyst-case-report-and-literature-review
#12
Chengxian Yang, Huanwen Wu, Xinjie Bao, Renzhi Wang
BACKGROUND: Lymphocytic hypophysitis (LH) is a rare inflammatory lesion in sellar region. LH secondary to ruptured Rathke's cleft cyst (RCC) is even more rarely observed according to published case reports. The clinical characteristics, treatment strategies and prognosis of such lesions remain elusive. CASE DESCRIPTION: A 58-year-old Chinese woman was admitted to our hospital complaining of initial intermittent headache for 3 years and new development of polydipsia, polyuria, and binocular visual acuity decline for recent 4 months...
March 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29568987/furosemide-induced-tubular-dysfunction-responding-to-prostaglandin-synthesis-inhibitor-therapy-in-a-child-with-nephrotic-syndrome
#13
T Harish Varma, Ashish Sharma, S Santhiya, Lesa Dawman, Karalanglin Tiewsoh
Furosemide is one of the most common drug used to treat anasarca in childhood nephrotic syndrome. It has minimal side effects on short-term usage, but prolonged use can result in polyuria, hypokalemia and metabolic alkalosis. This pseudo-bartter complication can be treated by discontinuation of the drug with adequate potassium replacement. We report a child who was given furosemide for 20 days elsewhere to treat the edema due to nephrotic syndrome and then presented to us with bartter-like syndrome. Furosemide was discontinued and potassium replacement was initiated...
March 22, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29568696/aplastic-anemia-secondary-to-nivolumab-and-ipilimumab-in-a-patient-with-metastatic-melanoma-a-case-report
#14
D E Meyers, W F Hill, A Suo, V Jimenez-Zepeda, T Cheng, N A Nixon
Background: Immune checkpoint blockade (ICB) is becoming an increasingly prevalent strategy in the clinical realm of cancer therapeutics. With more patients being administered ICB for a host of tumor types, the scope of adverse events associated with these drugs will likely grow. Here we report a case of aplastic anemia (AA) in a patient with metastatic melanoma secondary to dual ICB therapy. To our knowledge, this is only the second case of AA secondary to dual ICB in the literature, and the first to have a positive patient outcome...
2018: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29563012/diabetes-in-childhood-and-adolescence
#15
Ralph Ziegler, Andreas Neu
BACKGROUND: The incidence of type 1 diabetes mellitus in childhood and adolescence is steadily rising and now stands at 22.9 new cases per year per 100 000 persons up to age 15. METHODS: This review is based on pertinent publications retrieved by a selective literature search, with special attention to the current German S3 guideline on diabetes in childhood and adolescence. RESULTS: Polydipsia, polyuria, and weight loss are the characteristic presenting symptoms of diabetes mellitus...
March 2, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29558216/fanconi-syndrome-in-irish-wolfhound-siblings
#16
Nick X Bommer, Serena E Brownlie, Linda R Morrison, Marge L Chandler, James W Simpson
Three juvenile male Irish wolfhound littermates presented with marked polyuria and polydipsia. The four female siblings were apparently unaffected. Diagnostic testing revealed glucosuria with normoglycemia, generalized aminoaciduria, hypokalemia and metabolic acidosis consistent with Fanconi syndrome. Renal ultrasonographic and histologic findings are presented. Cases were managed with a supplementation regimen based on a treatment protocol for Fanconi syndrome in basenjis. These dogs did not have angular limb deformities as documented previously in juvenile canine siblings with Fanconi syndrome...
March 20, 2018: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29553830/medullary-thick-ascending-limb-impairment-in-the-gla-tm-tg-cag-a4galt-fabry-model-mice
#17
Hiroki Maruyama, Atsumi Taguchi, Yuji Nishikawa, Chu Guili, Mariko Mikame, Masaaki Nameta, Yutaka Yamaguchi, Mitsuhiro Ueno, Naofumi Imai, Yumi Ito, Takahiko Nakagawa, Ichiei Narita, Satoshi Ishii
A main feature of Fabry disease is nephropathy, with polyuria an early manifestation; however, the mechanism that underlies polyuria and affected tubules is unknown. To increase globotriaosylceramide (Gb3) levels, we previously crossbred asymptomatic Glatm mice with transgenic mice that expressed human Gb3 synthase (A4GALT) and generated the Glatm Tg(CAG-A4GALT) symptomatic Fabry model mice. Additional analyses revealed that these mice exhibit polyuria and renal dysfunction without remarkable glomerular damage...
March 19, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29543730/cadmium-nephrotoxicity-is-associated-with-altered-microrna-expression-in-the-rat-renal-cortex
#18
Michael J Fay, Lauren A C Alt, Dominika Ryba, Ribhi Salamah, Ryan Peach, Alexander Papaeliou, Sabina Zawadzka, Andrew Weiss, Nil Patel, Asad Rahman, Zyaria Stubbs-Russell, Peter C Lamar, Joshua R Edwards, Walter C Prozialeck
Cadmium (Cd) is a nephrotoxic environmental pollutant that causes a generalized dysfunction of the proximal tubule characterized by polyuria and proteinuria. Even though the effects of Cd on the kidney have been well-characterized, the molecular mechanisms underlying these effects have not been fully elucidated. MicroRNAs (miRNAs) are small non-coding RNAs that regulate cellular and physiologic function by modulating gene expression at the post-transcriptional level. The goal of the present study was to determine if Cd affects renal cortex miRNA expression in a well-established animal model of Cd-induced kidney injury...
March 15, 2018: Toxics
https://www.readbyqxmd.com/read/29541862/do-independent-geriatric-outpatients-with-nocturnal-polyuria-profit-from-desmopressin
#19
W Weinrebe, S Käbe-Frisch, I Füsgen, M Karaman, E Johannsdottir, S Rupp
OBJECTIVE: To compare the efficacy of desmopressin and placebo in independent geriatric outpatients with nocturnal polyuria (NP). METHODS: A prospective, randomized, single-center, national, double blind, placebo-controlled, fixed-dose, parallel group comparative trial was carried out. The study included 110 geriatric outpatients, 55 patients per treatment group using desmopressin acetate nasal spray (strength: 0.1 mg/ml) once daily of 10 μg/spray blast or placebo...
March 14, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29531931/thrombotic-thrombocytopenic-purpura-in-a-child-with-diabetic-ketoacidosis
#20
Neda Mostofizadeh, Serajaddin Arefnia, Mahin Hashemipour, Elham Hashemi Dehkordi
Thrombotic thrombocytopenic purpura (TTP) secondary to diabetic ketoacidosis has been rarely reported and is considered as a rare complication. If left untreated, this condition could be life threatening with considerable morbidity and mortality. Herein, we report a 6-year-old girl with reduced consciousness and respiratory distress with a history of polydipsia and polyuria in the 2 weeks before hospitalization. The patient was initially diagnosed as diabetic ketoacidosis based on clinical and laboratory findings and treated accordingly...
2018: Advanced Biomedical Research
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