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https://www.readbyqxmd.com/read/29345157/evaluation-of-serum-cysteine-rich-protein-61-levels-in-patients-with-coronary-artery-disease
#1
Jingang Deng, Xiaoxian Qian, Jianping Li, Yanghua Li, Yang Li, Yijun Luo
AIM: The aim is to evaluate serum cysteine-rich protein 61 (Cyr61) levels in patients with coronary artery disease (CAD). PATIENTS & METHODS: Serum Cyr61 levels were measured in 180 patients with CAD and 74 participants without CAD. RESULTS: Serum Cyr61 levels were significantly higher in CAD patients. Patients with acute coronary syndrome showed significantly higher Cyr61 than those with stable angina pectoris. Serum Cyr61 levels in complex lesion group were significantly higher...
January 18, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29339697/the-value-of-real-time-myocardial-contrast-echocardiography-for-detecting-coronary-microcirculation-function-in-coronary-artery-disease-patients
#2
Lulu Sun, Zilong Wang, Tongda Xu, Defeng Pan, Li Liang, Ji Hao, Xiaoping Wang, Dongye Li
OBJECTIVE: The aim of this study was to evaluate the value of real-time myocardial contrast echocardiography (RT-MCE) for detecting coronary microcirculation (CM) function in coronary artery disease (CAD) patients. METHODS: Sixty-five consecutive patients were divided into CAD (n=52) and no-CAD (n=13) groups using coronary angiography (CAG). All patients underwent RT-MCE at rest and CAG within 1 week after RT-MCE. The ventricular segments in CAD patients were divided semi-quantitatively into ischemic and non-ischemic myocardial groups based on RT-MCE images...
January 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29331103/comparison-of-coronary-risk-factors-and-angiographic-findings-in-younger-and-older-patients-with-significant-coronary-artery-disease
#3
Mohammad Parsa Mahjoob, Soheila Sadeghi, Hamide Falahaty Khanaman, Mohammadreza Naderian, Isa Khaheshi
BACKGROUND: Coronary artery disease (CAD) is uncommon among young adults and may have certain characteristics that are different from those in older patients. The aim of the current study was to determine the risk factors of CAD, important laboratory data and angiographic findings in young patients with CAD and to compare them with the old patients. METHODS: Patients with typical chest pain whose CAD was confirmed by coronary angiography were included in the study...
December 20, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29321131/efficacy-of-ranolazine-in-patients-with-symptomatic-hypertrophic-cardiomyopathy-the-restyle-hcm-randomized-double-blind-placebo-controlled-study
#4
Iacopo Olivotto, Paolo G Camici, Piera Angelica Merlini, Claudio Rapezzi, Monica Patten, Vicent Climent, Gianfranco Sinagra, Benedetta Tomberli, Francisco Marin, Philipp Ehlermann, Lars S Maier, Alessandra Fornaro, Claudius Jacobshagen, Antonello Ganau, Luciano Moretti, Antonio Hernandez Madrid, Raffaele Coppini, Giorgio Reggiardo, Corrado Poggesi, Francesco Fattirolli, Luiz Belardinelli, Gianfranco Gensini, Alessandro Mugelli
BACKGROUND: The late sodium current inhibitor ranolazine reverses the main electrophysiological and mechanical abnormalities of human hypertrophic cardiomyopathy (HCM) cardiomyocytes in vitro, suggesting potential clinical benefit. We aimed to assess the effect of ranolazine on functional capacity, symptomatic status, diastolic function, and arrhythmias in HCM. METHODS AND RESULTS: In this multicenter, double-blind, phase 2 study, 80 adult patients with nonobstructive HCM (age 53±14 years, 34 women) were randomly assigned to placebo (n=40) or ranolazine 1000 mg bid (n=40) for 5 months...
January 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29316562/mir-126-in-peripheral-blood-mononuclear-cells-negatively-correlates-with-risk-and-severity-and-is-associated-with-inflammatory-cytokines-as-well-as-intercellular-adhesion-molecule-1-in-patients-with-coronary-artery-disease
#5
Huiliang Wu, Jing Zhang
OBJECTIVES: The aim of this study was to evaluate the association of miR-126 with risk and severity of coronary artery disease (CAD) as well as its correlation with inflammatory cytokines and endothelial related proteins. METHODS: In total, 215 patients suspected of CAD who underwent coronary angiography were enrolled in this case control study and were divided into a CAD group (n = 119) and control group (n = 96). miR-126 relative expression was assessed by real-time polymerase chain reaction...
January 10, 2018: Cardiology
https://www.readbyqxmd.com/read/29297177/low-cpne3-expression-is-associated-with-risk-of-acute-myocardial-infarction-a-feasible-genetic-marker-of-acute-myocardial-infarction-in-patients-with-stable-coronary-artery-disease
#6
Buchuan Tan, Long Liu, Yushuang Yang, Qian Liu, Liping Yang, Fanbo Meng
BACKGROUND: Gene COPINE III may be related to a phosphoprotein with intrinsic kinase activity and belongs to an unconventional kinase family. The CPNE3 gene may be used as a biomarker for assessment of occurrence and prognosis of various tumors. METHODS: Peripheral blood was collected from 87 stable CAD patients and 91 AMI patients. Real-time quantitative PCR test and the western blot method were adopted to measure expression quantity of CPNE3 gene at the mRNA level and the protein level...
January 3, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29285294/usefulness-of-plasma-matrix-metalloproteinase-9-levels-in-prediction-of-in-hospital-mortality-in-patients-who-received-emergent-percutaneous-coronary-artery-intervention-following-myocardial-infarction
#7
Jia-Jun Zhu, Qian Zhao, Hui-Juan Qu, Xiao-Mei Li, Qing-Jie Chen, Fen Liu, Bang-Dang Chen, Yi-Ning Yang
The aim of the present study was to investigate the predictive value of the plasma matrix metalloproteinase-9 (MMP-9) level at admission for in-hospital mortality in patients who received emergency percutaneous coronary intervention (PCI) following AMI. A single blood sample was collected at admission from 155 consecutive AMI patients who underwent emergent PCI. The plasma levels of MMP-9 value (528.9±191.6 ng/ml) were significantly higher in the patients who died (n=24) than in the survivors (385.4±236.0 ng/ml) during 14 days of hospitalization (P=0...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29245302/mthfr-c677t-gene-polymorphism-and-the-severity-of-coronary-lesions-in-acute-coronary-syndrome
#8
Miao-Nan Li, Hong-Ju Wang, Ning-Ru Zhang, Ling Xuan, Xiao-Jun Shi, Tong Zhou, Bin Chen, Jun Zhang, Hui Li
The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, circulating levels of homocysteine (Hcy), and the severity of coronary lesion in patients with acute coronary syndrome (ACS) remains unknown.Consecutive ACS patients were included. MTHFR C677T polymorphisms were determined via amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Gensini scores were used to evaluate the severity of coronary lesions.Three hundred ten ACS patients were included, and grouped according to the MTHFR C677T polymorphism variant: CC (n = 78, 25...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29226890/relationship-between-the-extent-of-coronary-artery-disease-and-in-stent-restenosis-in-patients-with-acute-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#9
Erkan Yıldırım, Murat Çelik, Uygar Çağdaş Yüksel, Barış Buğan, Yalçın Gökoğlan, Suat Görmel, Salim Yaşar, Mustafa Koklu, Atila İyisoy, Cem Barçın
OBJECTIVE: The pathophysiological mechanism of in-stent restenosis (ISR) is different from atherosclerosis of native coronary arteries. The aim of this study was to evaluate the relationship between ISR and the extent of coronary artery disease (CAD), and to identify other risk factors associated with ISR in ST-segment elevation myocardial infarction (STEMI) patients. METHODS: A total of 372 consecutive patients presenting with first acute STEMI who were successfully treated with primary percutaneous coronary intervention within 12 hours from the onset of symptoms and who had an angiographic follow-up at 3 months were included in the study...
December 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29184509/parp-1-variant-rs1136410-confers-protection-against-coronary-artery-disease-in-a-chinese-han-population-a-two-stage-case-control-study-involving-5643-subjects
#10
Xue-Bin Wang, Ning-Hua Cui, Shuai Zhang, Shu-Ren Guo, Ze-Jin Liu, Liang Ming
Inhibition of poly(ADP-ribose) polymerase (PARP) may protect against coronary artery disease (CAD) in animal models, and rs1136410, a non-synonymous single nucleotide polymorphism (SNP) in PARP-1, has a potential impact on PARP activities in vitro. This two-stage case-control study, involving 2803 CAD patients and 2840 controls, aimed to investigate the associations of PARP-1 rs1136410 with CAD development, lipid levels, PARP activities, 8-hydroxy-2'-dexyguanosine (8-OHdG), and interleukin (IL)-6 levels in a Chinese Han population...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29179498/acat-1-gene-polymorphism-is-associated-with-increased-susceptibility-to-coronary-artery-disease-in-chinese-han-population-a-case-control-study
#11
Yong-Tao Wang, Ying-Hong Wang, Yi-Tong Ma, Zhen-Yan Fu, Yi-Ning Yang, Xiang Ma, Xiao-Mei Li, Dilare Adi, Fen Liu, Bang-Dang Chen
Several studies suggest an important role of Acyl-CoA: cholesterol acyltransferase-1(ACAT-1) in the development of atherosclerosis. The aim of present study was to investigate whether there exists a possible correlation between genetic variations in ACAT-1 genes and coronary artery disease (CAD) risk. Four polymorphisms (rs1044925, rs11545566, rs12121758 and rs10913733) were finally selected and genotyped in 750 CAD patients and 580 health controls, using the improved multiplex ligation detection reaction (iMLDR) method...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29174254/-correlation-of-red-blood-cell-distribution-width-with-the-severity-of-coronary-artery-disease-a-single-center-study
#12
Praveen Nagula, Suneetha Karumuri, Adikesava Naidu Otikunta, Subba Reddy Venkata Yerrabandi
OBJECTIVE: Coronary Artery Disease (CAD) is the leading cause of morbidity and mortality all around the world. We evaluated the correlation of Red blood cell Distribution Width (RDW) with the severity of lesion on coronary angiography as assessed by Modified Gensini score (MGS) in CAD patients. METHODS: A total of 576 consecutive patients admitted in Department of Cardiology over a period of one year, who underwent coronary angiography after diagnosis of CAD or presence of angina like chest pain and/or positive treadmill test were enrolled in the study (August 2014-May 2015)...
November 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29113395/association-between-fibrinogen-level-and-the-severity-of-coronary-stenosis-in-418-male-patients-with-myocardial-infarction-younger-than-35-years-old
#13
Xiong-Yi Gao, Bing-Yang Zhou, Min-Zhou Zhang, Xi Zhao, Ping Qing, Cheng-Gang Zhu, Na-Qiong Wu, Yuan-Lin Guo, Ying Gao, Xiao-Lin Li, Yao Wang, Geng Liu, Qian Dong, Li-Heng Guo, Jian-Jun Li
Fibrinogen (Fib) is a useful marker for predicting the severity of coronary artery disease (CAD) in adult population. However, whether Fib can be a predictor for the presence and severity of CAD in very young MI patients (≤35 years old) remains to be determined. A total of 418 males from 61,863 patients with MI who were under 35 years old were sequentially recruited in our study. The patients were divided into two main groups and three subgroups according to coronary angiograph and Gensini score (GS) system: no coronary artery stenosis (group A), the results of the coronary artery stenosis (group B); low GS, intermediate GS and high GS...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29089340/genetic-variation-at-the-adamts7-locus-is-associated-with-reduced-severity-of-coronary-artery-disease
#14
Kenneth Chan, Xiangyuan Pu, Pratik Sandesara, Robin N Poston, Iain A Simpson, Arshed A Quyyumi, Shu Ye, Riyaz S Patel
BACKGROUND: Genome-wide association studies identified ADAMTS7 as a risk locus for coronary artery disease (CAD). Functional studies suggest that ADAMTS7 may promote cellular processes in atherosclerosis. We sought to examine the association between genetic variation at ADAMTS7 and measures of atherosclerosis using histological, angiographic, and clinical outcomes data. METHODS AND RESULTS: The lead CAD-associated single-nucleotide polymorphism rs3825807 at the ADAMTS7 locus was genotyped...
October 31, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29079813/postprandial-blood-glucose-outweighs-fasting-blood-glucose-and-hba1c-in-screening-coronary-heart-disease
#15
Jingjing Jiang, Lin Zhao, Liu Lin, Minghui Gui, Qiqige Aleteng, Bingjie Wu, Shanshan Wang, Baishen Pan, Yan Ling, Xin Gao
The objective of the present study is to assess the performance of fasting blood glucose (FBG), postprandial blood glucose (PBG), and glycated hemoglobin (HbA1c) as screening for coronary heart disease (CHD) in an inpatient population undergoing coronary angiography. 1852 consecutive patients scheduled for coronary angiography were classified into Normal Glucose Tolerance (NGT), Impaired Glucose Regulation (IGR), and diabetes, based on FBG, PBG, and HbA1c. Correlations of Gensini score with glucose metabolism and insulin resistance were analyzed...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050745/a-spectrum-of-retinal-vasculature-measures-and-coronary-artery-disease
#16
Sarah B Wang, Paul Mitchell, Gerald Liew, Tien Yin Wong, Kevin Phan, Aravinda Thiagalingam, Nichole Joachim, George Burlutsky, Bamini Gopinath
BACKGROUND AND AIMS: We aimed to comprehensively describe a spectrum of retinal vessel measures including fractal dimension (Df) and their associations with indices of coronary artery disease (CAD) extent and severity, as well as hypertension and diabetes. METHODS: The Australian Heart Eye Study (AHES) is an observational study that surveyed 1680 participants presenting to a tertiary referral hospital for the evaluation of potential CAD by coronary angiography. A range of newer retinal vessel geometric measures (Df, curvature tortuosity, and branching angle) were quantified from retinal photographs using semi-automated software, the Singapore 'I' Vessel Assessment (SIVA) tool...
October 10, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29032450/association-between-coronary-artery-disease-severity-and-overactive-bladder-in-geriatric-patients
#17
Muhammet Fatih Kilinc, Erdogan Yasar, Halil Ibrahim Aydin, Yildiray Yildiz, Omer Gokhan Doluoglu
PURPOSE: To investigate the association between overactive bladder (OAB) and coronary artery disease (CAD) as demonstrated on coronary angiography in patients > 65 years. METHODS: The patients who were > 65 years completed an OAB-V8 form before undergoing coronary angiography at a tertiary care hospital. The presence of OAB was documented using the self-administered OAB-V8 questionnaire. Formal stratification of the coronary vessels plaque burden was assessed by calculation of a Gensini score for each patient...
October 14, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28979897/genome-wide-association-analysis-for-severity-of-coronary-artery-disease-using-the-gensini-scoring-system
#18
Tanja Zeller, Moritz Seiffert, Christian Müller, Markus Scholz, Anna Schäffer, Francisco Ojeda, Heinz Drexel, Axel Mündlein, Marcus E Kleber, Winfried März, Christoph Sinning, Fabian J Brunner, Christoph Waldeyer, Till Keller, Christoph H Saely, Karsten Sydow, Joachim Thiery, Daniel Teupser, Stefan Blankenberg, Renate Schnabel
Coronary artery disease (CAD) has a complex etiology involving numerous environmental and genetic factors of disease risk. To date, the genetic 9p21 locus represents the most robust genetic finding for prevalent and incident CAD. However, limited information is available on the genetic background of the severity and distribution of CAD. CAD manifests itself as stable CAD or acute coronary syndrome. The Gensini score quantifies the extent CAD but requires coronary angiography. Here, we aimed to identify novel genetic variants associated with Gensini score severity and distribution of CAD...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28977790/coronary-artery-diameter-is-inversely-associated-with-the-severity-of-coronary-lesions-in-patients-undergoing-coronary-angiography
#19
Fang-Fang Zhou, Yun-Hai Liu, Peng-Cheng Ge, Zhao-Hong Chen, Xiao-Qing Ding, Jie-Yin Liu, Qiao-Wei Jia, Feng-Hui An, Li-Hua Li, Lian-Sheng Wang, Wen-Zhu Ma, Zhi-Jian Yang, En-Zhi Jia
BACKGROUND: The diameters of the coronary arteries have been suggested to be a potential predictor of coronary artery disease (CAD). However, whether the diameters of the coronary arteries are associated with the coronary lesion severity on angiography has not been determined. METHODS: One hundred sixty-seven consecutive adult patients (109 men and 58 women) aged 31-84 years who underwent coronary angiography for suspected or known CAD were enrolled. The known catheter tip diameter was used as the calibration to measure the diameters of coronary arteries, and the severity of coronary lesions was evaluated with the vessel score and Gensini score...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28965111/impact-of-the-chronic-repetitive-leg-ischemia-on-left-ventricular-function-and-severity-of-coronary-atherosclerosis-in-patients-with-acute-coronary-syndrome
#20
Mutlu Gungor, Erkan Yildirim
OBJECTIVE: The purpose of this study was to assess the impact of the concomitant presence of the peripheral arterial disease (PAD) on left ventricular function in patients with coronary artery disease (CAD) presented with acute coronary syndrome (ACS). SUBJECTS AND METHODS: The medical records of the patients who were referred to Ankara Bayindir Hospital, Ankara, Turkey due to the first episode of ACS were reviewed. Patients with concomitant PAD and CAD (Group1) were compared with those who had CAD alone (Group 2)...
October 1, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
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