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https://www.readbyqxmd.com/read/28808203/clinical-application-of-simultaneous-detection-of-cystatin-c-cathepsin-s-and-il-1-in-classification-of-coronary-artery-disease
#1
Ling Yan, Shuang Ding, Bing Gu, Ping Ma
Cystatin C, cathepsin S, and IL-1 are three important biomarkers of atherosclerosis. Previous studies emphasized the relationship between individual biomarkers in coronary artery disease (CAD) patients and severity of atherosclerostic lesions of the coronary arteries, while combined cystatin C, cathepsin S, and IL-1 have not been reported for clinical classification of CAD. We aimed to establish a link between cystatin C, cathepsin S, IL-1 and CAD in this cohort study. Totally 112 subjects were enrolled and divided into the stable angina pectoris group, the unstable angina pectoris group and the acute myocardial infarction (AMI) groups, and 50 healthy adults served as controls...
July 13, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28806974/association-of-plasma-fatty-acid-alteration-with-the-severity-of-coronary-artery-disease-lesions-in-tunisian-patients
#2
Samia Hadj Ahmed, Nadia Kaoubaa, Wafa Kharroubi, Amira Zarrouk, Mohamed Fadhel Najjar, Fathi Batbout, Habib Gamra, Gerard Lizard, Mohamed Hammami
BACKGROUND: Some factors related to diet are known to be involved in the progression of atherosclerosis in humans. METHODS: The relationship between plasma fatty acid (FA) levels and the severity of coronary artery disease (CAD), evaluated by Gensini score (GS), was investigated in CAD Tunisian patients compared to controls. Lipid profiles were analyzed, GS was calculated in CAD and non-CAD patients and compared to controls. RESULTS: CAD patients showed an alteration of conventional lipid parameters...
August 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28795637/do-angptl-4-and-galectin-3-reflect-the-severity-of-coronary-artery-disease
#3
Luxitaa Goenka, Melvin George, Vishakha Singh, Amrita Jena, Deepika Seshadri, Vasanth Karunakaran, Dhandapani Vellala Elumalai, Jamuna Rani, Ilango Kaliappan
BACKGROUND: Coronary artery disease (CAD) is one of the leading causes of mortality and morbidity worldwide. We thereby sought to investigate whether the biomarkers, angiopoietin-like 4 (ANGPTL-4) and galectin-3, reflect the severity of CAD. METHODS: Patients were screened based on inclusion/exclusion criteria and written informed consent was obtained from the patients. Serum ANGPTL-4 and galectin-3 was quantified using enzyme-linked immunosorbent assay (ELISA) and correlated with the Global Registry of Acute Coronary Events (GRACE) and GENSINI score using Spearman's rank correlation coefficient and multivariate analysis...
August 1, 2017: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/28794636/helicobacter-pylori-infection-and-severity-of-coronary-atherosclerosis-in-patients-with-chronic-coronary-artery-disease
#4
Anita Jukic, Dorotea Bozic, Dusko Kardum, Tina Becic, Bruno Luksic, Mislav Vrsalovic, Marko Ljubkovic, Damir Fabijanic
AIM: Controversy exists concerning the relation between Helicobacter pylori (HP) infection and coronary artery disease (CAD). We aimed to examine the relationship between HP infection and severity of coronary atherosclerosis in patients with chronic CAD. PATIENTS AND METHODS: A total of 150 patients (109 [73%] men; mean age 62.61±10.23 years) scheduled for coronary artery bypass grafting surgery were consecutively enrolled in the cross-sectional study. According to rapid urease test and/or gastric biopsy samples stained with hematoxylin and eosin and according to Giemsa, patients were classified as HP positive (n=87; 58%) or HP negative (n=63; 42%)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28789919/identification-of-long-and-very-long-chain-fatty-acids-plasmalogen-c16-0-and-phytanic-acid-as-new-lipid-biomarkers-in-tunisian-coronary-artery-disease-patients
#5
Samia Hadj Ahmed, Nadia Koubaa, Wafa Kharroubi, Amira Zarrouk, Amira Mnari, Fethi Batbout, Habib Gamra, Sonia Hammami, Gérard Lizard, Mohamed Hammami
Long and very long chain fatty acids (LCFAs and VLCFAs) may play an active role in coronary artery diseases (CAD) etiology. Our aim was to evaluate the associations between LCPUFAs (C20:4n-6; C20:5n-3 and C22:6n-3) and VLCSFAs (C22:0, C24:0; and C26:0), as well as markers of peroxisomal integrity evaluated by phytanic acid and plasmalogen-C16:0 (PL-C16:0) in addition to the markers of lipid peroxidation (malondialdehyde [MDA] and conjugated dienes [CD]) and inflammation (high sensitivity C-reactive protein [hs-CRP]) with vascular severity evaluated by Gensini score in order to determine their possible effects on CAD in Tunisian population...
August 5, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28781261/-combined-markers-of-initial-stages-of-coronary-atherosclerosis
#6
N G Gumanova, M V Klimushina, N E Gavrilova, V A Metelskaya
Abnormalities in energy metabolism and endothelial dysfunction contribute to signaling processes associated with atherogenesis. The goal of our study was to develop diagnostic tests based on endothelial functional markers and adiponectin to differentiate early stages of coronary lesions during atherogenesis. The cohort included male and female patients from 25 to 86 years of age. All subjects underwent coronary angiography and severity of coronary lesions was quantified by the Gensini score that assigns points depending on location and extent of the lesions...
May 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/28776137/ethnic-differences-in-the-risk-factors-and-severity-of-coronary-artery-disease-a-patient-based-study-in-iran
#7
Seyed Hesameddin Abbasi, Örjan Sundin, Arash Jalali, Joaquim Soares, Gloria Macassa
BACKGROUND: Diverse ethnic groups may differ regarding the risk factors and severity of coronary artery disease (CAD). This study sought to assess the association between ethnicity and CAD risk and severity in six major Iranian ethnic groups. METHODS: In this study, 20,165 documented coronary artery disease patients who underwent coronary angiography at a tertiary referral heart center were recruited. The demographic, laboratory, clinical, and risk factor data of all the patients were retrieved...
August 3, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28732653/sestrins-increase-in-patients-with-coronary-artery-disease-and-associate-with-the-severity-of-coronary-stenosis
#8
Jing Ye, Menglong Wang, Yao Xu, Jianfang Liu, Huimin Jiang, Zhen Wang, Yingzhong Lin, Jun Wan
BACKGROUND: Sestrins (Sesns) family, which including three members Sesn1, Sesn2 and Sesn3, is known as stress-inducible proteins and participate in multiple diseases via regulating oxidative stress, inflammatory response and cell apoptosis. The present study aimed to investigate the plasma levels and the clinical significance of Sesns in patients with coronary artery disease (CAD). METHODS: In the case-control study, 119 CAD patients, including stable angina pectoris (SAP, n=44), unstable angina pectoris (UAP, n=41) and acute myocardial infarction (AMI, n=29) were included...
July 18, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28682149/glycosylated-haemoglobin-and-coronary-atherosclerosis-in-non-diabetic-patients-is-it-a-prognostic-factor
#9
Reza Ajudani, Mohammad Saeid Rezaee-Zavareh, Hamidreza Karimi-Sari, Mahdi Safiabadi, Fardin Dolatimehr, Mohammadreza Okhovatian, Mahdi Ramezani-Binabaj, Bahram Pishgoo
BACKGROUND: Some studies aimed to evaluate the relationship between HbA1c and coronary artery disease (CAD). However, it is well known that long-term glycometabolic disorders put the heart at risk for CAD. Considering the inconsistencies between previous studies, this study aimed to investigate the relationship between HbA1c and coronary artery atherosclerosis. METHODS: A cross-sectional study was conducted on 411 non-diabetic patients who underwent their first coronary angiography between November 2013 and December 2014 in Baqiyatallah Hospital...
July 6, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28645074/relationship-between-inter-arm-blood-pressure-difference-and-severity-of-coronary-atherosclerosis
#10
Se-Jun Park, Jung-Woo Son, Sang-Min Park, Hyun-Hee Choi, Kyung-Soon Hong
BACKGROUND AND AIMS: A greater inter-arm blood pressure difference (IABPD) is associated with atherosclerosis, but its association with coronary artery disease is unknown. We investigated the relationship between IABPD and coronary atherosclerosis. METHODS: We retrospectively reviewed blood pressure (BP) data that was measured simultaneously in both arms of patients who underwent initial coronary angiography. Coronary atherosclerosis was assessed using the Gensini score, based on quantitative coronary angiography findings...
June 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28644146/association-between-fibrinogen-level-and-the-severity-of-coronary-stenosis-in-418-male-patients-with-myocardial-infarction-younger-than-35-years-old
#11
Xiong-Yi Gao, Bing-Yang Zhou, Min-Zhou Zhang, Xi Zhao, Ping Qing, Cheng-Gang Zhu, Na-Qiong Wu, Yuan-Lin Guo, Ying Gao, Xiao-Lin Li, Yao Wang, Geng Liu, Qian Dong, Li-Heng Guo, Jian-Jun Li
Fibrinogen (Fib) is a useful marker for predicting the severity of coronary artery disease (CAD) in adult population. However, whether Fib can be a predictor for the presence and severity of CAD in very young MI patients (≤35 years old) remains to be determined. A total of 418 males from 61,863 patients with MI who were under 35 years old were sequentially recruited in our study. The patients were divided into two main groups and three subgroups according to coronary angiograph and Gensini score (GS) system: no coronary artery stenosis (group A), the results of the coronary artery stenosis (group B); low GS, intermediate GS and high GS...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28642975/association-of-bone-metabolism-markers-with-coronary-atherosclerosis-and-coronary-artery-disease-in-postmenopausal-women
#12
Yan Ling, Zhen Wang, Bingjie Wu, Xin Gao
This study aimed to evaluate the association of bone metabolism markers with coronary atherosclerosis and coronary artery disease (CAD) in postmenopausal women. Based on the findings of coronary angiography, 111 women with CAD and 116 women without CAD were recruited. Serum calcium, phosphate, parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), osteocalcin, N-terminal propeptide of type I procollagen (P1NP) and C-terminal cross-linked telopeptide of type I collagen (CTX) were measured. The Gensini score was used to assess the severity of coronary atherosclerosis...
June 22, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28628920/predictive-effects-of-circulating-mir-221-mir-130a-and-mir-155-for-coronary-heart-disease-a-multi-ethnic-study-in-china
#13
Qiao-Wei Jia, Zhao-Hong Chen, Xiao-Qing Ding, Jie-Yin Liu, Peng-Cheng Ge, Feng-Hui An, Li-Hua Li, Lian-Sheng Wang, Wen-Zhu Ma, Zhi-Jian Yang, En-Zhi Jia
BACKGROUND: Differences in microRNA (miRNA) profiles between patients with and without coronary heart disease (CHD)have not been fully determined. The purpose of the study was to evaluate in a multi-ethnic population in China the predictive value of miRNAs previously suggested to have a role in CHD. SUBJECT AND METHOD: 932 participants were included, and plasma samples obtained. A quantitative reverse-transcription PCR(RT-qPCR) assay was conducted to confirm the concentration of plasma miRNAs...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28623858/roles-of-st2-il-33-and-bnp-in-predicting-major-adverse-cardiovascular-events-in-acute-myocardial-infarction-after-percutaneous-coronary-intervention
#14
Yan-Peng Wang, Jian-Hua Wang, Xiao-Long Wang, Jun-Yi Liu, Fang-Yun Jiang, Xiao-Li Huang, Jing-Yu Hang, Wei Qin, Shi-Xin Ma, Jie Zhang, Min-Jie Yuan, Jing-Bo Li, Zhi-Gang Lu, Meng Wei
This study investigated roles of serum ST2, IL-33 and BNP in predicting major adverse cardiovascular events (MACEs) in acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Blood samples were collected from the included AMI patients (n = 180) who underwent PCI. All patients were divided into the MACEs and MACEs-free groups. Enzyme-linked immunosorbent assay was performed to measure serum levels of ST2, IL-33 and BNP. Severity of coronary artery lesion was evaluated by Gensini score...
June 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28623739/high-density-lipoprotein-cholesterol-levels-are-associated-with-coronary-severity-but-not-with-outcomes-in-new-onset-patients-with%C3%A2-stable-coronary-artery-disease
#15
Hui-Hui Liu, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Ying Gao, Ping Qing, Sha Li, Xi Zhao, Yan Zhang, Di Sun, Geng Liu, Qian Dong, Jian-Jun Li
BACKGROUND AND AIMS: The atheroprotective role of high-density lipoprotein cholesterol (HDL-C) levels in coronary artery disease (CAD) remains controversial. This study sought to reappraise the value of HDL-C in predicting the severity and outcomes of new-onset patients with stable CAD in Chinese populations. METHODS: A total of 4205 new-onset patients with stable CAD who received coronary angiography were enrolled to analyze the relation of HDL-C to coronary severity and major adverse cardiovascular events (MACEs)...
June 7, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28616559/gender-differences-in-the-prevalence-of-coronary-artery-tortuosity-and-its-association-with-coronary-artery-disease
#16
Joseph Chiha, Paul Mitchell, Bamini Gopinath, George Burlutsky, Pramesh Kovoor, Aravinda Thiagalingam
BACKGROUND: Little is known about the significance of severe coronary tortuosity (SCT) despite it being a relatively common finding on coronary angiography. We examined whether the presence of tortuosity was influenced by gender or cardiac risk factors. METHODS AND RESULTS: We examined 870 patients (Men = 589, Women = 281) who presented to Westmead Hospital, Sydney, Australia for invasive coronary angiography for the assessment of chest pain due to suspected CAD...
March 2017: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28592149/the-comparison-of-angiographic-scoring-systems-with-the-predictors-of-atherosclerosis
#17
Kamuran Kalkan, Hikmet Hamur, Erkan Yildirim, Emrah Ipek, Emrah Ermis, Mustafa Ozturk, Huseyin Karal, Ali Fuat Korkmaz, Murat Bayantemur, Selami Demirelli
Syntax score (SS) and Gensini score (GS) are used to determine the complexity and severity of coronary artery disease. Although there are some studies indicating the individual relationship of these scoring systems with the carotid intima-media thickness (cIMT) and epicardial fat tissue (EFT), there was no previous study that compared the SS and GS in that respect. We aimed to assess the relationship of SS and GS with predictors of atherosclerosis. We enrolled 522 patients. There were positive correlations between GS and SS tertiles with cIMT and EFT...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28578664/macrophage-migration-inhibitory-factor-promoter-polymorphisms-794-catt5-8-relationship-with-soluble-mif-levels-in-coronary-atherosclerotic-disease-subjects
#18
Lu Qian, Xiao-Yan Wang, Saroj Thapa, Lu-Yuan Tao, Shao-Ze Wu, Gao-Jiang Luo, Lu-Ping Wang, Jiao-Ni Wang, Jie Wang, Ji Li, Ji-Fei Tang, Kang-Ting Ji
BACKGROUND: We analyzed the relationship of -794 CATT5-8 MIF polymorphisms with soluble MIF in Coronary Atherosclerotic Disease (CAD) patients. METHODS: A total of 256 patients selected, on which 186 normal-coronary and 70 Coronary artery disease subjects, were recruited in the study (Retrospectively registered). Genotyping of -794 CATT5-8 polymorphisms were performed by PCR and DNA sequencing. Serum MIF levels were measured using an ELISA kit. Patients were classified by coronary angiogram, and CAD based on Gensini's integral degree (angiographic scoring system)...
June 2, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28571169/significance-of-platelet-volume-indices-in-stemi-patients-a-case-control-study
#19
Sravan K Reddy, Ranjan Shetty, Srujitha Marupuru, Nishanth Yedavalli, Kiran Shetty
INTRODUCTION: Platelets have been well known contributors in the pathogenesis of cardiovascular disorders such as atherosclerosis and its complications such as acute Myocardial Infarction (MI). AIM: To study the changes in platelet volume indices and platelet count in ST-Elevated Myocardial Infarction (STEMI) and assess their usefulness in predicting coronary events. MATERIALS AND METHODS: A case-control observational study was carried out on 173 cases diagnosed with STEMI and 191 controls from January 2015 to December 2015, considering the inclusion and exclusion criteria...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28554251/association-between-circulating-microrna-208a-and-severity-of-coronary-heart-disease
#20
Yao Zhang, Hai-Hong Li, Rui Yang, Bai-Jing Yang, Zhao-Yu Gao
Circulating microRNA (miR)-208a is specifically expressed in the heart muscle, which is involved in the regulation of myosin during cardiac development. Previous studies reported that cardiac-specific miR-208a level is significantly higher in plasma of coronary heart disease (CHD) patients. However, whether it correlates with severity of CHD, has never been elucidated before. The aim of this study was to explore the association between miR-208a and the presence and severity of CHD. Samples were collected from 290 CHD patients and 110 subjects with angiographic exclusion of CHD...
May 30, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
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