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https://www.readbyqxmd.com/read/28629625/what-exactly-regression-of-atherosclerosis-or-foreign-body-reaction-with-hyaline-arteriosclerosis-drives-transient-scaffolding-of-coronary-arteries-a-pooled-analysis-of-observational-absorb-studies-with-a-serial-multimodality-imaging-substudy-of-absorb-cohort
#1
Alexander N Kharlamov, John A Feinstein, John A Cramer, John A Boothroyd
OBJECTIVES: We aimed to estimate the trends of the artery remodeling after transient scaffolding. BACKGROUND: At least 2.62% reduction of the per cent atheroma volume (PAV) or plaque burden (PB) performed in ABSORB B trial at 60months. METHODS: The detailed multiple serial imaging evaluation was performed by intravascular ultrasound (IVUS) in comparison with quantitative coronary angiography (QCA), multislice CT (MSCT) and optical coherence tomography (OCT) thru 24months in the ABSORB cohort B1 trial (n=45) with the pooled analysis in ABSORB A and B trials (n=131)...
June 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28610300/new-species-of-leaf-mining-nepticulidae-lepidoptera-from-the-neotropical-and-ando-patagonian-regions-with-new-data-on-host-plants
#2
Jonas R Stonis, Andrius Remeikis, Arūnas Diškus, Nick Megoran
The paper treats fifteen species of leaf-mining pygmy moths (Insecta, Lepidoptera, Nepticulidae) discovered in the Neotropics (British Virgin Islands, Belize, Costa Rica, Venezuela, and Ecuador), and Ando-Patagonian region (Argentina and Chile). Except for two species, all belong to Stigmella Schrank. Twelve species are new, and are named and described in the current paper: Stigmella apicibrunella Diškus & Stonis, sp. nov.; S. decora Diškus & Stonis, sp. nov.; S. unicaudata Remeikis & Stonis, sp. nov.; S...
May 26, 2017: Zootaxa
https://www.readbyqxmd.com/read/28608135/can-proportional-ventilation-modes-facilitate-exercise-in-critically-ill-patients-a-physiological-cross-over-study-pressure-support-versus-proportional-ventilation-during-lower-limb-exercise-in-ventilated-critically-ill-patients
#3
Evangelia Akoumianaki, Nicolas Dousse, Aissam Lyazidi, Jean-Claude Lefebvre, Severine Graf, Ricardo Luiz Cordioli, Nathalie Rey, Jean-Christophe Marie Richard, Laurent Brochard
BACKGROUND: Early exercise of critically ill patients may have beneficial effects on muscle strength, mass and systemic inflammation. During pressure support ventilation (PSV), a mismatch between demand and assist could increase work of breathing and limit exercise. A better exercise tolerance is possible with a proportional mode of ventilation (Proportional Assist Ventilation, PAV+ and Neurally Adjusted Ventilatory Assist, NAVA). We examined whether, in critically ill patients, PSV and proportional ventilation have different effects on respiratory muscles unloading and work efficiency during exercise...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28592029/-effects-of-noninvasive-proportional-assist-vs-pressure-support-ventilation-on-respiratory-work-in-chronic-obstructive-pulmonary-disease-patients-with-hypercapnia
#4
J H Zhang, Q Luo, H J Zhang, R C Chen
Objective: To investigate the effect of noninvasive proportional assist ventilation (PAV) on respiratory work in chronic obstructive pulmonary disease(COPD) patients, in comparison to noninvasive pressure support ventilation(PSV). Methods: Ten severe COPD patients with hypercapnia during acute exacerbation were examined. The baseline inspiratory pressure of PSV (PS) and the assistance level of PAV(PA) were titrated by patients' tolerance. In addition to the baseline PS and PA, an additional decrease by 25% (PS-=75% PS, PA-=75% PA) or increase by 25% (PS+ =125% PS, PA+ =125% PA) of the assist level were applied to the patients...
June 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28567351/regression-of-coronary-atherosclerosis-with-infusions-of-the-high-density-lipoprotein-mimetic-cer-001-in-patients-with-more-extensive-plaque-burden
#5
Yu Kataoka, Jordan Andrews, MyNgan Duong, Tracy Nguyen, Nisha Schwarz, Jessica Fendler, Rishi Puri, Julie Butters, Constance Keyserling, John F Paolini, Jean-Louis Dasseux, Stephen J Nicholls
BACKGROUND: CER-001 is an engineered pre-beta high-density lipoprotein (HDL) mimetic, which rapidly mobilizes cholesterol. Infusion of CER-001 3 mg/kg exhibited a potentially favorable effect on plaque burden in the CHI-SQUARE (Can HDL Infusions Significantly Quicken Atherosclerosis Regression) study. Since baseline atheroma burden has been shown as a determinant for the efficacy of HDL infusions, the degree of baseline atheroma burden might influence the effect of CER-001. METHODS: CHI-SQUARE compared the effect of 6 weekly infusions of CER-001 (3, 6 and 12 mg/kg) vs...
June 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28556820/placebo-by-proxy-in-neonatal-randomized-controlled-trials-does-it-matter
#6
Tiziana L Burkart, Andrea Kraus, Brigitte Koller, Giancarlo Natalucci, Beatrice Latal, Jean-Claude Fauchère, Hans Ulrich Bucher, Christoph M Rüegger, For The Swiss Epo Neuroprotection Trial Group
Placebo effects emerging from the expectations of relatives, also known as placebo by proxy, have seldom been explored. The aim of this study was to investigate whether in a randomized controlled trial (RCT) there is a clinically relevant difference in long-term outcome between very preterm infants whose parents assume that verum (PAV) had been administered and very preterm infants whose parents assume that placebo (PAP) had been administered. The difference between the PAV and PAP infants with respect to the primary outcome-IQ at 5 years of age-was considered clinically irrelevant if the confidence interval (CI) for the mean difference resided within our pre-specified ±5-point equivalence margins...
May 30, 2017: Children
https://www.readbyqxmd.com/read/28554886/a-rare-case-of-bilateral-lens-dislocations
#7
Fionn Coughlan, Kitty Shakur, Pav Gounder
No abstract text is available yet for this article.
May 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28552880/genotyping-analysis-of-bitter-taste-receptor-genes-tas2r38-and-tas2r46-in-japanese-patients-with-gastrointestinal-cancers
#8
Michiko Yamaki, Hiroki Saito, Kunio Isono, Tomoko Goto, Hitoshi Shirakawa, Noriaki Shoji, Shizuko Satoh-Kuriwada, Takashi Sasano, Ryo Okada, Katsuyoshi Kudoh, Fuyuhiko Motoi, Michiaki Unno, Michio Komai
Type-2 bitter-taste receptors (TAS2Rs) are important for the evaluation of food quality and the nutritional control in animals. Mutations in some TAS2Rs including TAS2R38 are known to increase susceptibility to various diseases. However, the involvement of TAS2Rs in cancers has not been well understood. We conducted a pilot study by genotyping two TAS2R genes, TAS2R38 and TAS2R46, in Japanese cancer patients diagnosed with the following types of cancer: biliary tract cancer, hepatocellular carcinoma, pancreatic cancer, colorectal cancer and gastric cancer...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/28524229/exercise-induced-quadriceps-muscle-fatigue-in-men-and-women-effects-of-arterial-oxygen-content-and-respiratory-muscle-work
#9
Paolo B Dominelli, Yannick Molgat-Seon, Donald E G Griesdale, Carli M Peters, Jean-Sébastien Blouin, Mypinder Sekhon, Giulio S Dominelli, William R Henderson, Glen E Foster, Lee M Romer, Michael S Koehle, A William Sheel
Reducing the work of breathing or eliminating exercise-induced arterial hypoxemia (EIAH) during exercise decreases the severity of quadriceps fatigue in men. Women have a greater work of breathing during exercise, dedicate a greater fraction of whole-body V̇O2 towards their respiratory muscles, and demonstrate EIAH, suggesting women may be especially susceptible to quadriceps fatigue. Healthy subjects (8M, 8F) completed three constant load exercise tests over four days. During the first (control) test, subjects exercised at ∼85% of maximum while arterial blood gases and work of breathing were assessed...
May 19, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28502498/mature-proprotein-convertase-subtilisin-kexin-type-9-coronary-atheroma-burden-and-vessel-remodeling-in-heterozygous-familial-hypercholesterolemia
#10
Yu Kataoka, Mariko Harada-Shiba, Kazuhiro Nakao, Takahiro Nakashima, Shoji Kawakami, Masashi Fujino, Tomoaki Kanaya, Toshiyuki Nagai, Yoshio Tahara, Yasuhide Asaumi, Mika Hori, Masatsune Ogura, Yoichi Goto, Teruo Noguchi, Satoshi Yasuda
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9), an important contributor to low-density lipoprotein metabolism in heterozygous familial hypercholesterolemia (HeFH), exhibits direct proatherogenic effects. PCSK9 circulates as mature and furin-cleaved forms, which differ in its biological activity. However, it remains to be elucidated whether each PCSK9 subtype has different atherogenic properties. OBJECTIVE: To investigate the association of each PCSK9 subtype with coronary atherosclerosis in HeFH...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28499411/paraneoplastic-acral-vascular-syndrome-in-a-patient-with-metastatic-melanoma-under-immune-checkpoint-blockade
#11
Thilo Gambichler, Stefanie Strutzmann, Andrea Tannapfel, Laura Susok
BACKGROUND: Paraneoplastic acral vascular syndrome (PAVS) is a rare phenomenon which is observed in patients with adenocarcinomas and other malignancies. Various potential pathogenic mechanisms such as tumour invasion of sympathetic nerves, hyperviscosity, hypercoagulability, vasoactive tumour-secreted substances, and immunological mechanisms have been suggested. CASE PRESENTATION: We report a 60-year-old Caucasian male attended our hospital with a bulky lymph node mass in the right axilla...
May 12, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28457039/carcinoma-of-unknown-primary-presenting-as-peripheral-symmetric-gangrene
#12
Abhenil Mittal, Sanchit Sharma, Vineet Govinda Gupta, R Ragesh, Neeraj Nischal, Ajay Gogia, Manish Soneja, Chandan J Das, S K Sharma
Cancer of unknown primary accounts for almost 4-5% of all invasive cancers and consists of tumors from various primary sources with considerable heterogeneity in biology and behaviour. Most of these tumors present with symptoms due to distant metastasis. Histology, immunohistochemistry and molecular profiling is the mainstay for diagnosis. In most cases of adenocarinoma associated with paraneoplastic acral vascular syndrome (PAVS), a site in the lung, ovary or uterus is discernible. Here we report a case of metastatic adenoarcinoma of unknown primary presenting as PAVS, a case which to the best of our knowledge has not been reported in published literature...
February 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28455260/tas2r38-and-ca6-genetic-polymorphisms-frequency-of-bitter-food-intake-and-blood-biomarkers-among-elderly-woman
#13
Joanna Mikołajczyk-Stecyna, Anna M Malinowska, Agata Chmurzynska
OBJECTIVE: Taste sensitivity is one of the most important biological determinants of food choice. Three SNPs of the TAS2R38 gene (rs713598, rs1726866, and rs10246939) give rise to two common haplotypes: PAV and AVI. These haplotypes, as well as an SNP within the CA6 gene (rs2274333) that encodes carbonic anhydrase VI (CA6), correlate with bitterness perception. The extent of consumption of bitter food may influence some health outcomes. The aim of this study is thus to investigate the impact of the TAS2R38 and CA6 genetic polymorphisms on the choice of bitter food, BMI, blood lipoprotein, and glucose concentrations as well as systemic inflammation in elderly women...
April 25, 2017: Appetite
https://www.readbyqxmd.com/read/28437358/integrated-multidimensional-maturity-assessments-predicting-the-high-risk-occurrence-of-peak-angle-velocity-during-puberty-in-progressive-female-idiopathic-scoliosis
#14
Benlong Shi, Saihu Mao, Leilei Xu, Xu Sun, Zezhang Zhu, Bangping Qian, Zhen Liu, Jack Chun Yiu Cheng, Yong Qiu
STUDY DESIGN: A consecutive and prospective longitudinal study. OBJECTIVE: To propose an integrated multidimensional maturity assessment that was designated as forming a reliable system precisely predicting the high-risk occurrence of peak angle velocity (PAV) in a group of progressive braced female idiopathic scoliosis (IS). SUMMARY OF BACKGROUND DATA: Scoliosis deterioration is believed to keep pace with the evolution of skeletal maturity during puberty...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28419861/agroecological-and-environmental-factors-influence-barley-yellow-dwarf-viruses-in-grasslands-in-the-us-pacific-northwest
#15
Laura L Ingwell, Christelle Lacroix, Paul R Rhoades, Alexander V Karasev, Nilsa A Bosque-Pérez
Plant pathogens can play a role in the competitive interactions between plant species and have been understudied in native prairies, which are declining globally, and in Conservation Reserve Program (CRP) lands in the United States. Barley/Cereal yellow dwarf virus (B/CYDV) are among the most economically important disease-causing agents of small grain cereal crops, such as wheat, and are known to infect over 150 Poaceae species, including many of the grass species present in prairies and CRP lands. Field surveys of Poaceae species were conducted in endangered Palouse Prairie and CRP habitats of southeastern Washington and adjacent northern Idaho, USA from 2010-2012 to examine for the presence of B/CYDV among plant hosts and aphid vectors...
April 15, 2017: Virus Research
https://www.readbyqxmd.com/read/28373278/flavones-modulate-respiratory-epithelial-innate-immunity-anti-inflammatory-effects-and-activation-of-the-t2r14-receptor
#16
Benjamin M Hariri, Derek B McMahon, Bei Chen, Jenna R Freund, Corrine J Mansfield, Laurel J Doghramji, Nithin D Adappa, James N Palmer, David W Kennedy, Danielle R Reed, Peihua Jiang, Robert J Lee
Chronic rhinosinusitis has a significant impact on patient quality of life, creates billions of dollars of annual healthcare costs, and accounts for ∼20% of adult antibiotic prescriptions in the United States. Because of the rise of resistant microorganisms, there is a critical need to better understand how to stimulate and/or enhance innate immune responses as a therapeutic modality to treat respiratory infections. We recently identified bitter taste receptors (taste family type 2 receptors, or T2Rs) as important regulators of sinonasal immune responses and potentially important therapeutic targets...
May 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28369557/improving-health-literacy-in-community-populations-a-review-of-progress
#17
Don Nutbeam, Bronwyn McGill, Pav Premkumar
Governments around the world have adopted national policies and programs to improve health literacy. This paper examines progress in the development of evidence to support these policies from interventions to improve health literacy among community populations. Our review found only a limited number of studies (n=7) that met the criteria for inclusion, with many more influenced by the concept of health literacy but not using it in the design and evaluation. Those included were diverse in setting, population and intended outcomes...
March 28, 2017: Health Promotion International
https://www.readbyqxmd.com/read/28350245/influence-of-background-noise-produced-in-university-facilities-on-the-brain-waves-associated-with-attention-of-students-and-employees
#18
E Trista N-Hernández, I Pav On-García, I Campos-Cantón, L J Ontaño N-García, E S Kolosovas-Machuca
As a consequence of noise exposure, lack of attention badly affects directly the academic and work performance. The study of the brain and the waves that it produces is the most objective way to evaluate this process. Attentional improvement is associated with increases of the amplitude in both beta and theta bands. The objective of this work is to study the influence of background noise produced inside university facilities on changes in the cerebral waves related to attention processes (beta 13-30 Hz and theta 4-7 Hz)...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/28298108/analytic-energy-gradient-of-projected-hartree-fock-within-projection-after-variation
#19
Motoyuki Uejima, Seiichiro Ten-No
We develop a geometrical optimization technique for the projection-after-variation (PAV) scheme of the recently refined projected Hartree-Fock (PHF) as a fast alternative to the variation-after-projection (VAP) approach for optimizing the structures of molecules/clusters in symmetry-adapted electronic states at the mean-field computational cost. PHF handles the nondynamic correlation effects by restoring the symmetry of a broken-symmetry single reference wavefunction and moreover enables a black-box treatment of orbital selections...
March 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28273795/pavs-a-new-privacy-preserving-data-aggregation-scheme-for-vehicle-sensing-systems
#20
Chang Xu, Rongxing Lu, Huaxiong Wang, Liehuang Zhu, Cheng Huang
Air pollution has become one of the most pressing environmental issues in recent years. According to a World Health Organization (WHO) report, air pollution has led to the deaths of millions of people worldwide. Accordingly, expensive and complex air-monitoring instruments have been exploited to measure air pollution. Comparatively, a vehicle sensing system (VSS), as it can be effectively used for many purposes and can bring huge financial benefits in reducing high maintenance and repair costs, has received considerable attention...
March 3, 2017: Sensors
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