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https://www.readbyqxmd.com/read/28345642/dynamic-changes-in-amygdala-psychophysiological-connectivity-reveal-distinct-neural-networks-for-facial-expressions-of-basic-emotions
#1
Matteo Diano, Marco Tamietto, Alessia Celeghin, Lawrence Weiskrantz, Mona-Karina Tatu, Arianna Bagnis, Sergio Duca, Giuliano Geminiani, Franco Cauda, Tommaso Costa
The quest to characterize the neural signature distinctive of different basic emotions has recently come under renewed scrutiny. Here we investigated whether facial expressions of different basic emotions modulate the functional connectivity of the amygdala with the rest of the brain. To this end, we presented seventeen healthy participants (8 females) with facial expressions of anger, disgust, fear, happiness, sadness and emotional neutrality and analyzed amygdala's psychophysiological interaction (PPI). In fact, PPI can reveal how inter-regional amygdala communications change dynamically depending on perception of various emotional expressions to recruit different brain networks, compared to the functional interactions it entertains during perception of neutral expressions...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28344074/aberrant-distributions-of-nuclear-pore-complex-proteins-in-als-mice-and-als-patients
#2
Jingwei Shang, Toru Yamashita, Yumiko Nakano, Ryuta Morihara, Xianghong Li, Tian Feng, Xia Liu, Yong Huang, Yusuke Fukui, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe
Nuclear pore complexes (NPCs) play important roles in traffic of molecules between the nucleus and cytoplasm, aberrant distributions of components of NPCs were demonstrated in C9orf72 amyotrophic lateral sclerosis (C9-ALS) patients, but it is elusive whether such abnormities are also the case with other cause of ALS disease. In the present study, we investigated the spatiotemporal distributions of RanGAP1 and 4 representative nucleoporins (GP210, NUP205, NUP107 and NUP50) of NPCs in human Cu/Zn superoxide dismutase-1 mutation transgenic (SOD1-Tg) mice and sporadic ALS patients...
March 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/28342444/acid-ceramidase-deficiency-in-mice-results-in-a-broad-range-of-central-nervous-system-abnormalities
#3
Jakub Sikora, Shaalee Dworski, E Ellen Jones, Mustafa A Kamani, Matthew C Micsenyi, Tomo Sawada, Pauline Le Faouder, Justine Bertrand-Michel, Aude Dupuy, Christopher K Dunn, Ingrid Cong Yang Xuan, Josefina Casas, Gemma Fabrias, David R Hampson, Thierry Levade, Richard R Drake, Jeffrey A Medin, Steven U Walkley
Farber disease is a rare autosomal recessive disorder caused by acid ceramidase deficiency that usually presents as early-onset progressive visceral and neurologic disease. To understand the neurologic abnormality, we investigated behavioral, biochemical, and cellular abnormalities in the central nervous system of Asah1(P361R/P361R) mice, which serve as a model of Farber disease. Behaviorally, the mutant mice had reduced voluntary locomotion and exploration, increased thigmotaxis, abnormal spectra of basic behavioral activities, impaired muscle grip strength, and defects in motor coordination...
April 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28342367/optimization-of-surface-electrodes-location-for-h-reflex-recordings-in-soleus-muscle
#4
Alberto Botter, Taian M Vieira
The Hoffmann reflex (H reflex) is extensively used to investigate the spinal motor neuron excitability in healthy and pathological subjects. Obtaining a representative and robust amplitude estimation of the H reflex is of marked relevance in clinical as well as in research applications. As for the motor responses, this issue is strictly related to the electrode positioning, especially for large, pinnate muscles such as the triceps surae. In this study we investigated the effect of electrode position on soleus H-reflex amplitude...
March 16, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28340317/opportunities-for-crash-and-injury-reduction-a-multi-harm-approach-for-crash-data-analysis
#5
Ann Mallory, Allison Kender, Kevin Moorhouse
OBJECTIVE: A multi-harm approach for analyzing crash and injury data was developed for the ultimate purpose of getting a richer picture of motor vehicle crash outcomes identifying research opportunities in crash safety. METHODS: Methods were illustrated using a retrospective analysis of 69,597 occupant cases from NASS CDS (National Automotive Sampling System Crashworthiness Data System) from 2005 to 2015. Occupant cases were analyzed by frequency and severity of outcome: fatality, injury by AIS (Abbreviated Injury Scale), number of cases, attributable fatality, disability, and injury costs...
March 24, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28340277/immunomodulatory-and-neuroprotective-effect-of-cryopreserved-allogeneic-mesenchymal-stem-cells-on-spinal-cord-injury-in-rats
#6
I R Rosado, P H Carvalho, E G L Alves, T M Tagushi, J L Carvalho, J F Silva, M S L Lavor, K M Oliveira, R Serakides, A M Goes, E G Melo
This study aimed to evaluate the immunomodulatory and neuroprotective effects of allogeneic and cryopreserved mesenchymal stem cells (MSCs) on spinal cord injury. A total of 120 rats were distributed into the following groups: negative control (NC) - without injury, positive control (PC) - with injury without treatment, and group treated with MSC (GMSC) - with injury and treated. Motor function was evaluated by the BBB test at 24, 48, and 72 h and at 8 and 21 postoperative days. Spinal cords were evaluated by histopathology and immunohistochemistry to determine the expression of CD68, NeuN, and GFAP...
March 22, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28336544/high-resolution-anatomical-correlation-of-cyclic-motor-patterns-in-the-human-colon-evidence-of-a-rectosigmoid-brake
#7
Anthony Y Lin, Peng Du, Philip G Dinning, John W Arkwright, Jozef P Kamp, Leo K Cheng, Ian P Bissett, Gregory O'Grady
Colonic cyclic motor patterns (CMPs) have been hypothesized to act as a brake to limit rectal filling. However, the spatiotemporal profile of CMPs, including anatomical origins and distributions, remains unclear. This study characterized colonic CMPs using high-resolution (HR) manometry (72 sensors, 1 cm resolution) and their relationship with proximal antegrade propagating events. Nine healthy volunteers were recruited. Recordings were performed over 4 h, with a 700 kcal meal given after 2 h. Propagating events were visually identified and analyzed by pattern, origin, amplitude, extent of propagation, velocity, and duration...
March 23, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28335024/impaired-dual-tasking-in-parkinson-s-disease-is-associated-with-reduced-focusing-of-cortico-striatal-activity
#8
Freek Nieuwhof, Bastiaan R Bloem, Miriam F Reelick, Esther Aarts, Inbal Maidan, Anat Mirelman, Jeffrey M Hausdorff, Ivan Toni, Rick C Helmich
Impaired dual tasking, namely the inability to concurrently perform a cognitive and a motor task (e.g. 'stops walking while talking'), is a largely unexplained and frequent symptom of Parkinson's disease. Here we consider two circuit-level accounts of how striatal dopamine depletion might lead to impaired dual tasking in patients with Parkinson's disease. First, the loss of segregation between striatal territories induced by dopamine depletion may lead to dysfunctional overlaps between the motor and cognitive processes usually implemented in parallel cortico-striatal circuits...
March 17, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28334851/the-modulatory-effect-of-adaptive-deep-brain-stimulation-on-beta-bursts-in-parkinson-s-disease
#9
Gerd Tinkhauser, Alek Pogosyan, Simon Little, Martijn Beudel, Damian M Herz, Huiling Tan, Peter Brown
Adaptive deep brain stimulation uses feedback about the state of neural circuits to control stimulation rather than delivering fixed stimulation all the time, as currently performed. In patients with Parkinson's disease, elevations in beta activity (13-35 Hz) in the subthalamic nucleus have been demonstrated to correlate with clinical impairment and have provided the basis for feedback control in trials of adaptive deep brain stimulation. These pilot studies have suggested that adaptive deep brain stimulation may potentially be more effective, efficient and selective than conventional deep brain stimulation, implying mechanistic differences between the two approaches...
February 13, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28333379/motor-neurons
#10
Jorn Hounsgaard
Motor neurons translate synaptic input from widely distributed premotor networks into patterns of action potentials that orchestrate motor unit force and motor behavior. Intercalated between the CNS and muscles, motor neurons add to and adjust the final motor command. The identity and functional properties of this facility in the path from synaptic sites to the motor axon is reviewed with emphasis on voltage sensitive ion channels and regulatory metabotropic transmitter pathways. The catalog of the intrinsic response properties, their underlying mechanisms, and regulation obtained from motoneurons in in vitro preparations is far from complete...
March 16, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28329855/better-cognition-in-new-birth-cohorts-of-70-year-olds-but-greater-decline-thereafter
#11
Valgeir Thorvaldsson, Peter Karlsson, Johan Skoog, Ingmar Skoog, Boo Johansson
Objectives: To evaluate birth cohort differences in level of cognition and rate of change in old age. Methods: Data were drawn from three population-based Swedish samples including age-homogenous cohorts born 1901/02, 1906/07, and 1930, and measured on the same cognitive tests at ages 70, 75, and 79 as part of the Gerontological and Geriatric Populations Studies in Gothenburg (H70). We fitted growth curve models to the data using a Bayesian framework and derived estimates and inferences from the marginal posterior distributions...
December 9, 2016: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28327949/resection-of-navigated-transcranial-magnetic-stimulation-positive-prerolandic-motor-areas-causes-permanent-impairment-of-motor-function
#12
Tobias Moser, Lucia Bulubas, Jamil Sabih, Neal Conway, Noémie Wildschutz, Nico Sollmann, Bernhard Meyer, Florian Ringel, Sandro M Krieg
BACKGROUND: Navigated transcranial magnetic stimulation (nTMS) helps to determine the distribution of motor eloquent areas prior to brain surgery. Yet, the eloquence of primary motor areas frontal to the precentral gyrus identified via nTMS is unclear. OBJECTIVE: To investigate the resection of nTMS-positive prerolandic motor areas and its correlation with postsurgical impairment of motor function. METHODS: Forty-three patients with rolandic or prerolandic gliomas (WHO grade I-IV) underwent nTMS prior to surgery...
February 24, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28326439/a-distinct-functional-distribution-of-%C3%AE-and-%C3%AE-motoneurons-in-the-rat-trigeminal-motor-nucleus
#13
Yukako Morita-Isogai, Hajime Sato, Mitsuru Saito, Eriko Kuramoto, Dong Xu Yin, Takeshi Kaneko, Takashi Yamashiro, Kenji Takada, Seog Bae Oh, Hiroki Toyoda, Youngnam Kang
Gamma-motoneurons (γMNs) play a crucial role in regulating isometric muscle contraction. The slow jaw-closing during mastication is one of the most functional isometric contractions, which is developed by the rank-order recruitment of alpha-motoneurons (αMNs) in a manner that reflects the size distribution of αMNs. In a mouse spinal motor nucleus, there are two populations of small and large MNs; the former was identified as a population of γMNs based on the positive expression of the transcription factor estrogen-related receptor 3 (Err3) and negative expression of the neuronal DNA-binding protein NeuN, and the latter as that of αMNs based on the opposite pattern of immunoreactivity...
March 22, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28323091/age-related-differences-in-functional-synchronization-of-eeg-activity-as-evaluated-by-means-of-tms-eeg-coregistrations
#14
Florinda Ferreri, Fabrizio Vecchio, Andrea Guerra, Francesca Miraglia, David Ponzo, Luca Vollero, Giulio Iannello, Sara Maatta, Esa Mervaala, Paolo Maria Rossini, Vincenzo Di Lazzaro
It was recently demonstrated that the characteristics of EEG rhythms preceding a transcranial magnetic stimulation (TMS) of the motor cortex (M1) influence the motor-evoked potential (MEP) amplitude with a peculiar pattern, thus reflecting the M1 functional state. As physiological aging is related to a decrease in motor performance and changes in excitability and connectivity strength within cerebral sensorimotor circuits, we aimed to explore whether aging affects EEG-MEP interactions. Using MRI-navigated TMS and multichannel EEG, we compared the EEG-MEP interactions observed in healthy aged subjects with those observed in young volunteers...
March 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28322752/neuroprotector-effect-of-stem-cells-from-human-exfoliated-deciduous-teeth-transplanted-after-traumatic-spinal-cord-injury-involves-inhibition-of-early-neuronal-apoptosis
#15
Fabrício do Couto Nicola, Marília Rossato Marques, Felipe Odorcyk, Danusa Mar Arcego, Letícia Petenuzzo, Dirceu Aristimunha, Adriana Vizuete, Eduardo Farias Sanches, Daniela Pavulack Pereira, Natasha Maurmann, Carla Dalmaz, Patricia Pranke, Carlos A Netto
Stem cells from human exfoliated deciduous teeth (SHED) transplants have been investigated as a possible treatment strategy for spinal cord injuries (SCI) due to their potential for promoting functional recovery. The aim of present study was to investigate the effects of SHED on neuronal death after an experimental model of SCI. METHODS: Wistar rats were spinalized using NYU impactor®. Animals were randomly distributed into 4 groups: Control (Naive) or Surgical control, Sham (laminectomy with no SCI); SCI (laminectomy followed by SCI, treated with vehicle); SHED (SCI treated with intraspinal transplantation of 3×10(5) SHED, 1 h after SCI)...
March 16, 2017: Brain Research
https://www.readbyqxmd.com/read/28322742/potassium-channel-abnormalities-are-consistent-with-early-axon-degeneration-of-motor-axons-in-the-g127x-sod1-mouse-model-of-amyotrophic-lateral-sclerosis
#16
Rikke Maglemose, Anne Hedegaard, Janna Lehnhoff, Kristina Petrova Dimintiyanova, Mihai Moldovan, Lillian Grøndahl, Claire Francesca Meehan
Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease, which selectively affects upper and lower motoneurones. The underlying pathophysiology of the disease is complex but electrophysiological studies of peripheral nerves in ALS patients as well as human autopsy studies indicate that a potassium channel dysfunction/loss is present early in the symptomatic phase. It remains unclear to what extent potassium channel abnormalities reflect a specific pathogenic mechanism in ALS. The aim of this study was therefore to investigate the temporal changes in the expression and/or function of potassium channels in motoneurones in the adult G127X SOD1 mouse model of ALS, a model which has a very long presymptomatic phase...
March 16, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28320672/spatial-analysis-of-multichannel-surface-emg-in-hemiplegic-stroke
#17
Ghulam Rasool, Babak Afsharipour, Nina Suresh, William Z Rymer
We investigated spatial activation patterns of upper extremity muscles during isometric force generation in both intact persons and in hemispheric stroke survivors. We used a 128-channel surface electromyogram (EMG) grid to record the electrical activity of biceps brachii muscles during these contractions. EMG data were processed to develop 2-dimensional root mean square (RMS) maps of muscle activity. Our objective was to determine whether motor impairments following stroke were associated with changes in the muscle activity maps and in the spatial distribution of muscular activation...
March 15, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28320669/regularized-speaker-adaptation-of-kl-hmm-for-dysarthric-speech-recognition
#18
Myungjong Kim, Younggwan Kim, Joohong Yoo, Jun Wang, Hoirin Kim
This paper addresses the problem of recognizing the speech uttered by patients with dysarthria, which is a motor speech disorder impeding the physical production of speech. Patients with dysarthria have articulatory limitation, and therefore, they often have trouble in pronouncing certain sounds, resulting in undesirable phonetic variation. Modern automatic speech recognition systems designed for regular speakers are ineffective for dysarthric sufferers due to the phonetic variation. To capture the phonetic variation, Kullback-Leibler divergence based hidden Markov model (KL-HMM) is adopted, where the emission probability of state is parametrized by a categorical distribution using phoneme posterior probabilities obtained from a deep neural network-based acoustic model...
March 13, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28320133/rest-tremor-in-parkinson-s-disease-body-distribution-and-time-of-appearance
#19
Angelo Fabio Gigante, Roberta Pellicciari, Giovanni Iliceto, Daniele Liuzzi, Paola Vincenza Mancino, Giacomo Emanuele Custodero, Marco Guido, Paolo Livrea, Giovanni Defazio
OBJECTIVE: To assess body distribution and timing of appearance of rest tremor in Parkinson's disease. METHODS: Information was obtained by a computerized database containing historical information collected at the first visit and data collected during the subsequent follow-up visits. Information on rest tremor developed during the follow-up could be therefore obtained by our own observation in a proportion of patients. RESULTS: Among 289 patients, rest tremor was reported at disease onset in 65...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28317555/the-cervical-spine-of-australopithecus-sediba
#20
Marc R Meyer, Scott A Williams, Peter Schmid, Steven E Churchill, Lee R Berger
Cervical vertebrae are rare in the early hominin fossil record, presenting a challenge for understanding the evolution of the neck and head carriage in hominin evolution. Here, we examine the cervical vertebrae of Australopithecus sediba, which unlike other South African taxa is known from associated cervical vertebrae. The A. sediba cervical vertebrae exhibit human-like values for wedging, pedicle cross-sectional areas, and articular facet heights, indicating reduced ventral loading relative to African apes...
March 2017: Journal of Human Evolution
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