keyword
MENU ▼
Read by QxMD icon Read
search

motor AND distributed

keyword
https://www.readbyqxmd.com/read/29465787/nonmotor-symptoms-evolution-during-24-months-of-bilateral-subthalamic-stimulation-in-parkinson-s-disease
#1
Haidar S Dafsari, Monty Silverdale, Marian Strack, Alexandra Rizos, Keyoumars Ashkan, Picabo Mahlstedt, Lena Sachse, Julia Steffen, Till A Dembek, Veerle Visser-Vandewalle, Julian Evans, Angelo Antonini, Pablo Martinez-Martin, K Ray-Chaudhuri, Lars Timmermann
BACKGROUND: The objective of this study was to investigate 24-month of effects of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) on nonmotor symptoms in Parkinson's disease (PD). METHODS: In this prospective, observational, multicenter, international study including 67 PD patients undergoing bilateral STN-DBS, we examined the Non-motor Symptom Scale, Non-Motor Symptoms Questionnaire, Parkinson's Disease Questionnaire-8, Scales for Outcomes in Parkinson's Disease-motor examination, -activities of daily living, and -complications, and levodopa-equivalent daily dose preoperatively and at 5 and 24-month of follow-up...
February 21, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29465486/hypercholesterolemia-is-associated-with-the-subjective-evaluation-of-postoperative-outcomes-in-patients-with-idiopathic-carpal-tunnel-syndrome-who-undergo-surgery-a-multivariate-analysis
#2
Koichi Yano, Akira Kawabata, Mikinori Ikeda, Keisuke Suzuki, Yasunori Kaneshiro, Takeshi Egi
BACKGROUND: Carpal tunnel syndrome (CTS) is a compression neuropathy of the median nerve at the wrist; its symptoms include neuropathic pain and sensory and motor disturbance distributed by the median nerve. CTS and hypercholesterolemia have similar backgrounds, but the effect of these similarities on postoperative outcomes has not been reported. Using multivariate analysis, we analyzed the relationship between patients' subjective opinion of their postoperative symptoms compared to preoperative symptoms and prognostic factors, focusing on hypercholesterolemia in patients with idiopathic CTS treated surgically...
February 9, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29465326/corrective-response-times-in-a-coordinated-eye-head-arm-countermanding-task
#3
Gordon Tao, Aarlenne Zein Khan, Gunnar Blohm
Inhibition of motor responses has been described as a race between two competing decision processes of motor initiation and inhibition, which manifest as the reaction time (RT) and the stop signal reaction time (SSRT); in the case where motor initiation wins out over inhibition, an erroneous movement occurs that usually needs to be corrected leading to corrective response times (CRT). Here we used a combined eye-head-arm movement countermanding task to investigate the mechanisms governing multiple effector coordination and the timing of corrective responses...
February 21, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29465306/sex-dimorphism-in-the-distribution-of-adipose-tissue-and-its-influence-on-proinflammatory-adipokines-and-cardiometabolic-profiles-in-motor-complete-spinal-cord-injury
#4
Gary J Farkas, Ashraf S Gorgey, David R Dolbow, Arthur S Berg, David R Gater
OBJECTIVE: We aimed to examine the influence of sex on the distribution of adipose tissue, as well as proinflammatory adipokine and cardiometabolic profiles, in chronic motor complete spinal cord injury (SCI). DESIGN: Cross-sectional and correlational study. SETTING: Academic rehabilitation hospital. PARTICIPANTS: Forty-seven individuals with chronic motor complete SCI classified according to sex (males: age 44.0 ± 10...
February 21, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29464374/heterogeneous-pattern-of-autonomic-dysfunction-in-parkinson-s-disease
#5
Laurène Leclair-Visonneau, Laurent Magy, Christelle Volteau, Thomas Clairembault, Séverine Le Dily, Cécile Préterre, Arnaud Peyre, Philippe Damier, Michel Neunlist, Yann Péréon, Pascal Derkinderen
Dysautonomic symptoms are frequent non-motor complaints in patients with Parkinson's disease. Numerous neuropathological studies have shown that Lewy bodies and neurites, the pathological hallmarks of Parkinson's disease, are widely distributed throughout the peripheral autonomic nervous systems and across end organs. However, few investigations integrally explored the symptoms and physiology of dysautonomia in Parkinson's disease. We, therefore, performed a comprehensive evaluation of the autonomic function in a prospective group of 45 patients with idiopathic Parkinson's disease...
February 20, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29463867/optogenetic-tractography-for-anatomo-functional-characterization-of-cortico-subcortical-neural-circuits-in-non-human-primates
#6
S Senova, C Poupon, J Dauguet, H J Stewart, G P Dugué, C Jan, K Hosomi, G S Ralph, L Barnes, X Drouot, C Pouzat, J F Mangin, F Pain, I Doignon, R Aron-Badin, E Brouillet, E S Boyden, K A Mitrophanous, P Hantraye, S Palfi
Dissecting neural circuitry in non-human primates (NHP) is crucial to identify potential neuromodulation anatomical targets for the treatment of pharmacoresistant neuropsychiatric diseases by electrical neuromodulation. How targets of deep brain stimulation (DBS) and cortical targets of transcranial magnetic stimulation (TMS) compare and might complement one another is an important question. Combining optogenetics and tractography may enable anatomo-functional characterization of large brain cortico-subcortical neural pathways...
February 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29462071/the-relationship-between-improvements-in-myelopathy-and-sagittal-realignment-in-cervical-deformity-surgery-outcomes
#7
Peter Gust Passias, Samantha R Horn, Cole A Bortz, Subaraman Ramachandran, Douglas C Burton, Themistocles Protopsaltis, Renaud Lafage, Virginie Lafage, Bassel G Diebo, Gregory W Poorman, Frank A Segreto, Justin S Smith, Christopher Ames, Christopher I Shaffrey, Han Jo Kim, Brian Neuman, Alan H Daniels, Alexandra Soroceanu, Eric Klineberg
STUDY DESIGN: Retrospective review. OBJECTIVE: Determine if alignment or myelopathy improvement drives patient outcomes following cervical deformity(CD) corrective surgery. SUMMARY OF BACKGROUND DATA: CD correction involves radiographic malalignment correction and procedures to improve motor function and pain. It is unknown whether alignment or myelopathy improvement drives patient outcomes. METHODS: Inclusion: CD patients with baseline/1-year radiographic and outcome scores...
February 16, 2018: Spine
https://www.readbyqxmd.com/read/29459371/dendritic-a-current-in-rhythmically-active-preb%C3%A3-tzinger-complex-neurons-in-organotypic-cultures-from-newborn-mice
#8
Wiktor S Phillips, Christopher A Del Negro, Jens C Rekling
The brainstem preBötzinger complex (preBötC) generates the inspiratory rhythm for breathing. The onset of neural activity that precipitates the inspiratory phase of the respiratory cycle may depend on the activity of type-1 preBötC neurons, which exhibit a transient outward K+ current, IA Inspiratory rhythm generation can be studied ex vivo since the preBötC remains rhythmically active in vitro , both in acute brainstem slices and organotypic cultures. Advantageous optical conditions in organotypic slice cultures from newborn mice of either sex allowed us to investigate how IA impacts Ca2+ transients occurring in the dendrites of rhythmically active type-1 preBötC neurons...
February 19, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29456706/comparison-of-single-and-triple-injection-methods-for-ultrasound-guided-interscalene-brachial-plexus-blockade
#9
Cun-Jin Wang, Ya-Li Ge, Ju Gao, Feng-Yun Long, Zhi-Hua Mi, Tian-Feng Huang, Xiang-Zhi Fang, Xiao-Ping Chen, Yu-Si Hua, Yang Zhang
Ultrasound-guided interscalene brachial plexus blockade (IBPB) has a relatively high success rate in shoulder surgery; however, whether multiple injections are superior to a single injection (SI) is currently unknown. In the present study, ultrasound-guided SI and triple-injection (TI) IBPBs were compared in a prospective randomized trial. A total of 111 patients undergoing arthroscopic shoulder surgery and presenting with an American Society of Anesthesiologists physical status grading of I-II were randomly allocated to receive IBPB with 15 ml of 1% ropivacaine as a SI or TI...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29451447/peripheral-nerve-grafts-implanted-into-the-substantia-nigra-in-patients-with-parkinson-s-disease-during-deep-brain-stimulation-surgery-1-year-follow-up-study-of-safety-feasibility-and-clinical-outcome
#10
Craig G van Horne, Jorge E Quintero, John T Slevin, Amelia Anderson-Mooney, Julie A Gurwell, Andrew S Welleford, John R Lamm, Renee P Wagner, Greg A Gerhardt
OBJECTIVE Currently, there is no treatment that slows or halts the progression of Parkinson's disease. Delivery of various neurotrophic factors to restore dopaminergic function has become a focus of study in an effort to fill this unmet need for patients with Parkinson's disease. Schwann cells provide a readily available source of such factors. This study presents a 12-month evaluation of safety and feasibility, as well as the clinical response, of implanting autologous peripheral nerve grafts into the substantia nigra of patients with Parkinson's disease at the time of deep brain stimulation (DBS) surgery...
February 16, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29450943/cortical-projections-to-the-superior-colliculus-in-gray-squirrels-sciurus-carolinensis
#11
Mary K L Baldwin, Nicole A Young, Denis Matrov, Jon H Kaas
The superior colliculus is an important midbrain structure involved with integrating information from varying sensory modalities and sending motor signals to produce orienting movements toward environmental stimuli. Because of this role, the superior colliculus receives a multitude of sensory inputs from a wide variety of subcortical and cortical structures. Proportionately, the superior colliculus of gray squirrels is among the largest in size of all studied mammals, suggesting the importance of this structure in the behavioral characteristics of gray squirrels...
February 16, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29449001/balance-assessment-during-squatting-exercise-a-comparison-between-laboratory-grade-force-plate-and-a-commercial-low-cost-device
#12
Alessandro Mengarelli, Federica Verdini, Stefano Cardarelli, Francesco Di Nardo, Laura Burattini, Sandro Fioretti
Testing balance through squatting exercise is a central part of many rehabilitation programs and sports and plays also an important role in clinical evaluation of residual motor ability. The assessment of center of pressure (CoP) displacement and its parametrization is commonly used to describe and analyze squat movement and the laboratory-grade force plates (FP) are the gold standard for measuring balance performances from a dynamic view-point. However, the Nintendo Wii Balance Board (NWBB) has been recently proposed as an inexpensive and easily available device for measuring ground reaction force and CoP displacement in standing balance tasks...
February 5, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29448073/neurite-imaging-reveals-microstructural-variations-in-human-cerebral-cortical-gray-matter
#13
Hikaru Fukutomi, Matthew F Glasser, Hui Zhang, Joonas A Autio, Timothy S Coalson, Tomohisa Okada, Kaori Togashi, David C Van Essen, Takuya Hayashi
We present distinct patterns of neurite distribution in the human cerebral cortex using diffusion magnetic resonance imaging (MRI). We analyzed both high-resolution structural (T1w and T2w images) and diffusion MRI data in 505 subjects from the Human Connectome Project. Neurite distributions were evaluated using the neurite orientation dispersion and density imaging (NODDI) model, optimized for gray matter, and mapped onto the cortical surface using a method weighted towards the cortical mid-thickness to reduce partial volume effects...
February 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29445332/motor-unit-action-potential-clustering-theoretical-consideration-for-muscle-activation-during-a-motor-task
#14
Michael J Asmussen, Vinzenz von Tscharner, Benno M Nigg
During dynamic or sustained isometric contractions, bursts of muscle activity appear in the electromyography (EMG) signal. Theoretically, these bursts of activity likely occur because motor units are constrained to fire temporally close to one another and thus the impulses are "clustered" with short delays to elicit bursts of muscle activity. The purpose of this study was to investigate whether a sequence comprised of "clustered" motor unit action potentials (MUAP) can explain spectral and amplitude changes of the EMG during a simulated motor task...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29445114/kinesin-1-regulates-cilia-length-through-an-interaction-with-the-bardet-biedl-syndrome-related-protein-ccdc28b
#15
Rossina Novas, Magdalena Cardenas-Rodriguez, Paola Lepanto, Matías Fabregat, Magela Rodao, María Inés Fariello, Mauricio Ramos, Camila Davison, Gabriela Casanova, Lucía Alfaya, Federico Lecumberry, Gualberto González-Sapienza, Florencia Irigoín, Jose L Badano
Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinal degeneration, obesity, polydactyly, renal disease and mental retardation. CCDC28B is a BBS-associated protein that we have previously shown plays a role in cilia length regulation whereby its depletion results in shortened cilia both in cells and Danio rerio (zebrafish). At least part of that role is achieved by its interaction with the mTORC2 component SIN1, but the mechanistic details of this interaction and/or additional functions that CCDC28B might play in the context of cilia remain poorly understood...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444426/inferior-olive-hcn1-channels-coordinate-synaptic-integration-and-complex-spike-timing
#16
Derek L F Garden, Marlies Oostland, Marta Jelitai, Arianna Rinaldi, Ian Duguid, Matthew F Nolan
Cerebellar climbing-fiber-mediated complex spikes originate from neurons in the inferior olive (IO), are critical for motor coordination, and are central to theories of cerebellar learning. Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels expressed by IO neurons have been considered as pacemaker currents important for oscillatory and resonant dynamics. Here, we demonstrate that in vitro, network actions of HCN1 channels enable bidirectional glutamatergic synaptic responses, while local actions of HCN1 channels determine the timing and waveform of synaptically driven action potentials...
February 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/29443501/magnetically-actuated-peanut-colloid-motors-for-cell-manipulation-and-patterning
#17
Zhihua Lin, Xinjian Fan, Mengmeng Sun, Changyong Gao, Qiang He, Hui Xie
We report a magnetically-actuated, peanut-shaped hematite colloid motor that can not only move in a rolling or wobbling mode in fluids but also perform single-cell manipulation and patterning in a non-contact manner. The peanut motor in the rolling mode can reach a maximal velocity of 10.6 μm s-1 under a rotating magnetic field of 130 Hz and 6.3 mT and can achieve a more precisely controllable motion in predefined tracks. By comparison, the peanut motor in the wobbling mode can reach a maximal velocity of 14...
February 14, 2018: ACS Nano
https://www.readbyqxmd.com/read/29441900/role-of-the-endocannabinoid-system-in-the-formation-and-development-of-depression
#18
Dan Zhou, Yue Li, Tian Tian, Wei Quan, Lei Wang, Qing Shao, Lian-Qiang Fu, Xiao-Hong Zhang, Xiao-Ye Wang, Hui Zhang, Yan-Min Ma
Two types of cannabinoid (CB) receptors have been described in the human body: CB1 and CB2 receptors. CB1 receptor distribution may be related to the cannabinoid functions of memory and cognition regulation as well as motor control. In addition, the endocannabinoid system (ECS) related to CB1 receptors may be involved in human emotion regulation, especially depression occurrence. Indeed, CB1 receptors are all distributed in depression associated neuroanatomical structures and neural circuits. Both animal experiments and clinical studies have demonstrated that impairment of the ECS pathway is present in depression models and patients, and application of both CB1 receptor agonists and anandamide (cannabinoid-like substance) degradation inhibitors produce similar biochemical and behavioral effects as antidepressants...
August 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29434273/giant-and-tunable-optical-torque-for-micro-motors-by-increased-force-arm-and-resonantly-enhanced-force
#19
Yong Geng, Jiubin Tan, Yongyin Cao, Yixuan Zhao, Zhengjun Liu, Weiqiang Ding
Micro-motors driven by light field have attracted much attentions for their potential applications. In order to drive the rotation of a micro-motor, structured optical beams with orbital angular momentum, spin angular momentum, anisotropic medium, and/or inhomogeneous intensity distribution should be used. Even though, it is still challenge to increase the optical torques (OT) in a flexible and controllable way in case of moderate incident power. In this paper, a new scheme achieving giant optical torque is proposed by increasing both the force arm and the force amplitude with the assistance of a ring resonator...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29434037/changes-in-the-flagellar-bundling-time-account-for-variations-in-swimming-behavior-of-flagellated-bacteria-in-viscous-media
#20
Zijie Qu, Fatma Zeynep Temel, Rene Henderikx, Kenneth S Breuer
Although the motility of the flagellated bacteria, Escherichia coli, has been widely studied, the effect of viscosity on swimming speed remains controversial. The swimming mode of wild-type E. coli is often idealized as a run-and-tumble sequence in which periods of swimming at a constant speed are randomly interrupted by a sudden change of direction at a very low speed. Using a tracking microscope, we follow cells for extended periods of time in Newtonian liquids of varying viscosity and find that the swimming behavior of a single cell can exhibit a variety of behaviors, including run and tumble and "slow random walk" in which the cells move at a relatively low speed...
February 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
keyword
keyword
106525
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"