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frailty in olders

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https://www.readbyqxmd.com/read/28087677/incorporating-persistent-pain-in-phenotypic-frailty-measurement-and-prediction-of-adverse-health-outcomes
#1
Matthew C Lohman, Karen L Whiteman, Rebecca L Greenberg, Martha L Bruce
BACKGROUND: Frailty, a syndrome of physiological deficits, is prevalent among older adults and predicts elevated risk of adverse health outcomes. Although persistent pain predicts similar risk, it is seldom considered in frailty measurement. This article evaluated the construct and predictive validity of including persistent pain in phenotypic frailty measurement. METHODS: Frailty and persistent pain were operationalized using data from the Health and Retirement Study (2006-2012 waves)...
February 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28079633/criterion-referenced-values-of-grip-strength-and-usual-gait-speed-using-instrumental-activities-of-daily-living-disability-as-the-criterion
#2
Meng-Chih Lee, Chih-Cheng Hsu, Yi-Fen Tsai, Ching-Yu Chen, Cheng-Chieh Lin, Ching-Yi Wang
BACKGROUND AND PURPOSE: Current evidence suggests that grip strength and usual gait speed (UGS) are important predictors of instrumental activities of daily living (IADL) disability. Knowing the optimum cut points of these tests for discriminating people with and without IADL disability could help clinicians or researchers to better interpret the test results and make medical decisions. The purpose of this study was to determine the cutoff values of grip strength and UGS for best discriminating community-dwelling older adults with and without IADL disability, separately for men and women, and to investigate their association with IADL disability...
January 10, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28076861/potential-applications-of-smart-multifunctional-wearable-materials-to-gerontology
#3
David G Armstrong, Bijan Najafi, Mohsen Shahinpoor
Smart multifunctional materials can play a constructive role in addressing some very important aging-related issues. Aging affects the ability of older adults to continue to live safely and economically in their own residences for as long as possible. Thus, there will be a greater need for preventive, acute, rehabilitative, and long-term health care services for older adults as well as a need for tools to enable them to function independently during daily activities. The objective of this paper is, thus, to present a comprehensive review of some potential smart materials and their areas of applications to gerontology...
January 12, 2017: Gerontology
https://www.readbyqxmd.com/read/28064173/interventions-to-prevent-or-reduce-the-level-of-frailty-in-community-dwelling-older-adults-a-scoping-review-of-the-literature-and-international-policies
#4
REVIEW
Martine T E Puts, Samar Toubasi, Melissa K Andrew, Maureen C Ashe, Jenny Ploeg, Esther Atkinson, Ana Patricia Ayala, Angelique Roy, Miriam Rodríguez Monforte, Howard Bergman, Kathy McGilton
BACKGROUND: frailty impacts older adults' ability to recover from an acute illness, injuries and other stresses. Currently, a systematic synthesis of available interventions to prevent or reduce frailty does not exist. Therefore, we conducted a scoping review of interventions and international policies designed to prevent or reduce the level of frailty in community-dwelling older adults. METHODS AND ANALYSIS: we conducted a scoping review using the framework of Arksey and O'Malley. We systematically searched articles and grey literature to identify interventions and policies that aimed to prevent or reduce the level of frailty...
January 6, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28064172/effectiveness-of-an-intervention-to-prevent-frailty-in-pre-frail-community-dwelling-older-people-consulting-in-primary-care-a-randomised-controlled-trial
#5
M Serra-Prat, X Sist, R Domenich, L Jurado, A Saiz, A Roces, E Palomera, M Tarradelles, M Papiol
BACKGROUND: evidence on the effectiveness of interventions to prevent frailty is scarce. OBJECTIVE: to assess the effect of an intervention in preventing frailty progression in pre-frail older people. STUDY DESIGN: a randomised, open label, controlled trial with two parallel arms. POPULATION: community-dwelling pre-frail older people (≥70 years) consulting in primary care. INTERVENTION: nutritional assessment (and derivation to a Nutritional Unit for usual care in the event of nutritional risk) and a physical activity programme including aerobic exercise and a set of mixed strengthening, balance and coordination exercises CONTROL GROUP: patients receiving the usual care...
January 6, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28058551/modified-frailty-index-predicts-morbidity-and-mortality-after-pancreaticoduodenectomy
#6
Harveshp Mogal, Sarah A Vermilion, Rebecca Dodson, Fang-Chi Hsu, Russell Howerton, Perry Shen, Clancy J Clark
BACKGROUND: Pancreatic cancer is a disease of older adults, who may present with limited physiologic reserve. The authors hypothesized that a frailty index can predict postoperative outcomes after pancreaticoduodenectomy (PD). METHODS: All patients who underwent PD were identified in the 2005-2012 NSQIP Participant Use File. Patients undergoing emergency procedures, those with an American Society of Anesthesiologists (ASA) classification of five, and those with a diagnosis of preoperative sepsis were excluded from the study...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28058214/older-candidates-for-kidney-transplantation-who-to-refer-and-what-to-expect
#7
REVIEW
Beatrice P Concepcion, Rachel C Forbes, Heidi M Schaefer
The number of older end-stage renal disease patients being referred for kidney transplantation continues to increase. This rise is occurring alongside the continually increasing prevalence of older end-stage renal disease patients. Although older kidney transplant recipients have decreased patient and graft survival compared to younger patients, transplantation in this patient population is pursued due to the survival advantage that it confers over remaining on the deceased donor waiting list. The upper limit of age and the extent of comorbidity and frailty at which transplantation ceases to be advantageous is not known...
December 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/28053514/clinical-outcome-and-predictors-of-adverse-events-of-an-enhanced-older-adult-psychiatric-liaison-service-rapid-assessment-interface-and-discharge-newport
#8
Inderpal Singh, Priya Fernando, Jane Griffin, Chris Edwards, Kathryn Williamson, Patrick Chance
BACKGROUND: Hospitals are currently admitting an increasing number of older people, and more than one-third could have an underlying mental health problem. The existing Older Adult Mental Health (OAMH) liaison service was increasingly unable to meet the escalating needs of older and frail patients. Therefore, the service was modernized and enhanced on an "invest-to-save" principle to provide a prompt holistic assessment for older adults with mental health problems. The objective of this study was a service evaluation to appraise clinical outcome, minimize the length of stay, and measure the predictors of adverse outcomes to streamline this enhanced service...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28049446/a-cross-sectional-study-of-the-association-between-dynapenia-and-higher-level-functional-capacity-in-daily-living-in-community-dwelling-older-adults-in-japan
#9
Masaki Iwamura, Masao Kanauchi
BACKGROUND: There are many reports that dynapenia, sarcopenia and frailty each have associations with bodily function or with Instrumental Activities of Daily Living (IADL). However, studies that compare all three conditions and their effects on IADL are lacking. The purpose of this study is to examine associations of sarcopenia, frailty, and dynapenia with IADL. METHODS: Participants included 123 community-dwelling older adults (31 men, 92 women,) aged 65 years or older (75...
January 3, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28043934/sex-differences-in-frailty-a-systematic-review-and-meta-analysis
#10
REVIEW
E H Gordon, N M Peel, M Samanta, O Theou, S E Howlett, R E Hubbard
BACKGROUND: It is a well-described clinical phenomenon that females live longer than males, yet tend to experience greater levels of co-morbidity and disability. Females can therefore be considered both more frail (because they have poorer health status) and less frail (because they have a lower risk of mortality). This systematic review aimed to determine whether this ageing paradox is demonstrated when the Frailty Index (FI) is used to measure frailty. METHODS: Medline, EMBASE and CINAHL databases were searched for observational studies that measured FI and mortality in community-dwellers over 65years of age...
December 30, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/28043804/risk-factors-for-mild-cognitive-impairment-dementia-and-mortality-the-sydney-memory-and-ageing-study
#11
Darren M Lipnicki, John Crawford, Nicole A Kochan, Julian N Trollor, Brian Draper, Simone Reppermund, Kate Maston, Karen A Mather, Henry Brodaty, Perminder S Sachdev
BACKGROUND: The nature and commonality of late-life risk factors for mild cognitive impairment (MCI), dementia, and mortality remain unclear. Our aim was to investigate potential risk factors, simultaneously in a single cohort including many individuals initially with normal cognition and followed for 6 years. METHODS: We classified 873 community-dwelling individuals (70-90 years old and without dementia at baseline) from the Sydney Memory and Ageing Study as cognitively normal (CN), having MCI or dementia, or deceased 6 years after baseline...
December 31, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28042985/enhancing-elderly-health-examination-effectiveness-by-adding-physical-function-evaluations-and-interventions
#12
Chia-Ming Li, Ching-I Chang, Wen-Ruey Yu, Winnie Yang, Chih-Cheng Hsu, Ching-Yu Chen
This study aimed to assess the benefit of adding physical function evaluations and interventions to routine elderly health examination. This is a Quasi-experimental controlled trial. 404 elderly adults (aged 70 and over) scoring 3-6 on the Canadian Study of Health and Aging Clinical Frailty Scale Chinese In-Person Interview Version (CSHA-CFS) in a 2012 annual elderly health examination were enrolled. Both the control and experimental groups received the routine annual health examination with the latter further provided with functional evaluations, exercise instruction, and nutrition education...
December 24, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28035339/emerging-roles-for-histone-deacetylases-in-age-related-muscle-atrophy
#13
REVIEW
Michael E Walsh, Holly Van Remmen
BACKGROUND: Skeletal muscle atrophy during aging, a process known as sarcopenia, is associated with muscle weakness, frailty, and the loss of independence in older adults. The mechanisms contributing to sarcopenia are not totally understood, but muscle fiber loss due to apoptosis, reduced stimulation of anabolic pathways, activation of catabolic pathways, denervation, and altered metabolism have been observed in muscle from old rodents and humans. OBJECTIVE: Recently, histone deacetylases (HDACs) have been implicated in muscle atrophy and dysfunction due to denervation, muscular dystrophy, and disuse, and HDACs play key roles in regulating metabolism in skeletal muscle...
October 27, 2016: Nutr Healthy Aging
https://www.readbyqxmd.com/read/28031949/the-effect-of-frailty-should-be-considered-in-the-management-plan-of-older-people-with-type-2-diabetes
#14
REVIEW
Ahmed H Abdelhafiz, Luan Koay, Alan J Sinclair
The prevalence of diabetes is increasing especially in older age due to increased life expectancy. In old age, diabetes is associated with high comorbidity burden and increased prevalence of geriatric syndromes including frailty in addition to micro- and macro-vascular complications. The emergence of frailty may change the natural history of Type 2 diabetes from a progressive to a regressive course with increased risk of hypoglycemia. This may result in normalization of blood glucose levels and lead to a state of burnt-out diabetes in frail older people with significant weight loss...
March 2016: Future Science OA
https://www.readbyqxmd.com/read/28030710/association-of-radiologic-indicators-of-frailty-with-1-year-mortality-in-older-trauma-patients-opportunistic-screening-for-sarcopenia-and-osteopenia
#15
Stephen J Kaplan, Tam N Pham, Saman Arbabi, Joel A Gross, Mamatha Damodarasamy, Itay Bentov, Lisa A Taitsman, Steven H Mitchell, May J Reed
Importance: Assessment of physical frailty in older trauma patients admitted to the intensive care unit is often not feasible using traditional frailty assessment instruments. The use of opportunistic computed tomography (CT) scans to assess sarcopenia and osteopenia as indicators of underlying frailty may provide complementary prognostic information on long-term outcomes. Objective: To determine whether sarcopenia and/or osteopenia are associated with 1-year mortality in an older trauma patient population...
December 28, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/28029569/key-elements-of-optimal-treatment-decision-making-for-surgeons-and-older-patients-with-colorectal-or-pancreatic-cancer-a-qualitative-study
#16
Noralie H Geessink, Yvonne Schoon, Hanneke C P van Herk, Harry van Goor, Marcel G M Olde Rikkert
OBJECTIVE: To identify key elements of optimal treatment decision-making for surgeons and older patients with colorectal (CRC) or pancreatic cancer (PC). METHODS: Six focus groups with different participants were performed: three with older CRC/PC patients and relatives, and three with physicians. Supplementary in-depth interviews were conducted in another seven patients. Framework analysis was used to identify key elements in decision-making. RESULTS: 23 physicians, 22 patients and 14 relatives participated...
October 17, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/28029078/nutrition-and-exercise-in-sarcopenia
#17
Stephen D Anton, Azumi Hida, Robert Mankowski, Andrew Layne, Lawrence Solberg, Arch G Mainous, Thomas W Buford
Sarcopenia is a debilitating condition that involves loss of muscle mass and function, which affects virtually everyone as they age, and can lead to frailty and ultimately disability. In growing recognition of the importance of both muscle strength and muscle mass relative to body size in contributing to functional decline, recent definitions have now incorporated grip strength and a correction for body mass as part of the key criteria that define sarcopenia. With this new definition, a much larger population of older adults are now at risk of sarcopenia...
December 27, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28028838/long-term-tooth-retention-in-chronic-periodontitis-results-after-18-years-of-a-conservative-periodontal-treatment-regimen-in-a-university-setting
#18
Christian Graetz, Anna Plaumann, Peter Schlattmann, Maren Kahl, Claudia Springer, Sonja Sälzer, Konstantin Gomer, Christof Dörfer, Falk Schwendicke
AIM: The longitudinal study assessed the risk of tooth loss under a non-regenerative treatment regimen, and aimed to identify prognostic factors for tooth loss. METHODS: 315 patients (8009 teeth) were examined before (T0) and after active periodontal therapy (APT, T1) as well as after (mean±SD) 18±6 years of supportive periodontal therapy (SPT, T2). Descriptive statistics and a Cox-proportional-hazards shared-frailty model were applied. RESULTS: Overall, 351 and 816 teeth were lost during APT and SPT, respectively, with 0...
December 27, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28024721/functional-and-cognitive-impairment-social-environment-frailty-and-adverse-health-outcomes-in-older-patients-with-head-and-neck-cancer-a-systematic-review
#19
REVIEW
Floor J van Deudekom, Anouk S Schimberg, Marije H Kallenberg, Marije Slingerland, Lily-Ann van der Velden, Simon P Mooijaart
OBJECTIVES: Older head and neck cancer patients are at increased risk for adverse health outcomes, but little is known about which geriatric assessment associates with poor outcome. The aim is to study the association of functional or cognitive impairment, social environment and frailty with adverse health outcomes in patients with head and neck cancer. METHODS: Four libraries were searched for studies reporting on an association of functional or cognitive impairment, social environment and frailty with adverse outcomes in head and neck cancer patients...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28024089/is-polypharmacy-associated-with-frailty-in-older-people-results-from-the-esther-cohort-study
#20
Kai-Uwe Saum, Ben Schöttker, Andreas D Meid, Bernd Holleczek, Walter E Haefeli, Klaus Hauer, Hermann Brenner
OBJECTIVES: To investigate the relationship between polypharmacy and frailty. DESIGN: Longitudinal, observational cohort study. SETTING: Saarland, Germany. PARTICIPANTS: 3,058 community-dwelling adults aged between 57 and 84 years. MEASUREMENTS: Frailty was assessed according to the frailty phenotype, described by Fried et al. Polypharmacy and hyperpolypharmacy were defined as the concomitant use of five or more and 10 or more drugs, respectively...
December 26, 2016: Journal of the American Geriatrics Society
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