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frailty in olders

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https://www.readbyqxmd.com/read/29781555/dependence-on-others-for-oral-hygiene-and-its-association-with-hand-deformities-and-functional-impairment-in-elders-with-a-history-of-leprosy
#1
Raquel Conceição Ferreira, Talita Xavier Gonçalves, Anna Rachel Dos Santos Soares, Luísa Rodrigues de Abreu Carvalho, Fernanda Lamounier Campos, Marco Túlio de Freitas Ribeiro, Andrea Maria Eleutério de Barros Lima Martins, Efigênia Ferreira E Ferreira
OBJECTIVE: To analyse the frequency of dependence on others for oral hygiene and its association with hand deformities, frailty and dependence on others for basic activities of daily living (BADL) among elders with a history of leprosy. BACKGROUND: Dependence on others for oral hygiene has not been considered in multifunctional geriatric assessments. MATERIAL AND METHODS: Edentulous elders with a history of leprosy who used complete dentures and resided in a former leprosy colony were classified as independent or partially/completely dependent on others for brushing their dentures or rinsing and for BADL, and as frail or robust...
May 21, 2018: Gerodontology
https://www.readbyqxmd.com/read/29778652/frailty-and-diabetes-among-mexican-american-older-adults
#2
Bret T Howrey, Soham Al Snih, Kyriakos S Markides, Kenneth J Ottenbacher
PURPOSE: Progressive physical frailty in older adults is associated with increased risk of falls, disability, institutionalization, and mortality. Although associations between diabetes and frailty have been observed, the impact of diabetes on frailty in older Hispanics is largely unexplored. We examine the association of diabetes on the odds of frailty among older Mexican Americans. METHODS: Using data from the Hispanic Established Population for the Epidemiological Study of the Elderly from 1995 until 2012, frailty was assessed by slow gait, weak hand grip strength, exhaustion, and unexplained weight loss (n = 1327)...
April 26, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29778642/benefits-of-a-multicomponent-falls-unit-based-exercise-program-in-older-adults-with-falls-in-real-life
#3
Rafael García Molina, Marta Carolina Ruíz Grao, Alicia Noguerón García, Marta Martínez Reig, Mariano Esbrí Víctor, Míkel Izquierdo Redín, Pedro Abizanda Soler
BACKGROUND/OBJECTIVES: Multicomponent exercise programs are the cornerstone in preventing gait and balance impairments and falls in older adults. However, the effects of these programs in usual clinical practice have been poorly analyzed. DESIGN: 4-Month, twice-a-week multicomponent exercise program cohort study in real-life. SETTING: Falls Unit, Complejo Hospitalario Universitario of Albacete, Spain. PARTICIPANTS: Sixty-seven participants who had experienced a fall in the previous year were included...
May 17, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29777975/geriatric-analysis-from-prodige-20-randomized-phase-ii-trial-evaluating-bevacizumab-chemotherapy-versus-chemotherapy-alone-in-older-patients-with-untreated-metastatic-colorectal-cancer
#4
T Aparicio, O Bouché, E Francois, F Retornaz, E Barbier, J Taieb, S Kirscher, P-L Etienne, R Faroux, F Khemissa Akouz, F El Hajbi, C Locher, Y Rinaldi, T Lecomte, S Lavau-Denes, M Baconnier, A Oden-Gangloff, D Genet, L Bedenne, E Paillaud
BACKGROUND: Older patients have frailty characteristics that impair the transposition of treatment results found in younger patients. Predictive factors are needed to help with treatment choices for older patients. The PRODIGE 20 study is a randomized phase II study that evaluated chemotherapy associated with bevacizumab (BEV) or not (CT) in patients aged 75 years or older. PATIENTS AND METHODS: Patients underwent a geriatric assessment at randomization and at each evaluation...
May 16, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29777549/frailty-risk-in-hospitalized-older-adults-with-and-without-diabetes-mellitus
#5
Deborah A Lekan, Thomas P McCoy
BACKGROUND: Research indicates that diabetes mellitus (DM) may be a risk factor for frailty and individuals with DM are more likely to be frail than individuals without DM, however, there is limited research in hospitalized older adults. OBJECTIVES: To determine the extent of frailty in hospitalized older adults with and without DM using a 16-item Frailty Risk Score (FRS) and assess the role of frailty in predicting 30-day rehospitalization, discharge to an institution, and in-hospital mortality...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29777476/comparison-of-procalcitonin-a-potentially-new-inflammatory-biomarker-of-frailty-to-interleukin-6-and-c-reactive-protein-among-older-chinese-hospitalized-patients
#6
Ying Yang, Qiukui Hao, Joseph H Flaherty, Li Cao, Jianghua Zhou, Li Su, Yanjiao Shen, Birong Dong
AIM: Procalcitonin (PCT) has predictive value for patients with infectious diseases, but has not been studied in frailty. The purpose of this study was to compare PCT to two other inflammatory biomarkers [interleukin-6 (IL-6)] and C-reactive protein (CRP) in their association with frailty among older hospitalized patients. METHODS: Retrospective study of inpatients (June-December, 2016), who had all three biomarkers measured within 24 h of admission. Frailty was defined according to the Chinese version of a validated frailty scale...
May 17, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29775746/anthropometric-measurements-and-mortality-in-frail-older-adults
#7
Jonathan F Easton, Christopher R Stephens, Heriberto Román-Sicilia, Matteo Cesari, Mario Ulises Pérez-Zepeda
BACKGROUND: As the number of older adults increases, so does the number of frail older adults. Although anthropometry has been widely used as a way to stratify the overall mortality risk of a person, the significance of these measurements becomes blurred in the case of frail older adults who have changes in body composition. Therefore, the aim of this study is to determine the association of anthropometric measurements (body mass index, knee-adjusted height body mass index, waist-to-hip ratio and calf circumference) with mortality risk in a group of older Mexican adults...
May 15, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29774388/withholding-or-withdrawing-of-life-sustaining-therapy-in-older-adults-%C3%A2-80-years-admitted-to-the-intensive-care-unit
#8
Bertrand Guidet, Hans Flaatten, Ariane Boumendil, Alessandro Morandi, Finn H Andersen, Antonio Artigas, Guido Bertolini, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno, Sandra Oeyen, Christina Agwald Öhman, Bernardo Bollen Pinto, Ivo W Soliman, Wojciech Szczeklik, Andreas Valentin, Ximena Watson, Tilemachos Zafeiridis, Dylan W De Lange
PURPOSE: To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU. METHODS: This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up. RESULTS: LST limitation was identified in 1356/5021 (27.2%) of patients: 15% had a withholding decision and 12.2% a withdrawal decision (including those with a previous withholding decision)...
May 17, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29774369/-effectiveness-of-active-health-promotion-in-old-age-results-regarding-compression-of-morbidity-by-target-groups-in-13-8-years-of-observation-in-lucas
#9
REVIEW
Ulrike Dapp, Christoph Minder, Lilli Neumann, Stefan Golgert, Björn Klugmann, Wolfgang von Renteln-Kruse
BACKGROUND AND OBJECTIVE: Healthy ageing as defined by the World Health Organization (WHO) is the development and maintenance of functional competence. Unfavourable ageing is described by the term frailty and is characterised by a decline in functional reserves. The frailty process can be influenced in a positive way. Previous interventions concerned mostly hospital patients and residents of nursing homes. In this study we examined the maintenance of functional competence in an urban community setting...
May 17, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29773704/effect-of-dietary-omega-3-fatty-acid-supplementation-on-frailty-related-phenotypes-in-older-adults-a-systematic-review-and-meta-analysis-protocol
#10
Joanne Stocks, Ana M Valdes
INTRODUCTION: The beneficial effect of dietary omega-3 supplementation in younger adults or older people with acute or chronic disease is established. Knowledge is now needed about the effect in medically stable older people. The objective of this study is to examine and assess the evidence for a role of dietary omega-3 polyunsaturated fatty acid (PUFA) supplementation in older adults on (1) muscle mass and muscle strength, (2) inflammatory biomarkers and (3) physical activity. METHODS AND ANALYSIS: A systematic review and data synthesis will be conducted of randomised controlled trials in older people not recruited for any given disease diagnosis...
May 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29772594/-upper-age-limit-in-outpatient-anesthesia-opportunities-and-risks
#11
Tobias Hüppe, Nicole Kneller, Alexander Raddatz
Ambulatory surgery in elderly patients continues to increase - avoiding hospitalization and thus postoperative cognitive dysfunction in older patients being its major objectives. An upper age limit in outpatient anesthesia does not exist to date. However, functional rather than chronological age is crucial in patient selection. In consensus discussion, baseline functional status should be evaluated regularly - defined as everyday behaviors necessary to maintain daily life and encompassing areas of physical, cognitive, and social functioning...
May 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29770839/are-multidose-drug-dispensing-systems-initiated-for-the-appropriate-patients
#12
Bram J Mertens, H F Kwint, Rob J van Marum, Marcel L Bouvy
PURPOSE: It is unknown if multidose drug dispensing (MDD) systems are initiated for the appropriate patients. Therefore, the objective of this study was to compare the medication management problems of patients who were about to start with a MDD system (MDD patients) and patients who continued manually dispensed medication (non-MDD users) in order to identify if the appropriate patients receive a MDD system. METHODS: Patient interviews (semi-structured) were conducted by 44 community pharmacists at the patient's home...
May 16, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29769749/reference-values-for-body-composition-and-associations-with-blood-pressure-in-kenyan-adults-aged-%C3%A2-50-years-old
#13
Madeleine C Bastawrous, Carmen Piernas, Andrew Bastawrous, Jason Oke, Daniel Lasserson, Wanjiku Mathenge, Matthew J Burton, Susan A Jebb, Hannah Kuper
BACKGROUND/OBJECTIVES: To develop age- and sex-specific centile reference curves for fat-free mass (FFM) and fat mass (FM) adjusted for height in an adult Kenyan population and to investigate the association between FM, FFM and blood pressure (BP). SUBJECTS/METHODS: Measures of body composition from bioimpedance analyses and BP were collected in 1995 participants aged ≥50 years in Nakuru County, Kenya. Reference curves were produced using the LMS method. Multivariable linear regression models were used to test the cross-sectional association between body composition indexes and BP...
May 15, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29765957/genetic-insights-into-frailty-association-of-9p21-23-locus-with-frailty
#14
Sanish Sathyan, Nir Barzilai, Gil Atzmon, Sofiya Milman, Emmeline Ayers, Joe Verghese
Frailty is a complex aging phenotype associated with increased vulnerability to disability and death. Understanding the biological antecedents of frailty may provide clues to healthy aging. The genome-wide association study hotspot, 9p21-23 region, is a risk locus for a number of age-related complex disorders associated with frailty. Hence, we conducted an association study to examine whether variations in 9p21-23 locus plays a role in the pathogenesis of frailty in 637 community-dwelling Ashkenazi Jewish adults aged 65 and older enrolled in the LonGenity study...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29764723/frailty-assessment-to-help-predict-patients-at-risk-of-delirium-when-consulting-the-emergency-department
#15
Marianne Giroux, Marie-Josée Sirois, Valérie Boucher, Raoul Daoust, Émilie Gouin, Mathieu Pelletier, Simon Berthelot, Philippe Voyer, Marcel Émond
BACKGROUND: Delirium is underdiagnosed in seniors at emergency departments (EDs) even though it is a frequent complication and is associated with functional and cognitive decline. As frailty is an independent predictor of adverse events in seniors, screening for frailty in EDs may help identify those at risk of delirium. OBJECTIVES: To assess if screening older patients for frailty in EDs could help identify those at risk of delirium. METHODOLOGY: This study was part of the multicenter prospective cohort INDEED study...
May 12, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29762317/corrigendum-effectiveness-of-interventions-to-prevent-pre-frailty-and-frailty-progression-in-older-adults-a-systematic-review
#16
João Apóstolo, Richard Cooke, Elzbieta Bobrowicz-Campos, Silvina Santana, Maura Marcucci, Antonio Cano, Miriam Vollenbroek-Hutten, Federico Germini, Barbara D'Avanzo, Holly Gwyther, Carol Holland
No abstract text is available yet for this article.
May 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29761132/the-risk-factors-of-performance-based-early-frailty-in-midlife-and-older-age
#17
Matthew J Peterson
Background: Identifying impairments prior to onset of physical frailty may inform targeted interventions. An objective, clinically feasible early frailty measure, termed performance-based early frailty (PBEF) was developed, and antecedent and current risk factors were examined. Method: Data were from N = 104 participants of the Fels Longitudinal Study. PBEF was derived from age-specific cut points for time to complete five chair stands and walk four meters. "Pre-PBEF" and "PBEF" were defined as impairment in one or both measures, respectively...
January 2018: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29760608/calf-circumference-as-a-simple-screening-marker-for-diagnosing-sarcopenia-in-older-korean-adults-the-korean-frailty-and-aging-cohort-study-kfacs
#18
Sunyoung Kim, Miji Kim, Yunhwan Lee, ByungSung Kim, Tai Young Yoon, Chang Won Won
Background: The purpose of this study was to explore the optimal cut-off point of calf circumference (CC) as a simple proxy marker of appendicular skeletal muscle mass (ASM) and sarcopenia in the Korean elderly and to test the criterion-related validity of CC by analyzing its relationships with the physical function. Methods: The participants were 657 adults aged 70 to 84 years who had completed both dual energy X-ray absorptiometry (DXA) and physical function test in the first baseline year of the Korean Frailty and Aging Cohort Study...
May 14, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29759070/identifying-frailty-in-primary-care-a-qualitative-description-of-family-physicians-gestalt-impressions-of-their-older-adult-patients
#19
Clara Korenvain, Ida-Maisie Famiyeh, Sheila Dunn, Cynthia R Whitehead, Paula A Rochon, Lisa M McCarthy
BACKGROUND: Many tools exist to guide family physicians' impressions about frailty status of older adults, but no single tool, instrument, or set of criteria has emerged as most useful. The role of physicians' subjective impressions in frailty decisions has not been studied. This study explores how family physicians conceptualize frailty, and the factors that they consider when making subjective decisions about patients' frailty statuses. METHODS: Descriptive qualitative study of family physicians who practice in a large urban academic family medicine center as they participated in one-on-one "think-aloud" interviews about the frailty status of their patients aged 80 years and over...
May 14, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29753582/the-biomarkers-associated-with-sarcopenia-and-physical-frailty-in-elderly-persons-biosphere-study-rationale-design-and-methods
#20
Riccardo Calvani, Anna Picca, Federico Marini, Alessandra Biancolillo, Matteo Cesari, Vito Pesce, Angela Maria Serena Lezza, Maurizio Bossola, Christiaan Leeuwenburgh, Roberto Bernabei, Francesco Landi, Emanuele Marzetti
Sarcopenia, the progressive and generalised loss of muscle mass and strength/function, is a major health issue in older adults given its high prevalence and burdensome clinical implications. Over the years, this condition has been endorsed as a marker for discriminating biological from chronological age. However, the absence of a unified operational definition has hampered its full appreciation by healthcare providers, researchers and policy-makers. In addition to this unsolved debate, the complexity of musculoskeletal ageing represents a major challenge to the identification of clinically meaningful biomarkers...
May 10, 2018: European Journal of Internal Medicine
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