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frailty in olders

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https://www.readbyqxmd.com/read/28647579/frailty-is-associated-with-lower-expression-of-genes-involved-in-cellular-response-to-stress-results-from-the-toledo-study-for-healthy-aging
#1
Mariam El Assar, Javier Angulo, José Antonio Carnicero, Stefan Walter, Francisco José García-García, Eva López-Hernández, José-María Sánchez-Puelles, Leocadio Rodríguez-Mañas
BACKGROUND: Specific mechanisms underlying frailty syndrome are not well known. Frailty can be viewed as a loss of functional reserve resulting in increased vulnerability to stressors. We hypothesize that pathways regulating cellular response to stress are potential players in the development of frailty. The aim of this study was to evaluate the association of the expression of certain genes related to cellular response to stress with the presence of frailty in older patients. METHODS: A sample of 350 individuals aged 65 years or older (22% frail) was selected from the Toledo Study of Healthy Aging...
June 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28646457/national-survey-among-radiation-oncology-residents-related-to-their-needs-in-geriatric-oncology
#2
Rachel Leifer, Bonnie Bristow, Martine Puts, Shabbir Alibhai, Xingshan Cao, Barbara-Ann Millar, Meredith Giuliani, Tina Hsu, Maureen Trudeau, Rajin Mehta, Ines Menjak, Mireille Norris, Barbara Liu, Francois Gallant, Ewa Szumacher
Currently, there is no formal curriculum addressing geriatric oncology within Canadian radiation oncology (RO) residency programs. Knowledge related to geriatric medicine may help radiation oncologists modify RT based on frailty status and geriatric considerations. Understanding specific learning needs allow program coordinators to align the current curriculum with residents' geriatric oncology learning needs. The purpose of this study is to determine the geriatric oncology educational needs of the Canadian RO residents and to inform Canadian RO residency training...
June 24, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28641903/-effectiveness-of-physical-exercise-on-fitness-in-frail-older-adults-a-systematic-review-of-randomised-trials
#3
Maria Viladrosa, Carles Casanova, Angela Claudia Ghiorghies, Pilar Jürschik
Performing exercise to maintain a good physical condition is crucial to improve and prevent frailty in older adults. The aim of this review was to assess the beneficial effects of physical exercise on fitness in frail older adults. A thorough literature search of randomised clinical trials (RCT) in the last 15 years was performed on different electronic databases. The methodological assessment of studies was obtained using the PEDro scale. Ten RCT were included, providing a final sample of 1,130 individuals...
June 19, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28639340/impact-of-frailty-and-residual-subsyndromal-delirium-on-1-year-functional-recovery-a-prospective-cohort-study
#4
Justin Chew, Wee Shiong Lim, Mei Sian Chong, Yew Yoong Ding, Laura Tay
AIM: To investigate the association between frailty and incomplete delirium recovery at discharge (residual subsyndromal delirium [RSSD]), and to examine the mediating role of RSSD in the relationship between frailty and functional recovery at 12 months post-delirium. METHODS: This was a prospective observational study of 234 individuals aged ≥65 years admitted to a specialized delirium unit. A 20-item frailty index was derived using items from a comprehensive geriatric assessment...
June 22, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28639233/-physical-and-mental-dimensions-of-quality-of-life-of-frail-older-people
#5
Robbert J J Gobbens
Frail older people have an increased risk of limitations in performing activities of daily living, hospitalization, nursing home admission, and premature death. In this study we determined the difference in experiencing quality of life between frail and non-frail older people. We also investigated the associations between physical, psychological and social components of frailty and the physical and mental dimensions of quality of life. 374 people of 75 years and older filled in a questionnaire, the Senioren Barometer...
June 21, 2017: Tijdschrift Voor Gerontologie en Geriatrie
https://www.readbyqxmd.com/read/28633487/high-intensity-interval-training-hiit-improves-physical-performance-and-frailty-in-aged-mice
#6
Kenneth Ladd Seldeen, Ginger Lasky, Merced Maria Leiker, Manhui Pang, Kirkwood Ely Personius, Bruce Robert Troen
Sarcopenia and frailty are highly prevalent in older individuals, increasing the risk of disability and loss of independence. High intensity interval training (HIIT) may provide a robust intervention for both sarcopenia and frailty by achieving both strength and endurance benefits with lower time commitments than other exercise regimens. To better understand the impacts of HIIT during aging, we compared 24-month-old C57BL/6J sedentary mice with those that were administered 10-minute uphill treadmill HIIT sessions three times per week over 16 weeks...
June 17, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28633440/low-alanine-aminotransferase-levels-in-the-elderly-frailty-disability-sarcopenia-and-reduced-survival
#7
Umberto Vespasiani-Gentilucci, Antonio De Vincentis, Luigi Ferrucci, Stefania Bandinelli, Raffaele Antonelli Incalzi, Antonio Picardi
Background: Although low alanine aminotransferase (ALT) levels have been associated with poor outcomes in the elderly, the determinants subtending this association have been poorly explored. To gain insight into this topic, we analyzed data from a prospective population-based database (InCHIANTI study) in which frailty, disability, sarcopenia and pyridoxine levels were systematically assessed. Methods: Data are from 765 participants aged >65 years (mean age 75...
June 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28632933/patient-characteristics-associated-with-a-successful-response-to-nurse-led-care-programs-targeting-the-oldest-old-a-comparison-of-two-rcts
#8
Nienke Bleijenberg, Lorenz Imhof, Romy Mahrer-Imhof, Margaret I Wallhagen, Niek J de Wit, Marieke J Schuurmans
BACKGROUND: To improve the effectiveness of community-based care programs, especially those targeting the oldest-old population (80+), data are needed that elucidate those factors associated with a successful response to the intervention. Two comparable nurse-led care programs have been evaluated in two large randomized controlled trials (RCTs), one in Switzerland and one in the Netherlands. AIMS: To identify common patient characteristics that are related to a successful response to proactive nurse-led care, we explored if and to what extent, identical factors were present in both study populations...
June 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28632340/prescribing-in-the-oldest-old-inpatients-a-retrospective-analysis-of-patients-referred-for-specialist-geriatric-consultation
#9
Sivarajah Ilango, Peter Pillans, Nancye M Peel, Ian Scott, Leonard C Gray, Ruth E Hubbard
INTRODUCTION: While medications may prolong life and prevent morbidity in older people, adverse effects of polypharmacy are increasingly recognised. As patients age and become frail, prescribing may be expected to focus more on symptom control and minimise potentially harmful preventive medication use that confer little benefit within a short lifespan. Whether prescribing practice shifts to one of symptom control among the oldest old admitted to hospital remains unclear. METHODS: Retrospective analysis of all patients aged ≥85 years referred for comprehensive geriatric assessment at a tertiary care hospital between May 2006 and December 2014 for whom all prescribed medications were documented...
June 20, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28629899/high-adherence-to-a-mediterranean-diet-and-lower-risk-of-frailty-among-french-older-adults-community-dwellers-results-from-the-three-city-bordeaux-study
#10
Berna Rahi, Soufiane Ajana, Maturin Tabue-Teguo, Jean-François Dartigues, Karine Peres, Catherine Feart
BACKGROUND & AIMS: Mediterranean diet (MeDi) is considered as a key component for healthy aging, including prevention of age-related disability, while its association with frailty, independent of disability has never been assessed. Our objective was to investigate the relation between MeDi adherence and frailty incidence among persons aged ≥75 years participating at the prospective population-based French Three-City Study. METHODS: The study sample consisted of 560 initially non-frail participants of the Three-City-Bordeaux center, seen at the 2009-2010 follow-up, and re-examined two years later...
May 31, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28628498/earlier-physical-therapy-input-is-associated-with-a-reduced-length-of-hospital-stay-and-reduced-care-needs-on-discharge-in-frail-older-inpatients-an-observational-study
#11
Peter J Hartley, Victoria L Keevil, Ledia Alushi, Rebecca L Charles, Eimear B Conroy, Patricia M Costello, Becki Dixon, Aida M Dolinska-Grzybek, Diana Vajda, Roman Romero-Ortuno
BACKGROUND AND PURPOSE: Pressures on hospital bed occupancy in the English National Health Service have focused attention on enhanced service delivery models and methods by which physical therapists might contribute to effective cost savings, while retaining a patient-centered approach. Earlier access to physical therapy may lead to better outcomes in frail older inpatients, but this has not been well studied in acute National Health Service hospitals. Our aim was to retrospectively study the associations between early physical therapy input and length of hospital stay (LOS), functional outcomes, and care needs on discharge...
June 16, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28627050/effects-of-a-community-disability-prevention-program-for-frail-older-adults-at-48-month-follow-up
#12
Hyuma Makizako, Hiroyuki Shimada, Takehiko Doi, Kota Tsutumimoto, Daisuke Yoshida, Takao Suzuki
AIM: The present prospective study was carried out to determine whether participation in community-based intervention studies exerted a positive impact on disability prevention in older adults with physical frailty. METHODS: A total of 514 community-dwelling older adults (aged ≥65 years) with physical frailty who had undergone baseline assessment and participated in community-based intervention studies (participants) or did not (non-participants) were included in the present study...
June 18, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28625932/frailty-in-elderly-a-brief-review
#13
Maturin Tabue-Teguo, Nadine Simo, Magali Gonzalez-Colaço Harmand, Matteo Cesari, Jose-Alberto Avila-Funes, Catherine Féart, Hélène Amiéva, Jean-François Dartigues
The identification of frail older persons is a public health priority. Frailty is defined as an extreme vulnerability of the organism to endogenous and exogenous stressors, a syndrome that exposes the individual at higher risk of negative health-related outcomes as well as a transition phase between successful aging and disability. The theoretical concept of frailty is largely agreed, its practical translation still presents some limitations due to the existence of multiple tools and operational definition...
June 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28623152/singapore-healthy-older-people-everyday-hope-study-prevalence-of-frailty-and-associated-factors-in-older-adults
#14
Reshma A Merchant, Matthew Zhixuan Chen, Linda Wei Lin Tan, Moses YiDong Lim, Han Kwee Ho, Rob M van Dam
BACKGROUND: In the context of a rapidly ageing population, Singapore is anticipating a rise in multimorbidity, disability, and dependency, which are driven by physical frailty. Healthy Older People Everyday (HOPE) is an epidemiologic population-based study on community-dwelling older adults aged 65 years and older in Singapore. OBJECTIVE: To investigate the prevalence of frail and prefrail states and their association with polypharmacy, multimorbidity, cognitive and functional status, and perceived health status among community-dwelling older adults in Singapore...
June 13, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28623151/cognitive-performance-across-3-frailty-phenotypes-toledo-study-for-healthy-aging
#15
Cristina Rosado-Artalejo, Jose Antonio Carnicero, Jose Losa-Reyna, Amelia Guadalupe-Grau, Carmen Castillo-Gallego, Gonzalo Gutierrez-Avila, Ana Alfaro-Acha, Fernando Rodríguez-Artalejo, Leocadio Rodríguez-Mañas, Francisco José García-García
INTRODUCTION: Frailty is a strong predictor of adverse health events, but its impact on cognitive function is poorly understood. AIM: To assess cognitive performance in frailty and to identify the frailty stage where cognitive impairment begins. METHODS: Data were taken from 2044 people aged ≥65 years without cognitive impairment selected from the Toledo Study for Healthy Aging, a population-based cohort of older adults. Frailty status was assessed by 3 different scales: Frailty Phenotype (FP), Frailty Trait Scale (FTS), and Frailty Index (FI)...
June 13, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28618329/therapy-of-older-persons-with-acute-myeloid-leukaemia
#16
REVIEW
Utz Krug, Robert Peter Gale, Wolfgang E Berdel, Carsten Müller-Tidow, Matthias Stelljes, Klaus Metzeler, M Cristina Sauerland, Wolfgang Hiddemann, Thomas Büchner
Most persons age≥60 y with acute myeloid leukaemia (AML) die from their disease. When interpreting clinical trials data from these persons one must be aware of substantial selection biases. Randomized trials of post-remission treatments can be performed upfront or after achieving defined landmarks. Both strategies have important limitations. Selection of the appropriate treatment is critical. Age, performance score, co-morbidities and frailty provide useful data to treatment selection. If an intensive remission induction therapy is appropriate, therapy with cytarabine and an anthracycline is the most common regimen...
June 1, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28617837/risk-factors-and-protective-factors-associated-with-incident-or-increase-of-frailty-among-community-dwelling-older-adults-a-systematic-review-of-longitudinal-studies
#17
Zeyun Feng, Marjolein Lugtenberg, Carmen Franse, Xinye Fang, Shanlian Hu, Chunlin Jin, Hein Raat
INTRODUCTION: Frailty is one of the greatest challenges facing our aging population, as it can lead to adverse outcomes such as institutionalization, hospitalization, and mortality. However, the factors that are associated with frailty are poorly understood. We performed a systematic review of longitudinal studies in order to identify the sociodemographic, physical, biological, lifestyle-related, and psychological risk or protective factors that are associated with frailty among community-dwelling older adults...
2017: PloS One
https://www.readbyqxmd.com/read/28614455/absence-of-association-between-frailty-index-and-survival-in-elderly-brazilians-the-fibra-study
#18
Alexandre Alves Pereira, Flávia Silva Arbex Borim, Anita Liberalesso Neri
In Brazil, the frailty index has not been evaluated previously for its capacity to predict mortality in community-dwelling elderly. The objective of the current study was to evaluate the association between frailty index and mortality in the elderly. This was a prospective study consisting of data from the FIBRA Network-2008-2009 in Campinas, São Paulo State, with information on community-dwelling older adults from the urban area and through the Mortality Information System. Comparisons and statistical associations were performed with the following tests: Mann-Whitney, Kruskal-Wallis, chi-square, and Cox regression with 95% confidence intervals...
June 12, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28613287/geriatric-syndromes-and-not-cardiovascular-risk-factors-are-associated-with-cognitive-impairment-among-mexican-community-dwelling-elderly-with-type-2-diabetes
#19
Omar Yaxmehen Bello-Chavolla, Carlos Alberto Aguilar-Salinas, José Alberto Avila-Funes
BACKGROUND: The association of cognitive impairment and type 2 diabetes has been consistently shown in several studies, yet its association with geriatric syndromes has not been fully explored. OBJECTIVE: To study the correlates of cognitive impairment among community-dwelling elderly with type 2 diabetes. METHODS: Cross-sectional study of 135 diabetic persons aged 70 years or older participating in the Coyoacán Cohort Study in Mexico City...
May 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28605284/physical-activity-sedentary-time-and-frailty-in-older-migrant-women-from-ethnically-diverse-backgrounds-a-mixed-methods-study
#20
Diana Castaneda-Gameros, Sabi Redwood, Janice L Thompson
There is limited evidence examining the association between physical activity (PA), sedentary time (ST), frailty, and factors influencing PA behaviors in migrant older women from ethnically diverse backgrounds. The aims of this mixed-methods study were to: 1) examine PA levels and ST across frailty status; 2) identify any differences in PA/ST between ethnic and religious groups; and 3) qualitatively explore factors influencing PA among older (≥60 years) migrant women (n=60). PA/ST were assessed using accelerometry and frailty status using the frailty phenotype...
June 12, 2017: Journal of Aging and Physical Activity
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