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frailty in olders

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https://www.readbyqxmd.com/read/28737297/correlates-of-frailty-phenotype-and-frailty-index-and-their-associations-with-clinical-outcomes
#1
G Guaraldi, A Malagoli, O Theou, T D Brothers, Lmk Wallace, R Torelli, C Mussini, S Sartini, S A Kirkland, K Rockwood
OBJECTIVES: Frailty is a predictor of adverse health outcomes and can be measured across the life course, including among people living with HIV. The purpose of this study was to examine two commonly used measures of frailty - the frailty index (FI) and frailty phenotype - to assess common characteristics and to describe associations with multimorbidity, falls, and disability in people aging with HIV. METHODS: This was a cross-sectional observational study including 482 consecutive HIV-infected patients (mean age 53...
July 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28734173/reliability-and-validity-of-the-tilburg-frailty-indicator-tfi-among-chinese-community-dwelling-older-people
#2
Lijuan Dong, Na Liu, Xiaoyu Tian, Xiaoxia Qiao, Robbert J J Gobbens, Robert L Kane, Cuili Wang
OBJECTIVE: To translate the Tilburg Frailty Indicator (TFI) into Chinese and assess its reliability and validity. METHODS: A sample of 917 community-dwelling older people, aged ≥60 years, in a Chinese city was included between August 2015 and March 2016. Construct validity was assessed using alternative measures corresponding to the TFI items, including self-rated health status (SRH), unintentional weight loss, walking speed, timed-up-and-go tests (TUGT), making telephone calls, grip strength, exhaustion, Short Portable Mental Status Questionnaire (SPMSQ), Geriatric Depression scale (GDS-15), emotional role, Adaptability Partnership Growth Affection and Resolve scale (APGAR) and Social Support Rating Scale (SSRS)...
July 15, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28734043/enabling-reduction-of-low-grade-inflammation-in-seniors-pilot-study-concept-rationale-and-design
#3
Todd M Manini, Stephen D Anton, Daniel P Beavers, Jane A Cauley, Mark A Espeland, Roger A Fielding, Stephen B Kritchevsky, Christiaan Leeuwenburgh, Kristina H Lewis, Christine Liu, Mary M McDermott, Michael E Miller, Russell P Tracy, Jeremy D Walston, Barbara Radziszewska, Jane Lu, Cindy Stowe, Samuel Wu, Anne B Newman, Walter T Ambrosius, Marco Pahor
OBJECTIVES: To test two interventions to reduce interleukin (IL)-6 levels, an indicator of low-grade chronic inflammation and an independent risk factor for impaired mobility and slow walking speed in older adults. DESIGN: The ENabling Reduction of low-Grade Inflammation in SEniors (ENRGISE) Pilot Study was a multicenter, double-blind, placebo-controlled randomized pilot trial of two interventions to reduce IL-6 levels. SETTING: Five university-based research centers...
July 22, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28733716/osteosarcopenia-where-bone-muscle-and-fat-collide
#4
REVIEW
H P Hirschfeld, R Kinsella, G Duque
As the world's population ages, the prevalence of chronic diseases increases. Sarcopenia and osteoporosis are two conditions that are associated with aging, with similar risk factors that include genetics, endocrine function, and mechanical factors. Additionally, bone and muscle closely interact with each other not only anatomically, but also chemically and metabolically. Fat infiltration, a phenomenon observed in age-related bone and muscle loss, is highly prevalent and more severe in sarcopenic and osteoporotic subjects...
July 22, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28731943/the-impact-of-polypharmacy-on-patient-outcomes-in-older-adults-with-cancer
#5
Ginah Nightingale, Emily Skonecki, Manpreet K Boparai
Polypharmacy is prevalent in older adults with cancer and may be advantageous for the management of certain chronic disease states, but uncertainty exists regarding potential hazards and consequences. Cancer-related therapy adds to the prevalence of polypharmacy, which can lead to compromised cancer management plans (i.e., postoperative complications, treatment delays, and/or premature treatment discontinuation). Polypharmacy has been identified as one of the domains commonly included in the Comprehensive Geriatric Assessment likely because of the potential influence on health outcomes...
July 2017: Cancer Journal
https://www.readbyqxmd.com/read/28731537/frailty-and-cancer-implications-for-oncology-surgery-medical-oncology-and-radiation-oncology
#6
REVIEW
Cecilia G Ethun, Mehmet A Bilen, Ashesh B Jani, Shishir K Maithel, Kenneth Ogan, Viraj A Master
Answer questions and earn CME/CNE The concept of frailty has become increasingly recognized as one of the most important issues in health care and health outcomes and is of particular importance in patients with cancer who are receiving treatment with surgery, chemotherapy, and radiotherapy. Because both cancer itself, as well as the therapies offered, can be significant additional stressors that challenge a patient's physiologic reserve, the incidence of frailty in older patients with cancer is especially high-it is estimated that over one-half of older patients with cancer have frailty or prefrailty...
July 21, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28731422/frailty-in-men-living-with-hiv-a-cross-sectional-comparison-of-three-frailty-instruments
#7
Hui-Ling Yeoh, Allen Cheng, Clovis Palmer, Suzanne M Crowe, Jennifer F Hoy
BACKGROUND: Potent antiretroviral treatment has resulted in near normal life expectancy for people living with HIV. Consequently, there is an increased focus on comorbidities, frailty and quality of life. METHODS: We assessed and compared the prevalence of frailty, associated factors and relationship with quality of life in older Australian men living with HIV in a cross-sectional study using three frailty measurements. The Frailty Phenotype, Frailty Index, and Edmonton Frail Scale were applied to 93 HIV-infected men aged over 50 years, on antiretroviral therapy...
July 21, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28728570/health-promotion-interventions-for-community-dwelling-older-people-with-mild-or-pre-frailty-a-systematic-review-and-meta-analysis
#8
Rachael Frost, Celia Belk, Ana Jovicic, Federico Ricciardi, Kalpa Kharicha, Benjamin Gardner, Steve Iliffe, Claire Goodman, Jill Manthorpe, Vari M Drennan, Kate Walters
BACKGROUND: Mild or pre-frailty is common and associated with increased risks of hospitalisation, functional decline, moves to long-term care, and death. Little is known about the effectiveness of health promotion in reducing these risks. This systematic review aimed to synthesise randomised controlled trials (RCTs) evaluating home and community-based health promotion interventions for older people with mild/pre-frailty. METHODS: We searched 20 bibliographic databases and 3 trials registers (January 1990 - May 2016) using mild/pre-frailty and associated terms...
July 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28723916/stakeholders-views-and-experiences-of-care-and-interventions-for-addressing-frailty-and-pre-frailty-a-meta-synthesis-of-qualitative-evidence
#9
Barbara D'Avanzo, Rachel Shaw, Silvia Riva, Joao Apostolo, Elzbieta Bobrowicz-Campos, Donata Kurpas, Maria Bujnowska, Carol Holland
Frailty is a common condition in older age and is a public health concern which requires integrated care and involves different stakeholders. This meta-synthesis focuses on experiences, understanding, and attitudes towards screening, care, intervention and prevention for frailty across frail and healthy older persons, caregivers, health and social care practitioners. Studies published since 2001 were identified through search of electronic databases; 81 eligible papers were identified and read in full, and 45 papers were finally included and synthesized...
2017: PloS One
https://www.readbyqxmd.com/read/28721429/frailty-and-fear-of-falling-the-fistac-study
#10
M Esbrí-Víctor, I Huedo-Rodenas, M López-Utiel, J L Navarro-López, M Martínez-Reig, J A Serra-Rexach, L Romero-Rizos, P Abizanda
OBJECTIVE: To analyze the association between frailty and Fear of Falling (FoF) in a cohort of older adults with previous falls. DESIGN: Cross-sectional study (FISTAC). SETTING: Falls Unit, Complejo Hospitalario Universitario of Albacete (Spain). PARTICIPANTS: 183 adults older than 69 years, from the Falls Unit, with a history of a previous fall in the last year. MEASUREMENTS: FoF was assessed at baseline using the Falls Efficacy Scale International (FES-I) and three questions previously validated...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28721426/co-localization-of-macrophage-inhibitory-factor-and-nix-in-skeletal-muscle-of-the-aged-male-interleukin-10-null-mouse
#11
P Abadir, F Ko, R Marx, L Powell, E Kieserman, H Yang, J Walston
Chronic inflammation is associated with muscle weakness and frailty in older adults. The antagonistic cross-talk between macrophage migration inhibitory factor (Mif), an anti-apoptotic cytokine and NIP3-like protein X (Nix), a pro-apoptotic mitochondrial protein, may play a role in mitochondrial free radical homeostasis and inflammatory myopathies. We examined Nix-Mif interaction in inflammation and aging using young and old, IL-10tm/tm (a rodent model of chronic inflammation) and C57BL/6 mice. In this study, we observed that Nix and Mif were co-localized in skeletal muscles of aged and inflamed mice...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28721290/frailty-and-elderly-in-urology-is-there-an-impact-on-post-operative-complications
#12
Fabrizio Dal Moro, Alessandro Morlacco, Giovanni Motterle, Lisa Barbieri, Filiberto Zattoni
INTRODUCTION: Frailty used as predictive tool is still not carried out in daily practice, although many studies confirm the great clinical importance of the frailty syndrome in surgical outcomes. There is no standardized method of measuring the physiological reserves of older surgical patients. The aim of this study was to analyze a cohort of older urological patients according to various frailty indices, in order to evaluate whether they are predictors of post-operative complications after urological procedures...
June 30, 2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28721028/frailty-in-community-dwelling-older-adults-association-with-adverse-outcomes
#13
Sergio Sánchez-García, Carmen García-Peña, Antoni Salvà, Rosalinda Sánchez-Arenas, Víctor Granados-García, Juan Cuadros-Moreno, Laura Bárbara Velázquez-Olmedo, Ángel Cárdenas-Bahena
BACKGROUND: The study of frailty is important to identify the additional needs of medical long-term care and prevent adverse outcomes in community dwelling older adults. This study aimed to determine the prevalence of frailty and its association with adverse outcomes in community dwelling older adults. METHODS: A cross-sectional study was carried out from April to September 2014. The population sample was 1,252 older adults (≥60 years) who were beneficiaries of the Mexican Institute of Social Security (IMSS) in Mexico City...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28721027/frequency-of-frailty-and-its-association-with-cognitive-status-and-survival-in-older-chileans
#14
Cecilia Albala, Lydia Lera, Hugo Sanchez, Barbara Angel, Carlos Márquez, Patricia Arroyo, Patricio Fuentes
BACKGROUND: Age-associated brain physiologic decline and reduced mobility are key elements of increased age-associated vulnerability. OBJECTIVE: To study the frequency of frailty phenotype and its association with mental health and survival in older Chileans. METHODS: Follow-up of ALEXANDROS cohorts designed to study disability associated with obesity in community-dwelling people 60 years and older living in Santiago, Chile. At baseline, 2,098 (67% women) of 2,372 participants were identified as having the frailty phenotype: weak handgrip dynamometry, unintentional weight loss, fatigue/exhaustion, five chair-stands/slow walking speed and difficulty walking (low physical activity)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28718161/frailty-and-lower-urinary-tract-symptoms
#15
REVIEW
Anne M Suskind
The incidence of both frailty and lower urinary tract symptoms, including urinary incontinence, overactive bladder, underactive bladder, and benign prostatic hyperplasia, increases with age. However, our understanding of the relationship between frailty and lower urinary tract symptoms, both in terms of pathophysiology and in terms of the evaluation and management of such symptoms, is greatly lacking. This brief review will summarize definitions and measurement tools associated with frailty and will also review the existing state of the literature on frailty and lower urinary tract symptoms in older individuals...
September 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28717814/malnutrition-in-hospitalised-older-adults-a-multicentre-observational-study-of-prevalence-associations-and-outcomes
#16
E O'Shea, S Trawley, E Manning, A Barrett, V Browne, S Timmons
BACKGROUND: Malnutrition is common in older adults and is associated with high costs and adverse outcomes. The prevalence, predictors and outcomes of malnutrition on admission to hospital are not clear for this population. DESIGN: Prospective Cohort Study. SETTING: Six hospital sites (five public, one private). PARTICIPANTS: In total, 606 older adults aged 70+ were included. All elective and acute admissions to any speciality were eligible...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28712144/frailty-is-an-independent-prognostic-marker-in-elderly-patients-with-myocardial-infarction
#17
Gonzalo Luis Alonso Salinas, Marcelo Sanmartin, Marina Pascual Izco, Luis Miguel Rincon, Pablo Pastor Pueyo, Alvaro Marco Del Castillo, Alberto Garcia Guerrero, Pedro Caravaca Perez, Alejandro Recio-Mayoral, Asuncion Camino, Manuel Jimenez-Mena, José Luis Zamorano
BACKGROUND: Acute coronary syndrome (ACS) patients are increasingly older. Conventional prognostic scales include chronological age but do not consider vulnerability. In elderly patients, a frail phenotype represents a better reflection of biological age. HYPOTHESIS: This study aims to determine the prevalence of frailty and its influence on patients age ≥75 years with ACS. METHODS: Patients age ≥75 years admitted due to type 1 myocardial infarction were included in 2 tertiary hospitals, and clinical data were collected prospectively...
July 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28705733/platelet-oxidative-stress-as-a-novel-target-of-cardiovascular-risk-in-frail-older-people
#18
REVIEW
Francisco Fuentes, Iván Palomo, Eduardo Fuentes
The average lifespan of humans and the percentage of people entering the 65 and older age group are growing rapidly. Within this age group, cardiovascular diseases (CVD) increase steeply and are the most common cause of death. During aging, experimental and clinical studies support the pivotal role played by reactive oxidant species in the mechanism of platelet activation. Frailty has been implicated as a causative and prognostic factor in patients with CVD. Oxidative stress is increased in frail older people, and may lead to accelerated aging and higher incidence of oxidative diseases such as CVD...
July 11, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28705220/the-role-of-sports-clubs-in-helping-older-people-to-stay-active-and-prevent-frailty-a-longitudinal-mediation-analysis
#19
Paul Watts, Elizabeth Webb, Gopalakrishnan Netuveli
BACKGROUND: Frailty is a common syndrome in older adults characterised by increased vulnerability to adverse health outcomes as a result of decline in functional and physiological measures. Frailty predicts a range of poor health and social outcomes and is associated with increased risk of hospital admission. The health benefits of sport and physical activity and the health risks of inactivity are well known. However, less is known about the role of sports clubs and physical activity in preventing and managing frailty in older adults...
July 14, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28705176/time-to-immunologic-recovery-and-determinant-factors-among-adults-who-initiated-art-in-felege-hiwot-referral-hospital-northwest-ethiopia
#20
Lemma Derseh Gezie, Kassahun Alemu Gelaye, Abebaw Gebeyehu Worku, Tadesse Awoke Ayele, Destaw Fetene Teshome
BACKGROUND: CD4 cells are the major targets for human immunodeficiency virus (HIV) and treatment with Antiretroviral Therapy (ART) influences the CD4 cell count of HIV patients. In addition to ART, the time required to reach normal range of CD4 counts (500 cells/mm(3)) can be affected by clinical, socio-demographic, and behavioral factors. This retrospective cohort study was conducted to determine the incidence of having the normal range of CD4 cell counts and factors that affect the time required to reach this normal range among adult HIV patients who initiated into ART...
July 14, 2017: BMC Research Notes
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