keyword
https://read.qxmd.com/read/38652805/a-tale-of-two-pumps-blue-light-and-abscisic-acid-alter-arabidopsis-leaf-hydraulics-via-bundle-sheath-cell-h%C3%A2-%C3%A2-atpases
#1
JOURNAL ARTICLE
Tanmayee Torne-Srivastava, Yael Grunwald, Ahan Dalal, Adi Yaaran, Menachem Moshelion, Nava Moran
The bundle sheath cell (BSC) layer tightly enveloping the xylem throughout the leaf is recognized as a major signal-perceiving "valve" in series with stomata, regulating leaf hydraulic conductance (Kleaf) and thereby radial water flow via the transpiring leaf. The BSC blue light (BL) signaling pathway increases Kleaf and the underlying BSC water permeability. Here, we explored the hypothesis that BSCs also harbor a Kleaf-downregulating signaling pathway related to the stress phytohormone abscisic acid (ABA)...
April 23, 2024: Plant Physiology
https://read.qxmd.com/read/38650611/pest-categorisation-of-crisicoccus-seruratus
#2
JOURNAL ARTICLE
Claude Bragard, Paula Baptista, Elisavet Chatzivassiliou, Francesco Di Serio, Paolo Gonthier, Josep Anton Jaques Miret, Annemarie Fejer Justesen, Christer Sven Magnusson, Panagiotis Milonas, Juan A Navas-Cortes, Stephen Parnell, Roel Potting, Philippe Lucien Reignault, Emilio Stefani, Hans-Hermann Thulke, Wopke Van der Werf, Antonio Vicent Civera, Jonathan Yuen, Lucia Zappalà, Jean-Claude Grégoire, Chris Malumphy, Spyridon Antonatos, Virag Kertesz, Dimitrios Papachristos, Oresteia Sfyra, Alan MacLeod
Following the commodity risk assessments of Acer palmatum plants grafted on A. davidii from China, in which Crisicoccus matsumotoi (Hemiptera: Pseudococcidae) was identified as a pest of possible concern, the European Commission requested the EFSA Panel on Plant Health to conduct a pest categorisation of C. matsumotoi for the territory of the European Union. Recent taxonomic revision of the genus Crisisoccus concluded that C. matsumotoi is a synonym of C. seruratus ; therefore, the categorisation will use the current valid name C...
April 2024: EFSA journal
https://read.qxmd.com/read/38641362/performance-evaluation-of-a-self-administered-point-of-care-test-for-anal-hpv-screening-in-prep-users-data-from-a-community-based-prep-service
#3
JOURNAL ARTICLE
Lorenzo Biasioli, Roberto Rossotti, Alessandro Tavelli, Anna De Bona, Camilla Tincati, Daniele Calzavara, Pietro Vinti, Chiara Baiguera, Federico D'Amico, Alice Nava, Roberto Repossi, Simona Bossolasco, Camilla Muccini, Giovanni Mulè, Daniele Tesoro, Antonella d'Arminio Monforte, Massimo Cernuschi
OBJECTIVES: In this study, we compared the performance of a self-administered point-of-care test (POCT) for anal human papillomavirus (HPV) screening with laboratory gold-standard test in pre-exposure prophylaxis (PrEP) users and evaluated its feasibility. METHODS: We enrolled PrEP users from a local community-based PrEP service. Each participant self-collected an anal swab to test anal HPV with a PCR POCT capable of detecting 14 high-risk HPV genotypes. Anonymous questionnaires on self-sampling feasibility were completed...
April 19, 2024: Sexually Transmitted Infections
https://read.qxmd.com/read/38635592/the-central-role-of-social-exclusion-when-representing-ethnic-minorities-and-its-association-with-intergroup-attitudes
#4
JOURNAL ARTICLE
María Sánchez-Castelló, Lucía López-Rodríguez, Marisol Navas, Anna Maria Meneghini, Sofia Morandini
A mixed-methods approach was used to analyze the social representations of four ethnic minorities in southern Spain. Following a between-subjects design, Spanish participants ( n  = 532) were assigned to evaluate either Romanian Roma, Spanish Roma, Moroccan, or Romanian non-Roma people, with a free-association task and scales of stereotypes, emotions, and behavioral tendencies. Results showed that Romanian Roma was the most devalued target, eliciting the worst representation and attitudes. The content analysis revealed that participants described minorities mainly in terms of social exclusion, culture, appearance, personality, opportunity seeking, stigmatization, and personalization/equality, with social exclusion being a key category associated with worst attitudes...
April 18, 2024: Journal of Social Psychology
https://read.qxmd.com/read/38634053/-ikzf1-plus-is-a-frequent-biomarker-of-adverse-prognosis-in-mexican-pediatric-patients-with-b-acute-lymphoblastic-leukemia
#5
JOURNAL ARTICLE
Joaquin Garcia-Solorio, Juan Carlos Núñez-Enriquez, Marco Jiménez-Olivares, Janet Flores-Lujano, Fernanda Flores-Espino, Carolina Molina-Garay, Alejandra Cervera, Diana Casique-Aguirre, José Gabriel Peñaloza-Gonzalez, Ma Del Rocío Baños-Lara, Ángel García-Soto, César Alejandro Galván-Díaz, Alberto Olaya-Vargas, Hilario Flores Aguilar, Minerva Mata-Rocha, Miguel Ángel Garrido-Hernández, Juan Carlos Solís-Poblano, Nuria Citlalli Luna-Silva, Lena Sarahi Cano-Cuapio, Pierre Mitchel Aristil-Chery, Fernando Herrera-Quezada, Karol Carrillo-Sanchez, Anallely Muñoz-Rivas, Luis Leonardo Flores-Lagunes, Elvia Cristina Mendoza-Caamal, Beatriz Eugenia Villegas-Torres, Vincent González-Osnaya, Elva Jiménez-Hernández, José Refugio Torres-Nava, Jorge Alfonso Martín-Trejo, María de Lourdes Gutiérrez-Rivera, Rosa Martha Espinosa-Elizondo, Laura Elizabeth Merino-Pasaye, María Luisa Pérez-Saldívar, Silvia Jiménez-Morales, Everardo Curiel-Quesada, Haydeé Rosas-Vargas, Juan Manuel Mejía-Arangure, Carmen Alaez-Verson
BACKGROUND: Recurrent genetic alterations contributing to leukemogenesis have been identified in pediatric B-cell Acute Lymphoblastic Leukemia (B-ALL), and some are useful for refining classification, prognosis, and treatment selection. IKZF1plus is a complex biomarker associated with a poor prognosis. It is characterized by IKZF1 deletion coexisting with PAX5 , CDKN2A/2B , or PAR1 region deletions. The mutational spectrum and clinical impact of these alterations have scarcely been explored in Mexican pediatric patients with B-ALL...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38631123/financial-toxicity-in-allogeneic-haematopoietic-stem-cell-transplant-patients-from-a-social-determinants-of-health-perspective
#6
JOURNAL ARTICLE
Rocío Navas Huerga, Isabel Salcedo de Diego, Carlos de Miguel Jiménez, Cristina Muñoz Martínez, Mi Kwon, Natalia Pedraza García, María Calbacho, Ana Royuela Vicente, Pilar Serrano Gallardo
PURPOSE: Financial toxicity (FT) refers to the subjective perception of financial distress resulting from objective economic strain due to illness, exerting a detrimental influence on health outcomes. This study aimed to describe FT among allogeneic haematopoietic stem cell transplant (allo-HSCT) recipients within a public health framework, employing a social determinants of health approach. METHODS: A multi-centre cross-sectional study involving adult allo-HSCT patients was conducted across three public hospitals in Madrid...
April 8, 2024: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://read.qxmd.com/read/38629095/cardiovascular-effect-of-preeclampsia-upon-offspring-development-are-pro-renin-renin-receptor-p-rr-and-gender-related
#7
JOURNAL ARTICLE
Lourdes Graciela Baeza-Pérez, Sandra Edith Cabrera-Becerra, Rodrigo Romero-Nava, Erika Ramos-Tovar, Maria Elena Hernández-Campos, Pedro López-Sánchez
OBJECTIVES: Preeclampsia (PE) is a complication of pregnancy that might increase progeny risk of cardiovascular and metabolic problems, mainly in males. Renin angiotensin aldosterone system is known to be involved. (Pro) renin/renin receptor ((P)RR) has been shown to participate in cardiovascular pathology. The aim of this work was to evaluate (P)RR expression and function upon cardiovascular and renal tissues from PE dams' offspring. MATERIALS AND METHODS: We used offspring from normal pregnant and preeclamptic rats, evaluating body, heart, aorta and kidney weight, length, and blood pressure along 3 months after birth...
2024: Iranian Journal of Basic Medical Sciences
https://read.qxmd.com/read/38627831/goodbye-hartmann-trial-a-prospective-international-multicenter-observational-study-on-the-current-use-of-a-surgical-procedure-developed-a-century-ago
#8
MULTICENTER STUDY
Gennaro Perrone, Mario Giuffrida, Fikri Abu-Zidan, Vitor F Kruger, Marco Livrini, Gabriele Luciano Petracca, Giorgio Rossi, Antonio Tarasconi, Brian W C A Tian, Elena Bonati, Ricardo Mentz, Federico N Mazzini, Juan P Campana, Elisabeth Gasser, Reinhold Kafka-Ritsch, Daniel M Felsenreich, Christopher Dawoud, Stefan Riss, Carlos Augusto Gomes, Felipe Couto Gomes, Ricardo Alessandro Teixeira Gonzaga, Cassio Alfred Brattig Canton, Bruno Monteiro Pereira, Gustavo P Fraga, Leticia Gonçalves Zem, Vinicius Cordeiro-Fonseca, Renato de Mesquita Tauil, Boyko Atanasov, Nikolay Belev, Nikola Kovachev, L Juan José Meléndez, Ana Dimova, Stefan Dimov, Zdravko Zelić, Goran Augustin, Branko Bogdanić, Trpimir Morić, Elie Chouillard, Melinda Bajul, Belinda De Simone, Yves Panis, Francesco Esposito, Margherita Notarnicola, Lelde Lauka, Anna Fabbri, Hassen Hentati, Iskander Fnaiech, Venara Aurélien, Marie Bougard, Maxime Roulet, Zaza Demetrashvili, Irakli Pipia, Giorgi Merabishvili, Konstantinos Bouliaris, Georgios Koukoulis, Christos Doudakmanis, Sofia Xenaki, Emmanuel Chrysos, Stamatios Kokkinakis, Panteleimon Vassiliu, Nikolaos Michalopoulos, Ioannis Margaris, Aristotelis Kechagias, Konstantinos Avgerinos, Jevgeni Katunin, Eftychios Lostoridis, Eleni-Aikaterini Nagorni, Antonio Pujante, Francesk Mulita, Ioannis Maroulis, Michail Vailas, Athanasios Marinis, Ioannis Siannis, Eirini Bourbouteli, Dimitrios K Manatakis, Nikolaos Tasis, Vasileios Acheimastos, Sotiropoulou Maria, Kapiris Stylianos, Harilaos Kuzeridis, Dimitrios Korkolis, Evangelos Fradelos, George Kavalieratos, Thalia Petropoulou, Andreas Polydorou, Ioannis Papacostantinou, Tania Triantafyllou, Despina Kimpizi, Dimitrios Theodorou, Konstantinos Toutouzas, Alexandros Chamzin, Maximos Frountzas, Dimitrios Schizas, Ioannis Karavokyros, Athanasios Syllaios, Alexandros Charalabopoulos, Maria Boura, Efstratia Baili, Orestis Ioannidis, Lydia Loutzidou, Elissavet Anestiadou, Ioannis Tsouknidas, Georgios Petrakis, Eleni Polenta, Lovenish Bains, Rahul Gupta, Sudhir K Singh, Archana Khanduri, Miklosh Bala, Asaf Kedar, Marcello Pisano, Mauro Podda, Adolfo Pisanu, Gennaro Martines, Giuseppe Trigiante, Giuliano Lantone, Antonino Agrusa, Giuseppe Di Buono, Salvatore Buscemi, Massimiliano Veroux, Rossella Gioco, Gastone Veroux, Luigi Oragano, Sandro Zonta, Federico Lovisetto, Carlo V Feo, Antonio Pesce, Nicolò Fabbri, Giulio Lantone, Fabio Marino, Fabrizio Perrone, Leonardo Vincenti, Vincenzo Papagni, Arcangelo Picciariello, Stefano Rossi, Biagio Picardi, Simone Rossi Del Monte, Diego Visconti, Giulia Osella, Luca Petruzzelli, Giusto Pignata, Jacopo Andreuccetti, Rossella D'Alessio, Massimo Buonfantino, Eleonora Guaitoli, Stefano Spinelli, Gianluca Matteo Sampietro, Carlo Corbellini, Leonardo Lorusso, Alice Frontali, Isabella Pezzoli, Alessandro Bonomi, Andrea Chierici, Christian Cotsoglou, Giuseppe Manca, Antonella Delvecchio, Nicola Musa, Massimiliano Casati, Laface Letizia, Emmanuele Abate, Giorgio Ercolani, Fabrizio D'Acapito, Leonardo Solaini, Gianluca Guercioni, Simone Cicconi, Diego Sasia, Felice Borghi, Giorgio Giraudo, Giuseppe Sena, Pasquale Castaldo, Eugenia Cardamone, Giuseppe Portale, Matteo Zuin, Ylenia Spolverato, Marialusia Esposito, Roberta Maria Isernia, Maria Di Salvo, Romina Manunza, Giuseppe Esposito, Marcello Agus, Emanuele Luigi Giuseppe Asti, Daniele Tiziano Bernardi, Tommaso Panici Tonucci, Davide Luppi, Massimiliano Casadei, Stefano Bonilauri, Angela Pezzolla, Annunziata Panebianco, Rita Laforgia, Maurizio De Luca, Monica Zese, Dario Parini, Elio Jovine, Giuseppina De Sario, Raffaele Lombardi, Giovanni Aprea, Giuseppe Palomba, Marianna Capuano, Giulio Argenio, Gianluca Orio, Mariano Fortunato Armellino, Marina Troian, Martina Guerra, Carlo Nagliati, Alan Biloslavo, Paola Germani, Giada Aizza, Igor Monsellato, Ali Chaouki Chahrour, Gabriele Anania, Cristina Bombardini, Francesco Bagolini, Gabriele Sganga, Pietro Fransvea, Valentina Bianchi, Paolo Boati, Francesco Ferrara, Francesco Palmieri, Pasquale Cianci, Domenico Gattulli, Enrico Restini, Nicola Cillara, Alessandro Cannavera, Gabriela Elisa Nita, Jlenia Sarnari, Francesco Roscio, Federico Clerici, Ildo Scandroglio, Stefano Berti, Alessandro Cadeo, Alice Filippelli, Luigi Conti, Carmine Grassi, Gaetano Maria Cattaneo, Marina Pighin, Davide Papis, Giovanni Gambino, Vanessa Bertino, Domenico Schifano, Daniela Prando, Luisella Fogato, Fabio Cavallo, Luca Ansaloni, Roberto Picheo, Nicholas Pontarolo, Norma Depalma, Marcello Spampinato, Stefano D'Ugo, Luca Lepre, Michela Giulii Capponi, Rossella Domenica Campa, Giuliano Sarro, Vincenza Paola Dinuzzi, Stefano Olmi, Matteo Uccelli, Davide Ferrari, Marco Inama, Gianluigi Moretto, Michele Fontana, Francesco Favi, Erika Picariello, Alessia Rampini, Andrea Barberis, Antonio Azzinnaro, Alba Oliva, Luigi Totaro, Ilaria Benzoni, Valerio Ranieri, Gabriella Teresa Capolupo, Filippo Carannante, Marco Caricato, Maurizio Ronconi, Silvia Casiraghi, Giovanni Casole, Desire Pantalone, Giovanni Alemanno, Maximilian Scheiterle, Marco Ceresoli, Marco Cereda, Chiara Fumagalli, Federico Zanzi, Stefano Bolzon, Enrico Guerra, Francesca Lecchi, Paola Cellerino, Antonella Ardito, Rosa Scaramuzzo, Andrea Balla, Pasquale Lepiane, Nicola Tartaglia, Antonio Ambrosi, Giovanna Pavone, Gian Marco Palini, Simone Veneroni, Gianluca Garulli, Claudio Ricci, Beatrice Torre, Iris Shari Russo, Matteo Rottoli, Marta Tanzanu, Angela Belvedere, Marco Milone, Michele Manigrasso, Giovanni Domenico De Palma, Micaela Piccoli, Gianmaria Casoni Pattacini, Stefano Magnone, Paolo Bertoli, Michele Pisano, Paolo Massucco, Marco Palisi, Andrea-Pierre Luzzi, Francesco Fleres, Guglielmo Clarizia, Alessandro Spolini, Yoshiro Kobe, Takayuki Toma, Fumihiko Shimamura, Robert Parker, Sinkeet Ranketi, Mercy Mitei, Saulius Svagzdys, Henrikas Pauzas, Justas Zilinskas, Tomas Poskus, Marius Kryzauskas, Matas Jakubauskas, Andee Dzulkarnaen Zakaria, Zaidi Zakaria, Michael Pak-Kai Wong, Asri Che Jusoh, Muhammad Nazreen Zakaria, Daniel Rios Cruz, Aurea Barbara Rodriguez Elizalde, Alejandro Bañon Reynaud, Edgard Efren Lozada Hernandez, Jose Maria Victor Palomo Monroy, Diego Hinojosa-Ugarte, Martha Quiodettis, María Esther Du Bois, José Latorraca, Piotr Major, Michał Pędziwiatr, Magdalena Pisarska-Adamczyk, Maciej Walędziak, Andrzej Kwiatkowski, Łukasz Czyżykowski, Silvia Dantas da Costa, Bela Pereira, Ana Rita Oliveira Ferreira, Filipe Almeida, Ricardo Rocha, Carla Carneiro, Diego Pita Perez, João Carvas, Catarina Rocha, Cátia Ferreira, Rita Marques, Urânia Fernandes, Pedro Leao, André Goulart, Rita Gonçalves Pereira, Sara Daniela Direito Patrocínio, Nuno Gonçalo Gonçalves de Mendonça, Maria Isabel Cerqueira Manso, Henrique Manuel Cardoso Morais, Paulo Sebastião Cardoso, Valentin Calu, Adrian Miron, Elena Adelina Toma, Mahir Gachabayov, Abakar Abdullaev, Andrey Litvin, Taras Nechay, Alexander Tyagunov, Anvar Yuldashev, Alison Bradley, Michael Wilson, Arpád Panyko, Zuzana Látečková, Vladimír Lacko, Dusan Lesko, Marek Soltes, Jozef Radonak, Victor Turrado-Rodriguez, Roser Termes-Serra, Xavier Morales-Sevillano, Pierfrancesco Lapolla, Andrea Mingoli, Gioia Brachini, Maurizio Degiuli, Silvia Sofia, Rossella Reddavid, Andrea de Manzoni Garberini, Angelica Buffone, Eduardo Perea Del Pozo, Daniel Aparicio-Sánchez, Sandra Dos Barbeito, Mercedes Estaire-Gómez, Rebeca Vitón-Herrero, Mª de Los Ángeles Gil Olarte-Marquez, José Gil-Martínez, Felipe Alconchel, Tatiana Nicolás-López, Aida Cristina Rahy-Martin, María Pelloni, Raquel Bañolas-Suarez, Fernando Mendoza-Moreno, Francisca García-Moreno Nisa, Manuel Díez-Alonso, María Elisa Valle Rodas, María Carmona Agundez, María Inmaculada Pérez Andrés, Claudia Cristina Lopes Moreira, Aintzane Lizarazu Perez, Iñigo Augusto Ponce, Ana María González-Castillo, Estela Membrilla-Fernández, Silvia Salvans, Mario Serradilla-Martín, Pablo Sancho Pardo, Daniel Rivera-Alonso, Jana Dziakova, Jose Mugüerza Huguet, Naila Pagès Valle, Enrique Colás Ruiz, Cristina Rey Valcárcel, Cristina Ruiz Moreno, Yeniffer Tatiana Moreno Salazar, Juan Jesús Rubio García, Silvia Sevila Micó, Joaquín Ruiz López, Silvia Pérez Farré, Maite Santamaria Gomez, Nuria Mestres Petit, Alberto Titos-García, Jose Manuel Aranda-Narváez, Laura Romacho-López, Luis Sánchez-Guillén, Veronica Aranaz-Ostariz, Marina Bosch-Ramírez, Aleix Martínez-Pérez, Elías Martínez-López, Juan Carlos Sebastián-Tomás, Granada Jimenez-Riera, Javier Jimenez-Vega, Jose Aurelio Navas Cuellar, Andrea Campos-Serra, Anna Muñoz-Campaña, Raquel Gràcia-Roman, Javier Martínez Alegre, Francisca Lima Pinto, Sara Nuñez O'Sullivan, Francisco Blanco Antona, Beatriz Muñoz Jiménez, Jaime López-Sánchez, Zahira Gómez Carmona, Rocio Torres Fernández, Isabel Blesa Sierra, Laura Román García de León, Verónica Polaino Moreno, Eva Iglesias, Paola Lora Cumplido, Altea Arango Bravo, Ignacio Rey Simó, Carlota López Domínguez, Aloia Guerreiro Caamaño, Rafael Calleja Lozano, Manuel Durán Martínez, Álvaro Naranjo Torres, Javier Tomas Morales Bernaldo de Quiros, Gianluca Pellino, Miriam Moratal Cloquell, Elsa García Moller, Sami Jalal-Eldin, Ahmed K Abdoun, Hytham K S Hamid, Varut Lohsiriwat, Aitsariya Mongkhonsupphawan, Oussama Baraket, Karim Ayed, Imed Abbassi, Ali Ben Ali, Houssem Ammar, Ali Kchaou, Ahmed Tlili, Imen Zribi, Elif Colak, Suleyman Polat, Zehra Alan Koylu, Ali Guner, Mehmet Arif Usta, Murat Emre Reis, Baris Mantoglu, Emre Gonullu, Emrah Akin, Fatih Altintoprak, Zulfu Bayhan, Necattin Firat, Arda Isik, Ufuk Memis, Mehmet Bayrak, Yasemin Altıntaş, Yasin Kara, Mehmet Abdussamet Bozkurt, Ali Kocataş, Koray Das, Ahmet Seker, Nazmi Ozer, Semra Demirli Atici, Korhan Tuncer, Tayfun Kaya, Zeynep Ozkan, Onur Ilhan, Ibrahim Agackiran, Mustafa Yener Uzunoglu, Eren Demirbas, Yuksel Altinel, Serhat Meric, Nadir Adnan Hacım, Derya Salim Uymaz, Nail Omarov, Emre Balık, Giovanni D Tebala, Hany Khalil, Mridul Rana, Mansoor Khan, Charlotte Florence, Christie Swaminathan, Cosimo Alex Leo, Lampros Liasis, Josef Watfah, Ivan Trostchansky, Edward Delgado, Marcelo Pontillo, Rifat Latifi, Raul Coimbra, Sara Edwards, Ana Lopez, George Velmahos, Ander Dorken, Anthony Gebran, Amanda Palmer, Jeffrey Oury, James M Bardes, Sirivan Suon Seng, Lauren S Coffua, Asanthi Ratnasekera, Tanya Egodage, Karla Echeverria-Rosario, Isabella Armento, Lena M Napolitano, Naveen F Sangji, Mark Hemmila, Jacob A Quick, Tyler R Austin, Theodore S Hyman, William Curtiss, Amanda McClure, Nicholas Cairl, Walter L Biffl, Hung P Truong, Kathryn Schaffer, Summer Reames, Filippo Banchini, Patrizio Capelli, Federico Coccolini, Massimo Sartelli, Francesca Bravi, Carlo Vallicelli, Vanni Agnoletti, Gian Luca Baiocchi, Fausto Catena
BACKGROUND: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. METHODS: This is a prospective, international, multicenter, observational study registered on ClinicalTrials...
April 16, 2024: World Journal of Emergency Surgery: WJES
https://read.qxmd.com/read/38622987/the-prevalence-and-clinical-significance-of-her2-expression-in-prostate-adenocarcinoma
#9
JOURNAL ARTICLE
Fayez Estephan, Coen J Lap, Jeff Banagan, Martha Antonio, Shanshan Liu, Guoqing Diao, Alexandra Zara Rozalen, Rithika Rajendran, Steven Krasnow, Ramesh Subrahmanyam, Victor E Nava, Maneesh Jain
AIMS: Abnormalities in HER2 are well-established oncogenic drivers and are approved therapeutic targets in various malignancies. Prior studies evaluating HER2 expression in prostate cancer (PCa) have yielded variable results. Most of these studies used immunohistochemistry scoring systems based on breast cancer data. The goal of this study was to determine the prevalence and clinical significance of HER2 expression using a scoring system that better reflects the HER2 staining pattern observed in PCa...
December 2023: Annals of Diagnostic Pathology
https://read.qxmd.com/read/38622597/observed-rates-of-surgical-instrument-errors-point-to-visualization-tasks-as-being-a-critically-vulnerable-point-in-sterile-processing-and-a-significant-cause-of-lost-chargeable-or-minutes
#10
JOURNAL ARTICLE
Peter F Nichol, Mark J Saari, Natalia Navas, David Aguilar, Rita K Bliesner, Paige J Brunner, Jacob C Caceres, Madelyn Chen, Ava R VanDommelen, Matthew Fischer, Simar Garcha, Elaf A Ghawas, Grace R Hackinson, Ava Hitzeman, Maria Jabbour, Amanda M Jentsch, Madison M Kurth, Mollyn Leyden, Qianyun Luo, Abigail C McGrain, Gwendolyn Nytes, Olivia R O'Brien, Jesibell K Philavong, Natalie Villegas, Shannon R Walsh, Sydney S Wisdorf
BACKGROUND: The reporting of surgical instrument errors historically relies on cumbersome, non-automated, human-dependent, data entry into a computer database that is not integrated into the electronic medical record. The limitations of these reporting systems make it difficult to accurately estimate the negative impact of surgical instrument errors on operating room efficiencies. We set out to determine the impact of surgical instrument errors on a two-hospital healthcare campus using independent observers trained in the identification of Surgical Instrument Errors...
April 15, 2024: BMC Surgery
https://read.qxmd.com/read/38621575/baseline-characteristics-including-blood-and-urine-metal-levels-in-the-trial-to-assess-chelation-therapy-2-tact2
#11
JOURNAL ARTICLE
Ana Navas-Acien, Regina M Santella, Bonnie R Joubert, Zhen Huang, Yuliya Lokhnygina, Francisco Ujueta, Irina Gurvich, Nancy J LoIacono, Filippo Ravalli, Cynthia D Ward, Jeffery M Jarrett, Alfonsina De Leon Salazar, Robin Boineau, Teresa L Z Jones, Daniel B Mark, Jonathan D Newman, David M Nathan, Kevin J Anstrom, Gervasio A Lamas
BACKGROUND: The reduction in cardiovascular disease (CVD) events with edetate disodium (EDTA) in the Trial to Assess Chelation Therapy (TACT) suggested that chelation of toxic metals might provide novel opportunities to reduce CVD in patients with diabetes. Lead and cadmium are vasculotoxic metals chelated by EDTA. We present baseline characteristics for participants in TACT2, a randomized, double-masked, placebo-controlled trial designed as a replication of the TACT trial limited to patients with diabetes...
April 13, 2024: American Heart Journal
https://read.qxmd.com/read/38621324/impact-of-cftr-modulator-therapy-on-body-composition-as-assessed-by-thoracic-computed-tomography-a-follow-up-study
#12
JOURNAL ARTICLE
Víctor Navas-Moreno, Fernando Sebastian-Valles, Víctor Rodríguez-Laval, Carolina Knott-Torcal, Mónica Marazuela, Nuria Sánchez de la Blanca, Jose Alfonso Arranz Martín, Rosa María Girón, Miguel Antonio Sampedro-Núñez
OBJECTIVE: Treatment with cystic fibrosis transmembrane conductance regulator (CFTR) modulators in individuals with cystic fibrosis (CF) has brought a significant change in forced expiratory volume in 1 second (FEV1 ) and clinical parameters. However, it also results in weight gain. The aim of our study is to evaluate the effect of CFTR modulator treatment on body composition, measured by computed tomography (CT). METHODS: Adult subjects with CF under follow-up at La Princesa University Hospital were recruited...
March 15, 2024: Nutrition
https://read.qxmd.com/read/38617301/emergent-effects-of-synaptic-connectivity-on-the-dynamics-of-global-and-local-slow-waves-in-a-large-scale-thalamocortical-network-model-of-the-human-brain
#13
Brianna M Marsh, M Gabriela Navas-Zuloaga, Burke Q Rosen, Yury Sokolov, Jean Erik Delanois, Oscar C González, Giri P Krishnan, Eric Halgren, Maxim Bazhenov
Slow-wave sleep (SWS), characterized by slow oscillations (SO, <1Hz) of alternating active and silent states in the thalamocortical network, is a primary brain state during Non-Rapid Eye Movement (NREM) sleep. In the last two decades, the traditional view of SWS as a global and uniform whole-brain state has been challenged by a growing body of evidence indicating that sleep oscillations can be local and can coexist with wake-like activity. However, the understanding of how global and local SO emerges from micro-scale neuron dynamics and network connectivity remains unclear...
April 1, 2024: bioRxiv
https://read.qxmd.com/read/38617190/overexpression-of-mmachc-prevents-craniofacial-phenotypes-caused-by-knockdown-of-znf143b
#14
JOURNAL ARTICLE
Isaiah Perez, Nayeli G Reyes-Nava, Briana E Pinales, Anita M Quintana
ZNF143 is a sequence-specific DNA binding protein that regulates the expression of protein-coding genes and small RNA molecules. In humans, ZNF143 interacts with HCFC1, a transcriptional cofactor, to regulate the expression of downstream target genes, including MMACHC , which encodes an enzyme involved in cobalamin ( cbl ) metabolism. Mutations in HCFC1 or ZNF143 cause an inborn error of cobalamin metabolism characterized by abnormal cbl metabolism, intellectual disability, seizures, and mild to moderate craniofacial abnormalities...
June 2023: American Journal of Undergraduate Research
https://read.qxmd.com/read/38615755/baseline-and-stress-induced-steroid-plasma-levels-and-immune-function-vary-annually-and-are-associated-with-vocal-activity-in-male-toads-rhinella-icterica
#15
JOURNAL ARTICLE
Braz Titon Junior, Adriana Maria Giorgi Barsotti, Stefanny Christie Monteiro Titon, Renata Ibelli Vaz, Aymam Cobo de Figueiredo, Ronyelle Vasconcelos-Teixeira, Carlos A Navas, Fernando Ribeiro Gomes
Theoretical models predict that elevated androgen and glucocorticoid levels in males during the reproductive season promote immunosuppression. However, some studies report decreased stress response during this season. This study investigated annual variation in plasma corticosterone and testosterone levels, plasma bacterial killing ability (BKA), and neutrophil to lymphocyte ratio (NLR) in free-living male toads (Rhinella icterica). Toads were sampled in the field (baseline) and 1 h-post restraint over five months, and we considered the occurrence of vocal activity...
April 12, 2024: General and Comparative Endocrinology
https://read.qxmd.com/read/38615397/removal-of-pahs-tss-oils-and-fats-from-ammonium-rich-coke-wastewater-by-granular-filtration
#16
JOURNAL ARTICLE
Rodríguez-Iglesias Jesús, Megido Laura, Fernández-Nava Yolanda, Suárez-Peña Beatriz
Coke wastewater is a complex industrial wastewater due to its high content of toxic compounds such as cyanides, thiocyanates, phenols, tar, oils, and fats. After a series of treatments, wastewater with a high ammonium content is obtained (around 4,150 mg·L-1). A stripping process is used to reduce it. Certain pollutants in the influent, such as tar, polycyclic aromatic hydrocarbons (PAHs), oils, fats and total suspended solids (TSS), interfere with stripping and therefore must be previously removed. In this study, the performance of a pilot-scale airlift sand filter was evaluated under real conditions for the reduction of the concentration of tar, PAHs, oils, fats and TSS, before stripping...
April 13, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38613891/verified-localization-and-pharmacognosy-of-herbal-medicinal-plants-in-a-combined-network-framework
#17
JOURNAL ARTICLE
Misaj Sharafudeen, Vinod Chandra S S, Aswathy A L, Asif Navas, Vismaya K N
Pharmacognosy from medicinal plants involves the scientific domain of medicinal compounding based on their medicinal properties. Accurate identification of medicinal plants is crucial, especially by examining their leaves. Choosing the wrong plant species for medicinal preparations can have adverse side effects. This study presents a Human-Centered Artificial Intelligence approach for medicinal plant identification, combining a YOLOv7-based Leaf Localizer with a leaf Class Verifier based on DenseNet through a Confidence Score Analyser algorithm...
April 12, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38612370/analysis-of-endangered-andalusian-black-cattle-negra-andaluza-reveals-genetic-reservoir-for-bovine-black-trunk
#18
JOURNAL ARTICLE
Luis Favian Cartuche Macas, María Esperanza Camacho Vallejo, Antonio González Ariza, José Manuel León Jurado, Juan Vicente Delgado Bermejo, Carmen Marín Navas, Francisco Javier Navas González
This comprehensive study on the Andalusian Black cattle breed reveals a substantial population decline, with the average herd size decreasing significantly from 305.54 to 88.28 animals per herd. This decline is primarily attributed to agricultural changes and the introduction of foreign meat-focused breeds. The male-to-female ratio shift is noteworthy, with more cows than bulls, impacting selection intensity for both genders. Inbreeding levels, though relatively low historically (5.94%) and currently (7.23%), raise concerns as 37...
April 8, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38610754/biomarkers-in-systemic-lupus-erythematosus-along-with-metabolic-syndrome
#19
REVIEW
Fernanda Isadora Corona-Meraz, Mónica Vázquez-Del Mercado, Flavio Sandoval-García, Jesus-Aureliano Robles-De Anda, Alvaro-Jovanny Tovar-Cuevas, Roberto-Carlos Rosales-Gómez, Milton-Omar Guzmán-Ornelas, Daniel González-Inostroz, Miguel Peña-Nava, Beatriz-Teresita Martín-Márquez
Metabolic syndrome (MetS) is a group of physiological abnormalities characterized by obesity, insulin resistance (IR), and hypertriglyceridemia, which carry the risk of developing cardiovascular disease (CVD) and type 2 diabetes (T2D). Immune and metabolic alterations have been observed in MetS and are associated with autoimmune development. Systemic lupus erythematosus (SLE) is an autoimmune disease caused by a complex interaction of environmental, hormonal, and genetic factors and hyperactivation of immune cells...
March 29, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38610627/risk-factors-associated-with-adverse-events-leading-to-methotrexate-withdrawal-in-elderly-rheumatoid-arthritis-patients-a-retrospective-cohort-study
#20
JOURNAL ARTICLE
Felipe Alexis Avalos-Salgado, Laura Gonzalez-Lopez, Sergio Gonzalez-Vazquez, Juan Manuel Ponce-Guarneros, Aline Priscilla Santiago-Garcia, Edna Lizeth Amaya-Cabrera, Reynaldo Arellano-Cervantes, J Ahuixotl Gutiérrez-Aceves, Miriam Fabiola Alcaraz-Lopez, Cesar Arturo Nava-Valdivia, Fabiola Gonzalez-Ponce, Norma Alejandra Rodriguez-Jimenez, Miguel Angel Macias-Islas, Edgar Ricardo Valdivia-Tangarife, Ana Miriam Saldaña-Cruz, Ernesto German Cardona-Muñoz, Jorge Ivan Gamez-Nava
Background: Rheumatoid arthritis (RA) in elderly population represents a challenge for physicians in terms of therapeutic management. Methotrexate (MTX) is the first-line treatment among conventional synthetic-disease-modifying anti-rheumatic drugs (cs-DMARDs); however, it is often associated with adverse events (AEs). Therefore, the objective of this study was to identify the incidence and risk factors of MTX discontinuation due to AEs in elderly patients with RA in a long-term retrospective cohort study. Methods: Clinical sheets from elderly RA patients taking MTX from an outpatient rheumatology consult in a university centre were reviewed...
March 24, 2024: Journal of Clinical Medicine
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