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https://www.readbyqxmd.com/read/29679597/management-of-dyspnea-in-the-terminally-ill
#1
REVIEW
Lara Pisani, Nicholas S Hill, Angela Maria Grazia Pacilli, Massimiliano Polastri, Stefano Nava
The genesis of dyspnea involves the activation of several mechanisms that are mediated and perceived depending on previous experiences, values, emotions and beliefs. Breathlessness may become unbearable, especially in terminally ill patients, whether afflicted by respiratory, cardiac or cancer-related disorders, due to a final stage of a chronic process, an acute event or both. Compared to pain, palliation of dyspnea has received relatively little attention in clinical practice and the medical literature. This is particularly true when the breathlessness is associated with acute respiratory failure since most of the studies on pharmacological and non-pharmacological treatments of respiratory distress have excluded such patients...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29676648/global-tobacco-use-old-and-new-products
#2
Ana Navas-Acien
Tobacco use and exposure to tobacco smoke remain major but avoidable causes of premature mortality and disease worldwide. Although the age-standardized prevalence of daily smoking has declined for both men and women in many countries, the number of smokers continues to increase because of global population growth. Although cigarettes are the most commonly used tobacco product, the tobacco epidemic has become tremendously complex with the emergence and popularity of alternative products such as waterpipes and electronic cigarettes (also known as e-cigarettes)...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676622/low-to-moderate-arsenic-exposure-and-respiratory-health-in-american-indian-communities
#3
Martha Powers, Tiffany R Sanchez, Maria Grau-Perez, Fawn Yeh, Kevin Francesconi, Walter Goessler, Christine M George, Christopher Heaney, Lyle G Best, Jason Umans, Robert H Brown, Ana Navas-Acien
RATIONALE: Exposure to inorganic arsenic, through drinking naturally-contaminated water, is an established cause of lung cancer. Evidence on the impact of arsenic exposure on lung function, however, is less conclusive. The evidence available, mostly from populations exposed to water arsenic levels >100 μg/L, suggests that arsenic exposure is associated with lower lung function. Prospective studies and studies examining low-to-moderate levels of water arsenic exposure (<50 μg/L) the level relevant for U...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29670917/pancreatic-beta-cell-death-novel-potential-mechanisms-in-diabetes-therapy
#4
REVIEW
Joselyn Rojas, Valmore Bermudez, Jim Palmar, María Sofía Martínez, Luis Carlos Olivar, Manuel Nava, Daniel Tomey, Milagros Rojas, Juan Salazar, Carlos Garicano, Manuel Velasco
Purpose of Review: Describing the diverse molecular mechanisms (particularly immunological) involved in the death of the pancreatic beta cell in type 1 and type 2 diabetes mellitus. Recent Findings: Beta cell death is the final event in a series of mechanisms that, up to date, have not been entirely clarified; it represents the pathophysiological mechanism in the natural history of diabetes mellitus. These mechanisms are not limited to an apoptotic process only, which is characteristic of the immune-mediated insulitis in type 1 diabetes mellitus...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29666450/novel-hla-class-i-associations-with-hiv-1-control-in-a-unique-genetically-admixed-population
#5
Humberto Valenzuela-Ponce, Selma Alva-Hernández, Daniela Garrido-Rodríguez, Maribel Soto-Nava, Thalía García-Téllez, Tania Escamilla-Gómez, Claudia García-Morales, Verónica Sonia Quiroz-Morales, Daniela Tapia-Trejo, Silvia Del Arenal-Sánchez, Francisco-Javier Prado-Galbarro, Ramón Hernández-Juan, Edna Rodríguez-Aguirre, Akio Murakami-Ogasawara, Carlos Mejía-Villatoro, Ingrid Y Escobar-Urias, Rodolfo Pinzón-Meza, Juan Miguel Pascale, Yamitzel Zaldivar, Guillermo Porras-Cortés, Carlos Quant-Durán, Ivette Lorenzana, Rita I Meza, Elsa Y Palou, Marvin Manzanero, Rolando A Cedillos, Carmen Aláez, Mark A Brockman, P Richard Harrigan, Chanson J Brumme, Zabrina L Brumme, Santiago Ávila-Ríos, Gustavo Reyes-Terán
Associations between HLA class I alleles and HIV progression in populations exhibiting Amerindian and Caucasian genetic admixture remain understudied. Using univariable and multivariable analyses we evaluated HLA associations with five HIV clinical parameters in 3,213 HIV clade B-infected, ART-naïve individuals from Mexico and Central America (MEX/CAM cohort). A Canadian cohort (HOMER, n = 1622) was used for comparison. As expected, HLA allele frequencies in MEX/CAM and HOMER differed markedly. In MEX/CAM, 13 HLA-A, 24 HLA-B, and 14 HLA-C alleles were significantly associated with at least one clinical parameter...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29660445/development-of-a-new-tool-for-the-long-term-in-vitro-ecotoxicity-testing-of-nanomaterials-using-a-rainbow-trout-cell-line-rtl-w1
#6
L Galbis-Martínez, M L Fernández-Cruz, L Alte, A Valdehita, I Rucandio, J M Navas
The current wide use of manufactured nanomaterials (MNs) is leading to the release of nanoparticles (NPs) to water bodies. Aquatic organisms, including fish, are exposed to low concentrations of NPs for long periods of time being necessary to develop laboratory toxicity tests reflecting realistic conditions. Additionally, today there is a demand of in vitro assays respecting the 3Rs principle. Thus, the main aim of this work was to stablish an in vitro tool for the assessment of long-term NPs ecotoxicity. Considering the key role of liver in detoxification, a rainbow trout liver cell line, RTL-W1, was used...
April 13, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29656894/deterministic-evolutionary-trajectories-influence-primary-tumor-growth-tracerx-renal
#7
Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Stuart Horswell, Tim Chambers, Tim O'Brien, Jose I Lopez, Thomas B K Watkins, David Nicol, Mark Stares, Ben Challacombe, Steve Hazell, Ashish Chandra, Thomas J Mitchell, Lewis Au, Claudia Eichler-Jonsson, Faiz Jabbar, Aspasia Soultati, Simon Chowdhury, Sarah Rudman, Joanna Lynch, Archana Fernando, Gordon Stamp, Emma Nye, Aengus Stewart, Wei Xing, Jonathan C Smith, Mickael Escudero, Adam Huffman, Nik Matthews, Greg Elgar, Ben Phillimore, Marta Costa, Sharmin Begum, Sophia Ward, Max Salm, Stefan Boeing, Rosalie Fisher, Lavinia Spain, Carolina Navas, Eva Grönroos, Sebastijan Hobor, Sarkhara Sharma, Ismaeel Aurangzeb, Sharanpreet Lall, Alexander Polson, Mary Varia, Catherine Horsfield, Nicos Fotiadis, Lisa Pickering, Roland F Schwarz, Bruno Silva, Javier Herrero, Nick M Luscombe, Mariam Jamal-Hanjani, Rachel Rosenthal, Nicolai J Birkbak, Gareth A Wilson, Orsolya Pipek, Dezso Ribli, Marcin Krzystanek, Istvan Csabai, Zoltan Szallasi, Martin Gore, Nicholas McGranahan, Peter Van Loo, Peter Campbell, James Larkin, Charles Swanton
The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, TRACERx Renal. We observe up to 30 driver events per tumor and show that subclonal diversification is associated with known prognostic parameters. By resolving the patterns of driver event ordering, co-occurrence, and mutual exclusivity at clone level, we show the deterministic nature of clonal evolution...
April 11, 2018: Cell
https://www.readbyqxmd.com/read/29656858/a-recurrent-de-novo-pacs2-heterozygous-missense-variant-causes-neonatal-onset-developmental-epileptic-encephalopathy-facial-dysmorphism-and-cerebellar-dysgenesis
#8
Heather E Olson, Nolwenn Jean-Marçais, Edward Yang, Delphine Heron, Katrina Tatton-Brown, Paul A van der Zwaag, Emilia K Bijlsma, Bryan L Krock, E Backer, Erik-Jan Kamsteeg, Margje Sinnema, Margot R F Reijnders, David Bearden, Amber Begtrup, Aida Telegrafi, Roelineke J Lunsing, Lydie Burglen, Gaetan Lesca, Megan T Cho, Lacey A Smith, Beth R Sheidley, Christelle Moufawad El Achkar, Phillip L Pearl, Annapurna Poduri, Cara M Skraban, Jennifer Tarpinian, Addie I Nesbitt, Dietje E Fransen van de Putte, Claudia A L Ruivenkamp, Patrick Rump, Nicolas Chatron, Isabelle Sabatier, Julitta De Bellescize, Laurent Guibaud, David A Sweetser, Jessica L Waxler, Klaas J Wierenga, Jean Donadieu, Vinodh Narayanan, Keri M Ramsey, Caroline Nava, Jean-Baptiste Rivière, Antonio Vitobello, Frédéric Tran Mau-Them, Christophe Philippe, Ange-Line Bruel, Yannis Duffourd, Laurel Thomas, Stefan H Lelieveld, Janneke Schuurs-Hoeijmakers, Han G Brunner, Boris Keren, Julien Thevenon, Laurence Faivre, Gary Thomas, Christel Thauvin-Robinet
Developmental and epileptic encephalopathies (DEEs) represent a large clinical and genetic heterogeneous group of neurodevelopmental diseases. The identification of pathogenic genetic variants in DEEs remains crucial for deciphering this complex group and for accurately caring for affected individuals (clinical diagnosis, genetic counseling, impacting medical, precision therapy, clinical trials, etc.). Whole-exome sequencing and intensive data sharing identified a recurrent de novo PACS2 heterozygous missense variant in 14 unrelated individuals...
April 10, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29655462/obesity-thrombotic-risk-and-inflammation-in-cancer
#9
Benjamín Rubio-Jurado, Luz-Ma-Adriana Balderas-Peña, Eduardo E García-Luna, María G Zavala-Cerna, Carlos Riebeling-Navarro, Pedro A Reyes, Arnulfo H Nava-Zavala
Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29650041/deep-learning-meets-ontologies-experiments-to-anchor-the-cardiovascular-disease-ontology-in-the-biomedical-literature
#10
Mercedes Arguello Casteleiro, George Demetriou, Warren Read, Maria Jesus Fernandez Prieto, Nava Maroto, Diego Maseda Fernandez, Goran Nenadic, Julie Klein, John Keane, Robert Stevens
BACKGROUND: Automatic identification of term variants or acceptable alternative free-text terms for gene and protein names from the millions of biomedical publications is a challenging task. Ontologies, such as the Cardiovascular Disease Ontology (CVDO), capture domain knowledge in a computational form and can provide context for gene/protein names as written in the literature. This study investigates: 1) if word embeddings from Deep Learning algorithms can provide a list of term variants for a given gene/protein of interest; and 2) if biological knowledge from the CVDO can improve such a list without modifying the word embeddings created...
April 12, 2018: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29642862/effectiveness-and-safety-of-moderate-intensity-aerobic-water-exercise-during-pregnancy-for-reducing-use-of-epidural-analgesia-during-labor-protocol-for-a-randomized-clinical-trial
#11
Araceli Navas, Catalina Artigues, Alfonso Leiva, Elena Portells, Aina Soler, Antonia Cladera, Silvia Ortas, Margarita Alomar, Marina Gual, Concepción Manzanares, Marina Brunet, Magdalena Julià, Lidia López, Lorena Granda, Miquel Bennasar-Veny, Mari Carmen Carrascosa
BACKGROUND: Epidural analgesia during labor can provide effective pain relief, but can also lead to adverse effects. The practice of moderate exercise during pregnancy is associated with an increased level of endorphins in the blood, and this could also provide pain relief during labor. Aerobic water exercises, rather than other forms of exercise, do not negatively impact articulations, reduce edema, blood pressure, and back pain, and increase diuresis. We propose a randomized controlled trial (RCT) to evaluate the effectiveness and safety of a moderate water exercise program during pregnancy on the need for epidural analgesia during labor...
April 11, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29624211/influence-of-maternal-negative-emotion-reactivity-and-cognitive-reappraisal-on-child-anxiety-disorder
#12
Nava Wald, Tal Carthy, Vered Shenaar-Golan, Yael Tadmor-Zisman, Maayan Ziskind
BACKGROUND: Anxiety disorders are among the most common psychopathologies in childhood. Two underlying contributors to child anxiety disorders (ADs) are negative emotional hyper-reactivity and deficits in reappraisal, a cognitive strategy of emotion regulation. Given that emotion regulation develops in the context of parent-child interaction, the aim of this study was to fill a research gap regarding the association between maternal negative emotional reactivity (NER) and reappraisal and child anxiety by examining (a) whether mothers of children with ADs display abnormalities in emotional reactivity and reappraisal compared to mothers of children without ADs; (b) whether maternal NER and reappraisal are associated with child anxiety; and (c) whether maternal reactivity and reappraisal significantly explain the variance in the level of child anxiety beyond the level of maternal anxiety...
April 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29623518/influence-of-a-preventive-program-on-the-oral-health-related-quality-of-life-ohrqol-of-european-pregnant-women-a-cohort-study
#13
Yolanda Martínez-Beneyto, Javier Montero-Martin, Francisco Garcia-Navas, Ascension Vicente-Hernandez, Antonio Jose Ortiz-Ruiz, Fabio Camacho-Alonso
The aim of this study was to compare the impact of oral health on quality of life of a group of pregnant women enrolled in a program of oral health with respect to a control group of non-pregnant women. A cross-sectional study involving a sociodental indicator OHIP-14 and a dental examination was completed to assess pregnant women's knowledge of oral health, hygienic habits, periodontal and caries index. Data were collected from 113 pregnant women and 113 non-pregnant women. Sociodemographic data for both groups were homogeneous...
April 6, 2018: Odontology
https://www.readbyqxmd.com/read/29621497/arsenic-gene-interactions-and-beta-cell-function-in-the-strong-heart-family-study
#14
Poojitha Balakrishnan, Ana Navas-Acien, Karin Haack, Dhananjay Vaidya, Jason G Umans, Lyle G Best, Walter Goessler, Kevin A Francesconi, Nora Franceschini, Kari E North, Shelley A Cole, V Saroja Voruganti, Matthew O Gribble
We explored arsenic-gene interactions influencing pancreatic beta-cell activity in the Strong Heart Family Study (SHFS). We considered 42 variants selected for associations with either beta-cell function (31 variants) or arsenic metabolism (11 variants) in the SHFS. Beta-cell function was calculated as homeostatic model - beta corrected for insulin resistance (cHOMA-B) by regressing homeostatic model - insulin resistance (HOMA-IR) on HOMA-B and adding mean HOMA-B. Arsenic exposure was dichotomized at the median of the sum of creatinine-corrected inorganic and organic arsenic species measured by high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICPMS)...
April 2, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29618014/glutathione-the-major-redox-regulator-in-the-prefrontal-cortex-of-individuals-at-clinical-high-risk-for-psychosis
#15
Tania Da Silva, Sina Hafizi, Ana C Andreazza, Michael Kiang, R Michael Bagby, Efren Navas, Isabelle Laksono, Peter Truong, Cory Gerritsen, Ivana Prce, Napapon Sailasuta, Romina Mizrahi
Introduction: Oxidative stress and glutathione dysregulation have been implicated in the etiology of schizophrenia. To date, most in vivo studies have investigated alterations in cerebral glutathione levels in patients in which the disorder is already established; however, whether oxidative stress actually predates the onset of psychosis remains unknown. In the current study, we investigated cerebral glutathione levels of antipsychotic-naïve individuals at clinical high risk for psychosis...
April 1, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29616858/role-of-yin-yang-1-yy1-in-the-transcription-regulation-of-the-multi-drug-resistance-mdr1-gene
#16
Gabriela Antonio-Andrés, Jesus Rangel-Santiago, Belen Tirado-Rodríguez, Gustavo U Martinez-Ruiz, Miguel Klunder-Klunder, Mario I Vega, Briceida Lopez-Martinez, Elva Jiménez-Hernández, Jose Torres Nava, Aurora Medina-Sanson, Sara Huerta-Yepez
Resistance to chemotherapy hinders the successful treatment of acute lymphoblastic leukemia (ALL). The multi-drug resistance-1 (MDR1/ABCB1) gene encodes P-glycoprotein (P-gp), which plays an important role in chemoresistance; however, its transcriptional regulation remains unclear. We investigated the role of YY1 in the regulation of MDR1 and its relation to ALL outcomes. Analysis of the MDR1 promoter revealed four putative YY1-binding sites, which we analyzed using a reporter system and ChIP analysis. YY1 silencing resulted in the inhibition of MDR1 expression and function...
April 4, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29616139/association-of-p53-gene-polymorphism-with-gastric-cancer-in-northern-iran-as-a-high-risk-region
#17
Akbar Hedayatizadeh-Omran, Reza Alizadeh-Navaei, Ghasem Janbabaei, Versa Omrani-Nava, Yahya Hasheminasab, Omolbanin Amjadi, Mohsen Tehrani
Gastric cancer has the fourth highest morbidity rate of all cancers worldwide. Genetic factors including alterations in oncogenes and tumor suppressor genes serve an important role in gastric cancer development and progression. The P53 gene acts as a tumor suppressor gene by regulating the cell cycle, DNA transcription and repair, apoptosis, senescence and genome stability. In addition to somatic P53 mutations in cancer development, germline polymorphisms are also involved in different malignancies. The polymorphism of P53 at codon 72 (Arg72Pro) is established as a common variant that increases susceptibility to various cancers...
May 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29609968/hepatitis-b-infection-control-in-colombian-amazon-after-15-years-of-hepatitis-b-vaccination-effectiveness-of-birth-dose-and-current-prevalence
#18
Diego Garcia, Alexandra Porras, Alejadro Rico Mendoza, Nelson Alvis, Maria Cristina Navas, Fernando De La Hoz, Marlen De Neira, Elkin Osorio, José Fernando Valderrama
BACKGROUND: Hepatitis B virus (HBV) infection is highly endemic in the Colombian Amazon basin. In Colombia, the universal hepatitis B vaccination in that area has been active since 1993. The program targets children aged under five years. Newborns receive at least three doses, and in 2001, HBV vaccine birth dose was included. This study aimed to evaluate the advances on HBV control in the Colombian Amazon. METHODS: A population-based cross-sectional study was conducted in children less than 11 years old in rural areas of the Colombian Amazon, in order to assess the current levels of HBV prevalence and evaluate the effectiveness of HBV vaccination...
March 30, 2018: Vaccine
https://www.readbyqxmd.com/read/29606032/men-of-mexican-origin-who-abuse-women-a-qualitative-study
#19
Nora Montalvo-Liendo, Debra W Matthews, Heidi Gilroy, Angeles Nava, Christyn Gangialla
BACKGROUND: Current literature indicates that intimate partner violence is a complex phenomenon that exists worldwide. PURPOSE: However, little is known about why some men of Mexican origin abuse women. This descriptive study was conducted to understand the experiences of men of Mexican origin who abuse their intimate partners. METHOD: A qualitative research design was used to conduct this study in a south Texas border community adjacent to the United States-Mexico border...
March 1, 2018: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
https://www.readbyqxmd.com/read/29605538/cadmium-body-burden-hypertension-and-changes-in-blood-pressure-over-time-results-from-a-prospective-cohort-study-in-american-indians
#20
Clare Oliver-Williams, Annie Green Howard, Ana Navas-Acien, Barbara V Howard, Maria Tellez-Plaza, Nora Franceschini
American Indian communities are at greater risk of hypertension and cardiovascular disease than the general US population and are exposed to greater cadmium levels. However, cadmium's effect on blood pressure is unclear. This study assesses the association between baseline urinary cadmium and longitudinal changes in blood pressure in American Indian communities. Cadmium was measured in 3047 baseline urine samples from Strong Heart Study participants from three geographic areas. Longitudinal changes in blood pressure across three study visits (1989-1999) were modeled using linear mixed models by baseline log urinary cadmium to creatinine ratio...
March 10, 2018: Journal of the American Society of Hypertension: JASH
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