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https://www.readbyqxmd.com/read/29921576/prolactin-as-immune-cell-regulator-in-toxocara-canis-somatic-larvae-chronic-infection
#1
Victor Hugo Del Rio-Araiza, Karen Elizabeth Nava-Castro, Fernando Alba-Hurtado, Andrés Quintanar-Stephano, Hugo Aguilar-Díaz, Marco Antonio Muñoz-Guzmán, Pedro Ostoa-Saloma, Maria Dolores Ponce-Regalado, Jorge Morales-Montor
Toxocariasis is a zoonotic disease produced by ingestion of larval Toxocara spp. eggs. Prolactin has been considered to have an important role in Toxocara canis infection. Recent evidence has found that prolactin directly can increase parasite growth and differentiation of T. canis The present study, evaluated the effect of high prolactin levels on the immune system's response and parasites clearance in chronic infection. Our results showed that hiperprolactinemia did not affected the number of larvae recovered from several tissues in rats...
June 19, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29914177/effect-of-nicotine-on-cyp2b1-expression-in-a-glioma-animal-model-and-analysis-of-cyp2b6-expression-in-pediatric-gliomas
#2
Sonia Nava-Salazar, Saúl Gómez-Manzo, Jaime Marcial-Quino, Alfonso Marhx-Bracho, Bryan V Phillips-Farfán, Carlos Diaz-Avalos, America Vanoye-Carlo
Cyclophosphamide (CPA) is a pro-drug commonly used in the chemotherapeutic schemes for glioma treatment but has high toxicity and the side effects include brain damage and even death. Since CPA is activated mainly by CY2B6, over-expression of the enzyme in the tumor cells has been proposed to enhance CPA activation. In this study, we explored the induction of the Cyp2b1 (homologous to CYP2B6 ) by nicotine in an animal rat model with glioma. Gene expression and protein levels were analyzed by RT-PCR and Western blot...
June 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29913170/seasonal-changes-in-plasma-concentrations-of-the-thyroid-glucocorticoid-and-reproductive-hormones-in-the-tegu-lizard-salvator-merianae
#3
Lucas A Zena, Danielle Dillon, Kathleen E Hunt, Carlos A Navas, Kênia C Bícego, C Loren Buck
The tegu lizard Salvator merianae is a large, widely distributed teiid lizard endemic to South America that exhibits annual cycles of high activity during the spring and summer, and hibernation during winter. This pattern of activity and hibernation is accompanied by profound seasonal changes in physiology and behavior, including endothermy during the austral spring. The unusual combination of seasonal endothermy, hibernation and oviparity, in a non-avian, non-mammalian species, makes S. merianae an interesting subject for study of comparative aspects of endocrine regulation of seasonal changes in physiology...
June 15, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29912254/-human-pegivirus-pathogenic-potential-and-non-hodgkin-lymphoma-development-risk
#4
Johanna C Arroyave-Ospina, María Fernanda Caicedo, María Cristina Navas, Fabián M Cortés-Mancera
The human pegivirus (HPgV), classified in the Flaviviridae family - Pegivirus genus, is an RNA virus identified in 1995. HPgV is a lymphotrophic virus, with replication sites in bone marrow and lymphoid tissue, as well as in peripheral blood mononuclear cells (PBMCs). Transmission is through sexual and parenteral routes, and recent estimations suggest nearly 750 million people are infected with HPgV worldwide. Almost 25% of infected individuals can develop persistent infection. Until now, HPgV has been considered a non-pathogenic virus; however, epidemiological studies suggest a potential role in lymphoproliferative diseases, particularly in the development of non-Hodgkin lymphoma (NHL)...
April 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29911795/current-knowledge-and-future-perspectives-in-breast-surgery-an-overview
#5
Maurizio B Nava, Giuseppe Catanuto, Nicola Rocco
No abstract text is available yet for this article.
June 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29911685/docetaxel-treatment-in-pten-and-erg-aberrant-metastatic-prostate-cancers
#6
Pasquale Rescigno, David Lorente, David Dolling, Roberta Ferraldeschi, Daniel Nava Rodrigues, Ruth Riisnaes, Susana Miranda, Diletta Bianchini, Zafeiris Zafeiriou, Spyridon Sideris, Ana Ferreira, Ines Figueiredo, Semini Sumanasuriya, Joaquin Mateo, Raquel Perez-Lopez, Adam Sharp, Nina Tunariu, Johann S de Bono
Background: Loss of PTEN is a common genomic aberration in castration-resistant prostate cancer (CRPC) and is frequently concurrent with ERG rearrangements, causing resistance to next-generation hormonal treatment (NGHT) including abiraterone. The relationship between PTEN loss and docetaxel sensitivity remains uncertain. Objective: To study the antitumor activity of docetaxel in metastatic CRPC in relation to PTEN and ERG aberrations. Design setting and participants: Single-centre, retrospective analysis of PTEN loss and ERG expression using a previously described immunohistochemistry (IHC) binary classification system...
May 2018: European urology oncology
https://www.readbyqxmd.com/read/29910465/neural-breathing-patterns-in-preterm-newborns-supported-with-non-invasive-neurally-adjusted-ventilatory-assist
#7
Fermín García-Muñoz Rodrigo, Lourdes Urquía Martí, Gloria Galán Henríquez, Sonia Rivero Rodríguez, Alberto Hernández Gómez
OBJECTIVE: To characterize the neural breathing pattern in preterm infants supported with non-invasive neurally adjusted ventilatory assist (NIV-NAVA). STUDY DESIGN: Single-center prospective observational study. The electrical activity of the diaphragm (EAdi) was periodically recorded in 30-second series with the Edi catheter and the Servo-n software (Maquet, Solna, Sweden) in preterm infants supported with NIV-NAVA. The EAdiPeak , EAdiMin , EAdiTonic , EAdiPhasic , neural inspiratory, and expiratory times (nTi and nTe) and the neural respiratory rate (nRR) were calculated...
June 18, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29907675/high-reproducibility-of-an-automated-measurement-of-mobility-for-patients-with-axial-spondyloarthritis
#8
Juan L Garrido-Castro, Rafael Curbelo, Ramón Mazzucchelli, María E Domínguez-González, Cristina Gonzalez-Navas, Bryan J Flores Robles, Pedro Zarco, Juan Mulero, Luis Cea-Calvo, María J Arteaga, Pilar Font-Ugalde, Loreto Carmona, Eduardo Collantes-Estevez
OBJECTIVE: Conventional measures of spinal mobility used in the assessment of patients with axial spondyloarthritis (axSpA), such as the Bath Ankylosing Spondylitis Metrology Index and its components, are subject to interobserver variability. The University of Córdoba Ankylosing Spondylitis Metrology Index (UCOASMI) is a validated composite index based on a motion video-capture system, UCOTrack. Our objective was to assess its reproducibility in clinical practice settings. METHODS: We carried out an observational study of repeated measures in 3 centers...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29903813/first-complete-genome-sequence-of-piscine-orthoreovirus-variant-3-infecting-coho-salmon-oncorhynchus-kisutch-farmed-in-southern-chile
#9
Harry Bohle, Patricio Bustos, Laura Leiva, Horst Grothusen, Esteban Navas, Alvaro Sandoval, Fernando Bustamante, Karen Montecinos, Alvaro Gaete, Marcos Mancilla
We report here the complete genome of an isolate of piscine orthoreovirus variant 3 sequenced from a moribund coho salmon with jaundice that was reared in a seawater farm in southern Chile. The genome consists of 23,627 bp, including 10 segments that range from 1,052 bp (segment S4) to 4,014 bp (segment L1).
June 14, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29903346/infective-endocarditis-in-patients-with-bicuspid-aortic-valve-or-mitral-valve-prolapse
#10
Isabel Zegri-Reiriz, Arístides de Alarcón, Patricia Muñoz, Manuel Martínez Sellés, Victor González-Ramallo, Jose M Miro, Carles Falces, Claudia Gonzalez Rico, Xabier Kortajarena Urkola, José Antonio Lepe, Regino Rodriguez Alvarez, Jose Maria Reguera Iglesias, Enrique Navas, Fernando Dominguez, Pablo Garcia-Pavia
BACKGROUND: There is little information concerning infective endocarditis (IE) in patients with bicuspid aortic valve (BAV) or mitral valve prolapse (MVP). Currently, IE antibiotic prophylaxis (IEAP) is not recommended for these conditions. OBJECTIVES: This study sought to describe the clinical and microbiological features of IE in patients with BAV and MVP and compare them with those of IE patients with and without IEAP indication, to determine the potential benefit of IEAP in these conditions...
June 19, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29902129/serologic-survey-for-selected-viral-and-bacterial-swine-pathogens-in-colombian-collared-peccaries-pecari-tajacu-and-feral-pigs-sus-scrofa
#11
Olga L Montenegro, Nestor Roncancio, Diego Soler-Tovar, Jimena Cortés-Duque, Jorge Contreras-Herrera, Sandra Sabogal, Luz Dary Acevedo, Pedro Enrique Navas-Suárez
In South America, wild populations of peccaries coexist with domestic and feral pigs, with poorly understood consequences. We captured 58 collared peccaries ( Pecari tajacu) and 15 feral pigs ( Sus scrofa) in locations of Colombia where coexistence of these species is known. Blood samples were tested for antibodies against four viral agents, classical swine fever virus (CSFV), Aujeszky's disease virus (ADV), porcine circovirus (PCV-2), and vesicular stomatitis virus (New Jersey and Indiana subtypes) and two bacterial agents, Brucella spp...
June 14, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29898904/should-i-stay-or-should-i-go-copd-and-air-travel
#12
REVIEW
Begum Ergan, Metin Akgun, Angela Maria Grazia Pacilli, Stefano Nava
Chronic obstructive pulmonary disease (COPD) is a challenging respiratory problem throughout the world. Although survival is prolonged with new therapies and better management, the magnitude of the burden resulting from moderate-to-severe disease is increasing. One of the major aims of the disease management is to try to break the vicious cycle of patients being homebound and to promote an active lifestyle. A fundamental component of active daily life is, of course, travelling. Today, the world is getting smaller with the option of travelling by air...
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29890413/emergent-nanotherapies-in-microcrystal-induced-arthritis
#13
REVIEW
Yessica Zamudio-Cuevas, Javier Fernández-Torres, Gabriela Angélica Martínez-Nava, Karina Martínez-Flores, Alberto López-Reyes
The anti-inflammatory and immunomodulatory effects of nanoparticles in several chronic diseases have been extensively researched. The aim of this review is to examine how nanoparticles modulate the inflammatory pathways that characterize the most prevalent forms of microcrystal-induced arthritis, including gout, pseudogout, and BCP-induced arthritis. The nanoparticles of chitosan-coated calcium phosphate, uricase, aceclofenac, and gold have been investigated in crystal-inducedarthritis. The most important results of the studies outlined in this review show that nanoparticles can inhibit the expression and the release of some pro-inflammatory mediators and proteolytic enzymes, and the activity of different transcriptional factors in vitro, as well as decrease the uric acid levels in several studies of in vitro and in vivo models of gout, which show interesting results in terms of decreasing the amount of crystals and tissue damage, respectively...
June 8, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29888277/high-intraspecific-genetic-diversity-of-nocardia-brasiliensis-a-pathogen-responsible-for-cutaneous-nocardiosis-found-in-france-phylogenetic-relationships-by-using-sod-and-hsp65-genes
#14
D Kosova-Maali, E Bergeron, Y Maali, T Durand, J Gonzalez, D Mouniée, H Sandoval Trujillo, P Boiron, M-C Salinas-Carmona, V Rodriguez-Nava
This study aims at genetic characterization and phylogenetic relationships of Nocardia brasiliensis focusing by using housekeeping rrs , hsp65, and sodA genes. N. brasiliensis is the species responsible for 80% of cases of actinomycetoma, one form of cutaneous nocardiosis which occurs mainly in tropical regions reaching immunocompetent patients in which the disease can lead to amputation. We analyze 36 indigenous cases of N. brasiliensis that happened in France. Phylogenetic analysis targeting rrs gene showed no robustness at phylogenetic nodes level...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29884552/feasibility-of-non-invasive-neurally-adjusted-ventilator-assist-after-congenital-diaphragmatic-hernia-repair
#15
Ruchi Amin, Marjorie J Arca
BACKGROUND: The use of neurally adjusted ventilator assist (NAVA) in congenital diaphragmatic hernia (CDH) patients has been historically deemed unwise, since the trigger for breaths is the electromyographic activity of the diaphragmatic muscle. We report on our NAVA experience in CDH patients. METHODS: We performed an IRB-approved retrospective review of newborns from 1/1/2012-1/1/2017 at a Level I Children's Surgery Center undergoing CDH repair. Data obtained included demographics, defect type and repair, respiratory support, and outcomes...
May 19, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29879222/a-retrospective-pathology-study-of-two-neotropical-deer-species-1995-2015-brazil-marsh-deer-blastocerus-dichotomus-and-brown-brocket-deer-mazama-gouazoubira
#16
Pedro Enrique Navas-Suárez, Josué Díaz-Delgado, Eliana Reiko Matushima, Cintia Maria Fávero, Angélica Maria Sánchez Sarmiento, Carlos Sacristán, Ana Carolina Ewbank, Adriana Marques Joppert, Jose Mauricio Barbanti Duarte, Cinthya Dos Santos-Cirqueira, Bruno Cogliati, Leonardo Mesquita, Paulo César Maiorka, José Luiz Catão-Dias
This retrospective study describes the biological and epidemiological aspects, gross and microscopical findings, and most likely causes of death (CD) in two species of Neotropical deer in Brazil. The animals were collected between 1995 and 2015 and represented 75 marsh deer (MD) and 136 brown brocket deer (BBD). Summarized, pneumonia was diagnosed microscopically in 48 MD and 52 BBD; 76 deer suffered trauma, involving dog attack (14 BBD) and vehicle-collision (14 BBD). Pulmonary edema (50 MD; 55 BBD) and congestion (57 MD; 78 BBD) were the most common findings for both species...
2018: PloS One
https://www.readbyqxmd.com/read/29878917/sclerocornea-microphthalmia-aphakia-complex-description-of-two-additional-cases-associated-with-novel-foxe3-mutations-and-review-of-the-literature
#17
Natalia Quiroz-Casian, Oscar F Chacon-Camacho, Tania Barragan-Arevalo, Jessica Nava-Valdez, Esther Lieberman, Acatzin Salgado-Medina, Alejandro Navas, Enrique O Graue-Hernandez, Juan C Zenteno
PURPOSE: To describe 2 sporadic Mexican patients having congenital bilateral, total sclerocornea, aphakia, and microphthalmia associated with novel mutations in the FOXE3 gene. METHODS: Two affected individuals with congenital bilateral, total sclerocornea, aphakia, and microphthalmia underwent detailed examinations including slit-lamp examination, visual acuity, and intraocular pressure measurements. Ocular ultrasonography and ultrasound biomicroscopy were performed...
June 6, 2018: Cornea
https://www.readbyqxmd.com/read/29878169/andrea-nava-md
#18
Bortolo Martini, Gianfranco Buja
No abstract text is available yet for this article.
June 7, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29874848/ethnic-geographic-and-genetic-differences-in-arsenic-metabolism-at-low-arsenic-exposure-a-preliminary-analysis-in-the-multi-ethnic-study-of-atherosclerosis-mesa
#19
Poojitha Balakrishnan, Miranda R Jones, Dhananjay Vaidya, Maria Tellez-Plaza, Wendy S Post, Joel D Kaufman, Suzette J Bielinski, Kent Taylor, Kevin Francesconi, Walter Goessler, Ana Navas-Acien
We investigated the effect of candidate variants in AS3MT (arsenic (III) methyltransferase) with urinary arsenic metabolites and their principal components in a subset of 264 participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Urinary arsenic species, including inorganic arsenic (iAs), monomethylarsonate (MMA), dimethylarsinate (DMA), and arsenobetaine (Ab), were measured using high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICPMS) and corrected for organic sources from seafood consumption by regressing Ab on arsenic species using a validated method...
June 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29872223/first-characterization-of-a-microsporidial-triosephosphate-isomerase-and-the-biochemical-mechanisms-of-its-inactivation-to-propose-a-new-druggable-target
#20
Itzhel García-Torres, Ignacio De la Mora-De la Mora, Gloria Hernández-Alcántara, Dora Molina-Ortiz, Silvia Caballero-Salazar, Alfonso Olivos-García, Gabriela Nava, Gabriel López-Velázquez, Sergio Enríquez-Flores
The microsporidia are a large group of intracellular parasites with a broad range of hosts, including humans. Encephalitozoon intestinalis is the second microsporidia species most frequently associated with gastrointestinal disease in humans, especially immunocompromised or immunosuppressed individuals, including children and the elderly. The prevalence reported worldwide in these groups ranges from 0 to 60%. Currently, albendazole is most commonly used to treat microsporidiosis caused by Encephalitozoon species...
June 5, 2018: Scientific Reports
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